JP4814509B2 - Melanin production inhibitor containing diarylheptanoid derivative as an active ingredient, skin external preparation, and application to food and drink - Google Patents

Description

The present invention relates to a melanin production inhibitor comprising at least one selected from diarylheptanoid derivatives. More specifically, the present invention relates to a novel melanin production inhibitor having an excellent whitening effect, high skin safety, and excellent quality stability .

  Skin pigmentation is simply caused by the high accumulation of melanin pigments globally or locally in the skin as a result of the production of melanin pigments in the skin by various external factors. That is, it has been considered that skin pigmentation can be controlled by inhibiting or controlling this in vivo reaction in some form, and conventionally, for example, inhibition of melanin producing enzyme activity, Lightening due to degradation, etc., and more recently, regulation and suppression of gene expression of melanogenesis-related enzymes, suppression of intracellular or intercellular signaling that controls melanogenesis, suppression of activation of melanocytes themselves, which are melanocytes Molecular biological studies have also been studied.

And in the field of skin external preparations such as cosmetics, based on the above-mentioned knowledge, for example, ascorbic acid or its derivative, kojic acid or its derivative, cinnamic acid derivative or chromone derivative, resorcin glycoside, amine derivative, chlorogenic acid or Derivatives, unsaturated fatty acids, flavanone, catechin derivatives, arbutin, etc., legumes such as licorice, kudzu, lilyaceae plants such as Enraiso, janohige, asteraceae plants such as leopard ears, inchinko, etc. Gramineae plants, Myrtaceae plants such as clove, cucurbitaceae plants such as vines, hangeres and aloe, camellia plants such as tea, various plant extracts such as algae, and animals and microorganisms such as lactoferrin and lactoferrin degradation products Various whitening agents such as related components have been developed so far (see, for example, Non-Patent Document 1).
Noriyuki Omori, FRAGRANCE JOURNAL Special Issue, No. 14, 1995, 118-126

  However, the above-mentioned whitening agents have poor stability and solubility in the prescription system, have a bad smell due to starch, decomposition, coloration, are not sufficiently effective at the living body level, and cause skin irritation. There was a problem with the characteristics, and it was not satisfactory for consumers' demands in actual use.

  Therefore, the present inventors have sought a new melanin production inhibitor that has a strong effect on the living body level and has no problems in both stability and safety, and has developed a skin blackness caused by exposure to spots, freckles, dullness, or ultraviolet rays. It is an object of the present invention to provide a component having a whitening effect such as effective suppression and improvement of skin pigmentation such as chemical conversion and its application.

  As a result of intensive studies by the present inventors to solve the above-mentioned problems, it has been found that a specific extract fraction of a maple family of the maple family has an excellent melanin production inhibitory effect. As a result of further investigation of the active ingredient, it was found that the strong active main ingredient is a diarylheptanoid derivative, and that they are components that satisfy both the stability over time in the prescription system and the safety to the human body. As a result, the present invention was completed.

The present invention provides a melanin production inhibitor comprising at least one selected from compounds 1 to 6 represented by general formula 1 and diarylheptanoid derivatives of compound 7 represented by general formula 2. Is .

  The diarylheptanoid derivative, which is an active ingredient of the present invention, has an excellent melanin production inhibitory effect, and by applying this to a topical skin preparation, food and drink, skin caused by exposure to spots, freckles, dullness or ultraviolet rays It has become possible to provide a whitening effect such as effective suppression and improvement of skin pigmentation such as blackening. In addition, since the melanin production inhibitor, the external preparation for skin of the present invention, and foods and drinks have good stability over time and are very safe for the human body, pharmaceuticals, quasi drugs, functional foods It can be used in a wide range in such fields.

The diarylheptanoid derivative of the present invention can be extracted from a plant or the like belonging to the genus Maple. Although it does not specifically limit as a plant which belongs to the maple family, Acer palmatum Thunberg, Acer buergerianum, Acer palmatum var.matsumurae, Acer negundo, Acer mono Acer japonicum, Acer rubrum, Acer nikoense Maxim., Acer rufinerve, Acer oblongum subsp. Itoanum, Cerde und Linn.), Mined maple (Acer tschonoskii), etc., and the use site is preferably leaves or bark.

The extraction method is not particularly limited as long as it does not contradict the object of the present invention.For example, after extracting the leaf or bark of the plant as described above with hexane, the residue is extracted again with a hydrophilic extraction solvent, and further By purifying the extract by column chromatography or the like, the following compounds can be obtained.
In addition to compounds 1-7 used in the present invention,
Compound 8: In general formula 3, R1: OH, R2: H, R3: OH, R4: OH
Compound 9: In general formula 1, R1: H, R2: O-Glu-Api, R3: OH

  Examples of the hydrophilic extraction solvent include alcohols such as methanol, ethanol, 2-propanol, 1,3-butylene glycol, and glycerin, water, mixed solvents thereof, and the like, preferably methanol, ethanol, 2- Propanol, 1,3-butylene glycol. The diarylheptanoid derivative used in the present invention can be used as an extract with a hydrophilic extraction solvent or as a concentrate thereof. Moreover, as long as the effect of this invention is not impaired, what dried hexane extraction residue as it is may be used. The diarylheptanoid derivatives of the present invention are not limited to those derived from plant extracts, but also include synthetic products obtained by chemical synthesis methods and the like.

The melanin production inhibitor according to the present invention, the external preparation for skin produced using the same, and the dosage form of food and drink are arbitrary, ampoules, capsules, powders, granules, pills, tablets, solids, Liquid, gel, foam, emulsion, cream, ointment, sheet, mousse, powder dispersion, multilayer, aerosol, and the like can be used.

  Specific examples of external preparations for skin (including preparations used for animals) include ampoules, capsules, pills, tablets, powders, granules, solids, liquids, gels, bubbles, emulsions, sheets, mists, sprays, etc. Appropriate forms of 1) pharmaceuticals, 2) quasi drugs, 3) topical or systemic skin cosmetics (for example, lotions, emulsions, creams, ointments, lotions, oils, packs, etc. Cosmetics, facial cleansers and skin cleansers, massage agents, cleansing agents, depilators, depilators, shaving treatments, after shave lotion, pre-show lotion, shaving cream, foundation, lipstick, blusher, eye shadow, eye Makeup cosmetics such as liners and mascaras, perfumes, beauty nails, beauty nail enamel, beauty nail enamel remover, poultices, plasters, tapes, seals Preparations, patches, aerosols, etc.), 4) medicinal and / or cosmetic preparations applied to the scalp and hair (eg shampoos, rinses, hair treatments, pre-hair treatments, permanent solutions, hair dyes) Hair conditioner, hair styling agent, hair growth / hair nourishing agent, poultice agent, plaster agent, tape agent, sheet agent, aerosol agent, etc.), 5) bathing agent used in bath water, 6) other anti-odor agents Examples include deodorants, antiperspirants, sanitary products, sanitary cotton, and wet tissue.

  Food and beverage products include oral compositions (gum, candy, etc.), processed fish paste products such as kamaboko and chikuwa, livestock products such as sausages and ham, Western confectionery, Japanese confectionery, raw noodles, Chinese noodles, boiled noodles, buckwheat, etc. Seasonings such as noodles, sauce, soy sauce, sauce, sugar, honey, powdered candy, syrup, etc., spices such as curry powder, mustard powder, pepper powder, jam, marmalade, chocolate spread, pickles, red vegetables, sprinkles, or Processed vegetables and fruits such as canned and bottled vegetables, dairy products such as cheese, butter, yogurt, miso soup, soup, fruit juice, vegetable juice, whey drink, soft drink, alcoholic beverages, etc. It can be used as health food, functional food, etc. and general food and drink.

  When the diarylheptanoid derivative of the present invention is applied to an external preparation for skin and foods and drinks, it is usually used as a solid component in an amount of about 0.00001 to 10% by weight, preferably about 0.0001 to 5% by weight. Good melanin production inhibitory effect is obtained. In the case of a bath preparation, the prescription may be taken into consideration so that it is poured into 200 to 300 L of hot water and has a concentration equivalent to the content defined in other skin external preparations.

In addition, the melanin production inhibitor of the present invention, an external preparation for skin produced using the same , and food and drink, in addition to the essential components described above, other pigmentation inhibitors exemplified below, tyrosinase activity inhibitors, Melanocyte melanin production inhibitor, moisturizer, cell activator / metabolic activator, antioxidant, active oxygen scavenger / radical production inhibitor, fat metabolism promoter, UV protection / UV absorption promoter, astringent, anti Inflammatory agent / interleukin production inhibitor / anti-inflammatory agent, antiseborrheic agent, antibacterial agent / antiviral agent, blood flow promoter / vascular stimulant, antiandrogen agent, structural proteolytic enzyme (elastase, collagenase, keratin protease, serine Protease, integrin degrading enzyme, involucrin degrading enzyme, filaggrin degrading enzyme, laminin degrading enzyme, fibronectin degrading enzyme, proteogli Activity inhibitors / structural proteinase inhibitors, structural protein synthesis promoters, mucopolysaccharide (hyaluronic acid, chondroitin sulfate, etc.) degrading enzyme inhibitors, mucopolysaccharide synthesis promoters, intercellular lipid production Active ingredients such as promoters / intercellular lipid condition improvers, keratolytic agents / stratum exfoliation promoters, plasminogen activator antagonist inhibitors, Maillard reaction inhibitors, testosterone 5α reductase activity inhibitors, odorant elimination agents, etc. In addition, components such as extracts and metabolites derived from plant raw materials, animal raw materials, microbial raw materials, other natural product raw materials, etc. that are preferably used for forming a form of whitening agent or whitening cosmetic, or By selecting and using various compounds as additives, in addition to the above-mentioned various whitening effects, excellent skin external preparations having various functions, drinking Can provide food. The content in these preparations is not particularly specified, but it is generally used in a concentration range of 0.0001 to 50% by weight.

(1) Pigmentation inhibitor
p-aminobenzoic acid derivatives, salicylic acid derivatives, benzenesulfonamide derivatives, imidazole derivatives, naphthalene derivatives, hydroxyanthranilic acid or its salts and derivatives thereof, anthranilic acid derivatives, coumarin derivatives, amino acid derivatives (2-amino-3- [ 1-carboxyl-2- (1H-imidazol-4-yl) ethyl] aminobutanoic acid, 2-amino-3- [1-carboxyl-2- (1H-imidazol-4-yl) ethyl] aminobutanoic acid Hydrochloride, 2-amino-3- [1-carboxyl-2- (1H-imidazol-4-yl) ethyl] aminobutanoic acid sodium salt, 2-amino-3- [1-carboxyl-2- (1H- Imidazol-4-yl) ethyl] aminobutanoic acid potassium salt, etc.), benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives , Furan derivatives, pyrone derivatives, nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives, ascorbic acid or salts thereof and derivatives thereof (phosphoric acid-magnesium ascorbate, ascorbyl palmitate, ascorbyl dipalmitate, hydroxyproline phosphorus ascorbate) Acid ester, 5-o-α-D-glucopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate sodium salt, L-ascorbic acid phosphate potassium salt, L-ascorbic acid phosphate magnesium salt, L- Ascorbic acid phosphate calcium salt, L-ascorbic acid phosphate aluminum salt, L-ascorbic acid sulfate sodium salt, L-ascorbic acid sulfate potassium salt, L-ascorbic acid sulfate magnesium salt, L-ascorbic acid sulfate Ester calcium salt, L-ascorbic acid sulfate aluminum salt, L-ascorbic acid sodium salt, L-ascorbic acid potassium salt, L-ascorbic acid magnesium salt, L-ascorbic acid calcium salt, L-ascorbic acid aluminum salt, 6- o-α-D-galactopyranosyl-L-ascorbic acid, 2-o-β-D-galactopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate Ester sodium salt, L-ascorbic acid sulfate sodium salt, 6-o-acyl ascorbic acid phosphate sodium salt, 6-o-acyl ascorbic acid phosphate ammonium salt, 6-o-acyl ascorbic acid phosphate isopropanol Amine salt, 3-o-isopropyl-L-ascorbic acid, 6-o-alkylascorbic acid phosphate Potassium salt, 6-o-alkylascorbic acid phosphate calcium salt, 6-o-alkylascorbic acid phosphate barium salt, 6-o-alkylascorbic acid phosphate ammonium salt, 6-o-alkylascorbic acid phosphate Acid ester monoethanolamine salt, 6-o-alkylascorbic acid phosphate diethanolamine salt, 6-o-alkylascorbic acid phosphate triethanolamine salt, 6-o-alkylascorbic acid phosphate monoisopropanolamine salt, 6-o-alkylascorbic acid phosphate diisopropanolamine salt, 6-o-alkylascorbic acid phosphate triisopropanolamine salt, 3-o-glycosyl-L-ascorbic acid, 6-o-β-D-galacto Pyranosyl-L-ascorbic acid, cholesterol ascorbyl phosphate Esters, palmitic acid-L-ascorbyl, isopalmitic acid-L-ascorbyl, dipalmitic acid-L-ascorbyl, diisopalmitic acid-L-ascorbyl, stearic acid-L-ascorbyl, isostearic acid-L-ascorbyl, distearic acid -L-ascorbyl, diisostearic acid-L-ascorbyl, myristic acid-L-ascorbyl, isomyristic acid-L-ascorbyl, dimyristic acid-L-ascorbyl, diisomyristic acid-L-ascorbyl, 2-ethylhexanoic acid- L-ascorbyl, di-2-ethylhexanoic acid-L-ascorbyl, oleic acid-L-ascorbic acid, 2-o-α-D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L -Ascorbic acid, 2-o-α-D-maltotriosyl-L-ascorbic acid, 3-o-α-D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid , 2-o-α-D-maru Triosyl-L-ascorbic acid, L-ascorbic acid tetraisopalmitic acid ester, L-ascorbic acid tetralauric acid ester, L-ascorbic acid tetra-2-ethylhexanoic acid ester, L-ascorbic acid tetraoleic acid ester, 5, 6-isopropylidene-L-ascorbic acid, L-ascorbic acid retinol ester, L-ascorbic acid-DL-tocopherol phosphate ester, L-3-o-ethylascorbic acid, L-ascorbic acid tristearate, L-ascorbine Acid tripalmitate, L-ascorbic acid trioleate, L-ascorbic acid triphosphate, 2-o-ascorbyl cinnamate, 2-o-ascorbyl ferrate, 2-o-ascorbyl caffeate, 2-o-ascorbyl cinna Pate, 2-o- [6-palmitoyl ascorbyl] -4'-acetoxyferrate, DL-α-toco Errol-2-L-ascorbic acid phosphoric diester, ascorbic acid inositol binding derivative, ascorbic acid phosphoramide derivative, ascorbyl arbutin conjugate, ascorbyl phosphoryl cholesterol, chromanyl ascorbic acid derivative, ascorbic acid sialic acid derivative, etc.), tocopherol or its Salts and derivatives thereof (α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, ε-tocopherol, α-tocopheryl retinoate, aminomethylated tocopherol, hydroxymethylated tocopherol, tocopheryl phosphate, tocopherol acetate , Tocopherol nicotinate, tocopherol succinate, tocopherol linoleate, tocopherol orotate, DL-α-tocopheryl glucoside, D L-α-tocopheryl maltoside, DL-β-tocopheryl glucoside, DL-β-tocopheryl maltoside, DL-γ-tocopheryl glucoside, DL-γ-tocopheryl maltoside, DL-δ-tocopheryl glucoside DL-δ-tocopheryl maltoside, D-α-tocopheryl glucoside, D-α-tocopheryl maltoside, D-β-tocopheryl glucoside, D-β-tocopheryl maltoside, D-γ-tocopheryl Glucoside, D-γ-tocopheryl maltoside, D-δ-tocopheryl glucoside, D-δ-tocopheryl maltoside, L-α-tocopheryl glucoside, L-α-tocopheryl maltoside, L-β-toco Ferryl glucoside, L-β-tocopheryl maltoside, L-γ-tocopheryl glucoside, L-γ-tocopheryl maltoside, L-δ-tocopheryl glucoside, L-δ-tocopheryl maltoside, 1- (sulfo Ethylamino) -3- (α-toco Eleyl-6-iroxy) propan-2-ol, 1- (carboxypropylamino) -3- (α-tocopheryl-6-iroxy) propan-2-ol hydrochloride, S- [3- (α-toco Ferroyl-6-iroxy) -2-hydroxypropyl] cysteine, S- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] -γ-glutamylcystenylglycine, N- [3- (Α-tocopheryl-6-iroxy) -2-hydroxypropyl] aspartic acid, N- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] glutamic acid, etc.), tocotrienol or a salt thereof And derivatives thereof (α-tocotrienol, β-tocotrienol, γ-tocotrienol, δ-tocotrienol, tocotrienol acetate, tocotrienol nicotinate, tocotrienol succinate, tocotrieno Lurinolate, tocotrienol orotate, etc.), kojic acid or derivatives thereof (2-methoxymethyl-hydroxy-4H-pyran-4-one, 2-ethoxymethyl-5-hydroxy-4H-pyran-4-one, 2-benzoluyl Oxymethyl-5-hydroxy-4H-pyran-4-one, 2-cinnamoyloxymethyl-5-hydroxy-4H-pyran-4-one, 2-phenoxymethyl-5-hydroxy-4H-pyran-4-one Kojic acid glycoside, geranylgeranylacetone, kojic acid monobutyrate, kojic acid monocaprate, kojic acid monopalmitate, kojic acid monostearate, kojic acid monocinnamate, kojic acid monobenzoate, kojic acid dibutyrate, kojic acid dipalmitate , Kojic acid distearate, kojic acid dioleate, etc.), oxybenzone, benzophenone, guaiazulene, shikonin, baika Or salts thereof and derivatives thereof, baicalein or salts thereof and derivatives thereof, berberine or salts thereof and derivatives thereof, chrysin or salts thereof and derivatives thereof, apigenin or salts thereof and derivatives thereof, luteolin or salts thereof and Derivatives thereof, acacetin or a salt thereof and derivatives thereof, diosmethine or a salt thereof and derivatives thereof, kaempferol or a salt thereof and derivatives thereof, triphorin or a salt thereof and derivatives thereof, astragalin or a salt thereof and derivatives thereof Quercetin or a salt thereof and derivatives thereof, quercitrin or a salt thereof and derivatives thereof, isoquercitrin or a salt thereof and derivatives thereof, rutin or a salt thereof and derivatives thereof, morin or a salt thereof and These derivatives, myricetin or a salt thereof and derivatives thereof, myricitrine or a salt thereof and derivatives thereof, datiscetin or a salt thereof and derivatives thereof, quercetagetin or a salt thereof and derivatives thereof, isorhamnetin or a salt thereof and derivatives thereof , Pinocembrin or a salt thereof and derivatives thereof, naringenin or a salt thereof and derivatives thereof, hesperetin or a salt thereof and derivatives thereof, eriodictyol or a salt thereof and derivatives thereof, pinobankin or a salt thereof and derivatives thereof, aromaden Dorin or a salt thereof and derivatives thereof, engelitin or a salt thereof and derivatives thereof, taxofolin or a salt thereof and derivatives thereof, astilbine or a salt thereof and derivatives thereof, amperopsin or Salts thereof and derivatives thereof, glutathione or salts thereof and derivatives thereof, isoflavone glycosides (6-o-apiosyl puerarin-4′-o-glucoside, 6-o-glucosyl puerarin, 3′-hydroxy puerarin-4 '-o-glucoside, 6-o-apiosyl-3'-hydroxypuerarin, etc.), γ-pyrone glycoside (maltol-3-o- (6'-o-apiosyl) -glucoside, maltol-3-o- (6'-o-apiosyl) -glucoside, etc.), isononyl ferrate, ellagic acid or its salts and derivatives thereof (5,4-dimethylellagic acid, 3,3'-dimethylellagic acid, 3,3 ', 4-trimethylellagic acid, 3,3 ', 4,4'-tetramethyl-5-methoxyellagic acid, 3-ethyl-4-methyl-5-hydroxyellagic acid, amritoside, etc.), lucinol, ondisaponin, bacmond Usaponin, Ruscogenin, Celicoside, Asian Chicoside, F Deline, Senegin, Benzoic acid anilides (4-hydroxy-N- (2-hydroxyphenyl) benzoic acid amide, 4-hydroxy-N- (3-hydroxyphenyl) benzamide, 4-hydroxy-N- (4-hydroxyphenyl) ) Benzamide, 3,5-di-t-butyl-4-hydroxy-N- (4-hydroxyphenyl) benzamide, 3,5-di-t-butyl-4-hydroxy-N- (3-hydroxyphenyl) benzamide , 3,5-di-t-butyl-4-hydroxy-N- (2-hydroxyphenyl) benzamide, etc.), diphenylpyraline, cyproheptadine, triprolysine, dimethindene, ozagrel, istipendyl, iproheptin, homochlorcyclidine, alimemazine, Bucillamine, oxytosamide, vidarabine, xanthotoxol, phenylmercury hexachlorophene, mercuric oxide, mercuric chloride, hydrogen peroxide Zinc peroxide, placenta (bovine origin, pig origin, horse origin, sheep origin, etc.) extract, almond extract, amaranth extract, octopus extract, lobster extract, querca extract, kofuyou extract, uncaria extract , Geijicha extract, citrus extract, licorice extract, gardenia extract, cranigean extract, clara extract, scallop (wagon) extract, wheat (wheat) extract, rice (rice) extract, Koreaia extract, Sidwaya extract, sunflower Cucumber extract, Sanvitro extract, Sunpens extract, Silane (river cucumber) extract, Senkyu (river cucumber) extract, Senna extract, Senpukuka extract, Sentsutsusai extract, Surigatin extract, Nodake (maehu) extract, pearl barley (yokuinin) Extract, Hamagoueki , Honey beetle extract, hamamelis extract, palm extract, parietaria extract, safflower (safflower) extract, mugwa (mulberry bark) extract, malvanojadin (bitter ginseng) extract, purple squirrel extract, white squirrels extract, moko Artemisia extract, yashajitsu extract, hongkong extract, bituminous extract, ground lily extract, citrus extract, millipede extract, etc.

(2) Tyrosinase activity inhibitor Ascorbic acid or its salts and derivatives thereof (phosphate-L-ascorbic acid magnesium, ascorbyl palmitate, ascorbyl dipalmitate, ascorbyl hydroxyprophosphate ester, 5-o-α-D -Glucopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate sodium salt, L-ascorbic acid phosphate potassium salt, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate calcium salt, L- Ascorbic acid phosphate aluminum salt, L-ascorbic acid sulfate sodium salt, L-ascorbic acid sulfate potassium salt, L-ascorbic acid sulfate magnesium salt, L-ascorbic acid sulfate calcium salt, L-ascorbic acid sulfate Aluminum Nium salt, L-ascorbic acid sodium salt, L-ascorbic acid potassium salt, L-ascorbic acid magnesium salt, L-ascorbic acid calcium salt, L-ascorbic acid aluminum salt, 6-o-α-D-galactopyranosyl -L-ascorbic acid, 2-o-β-D-galactopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate sodium salt, L-ascorbic acid sulfate Sodium salt, 6-o-acyl ascorbic acid phosphate sodium salt, 6-o-acyl ascorbic acid phosphate ammonium salt, 6-o-acyl ascorbic acid phosphate isopropanolamine salt, 3-o-isopropyl-L -Ascorbic acid, 6-o-alkylascorbic acid potassium phosphate, 6-o-alkylascorbic acid phosphate calcium Um salt, 6-o-alkyl ascorbic acid phosphate barium salt, 6-o-alkyl ascorbic acid phosphate ammonium salt, 6-o-alkyl ascorbic acid phosphate monoethanolamine salt, 6-o-alkyl ascorbine Acid phosphate ester diethanolamine salt, 6-o-alkylascorbic acid phosphate triethanolamine salt, 6-o-alkylascorbic acid phosphate monoisopropanolamine salt, 6-o-alkylascorbic acid phosphate diisopropanolamine Salt, 6-o-alkylascorbic acid phosphate triisopropanolamine salt, 3-o-glycosyl-L-ascorbic acid, 6-o-β-D-galactopyranosyl-L-ascorbic acid, ascorbic acid phosphate Cholesterol ester, palmitic acid-L-ascorbyl, isopalmitic acid-L- Scorbyl, dipalmitic acid-L-ascorbyl, diisopalmitic acid-L-ascorbyl, stearic acid-L-ascorbyl, isostearic acid-L-ascorbyl, distearic acid-L-ascorbyl, diisostearic acid-L-ascorbyl, myristic acid- L-ascorbyl, isomyristic acid-L-ascorbyl, dimyristic acid-L-ascorbyl, diisomyristic acid-L-ascorbyl, 2-ethylhexanoic acid-L-ascorbyl, di-2-ethylhexanoic acid-L-ascorbyl , Oleic acid-L-ascorbic acid, 2-o-α-D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α-D-maltotriosyl -L-ascorbic acid, 3-o-α-D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α-D-maltotriosyl-L- Ascorbic acid, L-ascorbic acid tetraisopa Mycinate, L-ascorbate tetralaurate, L-ascorbate tetra-2-ethylhexanoate, L-ascorbate tetraoleate, 5,6-isopropylidene-L-ascorbate, L-ascorbine Acid retinol ester, L-ascorbic acid-DL-tocopherol phosphate ester, L-3-o-ethylascorbic acid, L-ascorbic acid tristearate, L-ascorbic acid tripalmitate, L-ascorbic acid trioleate, L -Ascorbyl triphosphate, 2-o-ascorbyl cinnamate, 2-o-ascorbyl ferrate, 2-o-ascorbyl caffeate, 2-o-ascorbyl synapate, 2-o- [6-palmitoyl ascorbyl]- 4'-acetoxyferrate, DL-α-tocopherol-2-L-ascorbic acid phosphate diester, ascorbine Inositol-binding derivatives, ascorbic acid phosphoramide derivatives, ascorbic acid arbutin conjugates, ascorbyl phosphoryl cholesterol, chromanyl ascorbic acid derivatives, ascorbic acid sialic acid derivatives, etc.), hydroquinone or its salts and their derivatives (hydroquinone α-D-glucose, hydroquinone) β-D-glucose, hydroquinone α-L-glucose, hydroquinone β-L-glucose, hydroquinone α-D-galactose, hydroquinone β-D-galactose, hydroquinone α-L-galactose, hydroquinone β-L-galactose, etc. Carbohydrate glycosides, hydroquinone α-D-ribose, hydroquinone β-D-ribose, hydroquinone α-L-ribose, hydroquinone β-L-ribose, hydroquinone α-D-arabinose, hydroquinone β-D-arabinose , 5-quinone sugar glycosides such as hydroquinone α-L-arabinose and hydroquinone β-L-arabinose, hydroquinone α-D-glucosamine, hydroquinone β-D-glucosamine, hydroquinone α-L-glucosamine, hydroquinone β-L-glucosamine , Hydroquinone α-D-galactosamine, hydroquinone β-D-galactosamine, hydroquinone α-L-galactosamine, hydroquinone β-L-galactosamine and other amino sugar glycosides, hydroquinone α-D-glucuronic acid, hydroquinone β-D-glucuron Acids, hydroquinone α-L-glucuronic acid, hydroquinone β-L-glucuronic acid, hydroquinone α-D-galacturonic acid, hydroquinone β-D-galacturonic acid, hydroquinone α-L-galacturonic acid, hydroquinone β-L-galacturonic acid, etc. Hydroquinone glycosides such as uronic acid glycosides, hydro Quinone benzyl ether, 4-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) butane, 5-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) pentane, 6- β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) hexane, 2-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) propane, 2-β-D-glucopyra Hydroquinone hydroxyalkyl ether glycosides such as nosyloxy-1- (4-hydroxyphenoxy) butane and 2-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) propan-3-ol) , Kojic acid or salts thereof and derivatives thereof (2-methoxymethyl-hydroxy-4H-pyran-4-one, 2-ethoxymethyl-5-hydroxy-4H-pyran-4-one, 2-benzoyloxymethyl- 5-Hydroxy-4H-pyran-4-one, 2-cinnamoyloxy Til-5-hydroxy-4H-pyran-4-one, 2-phenoxymethyl-5-hydroxy-4H-pyran-4-one, kojic acid glycoside, geranylgeranylacetone, kojic acid monobutyrate, kojic acid monocaprate, kouji Acid monopalmitate, kojic acid monostearate, kojic acid monocinnamate, kojic acid monobenzoate, kojic acid dibutyrate, kojic acid dipalmitate, kojic acid distearate, kojic acid dioleate, etc.), tocopherol or salts thereof and derivatives thereof (α -Tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, ε-tocopherol, α-tocopheryl retinoate, aminomethylated tocopherol, hydroxymethylated tocopherol, tocopheryl phosphate, tocopherol acetate, tocopherol ni Tinate, tocopherol succinate, tocopherol linoleate, tocopherol orotate, DL-α-tocopheryl glucoside, DL-α-tocopheryl maltoside, DL-β-tocopheryl glucoside, DL-β-tocopheryl maltoside, DL- γ-tocopheryl glucoside, DL-γ-tocopheryl maltoside, DL-δ-tocopheryl glucoside, DL-δ-tocopheryl maltoside, D-α-tocopheryl glucoside, D-α-tocopheryl maltoside, D -β-tocopheryl glucoside, D-β-tocopheryl maltoside, D-γ-tocopheryl glucoside, D-γ-tocopheryl maltoside, D-δ-tocopheryl glucoside, D-δ-tocopheryl maltoside, L-α-tocopheryl glucoside, L-α-tocopheryl maltoside, L-β-tocopheryl glucoside, L-β-tocopheryl maltoside, L-γ-tocopheryl glucoside L-γ-tocopheryl maltoside, L-δ-tocopheryl glucoside, L-δ-tocopheryl maltoside, L- (sulfoethylamino) -3- (α-tocopheryl-6-iroxy) propane -2-ol, 1- (carboxypropylamino) -3- (α-tocopheryl-6-iroxy) propan-2-ol hydrochloride, S- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] cysteine, S- [3- (α-tocopheryl-6-yloxy) -2-hydroxypropyl] -γ-glutamylcystenylglycine, N- [3- (α-tocopheryl- 6-Iroxy) -2-hydroxypropyl] aspartic acid, N- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] glutamic acid, etc.), tocotrienol or its salts and derivatives thereof (α- Tocotrienol, β-tocotrienol, γ-tocotrienol δ-tocotrienol, tocotrienol acetate, tocotrienol nicotinate, tocotrienol succinate, tocotrienol linoleate, tocotrienol orotate, etc.), N-acetyltyrosine or its salts and derivatives thereof, glutathione or its salts and derivatives thereof, ellagic acid or its Salts and derivatives thereof (3,4-dimethylellagic acid, 3,3'-dimethylellagic acid, 3,3 ', 4-trimethylellagic acid, 3,3', 4,4'-tetramethyl-5-methoxy Isonitrile antibiotics such as ellagic acid, 3-ethyl-4-methyl-5-hydroxyellagic acid, amritoside, etc.), isonitrine A, isonitrine B, isonitrine C, isonitrine D, isonitrinic acid E, isonitrinic acid F, dermadein, tricobilidene Substance, orthoric acid derivative (orceric acid, orthophosphoric acid Tylester orcinol, p-geranylorceric acid, p-geranylorceric acid ethyl estergeranylorcinol, p-farnesylorselinic acid, p-farnesylorceric acid ethylester farnesylorcinol, p-dodecanylorceric acid P-dodecanylorceric acid ethyl ester dodecanylorcinol, p-tetradecanylorceric acid, p-tetradecanylorceric acid ethylester tetradecanylorcinol, p-hexadecanylorceric acid, p -Hexadecanylorceric acid ethyl ester hexadecanylorcinol, p-undecanylorceric acid, p-undecanylorceric acid ethylester undecanylorcinol, p-tridecanylorceric acid, p- Tridecanylorceric acid ethyl ester undecanylorcinol , P-pentadecanylorceric acid, p-pentadecanylorceric acid ethyl ester pentadecanylorcinol, ethylhexylorselinic acid, p-ethylhexylorceric acid ethylester ethylhexylorcinol, p-cyclohexylmethylorceric acid P-cyclohexylmethylorceric acid ethyl ester cyclohexylmethylorcinol, p-hydroxyethylhexylorceric acid methyl ester, p-hydroxyethylhexylorceric acid hydroxyethylhexylorcinol, etc.), umbelic acid, brefeldin, oxydesveratrol , Resorcinol derivatives (4-cyclohexylresorcinol), 3-hydroxyketone compounds (1,5-bis (p-hydroxyphenyl) -2-hydroxypentan-4-one, 1,5-bis (o, p-dihydroxyph) Nyl) -2-hydroxypentan-4-one, 1,5-bis (p-hydroxyphenyl-m-methoxyphenyl) -2-hydroxypentan-4-one, etc.), 1,3-diketone compounds (1,5 -Bis (p-hydroxyphenyl) -2,4-pentanedione, 1,5-bis (o, p-dihydroxyphenyl) -2,4-pentanedione, 1,5-bis (p-hydroxyphenyl-m- Methoxyphenyl) -2,4-pentanedione), bishydroxybenzyl amides, γ-aminobutyric acid or its derivatives (N-methyl-γ-aminobutyric acid, N-dimethyl-γ-aminobutyric acid, oleyl γ-aminobutyric acid) Esters, etc.), hydrogen peroxide, zinc peroxide, placenta extract, lucinol, silk extract, acacia extract, acerola extract, ichibi (winter position) extract, weeping birch extract, quercus (gallic) extract, chestnut extract, kamebahikokoshi extract, kurobanahikokoshi Extract, Hikikoshi (life extension grass) extract, Seri extract, Buckwheat extract, Davilia extract, Nazuna extract, Fujibakama (Orchid grass) extract, Chamomile extract, Mulberry extract, Gardenia extract, Japanese cypress extract, Walnut extract, Clara extract, Artemisia extract, Honeysuckle extract, Yellowfin Extract, Bokudami extract, Matsuhodo extract, pearl barley extract, nettle extract, hop extract, hawthorn extract, eucalyptus extract, yarrow extract, altea extract, cinnamon extract, bay extract, hamameris extract, yamagwa extract, bellflower extract, toshishi extract Extract, dry-boiled extract, mahuang extract, senkyu extract, dokkatsu extract, psycho extract, bowfish extract, hamaboufu extract, ougon extract, peony skin extract, peonies Kiss, cranesbill extract, kudzu root extract, licorice extract, gallnut extract, aloe extract, Cimicifuga extract, safflower extract, green tea extract, black tea extract, Ali elixir extract, and the like.

