JP2006076909A - Method for producing neem extract and low irritating cosmetic composition containing the same - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a method of obtaining a neem extract which is safe without skin sensitization and photosensitization and has low skin irritation without adversely affecting the efficacy of neem as such, and a low irritating cosmetic composition which contains the obtained neem extract and excels in beautification effect. <P>SOLUTION: The method of obtaining the neem extract which is safe and has low skin irritation comprises subjecting a steam distillation residue of neem to solvent extraction. The low irritating cosmetic composition contains this neem extract. By this method, a high safety neem extract free of skin irritation such as skin sensitization and photosensitization can be obtained, and it does not damage the efficacy of melanism inhibition and histamine liberation inhibition which the neem extract obtained by the conventional method possesses. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to a method for producing a neem extract that is safe and has low skin irritation, and a hypoallergenic cosmetic composition containing the neem extract obtained thereby.

  Many reports have been made as methods for preventing or improving dark spots due to skin spots (spots), sparrow eggs (sobacus) and pigmentation, and arbutin, kojic acid, glutathione and the like are known. In addition, histamine release inhibitors and hyaluronidase inhibitors have been reported as methods for preventing skin inflammation and allergies such as atopic dermatitis and rough skin, and steroids and glycyrrhizin are known. None of the drugs satisfied all of the safety, stability, and efficacy.

On the other hand, neem extract is highly effective as a composition for preventing touch, an antioxidant, and an anti-inflammatory / anti-itch agent, and many reports have been made in the past (see Patent Documents 1-3). In these production methods, medicinal components are extracted from neem with an organic solvent such as methanol and ethanol, water, a mixture thereof, and the like. In addition, a method of extracting with an organic solvent having a dielectric constant of 10 or less and extracting from the extraction residue using a hydrophilic solvent having a dielectric constant of 15 to 35 has been disclosed. Antibacterial effects have been found (see Patent Documents 4 to 7, etc.).
JP-A-60-54312 JP 06-100412 JP 06-199675 JP 57-38718 JP-A-57-38719 JP-A-57-38720 JP 57-48922

  However, when extracted by a conventional method, irritation such as skin sensitization and photosensitization is confirmed. Accordingly, an object of the present invention is to provide a method for obtaining a safe and low skin irritation neem extract having no skin sensitization or photosensitization without impairing the effectiveness of the neem itself, and the obtained neem extract. It is an object of the present invention to provide a hypoallergenic cosmetic composition having excellent cosmetic effects.

  Under these circumstances, the present inventors have found a method for obtaining a neem extract that is safe and low in skin irritation by solvent extraction from neem steam distillation residue, and have completed the invention.

  The present invention also provides a hypoallergenic cosmetic composition comprising a neem extract obtained by the above production method according to the present invention.

  According to the production method of the present invention, a highly safe neem extract that does not cause skin irritation such as skin sensitization and photosensitization can be obtained, and the neem extract obtained by a conventional production method has Neither the melanin production inhibitory effect nor the histamine release inhibitory effect was impaired.

  Moreover, it became possible to provide a hypoallergenic cosmetic composition by applying the neem extract obtained by the production method of the present invention. In addition, it can be applied to all forms of preparations such as cosmetic compositions, pharmaceutical compositions, quasi-drug compositions, and foods and drinks, skin darkening caused by spots, freckles, dullness, or exposure to ultraviolet rays, etc. In addition to whitening effects such as effective suppression and improvement of skin pigmentation of skin, prevention and improvement of various diseases and functional deterioration accompanied by inflammation, various symptoms associated with physiological aging of skin and photoaging, such as Can be expected to prevent and improve wrinkles and sagging.

  The neem used in the present invention is a flower of the Sendai family: Neem Melia azadirachta L. (= Azadirachta indica Juss.) (Also known as Neem, Margosa), flower, ear, pericarp, fruit, leaf, branch, bark, Rhizome, root bark, root, seed, aerial part or whole plant is used, but leaves are preferably used. In addition, Azadirachta excelsa of the same genus can be used. Neem is an evergreen tree with feathery compound leaves, distributed in a dry forest from the Indian Deccan Plateau to Myanmar, and is widely cultivated in India, Malaysia and Africa. In India, it is used for skin diseases and can also be used to make soap. The bark has become medicinal and is made into fever and tonic. The leaves are also used for medicinal purposes and are supposed to prevent insect damage if placed between books.

  The steam distillation method has been known for a long time as a means for obtaining essential oil from plants, for example, from the following literature (Location of reference: Masao Fujimaki et al. “Encyclopedia of Fragrance” p366.1, August 27, 1980 Published by Asakura Shoten, Tokuhei Kametaka “Theoretical and Applied Organic Chemistry / 21st Edition” p13. Published April 5, 1951 (Maruzen Publishing). The steam distillation apparatus and the principle are also described in the above-mentioned literature. Steam distillation is not particularly limited, and may be employed for collecting essential oils. The obtained residue can be used as it is or after drying.

  The extraction solvent used in the present invention may be selected in consideration of the intended purpose and type of the product to be provided, or the processing to be performed later. Usually, water, methanol, ethanol, propyl alcohol, isopropyl alcohol, Lower alcohol such as butanol and isobutanol or hydrous lower alcohol, propylene glycol, 1,3-butylene glycol, 1,2-butylene glycol, 1,4-butylene glycol, 1,5-pentanediol, 1,2-pentanediol 1,3-pentanediol, 1,4-pentanediol, 1,3,5-pentanetriol, glycerin, polyhydric alcohols such as polyethylene glycol (molecular weight 100 to 100,000) or water-containing polyhydric alcohols, acetone, ethyl acetate , Diethyl ether, dimethyl ether, ethyl methyl ether, dioxane, acetonitrile Various organic solvents such as ril, xylene, benzene, chloroform, carbon tetrachloride, phenol, toluene, etc., acids (hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, formic acid, acetic acid, etc.) and alkalis (sodium hydroxide) prepared as appropriate , Potassium hydroxide, calcium hydroxide, ammonia, etc.) is preferably used. However, if it is not preferable to use a solvent depending on the application, use water alone, or use a highly volatile solvent that can be easily removed after extraction, and dissolve in water after removing the solvent. Such a method is also possible. Moreover, you may perform extraction extraction suitably.

  Regarding the extraction method, the temperature of the solvent, the weight ratio of the solvent to the raw material, or the extraction time can be arbitrarily set for various raw materials and the solvent used. The temperature of the solvent can be arbitrarily set in the range of −4 ° C. to 100 ° C., but is preferably around 10 to 40 ° C. from the viewpoint of the stability of the components contained in the raw material. Also, the weight ratio of the solvent to the raw material can be arbitrarily set within a range of, for example, raw material: solvent of 4: 1 to 1: 100, and a weight ratio of 1: 1 to 1:20 is particularly preferable.

  In the present invention, after solvent extraction, it is possible to further carry out a purification operation as appropriate. Examples of the purification operation include acid (hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, organic acid, etc.) or alkali (sodium hydroxide, calcium hydroxide, Decomposition by addition of ammonia, etc., fermentation or metabolic conversion by microorganisms, component adsorption by ion exchange resin, activated carbon, diatomaceous earth, etc., various separation modes (ion exchange, hydrophilic adsorption, hydrophobic adsorption, size exclusion, ligand) Fractionation using chromatography with exchange, affinity, etc., filtration using filter paper or membrane filter, ultrafiltration membrane, etc., pressurization or decompression, heating or cooling, drying, pH adjustment, deodorization, decolorization, long For example, stationary storage of time can be exemplified, and it is possible to arbitrarily select and combine these.

  The form of the neem extract used in the present invention may be any form such as liquid, solid, powder, paste, gel, etc., and an optimum shape is arbitrarily selected for constituting the final product. be able to.

  The cosmetic composition according to the present invention includes 1) topical or systemic skin cleanser or skin cosmetics, 2) medicinal and / or cosmetic preparations applied to the scalp and hair, and 3) bathing in bath water. 4) Deodorant / deodorant for human body, 5) Sheet for skin application, cosmetic sheet, cosmetic cotton, hygiene products, sanitary cotton, wet tissue, etc. , Capsules, powders, granules, solids, solutions, gels, bubbles, emulsions, sheets, mists, sprays, etc.

  Specifically, topical cosmetics such as topical medicinal preparations, lotions, emulsions, creams, ointments, lotions, oils, packs, shampoos, rinses, treatments, etc., hair creams, hair sprays, hair Hair tonics such as tonics, hair gels, hair lotions, hair oils, hair essences, hair waters, hair waxes, hair foams, hair growth and hair nourishing agents, one-part hair dyes, two-part hair dyes, hair colors, etc. Permanent agents such as permanent wave agents and hair straighteners, hair cosmetics such as wave retention agents, hair solvents such as hair removal inhibitors and hair removal agents, foundations, white powder, candy, lipstick, blusher, eye shadow, eyeliner Oral compositions such as makeup cosmetics such as mascara, eyebrows and eyelashes, finishing cosmetics such as beauty nails, perfumes, toothpaste and gargle Deodorants, antiperspirants, bath additives, hygiene products, sanitary cotton class, external quasi drugs such as wet tissue, externally applied drugs and the like.

  In addition, it means beauty and health-oriented foods, beverages, and oral preparations in general. Ampoule, capsule, pill, tablet (pellet), powder, granule, solid, liquid, jelly (gel) or air bubble And so on. Specifically, nutrition supplementation, nourishing tonic, fatigue recovery, constitution improvement, whitening, skin beautification, anti-acne, beauty hair, hair growth / hair growth, anti-allergy and other beauty / health-oriented foods and beverages, gums, candy, Taste foods or beverages such as yogurt and soft drinks are raised.

  The neem extract content in the cosmetic composition according to the production method of the present invention is slightly different depending on the type, quality, and expected action of the cosmetic composition, and is not particularly limited. When converted to a content of about 0.0001 to 20% by mass, preferably about 0.01 to 10%, usability and good effects can be obtained. In the case of a bath preparation, the formulation may be considered so that it is poured into 200 to 300 L of hot water and has a concentration similar to the content defined in other cosmetic compositions.

  In addition to the above-mentioned essential components, the cosmetic composition of the present invention further includes a pigmentation inhibitor, a tyrosinase activity inhibitor, a melanocyte melanin production inhibitor, a moisturizer, and a cell activator / metabolic activation exemplified below. Agents, antioxidants, active oxygen scavengers / radical production inhibitors, fat metabolism promoters, UV protection agents / UV absorption promoters, astringents, anti-inflammatory agents / interleukin production inhibitors / anti-inflammatory agents, antiseborrheic agents , Antibacterial / antiviral agent, blood flow promoter / vascular stimulant, antiandrogen, structural proteolytic enzyme (elastase, collagenase, keratin protease, serine protease, integrin degrading enzyme, involucrin degrading enzyme, filaggrin degrading enzyme, laminin degrading enzyme Enzymes, fibronectin degrading enzymes, proteoglycan degrading enzymes, etc.) Activity inhibitors / structural proteolytic enzymes Current inhibitors, structural protein synthesis promoters, mucopolysaccharide (hyaluronic acid, chondroitin sulfate, etc.) degrading enzyme inhibitors, mucopolysaccharide synthesis promoters, intercellular lipid production promoters / intercellular lipid state improvers, keratolytic agents / Active ingredients such as stratum corneum exfoliation promoter, plasminogen activator antagonist inhibitor, Maillard reaction inhibitor, testosterone 5α reductase activity inhibitor, odorant elimination agent, and other forms of whitening agents or whitening cosmetics Components such as extracts and metabolites derived from plant-based materials, animal-based materials, microbial-based materials, and other natural product materials that are preferred for use in formation, or various compounds are arbitrarily selected and used as additives. Thus, in addition to the above-described various whitening effects, an excellent cosmetic composition having various functions can be provided. The content in the preparation is not particularly limited, but it is generally used in a concentration range of 0.0001 to 50% by weight.

(1) Pigmentation inhibitor
p-aminobenzoic acid derivatives, salicylic acid derivatives, benzenesulfonamide derivatives, imidazole derivatives, naphthalene derivatives, hydroxyanthranilic acid or its salts and derivatives thereof, anthranilic acid derivatives, coumarin derivatives, amino acid derivatives (2-amino-3- [ 1-carboxyl-2- (1H-imidazol-4-yl) ethyl] aminobutanoic acid, 2-amino-3- [1-carboxyl-2- (1H-imidazol-4-yl) ethyl] aminobutanoic acid Hydrochloride, 2-amino-3- [1-carboxyl-2- (1H-imidazol-4-yl) ethyl] aminobutanoic acid sodium salt, 2-amino-3- [1-carboxyl-2- (1H- Imidazol-4-yl) ethyl] aminobutanoic acid potassium salt, etc.), benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives , Furan derivatives, pyrone derivatives, nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives, ascorbic acid or salts thereof and derivatives thereof (phosphoric acid-magnesium ascorbate, ascorbyl palmitate, ascorbyl dipalmitate, hydroxyproline phosphorus ascorbate) Acid ester, 5-o-α-D-glucopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate sodium salt, L-ascorbic acid phosphate potassium salt, L-ascorbic acid phosphate magnesium salt, L- Ascorbic acid phosphate calcium salt, L-ascorbic acid phosphate aluminum salt, L-ascorbic acid sulfate sodium salt, L-ascorbic acid sulfate potassium salt, L-ascorbic acid sulfate magnesium salt, L-ascorbic acid sulfate Ester calcium salt, L-ascorbic acid sulfate aluminum salt, L-ascorbic acid sodium salt, L-ascorbic acid potassium salt, L-ascorbic acid magnesium salt, L-ascorbic acid calcium salt, L-ascorbic acid aluminum salt, 6- o-α-D-galactopyranosyl-L-ascorbic acid, 2-o-β-D-galactopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate Ester sodium salt, L-ascorbic acid sulfate sodium salt, 6-o-acyl ascorbic acid phosphate sodium salt, 6-o-acyl ascorbic acid phosphate ammonium salt, 6-o-acyl ascorbic acid phosphate isopropanol Amine salt, 3-o-isopropyl-L-ascorbic acid, 6-o-alkylascorbic acid phosphate Potassium salt, 6-o-alkylascorbic acid phosphate calcium salt, 6-o-alkylascorbic acid phosphate barium salt, 6-o-alkylascorbic acid phosphate ammonium salt, 6-o-alkylascorbic acid phosphate Acid ester monoethanolamine salt, 6-o-alkylascorbic acid phosphate diethanolamine salt, 6-o-alkylascorbic acid phosphate triethanolamine salt, 6-o-alkylascorbic acid phosphate monoisopropanolamine salt, 6-o-alkylascorbic acid phosphate diisopropanolamine salt, 6-o-alkylascorbic acid phosphate triisopropanolamine salt, 3-o-glycosyl-L-ascorbic acid, 6-o-β-D-galacto Pyranosyl-L-ascorbic acid, cholesterol ascorbyl phosphate Esters, palmitic acid-L-ascorbyl, isopalmitic acid-L-ascorbyl, dipalmitic acid-L-ascorbyl, diisopalmitic acid-L-ascorbyl, stearic acid-L-ascorbyl, isostearic acid-L-ascorbyl, distearic acid -L-ascorbyl, diisostearic acid-L-ascorbyl, myristic acid-L-ascorbyl, isomyristic acid-L-ascorbyl, dimyristic acid-L-ascorbyl, diisomyristic acid-L-ascorbyl, 2-ethylhexanoic acid- L-ascorbyl, di-2-ethylhexanoic acid-L-ascorbyl, oleic acid-L-ascorbic acid, 2-o-α-D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L -Ascorbic acid, 2-o-α-D-maltotriosyl-L-ascorbic acid, 3-o-α-D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid , 2-o-α-D-maru Triosyl-L-ascorbic acid, L-ascorbic acid tetraisopalmitic acid ester, L-ascorbic acid tetralauric acid ester, L-ascorbic acid tetra-2-ethylhexanoic acid ester, L-ascorbic acid tetraoleic acid ester, 5, 6-isopropylidene-L-ascorbic acid, L-ascorbic acid retinol ester, L-ascorbic acid-DL-tocopherol phosphate ester, L-3-o-ethylascorbic acid, L-ascorbic acid tristearate, L-ascorbine Acid tripalmitate, L-ascorbic acid trioleate, L-ascorbic acid triphosphate, 2-o-ascorbyl cinnamate, 2-o-ascorbyl ferrate, 2-o-ascorbyl caffeate, 2-o-ascorbyl cinna Pate, 2-o- [6-palmitoyl ascorbyl] -4'-acetoxyferrate, DL-α-toco Errol-2-L-ascorbic acid phosphoric diester, ascorbic acid inositol binding derivative, ascorbic acid phosphoramide derivative, ascorbyl arbutin conjugate, ascorbyl phosphoryl cholesterol, chromanyl ascorbic acid derivative, ascorbic acid sialic acid derivative, etc.), tocopherol or its Salts and derivatives thereof (α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, ε-tocopherol, α-tocopheryl retinoate, aminomethylated tocopherol, hydroxymethylated tocopherol, tocopheryl phosphate, tocopherol acetate , Tocopherol nicotinate, tocopherol succinate, tocopherol linoleate, tocopherol orotate, DL-α-tocopheryl glucoside, D L-α-tocopheryl maltoside, DL-β-tocopheryl glucoside, DL-β-tocopheryl maltoside, DL-γ-tocopheryl glucoside, DL-γ-tocopheryl maltoside, DL-δ-tocopheryl glucoside DL-δ-tocopheryl maltoside, D-α-tocopheryl glucoside, D-α-tocopheryl maltoside, D-β-tocopheryl glucoside, D-β-tocopheryl maltoside, D-γ-tocopheryl Glucoside, D-γ-tocopheryl maltoside, D-δ-tocopheryl glucoside, D-δ-tocopheryl maltoside, L-α-tocopheryl glucoside, L-α-tocopheryl maltoside, L-β-toco Ferryl glucoside, L-β-tocopheryl maltoside, L-γ-tocopheryl glucoside, L-γ-tocopheryl maltoside, L-δ-tocopheryl glucoside, L-δ-tocopheryl maltoside, 1- (sulfo Ethylamino) -3- (α-toco Eleyl-6-iroxy) propan-2-ol, 1- (carboxypropylamino) -3- (α-tocopheryl-6-iroxy) propan-2-ol hydrochloride, S- [3- (α-toco Ferroyl-6-iroxy) -2-hydroxypropyl] cysteine, S- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] -γ-glutamylcystenylglycine, N- [3- (Α-tocopheryl-6-iroxy) -2-hydroxypropyl] aspartic acid, N- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] glutamic acid, etc.), tocotrienol or a salt thereof And derivatives thereof (α-tocotrienol, β-tocotrienol, γ-tocotrienol, δ-tocotrienol, tocotrienol acetate, tocotrienol nicotinate, tocotrienol succinate, tocotrieno Lurinolate, tocotrienol orotate, etc.), kojic acid or derivatives thereof (2-methoxymethyl-hydroxy-4H-pyran-4-one, 2-ethoxymethyl-5-hydroxy-4H-pyran-4-one, 2-benzoluyl Oxymethyl-5-hydroxy-4H-pyran-4-one, 2-cinnamoyloxymethyl-5-hydroxy-4H-pyran-4-one, 2-phenoxymethyl-5-hydroxy-4H-pyran-4-one Kojic acid glycoside, geranylgeranylacetone, kojic acid monobutyrate, kojic acid monocaprate, kojic acid monopalmitate, kojic acid monostearate, kojic acid monocinnamate, kojic acid monobenzoate, kojic acid dibutyrate, kojic acid dipalmitate , Kojic acid distearate, kojic acid dioleate, etc.), oxybenzone, benzophenone, guaiazulene, shikonin, baika Or salts thereof and derivatives thereof, baicalein or salts thereof and derivatives thereof, berberine or salts thereof and derivatives thereof, chrysin or salts thereof and derivatives thereof, apigenin or salts thereof and derivatives thereof, luteolin or salts thereof and Derivatives thereof, acacetin or a salt thereof and derivatives thereof, diosmethine or a salt thereof and derivatives thereof, kaempferol or a salt thereof and derivatives thereof, triphorin or a salt thereof and derivatives thereof, astragalin or a salt thereof and derivatives thereof Quercetin or a salt thereof and derivatives thereof, quercitrin or a salt thereof and derivatives thereof, isoquercitrin or a salt thereof and derivatives thereof, rutin or a salt thereof and derivatives thereof, morin or a salt thereof and These derivatives, myricetin or a salt thereof and derivatives thereof, myricitrine or a salt thereof and derivatives thereof, datiscetin or a salt thereof and derivatives thereof, quercetagetin or a salt thereof and derivatives thereof, isorhamnetin or a salt thereof and derivatives thereof , Pinocembrin or a salt thereof and derivatives thereof, naringenin or a salt thereof and derivatives thereof, hesperetin or a salt thereof and derivatives thereof, eriodictyol or a salt thereof and derivatives thereof, pinobankin or a salt thereof and derivatives thereof, aromaden Dorin or a salt thereof and derivatives thereof, engelitin or a salt thereof and derivatives thereof, taxofolin or a salt thereof and derivatives thereof, astilbine or a salt thereof and derivatives thereof, amperopsin or Salts thereof and derivatives thereof, glutathione or salts thereof and derivatives thereof, isoflavone glycosides (6-o-apiosyl puerarin-4′-o-glucoside, 6-o-glucosyl puerarin, 3′-hydroxy puerarin-4 '-o-glucoside, 6-o-apiosyl-3'-hydroxypuerarin, etc.), γ-pyrone glycoside (maltol-3-o- (6'-o-apiosyl) -glucoside, maltol-3-o- (6'-o-apiosyl) -glucoside, etc.), isononyl ferrate, ellagic acid or its salts and derivatives thereof (5,4-dimethylellagic acid, 3,3'-dimethylellagic acid, 3,3 ', 4-trimethylellagic acid, 3,3 ', 4,4'-tetramethyl-5-methoxyellagic acid, 3-ethyl-4-methyl-5-hydroxyellagic acid, amritoside, etc.), lucinol, ondisaponin, bacmond Usaponin, Ruscogenin, Celicoside, Asian Chicoside, F Deline, Senegin, Benzoic acid anilides (4-hydroxy-N- (2-hydroxyphenyl) benzoic acid amide, 4-hydroxy-N- (3-hydroxyphenyl) benzamide, 4-hydroxy-N- (4-hydroxyphenyl) ) Benzamide, 3,5-di-t-butyl-4-hydroxy-N- (4-hydroxyphenyl) benzamide, 3,5-di-t-butyl-4-hydroxy-N- (3-hydroxyphenyl) benzamide , 3,5-di-t-butyl-4-hydroxy-N- (2-hydroxyphenyl) benzamide, etc.), diphenylpyraline, cyproheptadine, triprolysine, dimethindene, ozagrel, istipendyl, iproheptin, homochlorcyclidine, alimemazine, Bucillamine, oxytosamide, vidarabine, xanthotoxol, phenylmercury hexachlorophene, mercuric oxide, mercuric chloride, hydrogen peroxide Zinc peroxide, placenta (bovine origin, pig origin, horse origin, sheep origin, etc.) extract, almond extract, amaranth extract, octopus extract, lobster extract, querca extract, kofuyou extract, uncaria extract , Geijicha extract, citrus extract, licorice extract, gardenia extract, cranigean extract, clara extract, koganebana (ougon) extract, wheat (wheat) extract, rice (rice) extract, Koreaia extract, Sidwaya extract, sunflower Cucumber extract, Sanvitro extract, Sunpens extract, Silane (river cucumber) extract, Senkyu (river cucumber) extract, Senna extract, Senpukuka extract, Sentsutsusai extract, Surigatin extract, Nodake (maehu) extract, pearl barley (yokuinin) Extract, Hamagoueki , Honey beetle extract, clam extract, palm extract, parietalia extract, safflower extract, mugwort extract, malvanojadin extract, purple squirrel extract, white squirrels extract, moko Artemisia extract, yashajitsu extract, hongkong extract, bituminous extract, ground lily extract, citrus extract, millipede extract, etc.

