JP2006022056A - Agent for preventing getting drunk - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain a medicine that has hangover clearing effect and prevents or treats and ameliorates adverse effect by alcohol such as drunken sickness, hangover, etc., without side effect. <P>SOLUTION: The composition comprises a component derived from Hericium erinaceum and prevents or treats actions by drinking. Hericium erinaceum is found to have preventing or alleviating action on alcoholic action (e.g. drunken sickness, hangover, etc.). <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to a drug for preventing or reducing alcohol sickness.

  Physical fatigue, headache, and mental weakness caused by drinking are collectively referred to as sickness or hangover depending on the symptoms. Such hangovers and hangovers are the beginnings of alcohol addiction, and are especially problematic for those who are vulnerable to alcohol for modern people who are often associated with alcohol.

  Alcohol poisoning is caused by ethanol, which is said to be absorbed 20% in the stomach and 80% in the small intestine. This absorbed ethanol is transported to the liver.

  Alcohol is decomposed into acetaldehyde by the action of alcohol dehydrogenase (also called ADH). Apart from this pathway, there is also a pathway that undergoes metabolism by the microsome-ethanol oxidation system (MEOS) to become acetaldehyde. This system is said to be activated by experiencing alcohol.

  The acetaldehyde produced in this way is generally more toxic than ethanol itself, and various discomforts appear as it runs around the body.

  Acetaldehyde is decomposed into acetic acid by the action of acetaldehyde dehydrogenase type 1 and type 2, and then finally carbon dioxide and water.

  The distinction between being prone to intoxication or being strong or weak in liquor often depends on acetaldehyde dehydrogenase type 2 (hereinafter referred to as ALDH2). If ALDH2 is small or missing, acetaldehyde cannot be rapidly decomposed, and as a result, acetaldehyde tends to accumulate. It is said that many yellow people lack ALDH2, and it is said that 44% of Japanese are deficient.

  Here, “drunkenness” refers to drunkness at the time of drinking or immediately after drinking, which is assumed to be caused by ethanol or acetaldehyde. “Hangover” refers to the ingestion of the next day after drinking, the presence of acetaldehyde that could not be metabolized in the body, and thus blood catecholamines (eg, adrenal medulla hormones such as dopamine, noradrenaline, adrenaline) ) It is said that it happens when the amount increases.

  Conventionally, various drugs such as Chinese herbal medicine have been tried and developed in anticipation of the effect as an anti-angiogenic agent or an hangover agent, but no drug with excellent feeling of sickness has been reported.

  Hericium erinaceum is a medicinal mushroom widely distributed north of the northern hemisphere temperate zone. In Japan, it is named Yamabushitake because it resembles the ornament on the chest of Shinobugi (also Suzukake) worn by Yamabushi. In China, the fruiting body resembles the head of a monkey (monkey), so it is called Baotoku. It is.

  It has long been known in China that Baotoku has various medicinal properties, and it is prized as a Chinese medicine. Boiled beetle extract is also marketed in China as a treatment for chronic gastric disease.

  In recent years, in Japan, fungus bed cultivation methods using bottles and bags have been established along with the cultivation of mushrooms, and Baotoku can be cultivated using such techniques. Various substances have also been found in various research institutes for the pharmacological components possessed by Baotoku. Known pharmacological components of B. elegans include HeLa cell growth inhibitor, nerve growth factor (NGF) synthesis induction promoter, pollen tube germination inhibitor, immune function modulator, antitumor polysaccharide, and lectin (" "Mushroom Chemistry / Biochemistry", Taku Mizuno and Masami Kawai, edited (Journal of Science Publishing Center, (1992)) and "Mushroom Medicinal and Food Effects", Taku Mizuno, Hen (THECHEMICAL TIMES No.1 (1992))) . The effects include improving effects on Alzheimer's, immune diseases, gastric ulcers, indigestion, and cancer.

  Baotoku is also known as the funnel bowl or the Ueto bowl. This alias is named after the mushroom shape resembling a funnel, written by Mizuno and Kawai, “Mushroom Chemistry and Biochemistry”, Academic Publishing Center, p309, 1992) It seems that it is named because it can absorb mushrooms and absorb the mushrooms by absorbing alcohol without drinking (non-patent document 2 = co-authored by Izawa and Kawashima, “Mushroom Hunting Guidebook” “Nagaoka Shoten, p. 116, 2002).

However, Baotoku is not used with the expectation of suppressing the side effects of alcohol such as hangover after drinking and hangover.
Mizuno and H. Kawai, “Mushroom Chemistry and Biochemistry”, Society of Science Publishing Center, p309, 1992 Co-authored by Izawa and Kawashima, “Mushroom Hunting Guidebook”, Nagaoka Shoten, p. 116, 2002

  An object of the present invention is to solve the above-mentioned conventional problems, and to provide a drug for preventing or improving treatment of side effects caused by alcohol such as sickness and hangover without side effects. To do.

  The present invention has solved the above-mentioned problems by finding that Baotoku has an action capable of preventing or reducing unexpected action (eg, hangover, hangover, etc.) caused by alcohol. Accordingly, the present invention provides the following.

  In one aspect, the present invention provides a composition for preventing or treating an effect caused by drinking, which comprises a component derived from Bacon.

  In one embodiment, the component comprises fresh balm, dried balm or balm extract.

  In one embodiment, the component includes an extract of citrus extract.

  In one embodiment, the component comprises an alcohol or water extract.

  In one embodiment, the component comprises dried peanut.

  In one embodiment, the dried spinach is prepared by a cold air drying method.

  In one embodiment, the dried spinach has been dried to a moisture content of less than about 10%, more preferably to about 8%.

  In one embodiment, the dried spinach is dried at 26-30 ° C. for about 12-48 hours.

