TW200908992A - Anti-fatigue agent - Google Patents

Abstract

Disclosed is an anti-fatigue agent, an endurance-promoting agent, a nutritive or tonic agent, or a muscle-building agent which comprises a plant Dioscorea esculenta or a processed product of the plant as an active ingredient. Also disclosed is a food, feed or medicine comprising the agent. Further disclosed is a method for producing the food, feed or medicine.

Description

200908992 IX. Description of the Invention: [Technical Field of the Invention] The present invention relates to an anti-fatigue agent, an endurance enhancer, a nourishing tonic or a muscle enhancer which can be used in the medical or health food field. [Prior Art] In recent years, with the improvement of people's health aspirations and the development of sports science, the industry is developing foods with endurance enhancement, fatigue recovery or prevention, strong growth or muscle enhancement. Such foods can enhance the physical or mental endurance necessary for normal social life, or promote the recovery and prevention of fatigue. Therefore, not only athletes expect it to improve their athletic ability, but consumers also expect to develop such food. . In particular, in developed countries, physical fatigue or mental fatigue and overwork caused by stress or disorder of life have become a problem, so people are expected to develop anti-fatigue effects, endurance enhancement, nourishment or muscle strengthening. The food or medical material that acts. For example, it is disclosed in the patent document , that there is an anti-fatigue agent containing coenzyme Q10 and lipoic acid; and, in the patent Ut 2, a force enhancer and an anti-fatigue agent containing a golden lotus are disclosed. There are many types of yam, and mainly cultivated in Japan, such as big potato, wild yam, home mountain - scorpion, thorn potato, etc., and used for eating. The yam is cultivated in the south of Kyushu and is said to be originated in Thailand and Vietnam. [Patent Document 1] Japanese Patent Laid-Open Publication No. Hei. No. 20064 3773 No. [Patent Document 2] Japanese Patent Laid-Open Publication No. Hei No. Hei 2 No. 5-2〇〇39〇 [Summary of the Invention] [Problems to be Solved by the Invention] 130108.doc 200908992 The object of the present invention is to provide an anti-fatigue agent, an endurance enhancer, a nourishing strongener or a muscle enhancer which can be used in the medical or health food field, a food, a feed or a medicine containing the preparation, and a source which can be used as such a preparation An extract from food and a method of producing the extract. [Technical means for solving the problem] The first invention of the present invention relates to an anti-fatigue agent, a force-enhancing agent, a nourishing strongener or a muscle-enhancing agent which contains a mashed potato or a processed material derived from thorny yam as an active ingredient. The first of the invention! In the invention, as the treatment derived from the yam, the dried powder, water, ethanol, aqueous ethanol, acetone extract, and components obtained from the extracts can be exemplified. The second invention of the present invention relates to a food containing the anti-fatigue agent, the endurance enhancer, the nourishing strongener or the muscle enhancer of the first invention of the present invention, or a third invention of the present invention, relating to the third invention containing the present invention. Anti-fatigue agent, endurance enhancer, barely anal fistula caught by the secret% _

Step. In the fourth invention of the present invention, as the aqueous ethanol, 1 to 85% (v/v) of aqueous ethanol can be exemplified. The fifth invention of the present invention relates to an extract obtained by the present invention. The method of the fourth aspect of the invention is the food or feed containing the invention. The extract of the fifth invention of the present invention relates to a medicine containing the extract of the fifth invention of the present invention I30108.doc 200908992. From the fatigue of the steps of the treatment of the Lai's treatment = pre-::::: method, nourish the strong method, or - reluctantly:::: or: from the treatment of the deletion of the treatment The preparation of π months, the food or feed of the second invention of the present invention, or the medicine of the third invention of the present invention.