(2) Tyrosinase activity inhibitor Ascorbic acid or its salts and derivatives thereof (phosphate-L-ascorbic acid magnesium, ascorbyl palmitate, ascorbyl dipalmitate, ascorbyl hydroxyprophosphate ester, 5-o-α-D -Glucopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate sodium salt, L-ascorbic acid phosphate potassium salt, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate calcium salt, L- Ascorbic acid phosphate aluminum salt, L-ascorbic acid sodium salt, L-ascorbic acid potassium salt, L-ascorbic acid sulfate magnesium salt, L-ascorbic acid sulfate calcium salt, L-ascorbic acid sulfate Aluminum Nium salt, L-ascorbic acid sodium salt, L-ascorbic acid potassium salt, L-ascorbic acid magnesium salt, L-ascorbic acid calcium salt, L-ascorbic acid aluminum salt, 6-o-α-D-galactopyranosyl -L-ascorbic acid, 2-o-β-D-galactopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate sodium salt, L-ascorbic acid sulfate Sodium salt, 6-o-acyl ascorbic acid phosphate sodium salt, 6-o-acyl ascorbic acid phosphate ammonium salt, 6-o-acyl ascorbic acid phosphate isopropanolamine salt, 3-o-isopropyl-L -Ascorbic acid, 6-o-alkylascorbic acid potassium phosphate, 6-o-alkylascorbic acid phosphate calcium Um salt, 6-o-alkyl ascorbic acid phosphate barium salt, 6-o-alkyl ascorbic acid phosphate ammonium salt, 6-o-alkyl ascorbic acid phosphate monoethanolamine salt, 6-o-alkyl ascorbine Acid phosphate ester diethanolamine salt, 6-o-alkylascorbic acid phosphate triethanolamine salt, 6-o-alkylascorbic acid phosphate monoisopropanolamine salt, 6-o-alkylascorbic acid phosphate diisopropanolamine Salt, 6-o-alkylascorbic acid phosphate triisopropanolamine salt, 3-o-glycosyl-L-ascorbic acid, 6-o-β-D-galactopyranosyl-L-ascorbic acid, ascorbic acid phosphate Cholesterol ester, palmitic acid-L-ascorbyl, isopalmitic acid-L- Scorbyl, dipalmitic acid-L-ascorbyl, diisopalmitic acid-L-ascorbyl, stearic acid-L-ascorbyl, isostearic acid-L-ascorbyl, distearic acid-L-ascorbyl, diisostearic acid-L-ascorbyl, myristic acid- L-ascorbyl, isomyristic acid-L-ascorbyl, dimyristic acid-L-ascorbyl, diisomyristic acid-L-ascorbyl, 2-ethylhexanoic acid-L-ascorbyl, di-2-ethylhexanoic acid-L-ascorbyl , Oleic acid-L-ascorbic acid, 2-o-α-D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α-D-maltotriosyl -L-ascorbic acid, 3-o-α-D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α-D-maltotriosyl-L- Ascorbic acid, L-ascorbic acid tetraisopa Mycinate, L-ascorbate tetralaurate, L-ascorbate tetra-2-ethylhexanoate, L-ascorbate tetraoleate, 5,6-isopropylidene-L-ascorbate, L-ascorbine Acid retinol ester, L-ascorbic acid-DL-tocopherol phosphate ester, L-3-o-ethylascorbic acid, L-ascorbic acid tristearate, L-ascorbic acid tripalmitate, L-ascorbic acid trioleate, L -Ascorbyl triphosphate, 2-o-ascorbyl cinnamate, 2-o-ascorbyl ferrate, 2-o-ascorbyl caffeate, 2-o-ascorbyl synapate, 2-o- [6-palmitoyl ascorbyl]- 4'-acetoxyferrate, DL-α-tocopherol-2-L-ascorbic acid phosphate diester, ascorbine Inositol-binding derivatives, ascorbic acid phosphoramide derivatives, ascorbic acid arbutin conjugates, ascorbyl phosphoryl cholesterol, chromanyl ascorbic acid derivatives, ascorbic acid sialic acid derivatives, etc.), hydroquinone or its salts and their derivatives (hydroquinone α-D-glucose, hydroquinone) β-D-glucose, hydroquinone α-L-glucose, hydroquinone β-L-glucose, hydroquinone α-D-galactose, hydroquinone β-D-galactose, hydroquinone α-L-galactose, hydroquinone β-L-galactose, etc. Carbohydrate glycosides, hydroquinone α-D-ribose, hydroquinone β-D-ribose, hydroquinone α-L-ribose, hydroquinone β-L-ribose, hydroquinone α-D-arabinose, hydroquinone β-D-arabinose , 5-quinone sugar glycosides such as hydroquinone α-L-arabinose and hydroquinone β-L-arabinose, hydroquinone α-D-glucosamine, hydroquinone β-D-glucosamine, hydroquinone α-L-glucosamine, hydroquinone β-L-glucosamine , Hydroquinone α-D-galactosamine, hydroquinone β-D-galactosamine, hydroquinone α-L-galactosamine, hydroquinone β-L-galactosamine and other amino sugar glycosides, hydroquinone α-D-glucuronic acid, hydroquinone β-D-glucuron Acids, hydroquinone α-L-glucuronic acid, hydroquinone β-L-glucuronic acid, hydroquinone α-D-galacturonic acid, hydroquinone β-D-galacturonic acid, hydroquinone α-L-galacturonic acid, hydroquinone β-L-galacturonic acid, etc. Hydroquinone glycosides such as uronic acid glycosides, hydro Quinone benzyl ether, 4-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) butane, 5-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) pentane, 6- β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) hexane, 2-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) propane, 2-β-D-glucopyra Hydroquinone hydroxyalkyl ether glycosides such as nosyloxy-1- (4-hydroxyphenoxy) butane and 2-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) propan-3-ol) , Kojic acid or salts thereof and derivatives thereof (2-methoxymethyl-hydroxy-4H-pyran-4-one, 2-ethoxymethyl-5-hydroxy-4H-pyran-4-one, 2-benzoyloxymethyl- 5-Hydroxy-4H-pyran-4-one, 2-cinnamoyloxy Til-5-hydroxy-4H-pyran-4-one, 2-phenoxymethyl-5-hydroxy-4H-pyran-4-one, kojic acid glycoside, geranylgeranylacetone, kojic acid monobutyrate, kojic acid monocaprate, kouji Acid monopalmitate, kojic acid monostearate, kojic acid monocinnamate, kojic acid monobenzoate, kojic acid dibutyrate, kojic acid dipalmitate, kojic acid distearate, kojic acid dioleate, etc.), tocopherol or salts thereof and derivatives thereof (α -Tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, ε-tocopherol, α-tocopheryl retinoate, aminomethylated tocopherol, hydroxymethylated tocopherol, tocopheryl phosphate, tocopherol acetate, tocopherol ni Tinate, tocopherol succinate, tocopherol linoleate, tocopherol orotate, DL-α-tocopheryl glucoside, DL-α-tocopheryl maltoside, DL-β-tocopheryl glucoside, DL-β-tocopheryl maltoside, DL- γ-tocopheryl glucoside, DL-γ-tocopheryl maltoside, DL-δ-tocopheryl glucoside, DL-δ-tocopheryl maltoside, D-α-tocopheryl glucoside, D-α-tocopheryl maltoside, D -β-tocopheryl glucoside, D-β-tocopheryl maltoside, D-γ-tocopheryl glucoside, D-γ-tocopheryl maltoside, D-δ-tocopheryl glucoside, D-δ-tocopheryl maltoside, L-α-tocopheryl glucoside, L-α-tocopheryl maltoside, L-β-tocopheryl glucoside, L-β-tocopheryl maltoside, L-γ-tocopheryl glucoside L-γ-tocopheryl maltoside, L-δ-tocopheryl glucoside, L-δ-tocopheryl maltoside, L- (sulfoethylamino) -3- (α-tocopheryl-6-iroxy) propane -2-ol, 1- (carboxypropylamino) -3- (α-tocopheryl-6-iroxy) propan-2-ol hydrochloride, S- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] cysteine, S- [3- (α-tocopheryl-6-yloxy) -2-hydroxypropyl] -γ-glutamylcystenylglycine, N- [3- (α-tocopheryl- 6-Iroxy) -2-hydroxypropyl] aspartic acid, N- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] glutamic acid, etc.), tocotrienol or its salts and derivatives thereof (α- Tocotrienol, β-tocotrienol, γ-tocotrienol δ-tocotrienol, tocotrienol acetate, tocotrienol nicotinate, tocotrienol succinate, tocotrienol linoleate, tocotrienol orotate, etc.), N-acetyltyrosine or a salt thereof and derivatives thereof, glutathione or a salt thereof and derivatives thereof, ellagic acid or a derivative thereof Salts and derivatives thereof (3,4-dimethylellagic acid, 3,3'-dimethylellagic acid, 3,3 ', 4-trimethylellagic acid, 3,3', 4,4'-tetramethyl-5-methoxy Isonitrile antibiotics such as ellagic acid, 3-ethyl-4-methyl-5-hydroxyellagic acid, amritoside, etc.), isonitrine A, isonitrine B, isonitrine C, isonitrine D, isonitrinic acid E, isonitrinic acid F, dermadein, tricobilidene Substance, orthoric acid derivative (orceric acid, orthophosphoric acid Tylester orcinol, p-geranylorceric acid, p-geranylorceric acid ethyl estergeranylorcinol, p-farnesylorselinic acid, p-farnesylorceric acid ethylester farnesylorcinol, p-dodecanylorceric acid P-dodecanylorceric acid ethyl ester dodecanylorcinol, p-tetradecanylorceric acid, p-tetradecanylorceric acid ethylester tetradecanylorcinol, p-hexadecanylorceric acid, p -Hexadecanylorceric acid ethyl ester hexadecanylorcinol, p-undecanylorceric acid, p-undecanylorceric acid ethylester undecanylorcinol, p-tridecanylorceric acid, p- Tridecanylorceric acid ethyl ester undecanylorcinol , P-pentadecanylorceric acid, p-pentadecanylorceric acid ethyl ester pentadecanylorcinol, ethylhexylorselinic acid, p-ethylhexylorceric acid ethylester ethylhexylorcinol, p-cyclohexylmethylorceric acid P-cyclohexylmethylorceric acid ethyl ester cyclohexylmethylorcinol, p-hydroxyethylhexylorceric acid methyl ester, p-hydroxyethylhexylorceric acid hydroxyethylhexylorcinol, etc.), umbelic acid, brefeldin, oxydesveratrol , Resorcinol derivatives (4-cyclohexylresorcinol), 3-hydroxyketone compounds (1,5-bis (p-hydroxyphenyl) -2-hydroxypentan-4-one, 1,5-bis (o, p-dihydroxyph) Nyl) -2-hydroxypentan-4-one, 1,5-bis (p-hydroxyphenyl-m-methoxyphenyl) -2-hydroxypentan-4-one, etc.), 1,3-diketone compounds (1,5 -Bis (p-hydroxyphenyl) -2,4-pentanedione, 1,5-bis (o, p-dihydroxyphenyl) -2,4-pentanedione, 1,5-bis (p-hydroxyphenyl-m- Methoxyphenyl) -2,4-pentanedione), bishydroxybenzyl amides, γ-aminobutyric acid or its derivatives (N-methyl-γ-aminobutyric acid, N-dimethyl-γ-aminobutyric acid, oleyl γ-aminobutyric acid) Esters, etc.), hydrogen peroxide, zinc peroxide, placenta extract, lucinol, silk extract, acacia extract, acerola extract, ichibi (winter position) extract, weeping birch extract, quercus (gallic) extract, chestnut extract, kamebahikokoshiki extract, kurobanahiokikoshi Extract, Hikikoshi (life extension grass) extract, Seri extract, Buckwheat extract, Davilia extract, Nazuna extract, Fujibakama (Orchid grass) extract, Chamomile extract, Mulberry extract, Gardenia extract, Japanese cypress extract, Walnut extract, Clara extract, Artemisia extract, Honeysuckle extract, Yellowfin Extract, Bokudami extract, Matsuhodo extract, pearl barley extract, nettle extract, hop extract, hawthorn extract, eucalyptus extract, yarrow extract, altea extract, cinnamon extract, bay extract, hamameris extract, yamagwa extract, bellflower extract, toshishi extract Extract, dry-boiled extract, mahuang extract, senkyu extract, dokkatsu extract, psycho extract, bowfish extract, hamaboufu extract, ougon extract, peony skin extract, peonies Kiss, cranesbill extract, kudzu root extract, licorice extract, gallnut extract, aloe extract, Cimicifuga extract, safflower extract, green tea extract, black tea extract, Ali elixir extract, and the like.

(3) Melanocyte melanin production inhibitor
Lobeline or lobeline derivatives, liquiritin derivatives (such as liquiritin-α-glucoside, liquiritin-α-maltoside), phenylchroman derivatives, chromone derivatives (2-butylchromone, 2-pentylchromone, 2-heptylchromone, 2-nonylchromone, 2- Hexadecylchromone, 2- (1-ethylpentyl) chromone, 2-butyl-7-methoxychromone, 2-pentyl-7-methoxychromone, 2-heptyl-7-methoxychromone, 2-nonyl-7-methoxychromone, 2-pentadecyl-7-methoxychromone, 2- (1-ethylpentyl) -7-methoxychromone, 7-hydroxy-2-methylchromone, 7-hydroxy-2-butylchromone, 7-hydroxy-2-pentylchromone, 7-hydroxy-2-heptylchromone, 7-hydroxy-2-nonylchromone, 7-hydroxy-2-pentadecylchromone, 7-hydroxy-2- (1-ethyl) Rupentyl) chromone), azelaic acid derivatives (azelaic acid monoalkyl ester, azelaic acid dialkyl ester, etc.), phosphatidylglucosamine, lysophosphatidylglucosamine, phenylhydroquinone, 3-β-D-glucopyranosyl manur, 3-β-D -Maltopyranosyl manur, substituted amino acid derivatives (DL-N-formyl-3- (1-naphthyl) alanine, DL-N-acetyl-3- (1-naphthyl) alanine, DL-N-propionyl-3- ( 1-naphthyl) alanine, DL-N-butyryl-3- (1-naphthyl) alanine, DL-N-isobutyryl-3- (1-naphthyl) alanine, DL-N-valeryl-3- (1-naphthyl) alanine DL-N-isovaleryl-3- (1-naphthyl) alanine, DL-N- (2-methylvaleryl) -3- (1-naphthyl) alanine, DL-N- (3-methylvaleryl) -3- (1- Naphthyl) alanine, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine, DL-N-t-butylacetyl-3- (1-naphthyl) alanine, DL-N-pivaloyl-3- (1-naphthyl) alanine, DL-N-caproyl-3 -(1-naphthyl) alanine, DL-N- (2-ethylhexanoyl) -3- (1-naphthyl) alanine, DL-N- (2-methylhexanoyl) -3- (1-naphthyl) alanine, DL-N-Heptanoyl-3- (1-naphthyl) alanine, DL-N-octanoyl-3- (1-naphthyl) alanine, DL-N- (2-propylpentanoyl) -3- (1-naphthyl) alanine DL-N-nonanoyl-3- (1-naphthyl) alanine, DL-N-decanoyl-3- (1-naphthyl) alanine, DL-N-undecanoyl-3- (1-naphthyl) alanine, DL-N- Dodecanoyl-3- (1-naphthyl) alanine, DL-N-tridecanoyl-3- (1-naphthyl) alanine, DL-N-tetradecanoyl-3- (1-naphthyl) alanine, DL-N-pentadecanoyl -3- (1-Naph ) Alanine, DL-N-hexadecanoyl-3- (1-naphthyl) alanine, DL-N-heptadecanoyl-3- (1-naphthyl) alanine, DL-N-octadecanoyl-3- (1-naphthyl) ) Alanine, DL-N-nonadecanoyl-DL-3- (1-naphthyl) alanine, DL-N-icosanoyl-3- (1-naphthyl) alanine, DL-N-acroyl-3- (1-naphthyl) alanine, DL-N-crotoniloyl-3- (1-naphthyl) alanine, DL-N-methacryloyl-3- (1-naphthyl) alanine, DL-N-vinylacetyl-3- (1-naphthyl) alanine, DL-N- Cyclopropanoyl-3- (1-naphthyl) alanine, DL-N- (2-pentenoyl) -3- (1-naphthyl) alanine, DL-N- (4-pentenoyl) -3- (1-naphthyl) alanine DL-N- (2-hexenoyl) -3- (1-naphthyl) alanine, DL-N- (3-hexenoyl) -3- (1-naphthyl) alanine, DL-N- (2-methyl-3- Pentenoyl) -3- (1- Naphthyl) alanine, DL-N-cyclohexenoyl-3- (1-naphthyl) alanine, DL-N- (10-undecenoyl) -3- (1-naphthyl) alanine, DL-N-linoleyl-3- (1-naphthyl) alanine, DL-N-hydroxyacetyl-3- (1-naphthyl) alanine, DL-N- (6-hydroxycaproyl) -3- (1-naphthyl) alanine, DL-N- (8 -Hydroxyoctanoyl) -3- (1-naphthyl) alanine, DL-N- (9-hydroxynonanoyl) -3- (1-naphthyl) alanine, DL-N- (10-hydroxydecanoyl) -3- (1-naphthyl) alanine, DL-N- (11-hydroxyundecanoyl) -3- (1-naphthyl) alanine, DL-N- (12-hydroxydecanoyl) -3- (1-naphthyl) alanine, DL-N-benzoyl-3- (1-naphthyl) alanine, DL-N- (2-hydroxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (3-hydroxybenzoyl) -3- (1 -Naph ) Alanine, DL-N- (4-hydroxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (o-toluyl) -3- (1-naphthyl) alanine, DL-N- (m- Toluyl) -3- (1-naphthyl) alanine, DL-N- (p-toluyl) -3- (1-naphthyl) alanine, DL-N- (1-naphthoyl) -3- (1-naphthyl) alanine, DL-N- (2-naphthoyl) -3- (1-naphthyl) alanine, DL-N- (2-carboxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (3-carboxybenzoyl)- 3- (1-Naphtyl) alanine, DL-N- (4-Carboxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (2-Picolyloyl) -3- (1-naphthyl) alanine, DL- N- (3-picolineoyl) -3- (1-naphthyl) alanine, DL-N- (4-picolineoyl) -3- (1-naphthyl) alanine, DL-N-phenylacetyl-3- (1-naphthyl) Alanine, DL-N- (2-Phenylpropanoyl) -3- (1-naphth ) Alanine, DL-N- (3-phenylbutyryl) -3- (1-naphthyl) alanine, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine, DL-N-valeryl- 3- (1-naphthyl) alanine, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alaninamide, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine methyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine ethyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine propyl ester, DL-N- (4-methylvaleryl) ) -3- (1-naphthyl) alanine-N-butyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine pentyl ester, DL-N- (4-methylvaleryl) -3- ( 1-naphthyl) alanine isopropyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine isobutyl ester, DL-N- (4-methyl) Valeryl) -3- (1-naphthyl) alanine-t-butyl ester), benzolactam derivatives, indolactam derivatives, cedrol, guaioles, 1- (4-hydroxyphenithio) -2-propanol, β-lactoglobulin, 2-methoxy-5-methylphenol, 5-ethyl-2-methoxyphenol, 5-N-propyl-2-methoxyphenol, 5-N-butyl-2-methoxyphenol, 5-N-hexyl-2-methoxyphenol , 5-N-heptyl-2-methoxyphenol, 5-N-decyl-2-methoxyphenol, 5- (1,1-dimethylpropyl) -2-methoxyphenol, 5- (1,1-dimethylbutyl)- 2-methoxyphenol, 5- (1,1-dimethylethyl) -2-methoxyphenol, 2-methoxy-5- (1-methylpentyl) phenol, 2-methoxy-5- (1-methylhexyl) phenol, 2 -Methoxy-5- (3-methylhexyl) pheno , 2-methoxy-5- (6-methylheptyl) phenol, 5- (1,3-dimethylheptyl) -2-methoxyphenol, malvelin, ferguinol, sugiol, cryptojaponol, 1,5-bis [p-hydroxyl Phenyl] -1,4-pentadien-3-one, 1,5-bis [o-hydroxyphenyl] -1,4-pentadien-3-one, 1,5-bis [2,4-dihydroxyphenyl]- 1,4-pentadien-3-one, 1,5-bis [3-methoxy-4-hydroxyphenyl] -1,4-pentadien-3-one, haginin, agrimophor, agrimol, hydrangenol or a derivative thereof, Alkylresorcinol or its derivatives (4-N-butylresorcinol, etc.), Aristolone, Caramenene (Caramenen, 7-hydroxycaramenene, 5-hydroxycaramenene, 7-methoxycaramenen, etc.), trans-umbellic acid, N- α-be Zoyl-L-arginine, N-α-benzoyl-L-arginine ethyl ester or N-α-benzoyl-L-arginine ethyl ester, 5-methyl-2 (3H) -furanone, 2-butene-4-olide, 2 -Hydroxymethylfuran, 2,5-dimethyl-4-hydroxy-3 (2H) -furanone, 2-formylfuran, 3-formylfuran, methyl α-furyl ketone, furfuryl acetate, 2-hydroxy-3-methyl-2 -Cyclopenten-1-one, 2-hydroxy-3,5-dimethyl-2-cyclopenten-1-one, 2,5-dimethyl-4-hydroxy-3 (2H) -thiophenone, 2-hydroxy-3-ethyl- 2-cyclopenten-1-one, tetronic acid, pentanedione, iminodibenzyls (2,2'-iminodibenzyl, imipramine, imipramine hydrochloride, desipramine, desipramine hydrochloride, chlorimipramine, trimipramine, etc.), dibenzocycloheptadiene Kind ( Amitriptyline, amitriptyline hydrochloride, nortriptyline, noxypetitin, etc.), tetrahydrocopalol glycosides (ketotifen fumarate, labda-8 (17), 13-dien-15-ol, tetrahydromanol, tetrahydrocoparol, tetrahydrocoparalol glucoside) , Tetrahydrocoparol galactoside, tetrahydrocoparol maltoside, tetrahydrocoparol cellobioside, tetrahydrocoparol maltotrioside, etc.), spiro ether compound, piochelin, phenothiazine compound, promethazine, alimemazine, alimemazine tartrate, triflupromazine, levomepromazine, Chlorpromazine, cyclandelate, 4-carboxymethyloxybenzoic acid, 4-carboxymethyloxy-2-hydroxybenzoic acid, 3- (3-carboxypro Ru-1-oxy) -2-hydroxybenzoic acid, 4- (3-carboxypropyl-1-oxy) benzoic acid, 4- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- ( 3-carboxypropyl-1-oxy) -2-methoxybenzoic acid, 5- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (5-carboxypentyl-1-oxy) -2- Hydroxybenzoic acid, 6- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (10-carboxydecane-1-oxy) -2-hydroxybenzoic acid, 4- (10-carbamoyldecane- 1-oxy) -2-hydroxybenzoic acid, 4- (4-hydroxybutyl-1-oxy) benzoic acid, 4- (4-hydroxybutyl-1-oxy) -2-hydroxybenzoic acid, 4- (4- Acetoxybutyl-1-oxy) benzoic acid, 4- (4-acetoxybutyl-1-oxy) -2-hydroxybenzoic acid, 4- (3-ethoxycarboni) Propyl-1-oxy) -2-hydroxybenzoic acid, 3- (2,3-dihydroxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (4-methoxybutyl-1-oxy) -2-hydroxy Benzoic acid, 4- (2,3-dihydroxypropyl-1-oxy) -2-hydroxybenzoic acid, 4-carboxymethyloxy-2-hydroxybenzoic acid, 3- (3-carboxypropyl-1-oxy) -2 -Hydroxybenzoic acid, 4- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 5- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 6- (3-carboxypropyl) -1-oxy) -2-hydroxybenzoic acid, 4- (5-carboxypentyl-1-oxy) -2-hydroxybenzoic acid, 4- (4-hydroxybutyl-1-oxy) -2-hydroxybenzoic acid, 4- (10-carboxydecane-1-oxy) -2-hydroxybenzoic acid, hydroxytrimethylcyclohexa (2-hydroxy-4- (2,2,6-trimethyl-1-yl-cyclohexane) butane, 4- (2,2,6-trimethyl-1-yl-cyclohexane) -1-butene, 4- ( 2,2,6-trimethyl-1-yl-cyclohexane) -2-butene, 4- (2,2,6-trimethyl-1-yl-cyclohexane) butane, 3-methyl-3-hydroxy-5- (2 , 2,6-Trimethyl-1-yl-cyclohexane) pentane, 3-methyl-1-hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane) pentane, 3-methyl-5- (2 , 2,6-Trimethyl-1-yl-cyclohexane) pentane, 3-methyl-1-hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane) -3-pentene, 3-methyl-3 -Hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane) -1-pentene, 3-methyl-1-hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane) -2-pentene, 2-hydroxy-4- (2,2,6-trimethyl Til-1-yl-cyclohexane) butane and other monosaccharides, disaccharides or trisaccharide glycosides, etc., escinol, parahydroxycinnamic acid-4- (2,2,6-trimethyl-yl-cyclohexane) -2- Butyl ester monosaccharide, disaccharide or trisaccharide glycoside, ondisaponin, bacmond saponin, ruscogenin, sericoside, asiaticoside, hederin, senegin, 4- (2,2,6-trimethyl-1-yl-
Cyclohexane) -2-keto-butane, 4- (2,2,6-trimethyl-1-yl-6-cyclohexene) -2-keto-butane, 4- (2,2,6-trimethyl-1-yl- Cyclohexane) -2-keto-3-butene, 4- (2,2,6-trimethyl-1-yl-6-cyclohexene) -2-keto-3-butene (β-ionone), Lp-hydroxyphenylglycine, Dp-hydroxyphenylglycine, N-benzyloxycarbonyl-Lp-hydroxyphenylglycine, N-benzyloxycarbonyl-Dp-hydroxyphenylglycine, N-benzoyl-Lp-hydroxyphenylglycine, N-benzoyl-Dp-hydroxyphenylglycine, N- (p-methoxybenzoyl) -Lp-hydroxyphenylglycine, N- (p-methoxybenzoyl) -Dp-hydroxyphenylglycine, N- (p-hydroxybenzoyl) -Lp-hydroxyphenylglycine, N- (p- Hydroxybenzoyl) -Dp -Hydroxyphenylglycine, N-acetyl-Lp-hydroxyphenylglycine, N-acetyl-Dp-hydroxyphenylglycine, N-acetyl-Lp-hydroxyphenylglycine ethyl ester, N-acetyl-Dp-hydroxyphenylglycine ethyl ester, N -Acetyl-Lp-hydroxyphenylglycinamide, N-acetyl-Dp-hydroxyphenylglycinamide, Lp-methoxyphenylglycine, Dp-methoxyphenylglycine, Lp-methoxyphenylglycine hydrochloride, Dp-methoxyphenylglycine hydrochloride, 4 -Hydroxy-3-methoxy-L-phenylglycine, 4-hydroxy-3-methoxy-D-phenylglycine, Lp-hydroxyphenylglycine ethylamide, Dp-hydroxyphenylglycine ethylamide, N-tert-butoxycarbonyl-Lp- Hydroxyphenylglycine, N-tert-butoxy Carbonyl-Dp-hydroxyphenylglycine, N-tert-butoxycarbonyl-Lp-methoxyphenylglycine, N-tert-butoxycarbonyl-Dp-methoxyphenylglycine, N-9-fluorenylmethyloxycarbonyl-Lp-methoxyphenylglycine N-9-fluorenylmethyloxycarbonyl-Dp-methoxyphenylglycine, N-9-fluorenylmethyloxycarbonyl-Lp-methoxyphenylglycine benzyl ester hydrochloride, N-9-fluorenylmethyloxycarbonyl- Dp-methoxyphenylglycine benzyl ester hydrochloride, Lp-hydroxyphenylglycinamide, Dp-hydroxyphenylglycinamide, Lp-hydroxyphenylglycine allyl ester p-toluenesulfonate, Dp-hydroxyphenylglycine allyl ester p-toluenesulfonic acid Salt, Lp-hydroxyl Nylglycine benzyl ester p-toluenesulfonate, Dp-hydroxyphenylglycine benzyl ester p-toluenesulfonate, Lp-hydroxyphenylglycine ethyl ester, Dp-hydroxyphenylglycine ethyl ester, Lp-hydroxyphenylglycine ethyl ester hydrochloride , Dp-hydroxyphenylglycine ethyl ester hydrochloride, Lp-hydroxyphenylglycine methyl ester, Dp-hydroxyphenylglycine methyl ester, etc., 1,3-diallylindane-2-carboxylic acids, stachybocins, pheophorbide derivatives, eleucerin, isoeleucerine or 4-β-hydroxyisoeleucerin, eleucerinol, spiroketal derivatives (2- (2,4-hexadinylidene) -1,6-dioxaspiro [4.5] dec-3-ene, 2- (2-hexynylidene)- 1,6-Geo Oxaspiro [4.4] non-3-ene, 2-((4-methylphenyl) methylidene) -6,6-dioxaspiro [4.4] non-3-ene, 2- (2-hexenylidene) -6,6-dioxaspiro [ 4.5] Dec-3-ene, 2- (2-hexenylidene) -1,6-dioxaspiro [4.4] non-3-ene, 2-hexyl-1,6-dioxaspiro [4.4] nonane, 2- (2-hexenyl ) -1,6-dioxaspiro [4.4] nonane, 2- (2-hexynyl) -1,6-dioxaspiro [4.4] nonane, 2-pentyl-1,6-dioxaspiro [4.4] nonane, 1,6-dioxaspiro [ 4.4] nonane, 1,6-dioxaspiro [4.5] decane, 1,7-dioxaspiro [5.5] undecane, 2,3-benzo-4,4-dimethyl-1,6-dioxaspiro [4.4] nonane, 3,4- Benzo-2-pentyl-1,6-dioxaspiro [4.4] nonane, 3,4-benzo-2-hexyl-1,6-dioxaspiro [4.4] nonane, 3,4-benzo-2-octyl-1,6- Dioxas Pyro [4.4] nonane, 2-hexyl-9,9-dimethyl-1,6-dioxaspiro [4.4] nonane, 2- (2,4-hexadinylidene) -1,6-dioxaspiro [4.4] non-3- Ene, etc.), malvalic acid, phosphonic acid derivative or salt thereof, aspergillomalasmin, aminophosphonic acid derivative or salt thereof, diphenhydramine or salt thereof, pregnenolone or derivative thereof, lutein, farnesyl isopropanol derivative, hexahydrofarnesyl acetone, 4- Benzoylamino-2-hydroxybenzoic acid, 5-benzoylamino-2-hydroxybenzoic acid, 4-benzoylaminobenzoic acid, 4- (1-naphthoylamino) -2-hydroxybenzoic acid, 5- (1-naphthoyl) Amino) -2-hydroxybenzoic acid, 4- (2-naphthoylamino) -2-hydroxybenzoic acid, 5- (2-naphthoylamino) -2-hydroxybenzoic acid, 4- (1-na Futoylamino) benzoic acid, 4- (2-naphthoylamino) benzoic acid, 4-phenylaminocarbonylbenzoic acid, 4-phenylaminocarbonyl-2-hydroxybenzoic acid, 5-phenylaminocarbonyl-2-hydroxybenzoic acid, 4 -(1-naphthylaminocarbonyl) benzoic acid, 4- (1-naphthylaminocarbonyl) -2-hydroxybenzoic acid, 5- (1-naphthylaminocarbonyl) -2-hydroxybenzoic acid, 4- (2-naphthylamino) Carbonyl) benzoic acid, 4- (2-naphthylaminocarbonyl) -2-hydroxybenzoic acid, 5- (2-naphthylaminocarbonyl) -2-hydroxybenzoic acid, hexahydrofarnesyl isopropanol derivative, borneol-p-hydroxycinnamic Acid ester glucoside, borneol-p-hydroxycinnamic ester maltoside, borneol-p-hydroxycinnamic acid Stemaltotrioside, cinnamic acid-4- (2,2,6-trimethyl-yl-cyclohexane) -2-butyl ester derivative, 2,4-dihydroxybenzophenone, 1- (2,4-dihydroxyphenyl) -ethanone ( 2 ', 4'-dihydroxyacetophenone), 1- (2,4-dihydroxyphenyl) -1-propanone (2', 4'-dihydroxypropiophenone), 1- (2,4-dihydroxyphenyl) -1- Butanone, 1- (2,4-dihydroxyphenyl) -1-pentanone, 1- (2,4-dihydroxyphenyl) -1-hexanone, 1- (2,4-dihydroxyphenyl) -1-heptanone, 1- ( 2,4-dihydroxyphenyl) -1-octanone, 1- (2,4-dihydroxyphenyl) -1-nonanone, 1- (2,4-dihydroxyphenyl) -1-decanone, 1- (2,4-dihydroxy Phenyl) -1-undecanone, 1- (2,4-dihydroxyphenyl) -1-dodecanone, 1- (2,4-dihydroxy) Phenyl) -1-tetradecanone, 1- (2,4-dihydroxyphenyl) -1-hexadecanone, 1- (2,4-dihydroxyphenyl) -1-octadecanone, 1- (2-hydroxy-4-methoxyphenyl)- Etanone (2'-hydroxy-4'-methoxyacetophenone), 1- (2-hydroxy-4-methoxyphenyl) -1-propanone (2'-hydroxy-4'-methoxypropiophenone), 1- (2- Hydroxy-4-methoxyphenyl) -1-butanone, 1- (2-hydroxy-4-methoxyphenyl) -1-pentanone, 1- (2-hydroxy-4-methoxyphenyl) -1-hexanone, 1- (2 -Hydroxy-4-methoxyphenyl) -1-heptanone, 1- (2-hydroxy-4-methoxyphenyl) -1-octanone, 1- (2-hydroxy-4-methoxyphenyl) -1-nonanone, 1- ( 2-hydroxy-4-methoxyphenyl) -1-decanone, 1- (2-hydroxy-4-methoxyphenyl) -1-undecanone, 1- (2-hydroxy-4-methoxyphenyl) -1-dodecanone, 1- (2-hydroxy-4-methoxyphenyl) -1-tetradecanone, 1- (2-hydroxy-4-methoxyphenyl) ) -1-Hexadecanone, 1- (2-hydroxy-4-methoxyphenyl) -1-octadecanone, 1- (4-hydroxy-2-methoxyphenyl) -ethanone (4′-hydroxy-2′-methoxyacetophenone), 1- (4-hydroxy-2-methoxyphenyl) -1-propanone (4'-hydroxy-2'-methoxypropiophenone), 1- (2,4-dimethoxyphenyl) -ethanone (2 ', 4'- Dimethoxyacetophenone), 1- (2,4-dimethoxyphenyl) -1-propanone (2 ′, 4′-dimethoxypropiophenone), lactone derivatives (1,6-dioxaspiro [4.4] nonane-2,7-dione, 1,6-dioxaspiro [4.5] decane-2,7-dione, 4-tridecanolide, 4-dodecano 4-undecanolide, 4-decanolide, 4-nonanolide, 4-octanolide, 4-heptanolide, 5-dodecanolide, 5-undecanolide, 5-decanolide, 5-nonanolide, 5-octanolide, 2-undecen-4-olide, 2-decene-4-olide, 2-nonene-4-olide, 2-heptene-4-olide, 2-undecen-5-olide, 2-decene-5-olide, 2-nonene-5-olide, 2- Octene-5-olide, 4-methyl-4-dodecanolide, 4-methyl-4-undecanolide, 4-methyl-4-decanolide, 4-methyl-4-nonanolide, 4-methyl-4-heptanolide, 5-methyl- 5-dodecanolide, 5-methyl-5-undecanolide, 5-methyl-5-decanolide, 5-methyl-5-nonanolide, 5-methyl-5-octanolide, 2-methoxycarbonyl-4-dodecanolide, 2-methoxycarbonyl- 4-undecanolide, 2-methoxycarbonyl-4-decanolide, 2-methoxycarbonyl-4-nona Lido, 2-methoxycarbonyl-4-heptanolide, 2-methoxycarbonyl-5-undecanolide, 2-methoxycarbonyl-5-decanolide, 2-methoxycarbonyl-5-nonanolide, 2-methoxycarbonyl-5-octanolide, 2-allyl -4-undecanolide, 2-allyl-5-decanolide, 2-allyl-4-nonanolide, 2-pentyl-4-undecanolide, 2-pentyl-4-nonanolide, 2-methyl-4-undecanolide, 2-methyl-4 -Nonanolide, 2- (4-hydroxybutyl) -4-undecanolide, 2- (4-hydroxybutyl) -4-nonanolide, 2- (4-hydroxybutyl) -5-decanolide, 5-propyloxy-4-pentanolide , 5-allyloxy-4-pentanolide, 5- (2-hydroxyethoxy) -4-pentanolide, 8-hydroxy-4-octanolide, 6-propyloxy-5-hexanolide, 6-allyloxy-5-hexanolide, 6- ( 2-hydroxye Toxi) -5-hexanolide, 9-hydroxy-5-nonanolide, etc.), ethinomycin, iriflorental, iriparidal, 2'-8-C-glucosyl-7-methylaloesol coumaroyl ester, 2'-8-C -Glucosyl-7-methyl aloesol cinnamoyl ester, chloropyramine, anise extract, aloe extract, itadori (tiger cane root) extract, seaweed extract, shrimp extract, katsumeshi (Keiko) extract, ogi (yellow tuna) extract, yellow eagle extract, Red-crowned cucumber (Calcon) extract, Onamomi (Temple) extract, Oni Yagara (Tempa) extract, Oyster extract, Ginseng extract, Uyaku extract, Pumpkin extract, Gama (Yellow yellow) extract, Kansui extract, Kinshuhiki (Sentsukakusa) ) Extract, black moji extract, black spider extract, sisal ) Extract, Saximarum knuckle extract, Cinnamon kaffle extract, Cinnamon ginseng (wei Sensen) extract, Oshima cherry extract, Oyama cherry extract, Bean cherry extract, Takane cherry extract, Kohigan extract, Sato cherry extract, Zion extract Extract, ginseng extract, potato beetle extract, diamondfish extract, camellia extract, toshishi extract, bean pod extract, pear extract, sagebrush extract, yarrow extract, dill extract, beetle extract, beetle extract Extract, human camellia (stone persimmon) extract, Higama (koi) extract, peony extract, floral blanka extract, hamula extract, sagebrush extract, convolvulus extract, Sandalwood extract, Ganoderma lucidum extract, Japanese mackerel extract (Mascus herb) extract, Chinese willow extract, Japanese red willow extract, Japanese willow extract, Japanese black willow extract, Japanese willow extract, Japanese willow extract, Japanese yellow willow extract, Japanese willow extract, Japanese willow extract, Japanese willow extract Timber king willow extract, fox willow extract, dronox extract, bayberry (plum husk) extract, agave mid-autumn, Aono Agave extract, Fukurin Ryu
Turan extract, Mitsumata extract, Aonori extract, Usba aonori extract, Sugiaonori extract, Hiiraaoori extract, Bowuaonori extract, Hosoeda aonori extract, Kombu extract, Macombu extract, Resilib extract, Hosomome comb extract, Mitsuishi kombu extract, Wakame extract, Hirome extract Extracts Giraffe rhinoceros extract, juniper ginger rhinoceros extract, tsunomata extract, ibottsu no mata extract, malvatsu nomata extract, hirakotojieki , Sugi nori extract, Shikinori extract, Kainori extract, Yakuzusa extract, Urabo shiyahaz extract, Umiuchiwa extract, Ishimozuku extract, Misjikonbu extract, Atsuba misjibu extract, Isomok extract, Nagashimamok extract, Shimomoku extract, Nemosamo extract, Nametamo extract Tatsukuri Extract, Yatsuma Tamoku Extract, Umitorano Extract, Oba Moku Extract, Fusis Mimoku Extract, Haha Moku Extract, Yoremok Extract, Sawtooth Moku Extract, Agaric Sorghum Extract, Mukadenori Extract, Nuraxa Extract, Cronouraxa Extract, Oomkadenori Extract, Oomatsuri Extract Extract, Sponge Extract, Fushitsunagi Extract, Himefutsutsugi Extract, Hirohafutsutsugi Extract, Kurosozo Extract, Co Sozoekisu, Hanesozoekisu, Sozonohanaekisu, brush Saki sawtooth Hiba extract, Thira extract, duck over Tede bruises franc extract, Hamaikaekisu, port Leo Verde extract, Nabo Negro extract, and the like.

