JP2006067889A5 - - Google Patents
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- Publication number
- JP2006067889A5 JP2006067889A5 JP2004254824A JP2004254824A JP2006067889A5 JP 2006067889 A5 JP2006067889 A5 JP 2006067889A5 JP 2004254824 A JP2004254824 A JP 2004254824A JP 2004254824 A JP2004254824 A JP 2004254824A JP 2006067889 A5 JP2006067889 A5 JP 2006067889A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl
- nucleic acid
- polyion complex
- peo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000007523 nucleic acids Chemical class 0.000 claims description 19
- 108020004707 nucleic acids Proteins 0.000 claims description 17
- 102000039446 nucleic acids Human genes 0.000 claims description 17
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 14
- 229920000831 ionic polymer Polymers 0.000 claims description 12
- 108091034117 Oligonucleotide Proteins 0.000 claims description 10
- 150000001875 compounds Chemical class 0.000 claims description 9
- 239000003446 ligand Chemical group 0.000 claims description 8
- 108091033319 polynucleotide Proteins 0.000 claims description 8
- 239000002157 polynucleotide Substances 0.000 claims description 8
- 102000040430 polynucleotide Human genes 0.000 claims description 8
- 125000005647 linker group Chemical group 0.000 claims description 7
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical group C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 5
- 125000000524 functional group Chemical group 0.000 claims description 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 5
- 239000000693 micelle Substances 0.000 claims description 5
- 229910019142 PO4 Inorganic materials 0.000 claims description 4
- 125000000217 alkyl group Chemical group 0.000 claims description 4
- 239000010452 phosphate Substances 0.000 claims description 4
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 claims description 3
- 239000012736 aqueous medium Substances 0.000 claims description 3
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 3
- -1 carbonyliminophenyl Chemical group 0.000 claims description 3
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims description 2
- 125000003277 amino group Chemical group 0.000 claims description 2
- 150000001450 anions Chemical class 0.000 claims description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 4
- 229920000768 polyamine Polymers 0.000 claims 4
- 230000000295 complement effect Effects 0.000 claims 3
- HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 claims 2
- 108010039918 Polylysine Proteins 0.000 claims 2
- 108091028664 Ribonucleotide Proteins 0.000 claims 2
- PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 claims 2
- 108020004459 Small interfering RNA Proteins 0.000 claims 2
- 150000001241 acetals Chemical class 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 claims 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- 230000004962 physiological condition Effects 0.000 claims 2
- 229920000656 polylysine Polymers 0.000 claims 2
- 239000002336 ribonucleotide Substances 0.000 claims 2
- 125000002652 ribonucleotide group Chemical group 0.000 claims 2
- 125000004434 sulfur atom Chemical group 0.000 claims 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims 1
- 241000737052 Naso hexacanthus Species 0.000 claims 1
- 229920002873 Polyethylenimine Polymers 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 239000005547 deoxyribonucleotide Substances 0.000 claims 1
- 125000002637 deoxyribonucleotide group Chemical group 0.000 claims 1
- 239000008101 lactose Substances 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 108010011110 polyarginine Proteins 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 210000004102 animal cell Anatomy 0.000 description 3
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 2
- 238000010348 incorporation Methods 0.000 description 2
- 239000002953 phosphate buffered saline Substances 0.000 description 2
- 125000002777 acetyl group Chemical class [H]C([H])([H])C(*)=O 0.000 description 1
- 230000000739 chaotic effect Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004254824A JP2006067889A (ja) | 2004-09-01 | 2004-09-01 | Ｐｅｏと二本鎖核酸のコンジュゲート |