(3) Melanocyte melanin production inhibitor
Lobeline or lobeline derivatives, liquiritin derivatives (such as liquiritin-α-glucoside, liquiritin-α-maltoside), phenylchroman derivatives, chromone derivatives (2-butylchromone, 2-pentylchromone, 2-heptylchromone, 2-nonylchromone, 2- Hexadecylchromone, 2- (1-ethylpentyl) chromone, 2-butyl-7-methoxychromone, 2-pentyl-7-methoxychromone, 2-heptyl-7-methoxychromone, 2-nonyl-7-methoxychromone, 2-pentadecyl-7-methoxychromone, 2- (1-ethylpentyl) -7-methoxychromone, 7-hydroxy-2-methylchromone, 7-hydroxy-2-butylchromone, 7-hydroxy-2-pentylchromone, 7-hydroxy-2-heptylchromone, 7-hydroxy-2-nonylchromone, 7-hydroxy-2-pentadecylchromone, 7-hydroxy-2- (1-ethyl) Rupentyl) chromone), azelaic acid derivatives (azelaic acid monoalkyl ester, azelaic acid dialkyl ester, etc.), phosphatidylglucosamine, lysophosphatidylglucosamine, phenylhydroquinone, 3-β-D-glucopyranosyl manur, 3-β-D -Maltopyranosyl manur, substituted amino acid derivatives (DL-N-formyl-3- (1-naphthyl) alanine, DL-N-acetyl-3- (1-naphthyl) alanine, DL-N-propionyl-3- ( 1-naphthyl) alanine, DL-N-butyryl-3- (1-naphthyl) alanine, DL-N-isobutyryl-3- (1-naphthyl) alanine, DL-N-valeryl-3- (1-naphthyl) alanine DL-N-isovaleryl-3- (1-naphthyl) alanine, DL-N- (2-methylvaleryl) -3- (1-naphthyl) alanine, DL-N- (3-methylvaleryl) -3- (1- Naphthyl) alanine, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine, DL-N-t-butylacetyl-3- (1-naphthyl) alanine, DL-N-pivaloyl-3- (1-naphthyl) alanine, DL-N-caproyl-3 -(1-naphthyl) alanine, DL-N- (2-ethylhexanoyl) -3- (1-naphthyl) alanine, DL-N- (2-methylhexanoyl) -3- (1-naphthyl) alanine, DL-N-Heptanoyl-3- (1-naphthyl) alanine, DL-N-octanoyl-3- (1-naphthyl) alanine, DL-N- (2-propylpentanoyl) -3- (1-naphthyl) alanine DL-N-nonanoyl-3- (1-naphthyl) alanine, DL-N-decanoyl-3- (1-naphthyl) alanine, DL-N-undecanoyl-3- (1-naphthyl) alanine, DL-N- Dodecanoyl-3- (1-naphthyl) alanine, DL-N-tridecanoyl-3- (1-naphthyl) alanine, DL-N-tetradecanoyl-3- (1-naphthyl) alanine, DL-N-pentadecanoyl -3- (1-Naph ) Alanine, DL-N-hexadecanoyl-3- (1-naphthyl) alanine, DL-N-heptadecanoyl-3- (1-naphthyl) alanine, DL-N-octadecanoyl-3- (1-naphthyl) ) Alanine, DL-N-nonadecanoyl-DL-3- (1-naphthyl) alanine, DL-N-icosanoyl-3- (1-naphthyl) alanine, DL-N-acroyl-3- (1-naphthyl) alanine, DL-N-crotoniloyl-3- (1-naphthyl) alanine, DL-N-methacryloyl-3- (1-naphthyl) alanine, DL-N-vinylacetyl-3- (1-naphthyl) alanine, DL-N- Cyclopropanoyl-3- (1-naphthyl) alanine, DL-N- (2-pentenoyl) -3- (1-naphthyl) alanine, DL-N- (4-pentenoyl) -3- (1-naphthyl) alanine DL-N- (2-hexenoyl) -3- (1-naphthyl) alanine, DL-N- (3-hexenoyl) -3- (1-naphthyl) alanine, DL-N- (2-methyl-3- Pentenoyl) -3- (1- Naphthyl) alanine, DL-N-cyclohexenoyl-3- (1-naphthyl) alanine, DL-N- (10-undecenoyl) -3- (1-naphthyl) alanine, DL-N-linoleyl-3- (1-naphthyl) alanine, DL-N-hydroxyacetyl-3- (1-naphthyl) alanine, DL-N- (6-hydroxycaproyl) -3- (1-naphthyl) alanine, DL-N- (8 -Hydroxyoctanoyl) -3- (1-naphthyl) alanine, DL-N- (9-hydroxynonanoyl) -3- (1-naphthyl) alanine, DL-N- (10-hydroxydecanoyl) -3- (1-naphthyl) alanine, DL-N- (11-hydroxyundecanoyl) -3- (1-naphthyl) alanine, DL-N- (12-hydroxydecanoyl) -3- (1-naphthyl) alanine, DL-N-benzoyl-3- (1-naphthyl) alanine, DL-N- (2-hydroxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (3-hydroxybenzoyl) -3- (1 -Naph ) Alanine, DL-N- (4-hydroxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (o-toluyl) -3- (1-naphthyl) alanine, DL-N- (m- Toluyl) -3- (1-naphthyl) alanine, DL-N- (p-toluyl) -3- (1-naphthyl) alanine, DL-N- (1-naphthoyl) -3- (1-naphthyl) alanine, DL-N- (2-naphthoyl) -3- (1-naphthyl) alanine, DL-N- (2-carboxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (3-carboxybenzoyl)- 3- (1-Naphtyl) alanine, DL-N- (4-Carboxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (2-Picolyloyl) -3- (1-naphthyl) alanine, DL- N- (3-picolineoyl) -3- (1-naphthyl) alanine, DL-N- (4-picolineoyl) -3- (1-naphthyl) alanine, DL-N-phenylacetyl-3- (1-naphthyl) Alanine, DL-N- (2-Phenylpropanoyl) -3- (1-naphth ) Alanine, DL-N- (3-phenylbutyryl) -3- (1-naphthyl) alanine, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine, DL-N-valeryl- 3- (1-naphthyl) alanine, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alaninamide, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine methyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine ethyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine propyl ester, DL-N- (4-methylvaleryl) ) -3- (1-naphthyl) alanine-N-butyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine pentyl ester, DL-N- (4-methylvaleryl) -3- ( 1-naphthyl) alanine isopropyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine isobutyl ester, DL-N- (4-methyl) Valeryl) -3- (1-naphthyl) alanine-t-butyl ester), benzolactam derivatives, indolactam derivatives, cedrol, guaioles, 1- (4-hydroxyphenithio) -2-propanol, β-lactoglobulin, 2-methoxy-5-methylphenol, 5-ethyl-2-methoxyphenol, 5-N-propyl-2-methoxyphenol, 5-N-butyl-2-methoxyphenol, 5-N-hexyl-2-methoxyphenol , 5-N-heptyl-2-methoxyphenol, 5-N-decyl-2-methoxyphenol, 5- (1,1-dimethylpropyl) -2-methoxyphenol, 5- (1,1-dimethylbutyl)- 2-methoxyphenol, 5- (1,1-dimethylethyl) -2-methoxyphenol, 2-methoxy-5- (1-methylpentyl) phenol, 2-methoxy-5- (1-methylhexyl) phenol, 2 -Methoxy-5- (3-methylhexyl) pheno , 2-methoxy-5- (6-methylheptyl) phenol, 5- (1,3-dimethylheptyl) -2-methoxyphenol, malvelin, ferguinol, sugiol, cryptojaponol, 1,5-bis [p-hydroxyl Phenyl] -1,4-pentadien-3-one, 1,5-bis [o-hydroxyphenyl] -1,4-pentadien-3-one, 1,5-bis [2,4-dihydroxyphenyl]- 1,4-pentadien-3-one, 1,5-bis [3-methoxy-4-hydroxyphenyl] -1,4-pentadien-3-one, haginin, agrimophor, agrimol, hydrangenol or a derivative thereof, Alkylresorcinol or its derivatives (4-N-butylresorcinol, etc.), Aristolone, Caramenene (Caramenen, 7-hydroxycaramenene, 5-hydroxycaramenene, 7-methoxycaramenen, etc.), trans-umbellic acid, N- α-be Zoyl-L-arginine, N-α-benzoyl-L-arginine ethyl ester or N-α-benzoyl-L-arginine ethyl ester, 5-methyl-2 (3H) -furanone, 2-butene-4-olide, 2 -Hydroxymethylfuran, 2,5-dimethyl-4-hydroxy-3 (2H) -furanone, 2-formylfuran, 3-formylfuran, methyl α-furyl ketone, furfuryl acetate, 2-hydroxy-3-methyl-2 -Cyclopenten-1-one, 2-hydroxy-3,5-dimethyl-2-cyclopenten-1-one, 2,5-dimethyl-4-hydroxy-3 (2H) -thiophenone, 2-hydroxy-3-ethyl- 2-cyclopenten-1-one, tetronic acid, pentanedione, iminodibenzyls (2,2'-iminodibenzyl, imipramine, imipramine hydrochloride, desipramine, desipramine hydrochloride, chlorimipramine, trimipramine, etc.), dibenzocycloheptadiene Kind ( Amitriptyline, amitriptyline hydrochloride, nortriptyline, noxypetitin, etc.), tetrahydrocopalol glycosides (ketotifen fumarate, labda-8 (17), 13-dien-15-ol, tetrahydromanol, tetrahydrocoparol, tetrahydrocoparalol glucoside) , Tetrahydrocoparol galactoside, tetrahydrocoparol maltoside, tetrahydrocoparol cellobioside, tetrahydrocoparol maltotrioside, etc.), spiroether compound, piochelin, phenothiazine compound, promethazine, alimemazine, alimemazine tartrate, triflupromazine, levomepromazine, Chlorpromazine, cyclandelate, 4-carboxymethyloxybenzoic acid, 4-carboxymethyloxy-2-hydroxybenzoic acid, 3- (3-carboxypro Ru-1-oxy) -2-hydroxybenzoic acid, 4- (3-carboxypropyl-1-oxy) benzoic acid, 4- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- ( 3-carboxypropyl-1-oxy) -2-methoxybenzoic acid, 5- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (5-carboxypentyl-1-oxy) -2- Hydroxybenzoic acid, 6- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (10-carboxydecane-1-oxy) -2-hydroxybenzoic acid, 4- (10-carbamoyldecane- 1-oxy) -2-hydroxybenzoic acid, 4- (4-hydroxybutyl-1-oxy) benzoic acid, 4- (4-hydroxybutyl-1-oxy) -2-hydroxybenzoic acid, 4- (4- Acetoxybutyl-1-oxy) benzoic acid, 4- (4-acetoxybutyl-1-oxy) -2-hydroxybenzoic acid, 4- (3-ethoxycarboni) Propyl-1-oxy) -2-hydroxybenzoic acid, 3- (2,3-dihydroxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (4-methoxybutyl-1-oxy) -2-hydroxy Benzoic acid, 4- (2,3-dihydroxypropyl-1-oxy) -2-hydroxybenzoic acid, 4-carboxymethyloxy-2-hydroxybenzoic acid, 3- (3-carboxypropyl-1-oxy) -2 -Hydroxybenzoic acid, 4- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 5- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 6- (3-carboxypropyl) -1-oxy) -2-hydroxybenzoic acid, 4- (5-carboxypentyl-1-oxy) -2-hydroxybenzoic acid, 4- (4-hydroxybutyl-1-oxy) -2-hydroxybenzoic acid, 4- (10-carboxydecane-1-oxy) -2-hydroxybenzoic acid, hydroxytrimethylcyclohexa (2-hydroxy-4- (2,2,6-trimethyl-1-yl-cyclohexane) butane, 4- (2,2,6-trimethyl-1-yl-cyclohexane) -1-butene, 4- ( 2,2,6-trimethyl-1-yl-cyclohexane) -2-butene, 4- (2,2,6-trimethyl-1-yl-cyclohexane) butane, 3-methyl-3-hydroxy-5- (2 , 2,6-Trimethyl-1-yl-cyclohexane) pentane, 3-methyl-1-hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane) pentane, 3-methyl-5- (2 , 2,6-Trimethyl-1-yl-cyclohexane) pentane, 3-methyl-1-hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane) -3-pentene, 3-methyl-3 -Hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane) -1-pentene, 3-methyl-1-hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane) -2-pentene, 2-hydroxy-4- (2,2,6-trimethyl Til-1-yl-cyclohexane) butane and other monosaccharides, disaccharides or trisaccharide glycosides, etc., escinol, parahydroxycinnamic acid-4- (2,2,6-trimethyl-yl-cyclohexane) -2- Butyl ester monosaccharide, disaccharide or trisaccharide glycoside, ondisaponin, bacmond saponin, ruscogenin, sericoside, asiaticoside, hederin, senegin, 4- (2,2,6-trimethyl-1-yl-
Cyclohexane) -2-keto-butane, 4- (2,2,6-trimethyl-1-yl-6-cyclohexene) -2-keto-butane, 4- (2,2,6-trimethyl-1-yl- Cyclohexane) -2-keto-3-butene, 4- (2,2,6-trimethyl-1-yl-6-cyclohexene) -2-keto-3-butene (β-ionone), Lp-hydroxyphenylglycine, Dp-hydroxyphenylglycine, N-benzyloxycarbonyl-Lp-hydroxyphenylglycine, N-benzyloxycarbonyl-Dp-hydroxyphenylglycine, N-benzoyl-Lp-hydroxyphenylglycine, N-benzoyl-Dp-hydroxyphenylglycine, N- (p-methoxybenzoyl) -Lp-hydroxyphenylglycine, N- (p-methoxybenzoyl) -Dp-hydroxyphenylglycine, N- (p-hydroxybenzoyl) -Lp-hydroxyphenylglycine, N- (p- Hydroxybenzoyl) -Dp -Hydroxyphenylglycine, N-acetyl-Lp-hydroxyphenylglycine, N-acetyl-Dp-hydroxyphenylglycine, N-acetyl-Lp-hydroxyphenylglycine ethyl ester, N-acetyl-Dp-hydroxyphenylglycine ethyl ester, N -Acetyl-Lp-hydroxyphenylglycinamide, N-acetyl-Dp-hydroxyphenylglycinamide, Lp-methoxyphenylglycine, Dp-methoxyphenylglycine, Lp-methoxyphenylglycine hydrochloride, Dp-methoxyphenylglycine hydrochloride, 4 -Hydroxy-3-methoxy-L-phenylglycine, 4-hydroxy-3-methoxy-D-phenylglycine, Lp-hydroxyphenylglycine ethylamide, Dp-hydroxyphenylglycine ethylamide, N-tert-butoxycarbonyl-Lp- Hydroxyphenylglycine, N-tert-butoxy Carbonyl-Dp-hydroxyphenylglycine, N-tert-butoxycarbonyl-Lp-methoxyphenylglycine, N-tert-butoxycarbonyl-Dp-methoxyphenylglycine, N-9-fluorenylmethyloxycarbonyl-Lp-methoxyphenylglycine N-9-fluorenylmethyloxycarbonyl-Dp-methoxyphenylglycine, N-9-fluorenylmethyloxycarbonyl-Lp-methoxyphenylglycine benzyl ester hydrochloride, N-9-fluorenylmethyloxycarbonyl- Dp-methoxyphenylglycine benzyl ester hydrochloride, Lp-hydroxyphenylglycinamide, Dp-hydroxyphenylglycinamide, Lp-hydroxyphenylglycine allyl ester p-toluenesulfonate, Dp-hydroxyphenylglycine allyl ester p-toluenesulfonic acid Salt, Lp-hydroxyl Nylglycine benzyl ester p-toluenesulfonate, Dp-hydroxyphenylglycine benzyl ester p-toluenesulfonate, Lp-hydroxyphenylglycine ethyl ester, Dp-hydroxyphenylglycine ethyl ester, Lp-hydroxyphenylglycine ethyl ester hydrochloride , Dp-hydroxyphenylglycine ethyl ester hydrochloride, Lp-hydroxyphenylglycine methyl ester, Dp-hydroxyphenylglycine methyl ester, etc., 1,3-diallylindane-2-carboxylic acids, stachybocins, pheophorbide derivatives, eleucerin, isoeleucerine or 4-β-hydroxyisoeleucerin, eleucerinol, spiroketal derivatives (2- (2,4-hexadinylidene) -1,6-dioxaspiro [4.5] dec-3-ene, 2- (2-hexynylidene)- 1,6-Geo Oxaspiro [4.4] non-3-ene, 2-((4-methylphenyl) methylidene) -6,6-dioxaspiro [4.4] non-3-ene, 2- (2-hexenylidene) -6,6-dioxaspiro [ 4.5] Dec-3-ene, 2- (2-hexenylidene) -1,6-dioxaspiro [4.4] non-3-ene, 2-hexyl-1,6-dioxaspiro [4.4] nonane, 2- (2-hexenyl ) -1,6-dioxaspiro [4.4] nonane, 2- (2-hexynyl) -1,6-dioxaspiro [4.4] nonane, 2-pentyl-1,6-dioxaspiro [4.4] nonane, 1,6-dioxaspiro [ 4.4] nonane, 1,6-dioxaspiro [4.5] decane, 1,7-dioxaspiro [5.5] undecane, 2,3-benzo-4,4-dimethyl-1,6-dioxaspiro [4.4] nonane, 3,4- Benzo-2-pentyl-1,6-dioxaspiro [4.4] nonane, 3,4-benzo-2-hexyl-1,6-dioxaspiro [4.4] nonane, 3,4-benzo-2-octyl-1,6- Dioxas Pyro [4.4] nonane, 2-hexyl-9,9-dimethyl-1,6-dioxaspiro [4.4] nonane, 2- (2,4-hexadinylidene) -1,6-dioxaspiro [4.4] non-3- Ene, etc.), malvalic acid, phosphonic acid derivative or salt thereof, aspergillomalasmin, aminophosphonic acid derivative or salt thereof, diphenhydramine or salt thereof, pregnenolone or derivative thereof, lutein, farnesyl isopropanol derivative, hexahydrofarnesyl acetone, 4- Benzoylamino-2-hydroxybenzoic acid, 5-benzoylamino-2-hydroxybenzoic acid, 4-benzoylaminobenzoic acid, 4- (1-naphthoylamino) -2-hydroxybenzoic acid, 5- (1-naphthoyl) Amino) -2-hydroxybenzoic acid, 4- (2-naphthoylamino) -2-hydroxybenzoic acid, 5- (2-naphthoylamino) -2-hydroxybenzoic acid, 4- (1-na Futoylamino) benzoic acid, 4- (2-naphthoylamino) benzoic acid, 4-phenylaminocarbonylbenzoic acid, 4-phenylaminocarbonyl-2-hydroxybenzoic acid, 5-phenylaminocarbonyl-2-hydroxybenzoic acid, 4 -(1-naphthylaminocarbonyl) benzoic acid, 4- (1-naphthylaminocarbonyl) -2-hydroxybenzoic acid, 5- (1-naphthylaminocarbonyl) -2-hydroxybenzoic acid, 4- (2-naphthylamino) Carbonyl) benzoic acid, 4- (2-naphthylaminocarbonyl) -2-hydroxybenzoic acid, 5- (2-naphthylaminocarbonyl) -2-hydroxybenzoic acid, hexahydrofarnesyl isopropanol derivative, borneol-p-hydroxycinnamic Acid ester glucoside, borneol-p-hydroxycinnamic ester maltoside, borneol-p-hydroxycinnamic acid Stemaltotrioside, cinnamic acid-4- (2,2,6-trimethyl-yl-cyclohexane) -2-butyl ester derivative, 2,4-dihydroxybenzophenone, 1- (2,4-dihydroxyphenyl) -ethanone ( 2 ', 4'-dihydroxyacetophenone), 1- (2,4-dihydroxyphenyl) -1-propanone (2', 4'-dihydroxypropiophenone), 1- (2,4-dihydroxyphenyl) -1- Butanone, 1- (2,4-dihydroxyphenyl) -1-pentanone, 1- (2,4-dihydroxyphenyl) -1-hexanone, 1- (2,4-dihydroxyphenyl) -1-heptanone, 1- ( 2,4-dihydroxyphenyl) -1-octanone, 1- (2,4-dihydroxyphenyl) -1-nonanone, 1- (2,4-dihydroxyphenyl) -1-decanone, 1- (2,4-dihydroxy Phenyl) -1-undecanone, 1- (2,4-dihydroxyphenyl) -1-dodecanone, 1- (2,4-dihydroxy) Phenyl) -1-tetradecanone, 1- (2,4-dihydroxyphenyl) -1-hexadecanone, 1- (2,4-dihydroxyphenyl) -1-octadecanone, 1- (2-hydroxy-4-methoxyphenyl)- Etanone (2'-hydroxy-4'-methoxyacetophenone), 1- (2-hydroxy-4-methoxyphenyl) -1-propanone (2'-hydroxy-4'-methoxypropiophenone), 1- (2- Hydroxy-4-methoxyphenyl) -1-butanone, 1- (2-hydroxy-4-methoxyphenyl) -1-pentanone, 1- (2-hydroxy-4-methoxyphenyl) -1-hexanone, 1- (2 -Hydroxy-4-methoxyphenyl) -1-heptanone, 1- (2-hydroxy-4-methoxyphenyl) -1-octanone, 1- (2-hydroxy-4-methoxyphenyl) -1-nonanone, 1- ( 2-hydroxy-4-methoxyphenyl) -1-decanone, 1- (2-hydroxy-4-methoxyphenyl) -1-undecanone, 1- (2-hydroxy-4-methoxyphenyl) -1-dodecanone, 1- (2-hydroxy-4-methoxyphenyl) -1-tetradecanone, 1- (2-hydroxy-4-methoxyphenyl) ) -1-Hexadecanone, 1- (2-hydroxy-4-methoxyphenyl) -1-octadecanone, 1- (4-hydroxy-2-methoxyphenyl) -ethanone (4′-hydroxy-2′-methoxyacetophenone), 1- (4-hydroxy-2-methoxyphenyl) -1-propanone (4'-hydroxy-2'-methoxypropiophenone), 1- (2,4-dimethoxyphenyl) -ethanone (2 ', 4'- Dimethoxyacetophenone), 1- (2,4-dimethoxyphenyl) -1-propanone (2 ′, 4′-dimethoxypropiophenone), lactone derivatives (1,6-dioxaspiro [4.4] nonane-2,7-dione, 1,6-dioxaspiro [4.5] decane-2,7-dione, 4-tridecanolide, 4-dodecano 4-undecanolide, 4-decanolide, 4-nonanolide, 4-octanolide, 4-heptanolide, 5-dodecanolide, 5-undecanolide, 5-decanolide, 5-nonanolide, 5-octanolide, 2-undecen-4-olide, 2-decene-4-olide, 2-nonene-4-olide, 2-heptene-4-olide, 2-undecen-5-olide, 2-decene-5-olide, 2-nonene-5-olide, 2- Octene-5-olide, 4-methyl-4-dodecanolide, 4-methyl-4-undecanolide, 4-methyl-4-decanolide, 4-methyl-4-nonanolide, 4-methyl-4-heptanolide, 5-methyl- 5-dodecanolide, 5-methyl-5-undecanolide, 5-methyl-5-decanolide, 5-methyl-5-nonanolide, 5-methyl-5-octanolide, 2-methoxycarbonyl-4-dodecanolide, 2-methoxycarbonyl- 4-undecanolide, 2-methoxycarbonyl-4-decanolide, 2-methoxycarbonyl-4-nona Lido, 2-methoxycarbonyl-4-heptanolide, 2-methoxycarbonyl-5-undecanolide, 2-methoxycarbonyl-5-decanolide, 2-methoxycarbonyl-5-nonanolide, 2-methoxycarbonyl-5-octanolide, 2-allyl -4-undecanolide, 2-allyl-5-decanolide, 2-allyl-4-nonanolide, 2-pentyl-4-undecanolide, 2-pentyl-4-nonanolide, 2-methyl-4-undecanolide, 2-methyl-4 -Nonanolide, 2- (4-hydroxybutyl) -4-undecanolide, 2- (4-hydroxybutyl) -4-nonanolide, 2- (4-hydroxybutyl) -5-decanolide, 5-propyloxy-4-pentanolide , 5-allyloxy-4-pentanolide, 5- (2-hydroxyethoxy) -4-pentanolide, 8-hydroxy-4-octanolide, 6-propyloxy-5-hexanolide, 6-allyloxy-5-hexanolide, 6- ( 2-hydroxye Toxi) -5-hexanolide, 9-hydroxy-5-nonanolide, etc.), ethinomycin, iriflorental, iriparidal, 2'-8-C-glucosyl-7-methylaloesol coumaroyl ester, 2'-8-C -Glucosyl-7-methyl aloesol cinnamoyl ester, chloropyramine, anise extract, aloe extract, itadori (tiger cane root) extract, seaweed extract, shrimp extract, ketsumeishi extract, ogi extract Red-crowned cucumber (Calcon) extract, Onamomi (Temple) extract, Oninoyagara (Tempa) extract, Oyster extract, Ginseng extract, Uyaku extract, Pumpkin extract, Gama (Yellow yellow) extract, Kansui extract, Ginseng extract ) Extract, black moji extract, black spider extract, sisal ) Extract, Saximarum knuckle extract, Cinnamon kaffle extract, Cinnamon ginseng (wei Sensen) extract, Oshima cherry extract, Oyama cherry extract, Bean cherry extract, Takane cherry extract, Kohigan extract, Sato cherry extract, Zion extract Extract, ginseng extract, potato beetle extract, diamondfish extract, camellia extract, toshishi extract, bean pod extract, pear extract, sagebrush extract, yarrow extract, dill extract, beetle extract, beetle extract Extract, human camellia (stone persimmon) extract, Higama (koi) extract, peony extract, floral blanka extract, hamula extract, sagebrush extract, convolvulus extract, Sandalwood extract, Ganoderma lucidum extract, Japanese mackerel extract (Mascus herb) extract, Chinese willow extract, Japanese red willow extract, Japanese willow extract, Japanese black willow extract, Japanese willow extract, Japanese willow extract, Japanese yellow willow extract, Japanese willow extract, Japanese willow extract, Japanese willow extract Timber king willow extract, fox willow extract, dronox extract, bayberry (plum husk) extract, agave mid-autumn, Aono Agave extract, Fukurin Ryu
Turan extract, Mitsumata extract, Aonori extract, Usba aonori extract, Sugiaonori extract, Hiiraaoori extract, Bowuaonori extract, Hosoeda aonori extract, Kombu extract, Macombu extract, Resilib extract, Hosomome comb extract, Mitsuishi kombu extract, Wakame extract, Hirome extract Extracts Giraffe rhinoceros extract, juniper ginseng rhinoceros extract, tsunomata extract, ibottsu no mata extract, malvatsu nomata extract, hirakotojiki , Sugi nori extract, Shikinori extract, Kainori extract, Yakuzusa extract, Urabo shiyahaz extract, Umiuchiwa extract, Ishimozuku extract, Misjikonbu extract, Atsuba misjibu extract, Isomok extract, Nagashimamok extract, Shimomoku extract, Nemosamo extract, Nametamo extract Tatsukuri Extract, Yatsuma Tamoku Extract, Umitorano Extract, Oba Moku Extract, Fusis Mimoku Extract, Haha Moku Extract, Yoremok Extract, Sawtooth Moku Extract, Agaric Sorghum Extract, Mukadenori Extract, Nuraxa Extract, Cronouraxa Extract, Oomkadenori Extract, Oomatsuri Extract Extract, Sponge Extract, Fushitsunagi Extract, Himefushitsunagi Extract, Hirohafutsutsugi Extract, Kurosozo Extract, Co Sozoekisu, Hanesozoekisu, Sozonohanaekisu, brush Saki sawtooth Hiba extract, Thira extract, duck over Tede bruises franc extract, Hamaikaekisu, port Leo Verde extract, Nabo Negro extract, and the like.