(4) Moisturizer Ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol, polypropylene glycol, 1 , 3-Butylene glycol, pentyl glycol, glycerin, erythritol, pentaerythritol, dipentaerythritol, threitol, arabitol, xylitol, ribitol, galactitol, sorbitol, mannitol, lactitol, maltitol, scylitol, laminitol, valienamine, validamine, validatol Polyhydric alcohols such as Beer rubber, benzoin rubber, danmar rubber, guaiac oil, Irish moss, Karaya rubber, tragacanth rubber, carob rubber, quinseed, agar, casein, glucose, galactose, mannose, xylose, fructose, maltose, isomaltose, cellobiose, gentiobiose, trehalose, cordobiose, lamina Libiose, nigerose, cellobiose, sambubiose, neohesperidose, apiose, hammamellose, streptose, hydroxystreptose, dihydrostreptose, 2-methylerythrose or derivatives thereof, 2-methylerythronolactone, mycarose, cladinose, accentose , Arcanose, Oribomai course, Chromose, Ebami course, Vinelose, Nogarose, Billenose, Saccharide such as biose, moenuronic acid, galosamine, ciblosamine, N-acylcansamine, vancosamine, evanitrose, rubranitrose, tetronitrose, pyralose, α-octose, trioxacalcinose, aldogalose, blastogynosine, trehalose or derivatives thereof , D-mannosamine and derivatives thereof, primeverose or derivatives thereof, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or chitosan, hydroxyalkyl (C2 to C4) to which alkylene (C2 to C4) oxide such as ethylene oxide is added ) Chitin or chitosan, low molecular chitin or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or salt thereof, hyaluronic acid or Its salt, chondroitin sulfate or its salt, 1,3-β glucan, heparin, ethyl cellulose, methyl cellulose, carboxymethyl cellulose, carboxyethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, hydroxypropyl methylcellulose, polyvinyl Water-soluble, such as alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyalkylene oxide such as polyethylene oxide and polypropylene oxide or cross-linked polymers thereof, carboxyvinyl polymer, polyethyleneimine, dermatan sulfate, keratan sulfate Polymers, glycerin fatty acid pyrrolidone carboxylic acid ester Tells, glycerin fatty acid acetylamino acid esters, pyrrolidone carboxylic acid or salt thereof, polyaspartic acid or salt thereof, polyglutamic acid or salt thereof, polylysine or salt thereof, sodium lactate, hydantoin and derivatives thereof, Np-vinylbenzyl-D- Cellobionamide, Np-vinylbenzyl-D-lactone amide, Np-vinylbenzyl-D-maltonamide, Np-vinylbenzyl-D-gluconamide, glucosyloxyethyl methacrylate, galactosyloxypropyl acrylate, mannosyloxyethyl methacrylate, glutamyl Lysine, glutaurine, 1,2,4-butanetriol, caran-3,4-diol, azoxaponin (3-o- [β-D-glucopyranosyl-β-D-glucuronopyranosyl] -sophoradiol, 3- o- [β-D-glucopyranosyl-3-D-glucuronopyranosyl -Soyasapogenol B, 3-o- [β-D-glucopyranosyl-β-D-glucuronopyranosyl] -azuxapogenol, 3-o- [β-D-glucopyranosyl] -28-o- [Β-D-glucopyranosyl-β-D-glucopyranosyl] -dipsogenic acid, 3-o- [α-L-rhamnopyranosyl-β-D-glucopyranosyl-β-D-glucuronopyranosyl] -soya sapogenol B 3-o- [β-D-glucopyranosyl-β-D-glucuronopyranosyl] -29-o- [β-D-glucopyranosyl-β-D-glucopyranosyl] -azuxapogenol, etc.), Aoki ( Aoki) extract, Aogi extract, Kenashia Ogiri extract, Red clover extract, Red clover extract, Akikara pine extract, Aguahe (Amanita coconut) extract, Maruba morning glory extract, Asagao extract, Athira (Shokuyo kanna) Extract, oilseed rape extract, amachazulue Kiss, Amana extract, Ayuyu extract, Hagateto extract, Homogatetope extract, Senninoku extract, Sugimori gateto extract, Hosoa Ogretou extract, Aogateto extract, Haribiyu extract, Aozulan extract, Amaranthus hippochondriax extract , Aristolomeria extract, Arcana extract, Algarrobo extract, Aloe vera extract, Rabbit extract, Yew (first place) extract, Strawberry extract, Carob bean extract, Inazuna (Taylexi) extract, Rice extract, Dog mint extract, sardine tobacco (Iwabuchi) extract, iwahiba extract, sardine pine (roll mushroom) extract, wheat (chibusanoki) extract, duckweed (float) extract, euglena extract, euglena extract ) Extract, Enokitake mushroom extract, eringi extract, pre-lotus eringi extract, Ogata Houken extract, Oogurma (Civil fragrance) extract, Steller's beetle (cereal essence) extract, Oka extract, Okazeri (serpentine) extract, Okra Extract, Onidokoro Extract, Tokoro Extract, Nagadokoro (Hikai) Extract, Ononis Extract, Yuuko Extract, Oyster Extract, Ginseng Extract, Ganohydrangea Extract, Cascara Sagrada Extract, Gypsophila Extract, Panax Ginseng Extract, Caniva Extract, Carnation Extract, Gerbera extract, camouflage (camo duck) extract, color extract, oat extract, karin extract, Kawara Psycho extract, kawajisha extract, kawaranadeshiko (stone bamboo) extract, Ezokawaranadeko (buckwheat, buckwheat) Kiss, Kantara extract, Kikutaniku extract, quinoa extract, cabbage extract, kiwi extract, cucumber extract, gyory extract , Kuzu (Kudzroot) extract, Ginseng extract Cosmos extract, coconut krill extract, rice oil extract, konjac extract, saffron (banban flower, west safflower) extract, sapodilla extract, sangre degrad (croton) extract, sanchinin carrot (37 ginseng) extract, shea (carite) extract , Cyanoki extract, shiitake extract (shiitake) extract, shiitake Di extract, Hinshimeji extract, Shakashimeji extract, Hatake shimeji extract, Oshiroi shimeji extract, Buna shimeji extract, Honjimeshi extract, Shirotamogitake extract, Shimokurene extract, Saishin extract, Cactus extract, Janohige (bara winter) extract, Shukukonka miso extract, Zouzan hydrangea (Tsuneyama) extract, white-faced butterfly extract, white-leafed adzuki (chicken bone grass) extract, ginkgo biloba (Mizuka, Mizuka flower, Shencho flower) extract, watermelon (Western phoenix) extract, Suzu-Psycho (Xucho cocoon) extract, subhihiyu (horse tooth soap, Horse tooth extract) extract, boiled extract, cherry blossom extract, Japanese apricot extract, Japanese apricot extract, Okinawa aquatic extract, Japanese apricot extract, an antelope extract, a Japanese apricot extract, a Japanese apricot extract (Bush Shukuboku) extract, mallow extract, celery extract, senshinren (Daishinren) extract, Japanese radish (radish) extract, Takasaburo (Boku lotus) extract, Tachidokoro (hikai) extract, dahlia (tenjiku button) extract, tarwi extract Sengokushi extract, Sojutsu extract, Chankapiedra extract, Tulip extract, Chorogi extract, Tsukuritake (mushroom) extract, Camellia extract, Clover (lacquered licorice) extract, Tonabena (river cut) extract, Corn extract, Corn hair (Southern eyelash) extract, Toxa (wood band) extract, Torico (crust) extract, Turkish yellow pepper extract, Solid bean extract, Vertical bean extract (Sword bean) extract, Jujube (Daisen) extract, Navena (interrupted) extract, Nameko extract, Nambang Karamushi (Hemp) Extract, Niosum Ville Extract, Nutzuku extract, Nemum extract, Nebu extract, Nebi extract, Nemurioki extract, Digokubana (community) extract, Nogateto extract, Hylindough extract, Hauchiwa extract, Hauchi bean extract, Papaya extract, Pahalobo extract, Balata rubber extract, Haratake extract, Haratake extract, White oharatake extract , Usukimorinokasa extract, Haran extract, Pariurus (Amanita spp.) Extract, Balsamina (Spirea, bitter gourd) extract, Harindou extract, Handaikai (Yutakakai) extract, Hygurmadori extract, Beet extract, Hiba extract, Sunflower extract, Pepper extract, Himeuzu (Tenpo) extract, Japanese pine bamboo (Kawariharatake, Hiromatsutake) extract, Fuyumushinakusatake (Cycium Cordyceps) extract, Brazilian licorice extract, hazel Extract, loofah extract, diatomaceous earth extract, nettle extract (sparkling) extract, broomweed extract, elder extract, nendo extract, scallop extract, ground scallop extract, spinach (saccharidum, acute kid, pelagic grass) extract, falcon extract Nokirinso (Keiten 37) extract, Jojoba extract, Borage (Lurichisha) extract, Bordeaux extract, Hononiku (meat juju, Taigei) extract, Honsekkok (iron skin stone, Sparrow mountain stone) extract, Maca extract, Macadamia nut extract, Margaret extract, Tamanosen Hallen extract, Kyukon Kinlenka extract, Matatabi (wooden cocoon) extract, Matsukasa extract, Matsuhodo (sardine) extract, Matico (cordon sillo) extract, quince extract, malein (browed mud squid) extract , Manzanya (Andesca Extract) ) Extract, ilex extract, cornflower extract, yacon extract, coconut extract, yab tobacco (crane gourd, tennasei) extract, malonie extract, mokka extract, lily extract, ligan extract, lime extract, rye extract, jackfruit extract, shallot (Palm-white) extract, apple extract, gentian extract, litchi (wedge, toothpick nucleus) extract, forsythia extract, yokuinin extract, minisasaniki extract, chlorella vulgaris extract, chlorella pyrenoid extract, chlorella ellipsoidia ex , Macrocystis pirifera extract, Yuikiri extract, Tosakanori extract, Cyprinus extract, Amakusaori extract, Aoumidro extract, Kawanoori extract, Marimo extract, Motsukihitoe extract, Ezoyahaz extract, Habanori extract, Habanori extract, Watamo extract, Aname extract, Sujime extract Extract, Antokume extract, Tsuruarame extract, Kuroshiome extract, Nekoshikonbu extract, Ainuwakame extract, Chigaiso extract, Ezoi Shige extract, Yabanemoku extract, Trumpet extract, Uganomok extract, Joromoku extract, Hiemonoku extract, Tamanashimok extract, Honda wall extract, Sugi moku extract Bovine Kenori Extract, Susabiori Extract, Akebono Mozuku Extract, Cypridina Extract, Fusanori Extract, Ho Banaminohana extract, Hanafnori extract, Itohnori extract, Kaginori extract, Mirin extract, Hosobamyrin extract, Kikutosaka extract, Ezonameshi extract, Ibaranori extract, Kagyi baranori extract, Saidaibara extract, Tatyibara extract, Ogonori extract, Tsurusilamo extract, Honey beetle extract, red clover extract, red ginseng extract, natto fungus culture metabolite, natto extract, loofah water, birch (white birch) or red pine sap, etc.

