JP2006225368A - Gel composition and method for preparing the same - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a transparent or a translucent gel composition having extremely light slip when skin, etc., are coated with a gel-like oily ingredient and massage is carried out, excellent stability with time and a good feeling of use and to provide a method for preparing the gel composition. <P>SOLUTION: The gel composition is characterized as follows. The gel composition comprises one or two or more kinds of multi-chain and multi-hydrophilic group type compounds having ≥2 long-chain hydrophobic groups and ≥2 hydrophilic groups in the molecule, respectively, one or two or more kinds of polyhydroxyl compounds having ≥2 hydroxy groups in the molecule and the one or two or more kinds of oily ingredients. The degree of neutralization for the acid value of the multi-chain and multi-hydrophilic group type surfactant contained therein is ≥0.1 to <0.9. The method for preparing the gel composition is characterized as mixing at least one kind of regulator for the degree of neutralization selected from the group consisting of an organic acid, an inorganic acid, an organic base and an inorganic base and regulating the degree of neutralization for the acid value of the multi-chain and multi-hydrophilic group type compounds to ≥0.1 to <0.9. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  TECHNICAL FIELD The present invention relates to a gel composition having a very light oily component and a very light spread during friction, a method for preparing the gel composition, and particularly to a gel composition useful as a cosmetic product.

  Examples of the gel containing an oil component include a gel-like composition formed from a water-soluble polymer (see Patent Document 1), an oil gel obtained by gelling oil with a gelling agent (see Patent Document 2), and an oil-in-water type. And an emulsified gel composition (see Patent Document 3) and a water-in-oil emulsified gel composition (see Patent Document 4). The use of the gel composition containing such an oil component includes a cosmetic use such as a cleansing cosmetic. In order to wash off makeup cosmetics containing a large amount of oily ingredients, it is considered that the best method is to use a detergent containing oily ingredients. What is required for cleansing cosmetics is not only the degree of dirt removal and the stability of the product over time, but also a feeling of use such as easiness of elongation when applied and rubbed on the skin or the like.

Japanese Patent Publication No. 6-37575 JP 2000-344620 A Japanese Patent Publication No. 1-53845 Japanese Patent Publication No.1-14266

  The present invention provides a transparent to translucent gel composition that is very light in elongation when applied to a skin or the like with a gel-like oily component and has excellent stability over time, and is easy to use. It is an object to provide a method for preparing the gel composition.

  As a result of intensive studies to solve the above problems, the present inventors have determined that a specific surfactant, that is, a multi-chain polyhydrophilic group type having two or more long-chain hydrophobic groups and hydrophilic groups in the molecule. In the compound, by making the degree of neutralization with respect to the acid value in a certain range, the elongation is particularly light and excellent when the gel composition is applied to the skin, etc. while stably mixing the oil component in a gel form. Moreover, since this composition has extremely good dispersibility in water, it has been found that this gel composition is useful as a cosmetic product with excellent usability. Furthermore, the neutralization degree with respect to the acid value of the polychain polyhydrophilic group type compound is at least one neutralization degree adjusting agent selected from the group consisting of an organic acid, an inorganic acid, an organic base, and an inorganic base in the gel composition. It was found that it can be easily adjusted to a specific range by mixing, and the present invention has been completed.

That is, the present invention is as follows.
1. Among the multi-chain polyhydrophilic group type compounds having two or more long-chain hydrophobic groups and hydrophilic groups in the molecule, the degree of neutralization with respect to the acid value of the multi-chain polyhydrophilic group type compound is 0.1 to 0. 1 type or 2 types or more of less than 9 types, 1 type or 2 types or more of polyhydroxyl compounds having 2 or more hydroxyl groups in the molecule, and 1 type or 2 types or more of oily components Gel composition.
2. With respect to the acid value of the multi-chain polyhydrophilic group-type compound by at least one neutralization degree adjusting agent selected from the group consisting of organic acids, inorganic acids, organic bases, and inorganic bases mixed and contained in the gel composition 1 type or 2 types or more containing what was adjusted to 0.1 or more and less than 0.9 is characterized by the above-mentioned. The gel composition as described in 2.

3. The water content in the gel composition is 50% by weight or less, and the composition in the gel composition is 1) the total amount of the multi-chain polyhydrophilic group type compound is 0.1 to 40% by weight, 2) polyhydroxyl The total amount of the compound is 1 to 60% by weight, 3) The total amount of the oily component is 1 to 95% by weight, 4) At least one neutralization degree adjustment selected from the group consisting of organic acids, inorganic acids, organic bases and inorganic bases The total amount of the agent is 0 to 10% by weight (provided that 1) to 4) are 100% by weight in total. 1). Or 2. The gel composition as described in 2.
4). At least one of the multi-chain polyhydrophilic group type compounds in the gel composition has an amino acid residue in the molecule. ~ 3. The gel composition according to any one of the above.

  5. 1. At least one of the multi-chain polyhydrophilic group type compounds in the gel composition is a compound represented by the following general formula (1): ~ 4. The gel composition according to any one of the above.

(In the above general formula (1), n Zs are bonding parts derived from m functional groups substituted with X (m ≧ n), which are independent, that is, may be the same or different, X is a spacer which is a straight chain, branched chain, cyclic chain or aromatic hydrocarbon chain having a molecular weight of 1,000,000 or less, which may have a substituent other than the functional group, and is attached to X via Z The substituents represented by the following general formula (2) are each independent, that is, they may be the same or different,
R ¹ CO represents a long-chain acyl group derived from a saturated or unsaturated fatty acid having 8 to 20 carbon atoms, R ² is hydrogen, or a carbon which may be substituted by a hydroxyl group or a carboxyl group A lower alkyl group having 1 to 3 atoms; Y represents a carboxyl group, a sulfonic acid group, a sulfate ester group, a phosphate ester group and / or a salt thereof; j and k are each independently 0, 1, 2; And j and k are not 0 at the same time, and n is an integer of 2 to 20)

6). At least one of the multi-chain polyhydrophilic group type compounds in the gel composition is a compound represented by the general formula (1), and in the general formula (1), X has a substituent other than the functional group. 1. A spacer which is a linear, branched, cyclic or aromatic hydrocarbon chain having 1 to 40 carbon atoms which may be ~ 5. The gel composition according to any one of the above.
7). When the gel composition is applied to the skin or the like and rubbed, the gel composition is used as a cleansing cosmetic that is very light in elongation and has a good feeling of use. ~ 6. The gel composition according to any one of the above.
8). With respect to the acid value of the multi-chain polyhydrophilic group-type compound by at least one neutralization degree adjusting agent selected from the group consisting of organic acids, inorganic acids, organic bases, and inorganic bases mixed and contained in the gel composition 1. Adjusting the sum to 0.1 or more and less than 0.9. ~ 7. A method for preparing a gel composition according to any one of the above.

  The gel composition of the present invention is a multi-chain polyhydrophilic group type compound having two or more long-chain hydrophobic groups and hydrophilic groups in the molecule, and the degree of neutralization with respect to the acid value is 0.1 to less than 0.9 Or a neutralization degree with respect to an acid value of 0.1 or more by mixing a gel composition and at least one neutralization degree adjusting agent selected from the group consisting of an organic acid, an inorganic acid, an organic base, and an inorganic base However, as shown in the examples, the gel composition produced using a surfactant having a specific neutralization degree is neutralized outside this range. It is clear that the static friction coefficient is reduced during friction as compared with the case of using a surfactant of a certain degree, and the elongation is very light even in sensory evaluation, and the stability is high. In addition, the ease of preparation of the gel composition is useful in production.

Hereinafter, the present invention will be described in detail, particularly focusing on its embodiments.
In the present invention, the degree of neutralization of one or two or more acid values of the multi-chain polyhydrophilic group type compound contained therein is 0.1 or more and less than 0.9, preferably an acid. The neutralization degree with respect to the value is 0.1 or more and less than 0.7. More preferably, it is 0.2 or more and less than 0.5. Here, even if the degree of neutralization with respect to the acid value is outside this range, it may become a gel-like dosage form, but the oily component is separated and the stability is poor, the elongation is poor, May become unfavorable.

