JP2005539026A - 形質転換成長因子のピラゾール阻害剤 - Google Patents
形質転換成長因子のピラゾール阻害剤 Download PDFInfo
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- JP2005539026A JP2005539026A JP2004528450A JP2004528450A JP2005539026A JP 2005539026 A JP2005539026 A JP 2005539026A JP 2004528450 A JP2004528450 A JP 2004528450A JP 2004528450 A JP2004528450 A JP 2004528450A JP 2005539026 A JP2005539026 A JP 2005539026A
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Classifications
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- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
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- Medicinal Chemistry (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Hospice & Palliative Care (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0217786.3A GB0217786D0 (en) | 2002-07-31 | 2002-07-31 | Compounds |
| PCT/EP2003/008449 WO2004016606A1 (en) | 2002-07-31 | 2003-07-29 | Pyrazole inhibitors of the transforming growth factor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005539026A true JP2005539026A (ja) | 2005-12-22 |
| JP2005539026A5 JP2005539026A5 (https=) | 2006-09-14 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004528450A Pending JP2005539026A (ja) | 2002-07-31 | 2003-07-29 | 形質転換成長因子のピラゾール阻害剤 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20060058329A1 (https=) |
| EP (1) | EP1554268A1 (https=) |
| JP (1) | JP2005539026A (https=) |
| AU (1) | AU2003255333A1 (https=) |
| GB (1) | GB0217786D0 (https=) |
| WO (1) | WO2004016606A1 (https=) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009543765A (ja) * | 2006-07-14 | 2009-12-10 | ノバルティス アクチエンゲゼルシャフト | Ａｌｋ−５阻害剤としてのピリミジン誘導体 |
| JP2011509278A (ja) * | 2008-01-11 | 2011-03-24 | ノバルティス アーゲー | キナーゼ阻害剤としてのピリミジン類 |
| JP2023509760A (ja) * | 2020-01-08 | 2023-03-09 | シンシス セラピューティクス，インコーポレイテッド | Ａｌｋ５阻害剤複合体およびその使用 |
| US12473377B2 (en) | 2016-01-14 | 2025-11-18 | Synthis Therapeutics, Inc. | Antibody-ALK5 inhibitor conjugates and their uses |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| JP2006522130A (ja) * | 2003-04-03 | 2006-09-28 | メルク エンド カムパニー インコーポレーテッド | ナトリウムチャンネル遮断薬としてのビアリール置換ピラゾール |
| US20060063208A1 (en) | 2004-08-02 | 2006-03-23 | Woolf Clifford J | DRG11-responsive (DRAGON) gene and uses thereof |
| TW200639163A (en) * | 2005-02-04 | 2006-11-16 | Genentech Inc | RAF inhibitor compounds and methods |
| US7968091B2 (en) | 2005-02-16 | 2011-06-28 | The General Hospital Corporation | Methods and compositions to regulate iron metabolism |
| AU2006239929B2 (en) | 2005-04-22 | 2011-11-03 | Alantos Pharmaceuticals Holding, Inc. | Dipeptidyl peptidase-IV inhibitors |
| DK2083863T3 (da) | 2006-10-03 | 2015-06-22 | Genzyme Corp | Antistoffer mod tgf-beta til anvendelse til behandling af spædbørn med risiko for udvikling af bronkopulmonal dysplasi |
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| WO2009089324A1 (en) | 2008-01-08 | 2009-07-16 | Yale University | Compositions and methods for promoting patency of vascular grafts |
| JP6018753B2 (ja) | 2008-11-13 | 2016-11-02 | ザ・ジェネラル・ホスピタル・コーポレイションＴｈｅ Ｇｅｎｅｒａｌ Ｈｏｓｐｉｔａｌ Ｃｏｒｐｏｒａｔｉｏｎ | Ｂｍｐ−６の調節によって鉄の恒常性を制御するための方法および組成物 |