(4) Moisturizer Ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol, polypropylene glycol, 1 , 3-Butylene glycol, pentyl glycol, glycerin, erythritol, pentaerythritol, dipentaerythritol, threitol, arabitol, xylitol, ribitol, galactitol, sorbitol, mannitol, lactitol, maltitol, scylitol, laminitol, valienamine, validamine, validatol Polyhydric alcohols such as Beer rubber, benzoin rubber, danmar rubber, guaiac oil, Irish moss, Karaya rubber, tragacanth rubber, carob rubber, quinseed, agar, casein, glucose, galactose, mannose, xylose, fructose, maltose, isomaltose, cellobiose, gentiobiose, trehalose, cordobiose, lamina Libiose, nigerose, cellobiose, sambubiose, neohesperidose, apiose, hammamellose, streptose, hydroxystreptose, dihydrostreptose, 2-methylerythrose or derivatives thereof, 2-methylerythronolactone, mycarose, cladinose, accentose , Arcanose, Oribomai course, Chromose, Ebami course, Vinelose, Nogarose, Billenose, Saccharide such as biose, moenuronic acid, galosamine, cibirosamine, N-acylcansamine, vancosamine, evanitrose, rubranitrose, tetronitrose, pyralose, α-octose, trioxacalcinose, aldogalose, blastominosine, trehalose or derivatives thereof , D-mannosamine and derivatives thereof, primeverose or derivatives thereof, dextrin, gelatin, pectin, starch, carrageenan, carboxymethylchitin or chitosan, and hydroxyalkyl (C2 to C4) to which alkylene (C2 to C4) oxide such as ethylene oxide is added ) Chitin or chitosan, low molecular chitin or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or salt thereof, hyaluronic acid or Its salt, chondroitin sulfate or its salt, 1,3-β glucan, heparin, ethyl cellulose, methyl cellulose, carboxymethyl cellulose, carboxyethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, hydroxypropyl methylcellulose, polyvinyl Water-soluble, such as alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyalkylene oxide such as polyethylene oxide and polypropylene oxide or cross-linked polymers thereof, carboxyvinyl polymer, polyethyleneimine, dermatan sulfate, keratan sulfate Polymers, glycerin fatty acid pyrrolidone carboxylic acid ester Tells, glycerin fatty acid acetylamino acid esters, pyrrolidone carboxylic acid or salt thereof, polyaspartic acid or salt thereof, polyglutamic acid or salt thereof, polylysine or salt thereof, sodium lactate, hydantoin and derivatives thereof, Np-vinylbenzyl-D- Cellobionamide, Np-vinylbenzyl-D-lactone amide, Np-vinylbenzyl-D-maltonamide, Np-vinylbenzyl-D-gluconamide, glucosyloxyethyl methacrylate, galactosyloxypropyl acrylate, mannosyloxyethyl methacrylate, glutamyl Lysine, glutaurine, 1,2,4-butanetriol, caran-3,4-diol, azoxaponin (3-o- [β-D-glucopyranosyl-β-D-glucuronopyranosyl] -sophoradiol, 3- o- [β-D-glucopyranosyl-3-D-glucuronopyranosyl -Soyasapogenol B, 3-o- [β-D-glucopyranosyl-β-D-glucuronopyranosyl] -azuxapogenol, 3-o- [β-D-glucopyranosyl] -28-o- [Β-D-glucopyranosyl-β-D-glucopyranosyl] -dipsogenic acid, 3-o- [α-L-rhamnopyranosyl-β-D-glucopyranosyl-β-D-glucuronopyranosyl] -soya sapogenol B 3-o- [β-D-glucopyranosyl-β-D-glucuronopyranosyl] -29-o- [β-D-glucopyranosyl-β-D-glucopyranosyl] -azuxapogenol, etc.), Aoki ( Aoki) extract, Aogi extract, Kenashia Ogiri extract, Red clover extract, Red clover extract, Akikara pine extract, Aguahe (Amanita coconut) extract, Maruba morning glory extract, Asagao extract, Athira (Shokuyo kanna) Extract, oilseed rape extract, amachazulue Kiss, Amana extract, Ayuyu extract, Hagateto extract, Homogatetope extract, Senninoku extract, Sugimori gateto extract, Hosoa Ogretou extract, Aogateto extract, Haribiyu extract, Aozulan extract, Amaranthus hippochondriax extract , Aristolomeria extract, Arcana extract, Algarrobo extract, Aloe vera extract, Rabbit extract, Yew (first place) extract, Strawberry extract, Carob bean extract, Inazuna (Taylexi) extract, Rice extract, Dog mint extract, sardine tobacco (Iwabuchi) extract, iwahiba extract, sardine pine (roll mushroom) extract, wheat (chibusanoki) extract, duckweed (float) extract, euglena extract, euglena extract ) Extract, Enokitake mushroom extract, eringi extract, pre-lotus eringi extract, Ogata Houken extract, Oogurma (Civil fragrance) extract, Steller's beetle (cereal essence) extract, Oka extract, Okazeri (serpentine) extract, Okra Extract, Onidokoro Extract, Tokoro Extract, Nagadokoro (Hikai) Extract, Ononis Extract, Yuuko Extract, Oyster Extract, Ginseng Extract, Ganohydrangea Extract, Cascara Sagrada Extract, Gypsophila Extract, Panax Ginseng Extract, Caniva Extract, Carnation Extract, Gerbera extract, camouflage (camo duck) extract, color extract, oat extract, karin extract, Kawara Psycho extract, kawajisha extract, kawaranadeshiko (stone bamboo) extract, Ezokawaranadeko (buckwheat, buckwheat) Kiss, Kantara extract, Kikutaniku extract, quinoa extract, cabbage extract, kiwi extract, cucumber extract, gyory extract , Kudzu (Kudzu) extract, Ginseng (Yellow flower) extract, Kupuas extract, Gumbai tuna (Sekimei, Sekimeishi) extract, Kemponashi (Kigushi) extract, Gekkavidin (Monthly beautiful woman) extract, Koolen (Huoren) extract, Coconut extract, Cosmos extract, coconut krill extract, rice oil extract, konjac extract, saffron (banban flower, west safflower) extract, sapodilla extract, sangre degrad (croton) extract, sanchinin carrot (37 ginseng) extract, shea (carite) extract , Cyanoki extract, shiitake extract (shiitake) extract, shiitake Di extract, Hinshimeji extract, Shakashimeji extract, Hatake shimeji extract, Oshiroi shimeji extract, Buna shimeji extract, Honjimeshi extract, Shirotamogitake extract, Shimokurene extract, Saishin extract, Cactus extract, Janohige (bara winter) extract, Shukukonka miso extract, Zouzan hydrangea (Tsuneyama) extract, white-faced butterfly extract, white-leafed adzuki (chicken bone grass) extract, ginkgo biloba (Mizuka, Mizuka flower, Shencho flower) extract, watermelon (Western phoenix) extract, Suzu-Psycho (Xucho cocoon) extract, subhihiyu (horse tooth soap, Horse tooth extract) extract, boiled extract, cherry blossom extract, Japanese apricot extract, Japanese apricot extract, Okinawa aquatic extract, Japanese apricot extract, an antelope extract, a Japanese apricot extract, a Japanese apricot extract (Bush Shukuboku) extract, mallow extract, celery extract, senshinren (Daishinren) extract, Japanese radish (radish) extract, Takasaburo (Boku lotus) extract, Tachidokoro (hikai) extract, dahlia (tenjiku button) extract, tarwi extract, Sengokushi extract, Sojutsu extract, Chankapiedra extract, Tulip extract, Chorogi extract, Tsukuritake (mushroom) extract, Camellia extract, Clover (lacquered licorice) extract, Tonabena (river cut) extract, Corn extract, Corn hair (Southern lash) extract, Toxa (wood band) extract, Torico (crust) extract, Turkish Kyary extract, Solid bean extract, Vertical bean extract (Sword bean) extract, Jujube (Daisen) extract, Navena (interrupted) extract, Nameko extract, Nambang Karamushi (Hemp) Extract, Niosum Ville Extract, Nutzuku extract, Nemum extract, Nebu extract, Nebi extract, Nemurioki extract, Digokubana (community) extract, Nogateto extract, Hylindough extract, Hauchiwa extract, Hauchi bean extract, Papaya extract, Pahalobo extract, Balata rubber extract, Haratake extract, Haratake extract, White oharatake extract , Usukimorinokasa extract, Haran extract, Pariurus (Amanita spp.) Extract, Balsamina (Spirea, bitter gourd) extract, Harindou extract, Handaikai (Yutakakai) extract, Hygurmadori extract, Beet extract, Hiba extract, Sunflower extract, Pepper extract, Himeuzu (Tenpo) extract, Japanese pine bamboo (Kawariharatake, Hiromatsutake) extract, Fuyumushinakusatake (Cycium Cordyceps) extract, Brazilian licorice extract, hazel Extract, loofah extract, diatomaceous earth extract, nettle extract (sparkling) extract, broomweed extract, elder extract, nendo extract, scallop extract, ground scallop extract, spinach (saccharidum, acute kid, pelagic grass) extract, falcon extract Nokirinso (Keiten 37) extract, Jojoba extract, Borage (Lurichisha) extract, Bordeaux extract, Hononiku (meat juju, Taigei) extract, Honsekkok (iron skin stone, Sparrow mountain stone) extract, Maca extract, Macadamia nut extract, Margaret extract, Tamanosen Hallen extract, Kyukon Kinlenka extract, Matatabi (wooden cocoon) extract, Matsukasa extract, Matsuhodo (sardine) extract, Matico (cordon sillo) extract, quince extract, malein (browed mud squid) extract , Manzanya (Andesca Extract) ) Extract, ilex extract, cornflower extract, yacon extract, coconut extract, yab tobacco (crane gourd, tennasei) extract, malonie extract, mokka extract, lily extract, ligan extract, lime extract, rye extract, jackfruit extract, shallot (Palm-white) extract, apple extract, gentian extract, litchi (wedge, toothpick nucleus) extract, forsythia extract, yokuinin extract, minisasaniki extract, chlorella vulgaris extract, chlorella pyrenoid extract, chlorella ellipsoidia ex , Macrocystis pirifera extract, Yuikiri extract, Tosakanori extract, Cyprinus extract, Amakusaori extract, Aoumidro extract, Kawanoori extract, Marimo extract, Motsukihitoe extract, Ezoyahaz extract, Habanori extract, Habanori extract, Watamo extract, Aname extract, Sujime extract Extract, Antokume extract, Tsuruarame extract, Kuroshiome extract, Nekoshikonbu extract, Ainuwakame extract, Chigaiso extract, Ezoi Shige extract, Yabanemoku extract, Trumpet extract, Uganomok extract, Joromoku extract, Hiemonoku extract, Tamanashimok extract, Honda wall extract, Sugi moku extract Bovine Kenori Extract, Susabiori Extract, Akebono Mozuku Extract, Cyprinus Extract, Fusanori Extract, E Banaminohana extract, Hanafnori extract, Itohnori extract, Kaginori extract, Mirin extract, Hosobamyrin extract, Kikutosaka extract, Ezonameshi extract, Ibaranori extract, Kagyi baranori extract, Saidaibara extract, Tatyibara extract, Ogonori extract, Tsurusilamo extract, Honey beetle extract, red clover extract, red ginseng extract, natto fungus culture metabolite, natto extract, loofah water, birch (white birch) or red pine sap, etc.

(5) Cell Activator / Metabolic Activator Vitamin A Group: Retinol or its salts and derivatives thereof (retinyl unsaturated fatty acid esters such as retinyl linoleate, retinyl linolenate, retinyl oleate, retinyl arachidonic acid, etc.), Retinal or a salt thereof and derivatives thereof, dehydroretinal or a salt thereof and derivatives thereof, retinoic acid or a salt thereof and derivatives thereof, retinoic acid analog (4-[[[8- (3,5-dimethylphenyl)- 2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (3-methylphenyl) -2-naphthalenyl) carbonyl] amino] benzoic acid, 4-[[[8- (4-methylphenyl)- 2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[[8- (2-methylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4- [[8- (3,4-Dimethylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2,4-dimethylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid 4-[[[8- (2-Isopropylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-ethylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid 4-[[[8- (2-Fluorophenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-methoxyphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid 4-[[((8-benzyl-2-naphthalenyl) carbonyl] amino] benzoic acid, 4-[(E) -2- (8-phenyl-2-naphthalenyl) propenyl] benzoic acid), retinoic acid derivatives (4 -Hydroxyphenylretinamide), retinoid analogues (4-[[(5,6 -Dihydro-5,5-dimethyl-8-ethyl-2-naphthalenyl) amino] carbonyl] benzoic acid, 4-[[((5,6-dihydro-5,5,8-trimethyl-2-naphthalenyl) amino] carbonyl ] Benzoic acid, 4-[[((5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) amino] carbonyl] benzoic acid, 4-[[((5,6-dihydro-5,5 -Dimethyl-8-ethyl-2-naphthalenyl) carbonyl] amino] benzoic acid, 4-[[((5,6-dihydro-5,5,8-trimethyl-2-naphthalenyl) -carbonyl] amino] benzoic acid, 4 -(E)-[2- (5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) -1-propenyl] benzoic acid, 4-[[((5,6-dihydro-5, 5-dimethyl-8-phenyl-2-naphthalenyl) oxy] carbonyl] benzoic acid, 4-[[((5,6-dihydro-5,5-dimethyl-8-phenyl-2- (naphthalenyl) carbonyl] amino) benzoic acid Acid, 4-[[( 5,6-dihydro-5,5-dimethyl-8-phenyl-2- (naphthalenyl) carbonyl] oxy] benzoic acid, 4-[[5,6-dihydro-5,5-dimethyl-8- (2-fluoro) Phenyl) -naphthalenyl] carbonyl] amino] benzoic acid, 4-[[((5,6-dihydro-5,5,6-trimethyl) -8-phenyl-2- (naphthalenyl) carbonyl] amino] benzoic acid, 4- [[((5,6-dihydro-5,5,7-trimethyl-8-phenyl-2-naphthalenyl) carbonyl] benzoic acid, 4-[[((E)-(5,6-dihydro-5,5-dimethyl -8-phenyl) -2-naphthalenyl] vinyl] benzoic acid, 4-[[[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] sulfamyl] benzoic acid, 4 -[[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl] sulfamyl] carbonyl] benzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8 -Phenyl) -2-naphth Talenyl] ethyl] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] thiocarbonyl] amino] benzoic acid, 4-[[[((5, 6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] methyl] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2 -Naphthalenyl] methyl] oxy] benzoic acid, 4-[[[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthenyl] oxy] methyl] benzoic acid, 4-[[[( 5,6-dihydro-5,5-dimethyl-8- (2,4-dimethylphenyl)]-2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[((5,6-dihydro-5,5 -Dimethyl-8- (4-methylphenyl)]-2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] Ethyl) benzoic acid, 4-[[[[ (5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] sulfamyl] methyl] benzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] methyl] amino] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] amino] thiocarbonyl] benzoic acid, 4- [ [[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] methyl] sulfamyl] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8 -Phenyl-2-naphthalenyl] amino] methyl] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] amino] -2-hydroxybenzoic acid 4-[[[((5,6-Dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] amino] -2-nitrobenzoic acid, 4-[[[((5,6- Dihydro-5,5-dimethyl-8 -Phenyl) -2-naphthalenyl] carbonyl] amino] -2-fluorobenzoic acid, 4-[[[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl] carbonyl] amino]- 2-methoxybenzoic acid, 4-[[[[(5,6-dihydro-5,5-dimethyl-8- (2-naphthalene)]-2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[(5 , 6-Dihydro-8-phenyl-2-naphthalenyl) carbonyl] aminobenzoic acid, 4-[[((5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) carbonyl] amino] -3 4-fluorobenzoic acid, 4-[[((5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) carbonyl] amino] -3-methylbenzoic acid, 4-[[(5,8, 10,10a-tetrahydro-10,10-dimethyl-9-phenyl-2-anthracenyl) carbonyl] amino] benzoic acid, 4-[[((1,1-dimethyl-3-phenyl-1H1-inden-5-yl) Mino] carbonyl] benzoic acid, 4-[(1,1-dimethyl-3-phenyl-1H-inden-5-yl-oxymethyl) benzoic acid, 4- [2- (1,1-dimethyl-3-phenyl) -1H-Inden-5-yl) vinyl] benzoic acid, 4-[(1,1-dimethyl-3-phenyl-1H-indene-5-carbonyl) amino] benzoic acid), carotene or its salts and their derivatives (Carotenoids such as α-carotene, β-carotene, γ-carotene, lycopene, cryptoxanthine, lutein, zeaxanthin, isosexanthine, rhodoxanthine, capsanthin, crocetin), lycopene or a salt thereof and derivatives thereof, vitamin B group: thiamine or a salt thereof As well as their derivatives (thiamine hydrochloride, thiamine disulfide, bisbenchamine, bisivethiamine, thiamine monophosphate disulfide, benfotiamine, Cotyamine, octothiamine, dicetiamine, fursultiamine, prosultiamine, astaxanthin thiamine phosphate diester, etc.), thiamine sulfate, riboflavin or salts thereof and derivatives thereof (flavin adenine dinucleotide, flavin mononucleotide, riboflavin phosphate diester, 1-β-D-ribofuranosyl nicotinamide pyrophosphate diester, 1-β-D-ribofuranosyl nicotinic acid, etc.), pyridoxine or a salt thereof and derivatives thereof (3,4-dipalmitic acid pyridoxine, 3,4 -Pyridoxine dicaprylate, pyridoxine sulfate diester, etc.), pyridoxal or a salt thereof and derivatives thereof, pyridoxamine or a salt thereof and derivatives thereof, cyanocobalamin or a salt thereof and derivatives thereof, cobalamin (methylcobalami) , Adenosylcobalamin, hydroxocobalamin, aquacobalamin, etc.), folic acid or salts thereof and derivatives thereof, nicotinic acid or salts thereof and derivatives thereof, pantothenic acid or salts thereof and derivatives thereof, biotin or salts thereof and derivatives thereof , Choline or a salt thereof and derivatives thereof, inositol or a salt thereof and derivatives thereof, vitamin C group: ascorbic acid or a salt thereof and derivatives thereof, vitamin D group: ergocalciferol or a salt thereof and derivatives thereof, cholecalci Ferrol and its salts and their derivatives (1α-hydroxy-22-[(1-hydroxy-1-methyl) -2-cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanol Calciferol, [1R, 4R] -1α-hydroxy-22-[(1-hydroxy-1-methyl) -2-cyclope Ten-4-yl-oxy] -23,24,25,26,27-pentanorcorecalciferol, [1R, 4S] -1α-hydroxy-22-[(1-hydroxy-1-methyl) -2- Cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanorcorecalciferol, [1S, 4R] -1α-hydroxy-22-[(1-hydroxy-1-methyl) -2- Cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanorcorecalciferol, [1S, 4S] -1α-hydroxy-22-[(1-hydroxy-1-methyl) -2- Cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanorolecalciferol and the like, dihydrotaxosterol or a salt thereof and derivatives thereof, vitamin E group: tocopherol or a salt thereof and derivatives thereof, Tocotrienol or a salt thereof and derivatives thereof, ubiquinone or a salt thereof and derivatives thereof, vitamin K group: phytonadione or Salts thereof, derivatives thereof, menaquinone or salts thereof and derivatives thereof, menadione or salts thereof and derivatives thereof, menadiol or salts thereof and derivatives thereof, vitamin F group: linoleic acid or salts thereof and derivatives thereof, linolenic acid Or salts thereof and derivatives thereof, arachidonic acid or salts thereof and derivatives thereof, carnitine or salts thereof and derivatives thereof, ferulic acid or salts thereof and derivatives thereof, γ-oryzanol or salts thereof and derivatives thereof, orot Acids or salts thereof and derivatives thereof, vitamin P group: rutin or salts thereof and derivatives thereof, eriocitrin or salts thereof and derivatives thereof, hesperidin or salts thereof and derivatives thereof, vitamin L group: anthranilic acid or salts thereof As well as those Conductor, adenylthiomethylpentose or salt thereof and derivatives thereof, vitamin U group: methylmethionine sulfonium chloride or derivative thereof, valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine , Serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine, arginine, ornithine, histidine or a derivative thereof (N-octyloxycarbonyl-β-alanyl-L-histidine, N-dodecyloxycarbonyl -β-alanyl-L-histidine, N- (12-amino-1-oxododecyl) -L-histidine, N-2-ethylhexyloxycarbonyl-β-alanyl-L-histidine hydrochloride, N-hexadecylo Cycarbonyl-β-alanyl-L-histidine, N-octylaminocarbonyl-β-alanyl-L-histidine, N-dodecylaminocarbonyl-β-alanyl-L-histidine, N-dodecylsulfonyl-β-alanyl-L- Amino acids such as histidine, N-dodecylamino-oxalyl-β-alanyl-L-histidine, etc.) and their amino acid derivatives such as sulfate, phosphate, nitrate, citrate, or pyrrolidone carboxylic acid, glycol Α-hydroxy acids such as acid, citric acid, malic acid, tartaric acid, lactic acid, succinic acid, 2-hydroxycarboxylic acids (methyl lactic acid, 2-hydroxybutanoic acid, 2-hydroxypentanoic acid, 2-hydroxyhexanoic acid, 2-hydroxy Hydroxyheptanoic acid, 2-hydroxyoctanoic acid, 2-hydroxynonanoic acid, 2-hydroxydecanoic acid, 2-hydroxyundecanoic acid, α-hydroxylaurin Acid, α-hydroxymyristic acid, α-hydroxypalmitic acid, α-hydroxystearic acid, α-hydroxyarachidonic acid, cerebronic acid, α-hydroxynervonic acid, mandelic acid, benzylic acid, phenyllactic acid, atrolactic acid, 2- ( 4'-hydroxyphenyl) -2-hydroxyethanoic acid, 2- (4'-chlorophenyl) -2-hydroxyethanoic acid, 2- (3'-hydroxy-4'-methoxyphenyl) -2-hydroxyethanoic acid, 2 -(4'-hydroxy-3'-methoxyphenyl) -2-hydroxyethanoic acid, 3- (2'-hydroxyphenyl) -2-hydroxypropanoic acid, 3- (4'-hydroxyphenyl) -2-hydroxypropane Acid, 2- (3 ', 4'-
Dihydroxyphenyl) -2-hydroxyethanoic acid, glyceric acid, erythronic acid, ribbon acid, arabinonic acid, xylonic acid, lyxonic acid, arolic acid, altronic acid, gluconic acid, mannonic acid, gulonic acid, idonic acid, galactonic acid, talon Acid, glucoheptonic acid, galactoheptonic acid, tartronic acid, mucinic acid, etc.), polyhydroxycarboxylic acid or hydroxypolycarboxylic acid (gluconolactone, galactonolactone, glucuronolactone, galacturonolactone, gulonolactone, ribonolactone, sugar lactone) , Pantoyl lactone, glucoheptonolactone, mannonolactone, galactoheptonolactone, etc.), 2-keto acids (glyoxylic acid, methyl 2-ketoethanoate, benzoylformic acid, methyl benzoylformate, ethyl benzoylformate, pheny (Rupyruvic acid, methyl phenylpyruvate, ethyl phenylpyruvate, 2-ketobutanoic acid, 2-ketopentanoic acid, 2-ketohexanoic acid, 2-ketoheptanoic acid, 2-ketooctanoic acid, 2-ketododecanoic acid, methyl 2-ketooctanoate, etc.) , Quinic acid, isocitric acid, tropic acid, tretocanic acid, 3-chlorolactic acid, cerebronic acid, citramalic acid, agaricinic acid, alloyic acid, pantoic acid, lactobionic acid, hexulosonic acid, photosensitizer 301, hinokitiol, pantothenic acid or its Derivatives, allantoin, pentadecanoic acid glycerides, linolenic acid or derivatives thereof, eicosapentaenoic acid or derivatives thereof, docosahexaenoic acid or derivatives thereof, estradiol, ethenylestradiol, antialol or glycosides thereof, rioniresinol or glycosides thereof, rhodede Ndrol or its glycoside, platifironol or its glycoside, lactone compound (D-glucurono-6,3-lactone, α-D-glucoheptonic-γ-lactone, δ-glucuronolactone, α, β -Glucooctonic-γ-lactone, L-glonic-γ-lactone, γ-D-galactonolactone, D-saccharide-1,4-lactone, D-saccharide-3,6-lactone, D-ribonic-γ -Lactone, α-butyrolactone, γ-butyrolactone, α-octanoic lactone, γ-octanoic lactone, nonanoic lactone, γ-valerolactone, D-manninoic-δ-lactone, D-xyloic-δ-lactone, D-arabinoic-δ-lactone, stearoyl-δ-gluconolactone, DL-pantolactone, palmitoyl-DL-pantolactone, etc.), 3-hydroxy-3,4-dicarboxy-1,4-butanolide or derivatives thereof , 6-benzylaminopurine or derivatives thereof, 1,4-diazadicyclooctane, 2,5-dimethylfuran, 2-methylfuran, 2,5-diphenylfuran, 1,3-diphenylisobenzofuran, rutin, tektrigenin 7 -Xylosyl glucoside, captopril, alacepril, lisinopril, enalapril, delapril, benazepril, cilazapril, imidapril, quinapril, trandelapril, perindopril, temocapril, losartan, endothelin, galactomannan saccharide polymer, mucin, trimethylglycan, proteo extract Lactic acid bacteria culture extract, lactic acid bacteria fermented milk extract, bifidobacteria extract, bifidobacteria culture extract, bifidobacteria fermented milk extract, placenta extract, ganoderma extract, spleen extract, thymus extract, yeast extract, Mother culture extract, yeast fermentation extract, filamentous fungus extract, filamentous fungus culture extract, basidiomycete extract, basidiomycete culture extract, bacterial cell disruption extract, bacterial culture extract, cultured human dermal cell disruption extract, Ground yellow) extract, fennel (mushroom) extract, sorghum (barley gourd) extract, barley (barley) extract, oakuri higotai (Zhengzhou leakage, indigo head) extract, komeba hypericum extract, hypericum perforatum extract, holland jelly extract , Dutch Honey Bee Extract, Silkworm Extract, Roman Chamomile Extract, Garcinia Extract, Kawarani Ginseng (Blue Agate) Extract, Kakiran Extract, Quillaja Extract, Kinlan Extract, Ginlan Extract, Calendula Extract, Sakakanelan Extract, Sasabaginran Extract, Sawagurumi (Mountain) (Walnut) extract, shimo Pepper extract, Shajin extract, plum extract, walnut extract, cedar extract, pineapple extract, Chinese cabbage extract, Japanese cypress extract, beech extract, physalis extract, maitake (maiko) extract, misohagi ( Chikuma) extract, Mukuge (Kiso) extract, Mukuroji (prolonged skin) extract, coconut extract, Eucalyptus extract, Yukinoshita (tiger ear grass) extract, Suabisimus extract, Lettuce (Chisha) extract, Aloe extract, Ogon Extract, Tonka Bean Extract, Gentiana Extract, Burdock Extract, Shikon Extract, Carrot Extract, Clam Squirrel Extract, Hop Extract, Yokuinin Extract, Odorikosou Extract, Assembly Extract, Toki Extract, Tokisenka Extract, Achacha Extract, Hypericum Extract, Cucumber Extract, Tachija Cranberry extract, rosemary extract, parsley extract, sandadagusa extract, fukurin amiji extract, guts-comb extract, oyster-comb extract, oni-konbu extract, gohei-comb extract, naga-comb extract, pea-comb extract, prickly-comb extract, rattle extract Rattle extract, Beni Mozuku extract, Hoso Beni Mozuku extract, Kagekinori extract, Ezotosaka extract, Shiramo extract, birch extract, salicylic acid or salts thereof and their derivatives (salicylic acid glucoside, salicylic acid fatty acid ester, salicylic acid alcohol ether, salicylic acid amides, etc.) , Salicyl alcohol or a salt thereof and derivatives thereof, apigenin, ament flavone, salamander extract, udo extract, shishido extract, gasho extract, potato Extract, bovine taxis extract, cuckoo thistle extract, scallion (sheep-root) extract, gymnema sylvesta extract, carrion extract, ginkgo biloba extract, konronka extract, sabrunryo extract, jasmine (matsurika) extract, hollyhock extract, gypsophila extract , Arabidopsis extract, Lily of the valley extract, Souzo extract, Deco extract, Tochu extract, Nagii Kada (Butcher bloom) extract, Teppo cucumber extract, Tokiwa mansaku extract, Nankin goby extract, Niwa urushi extract, Nadeshiko extract, Michiyanagi extract, Japanese willow extract Hemp) extract, yellow willow extract, weeping willow extract, magnolia extract, yah-so-so extract, wakame wisteria extract, leopard cauli extract, ajijigusae Kiss, shellfish extract (cockle extract, green mussel extract, oyster extract, European oyster extract, scallop extract, clam extract, clam extract, bakagai extract, ishi mussel extract, red mussel extract, abalone extract, turban shell extract, bi-extract, etc.).

