JP2006045237A5 - - Google Patents

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Publication number
JP2006045237A5
JP2006045237A5 JP2005228930A JP2005228930A JP2006045237A5 JP 2006045237 A5 JP2006045237 A5 JP 2006045237A5 JP 2005228930 A JP2005228930 A JP 2005228930A JP 2005228930 A JP2005228930 A JP 2005228930A JP 2006045237 A5 JP2006045237 A5 JP 2006045237A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2005228930A
Other languages
Japanese (ja)
Other versions
JP2006045237A (ja
Filing date
Publication date
Application filed filed Critical
Publication of JP2006045237A publication Critical patent/JP2006045237A/ja
Publication of JP2006045237A5 publication Critical patent/JP2006045237A5/ja
Withdrawn legal-status Critical Current

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JP2005228930A 1994-01-25 2005-08-05 白血球付着分子vla−4に対するヒト化抗体 Withdrawn JP2006045237A (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US18626994A 1994-01-25 1994-01-25

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP51977095A Division JP4115517B2 (ja) 1994-01-25 1995-01-25 白血球付着分子 vla−4に対するヒト化抗体

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2009120421A Division JP2009235078A (ja) 1994-01-25 2009-05-18 白血球付着分子vla−4に対するヒト化抗体

Publications (2)

Publication Number Publication Date
JP2006045237A JP2006045237A (ja) 2006-02-16
JP2006045237A5 true JP2006045237A5 (enExample) 2006-06-22

Family

ID=22684288

Family Applications (5)

Application Number Title Priority Date Filing Date
JP51977095A Expired - Lifetime JP4115517B2 (ja) 1994-01-25 1995-01-25 白血球付着分子 vla−4に対するヒト化抗体
JP2005228930A Withdrawn JP2006045237A (ja) 1994-01-25 2005-08-05 白血球付着分子vla−4に対するヒト化抗体
JP2009120421A Withdrawn JP2009235078A (ja) 1994-01-25 2009-05-18 白血球付着分子vla−4に対するヒト化抗体
JP2013028635A Expired - Lifetime JP5487382B2 (ja) 1994-01-25 2013-02-18 白血球付着分子vla−4に対するヒト化抗体
JP2013054628A Withdrawn JP2013165718A (ja) 1994-01-25 2013-03-18 白血球付着分子vla−4に対するヒト化抗体

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP51977095A Expired - Lifetime JP4115517B2 (ja) 1994-01-25 1995-01-25 白血球付着分子 vla−4に対するヒト化抗体

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2009120421A Withdrawn JP2009235078A (ja) 1994-01-25 2009-05-18 白血球付着分子vla−4に対するヒト化抗体
JP2013028635A Expired - Lifetime JP5487382B2 (ja) 1994-01-25 2013-02-18 白血球付着分子vla−4に対するヒト化抗体
JP2013054628A Withdrawn JP2013165718A (ja) 1994-01-25 2013-03-18 白血球付着分子vla−4に対するヒト化抗体

Country Status (21)

Country Link
EP (2) EP0804237B8 (enExample)
JP (5) JP4115517B2 (enExample)
KR (1) KR100367948B1 (enExample)
CN (1) CN1211123C (enExample)
AT (1) ATE333895T1 (enExample)
AU (1) AU703152B2 (enExample)
CA (1) CA2182013C (enExample)
DE (2) DE122006000043I1 (enExample)
DK (2) DK0804237T3 (enExample)
ES (2) ES2424292T3 (enExample)
FI (1) FI117509B (enExample)
FR (1) FR06C0024I2 (enExample)
HU (1) HU220799B1 (enExample)
LU (1) LU91271I2 (enExample)
MX (1) MX9602971A (enExample)
NL (1) NL300238I2 (enExample)
NO (3) NO319867B1 (enExample)
NZ (1) NZ279730A (enExample)
PL (1) PL181827B1 (enExample)
PT (1) PT804237E (enExample)
WO (1) WO1995019790A1 (enExample)

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AU688751B2 (en) 1993-01-12 1998-03-19 Biogen Idec Ma Inc. Recombinant anti-VLA4 antibody molecules
JP3593343B2 (ja) * 1993-02-09 2004-11-24 バイオジェン インコーポレイテッド インシュリン依存型糖尿病の治療
US5840299A (en) * 1994-01-25 1998-11-24 Athena Neurosciences, Inc. Humanized antibodies against leukocyte adhesion molecule VLA-4
US7435802B2 (en) 1994-01-25 2008-10-14 Elan Pharaceuticals, Inc. Humanized anti-VLA4 immunoglobulins
US7750137B2 (en) 1995-09-01 2010-07-06 Millennium Pharmaceuticals, Inc. Mucosal vascular addressins
US6551593B1 (en) 1995-02-10 2003-04-22 Millennium Pharmaceuticals, Inc. Treatment of Inflammatory bowel disease by inhibiting binding and/or signalling through α 4 β 7 and its ligands and madcam
US7803904B2 (en) 1995-09-01 2010-09-28 Millennium Pharmaceuticals, Inc. Mucosal vascular addressing and uses thereof
US7147851B1 (en) * 1996-08-15 2006-12-12 Millennium Pharmaceuticals, Inc. Humanized immunoglobulin reactive with α4β7 integrin
WO1998051345A2 (en) * 1997-05-09 1998-11-19 The John P. Robarts Research Institute Method for dislodging infiltrated leukocytes from a tissue
DE19741235A1 (de) 1997-09-18 1999-03-25 Hoechst Marion Roussel De Gmbh Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19741873A1 (de) * 1997-09-23 1999-03-25 Hoechst Marion Roussel De Gmbh Neue 5-Ring-Heterocyclen, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19751251A1 (de) 1997-11-19 1999-05-20 Hoechst Marion Roussel De Gmbh Substituierte Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmezeutische Präparate
DE19821483A1 (de) 1998-05-14 1999-11-18 Hoechst Marion Roussel De Gmbh Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
WO2000015247A2 (en) * 1998-09-14 2000-03-23 Board Of Regents, The University Of Texas System Methods of treating multiple myeloma and myeloma-induced bone resorption using integrin antagonists
US7618630B2 (en) 1998-09-14 2009-11-17 Board Of Regents, The University Of Texas System Methods of treating multiple myeloma and myeloma-induced bone resorption using integrin antagonists
IL145898A0 (en) * 1999-04-22 2002-07-25 Biogen Inc Method for the treatment of fibrosis using an antagonist of the integrin alpha-4 subunit
DE19922462A1 (de) 1999-05-17 2000-11-23 Aventis Pharma Gmbh Spiro-imidazolidinderivate, ihre Herstellung ihre Verwendung und sie enthaltende pharmazeutische Präparate
EE200100651A (et) 1999-06-01 2003-02-17 Biogen, Inc. VLA-1 blokeeriv monoklonaalne antikeha ja tema kasutamine põletiku raviks
US6949245B1 (en) 1999-06-25 2005-09-27 Genentech, Inc. Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies
DK2140881T3 (da) * 1999-12-16 2013-05-06 Biogen Idec Inc Fremgangsmåder til behandling af iskæmisk eller hæmoragisk læsion i centralnervesystemet ved anvendelse af anti-alpha-4-integrin-antagonister
DE10111877A1 (de) 2001-03-10 2002-09-12 Aventis Pharma Gmbh Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
NZ529494A (en) 2001-04-13 2005-08-26 Biogen Idec Inc Antibodies to VLA-1
DE10137595A1 (de) 2001-08-01 2003-02-13 Aventis Pharma Gmbh Neue Imidazolidinderivate, ihre Herstellung und ihre Verwendung
NZ535320A (en) 2002-02-25 2008-05-30 Elan Pharm Inc Administration of agents that bind to an alpha-4 integrin for the treatment of inflammation
CA2481747A1 (en) * 2002-04-12 2003-10-23 Medimmune, Inc. Recombinant anti-interleukin-9 antibodies
GB0210121D0 (en) * 2002-05-02 2002-06-12 Celltech R&D Ltd Biological products
AR040778A1 (es) * 2002-08-06 2005-04-20 Glaxo Group Ltd Anticuerpos alterados o fragmentos funcionales que se unen a mag (glicoproteina asociada a mielina).
AU2003298187B2 (en) * 2002-12-17 2010-09-16 Merck Patent Gmbh Humanized antibody (H14.18) of the mouse 14.18 antibody binding to GD2 and its fusion with IL-2
CU23403A1 (es) * 2003-04-23 2009-08-04 Centro Inmunologia Molecular Anticuerpos recombinantes y fragmentos que reconocen el gangliósido n-glicolil gm3 y su uso para diagnóstico y tratamiento de tumores
WO2005061466A1 (ja) 2003-12-22 2005-07-07 Ajinomoto Co., Inc. 新規フェニルアラニン誘導体
CN103169965A (zh) * 2004-11-19 2013-06-26 比奥根艾迪克Ma公司 治疗多发性硬化
WO2007061679A1 (en) * 2005-11-17 2007-05-31 Millennium Pharmaceuticals, Inc. HUMANIZED IMMUNOGLOBULIN REACTIVE WITH α4β7 INTEGRIN
CN105381459A (zh) 2006-05-25 2016-03-09 比奥根Ma公司 治疗中风的方法
EP2510941A3 (en) 2007-02-20 2013-01-23 Merrimack Pharmaceuticals, Inc. Methods of treating multiple sclerosis by administration of alpha-fetoprotein in combination with an integrin antagonist
US20080311119A1 (en) * 2007-06-14 2008-12-18 Biogen Idec Ma Inc. Antibody formulations
BRPI0820202B1 (pt) 2007-12-13 2018-05-08 Tokuyama Corp composição curável fotocrômica
ES2525065T3 (es) 2008-04-11 2014-12-17 Merrimack Pharmaceuticals, Inc. Ligadores de seroalbúmina humana y sus conjugados
MY162752A (en) 2009-03-20 2017-07-14 Amgen Inc Alpha-4-beta-7 heterodimer specific antagonist antibody
US20120258093A1 (en) 2009-08-20 2012-10-11 Institut National De La Sante Et De La Recherche Medicale (Inserm) Vla-4 as a biomarker for prognosis and target for therapy in duchenne muscular dystrophy
ME02793B (me) 2010-04-16 2018-01-20 Biogen Ma Inc Anti-vla-4 antitijela
CA2834900C (en) 2011-05-02 2021-03-02 Millennium Pharmaceuticals, Inc. Formulation for anti-.alpha.4.beta.7 antibody
UA116189C2 (uk) 2011-05-02 2018-02-26 Мілленніум Фармасьютікалз, Інк. КОМПОЗИЦІЯ АНТИ-α4β7 АНТИТІЛА
MX370199B (es) 2012-02-16 2019-12-05 Santarus Inc Composiciones farmaceuticas de anticuerpo anti-antigeno muy tardio (cd49a).
US20190225694A1 (en) 2016-06-28 2019-07-25 Zaklady Farmaceutyczne Polpharma Sa Recombinant production of monoclonal antibodies
US20190374639A1 (en) 2016-11-21 2019-12-12 Polpharma Biologics S.A. Aqueous pharmaceutical formulations
EP3583126B1 (en) * 2017-02-17 2025-08-27 Sanofi Multispecific binding molecules having specificity to dystroglycan and laminin-2
WO2018224673A1 (en) 2017-06-08 2018-12-13 Zaklady Farmaceutyczne Polpharma S.A. Improved methods of cell culture
EP3800999A4 (en) 2018-06-04 2022-06-01 Biogen MA Inc. ANTI-VLA-4 ANTIBODY WITH REDUCED EFFECTIVE FUNCTION
WO2022162164A1 (en) 2021-01-29 2022-08-04 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of assessing the risk of developing progressive multifocal leukoencephalopathy in patients treated with vla-4 antagonists

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US5225539A (en) * 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
IL162181A (en) * 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
IL113261A (en) * 1989-09-01 1996-10-16 Hutchinson Fred Cancer Res Inhibition by peptides of lymphocyte adherence to vascular endothelium utilizing an extracellular matrix receptor-ligand interaction and pharmaceutical compositions containing said peptides
DK0625912T3 (da) * 1992-02-12 1997-10-27 Biogen Inc Behandling af inflammatorisk tarmsygdom
AU688751B2 (en) * 1993-01-12 1998-03-19 Biogen Idec Ma Inc. Recombinant anti-VLA4 antibody molecules
AUPP647298A0 (en) 1998-10-13 1998-11-05 Keystone Retaining Wall Systems, Inc. Retaining wall block

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