Further, as the m-like sample of the present invention, a treatment for fatigue recovery or prevention, a method for enhancing endurance, a method for nourishing or strengthening, or a method for strengthening muscles may be provided. The above-mentioned anti-fatigue agent, endurance enhancer, nourishing strongener or muscle reinforcing agent, the food of the present invention, or the medicine of the present invention can be used as the mashed potato or the mashed potato pretreated product. Further, as another aspect of the present invention, anti-fatigue is provided! The use of thorny yam or the treatment of squid and yam from the manufacture of financial enhancers, nourishing agents or muscle enhancers. Further, according to the present invention, it is possible to provide the use of the mashed potato or the stalk-derived mashed potato in the manufacture of foods for fatigue resistance, endurance enhancement, nourishment or muscle enhancement. Further, according to the present invention, it is possible to provide a mashed potato or a treatment derived from thorny yam in the manufacture of medicine for anti-fatigue, endurance enhancement, nourishment, or muscle enhancement. Further, as another aspect of the present invention, there can be provided a method for producing a food containing thorny potato or a treatment derived from thorny yam, which comprises: the label can be used for fatigue recovery or prevention, endurance enhancement, nourishment or The step of muscle enhancement. 130108.doc 200908992 Further, as another aspect of the present invention, a food or feed for anti-fatigue, financial enhancement, nourishment or muscle enhancement can be provided, which is characterized in that it contains thorns (four) or is derived from the treatment of yam. Things. As the food or food, for example, food or feed indicating that it can be used for fatigue recovery or prevention, endurance enhancement, nourishment or muscle enhancement can be exemplified. [Effects of the Invention] The product can provide a treatment containing thorny yam or yam yam, "Λ, / + , labor endurance enhancer, nourishing strongener, enhancer' food, feed or containing the preparation Medicinal, and: used as a preparation for the preparation of the extract from the thorn collar and the method of the extract. The anti-fatigue (four), endurance increase _, nourishing strongener or muscle increase agent can not only improve the athlete's ability, but also be used as a food or medicine material with fatigue recovery or prevention in social life. [Embodiment] It is said that the thorn collar used in the present invention (scientific name: Di_ea ^ called, which is also known as sweet potato, is mainly cultivated in the south of Kyushu. The use of any part is not limited) For example, a rhizome, a root, a stem, a leaf, or a rhizome thereof can be used. It is particularly preferable to use the treatment of the hedgehog from the present invention, and for example, if it is a raw material of the yam, , 疋, 限定, for example, can be exemplified, dry powder, :::, no special, juice, crush, chemical treatment, stroke, pulverized dry powder, ground material or extraction In the invention, as the drying # 源自 蓣 & amp amp amp amp 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。. The pulverization of the present invention is sometimes referred to as the pulverized material of the present invention, and the method of pulverizing the yam of the yam is the method of smashing the yam, and the pulverizer is exemplified by a pulverizer for appropriate far infrared ray treatment. , then use the .# method. In addition, the powdery material obtained from the pulverized material of the town is obtained. After the lyophilization, the pulverization is carried out. In the present invention, as a ground material, 〇* is usually pulverized and pulverized into pieces of various automatic grinding (4) to prepare a ground material. The dish will be ground in the application specification, and the material obtained by the method of extracting the extracting solvent from the extracting material to the raw material plant will be extracted. The well-known method of smashing the ancients...the method of stroke is carried out as follows. For example, the raw materials may be pulverized or shredded, and the agent may be used in batch or continuous manner as the extract is obtained. The extraction solvent to be used is particularly limited, and examples thereof include alcohols such as water, 醢田& w 〇 私 、, 甲, isopropyl alcohol, and the like, and a class of methyl acetate and methyl ethyl acetate. A hydrophilic or lipophilic solvent such as ethyl acetate 'chloroform, etc., may be used alone or in accordance with the requirements, or an appropriate mixture may be used. As an example of using the mixed solution as an extraction solvent, there is no particular limitation. For example, various aqueous solutions can be used, for example, 10 to 100% (v/v), preferably 2 to 9 % (v/v), more preferably 40 to 80% (Wv) can be used. An aqueous solution. The present invention is particularly useful as an extraction solvent, water, and B. Alcohol, aqueous ethanol or acetone; as aqueous ethanol, it is preferred to use 1 to 85% (v/v) of aqueous ethanol. The amount of extraction solution I30108.doc 200908992 can be appropriately determined, usually relative to the raw material plant. The weight of the raw material plant (for example, when the raw plant is a raw plant) is preferably 0.01 to 40 times, more preferably 丨 4 to 4 times. The extraction temperature is also It may be appropriately determined according to the purpose. When extracting with water, it is usually preferably 4 to 13 Torr, more preferably *1 〇 to 1 &£> c. Further, when the solvent contains ethanol, it is safe. In view of the above, it is preferably 4 to 6 (the range of rc. The extraction time can also be considered in consideration of the extraction efficiency, and it is usually preferably in the range of several seconds to several days, more preferably in the range of 5 minutes to 24 hours. The method of setting the raw material, the extraction solvent, and the extraction temperature. For example, the extraction operation may be carried out while stirring, or after standing, 'χ, or may be extracted several times as needed. By the above operation, the present invention can be obtained. The extract used in the invention. The extract can be carried out as needed Excipients that have been subjected to anti-fatigue, endurance-enhancing, nourishing or muscle-enhancing effects by appropriate treatments such as sputum, centrifugation, concentration, ultrafiltration, and molecular therapies, and may also contain two kinds of extracts. The extract obtained from the raw material plant by the different extraction methods is used as the extract of the present invention, and the method for producing the aqueous ethanol extract is exemplified. The root of the stalk is used as a raw material, and the dried stem and the cut are used. = a sheet-like dried product or a dry powder, which is impregnated, for example, in a dry t-weight, preferably in an amount of 2 to 4 times, more preferably 5 to 2 inches, more preferably The aqueous ethanol is extracted by using hydrazine (v/v), preferably *5~8〇% (ν/ν), more preferably 1〇~75%b~) Ethanol. The extraction conditions are as follows: the extraction temperature is 4 to 13 (rc, preferably 4 110 C, more preferably 4 to 1 〇〇〇 c, more preferably 4; extraction 13 〇 l 〇 8, d〇c 200908992 5 minutes to 48 hours, preferably 30 minutes to % hours is 24 hours; the extraction operation is carried out after standing, stirring or shaking: the obtained extract is separated by filtration or centrifugation. The extract can be used as the aqueous ethanol extract of the present invention. The aqueous ethanol extract of the present invention and the dry powder phase of the yam yam show a higher anti-fatigue effect, endurance enhancement effect, and Muscle, strong action. Nourish and strengthen the 'components obtained by separating the present invention by a well-known method, or by repeating several separation operations' are also included in The extract of the present invention can be used as the above-mentioned method: extraction, fractionation, column chromatography, thin layer chromatography, etc. Here, the above extraction solvent can be suitably used at the time of extraction. 'The juice extracted from the yam, which is used in the present invention, The method for producing the juice is not particularly limited as long as it is a well-known vegetable juice extraction method, and for example, a spiral type, a 齿轮 gear type, a cutting type, etc. can be used. The machine or the juicer is used to smash the juice. In addition, it can be (4) fine or ground as a pre-treatment, and then the above-mentioned juicer or cloth can be squeezed to obtain the juice. The so-called mash is to press the raw material plant. The shredder is usually larger than the pulverized material, and can be produced, for example, by using a house shredder. The chemical treatment product is not particularly limited, and the raw material plant is subjected to acid treatment. The alkali treatment, the oxidation treatment, the reduction treatment, and the like are obtained, for example, by immersing the raw material plant in a cockroach acid or an organic hydrazine such as a y*, a salt, a sputum, a nitric acid, a citric acid, or an acetic acid.戎 乂 乂 无机 虱虱 虱虱 、 、 、 、 、 、 、 130 130 130 130 130 130 130 130 130 130 130 130 130 130 130 130 130 130 130 130 130 130 130 130 130 130 130 130 130 130 130 130 130 130 130 130 130 130 130 130 130 All substances. # Μ ^ ^ ^ Treatments, such as typhus _, fiber (four), wood poly gfe - ^ „ / temple powder enzyme, mannan ^ *, Shuang Li 'in the use of microorganisms as an enzyme source of enzyme reactants (for example, 酦 ', , , -^ . /± m) For example, the above-mentioned enzyme can be applied to the plant body in the appropriate buffer solution, which is treated by the above-mentioned fermentation treatment. All the substances. In the specification of the present application, the anti-fatigue agent, the agent, and the muscle reinforcing agent can be used as a stalking force: 曰 from the box to nourish and strengthen as an active ingredient, and these can be used alone = the treatment of yam yam = 纟In the invention, the shape of the preparation is not particularly limited, and may be any of a powder shape, a solid shape, and a liquid shape. Further, the above-mentioned treated material can be made into a granular solid matter by a method. The k-grain method is not particularly limited, and can be exemplified. ▲ granules, fluidized bed granulation, gas H, knowing granules, stirring and finening. "Ritual granulation, extrusion granulation, compression molding granulation, granulation granulation , spray granulation or spray 乂 坆 坆 专 granules. In addition, the powdery treatment can be dissolved in a liquid, such as water, etc. ##中& Example 2, 4, 6, 8 ^ ^ ηη and 20 swimming test results, the inventors found for the first time: the thorn potato or the treatment derived from the thorns have anti-fatigue effect, endurance enhancement and According to the present invention, it is possible to provide an anti-fatigue agent containing thorny yam or yam from yam, (4) and wild yam belonging to the same family as the thorns, as shown in Comparative Example 2 below. 130108.doc -13- 200908992 Such anti-fatigue effect, financial enhancement or nourishment and strong effect, the role of the thorn is unique. X' in the following Example 7, found that the treatment of thorns or stems from yam It has an inhibitory effect on the rise of creatine kinase in the blood. It is known that creatine in the blood The enzyme is a marker that increases fatigue with exercise accompanying long-term exercise or strong muscle contraction. Further, in the following examples 15 and 15, the treatment of yam or yam pin is first found in the middle. The inhibition of lactic acid value rises. That is, the results are produced