(6) Antioxidants Ascorbic acid or its salts and their derivatives (magnesium phosphate-L-ascorbate, ascorbyl palmitate, ascorbyl dipalmitate, ascorbyl hydroxyprophosphate, 5-o-α-D -Glucopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate sodium salt, L-ascorbic acid phosphate potassium salt, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate calcium salt, L- Ascorbic acid phosphate aluminum salt, L-ascorbic acid sulfate sodium salt, L-ascorbic acid sulfate potassium salt, L-ascorbic acid sulfate magnesium salt, L-ascorbic acid sulfate calcium salt, L-ascorbic acid sulfate Aluminum salt, L- Scorbic acid sodium salt, L-ascorbic acid potassium salt, L-ascorbic acid magnesium salt, L-ascorbic acid calcium salt, L-ascorbic acid aluminum salt, 6-o-α-D-galactopyranosyl-L-ascorbic acid 2-o-β-D-galactopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate sodium salt, L-ascorbic acid sulfate sodium salt, 6- o-acyl ascorbic acid phosphate sodium salt, 6-o-acyl ascorbic acid phosphate ammonium salt, 6-o-acyl ascorbic acid phosphate isopropanolamine salt, 3-o-isopropyl-L-ascorbic acid, 6 -o-alkyl ascorbic acid phosphate potassium salt, 6-o-alkyl ascorbic acid phosphate calcium salt, 6-o- Rualkylascorbic acid phosphate barium salt, 6-o-alkylascorbic acid phosphate ammonium salt, 6-o-alkylascorbic acid phosphate monoethanolamine salt, 6-o-alkylascorbic acid phosphate diethanolamine salt, 6-o-alkylascorbic acid phosphate triethanolamine salt, 6-o-alkylascorbic acid phosphate monoisopropanolamine salt, 6-o-alkylascorbic acid phosphate diisopropanolamine salt, 6-o-alkyl Ascorbic acid phosphate triisopropanolamine salt, 3-o-glycosyl-L-ascorbic acid, 6-o-β-D-galactopyranosyl-L-ascorbic acid, ascorbic acid phosphate cholesterol ester, palmitic acid L- Ascorbyl, L-ascorbyl isopalmitate, L-ascorbyl dipalmitate, L-ascorbyl diisopalmitate, L-ascorbyl stearate, L-ascorbyl isostearate, L-ascorbyl distearate, L-ascorbyl diisostearate, L-ascorbyl myristate, L-ascorbyl myristate Ascorbyl, dimyristic acid L-ascorbyl, diisomyristic acid L-ascorbyl, 2-ethylhexanoic acid L-ascorbyl, di-2-ethylhexanoic acid L-ascorbyl, oleic acid L-ascorbic acid, 2-o-α-D -Glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α-D-maltotriosyl-L-ascorbic acid, 3-o-α-D-glucosyl- L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α-D-maltotriosyl-L-ascorbic acid, L-ascorbic acid tetraisopalmitate, L -Ascorbic acid tetralauric acid ester, L-ascorbic acid tetra-2-ethylhexanoic acid ester, L-ascorbic acid tetraoleic acid ester, 5,6-isopropylidene-L-ascorbic acid, le, L-ascorbic acid retinol ester , L-ascorbic acid-DL-tocopherol phosphate ester, L-3-o-ethylascorbic acid, L-ascorbic acid tristearate, L-ascorbic acid tripalmitate, L-ascorbic acid trioleate, L-ascorbic acid Triphosphate, 2-o-ascorbyl cinnamate, 2-o-ascorbyl ferrate, 2-o-ascorbyl caffeate, 2-o-ascorbyl synapate, 2-o- [6-palmitoyl ascorbyl] -4'- Acetoxyferrate, DL-α-tocopherol-2-L-ascorbic acid phosphate diester, inositol ascorbate Derivatives, ascorbic acid phosphoramide derivatives, ascorbic acid arbutin conjugates, ascorbyl phosphoryl cholesterol, chromanyl ascorbic acid derivatives, ascorbic acid sialic acid derivatives, etc.), stearates, tocopherols or salts thereof and derivatives thereof (α-tocopherol, β-tocopherol) , Γ-tocopherol, δ-tocopherol, ε-tocopherol, α-tocopheryl retinoate, aminomethylated tocopherol, hydroxymethylated tocopherol, tocopheryl phosphate, tocopherol acetate, tocopherol nicotinate, tocopherol succinate, tocopherol linoleate , Tocopherol orotate, DL-α-tocopheryl glucoside, DL-α-tocopheryl maltoside, DL-β-tocopheryl glucoside DL-β-tocopheryl maltoside, DL-γ-tocopheryl glucoside, DL-γ-tocopheryl maltoside, DL-δ-tocopheryl glucoside, DL-δ-tocopheryl maltoside, D-α-toco Ferryl glucoside, D-α-tocopheryl maltoside, D-β-tocopheryl glucoside, D-β-tocopheryl maltoside, D-γ-tocopheryl glucoside, D-γ-tocopheryl maltoside, D-δ- Tocopheryl glucoside, D-δ-tocopheryl maltoside, L-α-tocopheryl glucoside, L-α-tocopheryl maltoside, L-β-tocopheryl glucoside, L-β-tocopheryl maltoside, L-γ -Tocopheryl glucoside, L-γ-tocopheryl maltoside, L-δ-tocopheryl glucoside, L-δ-tocopheryl maltoside, 1- (sulfoethylamino) -3- (α-tocopheryl-6- Iroxy) propan-2-ol, 1- (carboki Cypropylamino) -3- (α-tocopheryl-6-iroxy) propan-2-ol hydrochloride, S- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] cysteine, S- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] -γ-glutamylcystenylglycine, N- [3- (α-tocopheryl-6-iroxy) -2-hydroxy Propyl] aspartic acid, N- [3- (α-tocopheryl-6-yloxy) -2-hydroxypropyl] glutamic acid, etc.), tocotrienol or a salt thereof and derivatives thereof (α-tocotrienol, β-tocotrienol, γ- Tocotrienol, δ-tocotrienol, tocotrienol acetate, tocotrienol nicotinate, tocotrienol succinate, tocotrienol linoleate, tocotrienol orotate), di Dropyridine derivatives (methyl-3-phenyl-2-propenyl 1,4-dihydro-2,6-dimethyl-4- (3-nitrophenyl) pyridine-3,5-dicarboxylate and its salts), benzochroman derivatives, nor Dihydroguaselectenic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, parahydroxyanisole, propyl gallate, sesamol, sesamolin, gossypol, maritimaine, sulfretin, xanthene-2,7-diols , Caffeoylquinic acids, propolis, carotenoids (α-carotene, β-carotene, γ-carotene, lycopene, lutein, violaxanthin, spiroloxanthine, spheroidene, astaxanthin, etc.), fluorotannin, akebi (wood) extract, Amacha (Amacha) extract, Dutch beetle extract, Orchid extract, kumquat extract, goby extract, geno shoko (old vine) extract, sesame extract, sesame cell extract, sesame extract (genus ginseng) extract, rice bran extract, pomegranate extract, salamander extract, pear extract, daio (daio) extract , Tomato extract, Nanten extract, Noasami extract, Neubara extract, paprika extract, pistachio extract, betel wax extract Ogulma extract, Mao (mao) extract, Mimosa extract, Mebogi extract, Himekuma willow extract, Willow tree deer extract, Cotton smelt (Mitsumoni flower) extract, Chlamydomonas extract, Red-bellied extract, Red-bellied extract, Red-bellied extract, Hypericum extract Eki , White birch extract, salvia extract, nandina fruit extract, ginkgo extract, green tea extract, and the like.

(7) Reactive oxygen scavenger / radical scavenger Superoxide dismutase, catalase, glutathione peroxidase, bilirubin, quercetin, quercitrin, catechin, catechin derivatives, rutin or its derivatives, gallic acid or its salts and derivatives thereof, curcumin or its Salts and derivatives thereof, transferrin, ceruloplasmin, coenzyme Q, uric acid, bilirubin, metallothionein, stilbenegaloyl glycoside (3,5,4'-trihydroxystilbene 4'-o-β-D- (6 "galloyl ) Glucopyranoside, 3,5,4'-trihydroxystilbene 4'-o-β-D- (2 "galloyl) glucopyranoside, etc.), chlorogenic acid phospholipid ester, chlorogenic acid sphingosine ester and derivatives thereof, chlorogenic acid glycolipid ester , Chlorogenic acid sugar ester, black Genolic acid sterol ester, thiazole derivative or salt thereof (2- (3,4-diethoxyphenyl) -4- (3-carboxy-4-hydroxyphenyl) thiazole, 2- (3,4-diethoxyphenyl) -4 -[3-carboxy-4-hydroxy-5- (2-methyl-2-propenyl) phenyl] thiazole and 2- (3,4-diethoxyphenyl) -4- (3-carboxy-4-hydroxy-5- Methylphenyl) thiazole, 2- (3,4-diethoxyphenyl) -4- (3-carboxy-5-methoxyphenyl) thiazole,), hydroxymatilesinol, allohydroxymatilesinol, hydantoin derivative, akaminoki (log) (Wood) extract, Akagasiwa (red buds) extract, Akamino red plant extract, Japanese red plant extract, Japanese red plant root extract, Hydrangea (hydrangea) extract, Abemaki extract, Fig extract, Ginkgo biloba Kiss, Asparagus Extract, Plum (Plum Plum) Extract, Vulture Extract, Estragon Extract, Enju (Plum Blossom, Plum Blossom Rice) Extract, Kashiwa (Plum Tree, Bamboo Leaf) Extract, Gypsophila Extract, Hippopotamus Extract, Birch Extract, Kunugi (樸 Saw) extract, Oleander extract, Satsuma mandarin (Koji, Tachibana, Obenimikan, Fukurikukan, Sagamikoji, Ponkan) extract, Santara extract, Comfrey extract, Sasa (笹) extract, Perilla extract, Aojiso extract, Chilemiso Extract, Catamenzo extract, Peony extract, Japanese oak extract, Japanese oak extract, Crape myrtle extract, Dikoppi extract, Shirakashi extract, White clover (Clover) extract, Horseradish extract, Black tea extract, Green tea extract, Azalea extract, Tencha (Japanese black tea) Extract, te Nidaiyaku Extract, Naniwaibara (Golden Cherry) Extract, Peanut (Peanut) Extract, Kei Extract, Nikkei Extract, Ceylon Nikkei Extract, Yav Nikkei Extract, Keishi Extract, Lotus Blossom Extract, Lotus (Lotus) Extract Japanese cabbage extract Mayoram (Butterfly) extract, Melon extract, Snowy willow extract, Orchid extract, Rakanka extract, Rooibos extract, Naminohana extract, Azusa extract, Basil extract, Mokko (wood scent) extract, etc.

(8) Fat metabolism promoter Phthalazine derivatives (4-ethyl-1- (β-hydroxyethylamino) phthalazine, 4-N-propyl-1- (β-hydroxyethylamino) phthalazine, 4-N-butyl-1- (Β-hydroxyethylamino) phthalazine, 4-N-butyl-1- (β-hydroxypropylamino) phthalazine, etc.), xanthine derivatives (caffeine, theophylline, theobromine, xanthine, aminophylline, choline theophylline, diprofylline, proxyphylline and Oxtriphylline, etc.), Aotsuki-rafuji (wooden candy) extract, thistle extract, aletia thistle extract, pear thistle extract, paddy thistle extract, noel thistle extract, blue thistle extract, cacao extract, elcampuri extract, otsu-rafuji (anti-self) extract, Gajuttsu (莪 朮) extract, Chrysanthemum salmon extract, Kyokyo (桔, Bellflower root) extract, kizuta extract, pepper (pepper) extract, cola acuminata extract, sageo modaka (sawabei) extract, pomelo extract, sanshuyu (yamamaki) extract, tsuba rafuji extract, otsu ヅ rafuji extract, choreimaitake (bamboo shoot) extract, Rhizoma extract, primrose extract, red ginseng extract, ginseng extract (dragon gall) extract, naginata kouju extract, banana extract, puer tea (pure tea) extract, plum extract, boufu (windproof) extract, etc.

(9) UV protective agent / UV absorption accelerator Benzophenone derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid Sodium, dihydroxydimethoxybenzophenone, dihydroxydimethoxybenzophenone-sodium sulfonate, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), 1,2-dihydroxy-4- (2-hydroxyethyl) benzene derivatives (1- (2- ( 4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (6- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) ) Glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (2-acetyl-4- (3,4-dihydroxycinna)) Moyl) -3-rhamnosyl) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (2-acetyl-6- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3, 4-dihydroxybenzene, 1- (2- (4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (6- (4-hydroxy -3-methoxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) -1- Methoxyethyl-3,4-dihydroxybenzene, 1- (2- (4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) -1-hydroxyethyl-3,4-dihydroxybenzene, 1- ( 2- (6- (3,4-Dihydroxycinnamoyl) -3-xylosyl) glucosyl) ethyl-3,4-dihydride Roxybenzene, 1- (2- (3-Allosyl-6- (3-hydroxy-4-methoxycinnamoyl)) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (3-glucosyl-6- (3-hydroxy-4-methoxycinnamoyl)) glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (3-allosyl-6- (3-hydroxy-4-methoxycinnamoyl) glucosyl) Ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (4- (3,4-dihydroxycinnamoyl) glucosyl) ethyl) -3,4-dihydroxybenzene, 1- (2- (3- (3 , 4-dihydroxycinnamoyl) glucosyl) ethyl) -3,4-dihydroxybenzene, 1- (2- (2- (3,4-dihydroxycinnamoyl) glucosyl) ethyl) -3,4-dihydroxybenzene, 1- (2- (6- (3,4-Dihydroxycinnamoyl) glucosyl) ethyl) -3,4-dihydroxybenze Etc.), paraaminobenzoic acid derivatives (paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate, etc.), methoxycinnamic acid derivatives (ethyl paramethoxycinnamate, paramethoxycinnamon) Isopropyl acid, octyl paramethoxycinnamate, 2-ethoxyethyl paramethoxycinnamate, sodium paramethoxycinnamate, potassium paramethoxycinnamate, glyceryl di-2-methoxycinnamate mono-2-ethylhexanoate), anthranilic acid derivatives (such as methyl anthranilate), Urocanic acid derivatives (urocanic acid, ethyl urocanate, etc.), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, Dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives, pyridoxine derivatives, pyridoxal derivatives, pyridoxamine derivatives, amethoflavone, neosacranine, 6-dehydrocarbine, triazine derivatives (4,4'4 " -(1,3,5-triazine-2,4,6-triyltriimino) trisbenzoic acid tris-2-ethylhexyl, etc.), phosphatidyl chromanol derivatives (1,2-dilaurylglycero-3-phospho-2) '-Hydroxymethyl-2', 5 ', 7', 8'-tetramethyl-6'-hydroxychroman, 1,2-dimyristoylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1,2-dipalmitoylglycero-3-phospho-2'-hydroxymethyl-2', 5 ', 7', 8'-tetramethyl-6 ' -Hydroxychroman, 1,2-distealoy Luglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1,2-dialachidonylglycero-3-phospho-2'-hydroxy Methyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1-myristoyl-2-palmitoylglycero-3-phospho-2'-hydroxymethyl-2', 5 ', 7' , 8'-Tetramethyl-6'-hydroxychroman, 1-myristoyl-2-stearoylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'- Hydroxychroman, 1-palmitoyl-2-myristoylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1-palmitoyl-2-stearoyl Glycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1-stearoyl-2-myristoylglycero-3-phospho-2'-hydroxy Methyl-2 ', 5', 7 ', 8'- Tetramethyl-6'-hydroxychroman, 1-stearoyl-2-palmitoylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, etc.) , L-carnosine zinc complex, umbelliferone, esculin, benzyl cinnamate, cinoxalate, oxybenzone, dioxybenzone, octabenzone, soribenzone, benzoresorcinol, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, neoheliopan, chlorophylls, xanthophylls , Escalol, Zinc Oxide, Talc, Kaolin, Ansokcho (benzoic acid) extract, Hub extract, Giant puffer extract, Assamirisiogususa extract, Kawachigusa extract, Kawatake extract, Cypridosa extract, Hassai extract, Spirulina extract, Iaciocio Extract, Funori no Ushike extract, Himegususa extract, Hytengususa extract, Oobusa extract, Chinomori extract, etc.

(10) Astringents Succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc p-phenolsulfonate, potassium aluminum sulfate, resorcin, ferric chloride, tannins (tannic acid, hamellitannin, Acer Gallotannins such as tannin, tetragalloyl glucose, pentagalloyl glucose, hexagalloyl glucose, heptagalloyl glucose, octagalloyl glucose, nonagaroyl glucose, decagalloyl glucose, undecagalloyl glucose, dodecagalloyl glucose , Telimaglandin I, Telimaglandin II, Casuaricin, Peducraggin, Geraniin, Isoturkevin, Granatin A, Granatin B, Kevulinic acid, Keblagic acid, Casuarinin, Nufarin, Procyanidin B-2, Thiasici Elsin tannins such as cincin A and thiacinensin B), red grape extract, red bean extract, altea extract, nettle extract, cascarilla extract, kapoch extract, guarana extract, ezo strawberry extract, Dutch strawberry extract, shrimp strawberry extract , Nawashiro Strawberry Extract, Maple Strawberry Extract, European Raspberry Extract, Kidney Aloe Extract, Hawthorn Extract, Coustella Hakka Extract, Cowberry (Etsutachibana) Extract, Cola Vera Extract, Sugarcane Extract, Sinah Honoki Extract, Honeysuckle Extract Q) Extract, larch extract, elder extract, dandelion extract, centalium extract, white dandelion extract, mud dandelion extract, cranberry extract, tsurutsia Shrimp Extract, Teuchigurumi Extract, Tormentilla Extract, Novara Extract, Buttercup Extract, Hagoromogusa Extract, Castor Extract, Grape Extract, Prunes Extract, Veronica Extract, Bisnaga Extract, Bilberry Extract, Mansuguru Extract, Mitsugashi Extract, Myrrh Extract, Melissa Extract, Mansaku Extracts, Doroyanagi Extract, Latania (Clamelia) Extract, Lemon Extract, Daisy Extract, etc.

(11) Anti-inflammatory agent / interleukin production inhibitor / histamine release inhibitor quinolinone derivative, dibenzooxepin derivative, thiotroposin, phthalimide derivative, flurbiprofen, felbinac, bufexamac, suprofen, 1,4-diphenylpropylpiperazine derivative , Carxin compounds, chromanol glycosides (2- (α-D-glucopyranosyl) methyl-2,5,7,8-tetramethylchroman-6-ol), ictamol, indomethacin, kaolin, diphenhydramine hydrochloride, d-camphor, DL-camphor, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, diphenhydramine hydrochloride, clemastine fumarate, cyproheptadine hydrochloride, prometa hydrochloride , Piperazine derivatives, α-D-phenylglycoside derivatives, glycyrrhizic acid or its salts and derivatives thereof (α-glycyrrhizic acid, β-glycyrrhizic acid, α-glycyrrhizic acid methyl ester, β-glycyrrhizic acid methyl ester, α-glycyrrhizin Trisodium acid, monopotassium α-glycyrrhizinate, dipotassium α-glycyrrhizinate, monoammonium α-glycyrrhizinate, trisodium β-glycyrrhizinate, monopotassium β-glycyrrhizinate, dipotassium β-glycyrrhizinate, monoammonium β-glycyrrhizinate ), Glycyrrhetinic acid or salts thereof and derivatives thereof (α-glycyrrhetinic acid, β-glycyrrhetinic acid, stearyl of α-glycyrrhetinic acid, stearyl of β-glycyrrhetinic acid, pyridoxine of α-glycyrrhetinic acid, β-glycyl Pyridoxine retinoate, glyceryl α-glycyrrhetinate, glycerin β-glycyrrhetinate, disodium 3-succinyloxyglycyrrhetinate, etc.), mefenamic acid, phenylbutazone, ibuprofen, ketoprofen, allantoin, calcium pantothenate, pantothenyl ethyl ether, etc. Panthenol or salts thereof and derivatives thereof, ε-aminocaproic acid, diclofenac sodium, tranexamic acid or derivatives thereof (trans-4-benzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-nitrobenzyloxycarbonylaminomethylcyclohexane) Carboxylic acid, trans-4-p-chlorobenzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-bromobenzyloxycarbonylaminomethyl Cyclohexanecarboxylic acid, trans-4-m-chlorobenzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-methoxybenzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-methylbenzyloxycarbonylaminomethylcyclohexane Carboxylic acid, sodium trans-4-benzyloxycarbonylaminomethylcyclohexanecarboxylate, ammonium trans-4-p-nitrobenzyloxycarbonylaminomethylcyclohexanecarboxylate, potassium trans-4-p-chlorobenzyloxycarbonylaminomethylcyclohexanecarboxylate Trans-4-p-bromobenzyloxycarbonylaminomethyl potassium cyclohexanecarboxylate, trans-4-m-chlorobenzyloxycarbonylaminomethyl Calcium cyclohexanecarboxylate, magnesium trans-4-p-methoxybenzyloxycarbonylaminomethylcyclohexanecarboxylate, trans-4-p-methylbenzyloxycarbonylaminomethylcyclohexanecarboxylic acid monoethanolamine, trans-4-t-butyloxy Carbonylaminomethylcyclohexanecarboxylic acid, trans-4- (2-phenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (p-biphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (3, 5-Dimethoxyphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (p-methylphenylisopropyloxycarbonylaminomethyl) cyclohexa Carboxylic acid, sodium trans-4-t-butyloxycarbonylaminomethylcyclohexanecarboxylate, potassium trans-4- (2-phenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylate, trans-4- (p-biphenylisopropyloxycarbonylamino) Methyl) calcium cyclohexanecarboxylate, trans-4- (3,5-dimethoxyphenylisopropyloxycarbonylaminomethyl) magnesium cyclohexanecarboxylate, trans-4- (p-methylphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid monoethanolamine , Trans-4- (9-fluorenylmethyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4-methylsulfonylethyloxycarbonylaminomethyl Cyclohexanecarboxylic acid, sodium trans-4- (9-fluorenylmethyloxycarbonylaminomethyl) cyclohexanecarboxylate, potassium trans-4-methylsulfonylethyloxycarbonylaminomethylcyclohexanecarboxylate, trans-4- (pyridine-4 '-Methyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (2,2,2-trichloroethyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (2-trimethylsilylethoxycarbonylaminomethyl) cyclohexanecarboxylic acid Potassium, sodium trans-4- (pyridine-4'-methyloxycarbonylaminomethyl) cyclohexanecarboxylate, trans-4- (2,2,2-trichloroethyloxycarbonylaminomethyl) cyclohexanecarboxylic acid Potassium, trans-4- (2-trimethylsilylethoxycarbonylaminomethyl) cyclohexanecarboxylate, etc.), sulfatide, astaxanthin fatty acid diester (astaxanthin dilaurate, astaxanthin dimyristate, astaxanthin dipentadecanoate, astaxanthin dipalmitate) Ester, astaxanthin dipalmito oleate, astaxanthin diheptadecanoate, astaxanthin dielaidate, astaxanthin diricinoleate, astaxanthin petrolinate, astaxanthin vacsenate, astaxanthin eleostearate, astaxanthin punicin Acid ester, astaxanthin ricin Acid ester, astaxanthin parinaric acid ester, astaxanthin gadoric acid ester, astaxanthin 5-eicosenoic acid ester, astaxanthin 5-docosenic acid ester, astaxanthin cetoric acid ester, astaxanthin erucic acid ester, astaxanthin 5,13-docosadienoic acid ester, astaxanthin Ceracholate, Astaxanthin Decenoate, Astaxanthin Steringate, Astaxanthin Dodecenoate, Astaxanthin Dioleate, Astaxanthin Distearate, Astaxanthin Dieicosapentaenoate, Astaxanthin Didocosahexaenoate, Astaxanthin Dilinoleate, Astaxanthin Dilinolenic acid es , Astaxanthin diarachidonic acid ester, etc.), astaxanthin diglycerophosphate (astaxanthin diglycerophosphate, astaxanthin lyserophosphate palmitic acid, astaxanthin lyserophosphatidylcholine palmitate, astaxanthin lyserophosphatidylcholine DHA, astaxanthin lysephrophosphati Diluinositol palmitic acid, astaxanthing lyserophosphatidylinositol DHA, astaxanthing lyserophosphatidylinositol linoleic acid, astaxanthing lyserophosphatidylcholine linoleic acid, steviol glycoside, benzimidazole derivative (1- (2-ethoxyethyl) -2- [1- (2- (4- (1- (4,4-Dimethyl-2-oxazolin-2-yl) -1-methylethyl ) Phenyl) ethyl) piperidin-4-yl] -1H-benzimidazole, 2- [4- (2- (4- (1- (2-ethoxyethyl) benzimidazol-2-yl) piperidin-1-yl) Ethyl) phenyl] -2-methylpropanoic acid, ethyl 2- [4- (2- (4- (1- (2-ethoxyethyl) benzimidazol-2-yl) piperidin-1-yl) ethyl) phenyl]- 2-methylpropanate, 1- (2-ethoxyethyl) -2- [1- (2- (4- (1,1-dimethyl-2-hydroxyethyl) phenyl) ethyl) piperidin-4-yl] -1H -Benzimidazole, 1- (2-hydroxyethyl) -2- [1- (2- (4- (1- (4,4-dimethyl-oxazolin-2-yl) -1-methylethyl) phenyl) ethyl) Piperidin-4-yl] -1H-benzimidazole, 2- [4- (2- (4- (1- (2-hydroxyethyl) benzoimidazol-2-yl) piperidin-1-yl) ethyl) phenyl]- 2-methyl Lopanic acid etc.), alanine derivatives or salts thereof (N- {3-isopentyl-4-methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H-thiazoline-5-carbonyl} -L Alanine, N- {3-isopentyl-4-methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H-thiazoline-5-carbonyl} -2-methylalanine, N- {3-isopentyl -4-methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H-thiazoline-5-carbonyl} -N-methyl-L-alanine), thiazoline derivatives or salts thereof (3-isopentyl) -4-methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H-thiazoline-5-carboxylic acid, 4-isobutyl-3-methyl-2- [4- (3-trifluoromethyl) Benzamido) benzoylimino] -3H-thiazoline-5-carboxylic acid) , Chlorpheniramine maleate, diphenhydramine hydrochloride, diphenylpyraline hydrochloride, carbinoxamine maleate, hydrocortisone butyrate, sulfated acid mucopolysaccharide or salt thereof, sulfated dextran or salt thereof, licorice extract, sicon extract, age extract, propolis, eye ( (Aiba) extract, Asenyaku (Asen Yaku) extract, Avocado extract, Amado Koro (Tamatake) extract, Amigasayuri extract, Baimo (shellfish) extract, Igakozolina (Gall head) extract, Ibukitorano extract, Turmeric (depressed gold) extract , Echinacea (Prunus japonicus) extract, Oren (Yelen) extract, Oguruma (turned over) extract, Hypericum (brutish cut grass) extract, Oniguri extract, Orange extract, Cassia extract, Kamiyatsu (weed) extract, Kawamidori extract, Kawamomogi )extract Watercress extract, Kenashi sartorini rose (Tsumago, Yamakage) extract, Gentianana extract, Koki Sekkokoku extract, Kouhon (Kakimoto, Karatsumoto) extract, Koryokyo (Kora bonsai) extract, Gosho strawberry (covered bonsai) extract, Saihailan extract, Cherry extract, Salvia (sage) extract, squirrel extract, linden extract, salamander extract, indian sea bream extract, shukushamitsu (sand seed, shredded sand) extract, juzudama extract, white minten (southern tenseed) extract, squirrel squirrel extract, natto Extract, Achillea millefolium (milfoil) extract, Hirosanega extract, Takasago Gurihigotai (Southeast Indigo Sashimi) extract, Takarabi extract (Tsubaki spinach) extract, Tachikakuso (Marika) extract, Tamazaki tsumugi rafu extract, Tonin extract, Chigaya Eki , Toga (winter coconut) extract, Dokudami (10 medicines) extract, Parsley (Dutch jelly) extract, Hanabishi (shitsuri, shishitsuri) extract, Hamasge (kotsuko) extract, Hishi (hijimi) extract, belude oyster extract, Fuyukazura ( (South rattan) extract, bundo (mung bean) extract, sandalwood extract, butcher bloom extract, pansy extract, Hosoba Abragik (bitter jelly) extract, Mizurutennansho (Tennansei) extract, pheasant (fruit berry) extract, miracle fruit extract, mulberry extract, Peach (Peach) Extract, Cornflower Extract, Willow Willow Extract, Mistletoe (willow parasite) Extract, Yabukouji (Purple Gold Beef) Extract, Sagebrush Extract, Mugwort (Bamboo Leaf) Extract, Rosemary (Mannenrou) Extract, Japanese Yellow-bellied Extract, Yellow Jusmo Extract, Tamajuzumo extract, Mizojuzumo extract, Urushi Gusa extract, Quercus gulsa extract, Sardine beard extract, Red mushroom extract, Togemoku extract, Aqaba extract, Maruba red mushroom extract, Scallop extract, Dulse extract, Yuna extract, Belladonna extract, Hoonoki extract, Haruni extract (skin peel, white skin, maple leaf) extract, Aozuzuran Extracts, Sakaneran extract, Sasabagin orchid extract, Husambird (including varieties and origins) extract, etc.