  In one embodiment, 100 mg or more of the dried spinach is included.

  In one embodiment, the dried spinach is included in 1.8 g or more.

  In a preferred embodiment, the dried dry scale is included at 5.4 g or less.

  In a preferred embodiment, 1.8 to 5.4 g of the dried potato is included.

  In a more preferred embodiment, 1.8 to 3.6 g of the dried potato is included.

  In one embodiment, the present invention further comprises a germ fermented extract.

  In one embodiment, the boiled corn is a dry potato and mixed with the embryo fermented extract in a ratio of 10: 1 to 1:10.

  In a preferred embodiment, the corn is a dried potato and is mixed with the embryo fermented extract in a ratio of 2: 1 to 1: 2.

  In one embodiment, the composition of the present invention comprises additional components selected from the group consisting of rice germ fermented extract powder, autumn turmeric powder, yogurt powder, oyster extract powder, zinc yeast, vitamin C and citric acid.

  In a preferred embodiment, the composition of the present invention further comprises all further ingredients selected from the group consisting of fermented rice germ extract powder, autumn turmeric powder, yogurt powder, oyster extract powder, zinc yeast, vitamin C and citric acid. .

  In one embodiment, the composition of the present invention further comprises an excipient.

  In one embodiment, the excipient is selected from the group consisting of lactose, sucrose esters and starch.

In a more preferred embodiment, the present invention provides:
The following composition:
Per 6 capsules (1800mg) powdered beetle (Yamabushitake) powder 100-1000mg 5.6-55.6%
Autumn turmeric powder 100-1000mg 5.6-55.6%
Rice germ ferment extract powder 200-500mg 11.1-27.8%
Yogurt powder 100-500mg 5.6-27.8%
Oyster extract powder 100-500mg 5.6-27.8%
Zinc yeast (containing 10% zinc) 50-300mg 2.8-16.7%
Vitamin C 20-100mg 1.1-5.6%
Citric acid 50-500mg 2.8-27.8%
Add a proper amount of excipients to make a total of 1800mg,
Contains active ingredients in composition ratio. Here, examples of the excipient include lactose, sucrose ester, starch and the like. Typical prescription ratios are as follows.

Per 6 capsules (1800mg) powdered botany (Yamabushitake) 252mg 14%
Autumn turmeric powder 324mg 18%
Rice germ ferment extract powder 324mg 18%
Yogurt powder 180mg 10%
Oyster extract powder 144mg 8%
Zinc yeast (containing 10% zinc) 108mg 6%
Vitamin C 36mg 2%
Citric acid 270mg 15%
Other excipients 162mg 9%.

  In one embodiment, the composition of the present invention further comprises a pharmaceutically acceptable carrier.

  In one embodiment, the composition of the present invention is provided as a food or pharmaceutical product.

  In one embodiment, the composition of the present invention is taken before, during or after drinking.

  In a preferred embodiment, the composition of the invention is taken before drinking.

  In one aspect, the present invention provides a method for preventing or treating the effects of drinking. This method includes the step of A) causing a subject to ingest a component derived from Baitoku before, during or after drinking. The component derived from Baotoku can take any form of the above embodiment.

  In a preferred embodiment, the ingestion is performed before drinking.

  In one aspect, the present invention provides a method for producing a composition for preventing or treating the effects of drinking alcohol. This method includes the steps of A) providing a peanut; and B) mixing the component derived from the peanut with other necessary components to form a composition.

  In one embodiment, the method of the present invention further comprises the step of drying the licorice.

  In one embodiment, the drying is by a cold air drying method.

  In another aspect, the present invention provides the use of beetle for producing a composition for preventing or treating the effects of drinking.

  The composition of Baotoku used in the present invention includes dried dried Baotokuku, pearl barley (Yokuinin), hub tea (Keiko), turmeric, brown rice, barley, kelp, wolfberry, wolfberry leaves, oyster leaves, tea leaves, ginkgo biloba At least one plant component and / or fungus component selected from the group consisting of leaves, tangerine peel, tochu, shiitake mushroom, reishi, agaricus (himematsutake), and maitake The plant component and / or the fungi component may be referred to as “plant component”) and a dried product.

  In one embodiment of the present invention, the dried plant component is a mixture of pearl barley, hub tea, and turmeric.

  In another embodiment of the present invention, the dried dried potato and the dried plant component are in the form of strips and are packaged in a bag from which the contents can be extracted.

  In still another embodiment of the present invention, the dried dried hoe is obtained by drying undried dried hoe in the range of 25 ° C to 30 ° C.

  Preferred embodiments of the present invention will be shown below, but those skilled in the art can appropriately implement the embodiments and the like from the description of the present invention and well-known and common techniques in the field, and the effects and effects of the present invention can be easily achieved. It should be recognized to understand.

  ADVANTAGE OF THE INVENTION According to this invention, the effect which is enhanced compared with the past and the drunk agent which reduced the side effect are provided.

  Preferred embodiments of the present invention will be shown below, but those skilled in the art can appropriately implement the embodiments and the like from the description of the present invention and well-known and common techniques in the field, and the effects and effects of the present invention can be easily achieved. It should be recognized to understand.