  In the gel composition of the present invention, the degree of neutralization with respect to one or more acid values of the multi-chain polyhydrophilic group type compound contained therein is 0.1 or more and less than 0.9, Preferably, the neutralization degree with respect to the acid value is 0.1 or more and less than 0.7. More preferably, it is 0.2 or more and less than 0.5. Here, even if the degree of neutralization with respect to the acid value is outside this range, it may become a gel-like dosage form, but the oily component is separated and the stability is poor, the elongation is poor, May become unfavorable.

  As the at least one neutralization degree adjusting agent selected from the group consisting of an organic acid, an inorganic acid, an organic base, and an inorganic base to be mixed in the gel composition, a medium for the acid value of the multi-chain polyhydrophilic group type compound is used. There is no particular limitation as long as the sum can be adjusted to 0.1 or more and less than 0.9, but 1% by weight in a mixture of a polyhydroxyl compound having two or more hydroxyl groups in the molecule or a mixture thereof and water. Those that can be dissolved or uniformly mixed are preferred.

  Examples of the organic acid include acrylic acid, adipic acid, ascorbic acid, benzoic acid, phenylacetic acid, cinnamic acid, 3-phenylpropionic acid, edetic acid, citric acid, glycolic acid, glucuronic acid, gellanic acid, acetic acid, propion Acid, pyruvic acid, butyric acid, isobutyric acid, 2-methylbutyric acid, 2-ethylbutyric acid, valeric acid, isovaleric acid, 2-methylvaleric acid, 3-methylvaleric acid, hexanoic acid, isohexanoic acid, 2-hexanoic acid, 4-pentenoic acid, 2-methyl-2-pentenoic acid, heptanoic acid, 2-methylheptanoic acid, octanoic acid, nonanoic acid, decanoic acid, 2-decenoic acid, undecylenic acid, dodecanoic acid, myristic acid, palmitic acid, stearin Acid, anthranilic acid, oleic acid, levulinic acid, gluconic acid, succinic acid, salicylic acid, oxalic acid, tartaric acid, carbonic acid, nicotinic acid, Acid, fumaric acid, pyrrolidone carboxylic acid, phthalic acid, malonic acid, malic acid, vanillic acid, abietic acid, sorbic acid, aspartic acid, glutamic acid.

Examples of inorganic acids include hydrochloric acid, nitric acid, nitrous acid, sulfuric acid, sulfurous acid, phosphoric acid, phosphonic acid, phosphinic acid, and the like.
Examples of the organic base include trimethylamine, triethylamine, tributylamine, 2-amino-2-methylpropanol, triethanolamine, triisopropanolamine, monoethanolamine, diethanolamine, and tris [(2-hydroxy) -1-propyl] amine. 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1,3-propanediol, arginine, ornithine, histidine, lysine and the like.

Examples of the inorganic base include aqueous ammonia, sodium hydroxide, potassium hydroxide, ammonium hydroxide, sodium carbonate, sodium hydrogen carbonate and the like.
In the gel composition of the present invention, as the multi-chain polyhydrophilic group-type compound, each of the long-chain hydrophobic groups is independently a saturated or unsaturated straight chain, branched chain, or cyclic chain having 8 to 20 carbon atoms. Each of the hydrophilic groups independently includes a carboxyl group, a sulfonic acid group, a sulfuric acid residue, a phosphoric acid residue or a salt thereof, an oxyalkylene group, a polyethylene glycol group, or the like, or an amino group, It has a quaternary ammonium group, a pyridinium group, a sulfonium group or a salt thereof.

For example, the long-chain hydrophobic group of the multi-chain poly-hydrophilic group type compound includes, for example, n-octyl, n-nonyl, n-decyl, n-undecyl, n-dodecyl, n-tridecyl, n-tetradecyl, n-pentadecyl. , N-hexadecyl, n-heptadecyl, n-octadecyl, n-nonadecyl, n-eicosyl, etc. and their branched isomers, and corresponding one, two or three non-residues Examples include unsaturated residues having a saturated portion.
The long-chain hydrophobic group of the multi-chain polyhydrophilic group-type compound is a long-chain acyl group derived from a saturated or unsaturated fatty acid having 8 to 20 carbon atoms,

Linear fatty acids such as caprylic acid, pelargonic acid, capric acid, undecanoic acid, lauric acid, tridecanoic acid, myristic acid, pentadecanoic acid, palmitic acid, margaric acid, stearic acid, nonadecanoic acid, arachidic acid;
2-butyl-5-methylpentanoic acid, 2-isobutyl-5-methylpentanoic acid, dimethyloctanoic acid, dimethylnonanoic acid, 2-butyl-5-methylhexanoic acid, methylundecanoic acid, dimethyldecanoic acid, 2-ethyl- 3-methylnonanoic acid, 2,2-dimethyl-4-ethyloctanoic acid, methyldocosanoic acid, 2-propyl-3-methylnonanoic acid, methyltridecanoic acid, dimethyldodecanoic acid, 2-butyl-3-methylnonanoic acid, methyltetradecanoic acid , Ethyltridecanoic acid, propyldodecanoic acid, butylundecanoic acid, pentyldecanoic acid, hexylnonanoic acid, 2- (3-methylbutyl) -3-methylnonanoic acid, 2- (2-methylbutyl) -3-methylnonanoic acid, butylethylnonane acid,

Methylpentadecanoic acid, ethyltetradecanoic acid, propyltridecanoic acid, butyldodecanoic acid, pentylundecanoic acid, hexyldecanoic acid, heptylnonanoic acid, dimethyltetradecanoic acid, butylpentylheptanoic acid, trimethyltridecanoic acid, methylhexadecanoic acid, ethylpentadecanoic acid, propyl Tetradecanoic acid, butyltridecanoic acid, pentyldodecanoic acid, hexylundecanoic acid, heptyldecanoic acid, methylheptylnonanoic acid,
Dipentylheptanoic acid, methylheptadecanoic acid, ethylhexadecanoic acid, ethylhexadecanoic acid, propylpentadecanoic acid, butyltetradecanoic acid, pentyltridecanoic acid, hexyldecanoic acid, heptylundecanoic acid, octyldecanoic acid, dimethylhexadecanoic acid,

Branched fatty acids such as methyloctylnonanoic acid, methyloctadecanoic acid, ethylheptadecanoic acid, dimethylheptadecanoic acid, methyloctyldecanoic acid, methylnonadecanoic acid, methylnonadecanoic acid, dimethyloctadecanoic acid, butylheptylnonanoic acid;
Octenoic acid, nonenoic acid, decenoic acid, caproleic acid, undecylenic acid, Lindellic acid, touric acid, lauroleic acid, tridecenoic acid, tuzuic acid, myristoleic acid, pentadecenoic acid, hexedenoic acid, palmitoleic acid, heptadecenoic acid, octadecenoic acid, Linear monoenoic acids such as oleic acid, nonadecenoic acid, gondoic acid;
Methylheptenoic acid,

Branched monoenoic acids such as methylnonenoic acid, methylundecenoic acid, dimethyldecenoic acid, methyldodecenoic acid, methyltridecenoic acid, dimethyldodecenoic acid, dimethyltridecenoic acid, methyloctadecenoic acid, dimethylheptadecenoic acid, ethyloctadecenoic acid ;
Di- or trienoic acids such as linoleic acid, linoleic acid, eleostearic acid, linolenic acid, linolenic elaidic acid, pseudoeleostearic acid, parinaric acid, arachidonic acid;

Acetylene acids such as octinoic acid, nonic acid, decinic acid, undecinic acid, dodecinic acid, tridecinic acid, tetradecinic acid, pentadecinic acid, heptadesinic acid, octadecinic acid, nonadesinic acid, dimethyloctadesinic acid;
Of methyleneoctadecenoic acid, methyleneoctadecanoic acid, aleprolic acid, alepresinic acid, allepuric acid, alepuric acid, hydnocarpic acid, shoulmuric acid, gorulic acid, α-cyclopentylic acid, α-cyclohexylic acid, α-cyclopentylethylic acid And acyl groups derived from such cyclic acids.

  Moreover, the acyl group derived from the fatty acid obtained from natural fats and oils may be sufficient, and what is necessary is just the acyl group derived from the mixed fatty acid containing 80% or more of said saturated or unsaturated fatty acid having 8-20 carbon atoms. For example, acyl groups derived from palm oil fatty acid, palm oil fatty acid, linseed oil fatty acid, sunflower oil fatty acid, soybean oil fatty acid, sesame oil fatty acid, castor oil fatty acid, olive oil fatty acid, camellia oil fatty acid, rapeseed oil fatty acid, palm kernel oil fatty acid, etc. Etc. The long-chain hydrophobic group is a long-chain acyl group, and the long-chain hydrophobic group in the molecule is preferably the same. Two or more of these polychain polyhydrophilic group type compounds may be used in combination.