| AR081810A1 (es) | 2010-04-07 | 2012-10-24 | Bayer Cropscience Ag | Piridinilpirazoles biciclicos |
| AR088020A1 (es) | 2010-06-30 | 2014-05-07 | Ironwood Pharmaceuticals Inc | Compuestos heterociclicos como estimuladores de sgc |
| EP2637659B1 (en) | 2010-11-09 | 2016-05-18 | Ironwood Pharmaceuticals, Inc. | Sgc stimulators |
| US9446175B2 (en) | 2011-06-03 | 2016-09-20 | Yale University | Compositions and methods for treating and preventing neointimal stenosis |
| US20140308275A1 (en) | 2011-07-27 | 2014-10-16 | Inserm (Institut National De La Sante Et De La Recherche Medicale | Methods for diagnosing and treating myhre syndrome |
| WO2013062544A1 (en) | 2011-10-26 | 2013-05-02 | Seattle Children's Research Institute | Cysteamine in the treatment of fibrotic disease |
| CN106117194A (zh) | 2011-12-27 | 2016-11-16 | 铁木医药有限公司 | 可用作sgc刺激剂的2‑苄基、3‑(嘧啶‑2‑基)取代的吡唑类 |
| CA3007631A1 (en) | 2015-12-11 | 2017-06-15 | Research Institute At Nationwide Children's Hospital | Optimized patient specific non-linear tissue engineered vascular grafts |
| JP2022527972A (ja) | 2019-04-02 | 2022-06-07 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 前悪性病変を有する患者において癌を予測及び予防する方法 |
| EP4556478A4 (en) * | 2022-08-08 | 2025-10-22 | Medinno Pharmaceutical Tech Zhuhai Co Ltd | TGF-BETA INHIBITOR COMPOUND AND USE THEREOF |
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| US6514977B1 (en) * | 1997-05-22 | 2003-02-04 | G.D. Searle & Company | Substituted pyrazoles as p38 kinase inhibitors |
| PL337020A1 (en) * | 1997-05-22 | 2000-07-31 | Searle & Co | Substituted pyrazoles as kinase p38 inhibitors |
| GB0027987D0 (en) * | 2000-11-16 | 2001-01-03 | Smithkline Beecham Plc | Compounds |
| WO2002062787A1 (en) * | 2001-02-02 | 2002-08-15 | Glaxo Group Limited | Pyrazoles as tgf inhibitors |
| JP2004521915A (ja) * | 2001-02-02 | 2004-07-22 | グラクソ グループ リミテッド | Ｔｇｆ過剰発現に対するピラゾール誘導体 |
-
2002
- 2002-07-31 GB GBGB0217786.3A patent/GB0217786D0/en not_active Ceased
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2003
- 2003-07-29 US US10/522,970 patent/US20060058329A1/en not_active Abandoned
- 2003-07-29 EP EP03787752A patent/EP1554268A1/en not_active Withdrawn
- 2003-07-29 WO PCT/EP2003/008449 patent/WO2004016606A1/en not_active Ceased
- 2003-07-29 JP JP2004528450A patent/JP2005539026A/ja active Pending
- 2003-07-29 AU AU2003255333A patent/AU2003255333A1/en not_active Abandoned
Cited By (4)
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|---|---|---|---|---|
| JP2009543765A (ja) * | 2006-07-14 | 2009-12-10 | ノバルティス アクチエンゲゼルシャフト | Ａｌｋ−５阻害剤としてのピリミジン誘導体 |
| JP2011509278A (ja) * | 2008-01-11 | 2011-03-24 | ノバルティス アーゲー | キナーゼ阻害剤としてのピリミジン類 |
| US12473377B2 (en) | 2016-01-14 | 2025-11-18 | Synthis Therapeutics, Inc. | Antibody-ALK5 inhibitor conjugates and their uses |
| JP2023509760A (ja) * | 2020-01-08 | 2023-03-09 | シンシス セラピューティクス，インコーポレイテッド | Ａｌｋ５阻害剤複合体およびその使用 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1554268A1 (en) | 2005-07-20 |
| WO2004016606A1 (en) | 2004-02-26 |
| US20060058329A1 (en) | 2006-03-16 |
| AU2003255333A1 (en) | 2004-03-03 |
| GB0217786D0 (en) | 2002-09-11 |
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