JP2006262768A - Health food and skin inflammation soothing agent - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide health food enhancing natural healing power inherent in human beings so as to be useful to prevention of and recovery from various kinds of disease, anti-aging in osteoporosis, dementia and the like, upgrade of internal organs such as the liver or the kidney, prevention of allergic symptoms such as atopy, chronic rhinitis and phthisis, and internal reform; and to provide a skin inflammation soothing agent. <P>SOLUTION: The health food and the skin inflammation soothing agent are each obtained by formulation of material produced by subjecting coconut water to fermentation with lactobacillus as an active ingredient. The "coconut water" is used as raw material so as to be relatively easy to obtain low-calorie health food. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention enhances the natural healing power inherent in humans, prevents and recovers various diseases, prevents aging such as osteoporosis and dementia, improves the function of internal organs such as the liver and kidneys, atopy, chronic rhinitis, asthma, etc. The present invention relates to a health food and a dermatitis alleviating agent that are useful for preventing allergy symptoms and improving constitution.

  Lactic acid bacteria fermented beverages and lactic acid bacteria fermented foods typified by yogurt are recognized as having an intestinal effect, as well as having allergy suppression and anticancer effects, and are becoming popular as inexpensive and easy-to-use health foods. ing.

  The reason why such attention has been gathered for such lactic acid bacteria fermented beverages and lactic acid bacteria fermented foods is the immediate effect of lactic acid bacteria fermented beverages and lactic acid bacteria fermented foods, that is, lactic acid bacteria fermented beverages and lactic acid bacteria fermented foods On the day or the day after taking the food, the effect of improving gastrointestinal tone or relieving constipation appears clearly, and asthma can be achieved by taking lactic acid bacteria fermented beverages or lactic acid bacteria fermented foods. There are reports that seizures have been alleviated.

  Therefore, recently, various lactic acid bacteria fermented beverages and lactic acid bacteria fermented foods typified by the yogurt have been developed (for example, Patent Documents 1 to 3).

JP 2000-069935 A JP2003-038122 JP2004-154086

  However, in the lactic acid bacteria fermented beverages and lactic acid bacteria fermented foods disclosed in these patent documents, since milk is mainly used as a raw material, during the fermentation and treatment with lactic acid bacteria, the fat content and protein in the milk Are prone to spoilage and breeding of Escherichia coli. Therefore, considerable care must be taken to preserve and maintain the freshness of milk as a raw material and to sterilize and disinfect equipment in the manufacturing plant.

  In addition, since milk contains a lot of fat, it has a relatively high calorie. Therefore, health foods made from milk with such a high calorie generally tend to have a high calorie, and in recent years the calorie has increased. There is also a problem that calories are inevitably exceeded if a large amount is continuously consumed with a meal said to be present.

  Thus, as a result of repeated studies by the inventor in order to solve the above problems, the health food of the present invention is characterized in that coconut water is fermented and treated with lactic acid bacteria as an active ingredient. It has come.

  That is, the present inventor noted that coconut water contains a relatively large amount of starch, but the protein and fat content is about 0.1% or less, and the coconut water is fermented and treated with lactic acid bacteria. If you obtain the knowledge that low-calorie health food can be obtained relatively easily, ferment and treat such coconut water with lactic acid bacteria, and take the health food with this as an active ingredient orally Thus, it was found that an immediate effect on intestinal regulation, allergy suppression and anticancer action can be obtained without worrying about calorie over.

  At the same time, coconut water contains abundant minerals such as sodium, calcium, magnesium, phosphorus, and iron, so such coconut water is fermented and processed with lactic acid bacteria, and health food containing this as an active ingredient is taken orally. In addition, they also found that if taken into the body, various diseases caused by mineral deficiencies can be prevented and ameliorated.

  In addition, as described above, protein and fat contained in coconut water are about 0.1% or less, so that it is difficult for spoilage and E. coli to occur during fermentation and treatment with lactic acid bacteria, and coconut water as a raw material is used. It was also found that handling such as preservation and maintenance of freshness is relatively simple.