  In the gel composition of the present invention, as an example of a multi-chain polyhydrophilic group type compound, structurally, a surfactant having at least one long-chain hydrophobic group and at least one hydrophilic group in the molecule is used as a suitable spacer. This structure may be used as long as it is a structure linked to each other, and any compound known so far may be used. The spacer is preferably a linear, branched, cyclic, or aromatic hydrocarbon chain having a molecular weight of 1,000,000 or less, which may have a substituent. More preferably, a spacer which is a straight chain, branched chain, cyclic chain or aromatic hydrocarbon chain having 1 to 40 carbon atoms is preferred.

  In the gel composition of the present invention, the hydrophilic group of the multi-chain polyhydrophilic group type compound is preferably each independently a carboxyl group, a sulfonic acid group, a sulfate ester group, a phosphate ester group and / or a salt thereof. Here, examples of the salt include alkali metal salts, alkaline earth metal salts, ammonium salts, organic amine salts, basic amino acid salts, and the like, specifically, alkali metals such as sodium, potassium, lithium, calcium, 1 selected arbitrarily from alkaline earth metals such as magnesium, metals such as aluminum and zinc, organic amines such as ammonia, monoethanolamine, diethanolamine, triethanolamine and triisopropanolamine, basic amino acids such as arginine and lysine A salt with a seed or two or more. Among these, sodium salts, potassium salts, organic amine salts, and basic amino acid salts are particularly preferable.

In the gel composition of the present invention, at least one of the multi-chain polyhydrophilic group-type compounds is a surfactant having an amino acid residue in the molecule. It is preferable from the viewpoint of hypoallergenicity when used. Furthermore, it is more preferable that at least one of the multi-chain polyhydrophilic group type compounds is a compound represented by the above general formula (1).
In the general formula (1), the long-chain acyl group represented by R ¹ CO may be independent, that is, each may be different or the same, and as described above, a saturated or unsaturated fatty acid having 8 to 20 carbon atoms. Any material can be used as long as it is derived from the straight chain, branched or cyclic. Further, R ¹ CO in the molecule are the same is preferably be viewed such as the reaction conditions.

In the general formula (1), R ² is hydrogen, or the number of carbon atoms that may be substituted by a hydroxyl group or a carboxyl group, a sulfonic acid group, a sulfate ester group, a phosphate ester group, or a salt thereof. 1 to 3 lower alkyl groups, for example, methyl group, ethyl group, propyl group, isopropyl group, hydroxymethyl group, hydroxyethyl group, hydroxy (iso) propyl group, dihydroxy (iso) propyl group, carboxymethyl group, A carboxyethyl group, a carboxypropyl group, a sulfoethyl group, etc. are mentioned.
In the general formula (1), n substituents attached to X (the general formula (2)) may be independent, that is, may be different or the same. Moreover, the said General formula (2) shows what the so-called acidic amino acid was N-acylated, and it does not ask | require whether they are optical isomers, for example, D-form, L-form, and a racemate.

  The acidic amino acid is a monoaminodicarboxylic acid having 2 and 1 carboxyl groups and 1 amino group, respectively, in the molecule, and the amino group may be an N-methyl group or an N-ethyl group. It does not matter whether it is an optical isomer, for example, a D-form, an L-form, or a racemate. Examples of acidic amino acids include glutamic acid, aspartic acid, lanthionine, β-methyllanthionine, cystathionine, diencholic acid, ferrinin, aminomalonic acid, β-oxyaspartic acid, α-amino-α-methylsuccinic acid, β-oxyglutamic acid. , Γ-oxyglutamic acid, γ-methylglutamic acid, γ-methyleneglutamic acid, γ-methyl-γ-oxyglutamic acid, α-aminoadipic acid, α-amino-γ-oxyadipic acid, α-aminopimelic acid, α-amino- Examples thereof include γ-oxypimelic acid, β-aminopimelic acid, α-aminosuberic acid, α-aminosebacic acid, pantothenic acid and the like.

The n substituents (the above general formula (2)) attached to X are preferable because the acidic amino acid is an L-acidic amino acid molecule because it is excellent in biodegradability. Among these, it is preferable that the substituents are the same.
In the above general formula (1), n Z attached to X are m functional groups (hydroxyl group, amino group, thiol group) substituted with X (m ≧ n and an integer of 2 to 20). It is the bond part (-O-, -NR < ³ >-, -S-) which originates, and each may be independent, that is, may be the same or different. Here, R ³ is hydrogen, or an alkyl group, alkenyl group, aryl group or alkylaryl group having 1 to 10 carbon atoms.

In the general formula (1), X is a linear, branched or cyclic chain having a molecular weight of 1 million or less and having m functional groups consisting of one or more selected from a hydroxyl group, an amino group and a thiol group. Or it is a spacer which is an aromatic hydrocarbon chain | strand, and X may have substituents other than the said hydroxyl group, an amino group, and a thiol group.
In the general formula (1), X is preferably a residue of an m-valent compound having a molecular weight of 1 million or less and having m functional groups of one kind or two or more kinds selected from a hydroxyl group, an amino group and a thiol group. And a compound residue that may have a substituent other than a hydroxyl group, an amino group, and a thiol group. Here, the m-valent compound means that a bond derived from m functional groups can be formed. It does not matter whether they are optical isomers such as D-form, L-form, and racemate.

Examples of such m-valent compounds include amino acids such as serine, threonine, cysteine, cystine, cystine disulfoxide, cystathionine, methionine, arginine, lysine, tyrosine, histidine, tryptophan, and oxyproline;
Aminoethanol, aminopropanol, aminobutanol, aminopentanol, aminohexanol, aminopropanediol, aminoethylethanolamine, aminoethylaminoethanol, aminocresol, aminonaphthol, aminonaphtholsulfonic acid,

Compounds having an amino group and a hydroxyl group in the molecule, such as aminohydroxybenzoic acid, aminohydroxybutanoic acid, aminophenol, aminophenethyl alcohol, glucosamine;
Compounds having a thiol group and a hydroxyl group in the molecule such as mercaptoethanol, mercaptophenol, mercaptopropanediol, glucothiose;
And compounds having a thiol group and an amino group in the molecule such as aminothiophenol and aminotriazole thiol. Further, proteins, peptides, etc., or those obtained by hydrolyzing them may be used.

X preferably has 1 to 40 carbon atoms among the residues of such compounds, more preferably X has 1 to 20 carbon atoms. Particularly preferred are those having 1 to 10 carbon atoms. Furthermore, X is a substituent other than a hydroxyl group, amino group, or thiol group in the molecule, and at least one or more independent carboxyl groups, sulfonic acid groups, sulfate ester groups, phosphate ester groups, or salts thereof, etc. When it contains, the multi-chain polyhydrophilic group type compound represented by the general formula (1) is preferable in that it has excellent solubility in weak acidity. X is preferably a naturally occurring type from the viewpoint of excellent biodegradability.
In the general formula (1), X is preferably an m-valent (m ≧ n) polyhydroxyl compound residue having a molecular weight of 1,000,000 or less, which may have a substituent other than a hydroxyl group. Here, the m-valent polyhydroxyl compound means that m ester bonds can be formed. It does not matter whether they are optical isomers such as D-form, L-form, and racemate.