(5) Cell Activator / Metabolic Activator Vitamin A Group: Retinol or its salts and derivatives thereof (retinyl unsaturated fatty acid esters such as retinyl linoleate, retinyl linolenate, retinyl oleate, retinyl arachidonic acid, etc.), Retinal or a salt thereof and derivatives thereof, dehydroretinal or a salt thereof and derivatives thereof, retinoic acid or a salt thereof and derivatives thereof, retinoic acid analog (4-[[[8- (3,5-dimethylphenyl)- 2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (3-methylphenyl) -2-naphthalenyl) carbonyl] amino] benzoic acid, 4-[[[8- (4-methylphenyl)- 2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[[8- (2-methylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4- [[8- (3,4-Dimethylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2,4-dimethylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid 4-[[[8- (2-Isopropylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-ethylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid 4-[[[8- (2-Fluorophenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-methoxyphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid 4-[[((8-benzyl-2-naphthalenyl) carbonyl] amino] benzoic acid, 4-[(E) -2- (8-phenyl-2-naphthalenyl) propenyl] benzoic acid), retinoic acid derivatives (4 -Hydroxyphenylretinamide), retinoid analogues (4-[[(5,6 -Dihydro-5,5-dimethyl-8-ethyl-2-naphthalenyl) amino] carbonyl] benzoic acid, 4-[[((5,6-dihydro-5,5,8-trimethyl-2-naphthalenyl) amino] carbonyl ] Benzoic acid, 4-[[((5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) amino] carbonyl] benzoic acid, 4-[[((5,6-dihydro-5,5 -Dimethyl-8-ethyl-2-naphthalenyl) carbonyl] amino] benzoic acid, 4-[[((5,6-dihydro-5,5,8-trimethyl-2-naphthalenyl) -carbonyl] amino] benzoic acid, 4 -(E)-[2- (5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) -1-propenyl] benzoic acid, 4-[[((5,6-dihydro-5, 5-dimethyl-8-phenyl-2-naphthalenyl) oxy] carbonyl] benzoic acid, 4-[[((5,6-dihydro-5,5-dimethyl-8-phenyl-2- (naphthalenyl) carbonyl] amino) benzoic acid Acid, 4-[[( 5,6-dihydro-5,5-dimethyl-8-phenyl-2- (naphthalenyl) carbonyl] oxy] benzoic acid, 4-[[5,6-dihydro-5,5-dimethyl-8- (2-fluoro) Phenyl) -naphthalenyl] carbonyl] amino] benzoic acid, 4-[[((5,6-dihydro-5,5,6-trimethyl) -8-phenyl-2- (naphthalenyl) carbonyl] amino] benzoic acid, 4- [[((5,6-dihydro-5,5,7-trimethyl-8-phenyl-2-naphthalenyl) carbonyl] benzoic acid, 4-[[((E)-(5,6-dihydro-5,5-dimethyl -8-phenyl) -2-naphthalenyl] vinyl] benzoic acid, 4-[[[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] sulfamyl] benzoic acid, 4 -[[[((5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl] sulfamyl) carbonyl] benzoic acid, 4-[[((5,6-dihydro-5,5-dimethyl-8 -Phenyl) -2-naphth Talenyl] ethyl] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] thiocarbonyl] amino] benzoic acid, 4-[[[((5, 6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] methyl] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2 -Naphthalenyl] methyl] oxy] benzoic acid, 4-[[[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthenyl] oxy] methyl] benzoic acid, 4-[[[( 5,6-dihydro-5,5-dimethyl-8- (2,4-dimethylphenyl)]-2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[((5,6-dihydro-5,5 -Dimethyl-8- (4-methylphenyl)]-2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] Ethyl) benzoic acid, 4-[[[[ (5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] sulfamyl] methyl] benzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] methyl] amino] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] amino] thiocarbonyl] benzoic acid, 4- [ [[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] methyl] sulfamyl] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8 -Phenyl-2-naphthalenyl] amino] methyl] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] amino] -2-hydroxybenzoic acid 4-[[[((5,6-Dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] amino] -2-nitrobenzoic acid, 4-[[[((5,6- Dihydro-5,5-dimethyl-8 -Phenyl) -2-naphthalenyl] carbonyl] amino] -2-fluorobenzoic acid, 4-[[[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl] carbonyl] amino]- 2-methoxybenzoic acid, 4-[[[[(5,6-dihydro-5,5-dimethyl-8- (2-naphthalene)]-2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[(5 , 6-Dihydro-8-phenyl-2-naphthalenyl) carbonyl] aminobenzoic acid, 4-[[((5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) carbonyl] amino] -3 4-fluorobenzoic acid, 4-[[((5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) carbonyl] amino] -3-methylbenzoic acid, 4-[[(5,8, 10,10a-tetrahydro-10,10-dimethyl-9-phenyl-2-anthracenyl) carbonyl] amino] benzoic acid, 4-[[((1,1-dimethyl-3-phenyl-1H1-inden-5-yl) Mino] carbonyl] benzoic acid, 4-[(1,1-dimethyl-3-phenyl-1H-inden-5-yl-oxymethyl) benzoic acid, 4- [2- (1,1-dimethyl-3-phenyl) -1H-Inden-5-yl) vinyl] benzoic acid, 4-[(1,1-dimethyl-3-phenyl-1H-indene-5-carbonyl) amino] benzoic acid), carotene or its salts and their derivatives (Carotenoids such as α-carotene, β-carotene, γ-carotene, lycopene, cryptoxanthine, lutein, zeaxanthin, isosexanthine, rhodoxanthine, capsanthin, crocetin), lycopene or a salt thereof and derivatives thereof, vitamin B group: thiamine or a salt thereof As well as their derivatives (thiamine hydrochloride, thiamine disulfide, bisbenchamine, bisivethiamine, thiamine monophosphate disulfide, benfotiamine, Cotyamine, octothiamine, dicetiamine, fursultiamine, prosultiamine, astaxanthin thiamine phosphate diester, etc.), thiamine sulfate, riboflavin or salts thereof and derivatives thereof (flavin adenine dinucleotide, flavin mononucleotide, riboflavin phosphate diester, 1-β-D-ribofuranosyl nicotinamide pyrophosphate diester, 1-β-D-ribofuranosyl nicotinic acid, etc.), pyridoxine or a salt thereof and derivatives thereof (3,4-dipalmitic acid pyridoxine, 3,4 -Pyridoxine dicaprylate, pyridoxine sulfate diester, etc.), pyridoxal or a salt thereof and derivatives thereof, pyridoxamine or a salt thereof and derivatives thereof, cyanocobalamin or a salt thereof and derivatives thereof, cobalamin (methylcobalami) , Adenosylcobalamin, hydroxocobalamin, aquacobalamin, etc.), folic acid or salts thereof and derivatives thereof, nicotinic acid or salts thereof and derivatives thereof, pantothenic acid or salts thereof and derivatives thereof, biotin or salts thereof and derivatives thereof , Choline or a salt thereof and derivatives thereof, inositol or a salt thereof and derivatives thereof, vitamin C group: ascorbic acid or a salt thereof and derivatives thereof, vitamin D group: ergocalciferol or a salt thereof and derivatives thereof, cholecalci Ferrol and its salts and their derivatives (1α-hydroxy-22-[(1-hydroxy-1-methyl) -2-cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanol Calciferol, [1R, 4R] -1α-hydroxy-22-[(1-hydroxy-1-methyl) -2-cyclope Ten-4-yl-oxy] -23,24,25,26,27-pentanorcorecalciferol, [1R, 4S] -1α-hydroxy-22-[(1-hydroxy-1-methyl) -2- Cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanorcorecalciferol, [1S, 4R] -1α-hydroxy-22-[(1-hydroxy-1-methyl) -2- Cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanorcorecalciferol, [1S, 4S] -1α-hydroxy-22-[(1-hydroxy-1-methyl) -2- Cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanorolecalciferol and the like, dihydrotaxosterol or a salt thereof and derivatives thereof, vitamin E group: tocopherol or a salt thereof and derivatives thereof, Tocotrienol or a salt thereof and derivatives thereof, ubiquinone or a salt thereof and derivatives thereof, vitamin K group: phytonadione or Salts thereof, derivatives thereof, menaquinone or salts thereof and derivatives thereof, menadione or salts thereof and derivatives thereof, menadiol or salts thereof and derivatives thereof, vitamin F group: linoleic acid or salts thereof and derivatives thereof, linolenic acid Or salts thereof and derivatives thereof, arachidonic acid or salts thereof and derivatives thereof, carnitine or salts thereof and derivatives thereof, ferulic acid or salts thereof and derivatives thereof, γ-oryzanol or salts thereof and derivatives thereof, orot Acids or salts thereof and derivatives thereof, vitamin P group: rutin or salts thereof and derivatives thereof, eriocitrin or salts thereof and derivatives thereof, hesperidin or salts thereof and derivatives thereof, vitamin L group: anthranilic acid or salts thereof As well as those Conductor, adenylthiomethylpentose or salt thereof and derivatives thereof, vitamin U group: methylmethionine sulfonium chloride or derivative thereof, valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine , Serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine, arginine, ornithine, histidine or a derivative thereof (N-octyloxycarbonyl-β-alanyl-L-histidine, N-dodecyloxycarbonyl -β-alanyl-L-histidine, N- (12-amino-1-oxododecyl) -L-histidine, N-2-ethylhexyloxycarbonyl-β-alanyl-L-histidine hydrochloride, N-hexadecylo Cycarbonyl-β-alanyl-L-histidine, N-octylaminocarbonyl-β-alanyl-L-histidine, N-dodecylaminocarbonyl-β-alanyl-L-histidine, N-dodecylsulfonyl-β-alanyl-L- Amino acids such as histidine, N-dodecylamino-oxalyl-β-alanyl-L-histidine, etc.) and their amino acid derivatives such as sulfate, phosphate, nitrate, citrate, or pyrrolidone carboxylic acid, glycol Α-hydroxy acids such as acid, citric acid, malic acid, tartaric acid, lactic acid, succinic acid, 2-hydroxycarboxylic acids (methyl lactic acid, 2-hydroxybutanoic acid, 2-hydroxypentanoic acid, 2-hydroxyhexanoic acid, 2-hydroxy Hydroxyheptanoic acid, 2-hydroxyoctanoic acid, 2-hydroxynonanoic acid, 2-hydroxydecanoic acid, 2-hydroxyundecanoic acid, α-hydroxylaurin Acid, α-hydroxymyristic acid, α-hydroxypalmitic acid, α-hydroxystearic acid, α-hydroxyarachidonic acid, cerebronic acid, α-hydroxynervonic acid, mandelic acid, benzylic acid, phenyllactic acid, atrolactic acid, 2- ( 4'-hydroxyphenyl) -2-hydroxyethanoic acid, 2- (4'-chlorophenyl) -2-hydroxyethanoic acid, 2- (3'-hydroxy-4'-methoxyphenyl) -2-hydroxyethanoic acid, 2 -(4'-hydroxy-3'-methoxyphenyl) -2-hydroxyethanoic acid, 3- (2'-hydroxyphenyl) -2-hydroxypropanoic acid, 3- (4'-hydroxyphenyl) -2-hydroxypropane Acid, 2- (3 ', 4'-
Dihydroxyphenyl) -2-hydroxyethanoic acid, glyceric acid, erythronic acid, ribbon acid, arabinonic acid, xylonic acid, lyxonic acid, arolic acid, altronic acid, gluconic acid, mannonic acid, gulonic acid, idonic acid, galactonic acid, talon Acid, glucoheptonic acid, galactoheptonic acid, tartronic acid, mucinic acid, etc.), polyhydroxycarboxylic acid or hydroxypolycarboxylic acid (gluconolactone, galactonolactone, glucuronolactone, galacturonolactone, gulonolactone, ribonolactone, sugar lactone) , Pantoyl lactone, glucoheptonolactone, mannonolactone, galactoheptonolactone, etc.), 2-keto acids (glyoxylic acid, methyl 2-ketoethanoate, benzoylformic acid, methyl benzoylformate, ethyl benzoylformate, pheny (Rupyruvic acid, methyl phenylpyruvate, ethyl phenylpyruvate, 2-ketobutanoic acid, 2-ketopentanoic acid, 2-ketohexanoic acid, 2-ketoheptanoic acid, 2-ketooctanoic acid, 2-ketododecanoic acid, methyl 2-ketooctanoate, etc.) , Quinic acid, isocitric acid, tropic acid, tretocanic acid, 3-chlorolactic acid, cerebronic acid, citramalic acid, agaricinic acid, alloyic acid, pantoic acid, lactobionic acid, hexulosonic acid, photosensitizer 301, hinokitiol, pantothenic acid or its Derivatives, allantoin, pentadecanoic acid glycerides, linolenic acid or derivatives thereof, eicosapentaenoic acid or derivatives thereof, docosahexaenoic acid or derivatives thereof, estradiol, ethenylestradiol, antialol or glycosides thereof, rioniresinol or glycosides thereof, rhodede Ndrol or its glycoside, platifironol or its glycoside, lactone compound (D-glucurono-6,3-lactone, α-D-glucoheptonic-γ-lactone, δ-glucuronolactone, α, β -Glucooctonic-γ-lactone, L-glonic-γ-lactone, γ-D-galactonolactone, D-saccharide-1,4-lactone, D-saccharide-3,6-lactone, D-ribonic-γ -Lactone, α-butyrolactone, γ-butyrolactone, α-octanoic lactone, γ-octanoic lactone, nonanoic lactone, γ-valerolactone, D-manninoic-δ-lactone, D-xyloic-δ-lactone, D-arabinoic-δ-lactone, stearoyl-δ-gluconolactone, DL-pantolactone, palmitoyl-DL-pantolactone, etc.), 3-hydroxy-3,4-dicarboxy-1,4-butanolide or derivatives thereof , 6-benzylaminopurine or derivatives thereof, 1,4-diazadicyclooctane, 2,5-dimethylfuran, 2-methylfuran, 2,5-diphenylfuran, 1,3-diphenylisobenzofuran, rutin, tektrigenin 7 -Xylosyl glucoside, captopril, alacepril, lisinopril, enalapril, delapril, benazepril, cilazapril, imidapril, quinapril, trandelapril, perindopril, temocapril, losartan, endothelin, galactomannan saccharide polymer, mucin, trimethylglycan, proteo extract Lactic acid bacteria culture extract, lactic acid bacteria fermented milk extract, bifidobacteria extract, bifidobacteria culture extract, bifidobacteria fermented milk extract, placenta extract, ganoderma extract, spleen extract, thymus extract, yeast extract, Mother culture extract, yeast fermentation extract, filamentous fungus extract, filamentous fungus culture extract, basidiomycete extract, basidiomycete culture extract, bacterial cell disruption extract, bacterial culture extract, cultured human dermal cell disruption extract, Ground yellow) extract, fennel (mushroom) extract, sorghum (barley gourd) extract, barley (barley) extract, oakuri higotai (Yeoju leakage, indigo piercing) extract, komeba hypericum extract, hypericum perforatum extract, holland jelly extract , Dutch Honey Bee Extract, Silkworm Extract, Roman Chamomile Extract, Garcinia Extract, Kawarani Ginseng (Blue Agate) Extract, Kakiran Extract, Quillaja Extract, Kinlan Extract, Ginlan Extract, Calendula Extract, Sakakanelan Extract, Sasabaginran Extract, Sawagurumi (Mountain) (Walnut) extract, shimo Pepper extract, Shajin extract, plum extract, walnut extract, cedar extract, pineapple extract, Chinese cabbage extract, Japanese cypress extract, beech extract, physalis extract, maitake (maiko) extract, misohagi ( Chikuma) extract, Mukuge (Kiso) extract, Mukuroji (prolonged skin) extract, coconut extract, Eucalyptus extract, Yukinoshita (tiger ear grass) extract, Suabisimus extract, Lettuce (Chisha) extract, Aloe extract, Ogon Extract, Tonka Bean Extract, Gentiana Extract, Burdock Extract, Shikon Extract, Carrot Extract, Clam Squirrel Extract, Hop Extract, Yokuinin Extract, Odorikosou Extract, Assembly Extract, Toki Extract, Tokisenka Extract, Achacha Extract, Hypericum Extract, Cucumber Extract, Tachija Cranberry extract, rosemary extract, parsley extract, sandadagusa extract, fukurin amiji extract, guts-comb extract, oyster-comb extract, oni-konbu extract, gohei-comb extract, naga-comb extract, pea-comb extract, prickly-comb extract, rattle extract Rattle extract, Benimozuku extract, Hosobenimozuku extract, Kagekinori extract, Ezotosaka extract, Shiramo extract, birch extract, salicylic acid or salts thereof and derivatives thereof (salicylic acid glucoside, salicylic acid fatty acid ester, salicylic acid alcohol ether, salicylic acid amides, etc.) , Salicyl alcohol or a salt thereof and derivatives thereof, apigenin, ament flavone, salamander extract, udo extract, shishido extract, gasho extract, potato Extract, bovine taxis extract, cuckoo thistle extract, scallion (sheep-root) extract, gymnema sylvesta extract, carrion extract, ginkgo biloba extract, konronka extract, sabrunryo extract, jasmine (matsurika) extract, hollyhock extract, gypsophila extract , Arabidopsis extract, Lily of the valley extract, Souzo extract, Deco extract, Tochu extract, Nagii Kada (Butcher bloom) extract, Teppo cucumber extract, Tokiwa mansaku extract, Nankin goby extract, Niwa urushi extract, Nadeshiko extract, Michiyanagi extract, Japanese willow extract Hemp) extract, yellow willow extract, weeping willow extract, magnolia extract, yah-so-so extract, wakame wisteria extract, leopard cauli extract, ajijigusae Kiss, shellfish extract (cockle extract, green mussel extract, oyster extract, European oyster extract, scallop extract, clam extract, clam extract, bakagai extract, ishi mussel extract, red mussel extract, abalone extract, turban shell extract, bi-extract, etc.).

(6) Antioxidants Ascorbic acid or its salts and their derivatives (magnesium phosphate-L-ascorbate, ascorbyl palmitate, ascorbyl dipalmitate, ascorbyl hydroxyprophosphate, 5-o-α-D -Glucopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate sodium salt, L-ascorbic acid phosphate potassium salt, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate calcium salt, L- Ascorbic acid phosphate aluminum salt, L-ascorbic acid sodium salt, L-ascorbic acid potassium salt, L-ascorbic acid sulfate magnesium salt, L-ascorbic acid sulfate calcium salt, L-ascorbic acid sulfate Aluminum salt, L- Scorbic acid sodium salt, L-ascorbic acid potassium salt, L-ascorbic acid magnesium salt, L-ascorbic acid calcium salt, L-ascorbic acid aluminum salt, 6-o-α-D-galactopyranosyl-L-ascorbic acid 2-o-β-D-galactopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate sodium salt, L-ascorbic acid sulfate sodium salt, 6- o-acyl ascorbic acid phosphate sodium salt, 6-o-acyl ascorbic acid phosphate ammonium salt, 6-o-acyl ascorbic acid phosphate isopropanolamine salt, 3-o-isopropyl-L-ascorbic acid, 6 -o-alkylascorbic acid phosphate potassium salt, 6-o-alkylascorbic acid phosphate calcium salt, 6-o- Rualkylascorbic acid phosphate barium salt, 6-o-alkylascorbic acid phosphate ammonium salt, 6-o-alkylascorbic acid phosphate monoethanolamine salt, 6-o-alkylascorbic acid phosphate diethanolamine salt, 6-o-alkylascorbic acid phosphate triethanolamine salt, 6-o-alkylascorbic acid phosphate monoisopropanolamine salt, 6-o-alkylascorbic acid phosphate diisopropanolamine salt, 6-o-alkyl Ascorbic acid phosphate triisopropanolamine salt, 3-o-glycosyl-L-ascorbic acid, 6-o-β-D-galactopyranosyl-L-ascorbic acid, ascorbic acid phosphate cholesterol ester, palmitic acid L- Ascorbyl, L-ascorbyl isopalmitate, L-ascorbyl dipalmitate, L-ascorbyl diisopalmitate, L-ascorbyl stearate, L-ascorbyl isostearate, L-ascorbyl distearate, L-ascorbyl diisostearate, L-ascorbyl myristic acid, L-ascorbyl myristate, L-isomyristic acid L- Ascorbyl, dimyristic acid L-ascorbyl, diisomyristic acid L-ascorbyl, 2-ethylhexanoic acid L-ascorbyl, di-2-ethylhexanoic acid L-ascorbyl, oleic acid L-ascorbic acid, 2-o-α-D -Glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α-D-maltotriosyl-L-ascorbic acid, 3-o-α-D-glucosyl- L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α-D-maltotriosyl-L-ascorbic acid, L-ascorbic acid tetraisopalmitate, L -Ascorbic acid tetralauric acid ester, L-ascorbic acid tetra-2-ethylhexanoic acid ester, L-ascorbic acid tetraoleic acid ester, 5,6-isopropylidene-L-ascorbic acid, le, L-ascorbic acid retinol ester , L-ascorbic acid-DL-tocopherol phosphate ester, L-3-o-ethylascorbic acid, L-ascorbic acid tristearate, L-ascorbic acid tripalmitate, L-ascorbic acid trioleate, L-ascorbic acid Triphosphate, 2-o-ascorbyl cinnamate, 2-o-ascorbyl ferrate, 2-o-ascorbyl caffeate, 2-o-ascorbyl synapate, 2-o- [6-palmitoyl ascorbyl] -4'- Acetoxyferrate, DL-α-tocopherol-2-L-ascorbic acid phosphate diester, inositol ascorbate Derivatives, ascorbic acid phosphoramide derivatives, ascorbic acid arbutin conjugates, ascorbyl phosphoryl cholesterol, chromanyl ascorbic acid derivatives, ascorbic acid sialic acid derivatives, etc.), stearates, tocopherols or their salts and derivatives thereof (α-tocopherol, β-tocopherol) , Γ-tocopherol, δ-tocopherol, ε-tocopherol, α-tocopheryl retinoate, aminomethylated tocopherol, hydroxymethylated tocopherol, tocopheryl phosphate ester, tocopherol acetate, tocopherol nicotinate, tocopherol succinate, tocopherol linoleate , Tocopherol orotate, DL-α-tocopheryl glucoside, DL-α-tocopheryl maltoside, DL-β-tocopheryl glucoside DL-β-tocopheryl maltoside, DL-γ-tocopheryl glucoside, DL-γ-tocopheryl maltoside, DL-δ-tocopheryl glucoside, DL-δ-tocopheryl maltoside, D-α-toco Ferryl glucoside, D-α-tocopheryl maltoside, D-β-tocopheryl glucoside, D-β-tocopheryl maltoside, D-γ-tocopheryl glucoside, D-γ-tocopheryl maltoside, D-δ- Tocopheryl glucoside, D-δ-tocopheryl maltoside, L-α-tocopheryl glucoside, L-α-tocopheryl maltoside, L-β-tocopheryl glucoside, L-β-tocopheryl maltoside, L-γ -Tocopheryl glucoside, L-γ-tocopheryl maltoside, L-δ-tocopheryl glucoside, L-δ-tocopheryl maltoside, 1- (sulfoethylamino) -3- (α-tocopheryl-6- Iroxy) propan-2-ol, 1- (carboki Cypropylamino) -3- (α-tocopheryl-6-iroxy) propan-2-ol hydrochloride, S- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] cysteine, S- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] -γ-glutamylcystenylglycine, N- [3- (α-tocopheryl-6-iroxy) -2-hydroxy Propyl] aspartic acid, N- [3- (α-tocopheryl-6-yloxy) -2-hydroxypropyl] glutamic acid, etc.), tocotrienol or a salt thereof and derivatives thereof (α-tocotrienol, β-tocotrienol, γ- Tocotrienol, δ-tocotrienol, tocotrienol acetate, tocotrienol nicotinate, tocotrienol succinate, tocotrienol linoleate, tocotrienol orotate), di Dropyridine derivatives (methyl-3-phenyl-2-propenyl 1,4-dihydro-2,6-dimethyl-4- (3-nitrophenyl) pyridine-3,5-dicarboxylate and its salts), benzochroman derivatives, nor Dihydroguaselectenic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, parahydroxyanisole, propyl gallate, sesamol, sesamolin, gossypol, maritimaine, sulfretin, xanthene-2,7-diols , Caffeoylquinic acids, propolis, carotenoids (α-carotene, β-carotene, γ-carotene, lycopene, lutein, violaxanthin, spiriloxanthin, spheroidene, astaxanthin, etc.), fluorotannin, akebi (wood) extract, Amacha (Amacha) extract, Oolongcha extract, Randabille extract, kanran extract, kumquat extract, goblet extract, geno shochu (old lady's grass) extract, sesame extract, sesame culture cell extract, sesame extract (genus ginseng) extract, rice bran extract, pomegranate extract, salamander extract, pear extract, Daio (Dai yellow) extract, Tomato extract, Nanten (Southern fruit) extract, Noazami (Daisen) extract, Neubara (Yutami) extract, Paprika extract, Pistachio extract, Biwa extract, Betel wax (Large skin, coconut) extract, Japanese bursa extract, Bokeh (Kiso) extract, Hosobaoguruma extract, Mao (mao) extract, Mimosa extract, Mebogi extract, Japanese black willow extract, Willow tree extract, Watafujitsugi extract Extract, Oto Risouekisu, witch hazel extract, clove extract, Melissa extract, EMME picolinimidate extract, white birch extract, salvia extract, rosemary extract, nandina fruit extract, ginkgo extract, green tea extract, clove extract, and the like.

(7) Active oxygen scavenger / radical scavenger Superoxide dismutase, catalase, glutathione peroxidase, bilirubin, quercetin, quercitrin, catechin, catechin derivatives, rutin or its derivatives, gallic acid or its salts and derivatives thereof, curcumin or its Salts and derivatives thereof, transferrin, ceruloplasmin, coenzyme Q, uric acid, bilirubin, metallothionein, stilbenegaloyl glycoside (3,5,4'-trihydroxystilbene 4'-o-β-D- (6 "galloyl ) Glucopyranoside, 3,5,4'-trihydroxystilbene 4'-o-β-D- (2 "galloyl) glucopyranoside), chlorogenic acid phospholipid ester, chlorogenic acid sphingosine ester and derivatives thereof, chlorogenic acid glycolipid ester , Chlorogenic acid sugar ester, black Genolic acid sterol ester, thiazole derivative or salt thereof (2- (3,4-diethoxyphenyl) -4- (3-carboxy-4-hydroxyphenyl) thiazole, 2- (3,4-diethoxyphenyl) -4 -[3-carboxy-4-hydroxy-5- (2-methyl-2-propenyl) phenyl] thiazole and 2- (3,4-diethoxyphenyl) -4- (3-carboxy-4-hydroxy-5- Methylphenyl) thiazole, 2- (3,4-diethoxyphenyl) -4- (3-carboxy-5-methoxyphenyl) thiazole,), hydroxymatilesinol, allohydroxymatilesinol, hydantoin derivative, akaminoki (log) (Wood) extract, red-crowned wrinkle (red bud) extract, red-breasted rape extract, red-brown radish extract, red radish (hydrangea) extract, hydrangea extract, abemaki extract, fig extract, ginkgo biloba Kiss, Asparagus extract, Japanese apricot extract, Vulture extract, Japanese walrus extract, Estragon extract, Enju (Apricot flower, Spike rice) extract, Oak (Apricot tree, Bamboo leaf) extract, Acacia extract, Hippopotamus extract , Birch extract, cucumber extract Extract, perilla extract, white-tailed extract, chimpanzeo extract, catamendizo extract, peonies (glaze) extract, Japanese oak extract, Japanese oak extract, crape myrtle extract, zicopi extract, white-bellied extract, white clover (clover) extract, horseradish extract, black tea extract, green tea Extract, Tsuwabuki Extract, Tencha Extract, Tendai Yaku Extract, Nani Waibara (Golden Cherry) Extract, Groundnut Extract (Peanut) Extract, Kei Extract, Nikkei Extract, Ceylon Nikkei Extract, Yab Nikkei (Kinshiki) Extract, Keishi (Keishi Branch) Extract, Nousenkazura (Lyoen flower) extract, Lotus (Lotus) extract, Chinese cabbage extract, Hadakamugi extract, Hanasuge (my mother) extract, Hermanus (Mykai flower) extract, Rose (Rose) extract, Barbasco extract, Spinach extract, Beech extract, American beech extract, Golden beech extract, European beech extract, Convolvulus extract, Hosobana okera extract (蒼朮) extract, Button (peony) extract, Mayoram (Annelida) extract, Melon extract, Oenothera extract, Snowy willow extract, Orchid extract, Lacanca extract, Rooibos extract, Naminoha Extract, Yukari extract, bombardier Yukari extract, Azusaekisu, basil extract, woodworking (climate) extract, and the like.

(8) Fat metabolism promoter Phthalazine derivatives (4-ethyl-1- (β-hydroxyethylamino) phthalazine, 4-N-propyl-1- (β-hydroxyethylamino) phthalazine, 4-N-butyl-1- (Β-hydroxyethylamino) phthalazine, 4-N-butyl-1- (β-hydroxypropylamino) phthalazine, etc.), xanthine derivatives (caffeine, theophylline, theobromine, xanthine, aminophylline, choline theophylline, diprofylline, proxyphylline and Oxtriphylline, etc.), Aotsuki-rafuji (wooden candy) extract, thistle extract, aletia thistle extract, white thistle extract, paddy thistle extract, noel thistle extract, blue thistle extract, cacao extract, elcampuri extract, otsu-rafuji (anti-self) extract, Gajuttsu (莪 朮) extract, Chrysanthemum salmon extract, Kyokyo (桔, Bellflower root) extract, kizuta extract, pepper (pepper) extract, cola acuminata extract, sageo modaka (sawabei) extract, pomelo extract, sanshuyu (yamabuchi) extract, tsuba rafuji extract, otsu ヅ rafuji extract, choreimaitake (bamboo shoot) extract, Rhizoma extract, primrose extract, red ginseng extract, ginseng extract (dragon gall) extract, naginata kouju extract, banana extract, puer tea (pure tea) extract, plum extract, boufu (windproof) extract, etc.

(9) UV protective agent / UV absorption accelerator Benzophenone derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid Sodium, dihydroxydimethoxybenzophenone, dihydroxydimethoxybenzophenone-sodium sulfonate, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), 1,2-dihydroxy-4- (2-hydroxyethyl) benzene derivatives (1- (2- ( 4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (6- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) ) Glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (2-acetyl-4- (3,4-dihydroxycinna)) Moyl) -3-rhamnosyl) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (2-acetyl-6- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3, 4-dihydroxybenzene, 1- (2- (4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (6- (4-hydroxy -3-methoxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) -1- Methoxyethyl-3,4-dihydroxybenzene, 1- (2- (4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) -1-hydroxyethyl-3,4-dihydroxybenzene, 1- ( 2- (6- (3,4-Dihydroxycinnamoyl) -3-xylosyl) glucosyl) ethyl-3,4-dihydride Roxybenzene, 1- (2- (3-Allosyl-6- (3-hydroxy-4-methoxycinnamoyl)) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (3-glucosyl-6- (3-hydroxy-4-methoxycinnamoyl)) glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (3-allosyl-6- (3-hydroxy-4-methoxycinnamoyl) glucosyl) Ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (4- (3,4-dihydroxycinnamoyl) glucosyl) ethyl) -3,4-dihydroxybenzene, 1- (2- (3- (3 4-dihydroxycinnamoyl) glucosyl) ethyl) -3,4-dihydroxybenzene, 1- (2- (2- (3,4-dihydroxycinnamoyl) glucosyl) ethyl) -3,4-dihydroxybenzene, 1- (2- (6- (3,4-Dihydroxycinnamoyl) glucosyl) ethyl) -3,4-dihydroxybenze Etc.), paraaminobenzoic acid derivatives (paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate, etc.), methoxycinnamic acid derivatives (ethyl paramethoxycinnamate, paramethoxycinnamon) Isopropyl acid, octyl paramethoxycinnamate, 2-ethoxyethyl paramethoxycinnamate, sodium paramethoxycinnamate, potassium paramethoxycinnamate, glyceryl di-2-methoxycinnamate mono-2-ethylhexanoate), anthranilic acid derivatives (such as methyl anthranilate), Urocanic acid derivatives (urocanic acid, ethyl urocanate, etc.), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, Dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives, pyridoxine derivatives, pyridoxal derivatives, pyridoxamine derivatives, amethoflavone, neosacranine, 6-dehydrocarbine, triazine derivatives (4,4'4 " -(1,3,5-triazine-2,4,6-triyltriimino) trisbenzoic acid tris-2-ethylhexyl, etc.), phosphatidyl chromanol derivatives (1,2-dilaurylglycero-3-phospho-2) '-Hydroxymethyl-2', 5 ', 7', 8'-tetramethyl-6'-hydroxychroman, 1,2-dimyristoylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1,2-dipalmitoylglycero-3-phospho-2'-hydroxymethyl-2', 5 ', 7', 8'-tetramethyl-6 ' -Hydroxychroman, 1,2-distealoy Luglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1,2-dialachidonylglycero-3-phospho-2'-hydroxy Methyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1-myristoyl-2-palmitoylglycero-3-phospho-2'-hydroxymethyl-2', 5 ', 7' , 8'-Tetramethyl-6'-hydroxychroman, 1-myristoyl-2-stearoylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'- Hydroxychroman, 1-palmitoyl-2-myristoylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1-palmitoyl-2-stearoyl Glycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1-stearoyl-2-myristoylglycero-3-phospho-2'-hydroxy Methyl-2 ', 5', 7 ', 8'- Tetramethyl-6'-hydroxychroman, 1-stearoyl-2-palmitoylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, etc.) , L-carnosine zinc complex, umbelliferone, esculin, benzyl cinnamate, cinoxalate, oxybenzone, dioxybenzone, octabenzone, soribenzone, benzoresorcinol, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, neoheliopan, chlorophylls, xanthophylls , Escalol, Zinc Oxide, Talc, Kaolin, Ansokcho (benzoic acid) extract, Hub extract, Giant puffer extract, Assamirisiogususa extract, Kawachigusa extract, Kawatake extract, Cypridosa extract, Hassai extract, Spirulina extract, Iaciocio Extract, Funori no Ushike extract, Himegususa extract, Hytengususa extract, Oobusa extract, Chinomori extract, etc.

(10) Astringents Succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc p-phenol sulfonate, potassium aluminum sulfate, resorcin, ferric chloride, tannins (tannic acid, hamellitannin, Acer Gallotannins such as tannin, tetragalloyl glucose, pentagalloyl glucose, hexagalloyl glucose, heptagalloyl glucose, octagalloyl glucose, nonagaroyl glucose, decagalloyl glucose, undecagalloyl glucose, dodecagalloyl glucose , Telimaglandin I, Telimaglandin II, Casarictin, Peducraggin, Geraniin, Isotarkebin, Granatin A, Granatin B, Kevulinic acid, Kebraguic acid, Casuarinine, Nufarin, Procyanidin B-2, Thiasici Elsin tannins such as cincin A and thiacinensin B), red grape extract, red bean extract, altea extract, nettle extract, cascarilla extract, kapoch extract, guarana extract, ezo strawberry extract, Dutch strawberry extract, shrimp strawberry extract , Nawashiro Strawberry Extract, Maple Strawberry Extract, European Raspberry Extract, Kidney Aloe Extract, Hawthorn Extract, Coustella Hakka Extract, Cowberry (Etsutachibana) Extract, Cola Vera Extract, Sugarcane Extract, Sinah Honoki Extract, Honeysuckle Extract Q) Extract, larch extract, elder extract, dandelion extract, centalium extract, white dandelion extract, mud dandelion extract, cranberry extract, tsurutsia Shrimp Extract, Teuchigurumi Extract, Tormentilla Extract, Novara Extract, Buttercup Extract, Hagoromogusa Extract, Castor Extract, Grape Extract, Prunes Extract, Veronica Extract, Bisnaga Extract, Bilberry Extract, Mansuguru Extract, Mitsugashi Extract, Myrrh Extract, Melissa Extract, Mansaku Extracts, Doroyanagi Extract, Latania (Clamelia) Extract, Lemon Extract, Daisy Extract, etc.