(12) Anti-seborrheic agent Chroman derivatives, pyridoxine or salts thereof and derivatives thereof, pyridoxal or salts thereof and derivatives thereof, pyridoxamine or salts thereof and derivatives thereof, sulfur, Asa (Asakojin) extract, Odorikosou (continuous) ) Extract, Dutch mustard (watercress) extract, valerian extract (valerian root) extract, clematis extract, bear sebacekis, savonsou extract, rosewood extract, horse chestnut extract, soybean (soybean) extract, eucalyptus (marigold) extract, potato extract, Yamano potato extract, Nosenhalen extract, Fukitan popo (Section winter flower, Sect winter winter leaf) extract, Yabugarashi extract, Giant kelp extract, Hijirimen extract, Proboscis extract, Haius banori extract, etc.

(13) Antibacterial agent Acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or hydrolyzate thereof, alkyldiaminoethylglycine chloride solution, triclosan, sodium hypochlorite, chloramine T, salami powder, iodine Compound, iodoform, 1-alkylcarbapenem compound, N-substituted azepane derivative or salt thereof, sorbic acid or salt thereof, propionic acid or salt thereof, salicylic acid or salt thereof, dehydroacetic acid, parahydroxybenzoic acid ester, 2-keto -3-deoxyoctanoic acid fatty acid ester, inositol deoxy derivatives (such as quercitol), inositol unsaturated derivatives (such as chonditol), inositol dimethyl ether, methyl inositol, inositol methyl ether Inosamine, deoxyinosadiamine, shikimic acid, quinic acid, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p-chloro-m-xylenol, p-chloro-m-cresol, thymol , Phenethyl alcohol, o-phenylphenol, Irgasan CH3565, halocarban, hexachlorophene, chlorohexidine, ethanol, methanol, isopropyl alcohol, benzyl alcohol, ethylene glycol, propylene glycol, 2-phenoxyethanol, 1,2-pentanediol, zinc pyridione , Chlorobutanol, isopropylmethylphenol, elemol, vetiverol, patchouli alcohol, nonionic surfactant (polyoxyethylene lauryl ether, polyoxyethylene Nonylphenyl ether, polyoxyethylene octylphenyl ether, etc.), amphoteric surfactant, anionic surfactant (sodium lauryl sulfate, lauroyl sarcosine potassium, etc.), cationic surfactant (cetyltrimethylammonium bromide, benzalkonium chloride, chloride) Benzethonium, methyl rosaniline chloride), formaldehyde, hexamine, brilliant green, malachite green, crystal violet, germal, photosensitizer 101, photosensitizer 201, photosensitizer 401, N-long chain acyl basic amino acid derivatives and acid addition salts thereof , Zinc oxide, hinokitiol, propolis, cucumber extract, agi extract, asunalo extract, alpinia extract, katsudai (suzukuku) extract, Inubilu extract Extract鈎) Extract, Kahoku Salamander (蜀椒) Extract, Chamomile Extract, Kinakiki Extract, Red linden extract, Yellow Spider Extract, Caraway Extract, Betel Extract, Kumazasa Extract, Cranberry Extract, Grapefruit Extract, Celosia (Chicken Flower, Chicken Crown) ) Extract, bay bay laurel extract, Koushinbara (monthly flower) extract, copaiba balsam extract, mountain cherry extract, ed pear extract, Miyaza cherry extract, Yoshino cherry extract, Kasami cherry extract, Kanza cherry extract, sugar beet Extract, Sarasinashouma (Hemp) extract, Shimushi (Mikoshi) extract, white birch extract, cinnamon extract, sorrel (acid mimic) extract, dandelion extract, Nezu (Pine pine) extract, Japanese mint extract, Japanese wild mint extract, Soka ( (Grass) extract, onion extract, chicory extract, ginseng extract, tsuruna extract, tokon extract, leek extract, leek extract, peach extract, patchouli extract, ganbanana ( Sarcophagus, vine rosacea extract, cypress extract, pimenta extract, cypress extract, white-butterfly extract, blackberry extract, hop extract, makuri (marine herb) extract, magnolia sprenger extract, mizokakushi (half) Lotus) extract, bee extract, purple (purple) extract, moso bamboo extract, Pokeweed (commercial and commercial) extract, yucca extract, euglena extract, lavender extract, forsythia extract, syringen extract, prunus nomata extract, tochaka (yahazuzumata) extract, red-bellied extract, anaaosa extract, human rush extract, hirohano Human rush extract, Ushiro rush extract, Iroro extract, Ishige extract, Alame extract, Tamai taki extract, Tambanori extract, Katanori extract, Sakuranori extract, Fujimatsumo extract, Kawamozuku extract, Aokawa Mozuku extract, Himekawa Mozuku extract, Yakuchi (Yoshichi) extract, etc.

(14) Blood flow promoter / vascular stimulant Tocopherol or its salt and derivatives thereof, tocotrienol or its salt and derivatives thereof, cephalanthin, carpronium chloride, eugenol derivatives (acetyl eugenol, methyl eugenol, methyl isoeugenol, ethyl eugenol, ethyl Isoeugenol, eugenol salicylate, etc.), minoxidil, chili pepper tincture, nonyl acid vanillamide, cantalis tincture, ginger tincture, peppermint oil, L-menthol, camphor, benzyl nicotinate, cinnarizine, trazoline, acetylcholine, verapamil, ictamol, α- Borneol, cyclandelate, nonyl acid wallenyl amide, capsaicin, gingerone, assembly extract, garlic extract, carrot extract, aloe exhaust , Gentiana extract, Toki extract, Ashitaba (tomorrow) extract, Arnica extract, Yukiyara (Sanriku) extract, Hime wikyou extract, Citrus unshiu (Chen skin) extract, Toucan beetle (coconut) extract, Oyster extract, Kaki extract, Kina extract, Ginseng extract, pine moth (horse whip grass) extract, kubijinsou extract, kohone (river bone) extract, burdock (beef bowl, beef coconut) extract, scallop (mountain curd) extract, syringen extract, ginger (ginger) extract, ginger (ginger)菖蒲, Sone) extract, Hawthorn extract, Seburi (Daiyaku) extract, Daidai (orange peel) extract, Tanjin (dansang) extract, Thyme extract, Chikutsutsuninjin (Takebushi ginseng) extract, Tsurudokudami (what neck 烏) extract, Tsurunjinjin (Yotei ginseng) extract, chili pepper (banban) extract, toki (tokiwa) extract, red pepper Mimochi (Sadako) extract, Natsumikan extract, elderberry (bone graft) extract, hazelnut (coconut) extract, ashidokoro (roth root) extract, mint (light load, thin load leaf) extract, Hamabou Fu (hama bream) extract, Higotai extract, Fujimodoki ( Clover cherry tree, strawberry flower) extract, black currant extract, bodaiju (bamboo tree) extract, merirot extract, yuzu extract, wintersweet extract, bay jelly extract, hibiscus extract, rosehip extract, etc.

(15) Antiandrogens Follicular hormones (estrone, estradiol, ethinyl estradiol, etc.), isoflavones, oxendron, 4 ', 5,7-trihydroxy-8-prenylflavanone, 4', 5,7-trihydroxy-8-prenyl Flavone, 3,3 ′, 4 ′, 5,7-pentahydroxy-8-prenylflavone, nicorandil, cyclosporic acid and the like.

(16) Inhibitors of structural proteolytic enzymes (malastase, elastase, collagenase, keratin protease, serine protease, integrin degrading enzyme, involucrin degrading enzyme, filaggrin degrading enzyme, laminin degrading enzyme, fibronectin degrading enzyme, proteoglycan degrading enzyme) / Structural proteolytic enzyme expression inhibitor Adenine derivatives (butanetriol-9-adenine and its phosphate adduct, propanediol-9-adenine and its phosphate adduct, pentanetriol-9-adenine and its phosphate adduct, etc. ), Carbostyril derivatives or salts thereof, dicarboxylic acids (glutaric acid, adipic acid, pimelic acid, suberic acid, azelaic acid, sebacic acid, 1,9-nonamethylenedicarboxylic acid, 1,10-decamethylenedicarboxylic acid), rosuma Acid, ursolic acid, oleanolic acid, hydroxamic acid derivative, esculetin derivative, anthocyanidins, nordihydroguaiaretech acid, 20-carboxy-16-hydroxy-21-nor-5 α-7,9 (11) -lanostadien- 3,24-dione, ubiquinone, plataquinone, yuglone, shikonin, quinizarin, alizarin, abietin, levopimar, betulin, α-amylin, catechin compounds (catechin, epigallocaequine, epigallocatechin gallate, epicatechin, epicatechin gallate, catechin ram Nopyranoside catechin, etc.), diisopropyl fluorophosphate, (2R, 6R) -2,6-dihydroxy-4- (tert-butyldimethylsilyloxy)-(3Z) -heptene-1,7-dicarboxylate, N, N'-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R) -2,6-dibenzyloxy-4-hydro Siheptanedicarboxylic acid-1,7-diamide, (2R, 6R) -2,6-dihydroxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylate, (2R, 6R) -2 , 6-Dibenzyloxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylate, (2R, 6R) -2,6-dibenzyloxy-4- (tert-butyldimethylsilyloxy) ) Heptane-1,7-dicarboxylic acid, N, N′-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R) -2,6-dibenzyloxy-4- ( tert-Butyldimethylsilyl) oxyheptane-1,7-dicarboxylic acid diamide, N, N'-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R) -2,6- Dibenzyloxy-4-hydroxyheptane-1,7-dicarboxylic acid diamide, N, N′-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R) -2,4, 6-trihydroxyheptane-1,7-dicarboxylic acid diamide, N, N'-bis [(1S, 2R) -2- Droxyindan-1-yl]-(2S, 6S) -2,6-dibenzyloxy-4-hydroxyheptane-1,7-dicarboxylic acid diamide, (2S, 6S) -2,6-dihydroxy-4- (tert -Butyldimethylsilyloxy)-(3Z) -heptene-1,7-dicarboxylate, (2S, 6S) -2,6-dihydroxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylic acid Dimethyl acid, (2S, 6S) -2,6-Dibenzyloxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylate, (2S, 6S) -2,6-dibenzyloxy -4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylic acid, N, N'-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2S, 6S) -2 , 6-Dibenzyloxy-4- (tert-butyldimethylsilyl) oxyheptane-1,7-dicarboxylic acid diamide, N, N'-bis [(1S, 2R) -2-hydroxyindan-1-yl]- (2R, 6R) -2,6-Dibenzyloxy-4-hydroxy Heptane-1,7-dicarboxylic acid diamide, 3-[[4- (4-fluorophenoxy) -benzenesulfonyl]-(1-hydroxycarbamoylcyclopentyl) -amino] -propionic acid, 4- [4- (4-fluoro Phenoxy) -benzenesulfonylamino] -tetrahydropyran-4-carboxylic acid hydroxyamide, 4- [4- (4-chlorophenoxy) -benzenesulfonylmethyl] -tetrahydropyran-4-carboxylic acid hydroxyamide, 3-[[4 -(4-Fluorophenoxy) -benzenesulfonyl]-(1-hydroxycarbamoylcyclobutyl) -amino] -propionic acid, 4- (4'-chlorobiphenyl-4-yl) -2- [2- (1,3 -Dioxo-1,3-dihydroisoindol-2-yl) -ethyl] -4-oxobutyric acid, {1- [4- (4-fluorobenzyloxy) -benzenesulfonyl] -2-hydroxycarbamoylpiperidine-3- Il -Carbamate isopropyl ester, 2- [4- (4-fluorophenoxy) -benzenesulfonylamino] -N-hydroxy-2-methylfuropionamide, 3- [4- (4-fluorophenoxy) -benzenesulfonyl]- 2, N-dihydroxyfuropionamide, 3- (4-phenoxybenzenesulfonyl) -7-oxabicyclo [2.2.1] heptane-2-carboxylic acid hydroxyamide, (4-benzylbenzyl)-[2- (2, 2-Dimethyl-1-methylcarbamoylpropylcarbamoyl) -4- (4'-fluorobiphenyl-4-yl) -butyl] -phosphinic acid, 2-amino-3- [4- (4-fluorophenoxy) -benzenesulfonyl ] -N-Hydroxypropionamide, and N-hydroxy-2- (4-phenylpiperidine-1-sulfonyl) -acetamide, Iris japonicum extract, Nepenthes extract Li (Banaba) extract, Omi hawthorn extract, Hawthorn (Yamako) extract, Calahoo (Park) extract, Guava extract, Shazenso extract, Rose rose extract, Hypericum perforatum extract, Octopus (breeding) extract, Hinata tadpole (cow knee) Extract, Honoki (Japanese Kobak, Park) Extract, American Grape Extract, European Grape Extract, Yama Grape Extract, Mandarin Extract, Mishima Psycho (Shibahu) Extract, Ogon Extract, Hypericum Extract, Clara Extract, Mulberry Extract, Keihi Extract, Genpachi Extract, Comfrey extract, salvia extract, elderberry extract, bodaiju extract, button pi extract, Aozulan extract, sakaneran extract, sasabagin orchid extract, swanbird (including varieties and origins) extract, etc.

(17) Structural protein synthesis promoter Ethanolamine derivative, pentoxyphyllin, serine derivative, geraniol, crocetin, methyl 4- (2-ethylhexyloxy) -2-hydroxybenzoate, 2-hydroxy-4- (3,5, 5-Trimethylhexyloxy) methyl benzoate, methyl 4-cyclohexylmethoxy-2-hydroxybenzoate, methyl 4- (2-cyclohexylethoxy) -2-hydroxybenzoate, 4- (3,7-dimethyl-6-oct Methyl tenenyloxy) -2-hydroxybenzoate, ethyl 3- (2-ethylhexyloxy) -5-hydroxybenzoate, methyl 5- (2-ethylhexyloxy) -2-hydroxybenzoate, 2-hydroxy-5- ( 3,5,5-Trimethylhexyloxy) methyl benzoate, methyl 5- (2-cyclohexylethoxy) -2-hydroxybenzoate, methyl 4-N-hexyloxy-2-hydroxybenzoate 2-methyl-4-N-octyloxybenzoate, methyl 4-N-decyloxy-2-hydroxybenzoate, methyl 5-N-hexyloxy-2-hydroxybenzoate, 4- (2-ethylhexyloxy) ) -2-hydroxybenzoic acid, 2-hydroxy-4- (2,5,5-trimethylhexyloxy) benzoic acid, 4-cyclohexylmethoxy-2-hydroxybenzoic acid, 4- (2-cyclohexylethoxy) -2- Hydroxybenzoic acid, 4- (3,7-dimethyl-6-octenyloxy) -2-hydroxybenzoic acid, 3- (2-ethylhexyloxy) -5-hydroxybenzoic acid, 5- (2-ethylhexyloxy)- 2-hydroxybenzoic acid, 5- (2-ethylhexyloxy) -2-hydroxybenzoic acid, 2-hydroxy-5- (3,5,5-trimethylhexyloxy) benzoic acid, 5- (2-cyclohexylethoxy)- 2-hydroxybenzoic acid, 4-N-hexyloxy-2-hydride Roxybenzoic acid, 5-N-hexyloxy-2-hydroxybenzoic acid, 2-hydroxy-4-N-octyloxybenzoic acid, 4-N-decyloxy-2-hydroxybenzoic acid, N- (2-hydroxyethyl) -4- (2-ethylhexyloxy) -2-hydroxybenzamide, N-ethyl-4- (2-ethylhexyloxy) -2-hydroxybenzamide, 2-acetoxy-4-cyclohexylmethoxybenzoic acid, 4- (2-ethylhexyl) Sodium oxy) -2-hydroxybenzoate, methyl 4-{(2E) -3,7-dimethyl-2,6-octadienyloxy} -2-hydroxybenzoate, 4-{(2E) -3,7 Ethyl 3-dimethyl-2,6-octadienyloxy} -2-hydroxybenzoate, ethyl 5-{(2E) -3,7 dimethyl-2,6-octadienyloxy} -2-hydroxybenzoate, 3 -{(2E) -3,7-dimethyl-2,6-octadienyloxy} -2-hydroxybenzoate, 3-{(2E) -3,7-dimethyl Ethyl 2,6-octadienyloxy} -5-hydroxybenzoate, ethyl 4-{(2E) -3,7-dimethyl-2,6-octadienyloxy} -3-methoxybenzoate, 4 -{(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy} -2-hydroxybenzoic acid methyl 4-{(2E) -3,7-dimethyl-2, 6-octadienyloxy} -2-hydroxybenzoic acid (2E) -3,7-dimethyl-2,6-octadienyl, 4-{(2E) -3,7-dimethyl-2,6-octadienyloxy } -2-hydroxybenzoic acid, 5-{(2E) -3,7-dimethyl-2,6-octadienyloxy} -2-hydroxybenzoic acid, 3-{(2E) -3,7-dimethyl- 2,6-octadienyloxy} -2-hydroxybenzoic acid, 3-{(2E) -3,7-dimethyl-2,6-octadienyloxy} -5-hydroxybenzoic acid, 2-hydroxy-4 -{(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy} benzoic acid, 4-{(2E) -3,7-dimethyl-2,6-octadi Nyloxy} -3-methoxybenzoic acid, 2-acetoxy-4-{(2E) -3,7-dimethyl-2,6-octadienyloxy} benzoic acid, N- (2-hydroxyethyl) -4- { (2E) -3,7-dimethyl-2,6-octadienyloxy} -2-hydroxybenzamide, 4-{(2E) -3,7-dimethyl-2,6-octadienylamino} -2- Hydroxybenzoic acid, dimethyl-2,6-octadienyloxy} benzoic acid, N- (2-hydroxyethyl) -4-{(2E) -3,7-dimethyl-2,6-octadienyloxy}- 2-hydroxybenzamide, 4-{(2E) -3,7-dimethyl-2,6-octadienylamino} -2-hydroxybenzoic acid, 3-dodecyloxybenzoic acid, 3- (12-hydroxydodecyloxy) Benzoic acid, 4-dodecyloxybenzoic acid, 4- (12-hydroxydodecyloxy) benzoic acid, 3- (12-hydroxyoctadecyloxy) benzoic acid, 4- (12-hydroxyoctadecyloxy) Benzoic acid, 3- (11-hydroxyundecyloxy) benzoic acid, 4- (11-hydroxyundecyloxy) benzoic acid, 3-[(2E) -3,7-dimethyl-2,6-octadienyloxy ] Benzoic acid, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] benzoic acid, 3-[(2E, 6E) -3,7,11-trimethyl-2,6, 10-dodecatrienyloxy) benzoic acid, 4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] benzoic acid, 4- [3,7-dimethyl- 9- (2,6,6-trimethyl-1-cyclohexen-1-yl) -2,4,6,8-nonatetraenyloxy] benzoic acid, 4- [3,4-dihydro-2,5,7 , 8-Tetramethyl-2- (4,8,12-trimethyltridecyl) -2H-1-benzopyran-6-oxy] benzoic acid, 4-[(2E, 6E) -3,7,11-trimethyl- 2,6,10-dodecatrienyloxy] benzamide, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] benzamide, 4- (2-methyl-2-butenyl Oxy) benzamide, 4- (2-ethylhexyloxy) benzamide, 4-dodecyloxybenzamide, 4- (12-hydroxydodecyloxy) benzamide, 4- (12-hydroxyoctadecyloxy) benzamide, 4- (11-hydroxyundecyl) Oxy) benzamide, 4- (10-hydroxydecyloxy) benzamide, 4-isostearyloxybenzamide, N- (2-hydroxyethyl) -4-[(2E, 6E) -3,7,11-trimethyl-2, 6,10-dodecatrienyloxy] benzamide, N, N-dimethyl-4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] benzamide, N, N -Di [(2E) -3,7-dimethyl-2,6-octadienyl] -4-aminobenzamide, 4- [N'-methoxycarbonyl-N-[(2E) -3,7-dimethyl-2,6 -Octadienylamino] benzamide, 4- [N-acetyl-N-[(2E) -3,7-dimethyl-2,6-octadi Nyl]] aminobenzamide, N- (2-hydroxyethyl) -4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] -2-hydroxybenzamide, N , N-diethyl-4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] -2-hydroxybenzamide, pea extract, tokamodoki extract, ikanoashi extract, hosoivo Nori Extract, Novonori Extract, Igis Extract, Keigi Extract, Harigi Extract, Hanegisu Extract, Usuba Watanagi Extract, Moray Togusa Extract, Fuyugusa Extract, Willow Willow Extract, Willow Tree Extract, Moyuyurena Extract, Vulgaris Extract, Mosayanagi Extracts, Sasabayanaginori extract, Wasabi extract, etc.

(18) Mucopolysaccharide (hyaluronic acid, chondroitin sulfate, etc.) degrading enzyme inhibitors Anacardic acid or its derivatives (6-pentadecatrienylsalicylic acid methyl ether, 6-pentadecatrienylsalicylic acid ethyl ether, 6-pentadecatrienyl) Salicylic acid propyl ether, 6-pentadecatrienyl salicylic acid butyl ether, 6-pentadecatrienyl salicyl alcohol methyl ether, 6-pentadecatrienyl salicyl alcohol ethyl ether, 6-pentadecatrienyl salicyl alcohol propyl ether, 6-pentadeca Trienyl salicyl alcohol butyl ether, 6-pentadecatrienyl salicylaldehyde methyl ether, 6-pentadecatrienyl salicylaldehyde ethyl ether, 6-pentadecatrienyl salicylaldehyde propyl Ether, 6-pentadecatrienyl salicylaldehyde butyl ether, 2-methyl ether-6-pentadecatrienyl cinnamic acid, 2-ethyl ether-6-pentadecatrienyl cinnamic acid, 2-propyl ether-6-penta Decatrienyl cinnamic acid, 2-butyl ether-6-pentadecatrienyl cinnamic acid, 2-methyl ether-6-pentadecatrienyl cinnamic alcohol, 2-ethyl ether-6-pentadecatrienyl cinnamic alcohol , 2-propyl ether-6-pentadecatrienyl cinnamon alcohol, 2-butyl ether-6-pentadecatrienyl] cinnamon alcohol, etc.), polyisoprenylated benzophenone derivatives (garcinol, isogarcinol, xanthothymol, Isoxanthothymol, gucciferon, etc.), Ikarisou extract, Yachima Taikiso (Indoka) ) Extract, Narco lily extract, scallop extract, yellow orchid extract, Oshida extract, Onji extract, Spruce extract, crow birch extract (half summer) extract, pheasant extract, wolfberry ) Extract, Goshuyu (Kurei) Extract, Senega Extract, Sendan Extract, Tamarind Extract, Tarragon Extract, Korean Radish (Dahi) Extract, Hachiku (Bamboo Bamboo) Extract, Daisies (Daisy) Extract, Milobaran Extract, Himekuma Willow Extract, Mockin Extract, Laurel extract, Yabusota extract, Anaaosa extract, Macrocystis integrofolia extract, Neocitus Ruetkeana extract, Nettle extract, Oats extract, Kata-bakusa extract, Yatabegusa extract, Shimatengusa extract, Ezotsunomatsue , Barbs horn Mata extract, Mrs. follower Uz data extract, Hanemoekisu, Miruekisu, Kuromiruekisu, Saki butyl mill extract, Nagamiruekisu, Hiramiruekisu, Matsumoekisu, Cladosiphon okamuranus extract, Nemacystus extract, bag glue extract, Kajimeekisu, bag funori extract, Mafunoriekisu like.

(19) Mucopolysaccharide synthesis promoter Stilbene derivative or salt thereof, morgin or salt thereof and derivatives thereof, N-acetylglucosamine, flax extract, cinnamon extract, mulberry extract, banana extract, bread extract, flounder extract, koto Gitznomata extract, Yaleus banori extract, Kagios banori extract, Susius banori extract, Amiaosa extract, Nagaaosa extract, Hosobanosasakamodoki extract, Hirohatosakamodoki extract, Yatsudegatatosakamodoki extract, Kurotosakamodoki extract, Nezushinosakamodoki extract, Yusora extract, Etsukinosakamodoki extract, Nankaisakamodoki extract, Himetosakamodoki extract, etc.

(20) intercellular adipogenesis promoter / intercellular lipid state improving agent phospholipids (phosphatidylethanol, phosphatidylcholine, phosphatidyltriethanolamine, phosphatidylserine, phosphatidic acid, phosphatidylglycerol, phosphatidylinositol, diacylphosphatidylcholine, diacylphosphatidylethanolamine, Diacylphosphatidylinositol, diacylphosphatidylserine, 1-cysteinylphosphatidic acid, 2-cysteinylphosphatidic acid, 1-glutathionylphosphatidic acid, 2-glutathionylphosphatidic acid, 1-azelaoylphosphatidic acid, 2-azela Oil phosphatidic acid, 1-hydroxyacyl phosphatidic acid, 2-hydroxyacyl phosphatidic acid, ceramide, glucosylceramide, Lactosylceramide, cerebroside, phosphatidylglucosylacylglycerol, N-oleoylsphingosine, N- (12-hydroxyoctadecanoyl) sphingosine, N- (16-hydroxyhexadecanoyl) sphingosine, N-salicyloylphytosphingosine, sphingo Myelin, soybean lecithin, egg yolk lecithin, etc.), sterins (cholesterol, dihydrocholesterol, cholesteryl stearate, cholesteryl hydroxystearate, macadamia nut oil fatty acid cholesteryl, β-sitosterol, stigmasterol, campesterol, ergosterol, 5-dihydroergo Sterol, phytosterol, 25-hydroxycholesterol, 26-hydroxycholesterol, 19-hydroxycholesterol, 22-ketocore Terol oxime, 6-ketocholesterol and 7-ketocholesterol or their derivatives), N-acetylneuraminic acid (sialic acid), N-glucosolneuraminic acid, gangliosides (galaose, ganglytriaose, gangliatetraose , Globotetraose, neolactotetraose, neolactohexaose, neolactooctaose, etc.), oligosulfated hyaluronic acid, hydroxytamoxifen compounds, glyceroglycolipids, pentoxyferrin, 3-deazaadenosine, carboxysamide Derivatives, Inositol polyamines, Sialic acid, Triterpenic acid derivatives, Lactose, Lactosamine derivatives, Sulfated chitin derivatives, Albumin, Panax ginseng extract, Tochiban ginseng extract, Oni lily extract, Sasa lily extract, Hakata lily Kiss, poppy extract, and the like.