| EP05781466A EP1801210A4 (en) | 2004-09-01 | 2005-08-24 | CONJUGATED PEO AND NUCLEIC ACID DOUBLE STRAND |
| PCT/JP2005/015831 WO2006025419A1 (ja) | 2004-09-01 | 2005-08-24 | Ｐｅｏと二本鎖核酸のコンジュゲート |
| US11/661,810 US20080064863A1 (en) | 2004-09-01 | 2005-08-24 | Conjugate of Peo and Double Stranded Nucleic Acid |
| KR1020077004747A KR100865062B1 (ko) | 2004-09-01 | 2005-08-24 | Ｐｅｏ 와 2 개 사슬 핵산의 콘쥬게이트 |
| CA002578616A CA2578616A1 (en) | 2004-09-01 | 2005-08-24 | Conjugate of peo with double-stranded nucleic acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004254824A JP2006067889A (ja) | 2004-09-01 | 2004-09-01 | Ｐｅｏと二本鎖核酸のコンジュゲート |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006067889A JP2006067889A (ja) | 2006-03-16 |
| JP2006067889A5 true JP2006067889A5 (OSRAM) | 2007-07-12 |
Family
ID=36000069
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004254824A Pending JP2006067889A (ja) | 2004-09-01 | 2004-09-01 | Ｐｅｏと二本鎖核酸のコンジュゲート |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20080064863A1 (OSRAM) |
| EP (1) | EP1801210A4 (OSRAM) |
| JP (1) | JP2006067889A (OSRAM) |
| KR (1) | KR100865062B1 (OSRAM) |
| CA (1) | CA2578616A1 (OSRAM) |
| WO (1) | WO2006025419A1 (OSRAM) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003219576A1 (en) | 2003-04-03 | 2004-10-25 | Korea Advanced Institute Of Science And Technology | Conjugate for gene transfer comprising oligonucleotide and hydrophilic polymer, polyelectrolyte complex micelles formed from the conjugate, and methods for preparation thereof |
| US8969543B2 (en) | 2003-04-03 | 2015-03-03 | Bioneer Corporation | SiRNA-hydrophilic polymer conjugates for intracellular delivery of siRNA and method thereof |
| US8092788B2 (en) * | 2004-03-03 | 2012-01-10 | Revance Therapeutics, Inc. | Compositions and methods for topical diagnostic and therapeutic transport |
| US9211248B2 (en) | 2004-03-03 | 2015-12-15 | Revance Therapeutics, Inc. | Compositions and methods for topical application and transdermal delivery of botulinum toxins |
| WO2005100447A1 (ja) | 2004-04-16 | 2005-10-27 | Japan Science And Technology Agency | Ｐｅｇ−機能性核酸コンジュケート |
| SG160357A1 (en) | 2005-03-03 | 2010-04-29 | Revance Therapeutics Inc | Compositions and methods for topical application and transdermal delivery of botulinum toxins |
| AU2006280600B2 (en) * | 2005-08-17 | 2012-01-19 | Bioneer Corporation | Sirna-hydrophilic polymer conjugates for intracellular delivery of siRNA and method thereof |
| US20080311040A1 (en) * | 2007-03-06 | 2008-12-18 | Flagship Ventures | METHODS AND COMPOSITIONS FOR IMPROVED THERAPEUTIC EFFECTS WITH siRNA |
| EP2306986B1 (en) | 2008-06-26 | 2018-03-21 | Prolynx Llc | Prodrugs and drug-macromolecule conjugates having controlled drug release rates |
| WO2010021720A1 (en) * | 2008-08-19 | 2010-02-25 | Nektar Therapeutics | Conjugates of small-interfering nucleic acids |
| WO2010110455A1 (ja) | 2009-03-27 | 2010-09-30 | 国立大学法人 鹿児島大学 | 疎水化ポリアミノ酸からなるポリイオンコンプレックスとその用途 |
| CN102250348B (zh) * | 2011-05-31 | 2013-02-20 | 安徽丰原淮海制药有限公司 | 一种聚乙烯亚胺衍生物及其作为基因传递的载体 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4659937B2 (ja) * | 1999-11-19 | 2011-03-30 | ナノキャリア株式会社 | コア−シェル構造のポリイオンコンプレックスミセル |
| US7094605B2 (en) * | 2001-01-02 | 2006-08-22 | Mirus Bio Corporation | Formation of polyampholytes in the presence of a polyion |
| US20040162235A1 (en) * | 2003-02-18 | 2004-08-19 | Trubetskoy Vladimir S. | Delivery of siRNA to cells using polyampholytes |
| JP4109559B2 (ja) * | 2003-02-19 | 2008-07-02 | 独立行政法人科学技術振興機構 | オリゴヌクレオチドとポリエチレンオキシドのコンジュゲート |
-
2004
- 2004-09-01 JP JP2004254824A patent/JP2006067889A/ja active Pending
-
2005
- 2005-08-24 WO PCT/JP2005/015831 patent/WO2006025419A1/ja not_active Ceased
- 2005-08-24 US US11/661,810 patent/US20080064863A1/en not_active Abandoned
- 2005-08-24 CA CA002578616A patent/CA2578616A1/en not_active Abandoned
- 2005-08-24 EP EP05781466A patent/EP1801210A4/en not_active Ceased
- 2005-08-24 KR KR1020077004747A patent/KR100865062B1/ko not_active Expired - Fee Related
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