(11) Anti-inflammatory agent / interleukin production inhibitor / histamine release inhibitor quinolinone derivatives, dibenzooxepin derivatives, thiotroposin, phthalimide derivatives, flurbiprofen, felbinac, bufexamac, suprofen, 1,4-diphenylpropylpiperazine derivatives , Carxin compound, chromanol glycoside (2- (α-D-glucopyranosyl) methyl-2,5,7,8-tetramethylchroman-6-ol), ictamol, indomethacin, kaolin, diphenhydramine hydrochloride, d-camphor, DL-camphor, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, diphenhydramine hydrochloride, clemastine fumarate, cyproheptadine hydrochloride, prometa hydrochloride , Piperazine derivatives, α-D-phenylglycoside derivatives, glycyrrhizic acid or its salts and derivatives thereof (α-glycyrrhizic acid, β-glycyrrhizic acid, α-glycyrrhizic acid methyl ester, β-glycyrrhizic acid methyl ester, α-glycyrrhizin Trisodium acid, monopotassium α-glycyrrhizinate, dipotassium α-glycyrrhizinate, monoammonium α-glycyrrhizinate, trisodium β-glycyrrhizinate, monopotassium β-glycyrrhizinate, dipotassium β-glycyrrhizinate, monoammonium β-glycyrrhizinate ), Glycyrrhetinic acid or salts thereof and derivatives thereof (α-glycyrrhetinic acid, β-glycyrrhetinic acid, stearyl of α-glycyrrhetinic acid, stearyl of β-glycyrrhetinic acid, pyridoxine of α-glycyrrhetinic acid, β-glycyl Pyridoxine retinoate, α-glycyrrhetinic acid glycerin, β-glycyrrhetinic acid glycerin, 3-succinyloxyglycyrrhetinic acid disodium, etc.), mefenamic acid, phenylbutazone, ibuprofen, ketoprofen, allantoin, calcium pantothenate, pantothenyl ether, etc. Panthenol or salts thereof and derivatives thereof, ε-aminocaproic acid, diclofenac sodium, tranexamic acid or derivatives thereof (trans-4-benzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-nitrobenzyloxycarbonylaminomethylcyclohexane) Carboxylic acid, trans-4-p-chlorobenzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-bromobenzyloxycarbonylaminomethyl Cyclohexanecarboxylic acid, trans-4-m-chlorobenzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-methoxybenzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-methylbenzyloxycarbonylaminomethylcyclohexane Carboxylic acid, sodium trans-4-benzyloxycarbonylaminomethylcyclohexanecarboxylate, ammonium trans-4-p-nitrobenzyloxycarbonylaminomethylcyclohexanecarboxylate, potassium trans-4-p-chlorobenzyloxycarbonylaminomethylcyclohexanecarboxylate Trans-4-p-bromobenzyloxycarbonylaminomethyl potassium cyclohexanecarboxylate, trans-4-m-chlorobenzyloxycarbonylaminomethyl Calcium cyclohexanecarboxylate, magnesium trans-4-p-methoxybenzyloxycarbonylaminomethylcyclohexanecarboxylate, trans-4-p-methylbenzyloxycarbonylaminomethylcyclohexanecarboxylic acid monoethanolamine, trans-4-t-butyloxy Carbonylaminomethylcyclohexanecarboxylic acid, trans-4- (2-phenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (p-biphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (3, 5-Dimethoxyphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (p-methylphenylisopropyloxycarbonylaminomethyl) cyclohexa Carboxylic acid, sodium trans-4-t-butyloxycarbonylaminomethylcyclohexanecarboxylate, potassium trans-4- (2-phenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylate, trans-4- (p-biphenylisopropyloxycarbonylamino) Methyl) calcium cyclohexanecarboxylate, trans-4- (3,5-dimethoxyphenylisopropyloxycarbonylaminomethyl) magnesium cyclohexanecarboxylate, trans-4- (p-methylphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid monoethanolamine , Trans-4- (9-fluorenylmethyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4-methylsulfonylethyloxycarbonylaminomethyl Cyclohexanecarboxylic acid, sodium trans-4- (9-fluorenylmethyloxycarbonylaminomethyl) cyclohexanecarboxylate, potassium trans-4-methylsulfonylethyloxycarbonylaminomethylcyclohexanecarboxylate, trans-4- (pyridine-4 '-Methyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (2,2,2-trichloroethyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (2-trimethylsilylethoxycarbonylaminomethyl) cyclohexanecarboxylic acid Potassium, sodium trans-4- (pyridine-4'-methyloxycarbonylaminomethyl) cyclohexanecarboxylate, trans-4- (2,2,2-trichloroethyloxycarbonylaminomethyl) cyclohexanecarboxylic acid Potassium, trans-4- (2-trimethylsilylethoxycarbonylaminomethyl) cyclohexanecarboxylate, etc.), sulfatide, astaxanthin fatty acid diester (astaxanthin dilaurate, astaxanthin dimyristate, astaxanthin dipentadecanoate, astaxanthin dipalmitate) Ester, astaxanthin dipalmito oleate, astaxanthin diheptadecanoate, astaxanthin dielaidate, astaxanthin diricinoleate, astaxanthin petrolinate, astaxanthin vacsenate, astaxanthin eleostearate, astaxanthin punicin Acid ester, astaxanthin ricin Acid ester, astaxanthin parinaric acid ester, astaxanthin gadoric acid ester, astaxanthin 5-eicosenoic acid ester, astaxanthin 5-docosenic acid ester, astaxanthin cetoric acid ester, astaxanthin erucic acid ester, astaxanthin 5,13-docosadienoic acid ester, astaxanthin Ceracholate, Astaxanthin Decenoate, Astaxanthin Steringate, Astaxanthin Dodecenoate, Astaxanthin Dioleate, Astaxanthin Distearate, Astaxanthin Dieicosapentaenoate, Astaxanthin Didocosahexaenoate, Astaxanthin Dilinoleate, Astaxanthin Dilinolenic acid es , Astaxanthin diarachidonic acid ester, etc.), astaxanthin diglycerophosphate (astaxanthin diglycerophosphate, astaxanthin lyserophosphate palmitic acid, astaxanthin lyserophosphatidylcholine palmitic acid, astaxanthin lyserophosphatidylcholine DHA, astaxanthin lyserophosphati Diluinositol palmitic acid, astaxanthing lyserophosphatidylinositol DHA, astaxanthing lyserophosphatidylinositol linoleic acid, astaxanthing lyserophosphatidylcholine linoleic acid, steviol glycoside, benzimidazole derivatives (1- (2-ethoxyethyl) -2- [1- (2- (4- (1- (4,4-Dimethyl-2-oxazolin-2-yl) -1-methylethyl ) Phenyl) ethyl) piperidin-4-yl] -1H-benzimidazole, 2- [4- (2- (4- (1- (2-ethoxyethyl) benzimidazol-2-yl) piperidin-1-yl) Ethyl) phenyl] -2-methylpropanoic acid, ethyl 2- [4- (2- (4- (1- (2-ethoxyethyl) benzimidazol-2-yl) piperidin-1-yl) ethyl) phenyl]- 2-methylpropanate, 1- (2-ethoxyethyl) -2- [1- (2- (4- (1,1-dimethyl-2-hydroxyethyl) phenyl) ethyl) piperidin-4-yl] -1H -Benzimidazole, 1- (2-hydroxyethyl) -2- [1- (2- (4- (1- (4,4-dimethyl-oxazolin-2-yl) -1-methylethyl) phenyl) ethyl) Piperidin-4-yl] -1H-benzimidazole, 2- [4- (2- (4- (1- (2-hydroxyethyl) benzoimidazol-2-yl) piperidin-1-yl) ethyl) phenyl]- 2-methyl Lopanic acid, etc.), alanine derivatives or salts thereof (N- {3-isopentyl-4-methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H-thiazoline-5-carbonyl} -L- Alanine, N- {3-isopentyl-4-methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H-thiazoline-5-carbonyl} -2-methylalanine, N- {3-isopentyl -4-methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H-thiazoline-5-carbonyl} -N-methyl-L-alanine), thiazoline derivatives or salts thereof (3-isopentyl) -4-methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H-thiazoline-5-carboxylic acid, 4-isobutyl-3-methyl-2- [4- (3-trifluoromethyl) Benzamido) benzoylimino] -3H-thiazoline-5-carboxylic acid) , Chlorpheniramine maleate, diphenhydramine hydrochloride, diphenylpyraline hydrochloride, carbinoxamine maleate, hydrocortisone butyrate, sulfated acid mucopolysaccharide or salt thereof, sulfated dextran or salt thereof, licorice extract, sicon extract, age extract, propolis, eye ( Aiba) extract, Asenyaku (Asen Yaku) extract, Avocado extract, Amadokoroko (Tamatake) extract, Amigasayuri extract, Baimo (shellfish) extract, Igakozolina (Gall head) extract, Ibukitorano extract, Turmeric (Condensate) extract , Echinacea (Prunus japonicus) extract, Oren (Yelen) extract, Oguruma (turned over) extract, Hypericum (brutish cut grass) extract, Oniguri extract, Orange extract, Cassia extract, Kamiyatsu (weed) extract, Kawamidori extract, Kawamomogi )extract Watercress extract, Kenashi sartorini rose (Tsumago, Yamakage) extract, Gentianana extract, Koki Sekkokoku extract, Kouhon (Kakimoto, Karatsumoto) extract, Koryokyo (Kora bonsai) extract, Gosho strawberry (covered bonsai) extract, Saihailan extract, Cherry extract, Salvia (sage) extract, squirrel extract, linden extract, salamander extract, indian sea bream extract, shukushamitsu (sand seed, condensed sand) extract, juzudama extract, shirominanten (southern tenseed) extract, squirrel squirrel extract, psyllium serrata Extract, Achillea millefol (milfoil) extract, Hirosanega extract, Takasago Gurihigotai (southeast indigo sashimi) extract, Takara-bi (Kashiwaji) extract, Periwinkle extract (Marika) extract, Tamazaki tsumugi rafu extract, Tonin extract, Chigaya Eki , Toga (winter coconut) extract, Dokudami (ten-drug) extract, Parsley (Dutch jelly) extract, Hanabishi (shitsushishi, shishitsuri) extract, Hamasge (kotsuko) extract, Hishi (hijimi) extract, belude oyster extract, Fuyukazura ( (South rattan) extract, bundo (mung bean) extract, sandalwood extract, butcher bloom extract, pansy extract, Hosoba Abragik (bitter jelly) extract, Mizurutennansho (Tennansei) extract, pheasant (fruit berry) extract, miracle fruit extract, mulberry extract, Peach (peach) extract, cornflower extract, gourd willow extract, mistletoe (willow parasite) extract, Yabukouji (purple gold beef) extract, sagebrush extract, mugwort (bamboo leaf) extract, rosemary (mannenrou) extract, Japanese bean sprout extract, ftjusmo Extract, Tamajuzumo Extract, Mizojuzumo Extract, Urushi Gusa extract, Quercus gulsa extract, Sardine beard extract, Red mushroom extract, Togemoku extract, Aqaba extract, Maruba red mushroom extract, Scallop extract, Dulse extract, Yuna extract, Belladonna extract, Hoonoki extract, Haruni extract (skin peel, white skin, maple leaf) extract, Aozuzuran Extracts, Sakaneran extract, Sasabagin orchid extract, Husambird (including varieties and origins) extract, etc.

(12) Anti-seborrheic agent Chroman derivatives, pyridoxine or salts thereof and derivatives thereof, pyridoxal or salts thereof and derivatives thereof, pyridoxamine or salts thereof and derivatives thereof, sulfur, Asa (Asakojin) extract, Odorikosou (continuous) ) Extract, Dutch mustard (watercress) extract, valerian extract (valerian root) extract, clematis extract, bear sebacekis, savonsou extract, rosewood extract, horse chestnut extract, soybean (soybean) extract, eucalyptus (marigold) extract, potato extract, Yamano potato extract, Nosenhalen extract, Fukitan popo (Section winter flower, Sect winter winter leaf) extract, Yabugarashi extract, Giant kelp extract, Hijirimen extract, Proboscis extract, Haius banori extract, etc.

(13) Antibacterial agent Acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or hydrolyzate thereof, alkyldiaminoethylglycine chloride solution, triclosan, sodium hypochlorite, chloramine T, salami powder, iodine Compound, iodoform, 1-alkylcarbapenem compound, N-substituted azepane derivative or salt thereof, sorbic acid or salt thereof, propionic acid or salt thereof, salicylic acid or salt thereof, dehydroacetic acid, parahydroxybenzoic acid ester, 2-keto -3-deoxyoctanoic acid fatty acid ester, inositol deoxy derivatives (such as quercitol), inositol unsaturated derivatives (such as chonditol), inositol dimethyl ether, methyl inositol, inositol methyl ether Inosamine, deoxyinosadiamine, shikimic acid, quinic acid, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p-chloro-m-xylenol, p-chloro-m-cresol, thymol , Phenethyl alcohol, o-phenylphenol, Irgasan CH3565, halocarban, hexachlorophene, chlorohexidine, ethanol, methanol, isopropyl alcohol, benzyl alcohol, ethylene glycol, propylene glycol, 2-phenoxyethanol, 1,2-pentanediol, zinc pyridione , Chlorobutanol, isopropylmethylphenol, elemol, vetiverol, patchouli alcohol, nonionic surfactant (polyoxyethylene lauryl ether, polyoxyethylene Nonylphenyl ether, polyoxyethylene octylphenyl ether, etc.), amphoteric surfactant, anionic surfactant (sodium lauryl sulfate, lauroyl sarcosine potassium, etc.), cationic surfactant (cetyltrimethylammonium bromide, benzalkonium chloride, chloride) Benzethonium, methyl rosaniline chloride), formaldehyde, hexamine, brilliant green, malachite green, crystal violet, jamal, photosensitizer 101, photosensitizer 201, photosensitizer 401, N-long chain acyl basic amino acid derivatives and acid addition salts thereof , Zinc oxide, hinokitiol, propolis, kudin extract, agi extract, asunalo extract, alpinia extract, katsudai (suzukukku) extract, red-bellied extract, red-tailed dragonfly Extract鈎) Extract, Kahoku Salamander (蜀椒) Extract, Chamomile Extract, Kinakiki Extract, Red linden extract, Yellow Spider Extract, Caraway Extract, Betel Extract, Kumazasa Extract, Cranberry Extract, Grapefruit Extract, Celosia (Chicken Flower, Chicken Crown) ) Extract, bay bay laurel extract, Koushinbara (monthly flower) extract, copaiba balsam extract, mountain cherry extract, ed pear extract, Miyaza cherry extract, Yoshino cherry extract, Kasami cherry extract, Kanza cherry extract, sugar beet Extract, Sarasinashouma (Hemp) extract, Shimushi (Mikoshi) extract, white birch extract, cinnamon extract, sorrel (acid mimic) extract, dandelion extract, Nezu (Pine pine) extract, Japanese mint extract, Japanese wild mint extract, Soka ( (Grass) extract, onion extract, chicory extract, ginseng extract, tsuruna extract, tokon extract, leek extract, leek extract, peach extract, patchouli extract, ganbanana ( Sarcophagus, vine pearl shahua) extract, cypress extract, pimenta extract, cypress extract, white hazel extract (black bald eagle) extract, blackberry extract, hop extract, makuri (marine herb) extract, magnolia sprenger extract, mizokakushi (half) Lotus) extract, bee extract, purple (purple) extract, moso-chiku extract, Pokeweed (commercial and commercial) extract, yucca extract, euglena extract, lavender extract, forsythia extract, syringen extract, prunus nomata extract, tochaka (yahazuzumata) extract, red-bellied extract, anaaosa extract, human rush extract, hirohano Human rush extract, Ushiro rush extract, Iroro extract, Ishige extract, Alame extract, Tamai taki extract, Tambanori extract, Katanori extract, Sakuranori extract, Fujimatsumo extract, Kawamozuku extract, Aokawa Mozuku extract, Himekawa Mozuku extract, Yakuchi (Yoshichi) extract, etc.

(14) Blood flow promoter / vascular stimulator Tocopherol or its salt and derivatives thereof, tocotrienol or its salt and derivatives thereof, cephalanthin, carpronium chloride, eugenol derivatives (acetyl eugenol, methyl eugenol, methyl isoeugenol, ethyl eugenol, ethyl Isoeugenol, eugenol salicylate, etc.), minoxidil, chili pepper tincture, nonyl acid vanillamide, cantalis tincture, pepper tincture, peppermint oil, L-menthol, camphor, benzyl nicotinate, cinnarizine, trazoline, acetylcholine, verapamil, ictamol, α- Borneol, cyclandelate, nonyl acid wallenylamide, capsaicin, gingerone, assembly extract, garlic extract, carrot extract, aloe exhaust , Gentiana extract, Toki extract, Ashitaba (tomorrow) extract, Arnica extract, Yukiyara (Sanriku) extract, Hime wikyou extract, Citrus unshiu (Chen skin) extract, Toucan beetle (coconut) extract, Oyster extract, Kaki extract, Kina extract, Ginseng hen extract, pine moth (horse whip grass) extract, kubijinsou extract, kohone (river bone) extract, burdock (beef bowl, beef coconut) extract, scallop (mountain curd) extract, syringen extract, ginger (ginger) extract, ginger (ginger)菖蒲, Sone) extract, Hawthorn extract, Seburi extract, Daidai extract, Tanjin extract, Thyme extract, Chikutsutsujinjin (Takebushi ginseng) extract, Tsurugokudami extract, Tsurunjinjin (Yotei ginseng) extract, chili pepper (banban) extract, toki (tokiwa) extract, chili Mimochi (Female Sadako) extract, Natsumikan extract, Elderberry (bone grafting) extract, Hazel (coconut) extract, Hasidorokoro (roth root) extract, mint (light load, thin load leaf) extract, Hamabou Fu (hama wind) extract, Higotai extract, Fujimodoki ( Clover cherry tree, strawberry flower) extract, black currant extract, bodaiju (bamboo tree) extract, merirot extract, yuzu extract, wintersweet extract, bay jelly extract, hibiscus extract, rosehip extract, etc.

(15) Antiandrogens Follicular hormones (estrone, estradiol, ethinyl estradiol, etc.), isoflavones, oxendron, 4 ', 5,7-trihydroxy-8-prenylflavanone, 4', 5,7-trihydroxy-8-prenyl Flavone, 3,3 ′, 4 ′, 5,7-pentahydroxy-8-prenylflavone, nicorandil, cyclosporic acid and the like.

(16) Inhibitors of structural proteolytic enzymes (malastase, elastase, collagenase, keratin protease, serine protease, integrin degrading enzyme, involucrin degrading enzyme, filaggrin degrading enzyme, laminin degrading enzyme, fibronectin degrading enzyme, proteoglycan degrading enzyme) / Structural proteolytic enzyme expression inhibitor Adenine derivatives (butanetriol-9-adenine and its phosphate adduct, propanediol-9-adenine and its phosphate adduct, pentanetriol-9-adenine and its phosphate adduct, etc. ), Carbostyril derivatives or salts thereof, dicarboxylic acids (glutaric acid, adipic acid, pimelic acid, suberic acid, azelaic acid, sebacic acid, 1,9-nonamethylenedicarboxylic acid, 1,10-decamethylenedicarboxylic acid), rosuma Acid, ursolic acid, oleanolic acid, hydroxamic acid derivative, esculetin derivative, anthocyanidins, nordihydroguaiaretech acid, 20-carboxy-16-hydroxy-21-nor-5 α-7,9 (11) -lanostadien- 3,24-dione, ubiquinone, plataquinone, yuglone, shikonin, quinizarin, alizarin, abietin, levopimar, betulin, α-amylin, catechin compounds (catechin, epigallocaequine, epigallocatechin gallate, epicatechin, epicatechin gallate, catechin ram Nopyranoside catechin, etc.), diisopropyl fluorophosphate, (2R, 6R) -2,6-dihydroxy-4- (tert-butyldimethylsilyloxy)-(3Z) -heptene-1,7-dicarboxylate, N, N'-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R) -2,6-dibenzyloxy-4-hydro Siheptanedicarboxylic acid-1,7-diamide, (2R, 6R) -2,6-dihydroxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylate, (2R, 6R) -2 , 6-Dibenzyloxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylate, (2R, 6R) -2,6-dibenzyloxy-4- (tert-butyldimethylsilyloxy) ) Heptane-1,7-dicarboxylic acid, N, N′-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R) -2,6-dibenzyloxy-4- ( tert-Butyldimethylsilyl) oxyheptane-1,7-dicarboxylic acid diamide, N, N'-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R) -2,6- Dibenzyloxy-4-hydroxyheptane-1,7-dicarboxylic acid diamide, N, N′-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R) -2,4, 6-Trihydroxyheptane-1,7-dicarboxylic acid diamide, N, N'-bis [(1S, 2R) -2- Droxyindan-1-yl]-(2S, 6S) -2,6-dibenzyloxy-4-hydroxyheptane-1,7-dicarboxylic acid diamide, (2S, 6S) -2,6-dihydroxy-4- (tert -Butyldimethylsilyloxy)-(3Z) -heptene-1,7-dicarboxylate, (2S, 6S) -2,6-dihydroxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylic acid Dimethyl acid, (2S, 6S) -2,6-Dibenzyloxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylate, (2S, 6S) -2,6-dibenzyloxy -4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylic acid, N, N'-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2S, 6S) -2 , 6-Dibenzyloxy-4- (tert-butyldimethylsilyl) oxyheptane-1,7-dicarboxylic acid diamide, N, N'-bis [(1S, 2R) -2-hydroxyindan-1-yl]- (2R, 6R) -2,6-Dibenzyloxy-4-hydroxy Heptane-1,7-dicarboxylic acid diamide, 3-[[4- (4-fluorophenoxy) -benzenesulfonyl]-(1-hydroxycarbamoylcyclopentyl) -amino] -propionic acid, 4- [4- (4-fluoro Phenoxy) -benzenesulfonylamino] -tetrahydropyran-4-carboxylic acid hydroxyamide, 4- [4- (4-chlorophenoxy) -benzenesulfonylmethyl] -tetrahydropyran-4-carboxylic acid hydroxyamide, 3-[[4 -(4-Fluorophenoxy) -benzenesulfonyl]-(1-hydroxycarbamoylcyclobutyl) -amino] -propionic acid, 4- (4'-chlorobiphenyl-4-yl) -2- [2- (1,3 -Dioxo-1,3-dihydroisoindol-2-yl) -ethyl] -4-oxobutyric acid, {1- [4- (4-fluorobenzyloxy) -benzenesulfonyl] -2-hydroxycarbamoylpiperidine-3- Il -Carbamate isopropyl ester, 2- [4- (4-fluorophenoxy) -benzenesulfonylamino] -N-hydroxy-2-methylfuropionamide, 3- [4- (4-fluorophenoxy) -benzenesulfonyl]- 2, N-dihydroxyfuropionamide, 3- (4-phenoxybenzenesulfonyl) -7-oxabicyclo [2.2.1] heptane-2-carboxylic acid hydroxyamide, (4-benzylbenzyl)-[2- (2, 2-Dimethyl-1-methylcarbamoylpropylcarbamoyl) -4- (4'-fluorobiphenyl-4-yl) -butyl] -phosphinic acid, 2-amino-3- [4- (4-fluorophenoxy) -benzenesulfonyl ] -N-Hydroxypropionamide, and N-hydroxy-2- (4-phenylpiperidine-1-sulfonyl) -acetamide, Iris japonicum extract, Nepenthes extract Li (Banaba) extract, Omi hawthorn extract, Hawthorn (Yamako) extract, Calahoo (Park) extract, Guava extract, Shazenso extract, Rose rose extract, Hypericum perforatum extract, Octopus (breeding) extract, Hinata tadpole (cow knee) Extract, Honoki (Japanese Kobak, Park) Extract, American Grape Extract, European Grape Extract, Yama Grape Extract, Mandarin Extract, Mishima Psycho (Shibahu) Extract, Ogon Extract, Hypericum Extract, Clara Extract, Mulberry Extract, Keihi Extract, Genpachi Extract, Comfrey extract, salvia extract, elderberry extract, body sage extract, button pi extract, Aos zuran extract, sakaneran extract, sasabagin orchid extract, white clover (including varieties and origins) extract, etc.