Used in the present invention

(Hericiumerinaceum) (hereinafter referred to as “Hakutoku”) occurs in natural hardwood dead trees and raw trees, and can be collected. Or since artificial cultivation is possible, it is also possible to utilize the artificially cultivated balm. Artificial cultivation is performed by well-known cultivation of straw trees, fungus bed cultivation using bottles or bags, and the like. The collected raw cucumbers are eaten raw as fresh cucumbers, or cut if necessary and dried. Or after drying, it is cut or cut into a suitable size. Usually, the size after drying is 3.5 cm × 3.5 cm × 1.5 cm or less, preferably 0.5 cm × 0.5 cm × 0.2 cm to 3.5 cm × 3.5 cm × 1.5 cm, more preferably 0 Shredded to be 0.7 cm × 0.7 cm × 0.3 cm to 1.5 cm × 1.5 cm × 0.7 cm. For example, a raw boiled corn is cut into a size of 1.5 cm × 1.5 cm × 0.5 cm and dried. In addition to the above-mentioned size, for example, it is also possible to pulverize dried boiled powder into powder. Thus, by making it into a powder form, extraction time can be shortened. As a drying method, any ordinary drying method can be employed. Preferred drying conditions are low temperature of 40 ° C. or lower, more preferably 20 ° C. to 35 ° C., most preferably 25 ° C. to 30 ° C. or atmospheric pressure drying in the temperature range of 26 ° C. to 30 ° C. By selecting such a drying condition, it can dry without missing a volatile active ingredient. Lyophilization has the advantage of not changing the active ingredient, but the active ingredient may volatilize and be lost. The water content of the dried potato is usually 5 to 15% by weight, more preferably 8 to 12% by weight, and most preferably about 8 to 10% by weight.

  In the present specification, the term “component derived from citrus” refers to a component obtained directly or indirectly from citrus. In the present invention, as a component derived from Baitoku, a component having an effect of drunkness derived from Baitoku is provided in the present invention, such as fresh Baitaku, dried Baituku, Baotoku extract (water or alcohol (ethanol) extract, etc.), etc. It is understood that can be used.

  In the present specification, “fresh sea cucumber” refers to an arbitrary sea cucumber obtained from the cultivation state. As long as it is marketed as a fresh food, any boiled corn can be used.

  In the present specification, the term “dried balm” refers to any balm with reduced water content. The dried spinach can be prepared using any drying method, and any ordinary drying method can be adopted as the drying method. Preferred drying conditions are low temperature of 40 ° C. or lower, more preferably 20 ° C. to 35 ° C., most preferably 25 ° C. to 30 ° C. or normal pressure drying in the temperature range of 26 ° C. to 30 ° C., but are not limited thereto. When dry peanut is used in the present invention, the dry peanut is usually at least 100 mg, typically at least 300 mg, preferably at least 0.6 g, at least 0.9 g, at least 1.0 g, at least 1. 2g, at least 1.5g, at least 1.8g, more preferably at least 2.0g, at least 2.1g, at least 2.4g, at least 2.7g, at least 3.0g, at least 2.2g, at least 3.6g It is advantageous to include. This is because the effect of drunkness is more exhibited. In the case of using dried peanuts in the present invention, this dried peanut may be used in any amount, as long as there are no unacceptable side effects in the composition, preferably 9.0 g or less, more preferably Is advantageously used at 7.2 g or less, more preferably 5.4 g or less, but is not limited thereto. This is because if you take a large amount, side effects such as diarrhea, discomfort, and loose stool may occur.

  In the present specification, the “bottom extract” refers to a component extracted from a spinach using an arbitrary solvent (for example, water, ethanol, etc.). An extract is obtained by extracting the potato extract with usually hot water for 5 to 20 minutes or with alcohol for several hours.

  In this specification, the “cold air drying method” is a method of drying an object to be dried by exposing it to natural or dehumidified air from an air conditioner, and usually air at 20 to 40 ° C. is used.

  As used herein, “rice germ fermented extract powder” refers to any extract extracted from fermented rice germ. Examples of such fermented rice germ extract powder include those sold by Toyo Enzyme, Yonegaki Food & System Co., Ltd., “Grain Mushroom BR” and “Multice Grape”, and Yushin Shuzo Co., Ltd. Can be used, or can be prepared by the method described in US Pat. No. 1,885,507. It is said that fermented rice germ extract activates the MEOS pathway among the two pathways of alcohol degradation in the body and enhances liver function to prevent intoxication. However, a synergistic effect with other components has not been known so far. It is also known that fermented rice germ extract has an effect of suppressing prolyl endopeptidase.

  In this specification, “autumn turmeric” means “autumn turmeric” has a scientific name of turmeric (Curcuma longa), includes curcumin, and uses a root portion. If included curcumin, it can be used of any type, including commercially available products.

  As used herein, “yogurt powder” refers to a product obtained by lactic acid fermentation of milk, sheep milk, or skim milk powder to a dry powder. Yogurt is dried by freeze drying or spray drying. As a lactic acid bacterium, any known lactobacilli and lactic acid cocci can be used as long as they cause milk to undergo lactic acid fermentation. The yogurt can be used of any type, including commercially available products.

  In the present specification, the term “oyster extract powder” refers to oysters (Crassostrea nippona), oysters (Crassostrea gigas), oysters (Saccostrea cucullata), and other oysters and American oysters (Crassostrea euglena) (Ostea edulis) and other meat parts extracted and dried. The available oysters are all edible types. Contains a lot of amino acids, taurine, trace essential minerals, and zinc. If oysters products can be used of any type, including commercially available products.

  As used herein, “zinc yeast” refers to any yeast containing zinc (typically 10%). As the zinc yeast, typically, zinc yeast manufactured by Kelatron Corporation of the United States can be used, but is not limited thereto. As yeast, beer yeast (Saccharomyces cerevisiae) can be used, but is not limited thereto. As the zinc-Zn molecular weight 65.4, for example, 10% or more and 10.50% or less and the particle size of 80 mesh and 90% can be used.

  The composition of the present invention may contain a physiologically acceptable carrier, excipient or stabilizer (Japanese Pharmacopoeia 14th edition or its latest edition, Remington's Pharmaceutical Sciences, 18th Edition, AR, as necessary. Gennaro, ed., Mack Publishing Company, 1990, etc.) and a composition having the desired degree of purity can be prepared and stored in the form of a lyophilized cake or aqueous solution.