Examples of such m-valent polyhydroxyl compounds include ethylene glycol, 1,2-propanediol, 1,3-propanediol, 1,2-butanediol, 1,3-butanediol, and 1,4-butanediol. , Pentanediol, 1,6-hexanediol, cyclohexanediol, dimethylolcyclohexane, neopentyl glycol, 1,8-octanediol,
2,2,4-trimethyl-1,3-pentanediol, isoprene glycol, 3-methyl-1,5-pentanediol, sorbite, catechol, resorcin, hydroquinone, bisphenol A, bisphenol F, hydrogenated bisphenol A, hydrogenated Bisphenol F,

Dimerdiol, dimethylolpropionic acid, dimethylolbutanoic acid, tartaric acid, dihydroxytartaric acid, mevalonic acid, 3,4-dihydroxycinnamic acid, 3,4-dihydroxyhydrocinnamic acid, hydroxybenzoic acid, dihydroxystearic acid, dihydroxyphenylalanine And divalent hydroxyl compounds such as each of these isomers;
Glycerin, trioxyisobutane, 1,2,3-butanetriol, 1,2,3-pentanetriol, 2-methyl-1,2,3-propanetriol, 2-methyl-2,3,4-butanetriol, 2-ethyl-1,2,3-butanetriol, 2,3,4-pentanetriol,

2,3,4-hexanetriol, 4-propyl-3,4,5-heptanetriol,
2,4-dimethyl-2,3,4-pentanetriol, 1,2,4-butanetriol, 1,2,4-pentanetriol, trimethylolethane, trimethylolpropane, diethanolamine, triethanolamine, trihydroxystearin Trivalent polyhydroxyl compounds such as acids;
Pentaerythritol, erythritol, 1,2,3,4-pentanetetrol, 2,3,4,5-hexanetetrol, 1,2,4,5-pentanetetrol, 1,3,4,5-hexane Tetravalent polyhydroxyl compounds such as tetrol, diglycerin and sorbitan;

Pentavalent polyhydroxyl compounds such as adonitol, arabitol, xylitol, triglycerin;
Hexavalent polyhydroxyl compounds such as dipentaerythritol, sorbitol, mannitol, iditol, inositol, dulcitol, talose, allose;
Or these dehydration condensates, polyglycerol, etc. are mentioned.

Sugars such as tetroses such as erythrose, sreose, erythrulose;
Pentose such as ribose, arabinose, xylose, lyxose, xylulose, ribulose; monosaccharides such as hexose such as allose, altrose, glucose, mannose, guylose, idose, galactose, talose, fructose, sorbose, psicose, tagatose;
Examples thereof include oligosaccharides such as maltose, isomaltose, cellobiose, gentiobiose, melibiose, lactose, tulanose, trehalose, saccharose, mannitolose, cellotriose, gentianose, raffinose, meletitose, cellotetorose, stachyose and the like.

In addition, other saccharides such as heptose, deoxy sugar, amino sugar, thio sugar, seleno sugar, aldone sugar, uronic acid, sugar acid, ketoaldonic acid, anhydro sugar, unsaturated sugar, sugar ester, sugar ether, glycoside, etc. It may be a group, and may be a polysaccharide such as starch, glycogen, cellulose, chitin, chitosan or the like, or a hydrolyzed product thereof.
X preferably has 1 to 40 carbon atoms among the residues of such compounds, and more preferably X has 1 to 20 carbon atoms. Particularly preferred are those having 1 to 10 carbon atoms.

Furthermore, when X contains at least one or more independent carboxyl group, sulfonic acid group, sulfuric acid ester group, phosphoric acid ester group or a salt thereof as a substituent, it is represented by the general formula (1). The multi-chain polyhydrophilic group-type surfactant is preferable from the viewpoint of excellent solubility in weak acidity. X is preferably a naturally occurring type from the viewpoint of excellent biodegradability.
In the general formula (1), X is preferably an m-valent polyamino compound residue having a molecular weight of 1,000,000 or less, which may have a substituent other than an amino group. Here, the m-valent polyamino compound means that m acid amide bonds can be formed. It does not matter whether they are optical isomers such as D-form, L-form, and racemate.

Examples of such m-valent polyamino compounds include N, N′-dimethylhydrazine, ethylenediamine, N, N′-dimethylethylenediamine, diaminopropane, diaminobutane, diaminopentane, diaminohexane, diaminoheptane, diaminooctane, diaminononane, Aliphatic diamines such as diaminodecane, diaminododecane, diaminoadipic acid, diaminopropanoic acid, diaminobutanoic acid and their isomers;
Diethylenetriamine, triaminohexane, triaminododecane, 1,8-diamino-4-aminomethyl-octane, 2,6-diaminocapric acid-2-aminoethyl ester, 1,3,6-triaminohexane, 1,6 , 11-triaminoundecane, aliphatic triamines such as di (aminoethyl) amine and isomers thereof;

Alicyclic polyamines such as diaminocyclobutane, diaminocyclohexane, 3-aminomethyl-3,5,5-trimethylcyclohexylamine, triaminocyclohexane;
Aromatic polyamines such as diaminobenzene, diaminotoluene, diaminobenzoic acid, diaminoanthraquinone, diaminobenzenesulfonic acid, diaminobenzoic acid, and their respective isomers;
Araliphatic polyamines such as diaminoxylene, di (aminomethyl) benzene, di (aminomethyl) pyridine, di (aminomethyl) naphthalene, and their isomers;
And polyamines substituted with hydroxyl groups such as diaminohydroxypropane and isomers thereof.

X preferably has 1 to 40 carbon atoms among the residues of such compounds, and more preferably X has 1 to 20 carbon atoms. Particularly preferred are those having 1 to 10 carbon atoms.
Furthermore, when X contains at least one or more independent carboxyl group, sulfonic acid group, sulfuric ester group, phosphoric ester group or a salt thereof as a substituent, it is represented by the general formula (1). A polychain polyhydrophilic group-type compound is preferable in that it has excellent solubility in weak acidity. X is preferably a naturally occurring type from the viewpoint of excellent biodegradability.
In the general formula (1), X is preferably an m-valent polythiol compound residue having a molecular weight of 1,000,000 or less, which may have a substituent other than a thiol group. Here, the m-valent polythiol compound means that m thioester bonds can be formed. It does not matter whether they are optical isomers such as D-form, L-form, and racemate.

Examples of such m-valent polythiol compounds include dithiol compounds such as dithioethylene glycol, dithioerythritol, and dithiothreitol. X preferably has 1 to 40 carbon atoms among the residues of such compounds, more preferably X has 1 to 20 carbon atoms. Particularly preferred are those having 1 to 10 carbon atoms.
Further, when X contains 1 to 10 independent carboxyl groups, sulfonic acid groups, sulfuric acid ester groups, phosphoric acid ester groups or salts thereof as a substituent, it is represented by the above general formula (1). A polychain polyhydrophilic group-type compound is preferable in that it has excellent solubility in weak acidity. X is preferably a naturally occurring type from the viewpoint of excellent biodegradability.

In the general formula (2), a carboxyl group represented by Y, a sulfonic acid group, a sulfuric ester group, a phosphoric ester group, and a carboxyl group, a sulfonic acid group, a sulfuric ester group, a phosphoric ester group, etc. that can be contained in X Can form salts with various basic substances.
Examples of such salts include alkali metal salts, alkaline earth metal salts, ammonium salts, organic amine salts, basic amino acid salts, and the like. Specifically, alkali metals such as sodium, potassium and lithium, calcium and magnesium 1 type arbitrarily selected from alkaline earth metals such as aluminum, metals such as aluminum and zinc, organic amines such as ammonia, monoethanolamine, diethanolamine, triethanolamine and triisopropanolamine, and basic amino acids such as arginine and lysine Or it is a salt with 2 or more types. Among these, sodium salt, potassium salt, organic amine salt, and basic amino acid salt are preferable.

  As a method for producing such a multi-chain polyhydrophilic group compound represented by the general formula (1), an N-long chain acyl acidic amino acid anhydride represented by the following general formula (3) and a hydroxyl group in the molecule, It can be obtained by reacting a compound having one or two or more m functional groups selected from an amino group and a thiol group in water and / or a mixed solvent of water and an organic solvent.

  Alternatively, the multi-chain polyhydrophilic group compound represented by the general formula (1) is an N-long chain acyl acidic amino acid anhydride represented by the general formula (3) and a polyhydroxyl compound, a polyamino compound, or a polythiol compound, or A compound having any two or three of hydroxyl group, amino group, and thiol group in the molecule at a temperature higher than any melting point, or tetrahydrofuran, benzene, toluene, xylene, carbon tetrachloride, chloroform, acetone It can obtain by mixing at -5-200 degreeC using inert solvents, such as.

  Alternatively, the multi-chain polyhydrophilic group type compound represented by the general formula (1) is an N-long chain acyl acidic amino acid mono-lower ester (eg, methyl ester, ethyl ester) and a polyhydroxyl compound, a polyamino compound, or a polythiol compound, Alternatively, a compound having any two or three of hydroxyl group, amino group, and thiol group in the molecule is dissolved in a suitable solvent such as dimethylformamide, a catalyst such as potassium carbonate is added, and- It can be obtained by carrying out a heating reaction at 5 ° C. to 250 ° C. and then removing the reaction solvent. Alternatively, the surfactant of the present invention can be obtained by heat-melting without solvent, adding a catalyst such as sodium hydroxide, and performing a transesterification reaction at room temperature to 250 ° C.