  Furthermore, most of the current use of coconut palms is that in Sri Lanka, only coconut milk and palm oil are extracted from the harvested coconut endosperm, and only a small amount of coconut palm water is consumed locally. Most of the waste is almost discarded, and the amount of waste reaches 400,000 to 500,000 tons per day. By using coconut water, which is a waste of coconut palm, a large amount of health food is provided at a low price. I got the knowledge that I can do it.

  The present invention has been completed on the basis of the above findings, and enhances the natural healing power inherent in humans, prevention and recovery of various diseases, prevention of aging such as osteoporosis and dementia, and visceral organs such as liver and kidney. The purpose of the present invention is to provide a health food and a dermatitis alleviating agent that are useful for improving the function and preventing or improving allergies such as atopy, chronic rhinitis and asthma.

  In order to achieve this object, the health food according to the present invention is characterized in that coconut water is fermented and treated with lactic acid bacteria as an active ingredient.

  The reason for using such “coconut water” as a raw material for the health food of the present invention is that, as described above, coconut water contains a relatively large amount of starch, but the fat content is 0.1% or less. This is because, if such low-fat coconut water is used as a raw material, a low-calorie health food can be obtained relatively easily.

  In addition, coconut water contains abundant mineral components such as sodium, calcium, magnesium, phosphorus, and iron. Fermentation and treatment of such coconut water with lactic acid bacteria and oral health food containing this as an active ingredient If taken into the body, it is possible to obtain an immediate effect of intestinal regulation, allergy suppression and anticancer action without worrying about over calories, as well as prevention of various diseases caused by lack of minerals. This is because improvement can also be made possible.

  Furthermore, if low-fat coconut water is used as a raw material, it is difficult for spoilage and E. coli to occur during fermentation and treatment with lactic acid bacteria, and handling such as preservation and freshness maintenance of coconut water as a raw material can be made relatively simple. Because.

  In addition, most of the current use of coconut palm is just squeezed coconut milk and palm oil from the harvested coconut endosperm, and the coconut water is almost discarded, making it most effective use. Since the amount of waste reaches 400,000 to 500,000 tons per day, the use of coconut palm water, which is a waste of coconut palm, can provide a large amount of health food at low cost. Because it can.

  The health food according to the present invention is characterized in that the above coconut water is fermented and treated with lactic acid bacteria, and this is blended as an active ingredient. The means for fermenting and treating coconut water with lactic acid bacteria is inoculated with lactic acid bacteria. If it is fermentation by this, it will not restrict | limit in particular, What is necessary is just to determine and adjust suitably the fermentation conditions, fermentation temperature, pH of coconut water, fermentation time, etc. of each lactic acid bacteria.

  At this time, various nutrients including starch, acid for adjusting pH, alkali and the like may be added as appropriate, and the fermentation may be mixed fermentation or continuous fermentation.

  And after fermentation, it may filter and may refine | purify processes, such as deodorizing and decoloring, using a sterilization process, pH adjustment, an ion exchange resin, an activated carbon column, a dialysis membrane, etc. if desired.

  Here, the term “lactic acid bacteria” used in the present invention refers to Lactobacilliaceae, Lactobacillus, Actinomycete Bifidus, Sporeococcus, Spore Lactobacillus, Streptococcus pediococcus, Enterococcus faecalis , Lactobacillus genus, Leuconostoc genus, etc., and the “Lactobacilliaceae Lactobacillus genus fungi” include, for example, Lactobacillusae, Lactobacillus fungi: Lactobacillus acidophilus, Lactobacillus, Lactobacillus, Lactobacillus bulgaricus, Lactobacillus casei, Lactobacillus delbruckii, Lactobacillus fermenti, Lactobac llus helveticus, Lactobacillus jugurti, Lactobacillus lactis, and the like can be given Lactobacillus plantarum.