  When the present invention is used as a medicine, such medicine can be administered orally or parenterally. Alternatively, such medicaments can be administered intravenously or subcutaneously. When administered systemically, the medicament used in the present invention may be in the form of a pharmaceutically acceptable aqueous solution free of pyrogens. Such a pharmaceutically acceptable composition can be easily prepared by those skilled in the art by considering pH, isotonicity, stability and the like. In this specification, the administration method includes oral administration, parenteral administration (for example, intravenous administration, intramuscular administration, subcutaneous administration, intradermal administration, mucosal administration, intrarectal administration, intravaginal administration, local administration to the affected area, Skin administration, etc.). Formulations for such administration can be provided in any dosage form. Examples of such a pharmaceutical form include a liquid, an injection, and a sustained release agent.

  The amount of the composition of the present invention can be easily determined by those skilled in the art in consideration of the purpose of use, the target disease or condition (type, severity, etc.), the age, weight, sex, medical history, etc. of the subject. it can. The frequency with which the treatment method of the present invention is applied to the subject also takes into account the purpose of use, the target disease or condition (type, severity, etc.), the patient's age, weight, sex, medical history, and treatment course. Can be easily determined by those skilled in the art. Examples of the frequency include administration every day to once every several months (for example, once a week to once a month). It is preferable to administer once a week to once a month while observing the course.

  As used herein, an agriculturally or pharmaceutically “acceptable carrier” refers to a substance that is used when producing foods, pharmaceuticals, or veterinary drugs and that does not adversely affect active ingredients. Such pharmaceutically acceptable carriers include, for example, antioxidants, preservatives, colorants, flavors, and diluents, emulsifiers, suspending agents, solvents, fillers, bulking agents, buffering agents, delivery agents. Examples include, but are not limited to, vehicles, diluents, excipients and / or agricultural or pharmaceutical adjuvants.

  When the present invention is used in other applications such as foods and agricultural chemicals, foods and agricultural chemicals can be prepared while complying with regulations stipulated by the authorities.

  Acceptable carriers include any material known in the art. Pharmaceutically acceptable carriers that can be used in the present invention include antioxidants, preservatives, colorants, flavors, and diluents, emulsifiers, suspending agents, solvents, fillers, bulking agents, buffering agents, Delivery vehicles, diluents, excipients and / or pharmaceutical adjuvants include but are not limited to them. Typically, the compositions of the invention are administered in the form of a composition comprising a support and a peptide or variant thereof together with one or more physiologically acceptable carriers, excipients or diluents. .

  Acceptable carriers, excipients or stabilizers used herein are non-toxic to the recipient and are preferably inert at the dosages and concentrations used, and lactose Sucrose esters and starches, phosphates, citrates, or other organic acids; antioxidants (eg, ascorbic acid); low molecular weight polypeptides; proteins (eg, serum albumin, gelatin or immunoglobulin); hydrophilic Functional polymers (eg, polyvinylpyrrolidone); amino acids (eg, glycine, glutamine, asparagine, arginine or lysine); monosaccharides, disaccharides and other carbohydrates (including glucose, mannose, or dextrin); chelating agents (eg, EDTA) Sugar alcohols (eg mannitol Or sorbitol); salt-forming counterions (eg, sodium); and / or non-ionic surfactants (eg, Tween, pluronic or polyethylene glycol (PEG)), but are not limited thereto. .

  Excipients used herein include, but are not limited to, lactose, sucrose esters and starch.

  The dried potato composition of the present invention contains dried plant components other than the dried potato. This plant component is pearl barley (Yokuinin), Hub tea (Keiko), turmeric, brown rice, barley, kelp, wolfberry, wolfberry leaves, oyster leaves, tea leaves, ginkgo leaves, mandarin peel, tochu, shiitake, It is at least one selected from the group consisting of Ganoderma, Agaricus (Princess Matsutake) and Maitake. These serve mainly to improve the taste when drinking the extract from the composition of the present invention. Furthermore, it mix | blends in order to ingest together the active ingredient of these plant components. These plant components may be in a dry state that does not cause mold or decay when left at room temperature. The moisture content is usually 2% to 15%, preferably 4% to 12%, most preferably about 7%. These plant components are available as cultivated products or commercial products, and are roasted and dried as necessary. Materials with a low moisture content (for example, commercially available pearl barley, hub tea, brown rice, barley, wolfberry) do not need to be dried. Also in this drying, the conditions used for the drying process of the above-mentioned Baotoku can be preferably employed. The plant component is cut into an appropriate size as necessary. Drying can take place before and after this cutting. Materials of relatively small size such as pearl barley, hub tea, brown rice, barley, wolfberry can be used as is without cutting. As the tea leaves, commercially available green tea, oolong tea and the like can be used. The plant components can be included in the composition alone or in combination. Combinations of plant components include pearl barley, hub tea, and turmeric; barley, tea leaves, wolfberry leaves, and ginkgo leaves; shiitake mushrooms, reishi, agaricus, and maitake; The dried plant component is contained in an amount of 200 parts by weight or less, preferably 1 to 100 parts by weight, and more preferably 2 to 100 parts by weight, with respect to 100 parts by weight of the dried dried beetle. For example, when using a mixture of pearl barley, hub tea, and turmeric as plant components, 10 to 50 parts by weight of pearl barley, 10 to 50 parts by weight of hub tea, and 1 to 10 parts of turmeric with respect to 100 parts by weight of dried dried corn. Part by weight is appropriate. A particularly preferred combination of dried plant component products is pearl barley, hub tea, and turmeric.