Chemically, it has also shown that the thorny potato or the treatment derived from the yam has an endurance enhancing effect. Further, the present inventors have found that, according to the present invention, the yam or the (four)-treated material has a muscle-enhancing effect according to the present invention. According to the present invention, treatment with thorny yam or yam-derived yam can be provided. Muscle enhancer. Further, 'as another aspect of the present invention', it is possible to provide an inhibitor of creatine kinase rise in blood containing thorny potato or a treatment derived from thorny yam as an active ingredient, and an inhibitor of increasing lactic acid value in blood. In the specification of the present application, the term "fatigue" refers to a phenomenon in which the function of the muscles/nerves is excessively deteriorated, and the function is lowered. Here, the function is lowered, and the ability to work on the body and the spirit is decreased in terms of amount or f. _, means the physical fatigue after exercise such as swimming, the mental fatigue after mental work, and the physical and mental complex fatigue accumulated in social life, and is not particularly limited. Further, in the specification of the present application, fatigue refers to a state in which chronic fatigue syndrome or overwork death occurs. By anti-fatigue agent, it is meant a composition which restores and reduces fatigue conditions such as those which prevent fatigue. In this specification, the term "endurance" refers to the long-term exercise of 130108.doc 200908992. The so-called endurance enhancer means a composition that can be borrowed for a long time. In the specification of this application, s$#1u ^ is a nourishing and strong effect of the stomach, which means that by adding nutrients during mental fatigue, it can improve the self-health state such as ι or energy enhancement. Physically or mentally, the so-called nourishing and strong agent means to show such a role. In addition, the present invention provides the above-mentioned anti-fatigue agent, endurance enhancer, strongener and muscle enhancer, σ 'Lu Ming' or Feed (hereinafter, sometimes referred to as: the restaurant or feed of the month). The food or feed of the present invention is enhanced in anti-fatigue effect, endurance-enhancing effect, nourishment, or anti-fatigue, and financial strength. Use, nourish or use muscles: It is extremely useful for printing and feeding. It is used for food, food, food, food, food, food, food, food, food, food, food, food, food, food, food, food, food, food, food, food, food, food, food, food, food, food, food, food, food, food, food, food, food The above effects are extremely useful when ingested by Jiaxing. Function,... Food shows the above anti-fatigue

L is a ten-strong force, nourishing or strengthening effect, or a muscle-enhancing effect. It is especially useful for foods that are suitable for chronic fatigue, or those who accumulate fatigue or occupation, and who want to enhance endurance or muscles. In the present specification, the above-mentioned "including" means that the above-mentioned anti-fatigue agent, financial strength enhancer, nourishing two or muscle-reinforcing agent (hereinafter referred to as the preparation of the present invention) is contained in the medicine. The above-mentioned gram: the above-mentioned jin: the addition of the preparation of the present invention to the raw material of the food, the state of the raw material, refers to the aspect of the raw material in the preparation of the present invention. ..., 食食〇口 130108.doc 200908992 . For example, the method for producing a food containing or adjusting the present invention in the production of the product is not particularly limited, and the food of the present invention can be produced by a method according to a general food, such as cooking or processing. The preparation of the present invention described above may be used as a food.忭冯本 The processed product of the present invention which is obtained by the above-mentioned active ingredient of the present invention (wheat flour processed product, temple powder processed product, premix processed product, noodle, macaroni, bag, bean type) , Cai Mai noodles, wheat noodles, turn, fans, packaging cakes: oil processed products (plasticity oil, celestial oil, salad oil, egg yolk: class, seasoning oil, etc.), soybean processed products (tofu, cut, Natto, etc.): processed meat (ham, enzyme meat, pressed ham, sausage, etc.), aquatic products ("east minced meat, fish cake, bamboo wheel (cylindrical fish cake), : cake, squid balls..., fish Ham, sausage, dry work ^ canned aquatic products, shouted seafood, etc.), dairy products (raw milk, milk/fruit t two yellow:,,, condensed milk, milk powder, cream, etc.), vegetable drinks 0Γ °σ ( Shell, jam, pickles, fruit drinks, vegetables =, mixed drinks, etc.), snacks (4) East, plastic, glutinous, chocolate, Ρ biscuits 'sweet bread, cake: drink: this wine, Chinese wine, wine , Visa II, gin, rum, beer, cool alcoholic beverages, wine, etc.), hobby drinks (green tea , black tea, oolong tea, coffee, materials, lactic acid drinks, etc.), seasonings (soy sauce, sauce, vinegar red bean glutinous rice, curry, risotto, small steel mixed rice, small /, his various cooked food), half Dry or concentrated 130108.doc -16· 200908992 Food (liver sauce, other spread food, Cai Mai noodles / udon juice, concentrated soup), dry food (fast noodles, instant curry, instant coffee, juice powder, soup) Powder, instant miso soup, cooked food, cooked beverage, cooked soup, etc.), cold-bean food (chicken, steamed egg, grilled squid, hamburger patties, siu mai, dumplings, various strips, fruits) Salads, etc., solid foods, liquid foods (soups, etc.), spicy seasonings, and other agricultural and forest products, processed products, processed fish products, etc., especially for sports drinks and foods. Γ u Also, As the food of the present invention, if the preparation of the present invention contains, for example, a dry powder or an aqueous ethanol extract containing one or more of the yam, the shape is not particularly limited, and includes: a key form, a granule Shape, glue For example, when manufacturing a tablet-shaped food, it is not particularly limited as in the case of preparing a food in the form of a lozenge, as in the following Examples 1 and 11 and may be appropriately shaped. Dextrin, reduced maltose starter sugar, crystalline cellulose, micronized cerium oxide, glycerin fatty acid vinegar, lactose, maltose, sugar, powdered, plum, sucrose fatty acid vinegar, various other dietary fiber or various sugars, etc., and reused (4) The machine is manufactured by using a waste ingot. X' is not particularly limited in the case of producing a granulated food, as shown in the following Example 16. It can be used for arbor, swallowing a, the above-mentioned appropriate excipients, and various other dietary fibers. Or a variety of saccharides, etc., and it is manufactured by a granulator. Moreover, when manufacturing a capsule-shaped foodstuff, as shown in the following Examples, and the above-mentioned suitable excipients, various various dietary fiber, various sugars An emulsifier or the like is mixed to produce a hard capsule or a soft capsule. Further, as a beverage, for example, as shown in the following Example 19, the above-mentioned extract derived from 130108.doc 200908992, such as water, aqueous ethanol or ethanol extract, and various emulsifiers such as polyglycerin fatty acid ester, sucrose may be used. Fatty acid esters, mono-fatty acid esters, organic acid fatty acid esters, sorbitan fatty acid esters, propylene glycol fatty acid esters, stearyl calcium lactate, soy lecithin, egg yolk lecithin, etc., and emulsifiers are mixed. Dissolved in water to make a drink. - The content of the above-mentioned thorny yam or the stalk-derived yam in the food of the present invention is not particularly limited, and may be appropriately selected from the viewpoints of the functional and active performance, for example, in terms of dry weight, the adult is better per day. It is sufficient to take a dry powder of thorny yam in an amount of from 1 to 2000 mg/kg body weight, more preferably from 5 to 1000 mg/kg body weight, more preferably from 10 to 500 mg/kg body weight. The food or feed of the present invention may be used in combination with other ingredients which are similar to the above-mentioned anti-fatigue agent, endurance enhancer, nourishing strongener or muscle enhancer of the present invention, for example, garlic, garlic extract, egg yolk, turtle extract , Bee Sheng, Bee King Dun, Korean Man, Beef Acid, Cordyceps sinensis, Epimedium, Coenzyme Q10, Alpha Lipoic Acid, Fengweiyi, Placenta Extract, Hydroxypropylated Starch, Various Amino Acid, etc. are formulated. Further according to the present invention, there can be provided a method for producing a food containing thorny potato or a treatment derived from thorny yam, which comprises: in manufacturing, the label can be used for fatigue recovery or prevention, endurance enhancement, nourishment or muscle strengthening The steps of the intention. The term "marking can be used for fatigue recovery or prevention of endurance enhancement, nourishment or muscle augmentation", meaning that the food itself, containers, packaging and/or brochures, "marks can be used for fatigue recovery or prevention, endurance Enhancement, nourishment or muscle augmentation" 0 130108.doc 200908992 Further, the present invention provides a preparation containing the present invention, that is, containing, adding and/or diluting the preparation of the present invention, exhibiting an anti-fatigue effect, Endurance «The biological term for strong action nourishing strong action or muscle strengthening effect; = 'as another aspect' also provides a biological feeding method for administering the preparation of the present invention to a living organism. Further, as a further aspect of the present invention, a biological feeding agent characterized by the preparation of the present invention may be contained. η ο : In the specification, the creature ‘ is not limited, and examples thereof include γ, pet, and animal. As farmed animals, animals such as horses, pigs, Jinping, goats, Lu Rui, and American sharps, experimental animals such as mice, rats, guinea pigs, rabbits, chickens, ducks, turkeys, and birds, and fish can be exemplified. , crustaceans or shellfish. As a priest - #为宠物, dogs, cats, etc. can be exemplified. As a competitive animal, a competition m ^ ^ R Hummer animal feed can be exemplified, and a feed agent for maintaining and/or improving a health condition can be exemplified, and an impregnation agent, a feed, and a S (J) additive can be exemplified. , additives for beverages. According to the inventions, based on the present invention, the endurance enhancing effect, 'the anti-fatigue effect of the Ziki Xionghong or the muscle application, etc., the above-mentioned (10) "strong action" has the same effect on the food. The present invention can be expected to exhibit the insects and sa of the present invention used in the above-mentioned feed of the present invention, such as the dried wood taiwan as a thorny potato, and it is better to pass the mother's day. The mg/kg body weight, the more pregnant θ 'weight, and the better g 菫 are better than 10 〇〇 5 〇〇 will give the dry powder of the town to the target organism. For example, the second (four) heavy, the dry end is added in advance to the raw material for the object, or it is mixed with the artificial blending feed leaf i as the final raw material, 130108.doc 19· 200908992 2 added and mixed with other It is administered as a raw material. χ, the content of the preparation of the present invention in the feed is not specific, for example, as the dry core of the thorn-shaped collar, it is appropriately set to _~5 depending on the purpose. The weight = the end is preferably in the range of W3 to 20% by weight, more preferably: the method for producing the feed of the invention is not particularly limited, and the preparation method can be prepared by mixing the preparation method.