  In the gel composition of the present invention, as the surfactant, in addition to the polychain polyhydrophilic group type compound, other surfactants can be included as long as the object of the present invention is not impaired. Examples of such surfactants include anionic surfactants, nonionic surfactants, cationic surfactants, and amphoteric surfactants having a structure having one long-chain hydrophobic group and / or one hydrophilic group in the molecule. Etc. Among them, those containing an N-long chain acylamino acid type surfactant or an acyl peptide type surfactant as an anionic surfactant in the aqueous solution are preferable.

  The N-long chain acylamino acid herein is one in which an acyl group derived from a saturated or unsaturated fatty acid having 8 to 20 carbon atoms is introduced into the amino group of the amino acid. The amino acid residues in N-long chain acylamino acids are various amino acids such as α-amino acid, β-amino acid, γ-amino acid and ω-amino acid, and the amino group may be N-methyl or N-ethyl. Absent. It does not matter whether it is an optical isomer, that is, D-form, L-form, or racemate.

For example, glutamic acid, aspartic acid, glycine, alanine, valine, leucine, isoleucine, serine, threonine, cysteine, cystine, methionine, lysine, arginine, phenylalanine, tyrosine, histidine, tryptophan, proline, oxyproline, lanthionine, β-methyllunch Onine, cystathionine, dienecholic acid, ferrinin, aminomalonic acid, β-oxyaspartic acid, α-amino-α-methylsuccinic acid, β-oxyglutamic acid, γ-oxyglutamic acid, γ-methylglutamic acid, γ-methyleneglutamic acid, γ -Methyl-γ-oxyglutamic acid, α-aminoadipic acid, α, α'-diaminoadipic acid, β, β'-diaminoadipic acid, α-amino-γ-oxyadipic acid, α-aminopimelic acid, α-amino Non-γ-oxypimelic acid, β-aminopimelic acid, α-aminosuberic acid, α-aminosebacic acid, pantothenic acid, sarcosine, taurine, methyltaurine and the like.

Any acyl group may be used as long as it is derived from a saturated or unsaturated fatty acid having 8 to 20 carbon atoms, and may be linear, branched or cyclic. From the viewpoint of biodegradability, the N-long chain acylamino acid is preferably an N-long chain acyl-L-amino acid.
The acyl peptide referred to here is obtained by hydrolyzing a protein and then acylating.

In the gel composition of the present invention, examples of the polyhydroxyl compound having two or more hydroxyl groups in the molecule include ethylene glycol, 1,2-propanediol, 1,3-propanediol, 1,2-butanediol, 1, 3-butanediol, 1,4-butanediol, pentanediol, 1,6-hexanediol, cyclohexanediol, dimethylolcyclohexane, neopentylglycol, 1,8-octanediol,
2,2,4-trimethyl-1,3-pentanediol, isoprene glycol, 3-methyl-1,5-pentanediol, sorbite, catechol, resorcin, hydroquinone, bisphenol A, bisphenol F, hydrogenated bisphenol A, hydrogenated Bisphenol F,

Dimerdiol, dimethylolpropionic acid, dimethylolbutanoic acid, tartaric acid, dihydroxytartaric acid, mevalonic acid, 3,4-dihydroxycinnamic acid, 3,4-dihydroxyhydrocinnamic acid, hydroxybenzoic acid, dihydroxystearic acid, dihydroxyphenylalanine And divalent hydroxyl compounds such as each of these isomers;
Glycerin, trioxyisobutane, 1,2,3-butanetriol, 1,2,3-pentanetriol, 2-methyl-1,2,3-propanetriol, 2-methyl-2,3,4-butanetriol, 2-ethyl-1,2,3-butanetriol, 2,3,4-pentanetriol,

2,3,4-hexanetriol, 4-propyl-3,4,5-heptanetriol, 2,4-dimethyl-2,3,4-pentanetriol, 1,2,4-butanetriol, 1,2, Trivalent polyhydroxyl compounds such as 4-pentanetriol, trimethylolethane, trimethylolpropane, diethanolamine, triethanolamine, trihydroxystearic acid;
Pentaerythritol, erythritol, 1,2,3,4-pentanetetrol, 2,3,4,5-hexanetetrol, 1,2,4,5-pentanetetrol, 1,3,4,5-hexane Tetravalent polyhydroxyl compounds such as tetrol, diglycerin and sorbitan;

Pentavalent polyhydroxyl compounds such as adonitol, arabitol, xylitol, triglycerin;
Hexavalent polyhydroxyl compounds such as dipentaerythritol, sorbitol, mannitol, iditol, inositol, dulcitol, talose, allose;
Or these dehydration condensates, polyglycerol, etc. are mentioned.

Sugars such as tetroses such as erythrose, sreose, erythrulose;
Pentose such as ribose, arabinose, xylose, lyxose, xylulose, ribulose; monosaccharides such as hexose such as allose, altrose, glucose, mannose, guylose, idose, galactose, talose, fructose, sorbose, psicose, tagatose;
Examples thereof include oligosaccharides such as maltose, isomaltose, cellobiose, gentiobiose, melibiose, lactose, tulanose, trehalose, saccharose, mannitolose, cellotriose, gentianose, raffinose, meletitose, cellotetorose, stachyose and the like.

  In addition, other saccharides such as heptose, deoxy sugar, amino sugar, thio sugar, seleno sugar, aldone sugar, uronic acid, sugar acid, ketoaldonic acid, anhydro sugar, unsaturated sugar, sugar ester, sugar ether, glycoside, etc. It may be a group, and may be a polysaccharide such as starch, glycogen, cellulose, chitin, chitosan or the like, or a hydrolyzed product thereof. Two or more of these polyhydroxyl compounds may be used in combination. The polyhydroxyl compound is preferably a trihydroxy or higher polyhydroxyl compound.

In the gel composition of the present invention, as the oily component, either liquid oil or solid fat can be used, and it may be an oily component commonly used as a component for cosmetics, external medicines and the like.
For example, avocado oil, almond oil, olive oil, cacao oil, sesame oil, safflower oil, soybean oil, camellia oil, persic oil, castor oil, grape seed oil, macadamia nut oil, mink oil, cottonseed oil, owl, coconut oil, egg yolk oil, Fats and oils such as palm oil, palm kernel oil, glyceryl triisooctanoate, glyceryl tri-2-ethylhexanoate cholesterol fatty acid ester,
Waxes such as whale wax, carnauba wax, candelilla wax, jojoba oil, beeswax, lanolin and their derivatives,

Hydrocarbons such as liquid paraffin, paraffin, petrolatum, ceresin, microcrystalline wax, squalane, squalene,
Higher fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, oleic acid, behenic acid, undecylenic acid, lanolin fatty acid, hard lanolin fatty acid, soft lanolin fatty acid acid,
Higher alcohols such as lauryl alcohol, cetyl alcohol, cetostearyl alcohol, stearyl alcohol, isostearyl alcohol, 2-octyldodecanol, oleyl alcohol, behenyl alcohol, lanolin alcohol, hydrogenated lanolin alcohol, hexyldecanol,

Higher alcohol fatty acid esters such as isopyropyl myristate, octadecyl myristate, 2-octyldodecyl myristate, cetyl 2-ethylhexanoate, diisostearyl malate, isostearyl isostearate, isostearyl cholesteryl ester, butyl stearate,
Examples include volatile and nonvolatile oily components such as silicone oils such as methylpolysiloxane and methylphenylpolysiloxane. Two or more of these oil components may be used in combination.