  In addition, said as "actinomycetes Kinka Bifidasu genus fungus" is, fungi actinomycetes family (Actinomycetaceae), Bifidasu bacteria belonging to the genus (Bifidobacterium): Bifidobacterium adolescentis, Bifidobacterium bifidum, Bifidobacterium breve, Bifidobacterium infantis, Bifidobacterium lactentis, Bifidobacterium liberorum, Bifidobacterium longum, Bifidobacterium parvularum, Bifidobacterium pseudolongum, Bifidobacterium thermophilum, etc. It is than can be mentioned, it said as "spore bacillus Department of spore Lactobacillus fungus" is, fungal spore bacillus family, spore Lactobacillus (Sporolactobacillus): such as Sporolactobacillus inulinus can be mentioned.

  Further, as the above-mentioned “Reptococcus pediococcus fungi”, Streptococcus family, Pediococcus fungus, Enterococcus faecalis Lactococcus: Pedicoccus faecalis Pediococcus halophilus, Pediococcus pentoaceaceus, etc. can be mentioned, and as for the above-mentioned "Streptococcus family Streptococcus", Streptococcus family, Streptococcus genus Streptococcus: coccus diacetilactis, Streptococcus faecalis, Streptococcus faecium, Streptococcus lactis, Streptococcus lactis sub-sp. Examples thereof include diacetylactis, Streptococcus thermophilus, Streptococcus uberis, and the like.

  In addition, the “Reptococcus family Leuconostoc genus fungi” includes Streptococcus family, Leuconostoc genus fungi: Leuconostoc citrovorum, Leuconostoc cremoris, Leuconostoc cremoris, Leuconostoc cremori .

  In addition, in this invention, the genus species of the said lactic acid bacteria can also be used, and the thing of these arbitrary hybrids can also be used.

  The health food of the present invention is obtained by fermenting and treating such coconut water with lactic acid bacteria as an active ingredient, and this may be used as a final product as it is. Extraction and moisture may be skipped to concentrate the contained components.

  In the health food according to the present invention, it is also beneficial to add coconut sap to coconut water, ferment and treat with lactic acid bacteria contained in the sap of the coconut palm, and blend this as an active ingredient.

  At this time, in order to maintain the quality of the health food of the present invention, it is preferable to carry out under working conditions and low temperature conditions that do not touch the outside air (oxygen) as much as possible. For example, under nitrogen atmosphere or low temperature conditions, freeze drying, etc. It is preferable to dry using a means under conditions that do not deteriorate the activity of the active ingredient.

  The degree of concentration may be adjusted as appropriate according to the form of the subsequent health food, and may be in the state of a concentrated solution from which a certain amount of moisture has been removed, or may be completely powdered by removing moisture. It ’s good.

  And since the health food in the present invention is obtained by fermenting and treating coconut water with lactic acid bacteria, it is rich in various mineral components as well as lactic acid bacteria metabolites that are said to enhance the natural healing power inherent in humans. Yes, it is not limited to the one that only fermented and treated coconut water with lactic acid bacteria, but sugar, alcohol, saturated fatty acid, unsaturated fatty acid, vitamin, trace element, amino acid, neurotransmitter, stimulant, Additives such as compounds that stimulate blood flow or plant extracts may be added as appropriate.

Specific examples of these additives include DHA (docosahexaenoic acid) that promotes the secretion of acetylcholine, vitamin B ₁₂ that transmits instructions from nerve cells to others, vitamin E that reduces active oxygen, and the synthesis of acetylcholine. Vitamin C that promotes the absorption of iron, calcium pantentate that promotes the production of acetylcholine, lactic acid bacteria that regulate the amount of cholesterol in the blood, sodium ferrous citrate and ginkgo biloba extract that promote the increase in cerebral blood flow, blood flow Examples include garlic powder to be improved, and other mineral components such as zinc and oyster shell powder.