  In general, the above-mentioned dried beetle and dried plant component are packaged in a bag from which their contents can be extracted so that they can be handled easily. Such a bag is a permeable bag such as a mesh material made of paper, synthetic resin, natural fiber, or a filter material. A paper-made or resin-made mesh material bag used for decocting a traditional Chinese medicine or a paper bag used for a tea bag can be suitably used. An extract is obtained by extracting the composition of the present invention with normal hot water for 5 to 20 minutes. By providing this for beverages, corn and other plant components are ingested and their medicinal effects can be expected. In extraction and drinking, the composition of the present invention is usually used so that dried dried citrus is 3 to 10 g per day. When a sachet and other plant components are fragmented and a paper bag made of a filter material for a tea bag is filled with a single dose, the advantage is that extraction is simple and extraction time is short.

  When a plant component is used, the unique fresh odor and bitterness of the spinach extract obtained from the composition of the present invention is eliminated, and drinking is easy. It can be expected that various medicinal properties possessed by Baotoku can be obtained by drinking the extract obtained from such Baitoku composition.

  The balm composition of the present invention can usually be individually packaged in an aluminum pack or the like for the purpose of improving its storage stability. For example, after filling the above extractable bag with the boiled hoe composition, it is individually packaged in an aluminum pack. If necessary, an oxygen absorbent, a desiccant, or the like can be enclosed for the purpose of preventing oxidation or preventing moisture absorption.

  Instructions are attached to the individual packages as necessary.

  In the present specification, the “instruction” describes the method of using the present invention or the method of ingesting and the like, and describes the ingesting person such as a doctor or a subject. The instructions can be attached to indicate how to use the food, medicine, etc. provided as a kit (eg, individual package, etc.). This instruction describes a word for instructing a procedure for administering the food or medicine of the present invention. This instruction is prepared in accordance with the format prescribed by the national supervisory authority (for example, the Ministry of Health, Labor and Welfare or the Ministry of Agriculture, Forestry and Fisheries in the case of Japan, the Food and Drug Administration (FDA) in the United States, etc. in the United States). It is clearly stated that it has been approved by the supervisory authority. The instruction sheet is a so-called package insert, and is usually provided in a paper medium, but is not limited thereto. For example, an electronic medium (for example, a home page provided on the Internet (web) Site), e-mail, SMS, PDF document, etc.).

  The effect of the composition of the present invention is exerted even when ingested before drinking, during drinking, or after drinking. Preferably, it may be advantageous to take the medicine immediately before drinking (for example, 1 hour to 1 minute before).

  In the present specification, “drunkenness” refers to suppressing, reducing or reducing the action of ethanol (alcohol). The effect of sickness can be determined by measuring alcohol in the breath. Since the amount of breath alcohol correlates with the blood alcohol concentration, the effect of drunkness can also be measured by measuring blood alcohol. Alternatively, the effect of drunkness can be measured by using the presence or absence of an intaker's headache, nausea, discomfort and the like.

The effects of blood alcohol concentration and severity are as follows.

  Similarly, the alcohol concentration in the breath is explained as follows. The relationship between the breath alcohol concentration and the blood alcohol concentration is 1: 2000. In other words, “alcoholic driving” is determined to have an expired alcohol concentration of 0.15 mg / l or higher or a blood alcohol concentration of 0.3 mg / ml. In the Road Traffic Law Enforcement Ordinance (October 11, 1955), the (degree of alcohol), Article 44-3, Article 109, Paragraph 1, Item 7-2 of the Act The degree of alcohol held in the body as stipulated by the government ordinance is 0.3 milligrams per milliliter of blood or 0.15 milligrams per liter of breath. The effect of alcohol on driving the car ・ No drinking (alcohol concentration in breath is 0.00 mg / 1) ・ Low concentration (about 0.12 mg / 1) ・ Medium concentration (about 0.20 mg / 1) ・ High There are four levels of concentration (about 0.25mg / 1), and when you look at "Slightly simple response time" and "Slightly complex response time", you can see the effects of drinking on each. However, the influence of drinking is seen in a somewhat complicated judgment. It is clear that people who are strong in liquor, like those who are weak in liquor, have a slower reaction time as the alcohol concentration is higher (Science Police Research Institute, Traffic Safety Laboratory: "Survey study on effects on alcohol"; Effects of alcohol on driving (http://www.keishicho.metro.tokyo.jp/kotu/insyu/insyu1.htm).

  In this specification, the effect of drunkenness is that the concentration of alcohol in the breath is usually 0.35 ppm or less, typically 0.30 ppm or less, preferably 0.25 ppm or less, more preferably 0.20 ppm or less. More preferably, it is 0.15 ppm or less, still more preferably 0.10 ppm or less, still more preferably 0.05 ppm or less, and most preferably lower than the detection limit (substantially 0.00 ppm). The breath alcohol can be measured by any method known in the art, and a commercially available device (for example, a sociak sold from a central automobile) can also be used.

  As used herein, “the action of alcohol (ethanol)” includes any action that alcohol (ethanol) causes on the body. Such actions can include, but are not limited to, headache, nausea, discomfort, malaise, wandering, palpitation, and hyperventilation. As a result of the action of alcohol, for example, hangover or hangover occurs.

  References such as scientific literature, patents and patent applications cited herein are hereby incorporated by reference in their entirety to the same extent as if each was specifically described.

  As mentioned above, although this invention has been illustrated using preferable embodiment of this invention, this invention should not be limited and limited to this embodiment. It is understood that the scope of the present invention should be construed only by the claims. It is understood that those skilled in the art can implement an equivalent range based on the description of the present invention and the common general technical knowledge from the description of specific preferred embodiments of the present invention. Patents, patent applications, and documents cited herein should be incorporated by reference in their entirety, as if the contents themselves were specifically described herein. Understood.