The gel composition of the present invention comprises one or more multi-chain polyhydrophilic group compounds, one or more polyhydroxyl compounds having two or more hydroxyl groups in the molecule, and one or more oily components. A gel composition containing at least one neutralization degree adjusting agent selected from the group consisting of two or more organic acids, inorganic acids, organic bases and inorganic bases, wherein the water content in the composition is 50% by weight And the composition in the composition is 1) the total amount of the polychain polyhydrophilic group type compound is 0.1 to 40% by weight, 2) the total amount of the polyhydroxyl compound is 1 to 60% by weight, and 3) The total amount of the oil component is 1 to 95% by weight, 4) The total amount of at least one neutralization degree adjusting agent selected from the group consisting of organic acids, inorganic acids, organic bases and inorganic bases is 0 to 10% by weight ( However, the total of the components 1) to 4) is 100% by weight. Is preferred. Here, the total amount of each of the multi-chain polyhydrophilic group type compound, the polyhydroxyl compound, the oily component, and the neutralization degree adjuster is the sum of the corresponding components. Even if the composition of each component is outside this range, it may become a gel-like dosage form, but when applied to the skin, etc., the elongation will deteriorate, the oily component will separate and poor stability, gel formation Depending on the purpose, the feeling of use may be unfavorable, depending on the purpose, such as a decrease in dirt cleaning power or poor elongation.

  In the gel composition of the present invention, the composition of each of the multi-chain polyhydrophilic group compound, polyhydroxyl compound, oil component, and neutralization degree modifier is preferably 1) multi-chain. The total amount of the polyhydrophilic group type compound is 1 to 25% by weight, 2) the total amount of the polyhydroxyl compound is 5 to 40% by weight, 3) the total amount of the oily component is 20 to 80% by weight, and 4) the total amount of the neutralization degree adjusting agent. Is 0 to 5% by weight. More preferably, 1) the total amount of the multi-chain polyhydrophilic group type compound is 3 to 15% by weight, 2) the total amount of the polyhydroxyl compound is 5 to 30% by weight, 3) the total amount of the oily component is 30 to 70% by weight, 4 ) The total amount of the neutralization degree adjusting agent is 0 to 2% by weight.

In the gel composition of the present invention, the water content is preferably 50% by weight or less. Outside this range, it may be difficult to stably maintain the gel state. The water content is more preferably 30% by weight or less. More preferably, it is 20% by weight or less.
In the gel composition of the present invention, in order to obtain a gel composition having a transparent appearance, it comprises a multi-chain polyhydrophilic group compound, a polyhydroxyl compound, an organic acid, an inorganic acid, an organic base, and an inorganic base in the composition. It is preferable that the difference in refractive index at 20 ° C. between an aqueous phase composed of at least one neutralization degree adjusting agent selected from the group and water and an oil phase composed of an oil component is ± 0.05 or less. If the difference in refractive index between the two phases is outside this range, it is difficult to obtain a transparent composition having an appearance, and the difference in refractive index between the two phases is preferably close to zero. More preferably, the difference in refractive index between both phases is set to ± 0.03 or less. More preferably, the refractive index difference between both phases is set to ± 0.01 or less.

  In order to produce the gel composition of the present invention, at least one neutralization selected from the group consisting of a multi-chain polyhydrophilic group compound, a polyhydroxyl compound, an oil component, an organic acid, an inorganic acid, an organic base, and an inorganic base. It is manufactured by stirring and mixing the degree-adjusting agent and sometimes water under high cutting force. As a preferable production method, a method in which components other than the oil component are sufficiently stirred and mixed and the oil component is added thereto is preferable.

The characteristics of the gel composition of the present invention thus obtained are as follows:
1) It is particularly excellent in elongation when applied to the skin, etc., and when dispersed after application, it is very easily dispersed finely into an emulsion state. 2) It has a high gel-forming ability and keeps a very stable gel over time. 3) It has a feature that it is easy to adjust the degree of neutralization with respect to the acid value of the contained multi-chain polyhydrophilic group-type compound, and solves the problems so far.

The gel composition of the present invention is widely applied to, for example, household cleaners (clothing, kitchen, dwelling, tableware, contact lenses, etc.), detergents, cosmetics, foods, pharmaceuticals, etc., from compositions that come into contact with humans, industrial cleaners, etc. can do.
The gel composition of the present invention can be used in various forms depending on the purpose such as liquid, solid, gel, paste, slurry, mist, liquid crystal, powder, aerosol and the like. However, it is not limited to this form.

The cosmetic product in the present invention is a generic name for quasi-drugs and cosmetics referred to in the Pharmaceutical Affairs Law. Specifically, quasi-drugs include mouth fresheners, odor control agents, tempered powders, hair nourishing agents, List hair removal agents, hair dyes, permanent wave agents, bath agents, medicated cosmetics, medicated toothpastes, etc.
Cosmetics include cosmetic soap, face wash (cream / paste, liquid / gel, granule / powder, aerosol, etc.), shampoo, rinse, etc.

Hair dyes, hair treatments (including cream, mist, oil, gel and other forms and split hair coats), hair set (hair oil, set lotion, curler lotion, pomade, tics, bottles Cosmetics for hair, such as oiling, hair spray, hair mist, hair liquid, hair foam, hair gel, water grease);
General cream, milky lotion (cleansing cream, cold cream, burnishing cream, hand cream, etc.), shaving cream (after shaving cream, shaving cream, etc.), lotion (hand lotion, general lotion, etc.), cologne, shaving Basic cosmetics such as lotions (after shaving lotions, shaving lotions, etc.), cosmetic oils, packs;

Oshiroi (Cream Occasion, Solid Oroze, Powder Ooiro, Talcum Powder, Kneading Oro, Baby Powder, Body Powder, Water Osoiro, etc.), Powder, Foundation (Cream, Liquid, Solid etc.), Blusher, Eyebrows, Eye Cream, Eye Makeup cosmetics such as shadow mascara;
Perfumes such as general perfume, kneaded perfume, powdered perfume; fragrance, deodorant, deodorant such as gel type, liquid type, ceramic type;

Sunscreen / sunscreen cosmetics such as sunscreen / sunscreen cream, sunscreen / sunscreen lotion, sunscreen / sunscreen oil;
Nail cosmetics such as nail cream, enamel, enamel remover;
Eyeliner cosmetics;
Lip cosmetics such as lipstick and lip balm;
Oral cosmetics such as toothpaste;
Listed are bath cosmetics such as bath salt, bath oil, and bubble bath.

Moreover, in the gel composition of this invention, unless the objective of this invention is impaired, it can use together with various base materials according to a use and the objective.
Specifically, natural rubbers such as gum arabic and tragacanth, glucosides such as saponin, cellulose derivatives such as methylcellulose, carboxycellulose, and hydroxymethylcellulose, natural polymers such as lignin sulfonate and shellac, polyacrylates, Styrene-acrylic acid copolymer salt, vinyl naphthalene-maleic acid copolymer salt, β-naphthalene sulfonic acid formalin condensate sodium salt, anionic polymer such as phosphate, polyvinyl alcohol, polyvinyl pyrrolidone, Dispersants such as nonionic polymers such as polyethylene glycol;

A higher fatty acid salt (soap); a higher fatty acid having 8 to 20 carbon atoms in the hydrophobic group or a salt thereof;
N-acyl amino acid type anionic surfactant; examples of the acyl group include those having 8 to 20 carbon atoms as described above, and examples of the constituent amino acids include the above-mentioned acidic amino acids such as glutamic acid and aspartic acid, or Glycine, alanine, valine, leucine, isoleucine, proline, methionine, cysteine, tryptophan, tyrosine, phenylalanine, asparagine, glutamine, serine, threonine, oxyproline, β-aminopropionic acid, γ-aminobutyric acid, anthranilic acid, m-amino Amino acids such as benzoic acid, p-aminobenzoic acid, etc .; alkyl ether carboxylates, amide ether carboxylates, etc., alkyl sulfate esters (AS), polyoxyethylene alkyl ether sulfates (AES), alkyl ether sulfates Acid salt, sulfate of higher fatty acid ester, sulfate of higher fatty acid alkylolamide, sulfated oil, polyoxyethylene styrenated phenyl ether sulfate, alpha-olefin sulfonate (AOS), alkylbenzene sulfonate, alkylnaphthalene Sulfonates, alkyl sulfonates (SAS), dialkyl sulfosuccinates, alpha-sulfonated fatty acid salts, alkane sulfonates, sulfonates of higher fatty acid esters, alpha-sulfonated fatty acid salts, sulfonates of higher fatty acid amides, N-acyl-N-alkyl taurate, N-acyl-N-methyl taurate, alkyl phosphate, alkyl ether phosphate, polyoxyethylene alkyl ether phosphate, polyoxyethylene alkyl phenyl ether phosphate, Naphtha Anionic surfactants such as Nsurufon formalin condensate;