(17) Structural protein synthesis promoter Ethanolamine derivative, pentoxyphyllin, serine derivative, geraniol, crocetin, methyl 4- (2-ethylhexyloxy) -2-hydroxybenzoate, 2-hydroxy-4- (3,5, 5-Trimethylhexyloxy) methyl benzoate, methyl 4-cyclohexylmethoxy-2-hydroxybenzoate, methyl 4- (2-cyclohexylethoxy) -2-hydroxybenzoate, 4- (3,7-dimethyl-6-oct Methyl tenenyloxy) -2-hydroxybenzoate, ethyl 3- (2-ethylhexyloxy) -5-hydroxybenzoate, methyl 5- (2-ethylhexyloxy) -2-hydroxybenzoate, 2-hydroxy-5- ( 3,5,5-Trimethylhexyloxy) methyl benzoate, methyl 5- (2-cyclohexylethoxy) -2-hydroxybenzoate, methyl 4-N-hexyloxy-2-hydroxybenzoate 2-methyl-4-N-octyloxybenzoate, methyl 4-N-decyloxy-2-hydroxybenzoate, methyl 5-N-hexyloxy-2-hydroxybenzoate, 4- (2-ethylhexyloxy) ) -2-hydroxybenzoic acid, 2-hydroxy-4- (2,5,5-trimethylhexyloxy) benzoic acid, 4-cyclohexylmethoxy-2-hydroxybenzoic acid, 4- (2-cyclohexylethoxy) -2- Hydroxybenzoic acid, 4- (3,7-dimethyl-6-octenyloxy) -2-hydroxybenzoic acid, 3- (2-ethylhexyloxy) -5-hydroxybenzoic acid, 5- (2-ethylhexyloxy)- 2-hydroxybenzoic acid, 5- (2-ethylhexyloxy) -2-hydroxybenzoic acid, 2-hydroxy-5- (3,5,5-trimethylhexyloxy) benzoic acid, 5- (2-cyclohexylethoxy)- 2-hydroxybenzoic acid, 4-N-hexyloxy-2-hydride Roxybenzoic acid, 5-N-hexyloxy-2-hydroxybenzoic acid, 2-hydroxy-4-N-octyloxybenzoic acid, 4-N-decyloxy-2-hydroxybenzoic acid, N- (2-hydroxyethyl) -4- (2-ethylhexyloxy) -2-hydroxybenzamide, N-ethyl-4- (2-ethylhexyloxy) -2-hydroxybenzamide, 2-acetoxy-4-cyclohexylmethoxybenzoic acid, 4- (2-ethylhexyl) Sodium oxy) -2-hydroxybenzoate, methyl 4-{(2E) -3,7-dimethyl-2,6-octadienyloxy} -2-hydroxybenzoate, 4-{(2E) -3,7 Ethyl 3-dimethyl-2,6-octadienyloxy} -2-hydroxybenzoate, ethyl 5-{(2E) -3,7 dimethyl-2,6-octadienyloxy} -2-hydroxybenzoate, 3 -{(2E) -3,7-dimethyl-2,6-octadienyloxy} -2-hydroxybenzoate, 3-{(2E) -3,7-dimethyl Ethyl 2,6-octadienyloxy} -5-hydroxybenzoate, ethyl 4-{(2E) -3,7-dimethyl-2,6-octadienyloxy} -3-methoxybenzoate, 4 -{(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy} -2-hydroxybenzoic acid methyl 4-{(2E) -3,7-dimethyl-2, 6-octadienyloxy} -2-hydroxybenzoic acid (2E) -3,7-dimethyl-2,6-octadienyl, 4-{(2E) -3,7-dimethyl-2,6-octadienyloxy } -2-hydroxybenzoic acid, 5-{(2E) -3,7-dimethyl-2,6-octadienyloxy} -2-hydroxybenzoic acid, 3-{(2E) -3,7-dimethyl- 2,6-octadienyloxy} -2-hydroxybenzoic acid, 3-{(2E) -3,7-dimethyl-2,6-octadienyloxy} -5-hydroxybenzoic acid, 2-hydroxy-4 -{(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy} benzoic acid, 4-{(2E) -3,7-dimethyl-2,6-octadi Nyloxy} -3-methoxybenzoic acid, 2-acetoxy-4-{(2E) -3,7-dimethyl-2,6-octadienyloxy} benzoic acid, N- (2-hydroxyethyl) -4- { (2E) -3,7-dimethyl-2,6-octadienyloxy} -2-hydroxybenzamide, 4-{(2E) -3,7-dimethyl-2,6-octadienylamino} -2- Hydroxybenzoic acid, dimethyl-2,6-octadienyloxy} benzoic acid, N- (2-hydroxyethyl) -4-{(2E) -3,7-dimethyl-2,6-octadienyloxy}- 2-hydroxybenzamide, 4-{(2E) -3,7-dimethyl-2,6-octadienylamino} -2-hydroxybenzoic acid, 3-dodecyloxybenzoic acid, 3- (12-hydroxydodecyloxy) Benzoic acid, 4-dodecyloxybenzoic acid, 4- (12-hydroxydodecyloxy) benzoic acid, 3- (12-hydroxyoctadecyloxy) benzoic acid, 4- (12-hydroxyoctadecyloxy) Benzoic acid, 3- (11-hydroxyundecyloxy) benzoic acid, 4- (11-hydroxyundecyloxy) benzoic acid, 3-[(2E) -3,7-dimethyl-2,6-octadienyloxy ] Benzoic acid, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] benzoic acid, 3-[(2E, 6E) -3,7,11-trimethyl-2,6, 10-dodecatrienyloxy) benzoic acid, 4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] benzoic acid, 4- [3,7-dimethyl- 9- (2,6,6-trimethyl-1-cyclohexen-1-yl) -2,4,6,8-nonatetraenyloxy] benzoic acid, 4- [3,4-dihydro-2,5,7 , 8-Tetramethyl-2- (4,8,12-trimethyltridecyl) -2H-1-benzopyran-6-oxy] benzoic acid, 4-[(2E, 6E) -3,7,11-trimethyl- 2,6,10-dodecatrienyloxy] benzamide, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] benzamide, 4- (2-methyl-2-butenyl Oxy) benzamide, 4- (2-ethylhexyloxy) benzamide, 4-dodecyloxybenzamide, 4- (12-hydroxydodecyloxy) benzamide, 4- (12-hydroxyoctadecyloxy) benzamide, 4- (11-hydroxyundecyl) Oxy) benzamide, 4- (10-hydroxydecyloxy) benzamide, 4-isostearyloxybenzamide, N- (2-hydroxyethyl) -4-[(2E, 6E) -3,7,11-trimethyl-2, 6,10-dodecatrienyloxy] benzamide, N, N-dimethyl-4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] benzamide, N, N -Di [(2E) -3,7-dimethyl-2,6-octadienyl] -4-aminobenzamide, 4- [N'-methoxycarbonyl-N-[(2E) -3,7-dimethyl-2,6 -Octadienylamino] benzamide, 4- [N-acetyl-N-[(2E) -3,7-dimethyl-2,6-octadi Nyl]] aminobenzamide, N- (2-hydroxyethyl) -4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] -2-hydroxybenzamide, N , N-diethyl-4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] -2-hydroxybenzamide, pea extract, tokamodoki extract, ikanoashi extract, hosoivo Nori Extract, Novonori Extract, Igis Extract, Keigi Extract, Harigi Extract, Hanegisu Extract, Usuba Watanagi Extract, Moray Togusa Extract, Fuyugusa Extract, Willow Willow Extract, Willow Tree Extract, Moyuyurena Extract, Vulgaris Extract, Mosayanagi Extract, Sasabayanaginori extract, Wasabi extract, etc.

(18) Mucopolysaccharide (hyaluronic acid, chondroitin sulfate, etc.) degrading enzyme inhibitors Anacardic acid or its derivatives (6-pentadecatrienylsalicylic acid methyl ether, 6-pentadecatrienylsalicylic acid ethyl ether, 6-pentadecatrienyl) Salicylic acid propyl ether, 6-pentadecatrienyl salicylic acid butyl ether, 6-pentadecatrienyl salicyl alcohol methyl ether, 6-pentadecatrienyl salicyl alcohol ethyl ether, 6-pentadecatrienyl salicyl alcohol propyl ether, 6-pentadeca Trienyl salicyl alcohol butyl ether, 6-pentadecatrienyl salicylaldehyde methyl ether, 6-pentadecatrienyl salicylaldehyde ethyl ether, 6-pentadecatrienyl salicylaldehyde propyl Ether, 6-pentadecatrienyl salicylaldehyde butyl ether, 2-methyl ether-6-pentadecatrienyl cinnamic acid, 2-ethyl ether-6-pentadecatrienyl cinnamic acid, 2-propyl ether-6-penta Decatrienyl cinnamic acid, 2-butyl ether-6-pentadecatrienyl cinnamic acid, 2-methyl ether-6-pentadecatrienyl cinnamic alcohol, 2-ethyl ether-6-pentadecatrienyl cinnamic alcohol , 2-propyl ether-6-pentadecatrienyl cinnamic alcohol, 2-butyl ether-6-pentadecatrienyl] cinnamic alcohol, etc.), polyisoprenylated benzophenone derivatives (garcinol, isogarcinol, xanthothymol, Isoxanthothymol, gucciferon, etc.), Ikarisou extract, Yachima Taikiso (Indoka) ) Extract, Narco Lily extract, Kaguluma Naruko Lily (Yellow) extract, Oregano extract, Oshida extract, Onji extract, Spruce extract, Crow Bishaku (semi-summer) extract, Pheasant (fruit berry) extract, wolfberry (枸杞, coconut, coconut leaf, crustal skin) ) Extract, Goshuyu (Kurei) extract, Senega extract, Sendan extract, Tamarind extract, Tarragon extract, Korean radish (Dahi) extract, Hachiku (Bamboo pod) extract, Daisies (Daisy) extract, Milobaran extract, Dromedary willow extract, Mockin Extract, Laurel extract, Yabusota extract, Anaaosa extract, Macrocystis integrofolia extract, Neocitus Ruetkeana extract, Nettle extract, Oats extract, Kata-bakusa extract, Yatabegusa extract, Shimatengusa extract, Ezotsunomatsue , Barbs horn Mata extract, Mrs. follower Uz data extract, Hanemoekisu, Miruekisu, Kuromiruekisu, Saki butyl mill extract, Nagamiruekisu, Hiramiruekisu, Matsumoekisu, Cladosiphon okamuranus extract, Nemacystus extract, bag glue extract, Kajimeekisu, bag funori extract, Mafunoriekisu like.

(19) Mucopolysaccharide synthesis promoter Stilbene derivative or salt thereof, morgin or salt thereof and derivatives thereof, N-acetylglucosamine, flax extract, cinnamon extract, mulberry extract, banana extract, bread extract, flounder extract, koto Gitznomata extract, Yaleus banori extract, Kagios banori extract, Susius banori extract, Amiaosa extract, Nagaaosa extract, Hosobanosasakamodoki extract, Hirohatosakamodoki extract, Yatsudegatatosakamodoki extract, Kurotosakamodoki extract, Nezano Sakamodoki Extract, Yusora Extract, Echinoki Sakamodoki Extract, Nankaito Sakamodoki Extract, Himeto Sakamodoki Extract, etc.

(20) intercellular adipogenesis promoter / intercellular lipid state improving agent phospholipids (phosphatidylethanol, phosphatidylcholine, phosphatidyltriethanolamine, phosphatidylserine, phosphatidic acid, phosphatidylglycerol, phosphatidylinositol, diacylphosphatidylcholine, diacylphosphatidylethanolamine, Diacyl phosphatidylinositol, diacyl phosphatidyl serine, 1-cysteinyl phosphatidic acid, 2-cysteinyl phosphatidic acid, 1-glutathionyl phosphatidic acid, 2-glutathionyl phosphatidic acid, 1-azelaoyl phosphatidic acid, 2-azela Oil phosphatidic acid, 1-hydroxyacylphosphatidic acid, 2-hydroxyacylphosphatidic acid, ceramide, glucosylceramide, Lactosylceramide, cerebroside, phosphatidylglucosylacylglycerol, N-oleoylsphingosine, N- (12-hydroxyoctadecanoyl) sphingosine, N- (16-hydroxyhexadecanoyl) sphingosine, N-salicyloylphytosphingosine, sphingo Myelin, soybean lecithin, egg yolk lecithin, etc.), sterins (cholesterol, dihydrocholesterol, cholesteryl stearate, cholesteryl hydroxystearate, macadamia nut oil fatty acid cholesteryl, β-sitosterol, stigmasterol, campesterol, ergosterol, 5-dihydroergo Sterol, phytosterol, 25-hydroxycholesterol, 26-hydroxycholesterol, 19-hydroxycholesterol, 22-ketocore Terol oxime, 6-ketocholesterol and 7-ketocholesterol or their derivatives), N-acetylneuraminic acid (sialic acid), N-glucosolneuraminic acid, gangliosides (galaose, ganglytriaose, gangliatetraose , Globotetraose, neolactotetraose, neolactohexaose, neolactooctaose, etc.), oligosulfated hyaluronic acid, hydroxytamoxifen compounds, glyceroglycolipids, pentoxyferrin, 3-deazaadenosine, carboxysamide Derivatives, Inositol polyamines, Sialic acid, Triterpenic acid derivatives, Lactose, Lactosamine derivatives, Sulfated chitin derivatives, Albumin, Panax ginseng extract, Tochiban ginseng extract, Oni lily extract, Sasa lily extract, Hakata lily Kiss, poppy extract, and the like.

(21) Keratolytic agent / stratum corneum exfoliation accelerator Tropolone and its derivatives, resorcin, lactic acid, urea, salicylic acid, guanidine, ethanolamine, kikarasuuri (Gurone) extract, fenugreek extract, wisteria bean extract, lentil extract, chickpea Extract, mungbean extract, etc.

(22) Plasminogen activator antagonist inhibitor Rabbit daisy extract, canamgra extract, caladium extract, raspberry extract and the like.

(23) Maillard reaction inhibitor Aminoguanidine, flavanones (naringin, naringenin, naringin, naringenin, liquiritin, liquiritigenin, digallic acid, luteoic acid, ellagic acid, chlorogenic acid, glucogallin, tetralin, hamellitannin, tannic acid tannin, Tannic acid, geraniin, gallic acid, galloyl gallic acid, ellagitannin, hexagalloyl glucose, heptagalloyl glucose, tetragalloyl glucose, trigoloyl glucose, pentagalloyl glucose, digalloyl quinic acid, triguloyl quinic acid), 2- Hydroxyphenylalkylamine derivatives or salts thereof, phenylpropenoic acid derivatives (3- [2,3-bis (methoxymethoxy) phenyl] propenoic acid, 7- (4-hydroxy-3-methoxyphenyl) hepta-2,4,6 -Trienoic acid, 3- (3,5-dimethoxy-4-hydroxyphenyl) propenohydrazide, N'-isopropylidene-3- (2-methoxyphenyl) propenohydrazide, etc.), gypsum extract, sandalwood extract, etc. .

(24) Testosterone 5α reductase activity inhibitor γ-amino-β-hydroxybutyric acid esters (γ-amino-β-hydroxybutyric acid methyl ester, γ-amino-β-hydroxybutyric acid ethyl ester, γ-amino-β-hydroxybutyric acid) Propyl ester, γ-amino-β-hydroxybutyric acid butyl ester, γ-amino-β-hydroxybutyric acid ethylhexyl ester, γ-amino-β-hydroxybutyric acid hexadecyl ester, γ-amino-β-hydroxybutyric acid lauryl ester, γ- Amino-β-hydroxybutyric acid stearyl ester, γ-amino-β-hydroxybutyric acid oleyl ester, γ-amino-β-hydroxybutyric acid benzyl ester, γ-amino-β-hydroxybutyric acid phenyl ester, γ-amino-β-hydroxybutyric acid Ethyl glycol ester, γ-amino-β-hydroxybutyric acid sorbitol ester, γ-amino-β-hydride Loxybutyric acid polyoxyethylene glycol ester, γ-amino-β-hydroxybutyric acid glycerin ester, etc.), amine oxides (oleyldimethylamine oxide, stearyldimethylamine oxide, palmityldimethylamine oxide, myristyldimethylamine oxide, lauryldimethylamine oxide) Dimethyl lauryl ethoxyamine oxide, dihydroxyethyl lauryl amine oxide, coconut oil alkyl dimethyl amine oxide, etc.), alkyl betaines (coconut oil fatty acid amide propyl betaine, coconut oil alkyl betaine, lauryl dimethylaminoacetic acid betaine, lauric acid amide propyl betaine, Laurylhydroxysulfobetaine, 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine), Midine N-oxide derivatives (2-amino-4-methyl-6-piperidinopyrimidine-3-oxide, 2-amino-4-methyl-6- (1-pyrrolidinyl) pyrimidine-3-oxide, 2-amino- 4-methyl-6-morpholinopyrimidine-3-oxide, 2-amino-4-methyl-6- [1- (4-methylpiperazinyl)] pyrimidine-3-oxide, 2-amino-4- (1 -Hexahydroazepinyl) -6-methylpyrimidine-1-oxide, 2-amino-4-dimethylamino-6-methylpyrimidine-1-oxide, 2-amino-4-allylamino-6-methylpyrimidine-1- Oxide, 2-amino-4-benzylamino-6-methylpyrimidine-1-oxide, 2-amino-4,5-methyl-6-piperidinopyrimidine-3-oxide, 2-amino-4-ethyl-6 -Morpholinopyrimidine-3-oxide, 2-amino-4-methyl-5-nitro-6-piperidinopyrimidine-3-oxide, 2,5-diamino-4-methyl-6-piperidinopi Limidine-3-oxide, 2-amino-4-methyl-5,6-bis (1-pyrosinyl) pyrimidine-3-oxide, 2-amino-4-methyl-5-piperidino-6- (1-pyrrolidinyl) pyrimidine -3-oxide, 2-methyl-4-amino-6-piperidinopyrimidine-3-oxide, 2-methyl-4-amino-5-bromo-6- (1-pyrosinyl) pyrimidine-3-oxide, 2 -Methyl-4-amino-5-nitro-6-piperidinopyrimidine-3-oxide, 2-methyl-4,5-diamino-6-piperidinopyrimidine-3-oxide, 2-methyl-4-amino -5,6-bis (1-pyrrolidinyl) pyrimidine-3-oxide, 2-amino-4-methyl-6-piperidinopyrimidine-3-oxide monohydrochloride, 2-acetylamino-4-methyl-6- Piperidinopyrimidine-3-oxide, 2,4-diamino-6-phenoxypyrimidine-3-oxide, 2,4-diamino-6- (2,4-dichlorophenoxy) pyrimidine-3-oxide, 2,4- Diamino-6- (2 , 4,6-Trichlorophenoxy) pyrimidine-3-oxide, 2,4-diamino-5-nitroso-6- (2,4-dichlorophenoxy) pyrimidine-3-oxide, 2,4-diamino-5-nitro- 6- (2,4,6-trichlorophenoxy) pyrimidine-3-oxide, 2,4-diamino-5-nitro-6- (2,4-dichlorophenoxy) pyrimidine-3-oxide, 2,4,5- Triamino-6- (2,4-dichlorophenoxy) pyrimidine-3-oxide, 2,4-diamino-5-bromo-6- (2,4-dichlorophenoxy) pyrimidine-3-oxide, etc.), p-menthane- 3,8-diol, monoglyceryl-D-glucoside monotridecanoate, 1-oN-pentadecylglycero-D-glucoside, monopentadecanoic acid glyceride sulfate, etc. glyceride sulfate, monopentadecyl Glyceryl ether sulfate, 1-o-hexadecyl-2-o-methylglycerol, 1-o-octadecyl -2-o-methylglycerol, 1-o-oleyl-2-o-methylglycerol, acetylcarnitine or its salt, geranylgeranylacetone, hydroxamic acid derivative or its salt, gingerone glycoside, benzeneoxyacetic acid derivative ([5- [2- [1-phenyl-1- (3-pyridyl) methylideneaminooxy] ethyl] -7,8-dihydronaphthalen-1-yloxy] acetic acid, etc.), isorhamnetin-3-robinobioside, xanthone derivatives , Proanthocyanidins (grape seed extract proanthocyanidins, apple-derived proanthocyanidins, pine-derived proanthocyanidins, purified procyanidin oligomers, procyanidin B-1, procyanidin B-2, procyanidin B-3, procyanidin C-1 etc.), aracaci extract , Angelica extract, Anse extract, Honzu extract, Ichiyakuso Cormorant (one medicinal herb) extract, licorice extract, psyllium (carlet child, carve herb) extract, psyllium shabushi extract, olive extract, giant dogfowl extract, seisei extract, calla cucumber extract, cinnamon crocodile extract Extract, Catalpa extract, Kukui nut extract, Camphor tree extract, Kubaba extract, Black-bellied red extract, Snapper extract, Snapdragon extract, Snapdragon extract, Kippi extract, Japanese beetle extract, Cilantro extract, Kobushi extract, Mokuren extract, Sanekazu extract , Colombo extract, Conslango extract, Sasanqua extract, Sweet potato extract, Sanebuto jujube (acid soy sauce) extract, Sandscon (Yamazu root) extract, Potato extract, Shishigashira extract, Nashishi extract, coriander extract, stevia extract, Takatodai extract (Otsuka) extract, Tarayo (Oba winter blue, Ichiha tea, bitter tea, bitter tea) extract, taranoki extract, nigaki (Nakiki) extract, Nurde (penta) extract, hakama Urabosi (bone crush) extract, spider magnolia extract, scented squirrel extract, stag beetle extract, sorghum grass extract, cicada carrot (participant) extract, mangosteen extract, ginger extract, melaleuca extract, yachabushi extract, himeya shabushi Extract, Oobaya Shabushi Extract, Yakumosou Extract, Yamahanoki (Yamatake) Extract, Longan (Yongan) Extract, Locon (Yoshi, Sone) Extract, Logwood Extract, Lantana Extract, Phthalazinones, Benzoxazinones, Phosphonic Acid Derivatives , Cyproterone, 5α-androstene- 3α, 17β-diol, medroxyprogesterone, norethisterone, mestanolone, ichihatsu (primary) extract, katsu extract, kanto extract, sanjiko extract, shiramo extract, prunus extract, scabbard licorice extract, fritillary extract, cypress extract, seaweed extract, Yoremoku extract.

(25) Odor-eliminating agent: Inond extract, Elemi extract, Danmar extract, vanilla bins extract, pine extract and the like.

  The ingredients derived from plant-based materials used as additives include Aokazura (Seifu Fuji) extract, Aotenma extract, Akasuguri extract, Akinire (crust) extract, Aguay guassu extract, Abiyu extract, Abiurana extract, Yellow support extract , Ylang ylang extract, phalaenopsis extract, uba tea extract, suzuran extract, unboku extract, elderberry extract, sasayukiyuki extract, sasanoyuki extract, tossed cactus extract, ohia catechu extract, onoelan extract, crab extract , Karaya extract, Garyu extract, Kawaratake extract, Candelilla extract, Canna extract, Kidachi pepper extract, Kimenka extract, cabbage extract, Kiraja saponaria extract, Ginseng extract, Kimbusen extract, Guape・ Vermela Extract, Kugenuma Maran Extract, Coosberry Extract, Cutty River Extract, Curkurigo Latifolia Extract, Black Ganechi (rescue) Extract, Kouliang Extract, Sapotea Marillo Extract, Salmon Berry Extract, Salamander ) Extract, Cactus Cactus Extract, Cinnamon Extract, Shunlan Extract, Shozuk Extract, Shirobanatsuta Extract, Cinchona Sacylbra Extract, Swimberry Extract, Star Apple Extract, Sulgaran (Oran) Extract, Scots Pine Extract, Scots Tree Extract, Seiyo Japanese butterfly extract, mistletoe extract, sennin cactus extract, senboku extract, elephant weevil extract, cinnamon extract, some mono-potato extract, dark sweet cherry extract , Prickly pear extract, Choco nostay extract, Korean mugwort extract, Azalea extract, Azalea extract, Azalea extract (Duckweed) extract, Duberry extract, Papaver extract, Tragacanth extract, Triacanthus extract, Neiseria berry Extract, rapeseed extract, physalis extract, paw doce extract, hakukayumatou extract, hakuberry berry, batata extract, oysters extract, balata extract, hulcan orchid extract, pecan nut extract, chickweed extract, himomeooran extract, Brazilian carrot extract, Branjen extract, Fruceria extract, Blond psyllium extract, Hetsukaran extract, Henken extract, Berry extract, Persea extract, Pervianburg extract, Pereschia gran Ifolia extract, Boysenberry extract, Hosairan extract, Pouteria sapota extract, Pouteria rukuma extract, Hosobabarengiku extract, Whataberry berry extract, Masalan basoba extract, Masala nuba de cereal extract, Masheira de Boi extract, Matta・ Auryo extract, Mulberry extract, Green potato extract, Purple corn extract, Megacansa opuntica extract, Mokukirin extract, Japanese maple extract, Morero cherry extract, Yakawa purple extract, Cornflower extract, Ruritama thistle Indigo sashimi) extract, red currant extract, red pitaya extract, lemongrass extract, wax palm extract, logan berry extract and other plant extracts.

  Ingredients derived from plant-based materials used as additives include Dunaliella genus Dunaliella extract, Chlorococcus chlorococcus extract, Kuwanomimo genus mulberry extract, Volbox genus genus extract, Volbox genus Volbox extract, Palmera extract, Yotsumemo extract, Aomido genus Zoriori extract , Tsurugidomiro extract, Hibidomylo spp. Black Ivy extract, Casanori genus Casanori extract, Mika Ichiki extract, Collecaete extract, Tsutsumi Mimo extract, Perennial genus Duckweed extract, Sayamidro extract, Green algae extract such as Japanese pepper extract, Sumiremo violet extract, Hosimidro extract, Fuchinashimidoru extract, Cyanobacteria genus Suizendinori extract, Blue-green algae extract such as Blue-green extract, Yulemo extract, Piraera genus Piraela extract, Shiomidomo genus Nagamisiomidro extract, Isovine genus Iso Grape extract, Isogawara genus Isogawara extract, Black moth genus Black moth moth extract, Casilla genus Kashirazaki extract, Muchimo genus Muchimo extract, Muchimo genus Hiramchimo extract, Muchimo genus Quercus crisposa extract, Amygusa genus Sakibiro amiji extract, Common genus Common genus extract, Jigamigusa genus Jigmygusa extract, Nami-makura genus Hirami-makura extract, Someraceae genus Someraceae extract, Navaimo genus Navarimo extract, Chasomen genus Motsuki-chisoume Extract , Crested genus Extract, Crested genus, Common crested genus Common extract, Common crested genus Ezobukuro extract, Crested genus Crested genus Extract, Caryaceae Crested genus Extract, Blossomus genus Extract, Shark Crested shark Yokojimanori extract, genus Cyprus genus extract, genus genus genus extract, vine genus turmeric extract, genus chromae Brown algae extracts such as kiss, chrysanthemum genus chrysanthemum extract, nerecomb genus extract, brown spruce burdock extract, cabbage genus extract, etc. Amanori Tasa Extract, Amanori Phyritasa Extract, Amanori Benitasa Extract, Rhodocorton Milnobeni Extract, Kona Hada Hyakona Hada Extract, Kona Hada Yokore Kona Hada Extract, Kona Hada Ao Kona Hada Ex Extract, pine genus pine extract, nisefusanori genus fusanori extract, sodegarami genus sodagarami extract, hirohata maki genus hirohata maitake extract, amanita nambugusa Kisses, Tengusa spp. Extract Coral coral extract, Centacum spruce extract, Centacum Hiramkade extract, Centacum spp extract, Centacum spp. Centipede extract, Centipede spruce extract, Centipede spruce extract, Centipede spp. Kintoki genus Pinus extract, Kintoki fushikintoki extract, Kintoki tsunomukade extract, Kintoki nagakintoki extract, Kintoki spruce cadaver extract, Kakiteto Obakintoki extract, Nagaobane spp. Tuscanula genus Karimenia extract, Tsukasanori Otsukasanori extract, Tsukasanori Hanagakarimenia extract, Honooka genus Hono Extracts Isodantsu extract, Atsubanori genus Azobanori extract, Ogonori spp. Ogonori Katagonori Extract, Ogonori Ryukyu Ogonori Extract, Ogonori Ogonori Extract, Ogonori Ittsuginu Extract, Ogonori Yumigataogonori Extract, Ogonori genus Chibiriogonori extract, Ogonori genus Mosaogonori extract, Ogonori genus Fusarium extract, Fushikenori genus Fukukurenori extract, Namiiwatake namiiwatake extract, Saimi genus Thymus extract, Sami genus extract, Lotus Black-headed ginseng extract, Cyprinus genus Hachibukuro extract, Madaragusa genus extract, Madaragusa Etsukimadara extract, Taoyagi Taoagisou extract, Taoyagi genus Hanakusa extract, Fukutsunagi genus Fukutsunagi Hananoeda extract, Hiraota goat genus Hirata goat extract, Darus genus Masagoshi Bali extract, Darus genus Anadalus extract, Weavusa genus Weibusa extract, Bee Fuchunori spp. Extract, Suzushironori Extract, Usbeni Genus Usbeni Extract, Hasujiginu Hasujiginu Extract, Nagakonono Hanori Nagakonohanori Extract, Sugiginus Sugiginu Extract, Sugiginus Atsubasuginu Extract, Hius Banori Genius Cageus Banori Extract, Haius Banori Genius Heusius Bavaria Usubanori Extract, Haiusubanori Hiusubanori Extract, Usubanorimodokiu Usubanorimodoki Extract, Ayanishiki Ayanishiki Extract, Ayaginu Ginnu Extract, Dadia Enasidadia Extract, Shimadadia Isohagi Extract, Shimadadia Shimadadia Extract, Dajimodoki Daijimodoki Extract, Makuri Genome Extract, Hanegusa Hanegusa Extract, Hanegusa Kehanegusa Extract, Kozanemo Cozaemone Extract Chrysanthemum extract, Himego-genus Himego-keki extract, Himego-keki-Kuro-himegome extract, Hyodosigki chrysanthemum extract, Hyodosigus hyodosigusa extract, Hyodosigus genus Usobahiodosi extract, Isomegusa isomegusa extract, Suzynagusa spp. Red algae extracts such as genus Isobasho extract, Ideukogome genus Yukogome extract, Ochimomoku Okichimozuku extract, Chisujinori genus Chisujinori extract, Axillary extracts such as Dicumulus extract, Shiratamamo extract, Hoshitsurimo Hoshitsurimo extract, Likunnotumusu extract, Flamingo spruce extract, Chaboflask extract, Tripera extract, etc. Yellow algae extract such as Hikarimo spp.

  Examples of ingredients derived from animal materials used as active ingredients or additives include chicken crown extract, cow, pig or human placenta extract, pig or cow stomach, duodenum, intestine, spleen extract or decomposition products thereof, cow or pig Brain tissue extract, water-soluble collagen, collagen derivatives such as acylated collagen, collagen hydrolyzate, elastin, elastin hydrolyzate, water-soluble elastin derivative, keratin and its degradation product or derivatives thereof, silk protein and its degradation product Or derivatives thereof, porcine or bovine blood cell protein degradation product (globin peptide), cattle or porcine hemoglobin degradation product (hemin, hematin, heme, protoheme, heme iron, etc.), milk, casein and degradation products thereof or derivatives thereof Skim milk powder and its degradation products or derivatives thereof, lactoferrin or its degradation products, egg component, fish degradation , Nucleic acid-related substance (ribonucleic acid, deoxyribonucleic acid), and the like.