  Other active ingredients include active substances from Rhodiola, Ginseng, Ginseng, Suma, Chamomile, Weeping Willow, Mayo, Passiflora, Birch, Hypericum, valerian, Garlic, Reishitake and / or Garana, Phosphatidylethanolamine, Thosphatidino , Taurine, serine, carnitine, phenylalanine, melatonin, tyrosine, theanine, ethanol, creatine citric acid, creatine pyruvic acid, barbituric acid (derivative), and mixtures thereof can be selected and blended as appropriate.

  The health food in the present invention is finally formed, for example, as a powder, tablet, drink, capsule, etc., and the product form is not particularly limited, but is exposed to the air. When stored for a long period of time, there is a risk of oxidation / degeneration, so that a capsule-type health food enclosed in a capsule is particularly preferable.

  As the capsule base for filling this health food, a known capsule base that is currently used generally can be suitably used. For example, it is sealed in a hard capsule made of gelatin, or glycerin is added to gelatin. There is a method in which a concentrated component of coconut water is placed between two gelatin bases made soft by adding and placed on a mold and pressed into a sphere or ellipsoid by hot pressing.

In the present invention, an appropriate formulation aid may be appropriately blended depending on the form of each product. Examples of the formulation aid include carbohydrates such as methylcellulose, SiO ₂ , stearate. And solubilizers, dyes and flavors, preservatives and separating agents, and lubricants.

  By the way, the health food of the present invention is supposed to be taken orally. However, the health food of the present invention is used as it is or dissolved in various solvents such as water, ethanol, ethylene glycol and the like on the skin surface. It can spread and be absorbed through the skin, and maintains good moisture retention on the skin surface, so it is particularly effective against allergic dermatitis typified by atopic dermatitis. It becomes a good dermatitis alleviator.

  The present invention is a novel health food having the above-described configuration, characterized in that coconut water fermented and treated with lactic acid bacteria is blended as an active ingredient.

  That is, since the health food of the present invention uses “coconut water” as a raw material, a low-calorie health food can be obtained relatively easily.

  Moreover, since coconut water contains abundant mineral components such as sodium, calcium, magnesium, phosphorus and iron, the coconut water is fermented and treated with lactic acid bacteria, and the health of the present invention using this as an active ingredient By taking foods into the body orally, you can obtain an immediate effect of intestinal regulation, allergy suppression and anticancer action without worrying about over calories, and various diseases caused by mineral deficiencies Prevention and improvement can also be made possible.

  Furthermore, because coconut water is low in fat, it is difficult for spoilage and E. coli to occur during fermentation and treatment with lactic acid bacteria, and handling of coconut water as a raw material and maintenance of freshness is relatively simple. is there.

  In addition, most of the current use of coconut palm is just squeezed coconut milk and palm oil from the harvested coconut endosperm, and the coconut water is almost discarded, making it most effective use. Since the amount of waste reaches 400,000 to 500,000 tons per day, a large amount of health food can be manufactured at low cost by using coconut water, which is a waste of coconut. It can be done.

  On the other hand, the dermatitis alleviating agent of the present invention is characterized in that the health food of the present invention is used as it is or after being dissolved in various solvents such as water, ethanol, ethylene glycol and the like, spread on the skin surface. In particular, since various active ingredients contained in the health food of the present invention can be ingested percutaneously and maintain good moisture retention on the skin surface, it is particularly represented by atopic dermatitis. It becomes an effective dermatitis alleviating agent against allergic dermatitis.

  Examples of the present invention will be specifically described below, but the present invention is not limited to these examples.

  Table 1 shows the components contained in 100 g of coconut water used in this example.

  From the values in Table 1, it can be confirmed that coconut water contains a very large amount of carbohydrates (starch), while having very little protein and fat.

  It can also be confirmed that the coconut water contains the mineral components in a well-balanced manner.

  And the health food of this invention was obtained by adding lactic acid bacteria (Lactobacillus casei (0.5 kg)) with respect to this coconut water (1 kg), and fermenting overnight at a fixed temperature of about 37 degreeC.

