DE60331941D1 - Mutationen in nod2 sind bei patienten mit morbus crohn mit fibrostenosebildung assoziiert - Google Patents
Mutationen in nod2 sind bei patienten mit morbus crohn mit fibrostenosebildung assoziiertInfo
- Publication number
- DE60331941D1 DE60331941D1 DE60331941T DE60331941T DE60331941D1 DE 60331941 D1 DE60331941 D1 DE 60331941D1 DE 60331941 T DE60331941 T DE 60331941T DE 60331941 T DE60331941 T DE 60331941T DE 60331941 D1 DE60331941 D1 DE 60331941D1
- Authority
- DE
- Germany
- Prior art keywords
- disease
- fibrostenosis
- crohn
- fibrostenosing
- nod2
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/172—Haplotypes
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40739102P | 2002-08-30 | 2002-08-30 | |
US10/356,736 US20040053263A1 (en) | 2002-08-30 | 2003-01-30 | Mutations in NOD2 are associated with fibrostenosing disease in patients with Crohn's disease |
PCT/US2003/023926 WO2004020968A2 (en) | 2002-08-30 | 2003-07-30 | Mutations in nod2 are associated with fibrostenosing disease in patients with crohn’s disease |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60331941D1 true DE60331941D1 (de) | 2010-05-12 |
Family
ID=31981139
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60331941T Expired - Lifetime DE60331941D1 (de) | 2002-08-30 | 2003-07-30 | Mutationen in nod2 sind bei patienten mit morbus crohn mit fibrostenosebildung assoziiert |
Country Status (7)
Country | Link |
---|---|
US (2) | US20040053263A1 (de) |
EP (1) | EP1556405B1 (de) |
JP (2) | JP4606877B2 (de) |
AT (1) | ATE462710T1 (de) |
AU (1) | AU2003263834A1 (de) |
DE (1) | DE60331941D1 (de) |
WO (1) | WO2004020968A2 (de) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6828132B2 (en) * | 2001-03-01 | 2004-12-07 | Ultra Biotech Limited | Biological fertilizer compositions comprising garbage |
US20040053263A1 (en) * | 2002-08-30 | 2004-03-18 | Abreu Maria T. | Mutations in NOD2 are associated with fibrostenosing disease in patients with Crohn's disease |
US7662569B2 (en) * | 2003-04-11 | 2010-02-16 | Cedars-Sinai Medical Center | Methods of assessing Crohn's disease patient phenotype by I2 serologic response |
US7592150B2 (en) * | 2003-12-03 | 2009-09-22 | Glycominds, Ltd | Method for diagnosing diseases based on levels of anti-glycan antibodies |
US20060205022A1 (en) * | 2003-12-03 | 2006-09-14 | Nir Dotan | Method for diagnosing and prognosing inflammatory bowel disease and crohn's disease |
EP1692519B1 (de) * | 2003-12-03 | 2010-06-02 | Glycominds Ltd. | Diagnostikverfahren mittels messungen der antiglykan-antikörper-spiegeln |
US7803535B2 (en) * | 2004-03-27 | 2010-09-28 | Hanns-Georg Klein | Polymorphisms in the NOD2/CARD15 gene |
US20080260753A1 (en) * | 2004-04-09 | 2008-10-23 | The Regents Of The University Of California | Mouse Models of Crohn's Disease and a Method to Develop Specific Therapeutics |
EP1819827B1 (de) * | 2004-12-08 | 2010-08-11 | Cedars-Sinai Medical Center | Verfahren zur diagnose von morbus crohn |
US10544459B2 (en) * | 2004-12-08 | 2020-01-28 | Cedars-Sinai Medical Center | Methods of using genetic variants for the diagnosis and treatment of inflammatory bowel disease |
US11268149B2 (en) | 2004-12-08 | 2022-03-08 | Cedars-Sinai Medical Center | Diagnosis and treatment of inflammatory bowel disease |
WO2008101133A2 (en) * | 2007-02-14 | 2008-08-21 | Cedars-Sinai Medical Center | Methods of using genes and genetic variants to predict or diagnose inflammatory bowel disease |
EP2049691A4 (de) * | 2006-07-26 | 2010-06-16 | Genizon Biosciences Inc | Suszeptibilitätsgen für morbus crohn |
CA2671267A1 (en) * | 2006-11-30 | 2008-06-05 | Navigenics Inc. | Genetic analysis systems and methods |