  Examples of components derived from microbial materials used as active ingredients or additives include yeast metabolites, yeast extract, bacterial metabolites, bacterial extracts, metabolites such as mold or mushroom, actinomycetes metabolites, mold or mushroom Extract, Actinomyces extract, Natto metabolite, Natto extract, Rice fermented extract, Rice bran (red rice bran, white birch) fermented extract, Euglena extract or its degradation products or their water-soluble derivatives, lactic acid fermentation of raw milk or skim milk powder Products, trehalose or derivatives thereof.

  In addition, as a plant, animal, or microbial material, any site, cell, tissue, organ, metabolite, etc. derived from a transgenic body or a cell fusion can be used. Furthermore, it is obtained by culturing cells of any site, cell, tissue, organ, etc., for example, cultured cells derived from each tissue (cultures derived from animals such as fibroblasts, Langerhans cells, macrophages, epidermal cells, hepatocytes, etc.) Cell etc.), undifferentiated cell group, cell group in the middle of differentiation, and their metabolites can also be used.

  As natural ingredients used as active ingredients or additives, seawater such as deep sea water, for example, sea salt, seawater dried product, inorganic salt obtained from the Dead Sea or Atlantic Ocean or Pacific Ocean (sodium chloride, magnesium chloride, chloride) Potassium etc.), sea mud or mud (Fango), for example, Italian mud, German fungo, Eifel Fango, Freiburg fungo, etc. Sea mud or mud (containing components: silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, Manganese oxide, sodium oxide, potassium oxide, magnesium oxide, calcium oxide, strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic, water), marine such as saintoku stone Ingredients etc.

  Extracts derived from plant-based raw materials, animal-based raw materials, microbial-based raw materials, and other natural product raw materials used as active ingredients or additives are processed in a conventional manner according to the product type and form to be added (for example, pulverized) , Milling, washing, extraction, degradation, fermentation or metabolic conversion by microorganisms, fractionation, purification, pressing, filtration, drying, powdering, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc. It is only necessary to select and use any of various materials.

  The solvent used for extraction may be selected in consideration of the intended purpose and type of the product to be provided or the processing to be performed later. Usually, water, methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol, isopropanol are used. Lower alcohol such as butanol or hydrous lower alcohol, propylene glycol, 1,3-butylene glycol, 1,2-butylene glycol, 1,4-butylene glycol, 1,5-pentanediol, 1,2-pentanediol, 1, Polyhydric alcohols such as 3-pentanediol, 1,4-pentanediol, 1,3,5-pentanetriol, glycerin, polyethylene glycol (molecular weight 100 to 100,000) or water-containing polyhydric alcohols, acetone, ethyl acetate, diethyl ether , Dimethyl ether, ethyl methyl ether, dioxane, acetonitrile, Various organic solvents such as silene, benzene, chloroform, carbon tetrachloride, phenol, toluene, etc., acids (hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, formic acid, acetic acid, etc.) and alkalis (sodium hydroxide, water, etc.) prepared as appropriate. It is desirable to use one or a mixture of two or more selected from potassium oxide, calcium hydroxide, ammonia and the like. However, when it is not preferable to contain a solvent depending on the application, it is sufficient to use only water or ethanol that can be easily removed after extraction, and it can be used alone or in any mixture with water. What was extracted may be sufficient.

  Regarding the extraction method, the temperature of the solvent, the weight ratio of the solvent to the raw material, or the extraction time can be arbitrarily set for various raw materials and the solvent used. Although it can set arbitrarily as the temperature of a solvent in the range of -4 degreeC to 100 degreeC, 10-40 degreeC vicinity is preferable from the point of stability of the component contained in a raw material. Also, the weight ratio of the solvent to the raw material can be arbitrarily set, for example, within the range of the raw material: solvent 4: 1 to 1: 200, and the weight ratio of 1: 1 to 1:10 is particularly preferable.

  Decomposition mainly includes acid decomposition, alkali decomposition, enzyme decomposition, and high-temperature and high-pressure decomposition. In the decomposition with an acid, for example, it is preferable to use an inorganic acid or an organic acid such as hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, acetic acid, formic acid, oxalic acid, hydrogen bromide, perchloric acid, and periodic acid. In the decomposition by alkali, for example, sodium hydroxide, potassium hydroxide, calcium hydroxide, ammonium hydroxide, barium hydroxide, sodium carbonate, ammonium carbonate, calcium carbonate, magnesium hydroxide, sodium silicate, etc. are preferably used. In the decomposition with acid or alkali, the concentration, reaction time, reaction temperature, and the like can be arbitrarily set for the target raw material. In the enzymatic degradation, it is preferable to use an enzyme having a function of degrading proteins, polysaccharides, lipids or complexes thereof having an important function particularly with respect to cell structure, tissue structure, etc., for example, aminopeptidase, dipeptidase, dipeptide Peptidyl peptidase, tripeptidyl peptidase, carboxypeptidase, serine protease, trypsin, chymotrypsin, cysteine protease, thiol protease, papain, aspartate endopeptidase, metalloendopeptidase, promeline, thermolysin, pronase, pepsin, rennin, Proteolytic enzymes (proteases) such as pancreatin, chymopapain, ficin, collagenase, elastase, amylase, takaamylase, cellulase, hemicellular Polysaccharide-degrading enzymes such as zectin, pectinase, polygalacturonase, dextranase, and pralanase, chicken egg white lysozyme, human lysozyme, papaya lysozyme, cabra lysozyme, barley lysozyme, zymolyce, lysozyme chloride, glucanase, gluco Examples include cell wall lytic enzymes such as uronidase, chitinase, and kilosanase. In the case of using an enzyme, the concentration, reaction time, reaction temperature, pH of the solution, and the like can be arbitrarily set, but it is particularly preferable to set the optimum value for the enzyme used.

Fermentation or metabolic conversion by microorganisms can be carried out by inoculating and growing at least one or more microorganisms on a raw material used as a substrate. Inoculation of microorganisms to the substrate can be done by adding microorganisms directly into the substrate, or by adsorbing them on a carrier such as alginic acid, polyvinyl, gelatin, etc., for example, in the form of fine beads composed of microorganisms and carrier. Further, it can be used by being fixed to the tube wall of the bioreactor. Fermentation or metabolic conversion by microorganisms is not particularly defined as a microorganism to be used, but can generally be defined as microorganisms other than pathogenic microorganisms that exhibit significant toxicity to living bodies. Examples of microorganisms to be used include microorganisms classified into yeasts: Aciculoconidium, Actonia, Aessosporon, Ambrosiozyma, Amphierna, Anthomyces, Apiotrichum, Arthroascus, Arxula, Ascotrichosporon, Ashbia, Ashbya Genus, Asporomyces, Atelosaccharomyces, Azymocandida, Azymohansenula, Azymomyces, Azymoprocandida, Babjevia, Ballistosporomyces, Basidiotrichosporon, Bensingtonia, Blastobotrysbota, Blastodlastrzo Brettanomyces (Brettanomyces bruxellensis, Brettanomyces anomalus, etc.), Bullera, Bulleromyces, Candida (Candida albicans, Candida amylolenta, Candida anomala, Candida boidinii, Candida entomaea, Candida etchellsment, Candida etchellsii, Candida etchellsment Candida intermedia, Candida krusei, Candida lactosa, Candida lipolytica, Candida mogii, Candida parapsilosis, Candida sake, Candida tropicalis, Candida versatilis, Candida vulgaris, etc., Castellania, Chlamydozyma, Chromotorula, Citeromyces, Cladosporium, Clavispora, Crebrothecium, delbaryo, genus halotolerans, Debaryomyces hansenii, etc.), Debaryozyma, Dekkera, Dekkeromyces, Dematium, Dipodascus, Eeniella, Enantiothamnus, Endoblastoderma, Endoblastomyces, Endomyces, Endomycopsis, Endyllium, Etelexium, Entelex Genus, Eutorula, Eutorulopsis, Fabospora, Fellomyces, Fermentotrichon, Filobasidium, Galactomyces, Geotrichoides, Geotrichum, Guilliermondella, Hanseniaspora, Hansenulaan, Hansenulaan, Hansenulaan, Hansenula Hansenula wickerhamii), Hypomyces, Issatchenkia, Kloeckera (Kloeckera brevis, Klo) eckera fluorescens, Kloeckera japonica, etc.), Kloeckeraspora, Kluyveromyces (Kluyveromyces bulgaricus, Kluyveromyces marxianus, Kluyveromyces thermotolerans, Genus Kockovaella, Kurtzmanomyces, Leucosporidium, Leucosporidium, Leucosporidium Monospora, Monosporella, Mrakia, Myceloblastanon, Mycocandida, Mycoderma, Mycotorula, Mycokluyveria, Mycotoruloides, Myxozyma, Nadsonia, Nectaromyces, Nematospora, Otosporomyces, Ogataea, Ogataea , Oosporidium genus, Pachysolen genus, Parasaccharomyces genus, Paratorulopsis genus, Parendomyces genus, Petasosospora genus, Pichia genus (genus Pichia amylophila, Pichia farinosa, Pichia guilliermondii, Pichia membranifaciens, Pichia mogirum, genus Proticcpo Proteomyces, Pseudohansenula, Pseudomonilia, Pseudomycoderma, Pseudosaccharomyces , Pseudozyma spp, Rhodomyces genus, Rhodosporidium genus, Rhodotorula genus, Saccharomyces genus (Saccharomyces aceti, Saccharomyces cerasi, Saccharomyces cerevisiae, Saccharomyces exiguus, Saccharomyces unisporus, Saccharomyces fibuligera etc.), Saccharomycodes genus, Saccharomycopsis spp, Saturnispora genus, Schizoblastosporion spp, Schizosaccharomyces spp , Schwanniomyces genus, Selenotila genus, Selenozyma genus, Smithiozyma genus, Sporidiobolus sp Genus, Vanrija, Waltomyces, Willia, Willopsis, Wingea, Xanthophyllomyces, Yamadazyma, Zendera, Zygofabospora, Zygopichia, Zygohansenula, Zygorenospora, Zygosaccharomyces, Zygosaccharomyces, etc. . Microorganisms classified as bacteria include Acetobacter genus (Acetobacter aceti, etc.), Achromobacter genus, Acidianus genus, Acidobacterium genus, Acidithiobacillus genus, Acrocarpospora genus, Actinoalloteichus genus, Actinocorallia genus, Actinokineospora genus, Actinomadspura genus, Actinomadspura Actinosynnema genus, Aerococcus genus, Aeromicrobium genus, Agrobacterium genus, Agromyces genus, Ahrensia genus, Alcaligenes genus, Alicyclobacillus genus, Alloiococcus spp. , Aureobacterium genus, Azotobacter genus, Bacillus genus (Bacillus brevis, Bacillus subtilis etc.), Bacteroides genus, Beneckea genus, Bifidobacterium genus (Bifidobacterium bifidum, Bifidobacterium longum, Bifidobacterium breve, Bifidobacterium infantis etc.), Brachybacterium genus, Brevicillus, Brevundimonas, Burkholderia, Carnobacterium, Catellat genus ospora, Cellulomonas, Chainia, Chromobacterium, Chryseobacterium, Citrobacter, Clavibacter, Corynebacterium, Couchioplanes, Cryptosporangium, Curtobacterium, Dactylosporangium, Deinococcus, Delftia, Dermatia, Dermatia , Elytrosporangium, Enterobacter, Erwinia, Escherichia, Eubacterium, Excellospora, Exiguobacterium, Faenia, Flammeovirga, Flavobacterium, Flexibacter, Geodermatophilus, Globicatella, Gluconacetobaceto, Gluconacetobacter Genus, Gordonia, Halobacterium, Halococcus, Herbidospora, Hydrogenophilus, Hyphomicrobium, Hyphomonas, Intrasporangium, Janibacter, Jonesia, Kibdelosporangium, Kineopocusato, Kitasposatos, Kitasposatos, Kitasposatos Klebsiella, Kocuria, Kurthia, Lactobacillus (Lactobacillus rimae, Lactobacillus dive rgens, Lactobacillus carnis, Lactobacillus piscicola, Lactobacillus acidophilus, Lactobacillus amylophilus, Lactobacillus animalis, Lactobacillus brevis, Lactobacillus casei, Lactobacillus curvatus, Lactobacillus bulgaricus, Lactobacillus delbrueckii, Lactobacillus fermentum, Lactobacillus fructivorans, Lactobacillus fructosus, Lactobacillus helveticus, Lactobacillus hilgardii, Lactobacillus homohiochii, Lactobacillus kefiri, Lactobacillus malefermentans, Lactobacillus murinus, Lactobacillus paracasei, Lactobacillus paracasei subsp. tolerans, Lactobacillus parakefiri, Lactobacillus pentosus, Lactobacillus plantarum, Lactobacillus reuteri, Lactobacillus rhamnosus, Lactobacillus sakei, Lactobacillus confusus, Lactobacillus viridescens, Lactobacillus johnsonii, Lactobacillus viscosus, Lactobacillus bunchneri , Lactobacillus fermentatae, Lactobacillus acidophil-aerogenes, Lactobacillus leichmannii, Lactobacillus gasseri, Lactobacillus bifidus, Lactobaci llus jugurt, Lactobacillus caucasicus, Lactobacillus arabinosus, Lactobacillus kunkeei, Lactobacillus nagelii, Lactobacillus fornicalis, Lactobacillus pentoaceticus, Lactobacillus xylosus, Lactobacillus minutus, etc.), Leuconostoc genus (Leuconostoc lactis, Leuconostoc dextranicum, Leuconostoc mesenteroides, Leuconostoc oenos, Leuconostoc paramesenteroides, Leuconostoc cremoris, Leuconostoc citrovorum etc.), Listonella genus, Lucibacterium genus, Luteococcus genus, Magnetospirillum genus, Marinilabilia genus, Marinospirillum spp. Genus, Nocardioides, Nonmuraea, Nonomuria, Oceanospirillum, Ochrobactrum, Oerskovia, Oligella, Paenibacillus, Pediococcus ui, etc.), Pedobacter, Peptococcus, Peptostreptococcus, Pilimelia, Pimelobacter, Planobispora, Planococcus, Planomonospora, Prevotella, Propionibacterium, Proteus, Protomonas, Pseudomonas, Genus, Rathayibacter, Rhizobium, Rhizomonas, Rhodobacter, Rhodococcus, Rhodopseudomonas, Rhodospirillum, Rothia, Rubrobacter, Ruegeria, Saccharomonospora, Siracrothinas, Sporolactobacillus spp., Stenotrophomonas spp., Streptoalloteichus spp., Streptococcus spp. (Streptococcus durans, Streptococcus faecalis, Streptococcus faecium, Streptococcus bovis, Streptococcus equinus, Streptococcus mutans, Streptococcus salivarius, Streptococcus thermophilus, Streptococcus agalactiae, Streptococcus mitis, Streptococcus pyogenes, Streptococcus pneumoniae, Streptococcus lactis , Streptococcus dysgalactiae, Streptococcus sanguis, Streptococcus acidominimus, Streptococcus avium, Streptococcus uberis, Streptococcus cremoris, Streptococcus diacetilactis, etc. Genus, Thiobacillus genus, Thiomonas genus, Thiosphaera genus, Weissella genus, Xanthobacter genus, Xanthomonas genus, Zymomonas genus and the like. Microorganisms classified as ascomycetes, basidiomycetes or incomplete fungi other than yeast include Allomyces, Amoebidium, Amorphotheca, Arthroderma, Ascoidea, Ascobolus, Ascodesmis, Aspergillus, Aureobasidium, Botryosphaeria , Botryotinia, Brachybasidium, Byssochlamys, Capnodium, Ceratocystis, Ceratomyces, Chaetomium, Chrysella, Chrysocelia, Chytridium, Claviceps, Cochliobolus, Coemansia, Genus Genus, Cyttaria, Dasyspora, Derchslera, Dirchmyces, Dichomyces, Dothidea, Endogone, Entomophthora, Emericella, Eupenicillium, Eurotium, Exobasidium, Gibberella, Glomus, Graphiola, Gymnoascus, Harpella Helicomyces, Hellvella, Hemicarpenteles, Hyphochytrium, Hypocrea, Laboulbenia, Labyrinthula, Leptosphaeria, Leptosphaerulina, Lophodermium, Melanotaenium , Microascus, Microstroma, Medeolaria, Melampsora, Melampsporella, Morchella, Monascus, Monilinia, Monoblephalis, Mycospharella, Nannizzia, Nectria, Neolecta, Neurospora, Nodulosphaeria, Olizadium, Genus, Penicillium, Perenospora, Pestalotiopsis, Phomopsis, Phragmi
diella genus, Pneumocystis genus, Preussia genus, Pleospora genus, Puccinia genus, Pythium genus, Ravenelia genus, Rickia genus, Rhinocladiella genus, Rhizidiomyces genus, Rhizoctonia spp. Sordaria genus, Sporidiobolus genus, Stibella genus, Stigmatomyces genus, Sydowiella genus, Talaromayces genus, Taphrina genus, Thraustochytrium genus, Tolyposporium genus, Trichoglossum genus, Trichoma genus, Ustilago genus, Verticillium genus, Xylaria genus and the like.

  In fermentation or metabolic conversion by microorganisms, in addition to various raw materials such as plant-based materials, animal-based materials, and other natural product-based materials, the growth and metabolism of microorganisms are regulated or activated, and special biosynthesis or degradation pathways are induced. In order to achieve this, various compounds can be added to the raw material. For example, as a carbon source, a sugar or ethane such as glucose, fructose, galactose, sucrose, maltose, mannose, lactose, glycerol, starch, etc. , Hydrocarbons such as methane, propane, butane, formic acid, acetic acid, propionic acid, lauric acid, palmitic acid, fatty acids such as oleic acid, linoleic acid, linolenic acid, etc., nitrogen sources such as ammonium sulfate, ammonium hydrochloride, ammonium phosphate, etc. Ammonium salt, urea, uric acid, amino acids, etc. Vitamins and compounds that contain potassium, calcium, magnesium, sodium, sulfur, phosphorus, chlorine, etc., as well as iron, copper, zinc, cobalt, nickel, boron, manganese, molybdenum, tin, selenium, silicon It is possible to further add compounds contained in the composition such as arsenic, vanadium, chromium and fluorine. In addition, the optimum temperature, oxygen supply amount, pH, pressure, etc. that affect the growth and metabolic activity of various microorganisms can be arbitrarily set according to the characteristics inherent to various microorganisms. Can be arbitrarily set in the range of 10 to 50 ° C., and the pH can be arbitrarily set in the range of 1 to 14.

  In fractionation or purification, generally known techniques can be used as appropriate. In addition to solvent extraction, for example, liquid chromatography (ion exchange chromatography, ion exclusion chromatography, affinity chromatography, gel filtration chromatography, size exclusion chromatography, etc.). Chromatography, hydrophilic adsorption chromatography, hydrophobic adsorption chromatography, ligand exchange chromatography, etc.), dialysis with semipermeable membrane, crystallization and recrystallization of components, filter paper, membrane filter, ultra filter, Examples thereof include filtration using activated carbon, a filter aid, and the like, centrifugal separation, and fractional precipitation, which is an application thereof, and density gradient separation methods such as a red zone centrifugal separation method and a density gradient sedimentation equilibrium method.

  In the present invention, other compounds used as additives include silicic anhydride, magnesium silicate, talc, kaolin, bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide, titanium oxide, calcium carbonate, Inorganic pigments such as magnesium carbonate, yellow iron oxide, bengara, black iron oxide, gunjou, chromium oxide, chromium hydroxide, carbon black, calamine, hydrogen peroxide, sodium persulfate, ammonium persulfate, sodium perborate, peroxy Urea oxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, sodium pyrophosphate, sodium orthophosphate, sodium silicate hydrogen peroxide adduct, sodium sulfate hydrogen peroxide adduct, Sodium chloride Hydrogen oxide adduct, β-tyrosinase enzyme solution, mushroom extract, strontium sulfate, sodium sulfide, barium sulfide, calcium sulfide and other inorganic reducing agents, thioglycolic acid or its salts (calcium thioglycolate, sodium thioglycolate, Redox agents such as lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate), 5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4 -Methylaminoanthraquinone, 3,3'-iminodiphenol, 2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, salt Metaphenylenediamine, orthoaminophenol, acetic acid N-phenylparaphenylenediamine, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4 -Diamine, nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol, picramic acid, sodium picrate, N, N'-bis (4-aminophenyl) -2,5- Diamino-1,4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenylparaphenylenediamine, metaaminophenol, metaphenylenediamine, 5-aminoorthocresol sulfate, 2-amino-sulfate 5-nitrophenol, ortho-aminophenol sulfate, ortho sulfate Lorparaphenylenediamine, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene-2,5-diamine sulfate, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, parasulfate sulfate Nitrometaphenylenediamine, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate, catechol, diphenylamine, α-naphthol, hydroquinone, phloroglucin, 2-hydroxy-5-nitro-2 ', 4 ′ -Diaminoazobenzene-5′-sulphonate, dyes such as hematein, natural animal flavors such as musk, civet, castrium, ambergris, anise essential oil, angelica essential oil, ylang ylang essential oil, iris essential oil, cormorant Kyo essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, guayakwood essential oil, cumin essential oil, black letter essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil , Jasmine essential oil, gingergrass essential oil, cedar essential oil, spearmint essential oil, Western peppermint essential oil, Otsuka perfume essential oil, tuberose essential oil, dichroic essential oil, orange flower essential oil, winter green essential oil, troubalsum essential oil, rose essential oil, rose essential oil, palmarosa essential oil, salmon Essential oil, Hiba essential oil, sandalwood essential oil, petit gren essential oil, bay essential oil, vetiva essential oil, bergamot essential oil, peru balsam essential oil, boadrose essential oil, mellow essential oil, mandarin essential oil, eucalyptus essential oil, lime essential oil, lavender essential oil, linaloe essential oil, lemongrass Oil, lemon essential oil, rosemary essential oil, vegetable flavors such as Japanese mint essential oil, other synthetic flavors, 5-amino-o-cresol, o-aminophenol, m-aminophenol, p-aminophenol, 2 , 6-Diaminopyridine, 5- (2-hydroxylethylamino) -2-methylphenol, N, N-bis (β-hydroxyl) -p-phenylenediamine sulfate, N, N-bis (2-hydroxyethyl) ) -p-phenylenediamine, p-nitro-o-phenylenediamine, p-phenylenediamine, m-phenylenediamine, N-phenyl-p-phenylenediamine, 2-hydroxy-5-nitro-2 ', 4'-diamino Azobenzene / sodium sulfate, toluene-2,5-diamine, 2- (2'-hydroxyethylamino) -5-aminotoluene, N, N-bis (β-hydroxyl) -p-phenylenediamine, N, N-bis (2-hydroxyethyl) -p-phenylenediamine sulfate 5-amino-o-cresol sulfate, p-aminophenol sulfate, o-chloro-p-phenylenediamine sulfate, 2- (2'-hydroxyethylamino) -5-aminotoluene sulfate, 4,4'-diaminodiphenylamine / sulfate, p-methylaminophenol / sulfate, p-phenylenediamine / sulfate, m-phenylenediamine / sulfate, toluene-2,5-diamine / sulfate, 2,4 -Diaminophenoxyethanol / hydrochloride, toluene-2,5-diamine / hydrochloride, m-phenylenediamine / hydrochloride, 2,4-diaminophenol / hydrochloride, 3,3'-iminodiphenol, p-phenylenediamine Hydrochloride, N-phenyl-p-phenylenediamine / hydrochloride, N-phenyl-p-phenylenediamine / acetate, 1,5-dihydroxynaphthalene, toluene-3,4-diamine, p-methylaminophenol, N, N'-bis (4-aminophenyl) -2,5 -Diamino-1,4-quinonediimine, o-aminophenol sulfate, 2,4-diaminophenol sulfate, m-aminophenol sulfate, 2-amino-4-nitrophenol, 2-amino-5- Nitrophenol, 1-amino-4-methylaminoanthraquinone, nitro-p-phenylenediamine hydrochloride, 1,4-diaminoanthraquinone, nitro-p-phenylenediamine, picramic acid, sodium picrate, 2-amino-5- Nitrophenol / sulfate, resorcinol, nitro-p-phenylenediamine / sulfate, p-nitro-o-phenylenediamine / sulfate, p-nitro-m-phenylenediamine / sulfate, red No. 2, red No. 3, Red No. 102, Red No. 104 (1), Red No. 105 (1), Red No. 106, Red No. 201, Red No. 227, Red No. 230 (1), Red No. 230 (2), Red 231 No., Red 23 No., Red 401, Red 502, Red 503, Red 504, Red 506, Yellow 4, Yellow 5, Yellow 202 (1), Yellow 202 (2), Yellow 203, Yellow 402, Yellow 403 (1), Yellow 406, Yellow 407, Orange 205, Orange 207, Orange 402, Green 3, Green 204, Green 205, Green 401, Green 402 No., Brown No. 201, Purple No. 401, Blue No. 1, Blue No. 2, Blue No. 202, Blue No. 203, Blue No. 205, Black No. 401, Red Cabbage Dye, Red Rice Dye, Akane Dye, Anato Dye, Ikasumi Dye , Turmeric, enju, krill, amber, caramel, gold, silver, gardenia, corn, onion, tamarind, spirulina, buckwheat, cherry, nori, hibi Cass pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin and other pigments and colorants, avocado oil, almond oil, fennel oil, egoma oil, olive oil, orange oil, orange rafa oil , Sesame oil, cacao butter, chamomile oil, carrot oil, cucumber oil, beef tallow fatty acid, kukui nut oil, safflower oil, shea fat, liquid shea fat, soybean oil, camellia oil, corn oil, rapeseed oil, persic oil, castor oil, Fats and oils such as cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, palm oil, palm kernel oil, owl, coconut oil, beef tallow, lard, and hydrogenated products (hardened oil etc.) of these oils, beeswax, Carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax, montan wax, shellac Waxes such as wax, rice wax, squalene, squalane, pristane, mineral oils such as liquid paraffin, petrolatum, paraffin, ozokelide, ceresin, microcristan wax, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, olein Natural fatty acids such as acid, linoleic acid, linolenic acid, docosahexaenoic acid, eicosapentaenoic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, lanolin fatty acid, isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2- Fatty acids such as methylpentanoic acid, 2-ethylhexanoic acid, isopentanoic acid and other synthetic fatty acids, ethanol, isopyropanol, lauryl alcohol, cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol , Phytosterols, natural alcohols such as phenoxyethanol, alcohols such as 2-hexyldecanol, isostearyl alcohol, synthetic alcohols such as 2-octyldodecanol, isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristic acid Myristyl, oleyl oleate, decyl oleate, octyldodecyl myristate, hexyldecyl dimethyloctanoate, diisobutyl adipate, 2-hexyldecyl adipate, diheptylundecyl adipate, N-alkylglycol monoisostearate, isocetyl isostearate, Trimethylolpropane triisostearate, ethylene glycol diethylhexanoate, neopentyl glycol diethylhexanoate, 2-ethylene Cetyl ruhexanoate, trimethylolpropane triethylhexanoate, pentaerythritol tetraethylhexanoate, cetyl octanoate, octyldodecyl gum, cetyl lactate, myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, monostearate Esters such as propylene glycol acid and propylene glycol dioleate, metal soaps such as aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate and zinc undecylenate, anions Surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate ester salt, alkyl phosphate ester salt), cation Surfactant (alkylamine salt, alkyl quaternary ammonium salt), amphoteric surfactant: carboxylic acid type amphoteric surfactant (amino type, betaine type), sulfate ester type amphoteric surfactant, sulfonic acid type amphoteric surfactant , Phosphate ester type amphoteric surfactant, nonionic surfactant (ether type nonionic surfactant, ether ester type nonionic surfactant, ester type nonionic surfactant, block polymer type nonionic surfactant, Nitrogen-containing nonionic surfactants), other surfactants (natural surfactants, derivatives of protein hydrolysates, polymer surfactants, surfactants containing titanium / silicon, fluorocarbon surfactants) ) And the like.