  Twenty mice transplanted with ascites cancer were divided into two groups of 10 each, group A and group B. Group A was given a sufficient amount of food supplemented with 30% by weight of the health food of the present invention every day, Group B was given a normal diet with nothing added daily in the same amount as Group A, and each group was comparatively tested.

  As a result, the average survival time of the mice in Group B was 13.5 days, whereas the average survival time of the mice in Group A was 21.0 days, and the survival rate of Group A was 155.5. Calculated as a percentage.

  That is, from this comparative test, it was confirmed that the anti-cancer action expressed by the health food of the present invention was confirmed, and the health food of the present invention delayed the progression of cancer and significantly increased the survival rate.

  50 panelists suffering from atopic dermatitis were divided into two groups of 25 people each, group A and group B, and the dermatitis mitigation effect when the health food of the present invention was spread on the skin was determined.

  In addition, when the high-frequency electrical conductivity (skin surface conductance) of all 50 skins was measured as an index of the keratin moisture content of the paneler before the test, the average skin surface conductance of the 50 panelists was 4.5. It was confirmed that the skin surface was a so-called rough skin condition in which partial exfoliation of the keratin was observed as [μm (mho)].

  The health food of the present invention (dermatitis alleviating agent) was instructed to use 25 people of Group A after washing each morning and after taking a bath before going to bed. The effect was judged.

  As a result, there were 16 people who recognized that itching and inflammation of the face were alleviated by repeated use of the health food (dermatitis alleviation agent) of the present invention, and those that were recognized that itching and inflammation of the face were alleviated to some extent. There were five, and the remaining three alleged that facial itching and inflammation were alleviated somewhat.

  On the other hand, 25 people in Group B were instructed to use commercially available lotion after washing each morning and taking a bath before going to bed, and when the dermatitis mitigating effect on the face was determined on the 30th day, There was no change in itch or inflammation.

  In addition, after the test, the skin surface conductance of 25 persons in Group A and 25 persons in Group B was measured, and the average value of the skin surface conductance of 25 panelists in Group A was 6.5 [μm (mho)]. It was confirmed that the skin surface properties were improved to a beautiful skin condition with clear skin grooves and cuticles, while the average skin surface conductance of 25 panelists in Group B The value remained at 4.5 [μm (mho)], and no improvement in skin surface properties was confirmed.

  From the above results, the dermatitis alleviating agent that spreads and uses the health food of the present invention on the skin has an excellent mitigating action against dermatitis such as atopic dermatitis, and further, the skin keratin moisture content It has been found that it exhibits excellent moisturizing power that normalizes the skin and restores the homeostatic function of the skin.

Claims (7)

A health food comprising coconut water fermented and treated with lactic acid bacteria as an active ingredient. The health food according to claim 1, wherein the lactic acid bacteria are lactic acid bacteria contained in sap of coconut palm. As an additive, at least one selected from sugar, alcohol, saturated fatty acid, unsaturated fatty acid, vitamin, trace element, amino acid, neurotransmitter, stimulant, blood flow stimulating compound or plant extract is blended. The health food according to claim 1 or 2. As active ingredients, active substances from Rhodiola, ginseng, ginseng, suma, chamomile, weeping willow, maize, passiflora, birch, hypericum, valerian, garlic, litchitake and / or guarana, phosphatidylethanolamine, phosphatidylinositol, And at least one selected from carnitine, phenylalanine, melatonin, tyrosine, theanine, ethanol, creatine citric acid, creatine pyruvic acid, barbituric acid (derivative), and mixtures thereof. The health food according to any one of the above. The health food according to any one of claims 1 to 4, which is formed into a powder, tablet, drink or capsule form. As a formulation aid, at least one selected from carbohydrates such as methylcellulose, SiO ₂ , stearates, solubilizers, dyes, flavoring agents, preservatives, separating agents or lubricants is blended. The health food according to any one of claims 1 to 5. A dermatitis alleviating agent characterized by using the health food according to any one of claims 1 to 6 spread on the skin surface.