Amphoteric surfactants such as alkylbetaines, alkylamidobetaines, alkylsulfobetaines, imidazolinium betaines, lecithins;
Polyoxyethylene alkyl ether (AE), polyoxyethylene alkyl phenyl ether, polyoxyethylene polystyryl phenyl ether, polyoxyethylene polyoxypropylene glycol, polyoxyethylene polyoxypropylene alkyl ether, polyoxyalkylene fatty acid ester, polyoxyalkylene Sorbitan fatty acid ester, polyoxyalkylene fatty acid alkanolamide, polyoxyalkylene alkyl glucoside, polyoxyalkylene hydrogenated castor oil, polyoxyalkylene alkyl amine, polyoxyalkylene alkyl phenyl ether, and other ethylene oxide condensation types,

Polyhydric alcohol fatty acid partial ester, polyoxyethylene polyhydric alcohol fatty acid partial ester, polyoxyethylene fatty acid ester, (poly) glycerin fatty acid ester, polyoxyethylene hydrogenated castor oil, polyoxyethylene alkylamine, triethanolamine fatty acid partial ester, alkyl Nonionic surfactants such as polyglucoside, propylene glycol fatty acid ester, sorbitan fatty acid ester, polyhydric alcohol ester such as sho, fatty acid ester; fatty acid alkanolamide, sugar amine acylated product, triethanolamine fatty acid partial ester, fatty acid alkylolamide , Alkylamine oxide,
Etc.

Primary to tertiary fatty amine salts, alkylammonium chloride salts, tetraalkylammonium salts, trialkylbenzylammonium salts, alkylpyridinium salts, alkylhydroxyethylimidazolinium salts, dialkylmorpholinium salts, alkylisoquinolium salts, Cationic surfactants such as benzethonium salts and benzalkonium salts;
Polymeric surfactants such as sodium alginate, starch derivatives, tragacanth gum;
Natural surfactants such as lecithin, lanolin, cholesterol, saponin;

Avocado oil, almond oil, olive oil, cacao oil, sesame oil, safflower oil, soybean oil, camellia oil, persic oil, castor oil, mink oil, cottonseed oil, owl, palm oil, egg yolk oil, palm oil, palm kernel oil, synthetic triglyceride, Fats and oils such as jojoba oil;
Hydrocarbons such as liquid paraffin, petrolatum, ceresin, microcrystalline wax, isoparaffin;
Waxes such as beeswax, whale wax, lanolin, carnauba wax, candelilla wax and derivatives thereof;
Higher fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, oleic acid, behenic acid, undecylenic acid, lanolin fatty acid, hard lanolin fatty acid, soft lanolin fatty acid;

Higher alcohols such as lauryl alcohol, cetanol, cetostearyl alcohol, stearyl alcohol, oleyl alcohol, behenyl alcohol, lanolin alcohol, hydrogenated lanolin alcohol, hexyldecanol, octyldodecanol;
Other ester oils such as isopropyl myristate and butyl stearate;
Metal soap, dimethylpolysiloxane, polyether-modified silicone, alcohol-modified silicone, methylphenylpolysiloxane, epoxy-modified silicone, fluorine-modified silicone, alkyl-modified silicone, alkoxy-modified silicone, amino-modified silicone, volatile silicone and other silicones Volatile and non-volatile oils;

Polyols such as glycerin, diglycerin, polyglycerin, 1,3-butanediol, propanediol, polyethylene glycol;
Moisturizers such as trimethylglycine, sorbitol, raffinose, pyrrolidone carboxylates, lactates, hyaluronates, ceramides;
Hydroxyethylcellulose, carboxymethylcellulose, hydroxyethylcellulose hydroxypropyltrimethylammonium chloride ether, methylcellulose, ethylcellulose, hydroxypropylcellulose, methylhydroxypropylcellulose, soluble starch, carboxymethylstarch, methylstarch,

Propylene glycol alginate, polyvinyl alcohol, polyvinyl pyrrolidone, polyvinyl methyl ether, carboxyvinyl polymer, polyacrylate, guar gum, locust bin gum, quince seed, carrageenan, galactan,
Gum arabic, pectin, mannan, starch, xanthan gum, dextran, succinoglucan, curdlan, hyaluronic acid, gelatin, casein, albumin, collagen, methoxyethylene maleic anhydride copolymer, amphoteric methacrylate copolymer, polychlorinated Water-soluble and oil-soluble polymers such as dimethylmethylene piperidinium, polyacrylate copolymer, polyvinyl acetate, nitrocellulose, silicone resin;
As cationized cellulose derivatives, cationic starch, cationized guar gum derivatives, diallyl quaternary ammonium salts / acrylamide copolymers, quaternized polyvinylpyrrolidone derivatives, quaternized vinylpyrrolidone / vinylimidazole polymers, polyglycol / amines Cationic polymers such as condensates, quaternized collagen polypeptides, polyethyleneimine, cationic silicone polymers, adipic acid / dimethylaminohydroxypropyldiethylenetriamine copolymers, polyaminopolyamides, cationic chitin derivatives, quaternized polymers;

Thickening and foam increasing components such as polyethylene glycol fatty acid ester, polyoxyethylene fatty acid ester methyl glycoside, tetradecene sulfonate;
Sequestering agents such as ethylenediaminetetraacetic acid and its salts, hydroxyethylenediaminetriacetic acid and its salts, phosphoric acid, ascorbic acid, succinic acid, gluconic acid, polyphosphates, metaphosphates, hinokitiles;
Preservatives such as paraoxybenzoates, benzoic acid and its salts, phenoxyethanol, hinokitile;

PH adjusters such as citric acid, malic acid, adipic acid, glutamic acid, aspartic acid;
Other anti-dandruff and itching agents such as trichlorocarbanilide, salicylic acid, zinc pyrithione, isopropylmethylphenol;
Benzophenone derivatives, paraaminobenzoic acid derivatives, paramethoxycinnamic acid derivatives, salicylic acid derivatives and other UV absorbers;
Whitening agents such as arbutin, kojic acid, ascorbic acid, hinokitile and its derivatives;

Blood circulation promoters such as assembly extract, cephalanthin, vitamin E and its derivatives, gamma oryzanol;
Local stimulants such as pepper tincture, ginger tincture, cantharis tincture, nicotinic acid benzyl ester;
Nutrients such as various vitamins and amino acids;
Female hormone agent;
Hair root activator;

Anti-inflammatory agents such as glycyrrhetinic acid, glycyrrhizic acid derivatives, allantoin, azulene, aminocaproic acid, hydrocortisone;
Astringents such as zinc oxide, zinc sulfate, allantoin hydroxyaluminum, aluminum chloride, zinc sulfocolate, tannic acid;
Refreshing agents such as menthol and camphor;
Antihistamines;
Antioxidants such as silicone-based materials such as polymer silicone and cyclic silicone, tocopherols, BHA, BHT, gallic acid, NDGA;

  Purified water, others, oyster extract, N-methyl-L-serine, whey, nicotinamide, diisopropylamine dichloroacetic acid, mevalonic acid, γ-aminobutyric acid (including γ-amino-β-hydroxybutyric acid), altea extract, Aloe extract, apricot kernel extract, turmeric extract, oolong tea extract, dried sea water, hydrolyzed wheat powder, hydrolyzed silk, carrot extract, cucumber extract, gentian extract, yeast extract, rice germ oil, comfrey extract, savonso extract, Giant extract, lion extract, birch extract, Atlantic mint extract, assembly extract, bisabolol, propolis, loofah extract, bodaiju extract, hop extract, marronnier extract, muroji extract, melissa extract, eucalyptus extract, yukinoshita extract, rosemary Can kiss, Roman chamomile extract, royal jelly extract, seaweed, rice bran, licorice, citrus unshiu peel, angelica, pulverized Momonoha, sphingolipids, guaiazulene, may contain vitamin C, and the like.

In particular, combined use with fatty acid diethanolamide, polyoxyethylene dioleic acid methyl glucoside, polyethylene glycol distearate, tetradecene sulfonate, myristic acid salts, myristyl dimethylamine is useful in terms of increasing viscosity and foaming power. In addition, the combined use with each zwitterionic surfactant is extremely useful in that the irritation is further reduced.
Hereinafter, the present invention will be described more specifically using examples and the like, but the present invention is not limited to these examples and the like.