  In addition, hormones, sequestering agents, pH adjusters, chelating agents, antiseptic / antibacterial agents, refreshing agents, stabilizers, emulsifiers, animal / plant proteins and their degradation products, animal / plant polysaccharides and their Degradation products, animal / plant glycoproteins and their degradation products, anti-inflammatory agents, antiallergic agents, wound treatment agents, foaming agents, thickeners, enzymes, purified water (electronic water, small clusters, etc.), deodorant / A deodorant etc. can be used in combination.

[Production example]
Hereinafter, the present invention will be described in more detail with reference to production examples.

(Production Example 1)
Using a steam distillation apparatus, steam distillation of 2 kg of dried neem leaves was performed. The obtained residue was immersed in 10 times the amount of 50% 1,3-butylene glycol, extracted for one week at room temperature, and then filtered to obtain 18 kg of an extract (dry solid content: about 0.8%).

(Production Example 2)
Using a steam distillation apparatus, steam distillation of 2 kg of dried neem leaves was performed. The obtained residue was immersed in a 10-fold amount of 30% ethanol solution, extracted at room temperature for 7 days and nights, and then filtered to obtain 17 kg of an extract (dry solid content: about 0.9%).

(Production Example 3)
Using a steam distillation apparatus, steam distillation of 2 kg of dried neem leaves was performed. The obtained residue was immersed in 10 times the amount of purified water (about 20 ° C.), extracted at room temperature for 5 days, and then filtered to obtain 18 kg of an extract (dry solid content: about 0.6%).

[Test 1] Skin sensitization test (sample)
The neem leaf extract of Example 1 was used for the test. As a comparative control, a neem leaf extract (comparative example) obtained by extraction with a 50% 1,3-butylene glycol solution from neem leaves that had not been subjected to steam distillation in advance, which was a conventional extraction method, was used.
(Test method)
The test animals used around 330 g of Hartley female guinea pigs in each group. In the guinea pig breeding room adjusted to a temperature of 22 ± 1 ° C and humidity of 50 ± 10% by the all-fresh method, water is freely ingested with tap water by automatic water supply, and the feed is a solid feed made of oriental yeast ( RC-4). Skin sensitization test was performed by the Maximization Test method (Magnusson, B., and Kligman, AM: Allergic Contact Dermatitis in the Guinea Pig. Identifications of Contact Allergens, Charles C Thomas, Publisher Springfield, Illinois, USA (1970)), Date of September 11, 1997: Drug Notice No. 24, Ministry of Health and Welfare Pharmacy Bureau Examination 1st Division, Examination 2nd Division / Biologics Division Manager's Notice on “Guidelines for Toxicology Tests Required for Pharmaceutical Manufacturing (Import) Approval Application”) I went with reference. Sensitization was performed by intradermal injection and sticking. First, 0.05 parts each of 3 kinds of emulsions, mixed with equal amounts of distilled water and Freund's Complete Adjuvant, equilibrated with distilled water and Freund's Complete Adjuvant on the dorsal skin of the animal's neck shaved in advance. Intradermal injection was performed symmetrically in mL. One week later, sodium lauryl sulfate (10% in petrolatum) was applied to the intradermal injection site, and the sample was occluded for 48 hours on the same site the next day. Two more weeks after this, induction was performed by sticking. The determination was based on the skin reaction at 24 and 48 hours after removal of the paste, and the skin sensitization of the sample was evaluated according to the following criteria. The results are shown in Table 1.

(Criteria)
No response ... 0
Scattered mild erythema 1
Moderately diffuse erythema ... 2
Intense erythema and edema ... 3

(Test results)
As shown in the table below, no erythema or edema was observed in the results of the determination over 24 and 48 hours after the induction of the sensitized product with the neem leaf extract of this patent. On the other hand, in the conventional product (comparative example), diffuse mild erythema was observed in 2 animals at 24 hours, and diffuse mild erythema was observed in 3 animals at 48 hours. Therefore, it was found that the conventional product has skin sensitization, and the neem leaf extract according to the present invention has lost skin sensitization.

[Test 2] Photosensitization test (sample)
The neem leaf extract of Example 1 was used for the test. As a comparative control, a neem leaf extract (comparative example) obtained by extraction with a 50% 1,3-butylene glycol solution from neem leaves that had not been subjected to steam distillation in advance, which was a conventional extraction method, was used.
(Test method)
The test animals were 10 Hartley female guinea pigs each weighing about 370 g. In the guinea pig breeding room adjusted to a temperature of 22 ± 1 ° C and humidity of 50 ± 10% by the all-fresh method, water is freely ingested with tap water by automatic water supply, and the feed is a solid feed made of oriental yeast ( RC-4). The photosensitization test is the Adjuvant-Strip method (Akihisa Sato et al .: Photocontact sensitization test method with guinea pig (Adjuvant-Strip method), Nishi-Nichi skin, 42 (5), 831-837 (1980)), (Heisei According to “Notification Guidelines for Toxicology Necessary for Drug Manufacturing (Import) Approval Application”, dated September 11, 1997 went.
First, 0.1 mL of each emulsion mixed with equal amounts of distilled water and Freund's Complete Adjuvant was injected intradermally into the skin of the back of the neck of the animal shaved in advance. Then, the stratum corneum at the site of intradermal injection is peeled off with cellophane tape, and 0.1 mL of the test drug is applied to the site openly, and then about 10 J / cm ² of long wavelength ultraviolet rays (Toshiba FL-40S / BLB lamp) is applied. Irradiated. In order to eliminate the influence of ultraviolet rays of 320 nm or less, irradiation was performed through a glass filter having a thickness of 3 mm. This operation was performed once a day for a total of 5 days. Photo-induction was performed 3 weeks after the start of photosensitization. In other words, both sides of the midline of the back skin of the shaved animal are taken as test sections, 0.02 mL of the test drug is applied to each section open, and one side is shielded with aluminum foil, and then the length is about 10 J / cm ² Irradiated with ultraviolet light of wavelength. The determination was made by comparing the reaction between the light irradiation site and the non-light irradiation site at 24 and 48 hours after irradiation, and evaluating the photosensitization property of the test drug according to the following determination criteria. The results are shown in Tables 2 and 3.

(Criteria)
(1) Erythema No erythema ... 0
Very mild erythema (slightly recognized) ... 1
Clear erythema ... 2
Medium to strong erythema ... 3
Strong erythema with light crust formation ... 4
(2) Edema No edema ... 0
Mild edema ... 1
Moderate edema ... 2
Strong edema (bulge of 1mm or more and spread beyond the specimen application site) 3

(Test results)
As shown in the table below, no erythema or edema was observed in the results of the determination over 24 and 48 hours after the induction of the sensitized product with the neem leaf extract of this patent. On the other hand, in the conventional product (Comparative Example 1), extremely mild erythema was observed in 3 animals at the ultraviolet irradiation site at 24 hours, and extremely mild erythema was observed in 2 animals at the non-irradiated site. In addition, an obvious erythema was observed in one animal at an ultraviolet irradiation site at 48 hours, an extremely mild erythema was observed in one animal, and an extremely mild erythema was observed in two animals at an unirradiated site. . Therefore, it was found that the conventional product has photosensitization, and the neem leaf extract according to the present invention has lost photosensitization.

[Test 3] Melanin production inhibition test
B16 melanoma cells are mouse-derived melanin producing cells, and a drug that suppresses the production of melanin in these cells can be expected to lighten the skin color, that is, to whiten.
(sample)
The neem leaf extract of Example 1 was used for the test. As a comparative control, neem leaf extract (comparative example) and arbutin (sigma) obtained by extraction with a 50% 1,3-butylene glycol solution from neem leaves that have not been previously subjected to steam distillation as a conventional control method. A 0.5% solution (50% 1,3-butylene glycol solution) was used as a blank, and a 50% 1,3-butylene glycol solution was used as a blank.
(Test method)
B16 melanoma cells were cultured for 24 hours, and this culture medium was replaced with a culture medium to which a sample was added. At this time, purified water was added to the blank. After culturing for 3 days, the cells were treated with trypsin, heated and dissolved in a 1N-NaOH solution containing 10% DMSO, and the absorbance at 420 nm was measured to obtain the amount of melanin. Simultaneously, the number of cells was measured by the MTT reduction method (Tim Mosmann; Journal of Immunological Methods p55-63 (1983) reference), and it was confirmed that there was no difference in the number of viable cells between the blank group and the sample addition group. The results are shown in FIG.

(Test results)
As shown in FIG. 1, the neem leaf extract of the present invention shows a decrease in the amount of melanin that is comparable to that of the conventional product, and further has a melanin production-suppressing effect that exceeds that of arbutin, and is confirmed to be useful as a whitening agent. It was.

[Test 4] Histamine release inhibition test
In type I allergic reactions, chemical mediators such as histamine are released from mast cells or basophils sensitized in the second stage. Therefore, a substance that suppresses histamine release can be expected to have an antiallergic action. In this study, a test method (J. Soc. Cosmet. Japan, Vol. 25, No. 4, P. 246 (1992)) was used to release histamine from rat mast cells using compound 48/80, a histamine-releasing reagent. investigated.
(Sample solution)
The neem leaf extract of Example 1 was used for the test. As a comparison, neem leaf extract (comparative example) and dipotassium glycyrrhizinate obtained by extraction with a 50% 1,3-butylene glycol solution from neem leaves that have not been steam-distilled in advance, which is a conventional extraction method. A 0.5% solution (manufactured by Kishida Chemical) (50% 1,3-butylene glycol solution) was used as a blank and a 1,3-butylene glycol solution was used.
(Test method)
To a 1.2 mL mast cell suspension collected from the abdominal cavity of a rat (Slc: Wister male rat, about 4-9 weeks old), add 0.2 mL of the sample and compound 48/80 to a final concentration of 1 μg / mL. Incubated for 15 minutes at ° C. After stopping the reaction by cooling with ice, the reaction solution is centrifuged, and histamine released from the supernatant is extracted and purified, colored with o-phthaldialdehyde, and measured for fluorescence absorbance at an excitation wavelength of 360 nm and a fluorescence wavelength of 450 nm. The inhibition rate of histamine release was obtained from Equation 1. The results are shown in FIG.

<Equation 1>
Histamine release inhibition rate (%) = {1− (A−C / B−C)} × 100
A: Fluorescence intensity of histamine released when a histamine releasing agent is added in the presence of a sample in mast cells B: Fluorescence intensity of histamine released when a histamine releasing agent is added to mast cells C: Naturally from mast cells Fluorescence intensity of released histamine (A, B, and C are the measured values minus the blinded values.)

(Test results)
As shown in FIG. 2, the neem leaf extract of the present invention has a histamine release inhibitory effect comparable to that of the conventional product, and further has an excellent effect compared to cromolyn, which is widely used as an anti-inflammatory agent. And was found to be useful as an antiallergic agent.

(Prescription Example) Production of Various Compositions Various compositions according to the present invention were produced. Although the formulation example is shown below, this invention is not necessarily limited to these. The “residue” in the formulation examples represents a steam distillation residue.

(Formulation Example 1) Milk Mass%
1.Squalane 5.0
2.Olive oil 5.0
3. Jojoba oil 5.0
4.Cetyl alcohol 1.5
5. Glycerin monostearate 2.0
6.Polyoxyethylene (20) cetyl ether 3.0
7. Polyoxyethylene (20) soorbitan monooleate 2.0
8.1,3-Butylene glycol 1.0
9.Glycerin 2.0
10. A: Invention product of Example 1 B: Invention product of Example 2 C: Invention product of Example 3 * A to C extract of any one type 1.0
11. Preservative (paraoxybenzoic acid ester) appropriate amount
12.Perfume appropriate amount
13. Residue with 100 purified water

(Formulation Example 2) Milk Mass%
1. Squalane 8.0
2. Jojoba oil 7.0
3. Neem residue 30% 1,3-butylene glycol solution 3.0
4. Vitamin C phosphate magnesium salt 1.0
5.Cetyl alcohol 1.5
6. Glycerin monostearate 2.0
7.Polyoxyethylene (20) cetyl ether 3.0
8.Polyoxyethylene (20) soorbitan monooleate 2.0
9.1,3-Butylene glycol 1.0
10.Glycerin 2.0
11. Pig placenta water extract 3.0
12. Preservative (paraoxybenzoic acid ester) appropriate amount
13. Residue with 100 purified water

(Formulation Example 3) Cosmetic Oil Mass%
1.liquid paraffin 30.0
2.Squalane 20.0
3.Olive oil 20.0
4.Isopropyl palmitate 10.0
5. Neem leaf residue ethanol extraction powder 0.5
6.Olive oil 1.0
7. Shea fat 1.0
8.Butylhydroxyanisole 0.1
9. Vitamin E derivative 0.1
10. Preservative (benzalkonium chloride) appropriate amount
11. Perfume (today water) appropriate amount
12.Residue with 100 purified water

(Formulation example 4) Flexible lotion mass%
1.Glycerin 5.0
2.1,3-Butylene glycol 5.0
3.Polyoxyethylene sorbitan monolaurate (20E.O) 1.0
4.Ethanol 15.0
5. A: Invention product of Example 1 B: Invention product of Example 2 C: Invention product of Example 3 * A to C one of the extracts 1.0
6.Shimeji hot water extract 1.0
7. Enokitake hot water extract 1.0
8. Antibacterial and antiseptic (Lactoferrin solution)
9. Fragrance (Western light load water) appropriate amount
10. Residue with 100 purified water

(Formulation Example 5) Astringent lotion
1.Sorbit 2.0
2. POE (20) oleyl alcohol 1.0
3.Ethanol 15.0
4. Assembly 50% 1,3-butylene glycol extract 2.0
5. Yeast 50% 1,3-butylene glycol extract 2.0
6. Neem bark residue 50% 1,3-butylene glycol extract 2.0
7. Allantoin 0.2
8. Astringent (Zinc Sulfocolate) 0.2
9. Antibacterial and antiseptic (thiamin lauryl sulfate) appropriate amount
10. Perfume (lavender water) appropriate amount
11. Residue with 100 purified water

(Prescription Example 6) Two-layer lotion (liquid to liquid type)
1. Squalane 8.0
2. POE sorbitan tetraoleate 0.3
3.Sorbit 1.0
4.Ethanol 15.0
5. Neem leaf residue 30% ethanol extract 3.0
6.Ascorbic acid 0.2
7. Astringent (calamine) 0.1
8. Preservative (phenoxyethanol) appropriate amount
9. Fragrance (lemon water) appropriate amount
10. Residue with 100 purified water

(Formulation example 7) Carmine lotion (liquid to solid type)
1.Glycerin 3.0
2.1,3-Butylene glycol 5.0
3.Ethanol 15.0
4. Iron oxide (Bengara) 0.2
5.Zinc oxide 0.5
6.Kaolin 2.0
7. Invention product 1 of Production Example 3.0
8. Chamomile flower 50% propylene glycol extract 2.0
9. Preservative (photosensitive element 201 & 401) appropriate amount
10. Fragrance (Bodhi Tree Water) Appropriate amount
11. Residue with 100 purified water

(Formulation example 8) Pack mass%
1.Polyvinyl alcohol 15.0
2.Carboxymethylcellulose sodium 5.0
3.Propylene glycol 3.0
4.Ethanol 10.0
5. Neem leaf residue 50% glycerin extract 5.0
6. Preservative (paraoxybenzoic acid ester) appropriate amount
7. Fragrance (rose water) appropriate amount
8. Residue with 100 purified water

(Formulation example 9) Peel-off pack mass%
1.Glycerin 5.0
2.Propylene glycol 4.0
3.Polyvinyl alcohol 15.0
4.Ethanol 8.0
5.Polyoxyethylene glycol 1.0
6. Pantothenyl ethyl ether 1.0
7. Neem leaf residue 30% ethanol extract 2.0
8. Preservative (paraoxybenzoic acid ester) appropriate amount
9. Fragrance (Makihasui) appropriate amount
10. Residue with 100 purified water

(Prescription Example 10) Cold cream mass%
1. Sarah Beeswax 11.0
2.liquid paraffin 22.0
3.Lanoline 10.0
4.Olive oil 5.0
5. Chamomile oil 5.0
6. Palm oil 5.0
7.borax 0.5
8. Neem leaf residue extract 2.0
(Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent)
9.Liquid shea fat 1.0
10. Preservative (Acrinol) 0.1
11. Perfume (sage water) appropriate amount
12.Residue with 100 purified water

(Formulation example 11) Emollient cream mass%
1.Stearic acid 2.0
2. Stearyl alcohol 7.0
3.Reduced lanolin 2.0
4.Squalane 5.0
5. Octyldodecanol 6.0
6. Polyoxyethylene cetyl ether (25E.O.) 3.0
7. Lipophilic glyceryl monostearate 2.0
8.Propylene glycol 5.0
9. Neem leaf residue 30% ethanol extract 5.0
10. Preservative (paraben) appropriate amount
11. Perfume (clove water) appropriate amount
12.Residue with 100 purified water

(Formulation example 12) Facial cleansing cream mass%
1.Myristic acid 25.0
2.Stearic acid 5.0
3. Tallow fatty acid 5.0
4.Propylene glycol 10.0
5.Potassium hydroxide 6.0
6. Palm oil fatty acid diethanolamide 6.0
7. Neem leaf residue 45% ethanol extract 2.0
8.Bifidobacterium extract 1.0
9.Dipotassium glycyrrhetinate 1.0
10. Preservative (salicylic acid) 0.1
11. Perfume (sage water) appropriate amount
12.Residue with 100 purified water

(Prescription Example 13) Face-wash cream%
1.Stearic acid 10.0
2.palmitic acid 10.0
3.Myristic acid 12.0
4.Lauric acid 4.0
5.Oleyl alcohol 1.5
6. Lanolin derivative (EO adduct) 1.0
7.Glycerin 18.0
8.Potassium hydroxide 6.0
9. A: Invention product of Example 1 B: Invention product of Example 2 C: Invention product of Example 3 * A to C extract of any one type 1.0
10. Royal Jelly Extract 1.0
(Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent)
11.Glycyrrhizic acid 1.0
12. Antiseptic (salicylic acid) 0.1
13. Fragrance (mugwort water) appropriate amount
14. Residue with 100 purified water

(Prescription Example 14) Body soap mass%
1.Potassium laurate 15.0
2.Potassium myristate 5.0
3.Propylene glycol 5.0
4. Neem leaf residue 30% 1,3-butylene glycol extract 5.0
5.Polyethylene powder 0.5
6.Hydroxypropyl chitosan solution 0.5
7. Amino acids (Glycine, Glutamine, etc.) 0.5
8. Preservative (undecylenic acid, phenol) appropriate amount
9.pH adjuster
10. Perfume (lavender water) appropriate amount
11. Residue with 100 purified water

(Formulation Example 15) Sunscreen cosmetics (O / W type)
1.Oxybenzone 2.0
2.Octyl paramethoxycinnamate 5.0
3.Squalane 10.0
4.Vaseline 5.0
5. Stearyl alcohol 3.0
6.Stearic acid 3.0
7. Glyceryl monostearate 2.0
8.Polyethyl acrylate 1.0
9.1,3-Butylene glycol 6.0
10.Edetate disodium 0.1
11.Triethanolamine 1.0
12.Titanium dioxide 5.0
13. Neem leaf residue 50% dipropylene glycol extract 1.5
14. Preservative (paraben) appropriate amount
15. Perfume (apple water) appropriate amount
16.Residue with 100 purified water

(Prescription Example 16) Sunscreen cosmetics (oil type)
1.liquid paraffin 70.0
2.Ethyl paraaminobenzoate 1.0
3.Tetrahydroxybenzophenone 1.0
4.Cetyl octanoate 25.0
5. Neem bark residue 30% 1,3-butylene glycol extract 1.0
6. Chamomile flower 10% 1,3-butylene glycol extract 1.0
7. Antioxidant (Butylhydroxytoluene)
8. Fragrance (cornflower water) appropriate amount

(Prescription example 17) Cream foundation (O / W type)
1. Stearic acid 4.0
2.Glycerol monostearate3.0
3.Cetanol 1.5
4.Isopropyl myristate 7.0
5. Liquid paraffin 10.0
6. Sarah Beeswax 3.0
7.Triethanolamine 1.5
8.Glycerin 3.0
9. Bentonite 1.0
10.Titanium oxide 8.0
11.2,4-Dihydroxybenzophenone 8.0
12.Kaolin 3.0
13. Talc 3.0
14. Colored pigment (yellow iron oxide) 1.0
15. Neem leaf residue 70% ethylene glycol extracted dry powder 0.5
16. Preservative (phenoxyethanol) appropriate amount
17. Fragrance (rose water) appropriate amount
18.Residual water 100

(Prescription Example 18) Shampoo Mass%
1.Lauryl sulfate triethanolamine 5.0
2. Sodium polyoxyethylene lauryl ether sulfate 12.0
3.1,3-Butylene glycol 4.0
4.Lauric acid diethanolamide 2.0
5. Edetate disodium 0.1
6. Neem leaf residue 50% 1,3-butylene glycol extract 5.0
7. Tamshiba 30% 1,3-butylene glycol extract 6.0
8.Hydroxypropyl chitosan solution 2.0
9. Mucopolysaccharide solution 1.0
10. Antibacterial and antiseptic (photosensitive element 101) appropriate amount
11.pH adjuster
12. Perfume (white sand water) appropriate amount
13. Residue with 100 purified water

(Formulation example 19) Rinse mass%
1. Stearyltrimethylammonium chloride 2.0
2.Cetostearyl alcohol 2.0
3.Polyoxyethylene lanolin ether 3.0
4.Propylene glycol 5.0
5. Honokiol 1.0
6. Neem bark residue 50% ethanol extract 1.0
7.Hydroxyethyl chitosan solution 1.0
8. Trehalose solution 1.0
9. Hydrolyzed silk solution 1.0
10. Antibacterial and antiseptic (benzalkonium chloride) appropriate amount
11. Perfume (lavender water) appropriate amount
12.Residue with 100 purified water

(Formulation example 20) Rinse mass%
1. Stearyltrimethylammonium chloride 2.0
2.Cetostearyl alcohol 2.0
3.Polyoxyethylene lanolin ether 3.0
4.Propylene glycol 5.0
5.Ethylene glycol 3.0
6. Neem leaf residue 30% 1,3-butylene glycol extract 3.0
7. Taisangbok 30% 1,3-butylene glycol extract 3.0
8. Trehalose solution 1.0
9. Hydrolyzed keratin solution 1.0
10. Antibacterial and antiseptic (benzalkonium chloride) appropriate amount
11. Fragrance (camomile water) appropriate amount
12.Residue with 100 purified water

(Formulation Example 21) Hair Liquid Mass%
1.Ethanol 29.0
2.Polyoxypropylene butyl ether phosphate 10.0
3.Polyoxypropylene monobutyl ether 5.0
4.Triethanolamine 1.0
5. Honoki hot water extract 4.0
6. Carpronium chloride 0.3
7. Neem leaf residue 30% 1,3-butylene glycol extract 1.0
8.Keratin degradation solution 1.0
9. Antibacterial and antiseptic (paraben, benzalkonium chloride) appropriate amount
10. Fragrance (Rosehip water)
11. Residue with 100 purified water

(Formulation Example 22) Hair Liquid Mass%
1.Ethanol 29.0
2.Polyoxypropylene butyl ether phosphate 10.0
3.Polyoxypropylene monobutyl ether 5.0
4.Triethanolamine 1.0
5.Trimethylene glycol 5.0
6. Magnolia 50% ethanol extract 3.0
7. Neem bark residue 50% ethanol extract 3.0
8.Azulene 1.0
9. Antibacterial and antiseptic (paraben, benzalkonium chloride) appropriate amount
10. Fragrance (jasmine water)
11. Residue with 100 purified water

(Prescription example 23) Hair artnic mass%
1.Ethanol 40.0
2.Ethyl oleate 1.0
3.Polyoxyethylene (40) hydrogenated castor oil 2.0
4. A: Invention product of Example 1 B: Invention product of Example 2 C: Invention product of Example 3 * A to C extract of any one type 1.0
5. Comfrey leaf or stem 50% ethanol extract 3.0
6. Lettuce leaf 50% ethanol extract 3.0
7. Preservative (phenoxyethanol) 0.1
8. Residue with 100 purified water

(Prescription example 24) Hair artnic mass%
1. l-menthol 0.2
2.Ethanol 32.5
3.Polyoxyethylene hydrogenated castor oil 0.5
4.Propylene glycol 5.0
5.Diphenhydramine hydrochloride 0.3
6. Neem leaf residue ethanol extract 1.0
7.Carboxymethylchitin solution 1.0
8. Vitamin E derivative 0.5
9. Antibacterial and antiseptic (paraben) 0.1
10. Perfume (sage water) appropriate amount
11. Residue with 100 purified water

(Prescription Example 25) Hair growth / hair growth agent
1.Ethanol 60.0
2. Neem bark residue ethanol extract 5.0
3. Vitamin E derivative 0.5
4.Pepper tincture 0.5
5.Resorcin 0.5
6.Dipotassium glycyrrhizinate 0.5
7.Carboxymethylchitin solution 0.5
8. Porcine hematin solution 0.5
9. Porcine mucin solution 0.5
10. Amino acids (Glycine, Glutamine, etc.) 0.5
11. Antibacterial and antiseptic (paraben) 0.1
12. Fragrance (rosemary water)
13. Residue with 100 purified water

(Formulation Example 26) Hair growth / hair growth agent
1.Ethanol 60.0
2. Neem leaf residue 30% 1,3-butylene glycol extract 2.0
3. Udo 50% 1,3-butylene glycol extract 2.0
4. Cantalis tincture 0.5
5. Pantothenic acid derivative 0.5
6.Glycyrrhizic acid 0.5
7.Resorcin 0.5
8.salicylic acid 0.5
9.Hydroxyethyl chitosan solution 0.5
10.Elastin hydrolysis solution 0.5
11. Antibacterial and antiseptic (paraben) 0.1
12. Fragrance (lavender water) appropriate amount
13. Residue with 100 purified water

(Prescription Example 27) Granule bath agent
1.Sodium bicarbonate 58.0
2.Anhydrous sodium sulfate 30.0
3. Borax 2.0
4. Neem bark residue hot water extract dry powder 1.0
5. Paracoumaric acid 2.0
6. Pigment (Gunjo green) appropriate amount

(Prescription Example 28) Granule bath agent
1.Sodium bicarbonate 58.0
2.Anhydrous sodium sulfate 30.0
3. Borax 4.0
4. A: The dry powder of the product of the present invention of Example 1 B: The dry powder of the product of the present invention of Example 2 C: The dry powder of the product of the present invention of Example 3
5. Apple fruit juice powder 1.0
6. Dye (Gunjou, chromium hydroxide) appropriate amount
7. Fragrance (Roman chamomile water)

(Prescription example 29) Coating protective agent A gauze or liniment cloth is impregnated with a prescription solution prepared by mixing an appropriate amount of the product of the present invention of Example 1, antibiotics, anti-inflammatory agents, etc., and attached to the wound. These may be directly sprayed locally and covered with gauze or the like.

It is a figure which shows the melanin production inhibitory effect of this invention goods. It is a figure which shows the histamine release inhibitory effect of this invention goods.

Claims (2)

A method for producing a neem extract, which is obtained by solvent extraction from a steam distillation residue of Melia azadirachta L .. A hypoallergenic cosmetic composition comprising a neem extract obtained by the production method according to claim 1.

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