US20080131887A1 (en) | 2006-11-30 | 2008-06-05 | Stephan Dietrich A | Genetic Analysis Systems and Methods |
US20100190162A1 (en) * | 2007-02-26 | 2010-07-29 | Cedars-Sinai Medical Center | Methods of using single nucleotide polymorphisms in the tl1a gene to predict or diagnose inflammatory bowel disease |
WO2008137762A2 (en) * | 2007-05-04 | 2008-11-13 | Cedars-Sinai Medical Center | Methods of diagnosis and treatment of crohn's disease |
US20100015156A1 (en) * | 2007-03-06 | 2010-01-21 | Cedars-Sinai Medical Center | Diagnosis of inflammatory bowel disease in children |
US8486640B2 (en) | 2007-03-21 | 2013-07-16 | Cedars-Sinai Medical Center | Ileal pouch-anal anastomosis (IPAA) factors in the treatment of inflammatory bowel disease |
WO2008134569A2 (en) * | 2007-04-26 | 2008-11-06 | Cedars-Sinai Medical Center | Diagnosis and treatment of inflammatory bowel disease in the puerto rican population |
EP2220507B1 (de) * | 2007-11-30 | 2012-09-12 | Glycominds Ltd. | Zusammensetzung und verfahren zur vorhersage eines komplizierten krankheitsverlaufs und von operationen bei morbus crohn |
WO2009143278A2 (en) * | 2008-05-20 | 2009-11-26 | Cedars-Sinai Medical Center | Methods of diagnosing and characterizing cannabinoid signaling in crohn's disease |
US20110177969A1 (en) * | 2008-10-01 | 2011-07-21 | Cedars-Sinai Medical Center | The role of il17rd and the il23-1l17 pathway in crohn's disease |
US20110189685A1 (en) * | 2008-10-22 | 2011-08-04 | Cedars-Sinai Medical Center | Methods of using jak3 genetic variants to diagnose and predict crohn's disease |
WO2010062960A2 (en) | 2008-11-26 | 2010-06-03 | Cedars-Sinai Medical Center | METHODS OF DETERMINING RESPONSIVENESS TO ANTI-TNFα THERAPY IN INFLAMMATORY BOWEL DISEASE |
US9580752B2 (en) | 2008-12-24 | 2017-02-28 | Cedars-Sinai Medical Center | Methods of predicting medically refractive ulcerative colitis (MR-UC) requiring colectomy |
WO2010120814A1 (en) | 2009-04-14 | 2010-10-21 | Prometheus Laboratories Inc. | Inflammatory bowel disease prognostics |
WO2011060098A1 (en) | 2009-11-10 | 2011-05-19 | Prometheus Laboratories Inc. | Methods for predicting post-surgery risk associated with ileal pouch-anal anastomosis |
WO2011088306A1 (en) * | 2010-01-15 | 2011-07-21 | Cedars-Sinai Medical Center | Methods of using genetic variants to diagnose crohn's disease |
SG189391A1 (en) | 2010-10-18 | 2013-05-31 | Nestec Sa | Methods for determining anti-drug antibody isotypes |
DK2676137T3 (en) | 2011-02-17 | 2015-01-19 | Nestec Sa | TESTS TO DETECT AUTO ANTIBODIES FOR ANTI-TNF PHARMACEUTICALS |
JP2014515599A (ja) * | 2011-03-25 | 2014-07-03 | セダーズ−シナイ メディカル センター | 炎症性腸疾患における腸の肉芽腫および低骨密度を診断および処置する方法 |
RU2013154566A (ru) | 2011-05-10 | 2015-06-20 | Нестек С.А. | Способы анализа профиля активности болезни с целью проведения индивидуального лечения |
CA2852954A1 (en) | 2011-10-21 | 2013-04-25 | Nestec S.A. | Methods for improving inflammatory bowel disease diagnosis |
AU2014241162A1 (en) | 2013-03-27 | 2015-10-22 | Cedars-Sinai Medical Center | Mitigation and reversal of fibrosis and inflammation by inhibition of TL1A function and related signaling pathways |
CN115261411A (zh) | 2013-04-04 | 2022-11-01 | 哈佛学院校长同事会 | 利用CRISPR/Cas系统的基因组编辑的治疗性用途 |
WO2015010108A1 (en) | 2013-07-19 | 2015-01-22 | Cedars-Sinai Medical Center | Signature of tl1a (tnfsf15) signaling pathway |
IL254734B2 (en) | 2015-03-27 | 2023-09-01 | Harvard College | Modified t cells and methods for their preparation and use |
CN109462996A (zh) | 2016-03-17 | 2019-03-12 | 西达-赛奈医疗中心 | 通过rnaset2诊断炎性肠病的方法 |
US11913015B2 (en) | 2017-04-17 | 2024-02-27 | University Of Maryland, College Park | Embryonic cell cultures and methods of using the same |