  Hereinafter, although an example explains the composition of the present invention in detail, the present invention is not limited to this. The foods and chemicals used in the following are commercially available from the well-known raw material supply companies in the food industry, which are listed in, for example, the Health Distribution Newspaper (published by New Magazine), unless otherwise specified. I used something.

(Example 1: Raw eating effect of Baotoku)
Raw boiled corn (water content 88%) cultivated by the bottle cultivation method was used as it was. In this example, a conserved strain of IMB Co., Ltd. (Hericium erinaceum IMB-H1 was used as the rotifer, but it is understood that other strains can also be used.・ Other typical strains available from MB Co., Ltd. are commercially available from Kinox Co., Ltd. and Shinkoen Co., Ltd. It is understood that cypress is native all over the world, and that it is possible to use such cultivated stuff, which is also called lion head in Europe. It is.

  Fresh boiled cucumbers were fed 14 g (about 1.7 g as an anhydride) to a subject (5 adult men) or 28 g (about 3.4 g as an anhydrate) to a subject (5 adult men), and after 10 minutes beer ( (Alcohol content 5%) 500 ml was ingested. As a control, an experiment was also conducted in which the subject was not fed potato but was fed 1.8 g potato starch and drinking a colleague's beer.

  The effect of drunkness was determined by measuring the alcohol concentration in exhaled breath. The alcohol concentration in exhaled breath was measured using an alcohol detector (Sociac, Chuo Motor Co., Ltd., measurement range 0.00-1.00 ppm).

  The control group and the test group used the same test subject, and the test itself was performed at least 1 week apart.

  The test will have a placebo effect with the appearance and weight (300 mg) in a similar product form so that the test evaluator and the subject will be concealed and the subject will not know what they are drinking. The test was performed so that there was no.

  The results are shown in Table 1 below for the results of no eating and in Table 2 for 28 g raw food.

As shown in the table, it has been clarified that intake of fresh boiled cucumber prior to drinking reduces the alcohol concentration in the breath.

  Experiments were conducted using a rice germ ferment extract powder, which has been known to have a drunk effect, as a control. Instead of the fresh fresh cucumber, 1.8 g of 5 subjects were given rice germ fermented extract powder (available from Toyoen Enzyme, etc.), and 10 minutes later, 500 ml of beer similar to the above was ingested. The results are shown in Table 3.

As described above, it was revealed that fresh boiled cucumber has the same drunkness effect as the rice germ fermented extract powder. The fermented rice germ extract powder is one of the components that are considered to have the highest drunkness effect at present, so that the high effect of Baotoku can be understood. Conventionally, there is no known effect of preventing or reducing side effects caused by drinking when fed with chanterelles, and the present invention has found an unexpected effect.

(Example 2: Effect of dried spinach)
In place of the fresh fresh hoe, the effect of the dried hoe was confirmed in this example. Raw boiled cucumbers cultivated by the bottle cultivation method were cut into (for example, 1.5 cm × 1.5 cm × 0.5 cm), and these were arranged in a cello so as to be easily dried. Next, this was put into a drier and air-dried at about 26 to 30 ° C. for about 12 to 36 hours (cold air drying method). The moisture content of the obtained dried dried hoe was about 8% by weight. If the moisture is about 6 to 15%, it can be preferably used in this embodiment. Next, this dried dried beetle was finely pulverized and used for testing in a powder state.

  The results are shown in Table 5 below for Table 4 and 3.6 g for Table 1.8.

As shown in the table, it was clarified that the intake of dried sardine before drinking reduced the alcohol concentration in the breath more than fresh sardine (same dry weight). Therefore, it became clear that the effect of drunkness increases unexpectedly by drying Baotoku. In addition, when dried, it was also shown to exhibit a higher drunk effect than rice germ extract, which has been said to show the best effect.

  Bacon is rich in dietary fiber (37.0 g per 100 g of dry matter) and has a unique odor, and when ingested in large quantities at once, the gastrointestinal sensation is often uncomfortable. Therefore, when it dries, an effect rises more than a water | moisture content reduction has shown that dried dwarf is more preferable as a drunking agent.

  In order to further confirm whether the amount of the effect of drunkness does not cause discomfort in the gastrointestinal tract, 6 subjects (3 adult boys a, b, c and 3 adult girls) d, e, f) 6 mg (1.8 g) to 30 (9.0 g) at a time, 300 mg of grains were drunk at a time, and then the presence or absence of stomach discomfort, loose stool or constipation was investigated. . Drinking was 20 minutes after lunch and each test was conducted at least 5 days apart.

As shown in the table, it has been found that the number of subjects who feel discomfort increases as the intake of dried dried citrus increases, and intestinal abnormalities such as stool softening or constipation are also found. However, it has been revealed that there are almost no side effects on the gastrointestinal tract at intakes such as 1.8 g and 3.6 g, which have a drunkenness effect. Since this product is considered to be often consumed as a food rather than as a pharmaceutical product, it is considered that it is excellent in taking feeling.

(Example 3: Effect of the extract)
One sachet of baked pea composition obtained in Example 2 was decocted with 1 liter of hot water for about 15 minutes to obtain an extract.
Separately from this, 10 g of dried dried potato was filled in a bag in the same manner as in Example 1, and an extract was obtained in the same manner. These extract liquids (decoction liquids) were brought to 10 ° C., 30 ° C., or 70 ° C. and were drunk 10 minutes before drinking, and the effects of drunkness were confirmed by 10 subjects. The results are shown in the following table (male: A to E, female: F to J).

  In addition, the drinking dose of the extracted extract was 200 ml in all samples, and the temperature was 30 ° C. The effect of drunkness was confirmed by 10 subjects. The results are shown in the following table.

In this way, it is confirmed that even the extract of Baotoku has an intoxicating effect. The effect seems to be comparable to dry balm.