(21) Keratolytic agent / stratum corneum exfoliation accelerator Tropolone and its derivatives, resorcin, lactic acid, urea, salicylic acid, guanidine, ethanolamine, kikarasuuri (Gurone) extract, fenugreek extract, wisteria bean extract, lentil extract, chickpea Extract, mungbean extract, etc.

(22) Plasminogen activator antagonist inhibitor Rabbit daisy extract, canamgra extract, caladium extract, raspberry extract and the like.

(23) Maillard reaction inhibitor aminoguanidine, flavanones (naringin, naringenin, naringin, naringenin, liquiritin, liquiritigenin, digallic acid, luteoic acid, ellagic acid, chlorogenic acid, glucogallin, tetralin, hamellitannin, gallic tannin, Tannic acid, geraniin, gallic acid, galloyl gallic acid, ellagitannin, hexagalloyl glucose, heptagalloyl glucose, tetragalloyl glucose, trigoloyl glucose, pentagalloyl glucose, digalloyl quinic acid, triguloyl quinic acid), 2- Hydroxyphenylalkylamine derivatives or salts thereof, phenylpropenoic acid derivatives (3- [2,3-bis (methoxymethoxy) phenyl] propenoic acid, 7- (4-hydroxy-3-methoxyphenyl) hepta-2,4,6 -Trienoic acid, 3- (3,5-dimethoxy-4-hydroxyphenyl) propenohydrazide, N'-isopropylidene-3- (2-methoxyphenyl) propenohydrazide, etc.), gypsum extract, sandalwood extract, etc. .

(24) Testosterone 5α reductase activity inhibitor γ-amino-β-hydroxybutyric acid esters (γ-amino-β-hydroxybutyric acid methyl ester, γ-amino-β-hydroxybutyric acid ethyl ester, γ-amino-β-hydroxybutyric acid) Propyl ester, γ-amino-β-hydroxybutyric acid butyl ester, γ-amino-β-hydroxybutyric acid ethylhexyl ester, γ-amino-β-hydroxybutyric acid hexadecyl ester, γ-amino-β-hydroxybutyric acid lauryl ester, γ- Amino-β-hydroxybutyric acid stearyl ester, γ-amino-β-hydroxybutyric acid oleyl ester, γ-amino-β-hydroxybutyric acid benzyl ester, γ-amino-β-hydroxybutyric acid phenyl ester, γ-amino-β-hydroxybutyric acid Ethyl glycol ester, γ-amino-β-hydroxybutyric acid sorbitol ester, γ-amino-β-hydride Loxybutyric acid polyoxyethylene glycol ester, γ-amino-β-hydroxybutyric acid glycerin ester, etc.), amine oxides (oleyldimethylamine oxide, stearyldimethylamine oxide, palmityldimethylamine oxide, myristyldimethylamine oxide, lauryldimethylamine oxide) Dimethyl lauryl ethoxyamine oxide, dihydroxyethyl lauryl amine oxide, coconut oil alkyl dimethyl amine oxide, etc.), alkyl betaines (coconut oil fatty acid amide propyl betaine, coconut oil alkyl betaine, lauryl dimethylaminoacetic acid betaine, lauric acid amide propyl betaine, Laurylhydroxysulfobetaine, 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine), Midine N-oxide derivatives (2-amino-4-methyl-6-piperidinopyrimidine-3-oxide, 2-amino-4-methyl-6- (1-pyrrolidinyl) pyrimidine-3-oxide, 2-amino- 4-methyl-6-morpholinopyrimidine-3-oxide, 2-amino-4-methyl-6- [1- (4-methylpiperazinyl)] pyrimidine-3-oxide, 2-amino-4- (1 -Hexahydroazepinyl) -6-methylpyrimidine-1-oxide, 2-amino-4-dimethylamino-6-methylpyrimidine-1-oxide, 2-amino-4-allylamino-6-methylpyrimidine-1- Oxide, 2-amino-4-benzylamino-6-methylpyrimidine-1-oxide, 2-amino-4,5-methyl-6-piperidinopyrimidine-3-oxide, 2-amino-4-ethyl-6 -Morpholinopyrimidine-3-oxide, 2-amino-4-methyl-5-nitro-6-piperidinopyrimidine-3-oxide, 2,5-diamino-4-methyl-6-piperidinopi Limidine-3-oxide, 2-amino-4-methyl-5,6-bis (1-pyrosinyl) pyrimidine-3-oxide, 2-amino-4-methyl-5-piperidino-6- (1-pyrrolidinyl) pyrimidine -3-oxide, 2-methyl-4-amino-6-piperidinopyrimidine-3-oxide, 2-methyl-4-amino-5-bromo-6- (1-pyrosinyl) pyrimidine-3-oxide, 2 -Methyl-4-amino-5-nitro-6-piperidinopyrimidine-3-oxide, 2-methyl-4,5-diamino-6-piperidinopyrimidine-3-oxide, 2-methyl-4-amino -5,6-bis (1-pyrrolidinyl) pyrimidine-3-oxide, 2-amino-4-methyl-6-piperidinopyrimidine-3-oxide monohydrochloride, 2-acetylamino-4-methyl-6- Piperidinopyrimidine-3-oxide, 2,4-diamino-6-phenoxypyrimidine-3-oxide, 2,4-diamino-6- (2,4-dichlorophenoxy) pyrimidine-3-oxide, 2,4- Diamino-6- (2 , 4,6-Trichlorophenoxy) pyrimidine-3-oxide, 2,4-diamino-5-nitroso-6- (2,4-dichlorophenoxy) pyrimidine-3-oxide, 2,4-diamino-5-nitro- 6- (2,4,6-trichlorophenoxy) pyrimidine-3-oxide, 2,4-diamino-5-nitro-6- (2,4-dichlorophenoxy) pyrimidine-3-oxide, 2,4,5- Triamino-6- (2,4-dichlorophenoxy) pyrimidine-3-oxide, 2,4-diamino-5-bromo-6- (2,4-dichlorophenoxy) pyrimidine-3-oxide, etc.), p-menthane- 3,8-diol, monoglyceryl-D-glucoside monotridecanoate, 1-oN-pentadecylglycero-D-glucoside, monopentadecanoic acid glyceride sulfate, etc. glyceride sulfate, monopentadecyl Glyceryl ether sulfate, 1-o-hexadecyl-2-o-methylglycerol, 1-o-octadecyl -2-o-methylglycerol, 1-o-oleyl-2-o-methylglycerol, acetylcarnitine or its salt, geranylgeranylacetone, hydroxamic acid derivative or its salt, gingerone glycoside, benzeneoxyacetic acid derivative ([5- [2- [1-phenyl-1- (3-pyridyl) methylideneaminooxy] ethyl] -7,8-dihydronaphthalen-1-yloxy] acetic acid, etc.), isorhamnetin-3-robinobioside, xanthone derivatives , Proanthocyanidins (grape seed extract proanthocyanidins, apple-derived proanthocyanidins, pine-derived proanthocyanidins, purified procyanidin oligomers, procyanidin B-1, procyanidin B-2, procyanidin B-3, procyanidin C-1 etc.), aracaci extract , Angelica extract, Anse extract, Honzu extract, Ichiyakuso Cormorant (one medicinal herb) extract, licorice extract, psyllium (carlet child, carve herb) extract, psyllium shabushi extract, olive extract, giant dogfowl extract, seisei extract, calla cucumber extract, cinnamon crocodile extract Extract, Catalpa extract, Kukui nut extract, Camphor tree extract, Kubaba extract, Black-bellied red extract, Snapper extract, Snapdragon extract, Snapdragon extract, Kippi extract, Japanese beetle extract, Cilantro extract, Kobushi extract, Mokuren extract, Sanekazu extract , Colombo extract, Conslango extract, Sasanka extract, Sweet potato extract, Sanebuto jujube extract, Sandscon extract, Potato extract, Shishigashira extract, Nashishi extract, coriander extract, stevia extract, Takatodai extract (Otsuka) extract, Tarayo (Oba winter blue, Ichiha tea, bitter tea, bitter tea) extract, taranoki extract, nigaki (Nakiki) extract, Nurde (penta) extract, hakama Urabosi (bone crush) extract, spider magnolia extract, scented squirrel extract, stag beetle extract, sorghum grass extract, cicada carrot (participant) extract, mangosteen extract, ginger extract, melaleuca extract, yachabushi extract, himeya shabushi Extract, Oobaya Shabushi Extract, Yakumosou Extract, Yamahanoki (Yamatake) Extract, Longan (Yongan) Extract, Locon (Yoshi, Sone) Extract, Logwood Extract, Lantana Extract, Phthradinones, Benzoxazinones, Phosphonic Acid Derivatives , Cyproterone, 5α-androstene- 3α, 17β-diol, medroxyprogesterone, norethisterone, mestanolone, ichihatsu (primary) extract, katsu extract, kanto extract, sanjiko extract, shiramo extract, prunus extract, scabbard licorice extract, fritillary extract, cypress extract, seaweed extract, Yoremoku extract.

(25) Odor-eliminating agent: Inond extract, Elemi extract, Danmar extract, vanilla bins extract, pine extract and the like.

  The ingredients derived from plant-based materials used as additives include Aokazura (Seifu Fuji) extract, Aotenma extract, Akasuguri extract, Akinire (crust) extract, Aguay guassu extract, Abiyu extract, Abiurana extract, Yellow support extract , Ylang ylang extract, phalaenopsis extract, uba tea extract, suzuran extract, unboku extract, elderberry extract, sasayukiyuki extract, sasanoyuki extract, tossed cactus extract, ohia catechu extract, onoelan extract, crab extract , Karaya extract, Garyu extract, Kawaratake extract, Candelilla extract, Canna extract, Kidachi pepper extract, Kimenka extract, cabbage extract, Kiraja saponaria extract, Ginseng extract, Kimbusen extract, Guape・ Vermela extract, Kugenumaran extract, Coosberry extract, Kutiti River extract, Curkurigo-Latifolia extract, Kuroganemochi (rescue) extract, Kourian extract, Sapotea mariyo extract, Salmon berry extract, Salamander ) Extract, Cactus Cactus Extract, Cinnamon Extract, Shunlan Extract, Shozuk Extract, Shirobanatsuta Extract, Cinchona Sacylbra Extract, Swimberry Extract, Star Apple Extract, Sulgaran (Oran) Extract, Scots Pine Extract, Scots Tree Extract, Seiyo Japanese butterfly extract, mistletoe extract, sennin cactus extract, senboku extract, elephant weevil extract, cinnamon extract, some mono-potato extract, dark sweet cherry extract , Prickly pear extract, Choco nostay extract, Korean mugwort extract, Azalea extract, Azalea extract, Azalea extract, Duberry extract, Papaver extract, Tragacanth extract, Triacanthus extract, Neiseria berry Extract, rapeseed extract, physalis extract, paw doce extract, hakukayumatou extract, hakuberry berry, batata extract, oysters extract, balata extract, hulcan orchid extract, pecan nut extract, chickweed extract, himomeooran extract, Brazilian carrot extract, Branjen extract, Fruceria extract, Blond psyllium extract, Hetsukaran extract, Heneken extract, Berry extract, Persea extract, Pervianburg extract, Pereschia gran Ifolia extract, Boysenberry extract, Hosairan extract, Pouteria sapota extract, Pouteria rukuma extract, Hosobabarengiku extract, Whataberry berry extract, Masalan basoba extract, Masala nuba de cereal extract, Masheira de Boi extract, Matta・ Auryo extract, Mulberry extract, Green potato extract, Purple corn extract, Megacansa opuntica extract, Mokukirin extract, Japanese maple extract, Morero cherry extract, Yakawa purple extract, Cornflower extract, Ruritama thistle Indigo sashimi) extract, red currant extract, red pitaya extract, lemongrass extract, wax palm extract, logan berry extract and other plant extracts.

Ingredients derived from plant-based materials used as additives include Dunaliella genus Dunaliella extract, Chlorococcus chlorococcus extract, Kuwanomimo genus mulberry extract, Volbox genus genus extract, Volbox genus Volbox extract, Palmera extract, Yotsumemo extract, Aomido genus Zoriori extract , Tsurugidomiro extract, Hibidomylo spp. Black Ivy extract, Casanori spp. Green algae extract such as Japanese pepper extract, Sumiremo violet extract, Hosimidro extract, Fuchinashimidoru extract, Cyanobacteria genus Suizendinori extract, Blue-green algae extract such as Blue-green extract, Yulemo extract, Piraera genus Piraela extract, Shiomidomo genus Nagamisiomidro extract, Isovine genus Iso Grape extract, Isogawara genus Isogawara extract, Black moth genus Black moth moth extract, Casilla genus Kashirazaki extract, Muchimo genus Muchimo extract, Muchimo genus Hiramchimo extract, Muchimo genus Quercus crisposa extract, Amygusa genus Sakibiro amiji extract, Common genus Common genus extract, Jigamigusa genus Jigmygusa extract, Nami-makura genus Hirami-makura extract, Someraceae genus Someraceae extract, Navaimo genus Navarimo extract, Chasomen genus Motsuki-chisoume Extract , Crested genus Extract, Crested genus, Common crested genus Common extract, Common crested genus Ezobukuro extract, Crested genus Crested genus Extract, Caryaceae Crested genus Extract, Blossomus genus Extract, Shark Crested shark Yokojimanori extract, genus Cyprus genus extract, genus genus genus extract, vine genus turmeric extract, genus chromae Brown algae extracts such as kiss, chrysanthemum genus chrysanthemum extract, nerecomb genus extract, brown spruce burdock extract, cabbage genus extract, etc. Amanori Tasa Extract, Amanori Phyritasa Extract, Amanori Benitasa Extract, Rhodocorton Milnobeni Extract, Kona Hada Hyakona Hada Extract, Kona Hada Yokore Kona Hada Extract, Kona Hada Ao Kona Hada Ex Extracts Kisses, Tengusa spp. Extract Coral coral extract, Centacum spruce cadaver extract, Centacum spp.Humram cadaver extract, Centacum spp. Centipede extract, Centipede spruce extract, Centipede spruce extract, Centipede spp. Kintoki genus Pinus extract, Kintoki fushikintoki extract, Kintoki tsunomukade extract, Kintoki nagakintoki extract, Kintoki spruce cadaver extract, Kakiteto Obakintoki extract, Nagaobane spp. Tuscanula genus Karimenia extract, Tsukasanori Otsukasanori extract, Tsukasanori Hanagakarimenia extract, Honooka genus Hono Extracts Isodantsu extract, Atsubanori genus Azobanori extract, Ogonori spp. Ogonori Katagonori Extract, Ogonori Ryukyu Ogonori Extract, Ogonori Ogonori Extract, Ogonori Ittsuginu Extract, Ogonori Yumigataonogori Extract, Ogonori genus Chibiriogonori extract, Ogonori genus Mosaogonori extract, Ogonori genus Fusarium extract, Fushikenori genus Fukukurenori extract, Namiiwatake namiiwatake extract, Saimi genus Thymus extract, Sami genus extract, Lotus Black-headed ginseng extract, Cyprinus genus Hachibukuro extract, Madaragusa genus extract, Madaragusa Etsukimadara extract, Taoyagi Taoagisou extract, Taoyagi genus Hanakusa extract, Fukutsunagi genus Fukutsunagi Hananoeda extract, Hiraota goat genus Hirata goat extract, Darus genus Masagoshi Bali extract, Darus genus Anadalus extract, Weavusa genus Weibusa extract, Bee Fuchunori spp. Extract, Suzushironori Extract, Usbeni Genus Usbeni Extract, Hasujiginu Hasujiginu Extract, Nagakonono Hanori Nagakonohanori Extract, Sugiginus Sugiginu Extract, Sugiginus Atsubasuginu Extract, Hius Banori Genius Cageus Banori Extract, Haius Banori Genius Heusius Bavaria Usubanori Extract, Hausubanori Genus Huisubanori Extract, Usubanorimodoki Genus Usubanorimodoki Extract, Ayanishiki Ayanishiki Extract, Ayaginu Ginnu Extract, Dadia Enasidadia Extract, Shimadadia Isohagi Extract, Shimadadia Shimadadia Extract, Dajimodoki Daijimodoki Extract, Makuri Genome Extract, Hanegusa Hanegusa Extract, Hanegusa Kehanegusa Extract, Kozanemo Cozaemone Extract Chrysanthemum extract, Himego-genus Himego-keki extract, Himego-keki-Kuro-himegome extract, Hyodosigki chrysanthemum extract, Hyodosigus hyodosigusa extract, Hyodosigus genus Usobahiodosi extract, Isomegusa isomegusa extract, Suzynagusa spp. Red algae extracts such as genus Isobasho extract, Ideukogome genus Yukogome extract, Ochimomoku Okichimozuku extract, Chisujinori genus Chisujinori extract, Axillary extract such as Dicumulus extract, White-backed duck extract, Hositsurimo extract, Likuntamnus extract, Flask extract, Chaboflask extract, Tripera extract, Yellow alga extract such as Hikarimo Hikarimo extract, etc.

  Examples of ingredients derived from animal materials used as active ingredients or additives include chicken crown extract, cow, pig or human placenta extract, pig or cow stomach, duodenum, intestine, spleen extract or decomposition products thereof, cow or pig Brain tissue extract, water-soluble collagen, collagen derivatives such as acylated collagen, collagen hydrolyzate, elastin, elastin hydrolyzate, water-soluble elastin derivative, keratin and its degradation product or derivatives thereof, silk protein and its degradation product Or derivatives thereof, porcine or bovine blood cell protein degradation product (globin peptide), cattle or porcine hemoglobin degradation product (hemin, hematin, heme, protoheme, heme iron, etc.), milk, casein and degradation products thereof or derivatives thereof Skim milk powder and its degradation products or derivatives thereof, lactoferrin or its degradation products, egg component, fish degradation , Nucleic acid-related substance (ribonucleic acid, deoxyribonucleic acid), and the like.

  Examples of components derived from microbial materials used as active ingredients or additives include yeast metabolites, yeast extract, bacterial metabolites, bacterial extracts, metabolites such as mold or mushroom, actinomycetes metabolites, mold or mushroom Extract, Actinomyces extract, Natto metabolite, Natto extract, Rice fermented extract, Rice bran (red rice bran, white birch) fermented extract, Euglena extract or its degradation products or their water-soluble derivatives, lactic acid fermentation of raw milk or skim milk powder Products, trehalose or derivatives thereof.

  In addition, as a plant, animal, or microbial material, any site, cell, tissue, organ, metabolite, etc. derived from a transgenic body or a cell fusion can be used. Furthermore, it is obtained by culturing cells of any site, cell, tissue, organ, etc., for example, cultured cells derived from each tissue (cultures derived from animals such as fibroblasts, Langerhans cells, macrophages, epidermal cells, hepatocytes, etc.) Cell etc.), undifferentiated cell group, cell group in the middle of differentiation, and their metabolites can also be used.

  As natural ingredients used as active ingredients or additives, seawater such as deep sea water, for example, sea salt, seawater dried product, inorganic salt obtained from the Dead Sea or Atlantic Ocean or Pacific Ocean (sodium chloride, magnesium chloride, chloride) Potassium etc.), sea mud or mud (Fango), for example, Italian mud, German fungo, Eifel Fango, Freiburg fungo, etc. Sea mud or mud (containing components: silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, Manganese oxide, sodium oxide, potassium oxide, magnesium oxide, calcium oxide, strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic, water), marine such as saintoku stone Ingredients etc.

  Extracts derived from plant-based raw materials, animal-based raw materials, microbial-based raw materials, and other natural product raw materials used as active ingredients or additives are processed in a conventional manner according to the product type and form to be added (for example, pulverized) , Milling, washing, extraction, degradation, fermentation or metabolic conversion by microorganisms, fractionation, purification, pressing, filtration, drying, powdering, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc. It is only necessary to select and use any of various materials.

  The solvent used for extraction may be selected in consideration of the intended purpose and type of the product to be provided or the processing to be performed later. Usually, water, methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol, isopropanol are used. Lower alcohol such as butanol or hydrous lower alcohol, propylene glycol, 1,3-butylene glycol, 1,2-butylene glycol, 1,4-butylene glycol, 1,5-pentanediol, 1,2-pentanediol, 1, Polyhydric alcohols such as 3-pentanediol, 1,4-pentanediol, 1,3,5-pentanetriol, glycerin, polyethylene glycol (molecular weight 100 to 100,000) or water-containing polyhydric alcohols, acetone, ethyl acetate, diethyl ether , Dimethyl ether, ethyl methyl ether, dioxane, acetonitrile, Various organic solvents such as silene, benzene, chloroform, carbon tetrachloride, phenol, toluene, etc., acids (hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, formic acid, acetic acid, etc.) and alkalis (sodium hydroxide, water, etc.) prepared as appropriate. It is desirable to use one or a mixture of two or more selected from potassium oxide, calcium hydroxide, ammonia and the like. However, when it is not preferable to contain a solvent depending on the application, it is sufficient to use only water or ethanol that can be easily removed after extraction, and it can be used alone or in any mixture with water. What was extracted may be sufficient.

  Regarding the extraction method, the temperature of the solvent, the weight ratio of the solvent to the raw material, or the extraction time can be arbitrarily set for various raw materials and the solvent used. Although it can set arbitrarily as the temperature of a solvent in the range of -4 degreeC to 100 degreeC, 10-40 degreeC vicinity is preferable from the point of stability of the component contained in a raw material. Also, the weight ratio of the solvent to the raw material can be arbitrarily set, for example, within the range of the raw material: solvent 4: 1 to 1: 200, and the weight ratio of 1: 1 to 1:10 is particularly preferable.

  Decomposition mainly includes acid decomposition, alkali decomposition, enzyme decomposition, and high-temperature and high-pressure decomposition. In the decomposition with an acid, for example, it is preferable to use an inorganic acid or an organic acid such as hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, acetic acid, formic acid, oxalic acid, hydrogen bromide, perchloric acid, and periodic acid. In the decomposition by alkali, for example, sodium hydroxide, potassium hydroxide, calcium hydroxide, ammonium hydroxide, barium hydroxide, sodium carbonate, ammonium carbonate, calcium carbonate, magnesium hydroxide, sodium silicate, etc. are preferably used. In the decomposition with acid or alkali, the concentration, reaction time, reaction temperature, and the like can be arbitrarily set for the target raw material. In the enzymatic degradation, it is preferable to use an enzyme having a function of degrading proteins, polysaccharides, lipids or complexes thereof having an important function particularly with respect to cell structure, tissue structure, etc., for example, aminopeptidase, dipeptidase, dipeptide Peptidyl peptidase, tripeptidyl peptidase, carboxypeptidase, serine protease, trypsin, chymotrypsin, cysteine protease, thiol protease, papain, aspartate endopeptidase, metalloendopeptidase, promeline, thermolysin, pronase, pepsin, rennin, Proteolytic enzymes (proteases) such as pancreatin, chymopapain, ficin, collagenase, elastase, amylase, takaamylase, cellulase, hemicellular Polysaccharide-degrading enzymes such as zectin, pectinase, polygalacturonase, dextranase, and pralanase, chicken egg white lysozyme, human lysozyme, papaya lysozyme, cabra lysozyme, barley lysozyme, zymolyce, lysozyme chloride, glucanase, gluco Examples include cell wall lytic enzymes such as uronidase, chitinase, and kilosanase. In the case of using an enzyme, the concentration, reaction time, reaction temperature, pH of the solution, and the like can be arbitrarily set, but it is particularly preferable to set the optimum value for the enzyme used.