The evaluation means used in the examples of the present invention are as follows.
[Static friction coefficient of gel composition]
Gel composition 0.15g was applied to fully dried artificial leather, and it was rubbed back and forth 15 times at a moving width of 40mm and a moving speed of 10mm / sec. The average static friction coefficient was taken from the static friction coefficient measured at times and evaluated according to the following criteria.
○: Static friction coefficient is less than 0.5 △: 、, 0.5 or more and less than 0.6 ×: 〃, 0.6 or more

[Ease of use]
The panelists applied 0.15 g of the gel composition to the skin, and subjected the sensory evaluation to the ease of elongation of the gel composition after lightly massaging with fingers for 5 times according to the following criteria.
○: 3 or more people who felt that the growth was further reduced by massage △: 〃, 1 or 2 people ×: 〃, 0 people

[Stability]
Each gel composition was stored at 40 ° C., the state after one month was observed, and the stability was evaluated according to the following criteria.
○: Good with no change in state Δ: Slight separation is observed ×: Clear separation is observed
[appearance]
Each gel composition was visually evaluated.

[Production Example 1 of multi-chain polyhydrophilic group type compound]
9.1 g (0.05 mol) of L-lysine hydrochloride was mixed with 57 g of water. While this solution was adjusted to a pH range of 10 to 11 with a 25% aqueous sodium hydroxide solution and the reaction temperature was maintained at 5 ° C., 31.1 g of N-lauroyl-L-glutamic anhydride (0. 1 mol) was added over 2 hours to carry out the reaction. After stirring for another 30 minutes, tertiary butanol was added to a concentration of 10% by weight in the liquid, 75% sulfuric acid was added dropwise to bring the liquid pH value to 2, and the liquid temperature to 65 ° C. It was adjusted. After completion of the dropwise addition, stirring was stopped and the mixture was allowed to stand at 65 ° C. for 20 minutes, so that the organic layer and the aqueous layer were separated, and the organic layer was separated therefrom. Tertiary butanol and water were added to the separated organic layer, the temperature was raised to 65 ° C., and the mixture was stirred for 20 minutes. After the stirring was stopped, the mixture was allowed to stand to separate into an organic layer and an aqueous layer. After repeating the same washing operation with respect to the obtained organic layer, the solvent was removed from the obtained organic layer and neutralized with sodium hydroxide to a solid content of 30% by weight and a neutralization degree of 0.3 with respect to the acid value. And dried to obtain a multi-chain polyhydrophilic group type compound.

[Production Example 2 of multi-chain polyhydrophilic group type compound]
In Production Example 1, the neutralization was carried out under the same conditions as in Production Example 1 except that the solid content was 30% by weight with sodium hydroxide and the neutralization degree was 0.6 with respect to the acid value. Obtained.
[Production Example 3 of Multi-Chain Polyhydrophilic Group Type Compound]
In Production Example 1, the neutralization was carried out under the same conditions as in Production Example 1 except that the solid content was 30% by weight with sodium hydroxide and the neutralization degree with respect to the acid value was 1.2. Obtained.

[Production Example 4 of Multi-Chain Polyhydrophilic Group Type Compound]
In Production Example 1, the neutralization was carried out under the same conditions as in Production Example 1 except that the solid content was 30% by weight with potassium hydroxide and the degree of neutralization with respect to the acid value was 0.4. Obtained. [Production Example 5 for multi-chain polyhydrophilic group type compound]
In Production Example 1, the neutralization was carried out under the same conditions as in Production Example 1 except that triethanolamine was used as the neutralization condition and the solid content was 30% by weight and the degree of neutralization with respect to the acid value was 0.4. Obtained.

[Production Example 6 of multi-chain poly-hydrophilic group type compound]
In Production Example 1, the reaction was carried out under the same conditions as in Production Example 1 except that N-cocoyl-L-glutamic anhydride was used as an additive to obtain a multi-chain polyhydrophilic group type compound.
[Production Example 7 for multi-chain polyhydrophilic group type compound]
In Production Example 1, N-stearoyl-L-glutamic anhydride was used as an additive and the neutralization degree with respect to the acid value was changed to 0.8. Obtained.

[Examples 1 to 15, Comparative Example 1]
Gel compositions having the compositions shown in Table 1 were produced, and the static friction coefficient, ease of elongation during use, and stability were evaluated for each. The results are shown in Table 1.
[Method for producing gel composition]
All gel compositions were prepared by the following method.
Ingredients other than the oil component are mixed at 70 ° C. with stirring. To this, the oily component was slowly added dropwise with stirring, and the mixture was further stirred and then cooled to obtain a gel composition.

  The gel composition of the present invention is particularly excellent in usability such as easiness of elongation when applied to and rubbed against the skin or the like, and can be suitably used in the field of cosmetics such as cleansing cosmetics. Further, the preparation method is easy and useful in production.

Claims (8)

  Among the multi-chain polyhydrophilic group type compounds having two or more long-chain hydrophobic groups and hydrophilic groups in the molecule, the degree of neutralization with respect to the acid value of the multi-chain polyhydrophilic group type compound is 0.1 to 0. 1 type or 2 types or more of less than 9 types, 1 type or 2 types or more of polyhydroxyl compounds having 2 or more hydroxyl groups in the molecule, and 1 type or 2 types or more of oily components Gel composition.   With respect to the acid value of the multi-chain polyhydrophilic group-type compound by at least one neutralization degree adjusting agent selected from the group consisting of organic acids, inorganic acids, organic bases, and inorganic bases mixed and contained in the gel composition The gel composition according to claim 1, wherein the gel composition contains one or more of those having a degree of harm adjusted to 0.1 or more and less than 0.9.   The water content in the gel composition is 50% by weight or less, and the composition in the gel composition is 1) the total amount of the multi-chain polyhydrophilic group type compound is 0.1 to 40% by weight, 2) polyhydroxyl The total amount of the compound is 1 to 60% by weight, 3) The total amount of the oil component is 1 to 95% by weight, and 4) At least one neutralization degree adjustment selected from the group consisting of organic acids, inorganic acids, organic bases and inorganic bases The total amount of the agent is 0 to 10% by weight (provided that 1) to 4) are 100% by weight in total. The gel composition according to claim 1 or 2, wherein   The gel composition according to any one of claims 1 to 3, wherein at least one of the multi-chain polyhydrophilic group type compounds in the gel composition has an amino acid residue in the molecule. The gel composition according to any one of claims 1 to 4, wherein at least one of the multi-chain polyhydrophilic group compounds in the gel composition is a compound represented by the following general formula (1).

(In the above general formula (1), n Zs are bonding parts derived from m functional groups substituted with X (m ≧ n), which are independent, that is, may be the same or different, X is a spacer which is a straight chain, branched chain, cyclic chain or aromatic hydrocarbon chain having a molecular weight of 1,000,000 or less, which may have a substituent other than the functional group, and is attached to X via Z The substituents represented by the following general formula (2) are each independent, that is, they may be the same or different,
R ¹ CO represents a long-chain acyl group derived from a saturated or unsaturated fatty acid having 8 to 20 carbon atoms, R ² is hydrogen, or a carbon which may be substituted by a hydroxyl group or a carboxyl group A lower alkyl group having 1 to 3 atoms; Y represents a carboxyl group, a sulfonic acid group, a sulfate ester group, a phosphate ester group and / or a salt thereof; j and k are each independently 0, 1, 2; And j and k are not 0 at the same time, and n is an integer of 2 to 20)

  At least one of the multi-chain polyhydrophilic group type compounds in the gel composition is a compound represented by the general formula (1), and in the general formula (1), X has a substituent other than the functional group. The gel composition according to any one of claims 1 to 5, wherein the gel composition is a spacer that is a linear, branched, cyclic, or aromatic hydrocarbon chain having 1 to 40 carbon atoms. .   The gel composition according to any one of claims 1 to 6, wherein the gel composition is used as a cleansing cosmetic material that has a very light elongation when applied to the skin or the like and is rubbed.   With respect to the acid value of the multi-chain polyhydrophilic group-type compound by at least one neutralization degree adjusting agent selected from the group consisting of organic acids, inorganic acids, organic bases, and inorganic bases mixed and contained in the gel composition The method for preparing a gel composition according to any one of claims 1 to 7, wherein the degree of harm is adjusted to 0.1 or more and less than 0.9.