(Example 4: Effect of mixing with other components)
Next, in addition to the dried spinach, other drunk ingredients were tested for the effect of drunkness. As other ingredients, autumn turmeric powder, fermented rice germ extract powder, yogurt powder, oyster extract powder, zinc yeast (containing 10% zinc), vitamin C, citric acid and the like were tested. These materials include: Autumn Turmeric End: Nagayodo Head Office Osaka “Turmeric”; Rice Germ Ferment Extract End Powder: Toyo Fermentation Tokyo “GMT-ALC”; Yogurt Powder: Morinaga Milk Industry Tokyo Yogurt Powder “ YP-A ”; Oyster Extract Powder: Bizen Kasei Co., Ltd. Okayama“ Oyster Extract Powder ”; Zinc Yeast: Manufacture Kelatron Corporation USA, Tokyo Kenko Tsusho Co., Ltd.“ Beer Yeast Dry Powder (Containing 10% Zinc) ”; Vitamin C: BASF Takeda Vitamin Co., Ltd. Tokyo “Vitamin C”; Citric acid: Fuso Chemical Industry Co., Ltd. Osaka “Citric acid”, etc. The blending ratio is as follows.

Table 8 includes all of the above components, only rice fermented fermented extract powder, and, as a control, excluding boiled rice and rice germ fermented extract powder, excluding rice germ fermented extract powder, The blending ratio of the product excluding is shown. As the excipient, for example, sucrose, potato starch or the like was used. As a placebo control, those using potato starch instead of these ingredients were used.

  The results are shown in the following table.

From these results, it is clear that the combination of balm potato alone and the fermented rice germ extract powder promotes a decrease in the alcohol concentration in the breath and promotes alcohol degradation rather than the balm potato alone or the fermented rice germ extract powder alone. became. Although the rice germ fermented extract and Baotou have side effects that cause diarrhea, the side effects are expected to be reduced. The effect of drunkness was further enhanced by adding autumn turmeric, yogurt powder, oyster extract powder, zinc yeast, vitamin C, and citric acid, respectively.

(Example 5: Experience after drinking)
In order to confirm the body sensation after ingesting and drinking alcohol, five test subjects (F, G, H, I, and J) were allowed to drink each test product prepared in Examples 2 to 4, and 10 minutes. Later, 3 drinks of sake (alcohol content of about 16%, 540 ml) were taken over about 30 minutes, and the physical condition (presence of headache and nausea) 3 hours after the start of drinking was investigated.

  Furthermore, after a period of one week, the same test was started again, and the physical condition (awakening, headache and nausea) 10 hours after the start of drinking was investigated. The results are shown in the following table. The evaluation was expressed as an absolute evaluation in five stages. [1 = bad, 2 = somewhat bad, 3 normal, 4 = somewhat good, 5 = good].

As a result, it became clear that Baotoku generally exerts drunkness effects without hangover effects such as poor awakening, headache, and nausea without causing changes in physical condition. It has been found that the effect is more preferable when all the components are combined, but it is understood that the effect is sufficient even with Baotoku alone.

(Example 6: Effect after drinking)
Next, it is demonstrated that Baotoku has an intoxicating effect even when taken after drinking.

  The formulation described in Example 5 was ingested 10 minutes after 5 subjects ingested 500 ml of beer (5% alcohol). Other experimental conditions were performed as described in Example 1. The results are shown in the following table.

As described above, it has been clarified that the drunkness effect of Baotoku is exerted in the same manner even when ingested before drinking or during or after drinking.

(Example 7: Comparison with a commercial product)
Next, it was compared with the commercially available super sickness α (Wellness Hit Research Division, Kobe Internet Sales Co., Ltd.) and Anom (Unix Internet Sales Co., Ltd.).

  A control experiment was conducted between the formulation described in Example 5 and the commercial product. The experiment was performed as described in Example 1 except that the ingestion was the subject of each test. The results are shown in the following table.

The composition of the super sickness α and the refreshing anome are as follows.
<Product name> Anom: calcined calcium, seasoning (inorganic salt), flavor, sweetener (acesulfame K). Calcinated calcium = baked shells, eggshells and fish bones. Becomes calcium oxide and calcium carbonate. By containing moisture, it becomes calcium hydroxide. Acesulfame K = compositional formula C ₄ H ₄ KNO ₄ S, molecular weight 201.24, 200 times sweeter than sugar.
Super sickness α: Ingredients: Autumn turmeric, ginseng, plum, lemon, oysters, yucca, mushrooms, soybeans, vitamin C.

(Example 8: Effect of composition when odor is extinguished)
Next, the effect of drunkness when other ingredients such as pearl barley, hub tea, and turmeric were added to the spinach to deodorize them was verified. The prescription conformed to JP-A-11-075793. Specifically, it is as follows.

  Raw balm cultivated by the bottle cultivation method was chopped into 1.5 cm × 1.5 cm × 0.5 cm, and these were arranged in a cello. Next, this was put into a drier and air-dried at 25 ° C. to 30 ° C. for about 12 hours. The water content of the dried dried potato was about 10% by weight. Next, 10 g of this dried dried potato, 2.0 g of pearl barley, 3.0 g of hub tea, and 0.4 g of turmeric were filled into a bag made of a paper filter material of 12 cm × 15.5 cm.

  One wrapping of the thus-packaged confectionery composition thus obtained was decocted with 1 liter of hot water for about 15 minutes to obtain an extract. Separately from this, 10 g of dried dried potato was filled in a bag in the same manner as in Example 1, and an extract was obtained in the same manner using this bag. These extraction liquids (decoction liquid) were set to 10 ° C., 30 ° C., or 70 ° C., and an experiment as in Example 1 was performed by five subjects. The results are shown in the following table (male: A, B, C, female: F, G).