The above-mentioned effective ingredients can be ascertained. The biological feeding agent can also be prepared in the same manner. J-knife Further As the food-treating material of the present invention, it is particularly preferable to exemplify a novel composition of a thorn-water ethanol extract which is a novel food or feed. Or an aqueous ethanol extract derived from the yam of the yam. The food containing the extract or

According to the present invention, a medicine containing the preparation of the present invention (hereinafter sometimes referred to as a medicine of the present invention) can be provided. The medicine of the present invention can be used for the treatment or prevention of chronic fatigue syndrome, the nourishment of the body when the body is heavy, and the nutritional supplement when the body is tired, by virtue of its anti-fatigue, endurance enhancement, nourishment or muscle enhancement. Also, it is effective for athletes: strength enhancement or muscle reinforcement. In this case, as the administration form, the preparation of the present invention may be formulated by mixing with other medicines, or may be separately administered while being administered. The pharmaceutical of the present invention may be a preparation obtained by combining the preparation of the present invention with a well-known pharmaceutical carrier. Furthermore, in the present specification, the medical system includes quasi-drugs. Further, the pharmaceutical of the present invention, the active ingredient of the present invention of 1301〇8.d〇c 200908992, and other components which can be used for the same use as the active ingredient, are known to exhibit anti-fatigue action, endurance-enhancing effect, There are no special restrictions on the combination of other ingredients that nourish strong muscles or muscle strengthening. For example, garlic extract, turtle extract, royal jelly, Korean cuisine, bovine acid, Cordyceps sinensis, Epimedium, python, coenzyme (10) Back to α-lipoic acid, Pleurotus ostreatus, various amino acids, and the like.制造In the manufacture of the medicine of the present invention, the yam or the yam 2 treatment can be usually mixed with a pharmaceutically acceptable liquid or solid carrier, and the solvent, dispersant and emulsification can be added according to requirements. Agent, buffer, scorpion, excipient, adhesive, disintegrating agent, lubricant, etc., agent, granule, powder, powder, capsule, etc.: agent, suspension, emulsion and other liquid agents. Further, it is also possible to form a liquid dry product or other external preparation by using a suitable q agent before use. ": Music: Carrier" can be made into tablets, pills, sugars, white sugar, two fine granules, granules, etc. according to the dosage form and preparation form of the medicine. For example, it is possible to use a pharmaceutical carrier such as a powder such as a temple powder or a milk. Further, in the case of a warp, an inorganic salt mixture, a disintegrant, and an interface, it is possible to form a bond or a pill according to requirements. Or enteric (four), propyl cellulose and other sugar coatings or stomach-soluble fields, when the film of the excitable substance is used as a package, it can be made into a sucrose composition such as an oral syrup composition, such as turbidity. A solution, a suspending agent, a B%, an olive oil or the like is used as a carrier of 130108.doc 21 200908992. Further, if necessary, an auxiliary agent such as a wetting agent or a suspending agent, a sweetener, a flavoring agent, a preservative, etc. may be added.