Fermentation or metabolic conversion by microorganisms can be carried out by inoculating and growing at least one or more microorganisms on a raw material used as a substrate. Inoculation of microorganisms to the substrate can be done by adding microorganisms directly into the substrate, or by adsorbing them on a carrier such as alginic acid, polyvinyl, gelatin, etc., for example, in the form of fine beads composed of microorganisms and carrier. Further, it can be used by being fixed to the tube wall of the bioreactor. Fermentation or metabolic conversion by microorganisms is not particularly defined as a microorganism to be used, but can generally be defined as microorganisms other than pathogenic microorganisms that exhibit significant toxicity to living bodies. Examples of microorganisms to be used include, but are not limited to, yeasts classified into the genus Aciculoconidium, Actonia, Aessosporon, Ambrosiozyma, Amphierna, Anthomyces, Apiotrichum, Arthroascus, Arxula, Ascotrichosporon, Ashbia, Ashbya Genus, Asporomyces, Atelosaccharomyces, Azymocandida, Azymohansenula, Azymomyces, Azymoprocandida, Babjevia, Ballistosporomyces, Basidiotrichosporon, Bensingtonia, Blastobotrysbota, Blastodlastrzo Brettanomyces (Brettanomyces bruxellensis, Brettanomyces anomalus, etc.), Bullera, Bulleromyces, Candida (Candida albicans, Candida amylolenta, Candida anomala, Candida boidinii, Candida entomaea, Candida etchellsment, Candida etchellsii, Candida etchellsment Candida intermedia, Candida krusei, Candida lactosa, Candida lipolytica, Candida mogii, Candida parapsilosis, Candida sake, Candida tropicalis, Candida versatilis, Candida vulgaris, etc., Castellania, Chlamydozyma, Chromotorula, Citeromyces, Cladosporium, Clavispora, Crebrothecium, delbaryo, genus halotolerans, Debaryomyces hansenii, etc.), Debaryozyma, Dekkera, Dekkeromyces, Dematium, Dipodascus, Eeniella, Enantiothamnus, Endoblastoderma, Endoblastomyces, Endomyces, Endomycopsis, Endyllium, Etelexium, Entelex Genus, Eutorula, Eutorulopsis, Fabospora, Fellomyces, Fermentotrichon, Filobasidium, Galactomyces, Geotrichoides, Geotrichum, Guilliermondella, Hanseniaspora, Hansenulaan, Hansenulaan, Hansenulaan, Hansenula Hansenula wickerhamii), Hypomyces, Issatchenkia, Kloeckera (Kloeckera brevis, Klo) eckera fluorescens, Kloeckera japonica, etc.), Kloeckeraspora, Kluyveromyces (Kluyveromyces bulgaricus, Kluyveromyces marxianus, Kluyveromyces thermotolerans, Genus Kockovaella, Kurtzmanomyces, Leucosporidium, Leucosporidium, Leucosporidium Monospora, Monosporella, Mrakia, Myceloblastanon, Mycocandida, Mycoderma, Mycotorula, Mycokluyveria, Mycotoruloides, Myxozyma, Nadsonia, Nectaromyces, Nematospora, Otosporomyces, Ogataea, Ogataea , Oosporidium genus, Pachysolen genus, Parasaccharomyces genus, Paratorulopsis genus, Parendomyces genus, Petasosospora genus, Pichia genus (genus Pichia amylophila, Pichia farinosa, Pichia guilliermondii, Pichia membranifaciens, Pichia mogirum, genus Proticcpo Proteomyces, Pseudohansenula, Pseudomonilia, Pseudomycoderma, Pseudosaccharomyces , Pseudozyma spp, Rhodomyces genus, Rhodosporidium genus, Rhodotorula genus, Saccharomyces genus (Saccharomyces aceti, Saccharomyces cerasi, Saccharomyces cerevisiae, Saccharomyces exiguus, Saccharomyces unisporus, Saccharomyces fibuligera etc.), Saccharomycodes genus, Saccharomycopsis spp, Saturnispora genus, Schizoblastosporion spp, Schizosaccharomyces spp , Schwanniomyces genus, Selenotila genus, Selenozyma genus, Smithiozyma genus, Sporidiobolus sp Genus, Vanrija, Waltomyces, Willia, Willopsis, Wingea, Xanthophyllomyces, Yamadazyma, Zendera, Zygofabospora, Zygopichia, Zygohansenula, Zygorenospora, Zygosaccharomyces, Zygosaccharomyces, etc. . Microorganisms classified as bacteria include Acetobacter genus (Acetobacter aceti, etc.), Achromobacter genus, Acidianus genus, Acidobacterium genus, Acidithiobacillus genus, Acrocarpospora genus, Actinoalloteichus genus, Actinocorallia genus, Actinokineospora genus, Actinomadspura genus, Actinomadspura Actinosynnema genus, Aerococcus genus, Aeromicrobium genus, Agrobacterium genus, Agromyces genus, Ahrensia genus, Alcaligenes genus, Alicyclobacillus genus, Alloiococcus spp. , Aureobacterium genus, Azotobacter genus, Bacillus genus (Bacillus brevis, Bacillus subtilis etc.), Bacteroides genus, Beneckea genus, Bifidobacterium genus (Bifidobacterium bifidum, Bifidobacterium longum, Bifidobacterium breve, Bifidobacterium infantis etc.), Brachybacterium genus, Brevicillus, Brevundimonas, Burkholderia, Carnobacterium, Catellat genus ospora, Cellulomonas, Chainia, Chromobacterium, Chryseobacterium, Citrobacter, Clavibacter, Corynebacterium, Couchioplanes, Cryptosporangium, Curtobacterium, Dactylosporangium, Deinococcus, Delftia, Dermatia, Dermatia , Elytrosporangium, Enterobacter, Erwinia, Escherichia, Eubacterium, Excellospora, Exiguobacterium, Faenia, Flammeovirga, Flavobacterium, Flexibacter, Geodermatophilus, Globicatella, Gluconacetobaceto, Gluconacetobacter Genus, Gordonia, Halobacterium, Halococcus, Herbidospora, Hydrogenophilus, Hyphomicrobium, Hyphomonas, Intrasporangium, Janibacter, Jonesia, Kibdelosporangium, Kineopocusato, Kitasposatos, Kitasposatos, Kitasposatos Klebsiella, Kocuria, Kurthia, Lactobacillus (Lactobacillus rimae, Lactobacillus dive rgens, Lactobacillus carnis, Lactobacillus piscicola, Lactobacillus acidophilus, Lactobacillus amylophilus, Lactobacillus animalis, Lactobacillus brevis, Lactobacillus casei, Lactobacillus curvatus, Lactobacillus bulgaricus, Lactobacillus delbrueckii, Lactobacillus fermentum, Lactobacillus fructivorans, Lactobacillus fructosus, Lactobacillus helveticus, Lactobacillus hilgardii, Lactobacillus homohiochii, Lactobacillus kefiri, Lactobacillus malefermentans, Lactobacillus murinus, Lactobacillus paracasei, Lactobacillus paracasei subsp. tolerans, Lactobacillus parakefiri, Lactobacillus pentosus, Lactobacillus plantarum, Lactobacillus reuteri, Lactobacillus rhamnosus, Lactobacillus sakei, Lactobacillus confusus, Lactobacillus viridescens, Lactobacillus johnsonii, Lactobacillus viscosus, Lactobacillus bunchneri , Lactobacillus fermentatae, Lactobacillus acidophil-aerogenes, Lactobacillus leichmannii, Lactobacillus gasseri, Lactobacillus bifidus, Lactobaci llus jugurt, Lactobacillus caucasicus, Lactobacillus arabinosus, Lactobacillus kunkeei, Lactobacillus nagelii, Lactobacillus fornicalis, Lactobacillus pentoaceticus, Lactobacillus xylosus, Lactobacillus minutus, etc.), Leuconostoc genus (Leuconostoc lactis, Leuconostoc dextranicum, Leuconostoc mesenteroides, Leuconostoc oenos, Leuconostoc paramesenteroides, Leuconostoc cremoris, Leuconostoc citrovorum etc.), Listonella genus, Lucibacterium genus, Luteococcus genus, Magnetospirillum genus, Marinilabilia genus, Marinospirillum spp. Genus, Nocardioides, Nonmuraea, Nonomuria, Oceanospirillum, Ochrobactrum, Oerskovia, Oligella, Paenibacillus, Pediococcus ui, etc.), Pedobacter, Peptococcus, Peptostreptococcus, Pilimelia, Pimelobacter, Planobispora, Planococcus, Planomonospora, Prevotella, Propionibacterium, Proteus, Protomonas, Pseudomonas, Genus, Rathayibacter, Rhizobium, Rhizomonas, Rhodobacter, Rhodococcus, Rhodopseudomonas, Rhodospirillum, Rothia, Rubrobacter, Ruegeria, Saccharomonospora, Siracrothinas, Sporolactobacillus spp., Stenotrophomonas spp., Streptoalloteichus spp., Streptococcus spp. (Streptococcus durans, Streptococcus faecalis, Streptococcus faecium, Streptococcus bovis, Streptococcus equinus, Streptococcus mutans, Streptococcus salivarius, Streptococcus thermophilus, Streptococcus agalactiae, Streptococcus mitis, Streptococcus pyogenes, Streptococcus pneumoniae, Streptococcus lactis , Streptococcus dysgalactiae, Streptococcus sanguis, Streptococcus acidominimus, Streptococcus avium, Streptococcus uberis, Streptococcus cremoris, Streptococcus diacetilactis, etc. Genus, Thiobacillus genus, Thiomonas genus, Thiosphaera genus, Weissella genus, Xanthobacter genus, Xanthomonas genus, Zymomonas genus and the like. Microorganisms classified as non-yeast ascomycetes, basidiomycetes or incomplete fungi include Allomyces, Amoebidium, Amorphotheca, Arthroderma, Ascoidea, Ascobolus, Ascodesmis, Aspergillus, Aureobasidium, Botryosphaeria , Botryotinia, Brachybasidium, Byssochlamys, Capnodium, Ceratocystis, Ceratomyces, Chaetomium, Chrysella, Chrysocelia, Chytridium, Claviceps, Cochliobolus, Coemansia, Genus Genus, Cyttaria, Dasyspora, Derchslera, Derchmyces, Dichomyces, Dothidea, Endogone, Entomophthora, Emericella, Eupenicillium, Eurotium, Exobasidium, Gibberella, Glomus, Graphiola, Graphnoola, Harpella Helicomyces, Hellvella, Hemicarpenteles, Hyphochytrium, Hypocrea, Laboulbenia, Labyrinthula, Leptosphaeria, Leptosphaerulina, Lophodermium, Melanotaenium , Microascus, Microstroma, Medeolaria, Melampsora, Melampsporella, Morchella, Monascus, Monilinia, Monoblephalis, Mycospharella, Nannizzia, Nectria, Neolecta, Neurospora, Nodulosphaeria, Olizadium, Genus, Penicillium, Perenospora, Pestalotiopsis, Phomopsis, Phragmi
diella genus, Pneumocystis genus, Preussia genus, Pleospora genus, Puccinia genus, Pythium genus, Ravenelia genus, Rickia genus, Rhinocladiella genus, Rhizidiomyces genus, Rhizoctonia spp. Sordaria genus, Sporidiobolus genus, Stibella genus, Stigmatomyces genus, Sydowiella genus, Talaromayces genus, Taphrina genus, Thraustochytrium genus, Tolyposporium genus, Trichoglossum genus, Trichoma genus, Ustilago genus, Verticillium genus, Xylaria genus and the like.

  In fermentation or metabolic conversion by microorganisms, in addition to various raw materials such as plant-based materials, animal-based materials, and other natural product-based materials, the growth and metabolism of microorganisms are regulated or activated, and special biosynthesis or degradation pathways are induced. In order to achieve this, various compounds can be added to the raw material. For example, as a carbon source, a sugar or ethane such as glucose, fructose, galactose, sucrose, maltose, mannose, lactose, glycerol, starch, etc. , Hydrocarbons such as methane, propane, butane, formic acid, acetic acid, propionic acid, lauric acid, palmitic acid, fatty acids such as oleic acid, linoleic acid, linolenic acid, etc., nitrogen sources such as ammonium sulfate, ammonium hydrochloride, ammonium phosphate, etc. Ammonium salt, urea, uric acid, amino acids, etc. Vitamins and compounds that contain potassium, calcium, magnesium, sodium, sulfur, phosphorus, chlorine, etc., as well as iron, copper, zinc, cobalt, nickel, boron, manganese, molybdenum, tin, selenium, silicon It is possible to further add compounds contained in the composition such as arsenic, vanadium, chromium and fluorine. In addition, the optimum temperature, oxygen supply amount, pH, pressure, etc. that affect the growth and metabolic activity of various microorganisms can be arbitrarily set according to the characteristics inherent to various microorganisms. Can be arbitrarily set in the range of 10 to 50 ° C., and the pH can be arbitrarily set in the range of 1 to 14.

  In fractionation or purification, generally known techniques can be used as appropriate. In addition to solvent extraction, for example, liquid chromatography (ion exchange chromatography, ion exclusion chromatography, affinity chromatography, gel filtration chromatography, size exclusion chromatography, etc.). Chromatography, hydrophilic adsorption chromatography, hydrophobic adsorption chromatography, ligand exchange chromatography, etc.), dialysis with semipermeable membrane, crystallization and recrystallization of components, filter paper, membrane filter, ultra filter, Examples thereof include filtration using activated carbon, a filter aid, and the like, centrifugal separation, and fractional precipitation, which is an application thereof, and density gradient separation methods such as a red zone centrifugal separation method and a density gradient sedimentation equilibrium method.

  In the present invention, other compounds used as additives include silicic anhydride, magnesium silicate, talc, kaolin, bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide, titanium oxide, calcium carbonate, Inorganic pigments such as magnesium carbonate, yellow iron oxide, bengara, black iron oxide, gunjou, chromium oxide, chromium hydroxide, carbon black, calamine, hydrogen peroxide, sodium persulfate, ammonium persulfate, sodium perborate, peroxy Urea oxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, sodium pyrophosphate, sodium orthophosphate, sodium silicate hydrogen peroxide adduct, sodium sulfate hydrogen peroxide adduct, Sodium chloride Hydrogen oxide adduct, β-tyrosinase enzyme solution, mushroom extract, strontium sulfate, sodium sulfide, barium sulfide, calcium sulfide and other inorganic reducing agents, thioglycolic acid or its salts (calcium thioglycolate, sodium thioglycolate, Redox agents such as lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate), 5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4 -Methylaminoanthraquinone, 3,3'-iminodiphenol, 2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, salt Metaphenylenediamine, orthoaminophenol, acetic acid N-phenylparaphenylenediamine, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4 -Diamine, nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol, picramic acid, sodium picrate, N, N'-bis (4-aminophenyl) -2,5- Diamino-1,4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenylparaphenylenediamine, metaaminophenol, metaphenylenediamine, 5-aminoorthocresol sulfate, 2-amino-sulfate 5-nitrophenol, ortho-aminophenol sulfate, ortho sulfate Lorparaphenylenediamine, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene-2,5-diamine sulfate, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, parasulfate sulfate Nitrometaphenylenediamine, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate, catechol, diphenylamine, α-naphthol, hydroquinone, phloroglucin, 2-hydroxy-5-nitro-2 ', 4 ′ -Diaminoazobenzene-5′-sulphonate, dyes such as hematein, natural animal flavors such as musk, civet, castrium, ambergris, anise essential oil, angelica essential oil, ylang ylang essential oil, iris essential oil, cormorant Kyou essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, guayakwood essential oil, cumin essential oil, black letter essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil , Jasmine essential oil, gingergrass essential oil, cedar essential oil, spearmint essential oil, Western peppermint essential oil, Otsuka perfume essential oil, tuberose essential oil, dichroic essential oil, orange flower essential oil, winter green essential oil, troubalsum essential oil, rose essential oil, rose essential oil, palmarosa essential oil, salmon Essential oil, Hiba essential oil, sandalwood essential oil, petit gren essential oil, bay essential oil, vetiva essential oil, bergamot essential oil, peru balsam essential oil, boadrose essential oil, mellow essential oil, mandarin essential oil, eucalyptus essential oil, lime essential oil, lavender essential oil, linaloe essential oil, lemongrass Oil, lemon essential oil, rosemary essential oil, vegetable flavors such as Japanese mint essential oil, other synthetic flavors, 5-amino-o-cresol, o-aminophenol, m-aminophenol, p-aminophenol, 2 , 6-Diaminopyridine, 5- (2-hydroxylethylamino) -2-methylphenol, N, N-bis (β-hydroxyl) -p-phenylenediamine sulfate, N, N-bis (2-hydroxyethyl) ) -p-phenylenediamine, p-nitro-o-phenylenediamine, p-phenylenediamine, m-phenylenediamine, N-phenyl-p-phenylenediamine, 2-hydroxy-5-nitro-2 ', 4'-diamino Azobenzene / sodium sulfate, toluene-2,5-diamine, 2- (2'-hydroxyethylamino) -5-aminotoluene, N, N-bis (β-hydroxyl) -p-phenylenediamine, N, N-bis (2-hydroxyethyl) -p-phenylenediamine sulfate 5-amino-o-cresol sulfate, p-aminophenol sulfate, o-chloro-p-phenylenediamine sulfate, 2- (2'-hydroxyethylamino) -5-aminotoluene sulfate, 4,4'-diaminodiphenylamine / sulfate, p-methylaminophenol / sulfate, p-phenylenediamine / sulfate, m-phenylenediamine / sulfate, toluene-2,5-diamine / sulfate, 2,4 -Diaminophenoxyethanol / hydrochloride, toluene-2,5-diamine / hydrochloride, m-phenylenediamine / hydrochloride, 2,4-diaminophenol / hydrochloride, 3,3'-iminodiphenol, p-phenylenediamine Hydrochloride, N-phenyl-p-phenylenediamine / hydrochloride, N-phenyl-p-phenylenediamine / acetate, 1,5-dihydroxynaphthalene, toluene-3,4-diamine, p-methylaminophenol, N, N'-bis (4-aminophenyl) -2,5 -Diamino-1,4-quinonediimine, o-aminophenol sulfate, 2,4-diaminophenol sulfate, m-aminophenol sulfate, 2-amino-4-nitrophenol, 2-amino-5- Nitrophenol, 1-amino-4-methylaminoanthraquinone, nitro-p-phenylenediamine hydrochloride, 1,4-diaminoanthraquinone, nitro-p-phenylenediamine, picramic acid, sodium picrate, 2-amino-5- Nitrophenol / sulfate, resorcinol, nitro-p-phenylenediamine / sulfate, p-nitro-o-phenylenediamine / sulfate, p-nitro-m-phenylenediamine / sulfate, red No. 2, red No. 3, Red No. 102, Red No. 104 (1), Red No. 105 (1), Red No. 106, Red No. 201, Red No. 227, Red No. 230 (1), Red No. 230 (2), Red 231 No., Red 23 No., red 401, red 502, red 503, red 504, red 506, yellow 4, yellow 5, yellow 202 (1), yellow 202 (2), yellow 203, Yellow 402, Yellow 403 (1), Yellow 406, Yellow 407, Orange 205, Orange 207, Orange 402, Green 3, Green 204, Green 205, Green 401, Green 402 No., Brown No. 201, Purple No. 401, Blue No. 1, Blue No. 2, Blue No. 202, Blue No. 203, Blue No. 205, Black No. 401, Red Cabbage Dye, Red Rice Dye, Akane Dye, Anato Dye, Ikasumi Dye , Turmeric, enju, krill, amber, caramel, gold, silver, gardenia, corn, onion, tamarind, spirulina, buckwheat, cherry, nori, hibi Cass pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin and other pigments and colorants, avocado oil, almond oil, fennel oil, egoma oil, olive oil, orange oil, orange rafa oil , Sesame oil, cacao butter, chamomile oil, carrot oil, cucumber oil, beef tallow fatty acid, kukui nut oil, safflower oil, shea fat, liquid shea fat, soybean oil, camellia oil, corn oil, rapeseed oil, persic oil, castor oil, Oils and fats such as cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, palm oil, palm kernel oil, owl, coconut oil, beef tallow, lard, and hydrogenated products (hardened oil etc.) of these oils, beeswax, Carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax, montan wax, shellac Waxes such as wax, rice wax, squalene, squalane, pristane, mineral oils such as liquid paraffin, petrolatum, paraffin, ozokelide, ceresin, microcristan wax, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, olein Natural fatty acids such as acid, linoleic acid, linolenic acid, docosahexaenoic acid, eicosapentaenoic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, lanolin fatty acid, isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2- Fatty acids such as methylpentanoic acid, 2-ethylhexanoic acid, isopentanoic acid and other synthetic fatty acids, ethanol, isopyropanol, lauryl alcohol, cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol , Phytosterols, natural alcohols such as phenoxyethanol, alcohols such as 2-hexyldecanol, isostearyl alcohol, synthetic alcohols such as 2-octyldodecanol, isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristic acid Myristyl, oleyl oleate, decyl oleate, octyldodecyl myristate, hexyldecyl dimethyloctanoate, diisobutyl adipate, 2-hexyldecyl adipate, diheptylundecyl adipate, N-alkylglycol monoisostearate, isocetyl isostearate, Trimethylolpropane triisostearate, ethylene glycol diethylhexanoate, neopentyl glycol diethylhexanoate, 2-ethylene Cetyl ruhexanoate, trimethylolpropane triethylhexanoate, pentaerythritol tetraethylhexanoate, cetyl octanoate, octyldodecyl gum, cetyl lactate, myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, monostearate Esters such as propylene glycol acid and propylene glycol dioleate, metal soaps such as aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate and zinc undecylenate, anions Surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate ester salt, alkyl phosphate ester salt), cation Surfactant (alkylamine salt, alkyl quaternary ammonium salt), amphoteric surfactant: carboxylic acid type amphoteric surfactant (amino type, betaine type), sulfate ester type amphoteric surfactant, sulfonic acid type amphoteric surfactant , Phosphate ester type amphoteric surfactant, nonionic surfactant (ether type nonionic surfactant, ether ester type nonionic surfactant, ester type nonionic surfactant, block polymer type nonionic surfactant, Nitrogen-containing nonionic surfactants), other surfactants (natural surfactants, derivatives of protein hydrolysates, polymer surfactants, surfactants containing titanium / silicon, fluorocarbon surfactants) ) And the like.

  Others, hormones, sequestering agents, pH adjusters, chelating agents, antiseptic / antibacterial agents, refreshing agents, stabilizers, emulsifiers, animal / plant proteins and their degradation products, animal / plant polysaccharides and their Degradation products, animal / plant glycoproteins and their degradation products, anti-inflammatory agents, antiallergic agents, wound treatment agents, foaming agents, thickeners, enzymes, purified water (electronic water, small clusters, etc.), deodorant / A deodorant etc. can be used in combination.

The dried white maple bark (450 g) was extracted three times with n-hexane (3 L) and filtered to obtain a residue. The residue was further extracted three times with methanol (3 L), and the filtrate after filtration was reduced under reduced pressure. The solvent was removed to obtain a methanol extract (63.5982 g). Methanol extract (25 g) was subjected to silica gel column chromatography, and elution was carried out by increasing the polarity of the solvent in order from n-hexane: ethyl acetate = 1: 0 to 0: 1, ethyl acetate: methanol = 1: 0 to 0: 1. And fractionated into fractions 1-9. Fraction 7 was fractionated by silica gel column chromatography and fractionated into 11 fractions 7-1 to 7-11. Among them, fraction 7-2 was separated by ODS-HPLC, and compound 8 (2.8 mg), compound 2 (4.6 mg), compound 5 (8.2 mg), compound 6 (3.2 mg) and compound 7 (5.9 mg) were separated. Obtained. Fraction 9 was subjected to silica gel column chromatography, and elution was carried out by increasing the polarity of the solvent sequentially from ethyl acetate: methanol = 4: 1 to 0: 1, and fractionated into fractions 9-1 to 9-5. Fraction 9-1 was separated by ODS-HPLC to give compound 4 (2.7 mg). Fraction 9-2 was separated by ODS column chromatography and fractionated into two fractions 9-2-1 and 9-2-2, and then fraction 9-2-2 was separated by ODS-HPLC, Compound 1 (79.0 mg), compound 9 (112.3 mg), and compound 3 (80.4 mg) were obtained. Each compound was identified by the following various structural analysis spectra. In addition, compounds 1 to 9 were obtained according to the same extraction and fractionation method using leaves or bark such as pearl maple, pine maple, ashberry maple, itayaka maple, megsurinoki, kusunoha maple, mitsodeka maple, negundo maple, mine maple (however, Yield is different).

Compound 8
ESI-MS m / z 323 [M + Na] ⁺ , 299 [MH] ⁻ , ¹ H-NMR (600 MHz, C ₅ D ₅ N) δ1.58 (1H, m, 5-H), 1.68 (2H, m, 4 and 6-H), 1.72 (3H, m, 4, 5 and 6-H), 1.98 (2H, m, 2-H ₂ ), 2.61 (2H, m, 7-H ₂ ), 2.89 ( 1H, m, 1-H), 3.04 (1H, m, 1-H), 3.88 (1H, br.d, J = 3.8 Hz, 3-H), 7.16 (2H, d, J = 8.6 Hz, 3 '' and 5 ''-H), 7.18 (2H, d, J = 8.6 Hz, 3 'and 5'-H), 7.19 (2H, d, J = 8.9 Hz, 2''and3''-H ), 7.29 (2H, d, J = 8.2 Hz, 2 'and 6'-H), ¹³ C-NMR (150 MHz, C ₅ D ₅ N) δ26.0 (5-C), 31.9 (1-C) , 32.5 (6-C), 35.5 (7-C), 38.4 (4-C), 40.8 (2-C), 70.3 (3-C), 116.2 (3 'and 5'-C or 3''and 5``-C), 116.3 (3 '' and 5 ''-C or 3 'and 5'-C), 129.9 (2' and 6'-C or 2 '' and 6``-C), 130.3 (2 '' and 6 ''-C or 2 'and 6'-C), 133.5 (1''-C), 133.8 (1'-C), 157.0 (4' and 4``-C).

Compound 1
HR-FAB-MS C ₂₅ H ₃₂ O ₈ Na [M + Na] ⁺ 483.1995, m / z 297 [MC ₆ H ₁₁ O ₅ ] ⁻ , ¹ H-NMR (400 MHz, C ₅ D ₅ N) δ1.00 (1H, m, 9-H), 1.12 (1H, m, 10-H), 1,26 (2H, m, 8,9-H), 1.39 (1H, m, 10-H), 1.50 (1H , m, 8-H), 1.71 (1H, m, 12-H), 2.13 (1H, m, 12-H), 2.42 (2H, m, 7-H ₂ ), 2.75 (1H, m, 13- H), 2.94 (1H, m, 13-H), 3.53 (1H, m, 11-H), 4.18 (1H, m, 5'-H), 4.43 (4H, m, 2 ', 3', 4 ', 6'-H), 4.59 (1H, dd, J = 11.8, 1.7 Hz, 6'-H), 5.85 (1H, d, J = 6.6 Hz, 1'-H), 5.94 (1H, d, J = 1.0 Hz, 6-H), 6.69 (1H, dd, J = 8.0, 1.0 Hz, 4-H), 6.97 (1H, dd, J = 8.1, 2.2 Hz, 16-H or 18-H), 7.21 (1H, d, J = 3.7 Hz, 15-H or 19-H), 7.24 (1H, d, J = 2.2 Hz, 16-H or 18-H), 7.29 (1H, dd, J = 8.3, 1.7 Hz, 15-H or 19-H), 7.55 (1H, d, J = 8.3 Hz, 3-H).

Compound 9
ESI-MS m / z 615 [M + Na] ⁺ , 591 [MH] ⁻ , ¹ H-NMR (400 MHz, C ₅ D ₅ N) δ0.86 (1H, m, 9-H), 1.08 (2H, m, 9,12-H), 1.22 (1H, m, 8-H), 1.43 (1H, m, 8-H), 1.54 (2H, m, 10,12-H), 2.36 (2H, m, 7,10-H), 2.50 (1H, m, 7-H), 2.87 (1H, m, 13-H), 3.14 (1H, m, 13-H), 3.57 (1H, m, 11-H) , 4.02 (1H, m, 2'-H), 4.11 (2H, m, 4 ', 5'-H), 4.14 (2H, s, 5``-H), 4.23 (2H, m, 3', 6'-H), 4.35 (1H, d, J = 9.3 Hz, 4``-H), 4.60 (1H, d, J = 9.3 Hz, 4``-H), 4.77 (1H, d, J = 2.1 Hz, 2``-H), 4.80 (2H, m, 1 ', 6'-H), 5.75 (1H, d, J = 2.4 Hz, 1``-H), 5.99 (1H, d, J = 2.1 Hz, 6-H), 6.72 (1H, dd, J = 7.9, 2.1 Hz, 4-H), 7.22 (3,16,18-H are overlapped with solvent siganl), 7.27 (1H, d, J = 7.9 Hz, 15-H or 19-H), 7.75 (1H, d, J = 8.2 Hz, 15-H or 19-H).

Compound 2
ESI-MS m / z 335 [M + Na] ⁺ , 311 [MH] ⁻ , ¹³ C-NMR (150 MHz, C ₅ D ₅ N) δ28.7 (7-C), 31.6 (13-C), 36.5 (8-C), 44.8 (12-C), 53.5 (10-C), 65.2 (9-C), 117.8 (3-C), 118.0 (6-C), 123.4 (4-C), 123.8 ( 16 and 18-C), 130.4 (15 or 19-C), 132.2 (19 or 15-C), 132.5 (5-C), 137.7 (14-C), 146.0 (2-C), 150.9 (1- C), 157.9 (17-C), 212.5 (11-C).

Compound 3
ESI-MS m / z 483 [M + Na] ⁺ , 495 [M + Cl] ⁻ , ¹ H-NMR (400 MHz, C ₅ D ₅ N) δ0.96 (1H, m, H-10), 1.18 (1H, m, H-11), 1.48 (3H, m, H-10,11 and 12), 1.66 (1H, m, H-8), 1.68 (1H, m, H-12), 1.73 (1H , m, H-8), 2.48 (1H, m, H-13), 2.64 (1H, m, H-13), 2.69 (1H, m, H-7), 2.99 (1H, m, H-7 ), 5.82 (1H, d, J = 4.4 Hz, H-1 '), 6.73 (1H, d, J = 8.1 Hz, H-4), 6.91 (1H, d, J = 8.3 Hz, H-16 or 18), 7.11 (1H, d, J = 8.3 Hz, H-15 or 18), 7.54 (1H, d, J = 8.3 Hz, H-3).

Compound 4
ESI-MS m / z 481 [M + Na] ⁺ , 457 [MH] ⁻ , ¹³ C-NMR (100 MHz, C ₅ D ₅ N) δ20.6 (C-9), 27.7 (C-8), 31.6 (C-7), 32.1 (C-13), 44.5 (C-12), 45.9 (C-10), 62.3 (C-6 '), 71.4 (C-4'), 74.4 (C-2 ' ), 78.3 (C-5), 78.5 (C-3), 102.4 (C-1), 117.5 (C-3), 119.0 (C-6), 122.4 (C-4), 123.6 (C-16 and 18), 130.5 (C-15 or 19), 130.9 (C-19 or 15), 134.6 (C-5), 137.6 (C-14), 145.5 (C-2), 151.8 (C-1), 157.9 (C-17), 210.7 (C-11).

Compound 5
ESI-MS m / z 321 [M + Na] ⁺ , 297 [MH] ⁻ , ¹ H-NMR (400 MHz, C ₅ D ₅ N) δ1.01 (1H, m, H-9), 1.13 (1H , m, H-10), 1.28 (2H, m, H-8 and 9), 1.40 (1H, m, H-10), 1.53 (1H, m, H-8), 1.72 (1H, m, H -12), 2.14 (1H, m, H-12), 2.47 (2H, m, H ₂ -7), 2.76 (1H, m, H-13), 2.95 (1H, m, H-13), 3.54 (1H, m, H-11), 5.97 (1H, d, J = 2.0 Hz, H-6), 6.75 (1H, dd, J = 8.1, 2.0 Hz, H-4).

Compound 6
ESI-MS m / z 321 [M + Na] ⁺ , 297 [MH] ⁻ , ¹ H-NMR (400 MHz, C ₅ D ₅ N) δ0.79 (1H, m, H-10), 1.00 (1H , m, H-11), 1.23 (1H, m, H-10), 1.30 (1H, m, H-11), 1.50 (2H, m, H ₂ -8), 1.53 (1H, m, H- 12), 1.76 (1H, m, H-12), 2.57 (1H, m, H-7), 2.63 (2H, m, H-7 and 13), 2.80 (1H, m, H-13), 3.07 (1H, m, H-9), 5.57 (1H, d, J = 1.8 Hz, H-6), 6.63 (1H, dd, J = 8.2, 1.8 Hz, H-4), 6.84 (1H, d, J = 8.2 Hz, H-3), 6.93 (1H, dd, J = 2.5, 8.2 Hz, H-16 or 18), 7.13 (1H, dd, J = 2.5, 8.2 Hz, H-18 or 16), 7.23 (1H, dd, J = 2.1, 8.2 Hz, H-15 or 19), 7.30 (1H, dd, J = 2.1, 8.2 Hz, H-19 or 15).

Compound 7
ESI-MS m / z 297 [MH] ⁻ , ¹ H-NMR (400 MHz, C ₅ D ₅ N) δ1.45 (1H, m, 11-H), 1.74-1.83 (2H, m, 11, 12- H), 1.90 (1H, m, 10-H), 1.95-2.10 (3H, m, 8,10,12-H), 2.46 (1H, m, 8-H), 2.51 (1H, m, 13- H), 2.88 (1H, d, J = 16.8 Hz, 13-H), 3.00 (1H, d, J = 17.1 Hz), 3.34 (1H, m, 7-H), 4.49 (1H, t, J = 9.5 Hz, 9-H), 7.13-7.22 (4H, m, 4,5,15,16-H), 7.48 (1H, br.s, 18-H), 7.6 (br.s, 19-H: overlapped with solvent signal).

(Test 1) Melanin production inhibitory effect test
B16 melanoma cells are mouse-derived melanin producing cells, and a drug that suppresses the production of melanin in these cells can be expected to lighten the skin color, that is, to whiten.
[Test method and evaluation method]
B16 melanoma cells were cultured for 24 hours, and this culture medium was replaced with a culture medium to which a sample was added. At this time, purified water was added to the blank. After culturing for 3 days, the cells were treated with trypsin, heated and dissolved in a 1N-NaOH solution containing 10% DMSO, and the absorbance at 420 nm was measured to obtain the amount of melanin. Simultaneously, the number of cells was measured by the MTT reduction method (Tim Mosmann; Journal of Immunological Methods p55-63 (1983) reference), and it was confirmed that there was no difference in the number of viable cells between the blank group and the sample addition group.