  In addition, the drinking dose of the extracted extract was 200 ml in all samples, and the temperature was 30 ° C.

* Beverage composition for beverages (Japanese Patent Laid-Open No. 11-075793, Japanese Patent No. 3527625)
The composition containing the licorice prepared by this formulation contains other plant components other than the corn, and the odor and bitterness derived from the corn rot disappears from relatively low to high temperatures, and the umami is easily added. In addition to being able to be drunk, it became clear that the effect of drunkness was also retained.

(Example 9: Presence or absence of side effects of repeated use)
Even when the formulations shown in Examples 2 and 5 were drunk daily and continued for 1 month, it was verified whether or not there were no side effects. Specifically, the composition was instructed to be taken twice a day for 2 days. After one month, when the effect was inquired, the following answer was obtained (with duplicate answers).

* Change in body weight: It was examined whether there was a change within ± 2% after the end of the test relative to the body weight (kg) at the start of the test.

  Table 20-1. Is a group with drinking (5 men, 5 women), Table 20-2. Is a group without drinking (5 men and 5 women). The numbers show how many times the symptoms were felt during a month (30 days). Table 20-1. There was a report that they felt <discomfort>, but the degree was very light.

  In this way, it became clear that the effects of drunkness continued and had little effect on health.

  As mentioned above, although this invention has been illustrated using preferable embodiment of this invention, it is understood that the scope of this invention should be construed only by the claims. Patents, patent applications, and documents cited herein should be incorporated by reference in their entirety, as if the contents themselves were specifically described herein. Understood.

  The present invention is useful in pharmaceuticals, the food industry, services that provide alcohol, and the like.

FIG. 1 shows the correlation between the alcohol concentration in exhaled breath and the reaction time. The y axis shows the reaction time (seconds), and the horizontal axis shows the level of alcohol concentration in the breath. It is statistically significant (F (3,117) = 10.02, p <0.01) at the 1% level. The reaction time is the time from when the stimulus is presented on the screen until the driver releases the accelerator. People who are weak and strong in alcohol are the result of self-assessment.

Claims (33)

A composition for preventing or treating an action caused by drinking, comprising a component derived from Baotou (Yamabushitake). The composition of claim 1, wherein the component comprises fresh balm, dried balm or balm extract. The composition according to claim 1, wherein the component comprises an extract of citrus. The composition of claim 1, wherein the component comprises an alcohol or water extract. The composition of claim 1, wherein the component comprises dried citrus. The composition according to claim 5, wherein the dried spinach is prepared by a cold air drying method. The composition of claim 5, wherein the dried spinach is dried to less than about 10% moisture. The composition according to claim 5, wherein the dried spinach is dried at 26 ° C. to 30 ° C. for 12 to 48 hours. The composition according to claim 1, wherein the dried spinach is contained in an amount of 100 mg or more. The composition according to claim 1, wherein 1.8 g or more of the dried spinach is contained. The composition according to claim 1, wherein 5.4 g or less of the dried spinach is contained. The composition according to claim 1, wherein 1.8 to 5.4 g of the dried spinach is included. The composition according to claim 1, wherein 1.8 to 3.6 g of the dried spinach is included. Furthermore, the composition of Claim 1 containing an embryo fermentation extract. 15. The composition of claim 14, wherein the horseshoe pod is a dried sorghum and is mixed with the embryo fermented extract in a ratio of 10: 1 to 1:10. 15. The composition according to claim 14, wherein the corn is a dried potato and mixed with the fermented ferment extract in a ratio of 2: 1 to 1: 2. The composition according to claim 1, further comprising a component selected from the group consisting of fermented rice germ extract powder, autumn turmeric powder, yogurt powder, oyster extract powder, zinc yeast, vitamin C and citric acid. The composition according to claim 1, further comprising all further components selected from the group consisting of fermented rice germ extract powder, autumn turmeric powder, yogurt powder, oyster extract powder, zinc yeast, vitamin C and citric acid. The composition of claim 1 further comprising an excipient. 20. A composition according to claim 19, wherein the excipient is selected from the group consisting of lactose, sucrose esters and starch. The following composition:
Per 6 capsules (1800mg) powdered beetle (Yamabushitake) powder 100-1000mg 5.6-55.6%
Autumn turmeric powder 100-1000mg 5.6-55.6%
Rice germ ferment extract powder 200-500mg 11.1-27.8%
Yogurt powder 100-500mg 5.6-27.8%
Oyster extract powder 100-500mg 5.6-27.8%
Zinc yeast (containing 10% zinc) 50-300mg 2.8-16.7%
Vitamin C 20-100mg 1.1-5.6%
Citric acid 50-500mg 2.8-27.8%
Add a proper amount of excipients, etc. to a total of 1800 mg,
The composition according to claim 1, comprising the active ingredient in a composition ratio. The composition of claim 1 further comprising a pharmaceutically acceptable carrier. The composition according to claim 1, which is provided as a food. The composition according to claim 1, which is taken before, during or after drinking. The composition according to claim 1, which is taken before drinking. The composition according to claim 1, further comprising a dried plant component other than hoeweed. 27. The composition of claim 26, wherein the dried plant component comprises pearl barley, hub tea, and turmeric. A method for preventing or treating the effects of drinking,
A) A step of allowing a subject to ingest a component derived from Baotou before drinking, during drinking or after drinking,
Including the method. 29. The method of claim 28, wherein the ingestion is performed prior to drinking. A method for producing a composition for preventing or treating the effects of drinking, comprising:
A) a step of providing a peanut; and B) a step of mixing the component derived from the peanut with other necessary components to form a composition. 32. The method of claim 30, further comprising the step of drying the licorice. The method according to claim 31, wherein the drying is performed by a cold air drying method. Use of Baotou for producing a composition for preventing or treating the effects of drinking.