ϋ On the other hand, in the case of a non-oral preparation, the treatment of the yam or the yam yam can be dissolved or suspended in the usual method, and used as a diluent for injection (IV) water, physiological saline, aqueous glucose solution In the case of vegetable oil for injection, sesame oil, peanut oil, soybean oil, corn oil, propylene glycol, polyalcohol, etc., a non-oral preparation is prepared by adding a bactericidal agent, a stabilizer, an isotonic agent, a soothing agent, and the like as needed. In addition, a solid implant can be made to dissolve it in sterile water or sterile (4) solvent before use: as an external preparation, including solid for administration by transdermal administration or transmucosal (intraoral, nasal, internal) , semi-solid or liquid preparations... also include: agents. For example, it can be used as an emulsion for emulsions and emulsions, for external use, etc., for liquid preparations such as liquid preparations, for oily ointments, hydrophilic ointments, etc., soft, il, film, and patch. Etc.. The temple 丄 技 予 予 或 或 予 予 丄 丄 丄 丄 丄 丄 丄 丄 丄 丄 丄 丄 丄 丄 丄 丄 丄 丄 丄 丄 丄 丄 丄 丄 丄 丄 丄 丄 丄 丄 丄 丄 丄 丄 丄 丄 丄 丄 丄 丄 丄 丄 丄❹ 有效 # # # # # # # # # # # # # # # , , , , , , , , , , , , , , , , , , , , , , , , , , , # # # # # The content of the treatment of the self-streaked yam of the present invention is not particularly limited, and for example, when using the aqueous ethanol extract of the hedgehog, the m-day is used as the thorn. 0/private in dry weight conversion, usually 1 to 100 weight / °, preferably 5 to 95% by weight, good text 疋 10 to 90% by weight left 13010S.doc • 22· 200908992 right. The present invention The medicine 'can be administered by the appropriate (4) line corresponding to the form of the preparation. For example, it can be administered by internal and external use and injection. When the therapeutic or prophylactic agent of the present invention is administered by injection, for example, it can be administered intravenously, intramuscularly, or subcutaneously. The valence of valence Ή ' can be made into a suppository for external use, for example, by using the administration method to which it is applied. The dosage of the pharmaceutical of the present invention is based on the form of the preparation, the method of administration, and the use. The purpose and the age and symptoms of the patient to be administered to the drug are appropriately set, and are not fixed. Generally, the thorn potato contained in the preparation is read or derived from the treatment of the thorn potato collar, for example, the alcohol of the thorn (4) The dosage of the dried extract of the extract is preferably (4) (9) - kg body weight, more preferably 5 to 1 mg / kg body weight, more preferably 曰 mg / kg body weight per day. μ 'dosage amount According to various articles: Ο , , , , , , , , , , , , , , , , 可 可 可 可 可 可 可 可 可 可 可 可 可 可 可 可 可 可 可 可 可 可 可 可 可 可 可 可 可 可 可 可It is divided into several times for investment. During the administration period, J is - The 'medicine of the present invention' can be added to any food directly for oral intake by direct oral administration. Further, 'the treatment of the thorn (4) used as the (four) of the present invention is particularly good. An aqueous ethanol extract of prawn can be exemplified. The aqueous smuggling is a novel composition, and thus contains the extract of the medicinal medicine. π 坎马新和' as another aspect of the present invention, can be provided including administration Stinging cockroaches or I30108.doc •23- 200908992 The method of fatigue recovery or prevention from the steps of squeezing > _ π > p pre-treatment, endurance, #t,, —,, nourish and strengthen methods Or a muscle strengthening method. Here, the administration of the hedgehog or the treatment derived from the yam may be administered to the food of the present invention or the medicine of the present invention. Further, various conditions for the administration of the yam or the yam may be carried out in accordance with the gluten revealed by the administration of the above-mentioned medicine.

U As another aspect of the present invention, a treatment which can be used for fatigue recovery or prevention, a method of prevention, an endurance enhancement method, a nourishing strong method or a muscle strengthening method, or a treatment derived from thorny potato can be provided. The thorn potato or the treatment derived from: yam may use the food of the present invention or the medical treatment of the present invention as another aspect of the present invention, and may provide an anti-fatigue agent, an endurance enhancer, a nourishing agent or a muscle strengthening The use of thorny potato in the manufacture of the agent or the use of the mashed potato treatment. According to the present invention, it is possible to provide the use of thorny potato mash or a treatment derived from thorny yam in the manufacture of foods for use in fatigue resistance, endurance enhancement, nourishment or muscle enhancement. Further, according to the present invention, it is possible to provide a puncturing town in the manufacture of medicine for anti-fatigue, endurance enhancement, nourishment, or muscle-enhancing, or a use of a treatment derived from locust. Further, as another aspect of the present invention, it is possible to provide a food or feed for use in anti-fatigue, endurance-enhancing, nourishing or muscle-strengthening, which is characterized by the treatment of yam or yam. As the food or the feed, for example, a food with a label indicating that fatigue recovery or pre-endurance enhancement, nourishment or muscle enhancement can be exemplified can be exemplified. $ or feed. 130108.doc -24- 200908992 The thorn potato collar used in the present invention or the treatment derived from the thorn potato collar has no toxicity even if it is administered to the organism to exhibit an effective amount of its action. [Example 1] Preparation of dried yam yam powder From the shop of Okinawa Prefecture, the squid diarrhea was purchased (Di〇sc〇rea e_ie was about 370 kg. It was cut into slices having a thickness of about 5 _, and heated under

2H, at this time, drying is performed by this. Among them, about 7 was subjected to far-infrared treatment (12 (TC, 7 to 8 minutes), and then pulverized to obtain 6 kg of powder. [Example 2] Evaluation of anti-fatigue effect of prawn powder was purchased from SLC Corporation of Japan Human male ICR mice were used for experiments from 6 weeks after preparation for feeding. The yam powder prepared in Example 1 was mixed at a ratio of: rod) to standard feed ce_2 (manufactured by Japan (5) Co., Ltd.) And make test feeds. Pre-selected: 斿) Individuals above the time, and distributed them equally to each group before the test feed was administered. Thereafter, on the 7th day, the 8th day, and the ninth day, the test group of the free-intake test feed and the swimming test group of the control group of the standard feed CE_2 freely ingested were measured for comparison. The swimming time is forced to swim from the weight of the mouse, which is 1% of the weight and weight of the mouse. When the fatigue causes the head of the mouse to completely sink into the water for 5 seconds, the group of 23 is flat. The soil standard error (minutes) is shown in Table 1. As a result, it can be seen that the swimming time has been prolonged since the 7th day from the start of the test feed and self-technical. In addition, the changes in body weight and food intake during the period were not abnormal, and it was found that it could be taken safely. 130108.doc -25- 200908992 [Table 1] Swimming time (minutes) On the 7th day after the start of the administration, the 8th day after the start of the administration, the 9th day after the start of the control group, the feed group was 19.4±1.2 21.5±1.2. 17.111.1 20.7+1.2 16.9±1.0 20.5+1.3 [Example 3] Preparation of 70% (v/v) ethanol extract of yam yam. The dried yam powder prepared in Example 1 was stirred while stirring. After adding to 2 L of 70% (v/v) ethanol, the mixture was stirred at 25 ° C for 24 hours using a stirrer, and then suction-filtered using a Buchner funnel (filter paper No. 2, manufactured by Wattmann). The filtrate was evaporated to dryness using an evaporator to obtain a 70 〇/〇 (v/v) ethanol extract of 19.02 g. The 70% (v/v) ethanol extract was mixed into a standard powder feed CE-2 (manufactured by Clea Co., Ltd.) to make an equivalent amount of 1% (w/w) mixed feed of the dried yam powder, and the test was made. feed. [Example 4] Evaluation of anti-fatigue action of 70% (v/v) ethanol extract of yam potato The male ICR mouse was purchased from SLC Corporation of Japan, and the swimming time was measured in the same manner as in Example 2. The mice of the test group in the present example were allowed to freely ingest the test feed prepared in Example 3 one week before the measurement of the swimming exercise time. The results of the 7th day of the start of administration were taken as the average value of each group; t standard error (minutes) is shown in Table 2. As a result, it was found that the swimming time of the 7〇% (v/v) ethanol extract administered to the group was prolonged. On the other hand, there was no abnormal change in body weight and food intake during the period of administration, and it was known to be safe to take. B0108.doc -26- 200908992 [Table 2] ___-_Change thin room (minutes) Control group 19.2±1.7 70% (v/v) ethanol extract administration group ___ 23,2+1,6 [Implementation Example 5]

The propylene-extracted component of the self-streaked yam 7 〇〇/g (v/v) ethanol extract was prepared in 7% by weight (v/v) ethanol extract of 5.031 g of the yam yam prepared in Example 3. 300 mL of acetone was added and suspended, and centrifuged at 56 Torr > g for 20 minutes. The supernatant was evaporated to dryness using an evaporator to obtain 245 mg of the acetone extract of yam. The C-extract was mixed into a standard powder feed CE-2 (manufactured by Sakamoto Clea Co., Ltd.), and mixed with a mashed dried yam dry powder 1% (w/w) to prepare a test feed. [Example 6] Evaluation of anti-fatigue effect of the acetaminophen-extracted component of 70% (v/v) ethanol extract of sphagnum chinensis from Japanese SLC male (four) w male leg mice, and swimming was measured in the same manner as in Example 2. time. The mice of the test group in the present example were allowed to freely ingest the test feed prepared in Example 5 from the time of measuring the swimming exercise time one week ago. The results of the 8th day from the start of administration were shown as Table 3 in the mean value ± standard error (minutes) of 9 groups. The results show that the swimming time of the extracting group has been extended. On the other hand, there was no abnormality in the changes in body weight and food intake during the administration period. 130108.doc -27- 200908992 [Table 3] ~~ Swimming time (minutes) Control group 17.5+1.8 Acetone extract administration group _23.3±2.1_ [Example 7] Biochemical evaluation of anti-fatigue effect of prawn powder A male ICR mouse was purchased from SLC Corporation of Japan, and a test feed was prepared by mixing the yam powder into a standard feed CE-2 at a ratio of 1% (w/w) in the same manner as in Example 2, and was administered. The day after the r'.'\ swimming test was carried out on the 7th to the 9th day, that is, on the 10th day after the start of the test feed administration, the weight of the mouse was loaded with 1 °/〇 (w/w) of the body weight, and After 10 minutes of forced swimming, blood was collected. The creatine kinase value in the blood was measured using DRICHEM (manufactured by FUJIFILM Co., Ltd.). Also, the group that is not forced to swim is set as an unprocessed group. The average soil standard error (U/L) of each group is shown in Table 4. The value of creatine kinase in the control group was higher than that of the untreated group due to the accumulation of fatigue caused by swimming in the past few days. In contrast, the test feed group showed the same degree as the untreated group. [Table 4] Creatine kinase value (U/L) Control group (N=7) 555.6 Test feed administration group (N=5) 212.0 Untreated group (N=16) 264.0 [Example 8] Self-streaked yam 70 Evaluation of the anti-fatigue effect of the acetone extract component of the % (v/v) ethanol extract (dosage-dependent) 130108.doc -28- 200908992 The c-extract was prepared in the same manner as in Example 5. These were mixed into a standard powder feed CE_2 (manufactured by Clea Corporation, Japan) to prepare test feeds. The amount of the dose was the same as that of the dried yam, dry powder, / (four), mixed feed. The male ICR mouse was purchased from 曰sl company, and the swimming time was measured in the same manner as in Example 2. In the present example, the group = group of mice (2 groups) was used since the measurement of swimming (1) weeks ago.

As for the results from the 7th day to the 9th day of the start of the experiment, the standard deviation (minutes) of the average value of the 8th of each group is shown in Table 5. As a result, it can be seen that the dose of the extract of the cockroach extract is It can extend the swimming time. The other party can take it safely. The change in food intake is not abnormal. It is known [Table 5]

3% (w/w) equivalent) Acetone extract was administered to group 244+1r (with diced dried yam dry powder·_·8 26·9±1.3 26.9±1.3 10% (w/w) equivalent) [Examples] 9] Evaluation of 7萃% (v/v) ethanol extraction from self-streaked yam (forced oral administration) Anti-fatigue of extracted components: In the same manner as in Example 5, the concentration was adjusted to be less ^To the heart of ethanol (made by Putian Chemical Co., Ltd. 4 I30I08.doc •29·200908992), the concentration of ethanol reached 1% (v/ (Wako Pure Chemical Industries Co., Ltd., added to the olive oil media system) A uniform solution was prepared in such a manner as to achieve 10% (v/v). The sexual ICR mouse was purchased from Japan SLC Co., Ltd., and the ethanol was used to determine the swimming time. The test in this example; Life=The system will adjust the sample of f in the above way, on the first day, A (group), year "zhe":: You, - people, day 2, day 3, day 9, day 8, ninth Forcibly orally administered by the day. The average of the groups of 6 to 1 - - standard 2: : D, ° results can be seen, if the cockroach extract is forced to π, it can extend the swimming time, if increased Amount of investment Time. On the other hand, the weight during the period of the second period:: prolonged swimming, abnormal, known to be safe to take. And the change in food intake is not [Table 6]

"^子照群" ----- swimming time (minutes) vehicle administration group 11_2±0.9 11.2±3.7 12.210.9 Acetone extract (about 24 mg/kg) is administered to the group (with thorn potato collar) Dry powder 3% (w/w) equivalent) 14.M2.2 [Example 10] According to the composition of Table 7 below, using a tablet press, the pressure at the time of pressing is 1000 kg/cm2, A usual method is to prepare a lozenge (250 mg/ingot) containing a dried powder of yam. Further, the mixing system is carried out in one mixing and two times, and then ingot is pressed. 130108.doc • 30- 200908992 [Table 7] Ingredients _ mg/1 bond Once mixed Prickly ash dried powder (sterilized) Dextrin Reduced maltose saccharide Crystalline cellulose Pb2

150 29.75 32.75 25 2.5 Secondary mixed particulate ceria 2.5 Glycerol fatty acid ester 7.5 Total 250 [Example 11] According to the composition of Table 8 below, a tablet press was used, and the pressure at the time of pressing was 1000 kg/cm 2 . A lozenge (250 mg/ingot) containing a dried powder of thorny yam was prepared according to the usual method. Further, the mixing system is carried out in one mixing and two times, and then ingot is pressed. [Table 8] Ingredient _ mg/1 key One time mixing

150 8.5 8.3 1.7 12.5 31.5 25.0 5.0 Prickly ash dried powder (sterilized) Pure royal jelly powder Korean cockroach extract powder Garlic extract Powder dextrin reduction maltose saccharide crystalline cellulose granules cerium dioxide secondary mixed glycerol fatty acid ester 7.5 Total 250 130108.doc -31 - 200908992 [Example 12] Preparation of 60% (v/v) ethanol extract of yam yam - face-to-face mixing - The dry powder of prawn prepared by (4) will be implemented § § Add to 8 L of 60 In % (v/v) ethanol, the mixture was stirred for 24 hours at 25° using a stirrer, and suction filtration was carried out using a Buchner funnel (filter paper N〇2, manufactured by __). The filtration and liquid systems were evaporated to dryness using an evaporator to obtain a 90% (v/v) ethanol extract of 98.9 g. [Example 13]

Evaluation of Anti-fatigue Effect of 60% (v/v) Ethanol Extract of Pleurotus ostreatus Male ICR mice were purchased from SLC Corporation of Japan, and swimming time was measured in the same manner as in Example Ice. The mouse of the test group in the present example was subjected to the ratio of 'free intake to 1% by weight (w/w) equivalent to the prawn powder 1 week before the swimming exercise time was measured, and the ratio in Example 12 was used. The prepared 6G% (v/v) ethanol extract was mixed with a standard powder feed (manufactured by Clea & Co., Ltd.). The average value ± standard error (minutes) of each group I or the group η is shown in Table 9 on the 7th and 8th days after the start of the administration. The results show that the ethanol extract is cast. The swimming time of the group has been prolonged. On the other hand, the changes in body weight and food intake during the period of administration have not been abnormal, and it is known to be safe to take. [Table 9] (minutes)

Control group alcohol extract administration group 130108.doc -32- 200908992 [Example 14] Effect of prawn powder administration on lactic acid value in blood Male ICR mice were purchased from Japanese SLC company, and modulated at 3% (w/ w) Ratio The test feed obtained by mixing the yam powder prepared in Example 1 into the standard feed CE_2 was administered. On the 7th and 8th days, swimming was carried out until fatigue caused the head to sink completely into the water for 5 seconds. After 5 minutes of swimming on the 9th day, blood was collected from the abdominal vein immediately under anesthesia. The lactic acid value in the blood was measured using a lactic acid measuring device Lactate Pr® (manufactured by Arkray Co., Ltd.). Further, the group that has not performed swimming is set as an unprocessed group. The mean value ± standard error (mm 〇 l / L) of each group is shown in Table 10. The lactic acid value in the blood of the control group showed a high value, whereas the prawn powder administration group was lower than the control group. [Table 10] Lactic acid value (mmol/L) ~9^4±1.3 (Ν=9) 7.5±0.6 (Ν=10) 2.0±0.3 (Ν=7) Control group

Powder 3% (w/w) was administered to the untreated group [Example 15] 60% (v/v) ethanol extract of yam yam was administered to Japanese SLC company for the lactic acid value in the heart and night, and male ICR mice were purchased. The test feed obtained by mixing the cesium (IV) ethanol extract prepared in Example η into the standard feed CE_2 at a ratio of (iv) (w/W) (equivalent to 3% (w/w) of the powder) was introduced into W. Swimming was performed in the same manner as in Example 14, and blood was collected immediately after the 5-minute swimming exercise on the 9th day, and the lactic acid value in the blood 130I08.doc - 33 - 200908992 was measured. Further, the group in which no swimming exercise is performed is set as an unprocessed group. The average soil standard error (mmol/L) of each group is shown in Table 11. The lactic acid value in the blood of the control group showed that the extracting group was lower than the control group [Table 11], whereas the ethanol extract of the yam yam was (mmol/L) and the control group was 7.5±0.4 (N). =9) Ethanol extract administration group 6·5±0.7 (Ν=9) Untreated group 2.5±0.4 (Ν=10) [Example 16] An extrusion granulator was used according to the composition of Table 12 below. (1.0 mm net), according to the usual method, a granule containing a dried powder of yam. That is, after kneading, granulation, and drying, the granules are granulated to produce granules. [Table 12] Ingredient mg/3000 mg Dried yam powder (sterilized) 1800 Trehalose 500 Lactose 400 Crystalline cellulose 180 Sucrose fatty acid ester 120 [Example 17] According to the composition of Table 13 below, according to the usual method, A hard capsule containing a dried powder of yam. That is, after mixing 1 and 2 times of mixing, the mixture was filled to prepare a hard capsule. 130108.doc •34- 200908992 [Table 13]

100 thorny yam dry powder (sterilized) - described .................................. Sucrose fatty acid ester talc powder _ [Example 18] J80.6 .....---------------

Ο

According to the composition of Table 14 below, an elliptical type 6 soft capsule containing a punctured dry powder was prepared according to the usual method. That is, after the chemical solution is prepared, pulverized, and defoamed, it is filled and dried to produce a soft capsule. [Table 14] Ingredient mg/Ι capsule, yam yam dry powder (sterilized) 1 〇〇 - rice salad oil 150 glycerin fatty acid ester 25 beeswax 25 - total ~ ~ 300 [Example 19] Drying thorns while drying Add 8 μg of powder to 8 l of 60% ethanol by using a stirrer at 25. After stirring under stirring for 24 hours, a filtrate of 7.38 L was obtained by suction filtration. Thereafter, an emulsifier (SYGlyster MM-750: Sakamoto Pharmaceutical Co., Ltd.) 1 g ' was added to 100 mL to concentrate with a rotary evaporator, and the solvent was removed. Water was added to the solvent-removed extract to prepare it. 1 〇〇mL, and obtain the yam yam emulsion. According to the composition of Table 15 below, according to the usual method, 130108.doc -35-200908992 beverage containing mashed potato mash emulsion is prepared. That is, after mixing, filling, sterilizing And making a drink. [Table 15]

Prickly ash emulsion Instantly heat sterilization honey BK-1 Grapefruit juice Grapefruit extract No.80 Vitamin C 10 7 3 0.1 0.1

Too [Embodiment 20]

Effect of long-term administration of prawn powder and extract on regular exercise 1 Japanese SLC company purchased male BALB/c mice, which were used for experiment 7 weeks after preparation. A test feed was prepared by mixing the yam powder prepared in Example i into a standard feed CE_2 (manufactured by Clea Corporation, Japan) at a ratio of 1% (w/w). Further, a test feed obtained by mixing 60% (V/V) ethanol extract prepared in Example 12 into a standard powder sample CE-2 was also used. Before the test feed is administered, individuals who can swim for more than a certain period of time are pre-selected and distributed equally among the groups. Thereafter, a test group in which the test feed is freely taken and a control group in which the standard feed CE_2 is freely ingested are set, and the test feed is administered on the third day to be the first time once a week, and the ice is exercised until fatigue occurs. The mouse's head was completely sunk into the water for $ seconds. On the 1st to 5th week, the time until the head of the mouse completely sank into the water for 5 seconds was measured. The swimming exercise was carried out in the same manner as in the second embodiment. The average soil standard error (minutes) of each group of 11 to 15 is shown in the table. Compared with the control group, the test copper material mixed with prawn powder 1% (w/w) and mixed 130108.dc -36- 200908992 Into the secret (10)) In the test feed of the material of the material, it can be seen that the swimming time is longer than the time of the swimming, and the change in the food intake during the feeding period is not abnormal.

[Table 16]

After the start of the third week, the first week of M ± 〇 7 73.7 + 0.9 Π .0 ± 0.8 Week 5 control powder l% (w / w) 60% ethanol extract 1.5% (w / w) [Example 21 The effect of long-term combination of prawn powder and extract on regular exercise 2 7.1±0.4 10.0±0.5 9.1±0.4 6.7±0.4 9.2±0.58.8±0.6

Male BALB/c mice were purchased from SLC Corporation of Japan and used for experiments from the age of 7 weeks after preparation. The same experiment as in Example 2 was carried out, and the swimming exercise was carried out at the 8th week of the test feed until the head of the mouse was completely sunk into the water for 5 seconds, and the next day, the mice were bled and anesthetized under anesthesia. . The gastrocnemius and soleus muscles of the right hind limb were removed and the reset was measured. Also, the fat around the testis was taken out and the weight was measured. The average value of each group of 9 to 丨5 is shown in Table 17. Compared with the control group, the 1% (w/w) and 60ο/〇(ν/ν) ethanol extracts of the yam powder were administered to the group, and an increase in the amount of muscle was observed. On the other hand, the amount of fat was reduced in the group of the yam powder 1% (w/w) and 60% (v/v) ethanol extract. 130108.doc -37- 200908992 [Table 17]

Wild mountain yam powder is prepared with wild yam (DiOSC〇rea jap〇nica) (produced in Japan after Kyotan), cut into slices of thickness 2~3. After the slices are dried at 6〇t for 5 hours, The pulverization was carried out using a small ultra-high speed pulverizer (manufactured by Dai E Chemical Co., Ltd.) to obtain 214.3 9 g of wild yam powder. [Comparative Example 2] Evaluation of the anti-fatigue effect of wild yam administered to mice. In the ICR mice, the swimming time was measured in the same manner as in Example 2. The mice of the test group in the present example were allowed to freely ingest the test feed prepared in the control (6) from the week before the measurement of the swimming exercise time. The results of the 7th day of the start of the administration were as the average of 9 in each group, and the value was corrected (divided in Table 18. The result was that the swimming time was not observed for the pure white yam.) 18] Between (minutes) 18.8+2.0 19.0+1.9 Control group wild yam administration group [Industrial availability] I30108.doc -38- 200908992 According to the present invention, treatment with yam or yam may be provided. Anti-fatigue as an active ingredient , an endurance enhancer, a nourishing strongener or a muscle-enhanced food, feed or medicine containing the preparation, and an extract derived from the yam and the preparation of the extract, and the method for producing the extract Agents, endurance enhancers, nourishing strong (4) or muscle enhancers, not only can improve the athlete's ability, but also can be used as a food or medicine material with fatigue recovery effect in social life. \ β 130108.doc •39-

Claims (1)

200908992 X. Patent application scope:]· An anti-fatigue agent, endurance-enhancing sword, and Lomo sub-agent, which contain thorny yam or derived from thorns and strong muscles or muscle-enhanced, self-piercing pre-treatments as effective 2 An anti-fatigue agent, an endurance enhancer, a meat enhancer of claim 1, which is derived from a thorn potato borrowing strongener or a muscle L· m > ^ k 7 ir treatment dry powder, water, ethanol, Aqueous ethanol or acetonitrile extract. 'A group obtained from the extract 3. A food or feed, which is a combination of an anti-fatigue agent, a strong nourishing agent, a natural anti-fatigue agent, or a muscle enhancer. A medicine containing an anti-fatigue agent such as a requesting agent, nourishing + or 2, an endurance-enhancing hl / zychotrophic agent or a muscle-reinforcing agent. 5. - Method for producing extracts The steps of extracting with aqueous ethanol or acetone. (4) 蓣 with water, ethanol, 6. The manufacturing method of claim 5, ethanol. The stalk is known to be 1 to 85% (v/v) aqueous. 7. The extract can be obtained by the method of 8 - ^ ^ σ . ^ ruler 5 or 6. • A food that contains, as claimed, a medicine containing an extract such as & s Stroke, 3, and No. 7. 10. A kind of fatigue recovery or pre-mortem ancient method, soil method A m θ μ /, endurance enhancement method, nourishing strong method sub-muscle enhancement method, i # ^ ^ I® 4A, 奴奴予刺蓣 or derived from 刺The steps of the pretreatment. U· A thorny yam or a stalked yam 蓣 π Iπ + pre-treatment, which is used in the prevention of fatigue recovery methods. Endurance increase, method, nourish strong method or muscle 130108.doc 200908992 Enhancement method. I2. Manufacture of foods containing thorny yam or yam-derived yam, 11 'in the manufacturing, including signs for fatigue recovery or prevention, endurance 2A, a strong, nourishing strong or muscle strengthening A step of. 130108.doc 200908992 VII. Designated representative: (1) The representative representative of the case is: (none) (2) The symbol of the symbol of the representative figure is simple: 8. If there is a chemical formula in this case, please reveal the best indication of the characteristics of the invention. Chemical formula: (none) 130108.doc