[sample]
Compounds 1 to 9, which are diarylheptanoid derivatives, and a methanol extract from the extracted residue of Megurono bark n-hexane were dissolved in DMSO so as to have a final solid content concentration of 25 ppm and subjected to the test. DMSO solution was used as a blank. As a control for comparison, an arbutin (Sigma) DMSO solution having the same solid content concentration was used.
[Test results]
As shown in FIG. 1, a methanol extract from a diarylheptanoid derivative of the present invention and a residue obtained from extraction with n-hexane bark of bark has a strong melanin inhibitory effect comparable to or higher than that of arbutin. It was confirmed that it could be used as a production inhibitor. In addition, the melanocyte cytotoxicity was not recognized by the sample.

(Test 2) Stability Test In order to evaluate the stability of the melanin production inhibitor of the present invention, the sample was left in a 60 ° C. environment, and color change, occurrence of starch, etc. were confirmed.
[sample]
Prepare 0.1% DMSO solution of methanol extract or ethanol extract from n-hexane extract residue of compound 1-9, Japanese maple, maple, medulinary tree, Itaya maple, and store at 60 ° C in a constant temperature bath. Changes were observed.
[Test results]
All the samples were confirmed to be stable with no change in color tone, occurrence of starch, or odor.

(Test 3) Safety test (1) Skin primary irritation test A Hartley guinea pig (female, 3 per group) prepared by preparing a solution of the compound 1-9 mixture to about 0.1% and shaving the back 0.03 mL was applied to each animal per 2 × 2 cm ² of skin weighing approximately 340 g). Judgment was performed 24, 48, and 72 hours after application using the primary irritation scoring method with erythema and edema as indicators. As a result, in all animals, no erythema and edema were observed, and it was judged negative.

(2) Cumulative skin irritation test Hartley guinea pigs (female, 3 per group) prepared by preparing a solution of the compound 1-9 mixture at about 0.1% and shaving the flank (2 × 2 cm ² ) 0.03 mL was applied to each animal once a day, 5 times a week, per 2 × 2 cm ² of skin (weight approximately 320 g). Application was performed over 2 weeks, and shaving was performed in a timely manner. Judgment was made on the day of each application and the day after the last application by the scoring method of primary irritation using erythema and edema as indices. As a result, in all the animals, no erythema and edema were observed for 2 weeks after application, and the animals were judged negative.

(3) Single-dose toxicity test ddy mice (male and female, 5 animals per group,) in which a mixture of compounds 1 to 9 was fasted for 16 hours before the test in an amount of 2,000 mg / kg (body weight) per animal. 5 weeks old) was orally administered, and the onset and degree of toxic symptoms were observed over time. As a result, no abnormalities were observed in all mice for 14 days, and no abnormalities were found in the anatomical results. Therefore, Compounds 1-9 were determined to be safe substances.

[Production Examples] Production of various skin external preparations and foods and beverages According to the above evaluation results, the following formulation examples are shown. Each formulation example may be produced by a conventional method in the production of each product, and only the blending amount is shown. Indicated. The present invention is not limited to these.

(Formulation Example 1) Milk Mass%
1. Squalane
5.0
2. Olive oil
5.0
3. Jojoba oil
5.0
4.Cetyl alcohol
1.5
5.Glycerin monostearate
2.0
6. Polyoxyethylene (20) cetyl ether
3.0
7. Polyoxyethylene (20) soorbitan monooleate
2.0
8.1,3-Butylene glycol
1.0
9.Glycerin
2.0
10. Any of compounds 1-9 or any mixture 0.001

11. Preservative (paraoxybenzoic acid ester) appropriate amount
12. Fragrance
Appropriate amount
13. Residue with 100 purified water

(Formulation Example 2) Milk Mass%
1. Squalane
8.0
2. Jojoba oil
7.0
3.Glyceryl paraaminobenzoate 1.0

4. Ethyl urocanate
1.0
5. Vitamin C phosphate magnesium salt
1.0
6.Cetyl alcohol 1.5

7. Glycerin monostearate 2.0

8.Polyoxyethylene (20) cetyl ether 3.0

9. Polyoxyethylene (20) soorbitan monooleate
2.0
10.1,3-Butylene glycol 1.0

11.Glycerin
2.0
12.1,2-Pentanediol 3.0

13. Any of compounds 1-9 or any mixture 0.001

14. Green tea 20% ethanol extract
2.0
15. Murasaki (purple) root 50% propylene glycol extract 1.0

16. Silk Protein Enzyme Decomposition Solution
1.0
17. Antibacterial / preservative (paraoxybenzoic acid ester) appropriate amount
18.Residual water 100

(Formulation Example 3) Cosmetic Oil Mass%
1.liquid paraffin 30.0
2.Squalane 20.0
3.Olive oil 20.0
4.Isopropyl palmitate 10.0
5. Any of compounds 1-9 or any mixture 0.001

6. Grapefruit fruit or leaf hot water extract
1.0
7. Soybean seed hot water extract
1.0

8. Olive oil
1.0
9. Shea fat
1.0

10.Butylhydroxyanisole
0.1
11. Vitamin E derivatives
0.1
12. Antibacterial and antiseptic (phenoxyethanol)
Appropriate amount

13. Fragrance (rose water)
Appropriate amount
14. Residue with 100 purified water

(Formulation example 4) Flexible lotion mass%
1.Glycerin 5.0

2.1,3-Butylene glycol 5.0

3.Polyoxyethylene sorbitan monolaurate (20E.O) 1.0
4.Ethanol 15.0
5. Tokachinka flower 30% 1,3-butylene glycol extract
2.0
6. Bodhi tree flower or fruit 50% 1,3-butylene glycol extract 1.0

7. Any of compounds 1-9 or any mixture 0.001

8. Cuckon 20% 1,3-butylene glycol extract 1.0

9. Antibacterial and antiseptic (paraoxybenzoic acid ester) appropriate amount
10. Fragrance (Western light load water)
Appropriate amount
11. Residue with 100 purified water

(Formulation Example 5) Astringent lotion
1.Sorbit 2.0

2.POE (20) oleyl alcohol
1.0
3.Ethanol 15.0
4.1,2-Pentanediol 3.0

5. Ginkgo biloba 30% ethanol extract
3.0
6. Horsetail 50% ethanol extract
2.0
7. 50% 1,3-butylene glycol extract
2.0
8. Gentian whole plant 50% ethanol extract
2.0
9. Camelis leaf or bark 50% 1,3-butylene glycol extract
1.0
10. Any of compounds 1-9 or any mixture 0.001

11. Cucumber fruit 50% propylene glycol extract 1.0

12. Yeast 50% 1,3-butylene glycol extract
1.0
13. Allantoin 0.1

14. Astringent (Zinc Sulfocolate)
0.2
15. Antibacterial and antiseptic (thiamin lauryl sulfate)
Appropriate amount
16. Fragrance (lavender water)
Appropriate amount
17.Residue with 100 purified water

(Prescription Example 6) Two-layer lotion (liquid to liquid type)
1. Squalane 8.0

2.POE sorbitan tetraoleate
0.3

3. Sorbitol 1.0

4.Ethanol 15.0
5. Hawthorn fruit 70% propylene glycol extract
3.0
6. Spruce 50% propylene glycol extract
3.0
7. Gentian rhizome 70% propylene glycol extract
3.0
8. Any of compounds 1-9 or any mixture 0.001

9. Acacia rhizome or root bark 50% propylene glycol extract 2.0

10. Green tea leaf or stem 50% 1,3-butylene glycol extract
2.0
11. Sage whole plant 50% ethanol extract
1.0
12. Western bodhi tree flower or fruit 30% ethanol extract
1.0

13.Ascorbic acid glucoside 0.2

14. Astringent (calamine)
0.1
15. Antibacterial and antiseptic (phenoxyethanol)
Appropriate amount

16. Fragrance (apple water)
Appropriate amount
17.Residue with 100 purified water

(Formulation example 7) Carmine lotion (liquid to solid type)
1.Glycerin 3.0

2.1,3-Butylene glycol 5.0

3.Ethanol 15.0
4. Iron oxide (Bengara)
0.2
5.Zinc oxide 0.5

6.Kaolin 2.0

7. Rhizome rhizome 30% propylene glycol extract 3.0

8. Sanshishi fruit 50% propylene glycol extract
3.0
9. Shark root 50% propylene glycol extract 2.0

10. Usvenia mallow flower or leaf 50% propylene glycol extract
2.0
11. Chamomile flower 50% propylene glycol extract 2.0

12. Comfrey leaves and stems 50% ethanol extract
1.0
13. Fuquitan poppo flower or leaf 50% 1,3-butylene glycol extract 1.0

14. Any one or any mixture of compounds 1-9 0.001

15. Silk protein alkaline solution
2.0

16.Camphor 0.2

17.Phenol
0.03
18. Antibacterial and antiseptic (photosensitive element 201 & 401)
Appropriate amount

19. Fragrance (Bodhi Tree Water)
Appropriate amount
20.Residue with 100 purified water

(Formulation example 8) Pack mass%
1. Polyvinyl alcohol
15.0

2.Carboxymethylcellulose sodium
5.0
3.Propylene glycol 3.0

4.Ethanol 10.0
5. Any of compounds 1-9 or any mixture 0.001

6. Ginseng root 30% ethanol extract 1.0

7. Stem or leaf 30% ethanol extract 1.0

8. Wenzhou tangerine peel 50% 1,3-butylene glycol extract 1.0

9. Peach leaf hot water extract
1.0

10. Yeast 50% 1,3-butylene glycol extract
1.0
11. Antibacterial and antiseptic (paraoxybenzoic acid ester)
Appropriate amount

12. Fragrance (rose water)
Appropriate amount

13. Residue with 100 purified water

(Formulation example 9) Peel-off pack mass%
1.Glycerin 5.0

2.Propylene glycol 4.0

3.Polyvinyl alcohol 15.0
4.Ethanol 8.0

5.Polyoxyethylene glycol 1.0

6. Pantothenyl ethyl ether 1.0

7. Any of compounds 1-9 or any mixture 0.001

8. Dutch jelly (parsley) leaves or stems 50% ethanol extract 1.0

9. Eucalyptus leaf or stem 30% ethanol extract
1.0

10. Royal jelly 50% ethanol extract 1.0

11. Trehalose solution 1.0

12. Antibacterial and antiseptic (paraoxybenzoic acid ester)
Appropriate amount
13. Fragrance (camomile water)
Appropriate amount
14. Residue with 100 purified water

(Prescription Example 10) Cold cream mass%
1. Sarah beeswax
11.0
2. Liquid paraffin
22.0
3. Lanolin
10.0
4. Olive oil
5.0

5. Chamomile oil
5.0

6. Palm oil
5.0
7. Borax
0.5

8. Any of compounds 1-9 or any mixture 0.001

9. Achillea millefolium whole plant extract
2.0

(Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent)

10. Birch bark extract
2.0
(Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent)

11. Ginseng root 50% propylene glycol extract 2.0

12. Soybean seed water extract
1.0

13. Liquid shea fat
1.0

14.Dipotassium glycyrrhizinate
0.1
15. Antibacterial and antiseptic (Acrinol)
0.1
16. Fragrance (ylang ylang water)
Appropriate amount

17.Residue with 100 purified water

(Formulation example 11) Emollient cream mass%
1.Stearic acid 2.0

2. Stearyl alcohol
7.0
3. Reduced lanolin
2.0
4.Squalane 5.0

5. Octyldodecanol
6.0
6. Polyoxyethylene cetyl ether (25E.O.)
3.0
7. Lipophilic glyceryl monostearate 2.0

8.Propylene glycol 2.0

9.1,2-Pentanediol 2.0

10. Any of compounds 1-9 or any mixture 0.001

11. Hawthorn peel 50% dipropylene glycol extract 2.0

12. Shiso leaves 50% propylene glycol extract
2.0
13. Murasaki (purple) root 50% propylene glycol extract 2.0

14. Soybean seed natto fermentation liquid
1.0

15.Glycyrrhetinic acid
0.1
16. Antibacterial (Lactoferrin solution)
0.5
17. Antibacterial and antiseptic (zinc pyridione) appropriate amount
18. Fragrance (mugwort water)
Appropriate amount

19.Residue with 100 purified water

(Formulation example 12) Facial cleansing cream mass%
1.Myristic acid
25.0
2. Stearic acid
5.0

3. Tallow fatty acid
5.0
4.Propylene glycol
10.0
5. Potassium hydroxide
6.0
6. Palm oil fatty acid diethanolamide
6.0
7. Any of compounds 1-9 or any mixture 0.001

8. Apple fruit 20% 1,3-butylene glycol extract 1.0

9. Rosehip fruit 30% ethanol extract
1.0

10.Kakkon hot water extract
1.0

11.Glycyrrhizic acid
1.0

12.Apricot kernel 0.1

13. Walnut shell
0.1
14. Antibacterial and antiseptic (2-phenoxyethanol)
0.1
15. Fragrance (to return water)
Appropriate amount
16.Residue with 100 purified water

(Prescription Example 13) Face-wash cream%
1. Stearic acid
10.0

2. Palmitic acid
10.0

3.Myristic acid 12.0
4.Lauric acid 4.0

5.Glycerin
18.0

6. dl-Pyrrolidonecarboxylate solution 1.0
7.Dioctyl adipate1.0

8.Cetostearyl alcohol 3.0

9.Triethanolamine 3.0

10.Ergocalcifer 1

11.Oleyl alcohol
1.5
12. Lanolin derivative (EO adduct) 1.0

13.Potassium hydroxide 6.0

14. Any one or any mixture of compounds 1-9 0.001

15. Royal Jelly Extract 1.0

(Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent)

16. Oil-soluble chamomile flower or leaf extract 1.0

(Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent)

17. Oil-soluble licorice root or rhizome extract 1.0

(Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent)

18. Edetate 1.0

19.Glycyrrhizic acid
1.0

20.Corn cob grain 0.1

21. Teut Walnut Shell Grain 0.1

22. Antibacterial and antiseptic (photosensitive element 401) 0.1

23. Fragrance (mugwort water)
Appropriate amount
24. The balance of 100 purified water

(Prescription Example 14) Body soap mass%
1. Potassium laurate
15.0

2. Potassium myristate
5.0
3.Propylene glycol
5.0
4.Alkanediol
1.0
5. Oyster persimmon 50% ethanol extract
4.0
6. Horseshoe leaf 70% 1,3-butylene glycol extract
0.5
7. Ginkgo biloba leaf 70% 1,3-butylene glycol extract
0.5
8. Any of compounds 1-9 or any mixture 0.001

9. Aloe pulp
1.0

10.Polyethylene powder
0.5
11.Hydroxypropyl chitosan solution
0.5
12. Amino acids (Arginine, Glycine, Glutamine, etc.)
0.5
13. Monoammonium glycyrrhizinate
0.1
14. Antibacterial and antiseptic (undecylenic acid, phenol)
Appropriate amount
15.pH adjuster
Appropriate amount

16. Fragrance (lavender water)
Appropriate amount
17.Residue with 100 purified water

(Prescription Example 15) Body soap mass%
1. Potassium laurate
15.0

2. Potassium myristate
5.0
3.Propylene glycol
5.0
4. Roman chamomile head flower 50% 1,3-butylene glycol extract
3.0
5. Any of compounds 1-9 or any mixture 0.001

6. Toki rhizome 70% 2,3-butylene glycol extract
0.5
7. Chlorella 70% 1,3-butylene glycol extract
0.5
8. Fish (sea bream or flounder) derived hydrolyzed collagen solution
0.5
9. Amino acids (glutamine, proline, lysine, etc.)
0.5
10. Monoammonium glycyrrhizinate
0.1
11. Antibacterial and antiseptic (undecylenic acid, phenoxyethanol)
12.pH adjuster
Appropriate amount

13. Fragrance (orange water)
Appropriate amount
14. Residue with 100 purified water

(Formulation Example 16) Sunscreen cosmetics (O / W type)
1. Oxybenzone
2.0

2. Octyl paramethoxycinnamate
5.0
3.Dihydroxymethoxybenzophenone
0.2
4. Squalane
10.0

5. Vaseline
5.0

6. Stearyl alcohol
3.0

7. Stearic acid
3.0

8. Glyceryl monostearate
2.0
9. Polyethyl acrylate
1.0
10.1,3-Butylene glycol 6.0

11. Edetate disodium 0.1

12.Triethanolamine
1.0
13.Titanium dioxide 5.0

14. Any one or any mixture of compounds 1-9 0.001

15. Birch bark 70% dipropylene glycol extract 1.0

16. Cornflower leaf 50% propylene glycol extract
0.5

17. Kakkon 50% propylene glycol extract
0.5

18. Zushi fruit 50% dipropylene glycol extract 0.5

19. Antibacterial and antiseptic (benzyl paraoxybenzoate)
Appropriate amount
20. Fragrance (jasmine water)
Appropriate amount
21. The balance of 100 purified water

(Formulation example 17) Sunscreen cosmetics (oil type)
1. Liquid paraffin
70.0
2. Tetrahydroxybenzophenone
1.0
3.Cetyl octanoate
19.8
4. Any of compounds 1-9 or any mixture 0.001

5. Chamomile flower 10% 1,3-butylene glycol extract
1.0
6. Horse chestnut whole plant 30% 1,3-butylene glycol extract
0.5
7. Mallow flower or leaf 50% propyl alcohol extract
0.5
8. Whole barley 50% 1,3-butylene glycol extract 0.5

9.Merirot flower or leaf 70% 1,3-butylene glycol extract
0.5
10.Ethyl paraaminobenzoate
0.2
11. Antioxidant (Butylhydroxytoluene)
Appropriate amount
12. Perfume
Appropriate amount

(Prescription Example 18) Cream foundation (O / W type) Mass%
1. Stearic acid
4.0
2. Glycerol monostearate
3.0
3.Cetanol
1.5
4.Isopropyl myristate
7.0
5. Liquid paraffin
10.0

6. Sarah Beeswax
3.0
7. Triethanolamine
1.5
8.Glycerin
3.0
9. Bentonite
1.0
10. Titanium oxide
8.0
11.2,4-Dihydroxybenzophenone
8.0
12.Kaolin
3.0
13. Talc
3.0
14. Colored pigment (yellow iron oxide)
1.0
15. Ezoukogi root bark 70% 1,3-butylene glycol extract
1.0
16. Spruce peel 70% 1,2-pentanediol extract
1.0
17. Dokudami leaf hot water extract dry powder
0.3
18. Yukinoshita whole plant hot water extract dry powder 0.3

19. Any one or any mixture of compounds 1-9 0.001

20. Antibacterial and antiseptic (phenoxyethanol) 0.1

21. Fragrance (rose water) appropriate amount
22.Residue with 100 purified water

(Prescription Example 19) Shampoo Mass%
1.Lauryl sulfate triethanolamine 5.0

2. Sodium polyoxyethylene lauryl ether sulfate 12.0
3.1,3-Butylene glycol
4.0
4.Lauric acid diethanolamide 2.0

5. Edetate disodium 0.1

6. Any of compounds 1-9 or any mixture 0.001

7. Large-scaled crape myrtle 20% 2,3-butylene glycol extract 2.0

8.Hyperum root bark or rhizome hot water extract 2.0

9. 30% spikelet or rhizome 1,3-butylene glycol extract
2.0
10. Toki 30% 1,3-butylene glycol extract
2.0
11. Tomato fruit hot water extract
1.0

12.Hydroxypropyl chitosan solution
1.0
13. Hyaluronic acid solution
1.0
14.Dipotassium glycyrrhizinate
0.1
15. Antibacterial and antiseptic (photosensitive element 101)
Appropriate amount
16.pH adjuster
Appropriate amount
17. Fragrance (white sand water)
Appropriate amount

18.Residual water 100

(Prescription Example 20) Rinse
mass%
1. Stearyltrimethylammonium chloride
3.0
2.cetostearyl alcohol
3.0
3.Polyoxyethylene lanolin ether
3.0
4.Propylene glycol
5.0
5.1,2-Pentanediol
2.0
6.Sugi grass whole plant 50% 1,2-pentanediol extract
3.0
7. White willow leaves 50% 2,3-butylene glycol extract
3.0
8. Any of compounds 1-9 or any mixture 0.001

9. Tokachinka flower 50% 1,3-butylene glycol extract
1.0
10. Perfumed fruit 30% 1,3-butylene glycol extract
1.0
11. Yellow rhizome 50% 1,3-butylene glycol extract
1.0
12. Comfrey leaves or stem 50% 1,3-butylene glycol extract
1.0

13. Soybean seed natto fermentation liquid
0.5

14.4% hydroxyethyl chitosan solution
0.5

15. Fish (carp or carp) derived collagen solution
0.5
16.30% trehalose solution 0.5

17. Hydrolyzed silk solution 0.5

18. Antibacterial and antiseptic (benzalkonium chloride)
Appropriate amount
19. Fragrance (Water)
Appropriate amount
20.Residue with 100 purified water

(Prescription Example 21) Rinse Mass%
1. Stearyltrimethylammonium chloride
2.0
2.cetostearyl alcohol
2.0
3.Polyoxyethylene lanolin ether
3.0
4.Propylene glycol
5.0
5.Ethylene glycol
3.0
6. Any of compounds 1-9 or any mixture 0.001

7. 50% 1,3-butylene glycol extract
1.0
8. Western bodhi tree flower or fruit 50% 1,4-butylene glycol extract
1.0
9. Olive leaf 50% 1,2-butylene glycol extract
1.0
10. Mugge fruit or flower 50% 1,3-butylene glycol extract 1.0

11. Sweet tea whole plant 50% glycerin extract 1.0

12. Bifidobacterium fermentation broth
1.0

13.Sodium alginate 1.0

14.30% trehalose solution 1.0

15. Hydrolyzed keratin solution 1.0

16. Antibacterial and antiseptic (benzalkonium chloride)
Appropriate amount

17. Fragrance (camomile water)
Appropriate amount
18.Residual water 100

(Formulation Example 22) Hair Liquid Mass%
1.Ethanol 29.0
2.Polyoxypropylene butyl ether phosphate 10.0
3.Polyoxypropylene monobutyl ether 5.0

4. Triethanolamine
1.0
5. Sanshishi fruit 30% 1,3-butylene glycol extract
3.0
6. Any of compounds 1-9 or any mixture 0.001

7.Hop female flower ear 50% ethanol extract
1.0

8. Melissa whole plant 50% ethanol extract
1.0

9. Usbasaicin rhizome 30% ethanol extract 1.0

10.4% hydroxypurpyruchitosan solution
3.0

11.Carpronium chloride 0.2

12. Hinokitiol 0.5

13.Keratin degradation solution 0.5

14. Stearyl glycyrrhetinate
0.1
15. Antibacterial and antiseptic (paraben, benzalkonium chloride)
Appropriate amount

16. Fragrance (rose hip water)
Appropriate amount

17.Residue with 100 purified water

(Prescription example 23) Hair artnic mass%
1.Ethanol 40.0
2.Ethyl oleate 1.0

3.Polyoxyethylene (40) hydrogenated castor oil 2.0

4. Gentian rhizome 30% ethanol extract
3.0
5. Lime fruit 30% ethanol extract 1.0

6. Any of compounds 1-9 or any mixture 0.001

7. Antibacterial and antiseptic (propyl paraoxybenzoate) 0.2

8. Residue with 100 purified water

(Prescription Example 24) Hair growth / hair growth agent
mass%
1.Ethanol
60.0

2. Ginkgo leaf 50% glycerin extract 5.0

3. Any one or any mixture of compounds 1-9 0.001

4. Vitamin E derivatives
0.5
5.Pepper tincture 0.5

6.Resorcin 0.5

7.Dipotassium glycyrrhizinate 0.5

8.Carboxymethylchitin solution 0.5

9. Collagen protein enzyme solution 1.0

10. Porcine hematin solution
0.5
11. Porcine mucin solution
0.5
12. Amino acids (Arginine, Glycine, Glutamine, etc.)
0.5
13. Antibacterial and antiseptic (paraben)
0.1
14. Fragrance (rosemary water)
Appropriate amount
15. Residue with 100 purified water

(Prescription Example 25) Hair growth / hair growth agent
1.Ethanol 60.0
2. Any of compounds 1-9 or any mixture 0.001

3.Hyperum root bark or rhizome hot water extract 3.0

4. Whole plant 60% ethanol extract
3.0

5. Peony rhizome or root bark 60% ethanol extract 3.0

6. Any of compounds 1-9 or any mixture 0.001

7. Soybean seed natto fermentation liquid
1.0

8. 20% 1,3-butyleneglycol extract from the plant of Crape myrtle 1.0

9. Hot pepper extract with hot water
1.0

10. Cantalis tincture
0.5
11. Pantothenic acid derivative 0.2

12.β-Glycyrrhetinic acid 0.2

13.Resorcin 0.2

14.4% hydroxyethyl chitosan solution
0.2

15.Elastin hydrolyzate
0.2

16. Keratin protein enzymatic solution
0.2

17. Preservative (Methyl paraoxybenzoate)
0.1
18. Fragrance (bergamot water)
Appropriate amount

19.Residue with 100 purified water

(Formulation Example 26) Granule bath agent
1. Sodium bicarbonate
58.0

2.Anhydrous sodium sulfate
30.0

3. Borax
5.0
4. Any one or any mixture of compounds 1-9
4.5
5. Sorbitol
1.0
6. Peach leaf 70% ethanol extract dry powder
1.0
7. Black tea leaf 30% ethanol extract dry powder
1.0

8. Dye (Gungjo Green)
0.5

(Prescription Example 27) Granule bath agent
1. Sodium bicarbonate
58.0

2.Anhydrous sodium sulfate
30.0
3. Borax
3.0

4. Any one or any mixture of compounds 1-9
3.0
5. Hawthorn fruit hot water extract dry powder
1.0
6. Horsetail whole plant hot water extract dry powder
1.0
7. Roman chamomile head flower hot water extract dry powder
1.0
8. Orange peel 50% ethanol extract
1.0
9. Apple fruit juice powder
1.0
10. Dye (Gunjou, chromium hydroxide)
Appropriate amount

11. Fragrance (Water)
Appropriate amount

(Prescription example 28) Mentsuyu mass%
1. Soy sauce
80.0

2.Black vinegar
2.0

3.Glucose 13.0
4.Sodium glutamate
2.0
5. Any one or any mixture of compounds 1-9
3.0

(Prescription example 29) Udon or buckwheat
1. Wheat flour and / or buckwheat flour 95.0
2. Salt
1.0
3. Any one or any mixture of compounds 1-9
4.0

(Prescription Example 30) Beverage Mass%
1.Glucose liquid sugar 30.0
2. Grapefruit juice 25.0
3. Any one or any mixture of compounds 1-9
2.0
4. Iyokan Juice 5.0

5.Fructose 4.0

6. Fragrance
Appropriate amount

7. Acidulant
Appropriate amount

8. Residue with 100 purified water

(Prescription Example 31) Bread Mass%
1. Flour
65.0

2.East
2.0

3. Salt
1.0
4. Any one or any mixture of compounds 1-9
3.0
5. Vitamin E
0.1
6. Heme iron
0.8
7. Benzoic acid
0.1
10. Purified water
28.0

(Prescription Example 32) Sausage
mass%
1. Minced meat 80.0
2. Egg 10.0
3. Spice
2.0
4.Seasoning
2.0
5. Any one or any mixture of compounds 1-9
2.0
6. Capsicum extract
4.0

(Prescription Example 33) Gum
mass%
1.Gum base 80.0
2. Minamata
10.0
3.Mentholmicron 4.0

4. Grapefruit flavor 2.0

5. Lemon Flavor 2.0

6. Any one or any mixture of compounds 1-9
2.0

(Prescription Example 34) Miso Soup
mass%
1. Tofu
20.0
3.Carrot 8.0

4. Burdock
8.0
5. Chinese cabbage
5.0
6. Fried fish 5.0

7.Red miso
10.0
8. Any one or any mixture of compounds 1-9
2.0
9.bonito stock 5.0

10. Residue with 100 purified water

(Prescription Example 35) Cookie
mass%

1. Flour
40.0

2.Butter 20.0
3. Sugar
20.0

4. Whole egg
8.0
5. Constarch
5.0
6. Milk
3.5
7.Salt 0.5

8. Any one or any mixture of compounds 1-9
2.0
9. Fragrance
Appropriate amount

(Test 4) Use effect test The effect at the time of actually using the skin external preparation of this invention was examined. The usage test was conducted by three sets of panelists consisting of 10 people aged 30 to 60 years, washing the left and right arms twice daily in the morning and night, and then applying the emulsion of Prescription Example 1 to the right arm and the left arm. Then, an appropriate amount of the control emulsion was applied over 3 months. In addition, the control used what replaced the diaryl heptanoid derivative of this invention with the purified water from the emulsion. The evaluation method is based on the following criteria, and the results are as shown in Table 1. The numerical values in the table represent the number of people. No one complained of skin abnormalities during the period of use.

“Blemish / Sobacus & Skin Color Improvement”
Effective: Blemish and freckles and skin color improved to white.
Slightly effective: Blemish freckles and skin color improved to white.
Invalid: No change before use.

It is a figure which shows the melanin production inhibitory effect of the diaryl heptanoid derivative of this invention. (Example 2)

Claims (1)

A melanin production inhibitor comprising at least one selected from diarylheptanoid derivatives of compounds 1 to 6 represented by general formula 1 and compound 7 represented by general formula 2 .

Images