WO2020139748A1 (en) * | 2018-12-28 | 2020-07-02 | Cedars-Sinai Medical Center | Methods of treating inflammatory bowel diseases that target ripk2 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3157053B2 (ja) * | 1992-09-16 | 2001-04-16 | ティーディーケイ株式会社 | Dna作用物質の結合様式特定方法 |
US5830675A (en) * | 1993-03-10 | 1998-11-03 | Cedars-Sinai Medical Center | Methods for selectively detecting perinuclear anti-neutrophil cytoplasmic antibody of ulcerative colitis, primary sclerosing cholangitis, or type 1 autoimmune hepatitis |
ATE193601T1 (de) * | 1993-03-10 | 2000-06-15 | Cedars Sinai Medical Center | Verfahren zum selektiven nachweis von perinuklearen anti-neutrophilen cytoplasmischen antikörpern bei ulzerativen kolitis oder primärer sclerotischer cholangitis |
US5691151A (en) * | 1994-10-07 | 1997-11-25 | Regents Of University Of California | Methods of screening for ulcerative colitis and crohn's disease by detecting VH3-15 autoantibody and panca |
US5874233A (en) * | 1996-04-12 | 1999-02-23 | Cedars-Sinai Medical Center | Methods of diagnosing a clinical subtype of Crohn's disease with features of ulcerative colitis |
US5916748A (en) * | 1996-04-12 | 1999-06-29 | Cedars-Sinai Medical Center | Method of diagnosing a clinical subtype of crohn's disease with features of ulcerative colitis |
US6074835A (en) * | 1996-04-12 | 2000-06-13 | Regents Of The Univ. Of California | Diagnosis, prevention and treatment of ulcerative colitis, and clinical subtypes thereof, using histone H1 |
WO1997038642A1 (en) * | 1996-04-12 | 1997-10-23 | Cedars-Sinai Medical Center | Methods of determining the risk of pouchitis development |
US5968741A (en) * | 1997-04-11 | 1999-10-19 | Cedars-Sinai Medical Center | Methods of diagnosing a medically resistant clinical subtype of ulcerative colitis |
US6514700B1 (en) * | 1999-04-30 | 2003-02-04 | Aclara Biosciences, Inc. | Nucleic acid detection using degradation of a tagged sequence |
JP2001269196A (ja) * | 2000-03-24 | 2001-10-02 | Hamamatsu Photonics Kk | 被検体核酸の定量方法、および被検体核酸の分子数の計数方法 |
US7138237B1 (en) * | 2000-05-19 | 2006-11-21 | Cedars-Sinai Medical Center | Diagnosis, prevention and treatment of Crohn's disease using the OmpC antigen |
US20030092019A1 (en) * | 2001-01-09 | 2003-05-15 | Millennium Pharmaceuticals, Inc. | Methods and compositions for diagnosing and treating neuropsychiatric disorders such as schizophrenia |
US20040053263A1 (en) | 2002-08-30 | 2004-03-18 | Abreu Maria T. | Mutations in NOD2 are associated with fibrostenosing disease in patients with Crohn's disease |
-
2003
- 2003-01-30 US US10/356,736 patent/US20040053263A1/en not_active Abandoned
- 2003-07-30 WO PCT/US2003/023926 patent/WO2004020968A2/en active Application Filing
- 2003-07-30 EP EP03791618A patent/EP1556405B1/de not_active Expired - Lifetime
- 2003-07-30 DE DE60331941T patent/DE60331941D1/de not_active Expired - Lifetime
- 2003-07-30 US US10/526,256 patent/US7790370B2/en active Active
- 2003-07-30 AT AT03791618T patent/ATE462710T1/de not_active IP Right Cessation
- 2003-07-30 JP JP2004532837A patent/JP4606877B2/ja not_active Expired - Fee Related
- 2003-07-30 AU AU2003263834A patent/AU2003263834A1/en not_active Abandoned
-
2010
- 2010-08-02 JP JP2010174021A patent/JP2011015686A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
EP1556405B1 (de) | 2010-03-31 |
AU2003263834A8 (en) | 2004-03-19 |
ATE462710T1 (de) | 2010-04-15 |
US20070072180A1 (en) | 2007-03-29 |
JP4606877B2 (ja) | 2011-01-05 |
WO2004020968A2 (en) | 2004-03-11 |
EP1556405A4 (de) | 2007-01-10 |
WO2004020968A3 (en) | 2004-08-26 |
JP2011015686A (ja) | 2011-01-27 |
US7790370B2 (en) | 2010-09-07 |
AU2003263834A1 (en) | 2004-03-19 |
JP2006500016A (ja) | 2006-01-05 |
EP1556405A2 (de) | 2005-07-27 |
US20040053263A1 (en) | 2004-03-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |