JP2006045063A - Whitening cosmetic - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To prepare a whitening cosmetic which is excellent in stability of the cosmetic, exerts a sufficient whitening effect and causes little irritation. <P>SOLUTION: This whitening cosmetic contains a compound having a plurality of chains and a plurality of hydrophilic groups, which has two or more long-chain hydrophilic groups and two or more hydrophilic groups within the molecule. <P>COPYRIGHT: (C)2006,JPO&amp;NCIPI

Description

  The present invention relates to a whitening cosmetic comprising a multi-chain polyhydrophilic group type compound.

Conventionally, arbutin, kojic acid, ellagic acid, ascorbic acid, placenta extract, and derivatives thereof have been blended in whitening cosmetics. However, since these components do not have surface activity, it is difficult to stably mix them in cosmetics such as lotions, emulsions, and creams. For example, water-soluble ascorbic acid derivatives cause precipitation in cosmetics, There were problems such as breaking the emulsion and causing creaming. As a countermeasure, for example, Japanese Patent Laid-Open No. 63-243014 discloses a technique of adding a nonionic surfactant and an electrolyte in order to stably blend in cosmetics, but the whitening effect is not sufficient. .
Further, as a surfactant having a whitening effect, there is a 2-aminoethanesulfin derivative (Japanese Patent Laid-Open No. 6-329621), but it is highly irritating to the skin and ocular mucosa and is not satisfactory in terms of safety. . Thus, whitening cosmetics that are excellent in cosmetic stability, exhibit a sufficient whitening effect, and have little irritation have been eagerly desired.
Japanese Unexamined Patent Publication No. 63-243014 Japanese Patent Laid-Open No. 6-329621

  An object of the present invention is to provide a whitening cosmetic that is excellent in the stability of cosmetics, exhibits a sufficient whitening effect, and has little irritation.

As a result of intensive studies to solve the above problems, the present inventors have determined that a specific compound, that is, a compound having two or more long-chain hydrophobic groups and hydrophilic groups in the molecule (multi-chain multi-hydrophilic group type). Compounding this with a whitening component, it has been found that it has excellent cosmetic stability, a sufficient whitening effect and a less irritating whitening cosmetic. It came to do.
That is, the present invention is as follows.
1. Whitening cosmetics characterized by containing the following component (A).
Component (A): One or more of a multi-chain polyhydrophilic group-type surfactant having two or more long-chain hydrophobic groups and hydrophilic groups in the molecule.
2. At least one of the multi-chain polyhydrophilic group-type surfactant has a long-chain hydrophobic group as a long-chain acyl group, and a hydrophilic group as a carboxyl group, sulfonic acid group, sulfate ester group, phosphate ester group and salts thereof 1. An anionic surfactant that is at least one selected from 1. Whitening cosmetics described in 1.
3. 1. At least one kind of a multi-chain polyhydrophilic group-type surfactant has an amino acid residue in the molecule. Or 2. Whitening cosmetics described in 1.
4). 1. At least one of the multi-chain polyhydrophilic group-type surfactant is a compound represented by the general formula (1). ~ 3. The whitening cosmetic according to any one of the above.

(In the general formula (1), X is a linear, branched, cyclic or aromatic hydrocarbon chain having a molecular weight of 1 million or less, which may have m functional groups and other substituents. 1 represents a spacer, and n (m ≧ n) Q bonded to X are substituents represented by the general formula (2), and may be the same as or different from each other. ), Z is a bond derived from a functional group of X, R ¹ CO represents a long-chain acyl group derived from a saturated or unsaturated fatty acid having 8 to 20 carbon atoms, and R ² represents hydrogen Or a lower alkyl group having 1 to 3 carbon atoms which may be substituted by a hydroxyl group or a carboxyl group, and Y represents a carboxyl group, a sulfonic acid group, a sulfate ester group, a phosphate ester group or a group thereof. One of the salt J and k are each independently 0, 1, or 2, and j and k are not simultaneously 0. n represents an integer of 2 to 20. m is an integer satisfying m ≧ n. Is shown.)

5. At least one of the multi-chain polyhydrophilic group-type surfactant is a compound represented by the general formula (1), and in the general formula (1), X may have a substituent other than the functional group. 1. A spacer which is a linear, branched, cyclic, or aromatic hydrocarbon chain of 1 to 40. ~ 4. The whitening cosmetic according to any one of the above.
6). Furthermore, it contains at least one component (B): whitening component. ~ 5. The whitening cosmetic according to any one of the above.
7). Furthermore, it contains at least one selected from component (C): anionic surfactant, amphoteric surfactant, and cationic surfactant. ~ 6. The whitening cosmetic according to any one of the above.
8). Furthermore, it contains at least one component (D): polyhydroxyl compound. ~ 7. The whitening cosmetic according to any one of the above.
9. 1 above. ~ 8. A whitening method characterized by using the whitening cosmetic composition described in any of the above.

  According to the present invention, it is possible to provide a whitening cosmetic composition that is excellent in cosmetic stability, exhibits a sufficient whitening effect, and has little irritation.

Hereinafter, the present invention will be specifically described.
The whitening cosmetic composition of the present invention is structurally a composition comprising at least one multi-chain polyhydrophilic group type compound having two or more long-chain hydrophobic groups and hydrophilic groups in the molecule. Any structure may be used as long as it has a structure.
In the whitening cosmetic composition of the present invention, as the multi-chain polyhydrophilic group-type compound, each of the long-chain hydrophobic groups is independently a saturated or unsaturated linear, branched, or cyclic chain having 8 to 20 carbon atoms. Each of the hydrophilic groups independently includes a carboxyl group, a sulfonic acid group, a sulfuric acid residue, a phosphoric acid residue or a salt thereof, an oxyalkylene group, a polyethylene glycol group, or the like, or an amino group, It has a quaternary ammonium group, a pyridinium group, a sulfonium group or a salt thereof.

For example, as the long-chain hydrophobic group of the multi-chain polyhydrophilic group compound, for example, n-octyl, n-nonyl, n-decyl, n-undecyl, n-dodecyl, n-tridecyl, n-tetradecyl, n-pentadecyl, Residues such as n-hexadecyl, n-heptadecyl, n-octadecyl, n-nonadecyl, n-eicosyl, etc. and branched isomers thereof, and corresponding one, two or three unsaturated sites And an unsaturated residue having a moiety.
The long-chain hydrophobic group of the multi-chain polyhydrophilic group-type compound is a long-chain acyl group derived from a saturated or unsaturated fatty acid having 8 to 20 carbon atoms, and each acyl group is independently selected. That is, they may be different or the same.

For example, linear fatty acids such as caprylic acid, pelargonic acid, capric acid, undecanoic acid, lauric acid, tridecanoic acid, myristic acid, pentadecanoic acid, palmitic acid, margaric acid, stearic acid, nonadecanoic acid, arachidic acid;
2-butyl-5-methylpentanoic acid, 2-isobutyl-5-methylpentanoic acid, dimethyloctanoic acid, dimethylnonanoic acid, 2-butyl-5-methylhexanoic acid, methylundecanoic acid, dimethyldecanoic acid, 2-ethyl- 3-methylnonanoic acid, 2,2-dimethyl-4-ethyloctanoic acid, methyldocosanoic acid, 2-propyl-3-methylnonanoic acid, methyltridecanoic acid, dimethyldodecanoic acid, 2-butyl-3-methylnonanoic acid, methyltetradecanoic acid , Ethyltridecanoic acid, propyldodecanoic acid, butylundecanoic acid, pentyldecanoic acid, hexylnonanoic acid, 2- (3-methylbutyl) -3-methylnonanoic acid, 2- (2-methylbutyl) -3-methylnonanoic acid, butylethylnonane Acid, methylpentadecanoic acid, ethyltetradecanoic acid, propyltri Canic acid, butyldodecanoic acid, pentylundecanoic acid, hexyldecanoic acid, heptylnonanoic acid, dimethyltetradecanoic acid, butylpentylheptanoic acid, trimethyltridecanoic acid, methylhexadecanoic acid, ethylpentadecanoic acid, propyltetradecanoic acid, butyltridecanoic acid, pentyldodecane Acid, hexylundecanoic acid, heptyldecanoic acid, methylheptylnonanoic acid, dipentylheptanoic acid, methylheptadecanoic acid, ethylhexadecanoic acid, ethylhexadecanoic acid, propylpentadecanoic acid, butyltetradecanoic acid, pentyltridecanoic acid, hexyldodecanoic acid, heptyl Undecanoic acid, octyldecanoic acid, dimethylhexadecanoic acid, methyloctylnonanoic acid, methyloctadecanoic acid, ethylheptadecanoic acid, dimethylheptadecanoic acid, Octyl decanoic acid, Mechirunonadekan acid, Mechirunonadekan acid, dimethyl octadecanoic acid, branched fatty acids such as butyl heptyl nonanoic acid;

Octenoic acid, nonenoic acid, decenoic acid, caproleic acid, undecylenic acid, Lindelic acid, touric acid, lauroleic acid, tridecenoic acid, tuzuic acid, myristoleic acid, pentadecenoic acid, hexedenoic acid, palmitoleic acid, heptadecenoic acid, octadecenoic acid, Linear monoenoic acids such as oleic acid, nonadecenoic acid, gondoic acid;
Such as methylheptenoic acid, methylnonenoic acid, methylundecenoic acid, dimethyldecenoic acid, methyldodecenoic acid, methyltridecenoic acid, dimethyldodecenoic acid, dimethyltridecenoic acid, methyloctadecenoic acid, dimethylheptadecenoic acid, ethyloctadecenoic acid Branched monoenoic acid;
Di- or trienoic acids such as linoleic acid, linoleic acid, eleostearic acid, linolenic acid, linolenic elaidic acid, pseudoeleostearic acid, parinaric acid, arachidonic acid;
Acetylene acids such as octinoic acid, nonic acid, decinic acid, undecinic acid, dodecinic acid, tridecinic acid, tetradecinic acid, pentadecinic acid, heptadesinic acid, octadecinic acid, nonadesinic acid, dimethyloctadesinic acid;
Of methyleneoctadecenoic acid, methyleneoctadecanoic acid, aleprolic acid, alepresinic acid, allepuric acid, alepuric acid, hydnocarpic acid, shoulmuccinic acid, gorulic acid, α-cyclopentylic acid, α-cyclohexylic acid, α-cyclopentylethylic acid And acyl groups derived from such cyclic acids.

Moreover, the acyl group derived from the fatty acid obtained from natural fats and oils may be sufficient, and the acyl group derived from the mixed fatty acid containing 80% or more of the above saturated or unsaturated fatty acid having 8 to 20 carbon atoms is preferable. For example, acyl groups derived from coconut oil fatty acid, palm oil fatty acid, linseed oil fatty acid, sunflower oil fatty acid, soybean oil fatty acid, sesame oil fatty acid, castor oil fatty acid, olive oil fatty acid, camellia oil fatty acid, rapeseed oil fatty acid, palm kernel oil fatty acid, etc. Etc. Two or more of these acyl compounds may be used in combination.
When a polychain polyhydrophilic group type compound is used as a salt, examples thereof include alkali metal salts, alkaline earth metal salts, ammonium salts, organic amine salts, basic amino acid salts, and the like. Specifically, sodium, potassium Alkaline metals such as lithium, alkaline earth metals such as calcium and magnesium, metals such as aluminum and zinc, organic amines such as ammonia, monoethanolamine, diethanolamine, triethanolamine and triisopropanolamine, bases such as arginine and lysine Or a salt with one or more selected from amino acids and the like. Among these, sodium salts, potassium salts, organic amine salts, and basic amino acid salts are particularly preferable.

In the present invention, it is preferable that at least one of the multi-chain polyhydrophilic group type compounds contained in the whitening cosmetic is an acyl compound represented by the general formulas (1) and (2).
The acyl compound here has a structure in which a compound having at least one acyl group and a hydrophilic group in the molecule is linked by an appropriate spacer as shown in the general formulas (1) and (2). Is.
In the general formula (2), the acyl group represented by R ¹ CO may be independently, that is, may be different or the same, and is derived from a saturated or unsaturated fatty acid having 8 to 20 carbon atoms as described above. Any material can be used as long as it is linear, branched or cyclic.

In general formula (2), R ² is hydrogen, or the number of carbon atoms that may be substituted by a hydroxyl group or a carboxyl group, a sulfonic acid group, a sulfuric ester group, a phosphoric ester group, or a salt thereof. To 3 lower alkyl groups such as methyl, ethyl, propyl, isopropyl, hydroxymethyl, hydroxyethyl, hydroxy (iso) propyl, dihydroxy (iso) propyl, carboxymethyl, carboxy Examples include an ethyl group, a carboxypropyl group, and a sulfoethyl group.
In the general formula (1), n substituents Q (formula (2)) bonded to X may be different from each other or the same. Moreover, Formula (2) shows what is called an acidic amino acid N-acylated, and it does not ask | require whether they are optical isomers, for example, D-form, L-form, and a racemate.

  The acidic amino acid is a monoaminodicarboxylic acid having 2 and 1 carboxyl groups and 1 amino group, respectively, in the molecule, and the amino group may be an N-methyl group or an N-ethyl group. It does not matter whether it is an optical isomer, for example, a D-form, an L-form, or a racemate. Examples of acidic amino acids include glutamic acid, aspartic acid, lanthionine, β-methyllanthionine, cystathionine, diencholic acid, ferrinin, aminomalonic acid, β-oxyaspartic acid, α-amino-α-methylsuccinic acid, β-oxyglutamic acid. , Γ-oxyglutamic acid, γ-methylglutamic acid, γ-methyleneglutamic acid, γ-methyl-γ-oxyglutamic acid, α-aminoadipic acid, α-amino-γ-oxyadipic acid, α-aminopimelic acid, α-amino- Examples thereof include γ-oxypimelic acid, β-aminopimelic acid, α-aminosuberic acid, α-aminosebacic acid, pantothenic acid and the like.

The n substituents (formula (2)) attached to X are preferable because the acidic amino acid is an L-acidic amino acid molecule because it is excellent in biodegradability.
In the general formula (2), Z is a bonding part (—O) derived from m functional groups (hydroxyl group, amino group, thiol group) substituted with X (m ≧ n and an integer of 2 to 20). -, -NR < ³ >-, -S-). Here, R ³ is hydrogen, or an alkyl group, alkenyl group, aryl group or alkylaryl group having 1 to 10 carbon atoms.
In general formula (1), X is a linear or branched or cyclic chain having a molecular weight of 1 million or less and having m functional groups consisting of one or more selected from a hydroxyl group, an amino group and a thiol group. It is a spacer which is an aromatic hydrocarbon chain, and X may have a substituent other than the hydroxyl group, amino group and thiol group.

In the general formula (1), X is preferably a residue of an m-valent compound having a molecular weight of 1 million or less and having m functional groups of one kind or two or more kinds selected from a hydroxyl group, an amino group and a thiol group. , A compound residue that may have a substituent other than a hydroxyl group, an amino group, or a thiol group. Here, the m-valent compound means that a bond derived from m functional groups can be formed. It does not matter whether they are optical isomers such as D-form, L-form, and racemate.
Examples of such m-valent compounds include amino acids such as serine, threonine, cysteine, cystine, cystine disulfoxide, cystathionine, methionine, arginine, lysine, tyrosine, histidine, tryptophan, and oxyproline;
Aminoethanol, aminopropanol, aminobutanol, aminopentanol, aminohexanol, aminopropanediol, aminoethylethanolamine, aminoethylaminoethanol, aminocresol, aminonaphthol, aminonaphtholsulfonic acid, aminohydroxybenzoic acid, aminohydroxybutanoic acid Compounds having an amino group and a hydroxyl group in the molecule such as aminophenol, aminophenethyl alcohol, glucosamine;
Compounds having a thiol group and a hydroxyl group in the molecule such as mercaptoethanol, mercaptophenol, mercaptopropanediol, glucothiose;
Compounds having a thiol group and an amino group in the molecule such as aminothiophenol and aminotriazole thiol;
Is mentioned. Further, proteins, peptides, etc., or those obtained by hydrolyzing them may be used.

In the general formula (1), X is preferably an m-valent (m ≧ n) polyhydroxyl compound residue having a molecular weight of 1,000,000 or less, which may have a substituent other than a hydroxyl group. Here, the m-valent polyhydroxyl compound means that m ester bonds can be formed. It does not matter whether they are optical isomers such as D-form, L-form, and racemate.
Examples of such m-valent polyhydroxyl compounds include ethylene glycol, 1,2-propanediol, 1,3-propanediol, 1,2-butanediol, 1,3-butanediol, and 1,4-butanediol. , Pentanediol, 1,6-hexanediol, cyclohexanediol, dimethylolcyclohexane, neopentyl glycol, 1,8-octanediol,
2,2,4-trimethyl-1,3-pentanediol, isoprene glycol, 3-methyl-1,5-pentanediol, sorbite, catechol, resorcin, hydroquinone, bisphenol A, bisphenol F, hydrogenated bisphenol A, hydrogenated Bisphenol F,

Dimerdiol, dimethylolpropionic acid, dimethylolbutanoic acid, tartaric acid, dihydroxytartaric acid, mevalonic acid, 3,4-dihydroxycinnamic acid, 3,4-dihydroxyhydrocinnamic acid, hydroxybenzoic acid, dihydroxystearic acid, dihydroxyphenylalanine And divalent hydroxyl compounds such as each of these isomers;
Glycerin, trioxyisobutane, 1,2,3-butanetriol, 1,2,3-pentanetriol, 2-methyl-1,2,3-propanetriol, 2-methyl-2,3,4-butanetriol, 2-ethyl-1,2,3-butanetriol, 2,3,4-pentanetriol,
2,3,4-hexanetriol, 4-propyl-3,4,5-heptanetriol, 2,4-dimethyl-2,3,4-pentanetriol, 1,2,4-butanetriol, 1,2, Trivalent polyhydroxyl compounds such as 4-pentanetriol, trimethylolethane, trimethylolpropane, diethanolamine, triethanolamine, trihydroxystearic acid;
Pentaerythritol, erythritol, 1,2,3,4-pentanetetrol, 2,3,4,5-hexanetetrol, 1,2,4,5-pentanetetrol, 1,3,4,5-hexane Tetravalent polyhydroxyl compounds such as tetrol, diglycerin and sorbitan;
Pentavalent polyhydroxyl compounds such as adonitol, arabitol, xylitol, triglycerin;
Hexavalent polyhydroxyl compounds such as dipentaerythritol, sorbitol, mannitol, iditol, inositol, dulcitol, talose, allose;
Or these dehydration condensates, polyglycerol, etc. are mentioned.

Sugars such as tetroses such as erythrose, sreose, erythrulose;
Pentose such as ribose, arabinose, xylose, lyxose, xylulose, ribulose; monosaccharides such as hexose such as allose, altrose, glucose, mannose, guylose, idose, galactose, talose, fructose, sorbose, psicose, tagatose;
Examples thereof include oligosaccharides such as maltose, isomaltose, cellobiose, gentiobiose, melibiose, lactose, tulanose, trehalose, saccharose, mannitolose, cellotriose, gentianose, raffinose, meletitose, cellotetorose, stachyose and the like.

In addition, other saccharides such as heptose, deoxy sugar, amino sugar, thio sugar, seleno sugar, aldone sugar, uronic acid, sugar acid, ketoaldonic acid, anhydro sugar, unsaturated sugar, sugar ester, sugar ether, glycoside, etc. It may be a group, and may be a polysaccharide such as starch, glycogen, cellulose, chitin, chitosan or the like, or a hydrolyzed product thereof.
In general formula (1), X is preferably an m-valent polyamino compound residue having a molecular weight of 1,000,000 or less, which may have a substituent other than an amino group. Here, the m-valent polyamino compound means that m acid amide bonds can be formed. It does not matter whether they are optical isomers such as D-form, L-form, and racemate.

Examples of such m-valent polyamino compounds include N, N′-dimethylhydrazine, ethylenediamine, N, N′-dimethylethylenediamine, diaminopropane, diaminobutane, diaminopentane, diaminohexane, diaminoheptane, diaminooctane, diaminononane, Aliphatic diamines such as diaminodecane, diaminododecane, diaminoadipic acid, diaminopropanoic acid, diaminobutanoic acid and their isomers;
Diethylenetriamine, triaminohexane, triaminododecane, 1,8-diamino-4-aminomethyl-octane, 2,6-diaminocapric acid-2-aminoethyl ester, 1,3,6-triaminohexane, 1,6 , 11-triaminoundecane, aliphatic triamines such as di (aminoethyl) amine and isomers thereof;
Alicyclic polyamines such as diaminocyclobutane, diaminocyclohexane, 3-aminomethyl-3,5,5-trimethylcyclohexylamine, triaminocyclohexane;
Aromatic polyamines such as diaminobenzene, diaminotoluene, diaminobenzoic acid, diaminoanthraquinone, diaminobenzenesulfonic acid, diaminobenzoic acid, and their respective isomers;
Araliphatic polyamines such as diaminoxylene, di (aminomethyl) benzene, di (aminomethyl) pyridine, di (aminomethyl) naphthalene, and their isomers;
And polyamines substituted with hydroxyl groups such as diaminohydroxypropane and isomers thereof.

In the general formula (1), X is preferably an m-valent polythiol compound residue having a molecular weight of 1,000,000 or less, which may have a substituent other than a thiol group. Here, the m-valent polythiol compound means that m thioester bonds can be formed. It does not matter whether they are optical isomers such as D-form, L-form, and racemate.
Examples of such m-valent polythiol compounds include dithiol compounds such as dithioethylene glycol, dithioerythritol, and dithiothreitol.
X is preferably a group having 1 to 40 carbon atoms among the residues of the compounds listed above, and more preferably X has 1 to 20 carbon atoms. X is preferably a naturally occurring type from the viewpoint of excellent biodegradability.

In general formula (2), the carboxyl group, sulfonic acid group, sulfate ester group, phosphate ester group represented by Y and the carboxyl group, sulfonate group, sulfate ester group, phosphate ester group, etc. that can be contained in X are: Salts can be formed with various basic substances.
Examples of such salts include alkali metal salts, alkaline earth metal salts, ammonium salts, organic amine salts, basic amino acid salts, polyvalent metal salts, and the like, specifically, alkalis such as sodium, potassium, and lithium. Metals, alkaline earth metals such as calcium and magnesium, metals such as aluminum, zinc, iron, cobalt, titanium and zirconium, organic amines such as ammonia, monoethanolamine, diethanolamine, triethanolamine and triisopropanolamine, arginine and lysine Or a salt with one or more kinds selected arbitrarily from basic amino acids and the like.

  As a method for producing the acyl compound represented by the general formula (1), an N-acyl acidic amino acid anhydride represented by the general formula (3) and a hydroxyl group, an amino group, or a thiol group in the molecule 1 By reacting a compound having two or more kinds of m functional groups with water and / or a mixed solvent with an organic solvent, or tetrahydrofuran, benzene, toluene, xylene, carbon tetrachloride, chloroform, acetone It can be obtained by reacting using an inert solvent such as, or by mixing at -5 ° C to 200 ° C at a temperature equal to or higher than any melting point without solvent.

  Alternatively, the acyl compound represented by the general formula (1) includes an N-acyl acidic amino acid mono-lower ester (for example, methyl ester, ethyl ester) and a polyhydroxyl compound, a polyamino compound, or a polythiol compound, or a hydroxyl group or an amino group in the molecule. , A compound having any two or three of the thiol groups is dissolved in a suitable solvent such as dimethylformamide, a catalyst such as potassium carbonate is added, and the reaction is performed at −5 ° C. to 250 ° C. under reduced pressure. Thereafter, it can be obtained by removing the reaction solvent. Alternatively, the acyl compound can be obtained by melting with heating without a solvent, adding a catalyst such as sodium hydroxide, and performing a transesterification reaction at room temperature to 250 ° C.

  The blending amount of the whitening cosmetic of the present invention is not particularly limited, but the content of the multi-chain polyhydrophilic group type compound is preferably 0.001 to 20% by mass, and can be adjusted according to the purpose. More preferably, it is 0.01-10 mass% in a composition, More preferably, it is 0.01-5 mass%. If the content of the multi-chain polyhydrophilic group type compound is less than the above range, the cosmetic stability and whitening effect may not be sufficient. Moreover, when it is more than the above range, a feeling such as stickiness may occur.

Examples of the whitening component of the component (B) to be blended in a preferred embodiment of the present invention include the following.
For example, ascorbic acid and salts thereof (sodium salt, potassium salt, magnesium salt, alkali metal salt such as calcium salt or alkaline earth metal salt, ammonium salt, amino acid salt, etc.),
Ascorbic acid derivatives (L-ascorbic acid alkyl ester, L-ascorbic acid phosphoric acid ester and its salt, L-ascorbic acid 2-sulfate and its salt, L-ascorbic acid glucoside, etc.),
Alkoxysalicylic acid and salts thereof (for example, methoxy group, ethoxy group, propoxy group, isopropoxy group, butoxy group, isobutoxy group etc.), hydroquinone glycosides and derivatives thereof (arbutin etc.), kojic acid and derivatives thereof , Ellagic acid, chamomile extract, altea extract, licorice extract, scorpion extract, raspberry extract, apple flavonoid, bran extract, vitamin E and its derivatives, hinokitiol, placenta extract, lucinol, chamomile ET, glutathione, clove extract, tea extract, One or more selected from astaxanthin, bovine placenta extract, tranexamic acid and its derivatives, derivatives of resorcin, azulene, γ-hydroxybutyric acid and the like can be used. The whitening component used in the present invention is not limited to those shown here, but includes those known as printed materials.

Examples of the anionic surfactant of component (C) to be blended in a preferred embodiment of the present invention include the following carboxyl group-containing ones.
For example, higher fatty acid salts (soaps); higher fatty acids having 8 to 20 carbon atoms in the hydrophobic group or salts thereof are also used as mixed fatty acids.
N-acyl amino acid type anionic surfactants; examples of acyl groups include those having 8 to 20 carbon atoms as described above, and examples of constituent amino acids include the above-mentioned acidic amino acids such as glutamic acid and aspartic acid Or glycine, alanine, valine, leucine, isoleucine, proline, methionine, cysteine, tryptophan, tyrosine, phenylalanine, asparagine, glutamine, serine, threonine, oxyproline, β-aminopropionic acid, γ-aminobutyric acid, anthranilic acid, m -Aminobenzoic acid, amino acids such as p-aminobenzoic acid, and the like.
Or alkyl ether carboxylate, amide ether carboxylate, etc. are mentioned.

In addition, examples of the anionic surfactant of the component (C) other than the component (A) to be blended in the preferred embodiment of the present invention include those other than those containing a carboxyl group as follows.
For example, alkane sulfonates, alpha-olefin sulfonates (AOS), alkyl benzene sulfonates, alkyl naphthalene sulfonates, alkyl sulfonates (SAS), sulfonates of higher fatty acid esters, alpha-sulfonated fatty acid salts, Higher fatty acid amide sulfonate, N-acyl-N-alkyltaurine salt, dialkylsulfosuccinate, sulfated oil, alkyl sulfate ester (AS), alkyl ether sulfate, sulfate of higher fatty acid ester, higher fatty acid alkyl Rollamide sulfate, polyoxyalkylene alkyl ether sulfate (AES), polyoxyalkylene styrenated phenyl ether sulfate, alkyl phosphate, alkyl ether phosphate, polyoxyethylene alkyl ether phosphate, Polyoxyethylene alkyl phenyl ether phosphates, naphthalenesulfonic acid salt formalin condensates and the like. Here, the counter ions of the salts of these anionic surfactants are arbitrarily selected from alkali metals, alkaline earth metals, ammonium ions, and organic ammonium ions. In the whitening cosmetic composition of the present invention, the anionic surfactant is preferably blended in an amount of 0.01 to 5% by mass, and two or more kinds may be mixed and used.
Among these, soaps, N-acyl amino acid salts, N-acyl alkyl taurine salts, sulfosuccinates, and polyoxyethylene alkyl ether sulfates are preferably blended.

  The nonionic surfactant of component (C) to be blended in a preferred embodiment of the present invention is a polyvalent polyhydride such as alkyl polyglucoside, (poly) glycerin fatty acid ester, propylene glycol fatty acid ester, sorbitan fatty acid ester, sho fatty acid ester and the like. Alcohol ester, polyoxyethylene alkyl ether (AE), polyoxyalkylene fatty acid ester, polyoxyalkylene sorbitan fatty acid ester, polyoxyalkylene fatty acid alkanolamide, polyoxyalkylene alkyl glucoside, polyoxyalkylene hydrogenated castor oil, polyoxyalkylene alkylamine, Polyoxyalkylene alkyl phenyl ether, polyoxyethylene polystyryl phenyl ether, polyoxyethylene polyoxypropylene al Ether, polyoxyethylene polyoxypropylene glycol, ethylene oxide condensation type, fatty acid alkanolamides and the like, sugars Amin'ashiru products, triethanolamine fatty acid partial esters, alkyl amine oxides, and the like. In the whitening cosmetic composition of the present invention, the nonionic surfactant is preferably blended in an amount of 0.01 to 5% by mass, and two or more kinds may be mixed and used.

In a preferred embodiment of the present invention, the amphoteric surfactant to be blended as component (C) includes alkylbetaines, alkylamidobetaines, alkylsulfobetaines, imidazolinium betaines, lecithins, etc. Specifically, lauric acid amidopropyl betaine is exemplified. In the whitening cosmetic composition of the present invention, the amphoteric surfactant is preferably blended in an amount of 0.01 to 5% by mass, and two or more kinds may be mixed and used.
The cationic compound of component (C) to be blended in a preferred embodiment of the present invention includes primary to tertiary fatty amine salts, alkyl chloride ammonium salts, tetraalkyl ammonium salts, trialkyl benzyl ammonium salts, alkyl pyridinium salts, Cationic surfactants such as alkylhydroxyethyl imidazolinium salt, dialkylmorpholinium salt, alkylisoquinolium salt, benzethonium salt, benzalkonium salt, and the like, and counterions of these include chlorine, iodine, bromine, etc. Organic anions such as halogen ions, methosulfate, ethosulfate, methophosphate, ethophosphate. In the whitening cosmetic composition of the present invention, the cationic surfactant is preferably blended in an amount of 0.01 to 5% by mass, and two or more kinds may be mixed and used.

Examples of the component (D) polyhydroxyl compound to be blended in a preferred embodiment of the present invention include bivalent or higher polyhydroxyl compounds as described above. These polyhydroxyl compounds are preferably blended in an amount of 0.1 to 30% by weight in the whitening cosmetic composition, and two or more kinds may be mixed and used.
Further, the whitening cosmetic composition of the present invention can be used in a wide pH range of preferably 3 to 12, more preferably by adjusting the neutralization rate with a basic substance, more preferably pH 4.5 to 11 of the composition. Can be used in More preferably, it can be used at pH 5-8.
The whitening cosmetic of the present invention can be produced by a method using an apparatus equipped with a normal stirrer, mixer, disperser and the like.

Moreover, in the whitening cosmetics of this invention, unless the objective of this invention is impaired, it can be used together with various base materials according to a use and the objective.
Specifically, natural rubbers such as gum arabic and tragacanth, glucosides such as saponin, cellulose derivatives such as methylcellulose, carboxycellulose, and hydroxymethylcellulose, natural polymers such as lignin sulfonate and shellac, polyacrylates, Styrene-acrylic acid copolymer salt, vinyl naphthalene-maleic acid copolymer salt, β-naphthalene sulfonic acid formalin condensate sodium salt, anionic polymer such as phosphate, polyvinyl alcohol, polyvinyl pyrrolidone, Dispersants such as nonionic polymers such as polyethylene glycol;
Etc.

Polymeric surfactants such as sodium alginate, starch derivatives, tragacanth gum;
Natural surfactants such as phospholipids, lecithin, lanolin, cholesterol, saponins;
Avocado oil, almond oil, olive oil, cacao oil, sesame oil, safflower oil, soybean oil, camellia oil, persic oil, castor oil, mink oil, cottonseed oil, owl, palm oil, egg yolk oil, palm oil, palm kernel oil, synthetic triglyceride, Fats and oils such as jojoba oil;
Hydrocarbons such as liquid paraffin, petrolatum, ceresin, microcrystalline wax, isoparaffin;
Waxes such as beeswax, whale wax, lanolin, carnauba wax, candelilla wax and derivatives thereof;
Higher fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, oleic acid, behenic acid, undecylenic acid, lanolin fatty acid, hard lanolin fatty acid, soft lanolin fatty acid;

Higher alcohols such as lauryl alcohol, cetanol, cetostearyl alcohol, stearyl alcohol, oleyl alcohol, behenyl alcohol, lanolin alcohol, hydrogenated lanolin alcohol, hexyldecanol, octyldodecanol;
Other ester oils such as isopropyl myristate and butyl stearate;
Metal soap, dimethylpolysiloxane, polyether-modified silicone, alcohol-modified silicone, methylphenylpolysiloxane, epoxy-modified silicone, fluorine-modified silicone, alkyl-modified silicone, alkoxy-modified silicone, amino-modified silicone, volatile silicone and other silicones Volatile and non-volatile oils;
Moisturizers such as trimethylglycine, sorbitol, raffinose, pyrrolidone carboxylates, lactates, hyaluronates, ceramides;

Cationized cellulose derivative, cationic starch, cationized guar gum derivative, diallyl quaternary ammonium salt / acrylamide copolymer, quaternized polyvinylpyrrolidone derivative, quaternized vinylpyrrolidone / vinylimidazole polymer, polyglycol / amine condensate, Cationic compounds such as quaternized collagen polypeptides, polyethyleneimine, cationic silicone polymers, adipic acid / dimethylaminohydroxypropyldiethylenetriamine copolymers, polyaminopolyamides, cationic chitin derivatives, cationic polymers such as quaternized polymers;
Hydroxyethylcellulose, carboxymethylcellulose, hydroxyethylcellulose hydroxypropyltrimethylammonium chloride ether, methylcellulose, ethylcellulose, hydroxypropylcellulose, methylhydroxypropylcellulose, soluble starch, carboxymethylstarch, methylstarch,
Propylene glycol alginate, polyvinyl alcohol, polyvinyl pyrrolidone, polyvinyl methyl ether, carboxyvinyl polymer, polyacrylate, guar gum, locust bin gum, quince seed, carrageenan, galactan,

Gum arabic, pectin, mannan, starch, xanthan gum, dextran, succinoglucan, curdlan, hyaluronic acid, gelatin, casein, albumin, collagen, methoxyethylene maleic anhydride copolymer, amphoteric methacrylate copolymer, polychlorinated Water-soluble and oil-soluble polymers such as dimethylmethylene piperidinium, polyacrylate copolymer, polyvinyl acetate, nitrocellulose, silicone resin;
Thickening and foam increasing components such as polyethylene glycol fatty acid ester, polyoxyethylene fatty acid ester methyl glycoside, tetradecene sulfonate;
Sequestering agents such as ethylenediaminetetraacetic acid and its salts, hydroxyethylenediaminetriacetic acid and its salts, phosphoric acid, ascorbic acid, succinic acid, gluconic acid, polyphosphates, metaphosphates, hinokitiles;
Preservatives such as paraoxybenzoates, benzoic acid and its salts, phenoxyethanol, hinokitile;
PH adjusters such as citric acid, malic acid, adipic acid, glutamic acid, aspartic acid;
Other anti-dandruff and itching agents such as trichlorocarbanilide, salicylic acid, zinc pyrithione, isopropylmethylphenol;

Benzophenone derivatives, paraaminobenzoic acid derivatives, paramethoxycinnamic acid derivatives, salicylic acid derivatives and other UV absorbers;
Blood circulation promoters such as assembly extract, cephalanthin, vitamin E and its derivatives, gamma oryzanol;
Local stimulants such as pepper tincture, ginger tincture, cantharis tincture, nicotinic acid benzyl ester;
Nutrients such as various vitamins and amino acids;
Female hormone agent;
Hair root activator;
Anti-inflammatory agents such as glycyrrhetinic acid, glycyrrhizic acid derivatives, allantoin, azulene, aminocaproic acid, hydrocortisone;
Astringents such as zinc oxide, zinc sulfate, allantoin hydroxyaluminum, aluminum chloride, zinc sulfocolate, tannic acid;
Refreshing agents such as menthol and camphor;
Antihistamines;
Silicone materials such as high molecular silicones and cyclic silicones;
Antioxidants such as tocopherols, BHA, BHT, gallic acid and NDGA; sebum inhibitors such as estradiol, estrone and ethinyl estradiol;
Exfoliating / dissolving agents such as sulfur, salicylic acid, resorcin;

  Organic pigments (dyes, lakes, organic pigments), natural pigments, inorganic pigments (external pigments, colored pigments, white pigments), pearlescent pigments, polymer powders, and functional pigments can be broadly classified into spheres and plates In addition, it can be used in a shape such as a needle shape, a particle size such as fumes, fine particles, and a pigment grade, and is not limited to a particle structure such as porous or nonporous. For example, talc, kaolin, sericite, calcium carbonate, zinc oxide, aluminum oxide, magnesium oxide, zirconium oxide, magnesium carbonate, calcium carbonate, barium sulfate, chromium oxide, chromium hydroxide, tar dyes, mica, (synthetic) seric Site, silicon carbide, boron nitride, titanium dioxide, black titanium oxide, conger, red iron oxide, black iron oxide, yellow iron oxide, ultramarine, titanium coated mica, bismuth oxychloride, bengara, caking pigment, gunjo pink, gun Zou violet, chromium hydroxide, mica titanium, chromium oxide, aluminum cobalt oxide, carbon black, anhydrous silicic acid, magnesium silicate, bentonite, (synthetic) mica, zirconium oxide, magnesium (meth) silicate aluminate, aluminum silicate Calcium oxide, Liethylene powder, nylon powder, polymethyl methacrylate, polyethylene terephthalate-polymethyl methacrylate laminate powder, acrylonitrile-methacrylic acid copolymer powder, vinylidene chloride-methacrylic acid copolymer powder, wool powder, silk powder, crystalline cellulose, N-acyl lysine, poly Methyl silsesquioxane powder, plant fruit or skin powder, bismuth oxychloride, mica titanium, iron oxide coated mica, iron oxide mica titanium, organic pigment treated mica titanium, aluminum powder, fine particle titanium oxide, fine particle Zinc oxide, fine particle titanium oxide coated mica titanium, fine particle zinc oxide coated mica titanium, barium sulfate coated mica titanium, carmine, β-carotene, chlorophyll, sunset yellow FCF, Ponceau SX, eosin YS, TE Trabromofluorescein, rhodamine B, quinoline yellow SS, quinoline yellow WS, alizanin cyanine green, quinizarin green, resolbin BCA, resolbin BCA, permaton red, herringdon pink CN, phthalocyanine blue, β-apo-8-carotenal , Capsanthin, lylopine, bixin, crocin, canthaxanthin, shisonin, raphanin, ninocyanin, calsamine, safrole yellow, rutin, quercetin, cacao dye, lipoflavin, lacaic acid, carminic acid, kermesic acid, alizanin, shikonin, alkanine, niquinochrome, blood dye , Curcumin, betanin, etc.

  Purified water, others, oyster extract, N-methyl-L-serine, whey, nicotinamide, diisopropylamine dichloroacetic acid, mevalonic acid, γ-aminobutyric acid (including γ-amino-β-hydroxybutyric acid), altea extract, Aloe extract, apricot kernel extract, turmeric extract, oolong tea extract, dried sea water, hydrolyzed wheat powder, hydrolyzed silk, carrot extract, cucumber extract, gentian extract, yeast extract, rice germ oil, comfrey extract, savonso extract, Giant extract, lion extract, birch extract, Atlantic mint extract, assembly extract, bisabolol, propolis, loofah extract, bodaiju extract, hop extract, marronnier extract, muroji extract, melissa extract, eucalyptus extract, yukinoshita extract, rosemary Can kiss, Roman chamomile extract, royal jelly extract, seaweed, rice bran, licorice, citrus unshiu peel, angelica, pulverized Momonoha, sphingolipids, guaiazulene, may contain vitamin C, and the like.

In particular, combined use with fatty acid diethanolamide, polyoxyethylene dioleic acid methyl glucoside, polyethylene glycol distearate, tetradecene sulfonate, myristic acid salts, myristyl dimethylamine is useful in terms of increasing viscosity and foaming power. In addition, the combined use with each zwitterionic surfactant is extremely useful in that the irritation is further reduced.
The whitening cosmetic of the present invention includes all cosmetics and detergents applied to the outer skin, and the forms thereof are also aqueous solutions, solubilization systems such as skin lotions, emulsion systems such as emulsions and creams, powder systems, oil liquid systems. , Gel systems, ointment systems, water-oil two-layer systems, water-oil-powder three-layer systems, and the like.

  Hereinafter, the present invention will be described more specifically with reference to examples and the like. However, the present invention is not limited to the examples and the like.

The evaluation means used in the examples of the present invention are as follows.
(Skin irritation test)
After applying 0.1 g of the sample to the forearm flexion skin of 5 healthy male panelists for 3 days, the presence or absence of skin irritation was evaluated. The determination result is indicated by a case where the average score of the following evaluation points is 0 point or more and less than 1 point: ◯, when 1 point or more and less than 2 points: Δ, when 2 points or more: ×.
Judgment criteria and evaluation points Erythema, edema, blisters (4 points)
Erythema, edema (3 points)
Erythema (2 points)
Minor erythema (1 point)
No erythema, edema (0 points)

(Storage stability)
Stability over time (1): After the sample was stored at 40 ° C. for 1 month, the appearance was visually observed and evaluated according to the following criteria. Judgment criteria are shown as follows.
Good (O): Aggregation is not recognized for 3 months or more.
Slightly poor (Δ): Aggregation was observed from 1 month to 3 months.
Poor (x): Aggregation was observed in less than 1 month.

(Production Example 1 of acyl compound)
9.1 g (0.05 mol) of L-lysine hydrochloride was mixed with 57 g of water. While this solution was adjusted to a pH range of 10 to 11 with a 25% aqueous sodium hydroxide solution and the reaction temperature was maintained at 5 ° C., 31.1 g of N-lauroyl-L-glutamic anhydride (0. 1 mol) was added over 2 hours to carry out the reaction. After further stirring for 2 hours, tertiary butanol was added to a concentration of 20% by mass in the liquid, 75% sulfuric acid was added dropwise to bring the pH value of the liquid to 2, and the liquid temperature to 65 ° C. It was adjusted. After completion of the dropwise addition, stirring was stopped and the mixture was allowed to stand at 65 ° C. for 20 minutes, so that the organic layer and the aqueous layer were separated, and the organic layer was separated therefrom. Tertiary butanol and water were added to the separated organic layer, the temperature was raised to 65 ° C., and the mixture was stirred for 20 minutes. After the stirring was stopped, the mixture was allowed to stand to separate into an organic layer and an aqueous layer. After repeating the same water washing operation for the obtained organic layer, the solvent was removed from the obtained organic layer and neutralized with sodium hydroxide to an aqueous solution having a solid content of 30% by mass and a pH of 6.5 (25 ° C.). After the preparation, this was dried to obtain a composition containing an acyl compound represented by the formula (4).

(In Formula 4, each X is independently H or Na)
(Production Example 2 of acyl compound)
A composition containing an acyl compound, carried out under the same conditions as in Production Example 1, except that 31.1 g of N-lauroyl-L-glutamic acid anhydride is changed to N-cocoyl-L-glutamic acid anhydride in Production Example 1. I got a thing.

[Examples 1-9, Comparative Examples 1-2]
Each component shown in Table 1 was used in the blending amount shown in Table 1 to prepare a whitening cosmetic. Table 1 shows the results of evaluation for each whitening cosmetic.

[Example 10]
The following whitening cosmetics were prepared. The evaluation results for the stability, skin irritation, and whitening effects of the cosmetics were all good.
(Composition) (Mass)
(1) Stearic acid 4
(2) Stearyl alcohol 4
(3) Butyl stearate 6
(4) Propylene glycol 5
(5) Glycerol monostearate 2
(6) Potassium hydroxide 0.2
(7) Acyl compound 1 of Production Example 1
(8) L-ascorbic acid distearate 1
(9) Perfume appropriate amount (10) Preservative / antioxidant appropriate amount (11) Purified water 76

[Example 11]
The following whitening cosmetics were prepared. The evaluation results for the stability, skin irritation, and whitening effects of the cosmetics were all good.
(Composition) (Mass)
(1) Stearic acid 2
(2) Stearyl alcohol 5
(3) Hydrogenated lanolin 5
(4) Squalane 9
(5) Octyldodecanol 10
(6) 1,3-butylene glycol 5
(7) Polyethylene glycol (mw 1500) 5
(8) Acyl compound 1 of Production Example 2
(9) Arbutin 5
(10) Perfume appropriate amount (11) Preservative / antioxidant appropriate amount (12) Purified water 53

[Example 12]
The following whitening cosmetics were prepared. The evaluation results for the stability, skin irritation, and whitening effects of the cosmetics were all good.
(Composition) (Mass)
(1) Stearic acid 2
(2) Cetyl alcohol 1.5
(3) Vaseline 4
(4) Squalane 4
(5) Glycerol tri-2-ethylhexanoate 2
(6) Dipropylene glycol 5
(7) Polyethylene glycol (mw1500) 3
(8) Acyl compound 1 of Production Example 1
(9) Sodium ascorbate sulfate 5
(10) Perfume appropriate amount (11) Preservative / antioxidant appropriate amount (12) Purified water 72

[Example 13]
The following whitening cosmetics were prepared. The evaluation results for the stability, skin irritation, and whitening effects of the cosmetics were all good.
(Composition) (Mass)
(1) Ethanol 15
(2) Glycerin 2
(3) Liquid paraffin 3
(4) Dimeryl silicone (20 cSt) 2
(5) Carboxyvinyl polymer 0.3
(6) Propylene glycol 5
(7) Hydroxypropyl cellulose 0.1
(8) Acyl compound 1 of Production Example 1
(9) Sodium ascorbate 2
(10) Perfume appropriate amount (11) Preservative / antioxidant appropriate amount (12) Purified water 71

[Example 14]
The following whitening cosmetics were prepared. The evaluation results for the stability, skin irritation, and whitening effects of the cosmetics were all good.

(Composition) (Mass)
(1) Polyethylene glycol (mw 1500) 10
(2) Dipropylene glycol 5
(3) Methylcellulose 0.2
(4) Carboxyvinyl polymer 0.4
(5) Acyl compound 1 of Production Example 1
(6) Potassium hydroxide 0.1
(7) Tranexamic acid 1.5
(9) Ascorbic acid-2-glucoside 2
(10) Perfume appropriate amount (11) Preservative / antioxidant appropriate amount (12) Chelating agent appropriate amount (13) Purified water 79

  INDUSTRIAL APPLICABILITY The present invention can be suitably used as a whitening cosmetic composition that is excellent in cosmetic stability, exhibits a sufficient whitening effect, and has little irritation.

Claims (9)

Whitening cosmetics characterized by containing the following component (A).
Component (A): One or more of a multi-chain polyhydrophilic group-type surfactant having two or more long-chain hydrophobic groups and hydrophilic groups in the molecule.   At least one of the multi-chain polyhydrophilic group-type surfactant has a long-chain hydrophobic group as a long-chain acyl group, and a hydrophilic group as a carboxyl group, sulfonic acid group, sulfate ester group, phosphate ester group and salts thereof The whitening cosmetic according to claim 1, wherein the whitening cosmetic is an anionic surfactant that is at least one selected from the group consisting of:   3. The whitening cosmetic according to claim 1, wherein at least one of the multi-chain polyhydrophilic group-type surfactant further has an amino acid residue in the molecule. The whitening cosmetic composition according to any one of claims 1 to 3, wherein at least one of the multi-chain polyhydrophilic group-type surfactant is a compound represented by the general formula (1).

(In the general formula (1), X is a linear, branched, cyclic or aromatic hydrocarbon chain having a molecular weight of 1 million or less, which may have m functional groups and other substituents. 1 represents a spacer, and n (m ≧ n) Q bonded to X are substituents represented by the general formula (2), and may be the same as or different from each other. ), Z is a bond derived from a functional group of X, R ¹ CO represents a long-chain acyl group derived from a saturated or unsaturated fatty acid having 8 to 20 carbon atoms, and R ² represents hydrogen Or a lower alkyl group having 1 to 3 carbon atoms which may be substituted by a hydroxyl group or a carboxyl group, and Y represents a carboxyl group, a sulfonic acid group, a sulfate ester group, a phosphate ester group or a group thereof. One of the salt J and k are each independently 0, 1, or 2, and j and k are not simultaneously 0. n represents an integer of 2 to 20. m is an integer satisfying m ≧ n. Is shown.)

  At least one of the multi-chain polyhydrophilic group type surfactant is a compound represented by the general formula (1), and in the general formula (1), X may have a substituent other than the functional group. The whitening cosmetic composition according to any one of claims 1 to 4, wherein the whitening cosmetic composition is a spacer that is a straight chain, branched chain, cyclic chain, or aromatic hydrocarbon chain.   Furthermore, 1 or more types of component (B): whitening component are contained, The whitening cosmetics in any one of Claims 1-5 characterized by the above-mentioned.   Furthermore, whitening cosmetics in any one of Claims 1-6 containing 1 or more types chosen from component (C): anionic surfactant, an amphoteric surfactant, and a cationic surfactant.   The whitening cosmetic composition according to any one of claims 1 to 7, further comprising at least one component (D): a polyhydroxyl compound.   A whitening method using the whitening cosmetic composition according to any one of claims 1 to 8.