JP2005538155A - 非ヌクレオシド逆転写酵素インヒビター - Google Patents
非ヌクレオシド逆転写酵素インヒビター Download PDFInfo
- Publication number
- JP2005538155A JP2005538155A JP2004533489A JP2004533489A JP2005538155A JP 2005538155 A JP2005538155 A JP 2005538155A JP 2004533489 A JP2004533489 A JP 2004533489A JP 2004533489 A JP2004533489 A JP 2004533489A JP 2005538155 A JP2005538155 A JP 2005538155A
- Authority
- JP
- Japan
- Prior art keywords
- mmol
- cis
- difluoro
- alkyl
- tetrahydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 0 *[C@](CC1)[C@]1N Chemical compound *[C@](CC1)[C@]1N 0.000 description 6
- MYGGZFBZQAXAFB-UHFFFAOYSA-N C#Cc1ccc(C(C2CC3)C2C(O)=O)c3c1 Chemical compound C#Cc1ccc(C(C2CC3)C2C(O)=O)c3c1 MYGGZFBZQAXAFB-UHFFFAOYSA-N 0.000 description 1
- ONJRTQUWKRDCTA-UHFFFAOYSA-N C1Sc(cccc2)c2C=C1 Chemical compound C1Sc(cccc2)c2C=C1 ONJRTQUWKRDCTA-UHFFFAOYSA-N 0.000 description 1
- JWSWGVMVRLVNAA-UHFFFAOYSA-N C1c2ccccc2SC=C1 Chemical compound C1c2ccccc2SC=C1 JWSWGVMVRLVNAA-UHFFFAOYSA-N 0.000 description 1
- AURRUKAYROQZJM-UHFFFAOYSA-N C=[OH]=C1c2ccccc2SCC1 Chemical compound C=[OH]=C1c2ccccc2SCC1 AURRUKAYROQZJM-UHFFFAOYSA-N 0.000 description 1
- JOXFVWGHNMYWMK-UHFFFAOYSA-N CC(c(ccc(OCC#C)c1)c1O)=O Chemical compound CC(c(ccc(OCC#C)c1)c1O)=O JOXFVWGHNMYWMK-UHFFFAOYSA-N 0.000 description 1
- CPGYSXCJYFRARD-UHFFFAOYSA-N CCC(c(c(OCC#C)c1)ccc1F)=O Chemical compound CCC(c(c(OCC#C)c1)ccc1F)=O CPGYSXCJYFRARD-UHFFFAOYSA-N 0.000 description 1
- FLHOJYDOUKXBNH-UHFFFAOYSA-N CCC(c1ccc2OCC=Cc2c1O)=O Chemical compound CCC(c1ccc2OCC=Cc2c1O)=O FLHOJYDOUKXBNH-UHFFFAOYSA-N 0.000 description 1
- LEYDLBCEHUAAPZ-QEWOUOOISA-N CCOC([C@H]1C2c(cccc3)c3SCC12)=O Chemical compound CCOC([C@H]1C2c(cccc3)c3SCC12)=O LEYDLBCEHUAAPZ-QEWOUOOISA-N 0.000 description 1
- RUKQMUCMWAMVCY-AZUAARDMSA-N Cc(cc1)c([C@@H](C2)[C@@H]2NC(Nc2ccc(Cc3cccc(F)c3)cn2)=S)c(OC)c1F Chemical compound Cc(cc1)c([C@@H](C2)[C@@H]2NC(Nc2ccc(Cc3cccc(F)c3)cn2)=S)c(OC)c1F RUKQMUCMWAMVCY-AZUAARDMSA-N 0.000 description 1
- QMKXIHSGSUGVEE-UHFFFAOYSA-N Fc(c1c2OCC=C1)ccc2Br Chemical compound Fc(c1c2OCC=C1)ccc2Br QMKXIHSGSUGVEE-UHFFFAOYSA-N 0.000 description 1
- VAISPIZMPVMXTC-MAUKXSAKSA-N N#Cc(cc1)ccc1Oc(cc1)cnc1NC(N[C@H](C1)[C@H]1c(c(F)ccc1F)c1O)=O Chemical compound N#Cc(cc1)ccc1Oc(cc1)cnc1NC(N[C@H](C1)[C@H]1c(c(F)ccc1F)c1O)=O VAISPIZMPVMXTC-MAUKXSAKSA-N 0.000 description 1
- OJBRQBOJUAXVLU-UHFFFAOYSA-N N#Cc1ccc(C(C2C3)C2C(O)=O)c3c1 Chemical compound N#Cc1ccc(C(C2C3)C2C(O)=O)c3c1 OJBRQBOJUAXVLU-UHFFFAOYSA-N 0.000 description 1
- KQPXZNHMXPKRKN-UHFFFAOYSA-N Nc(cc1)ncc1Oc1cccc(C#N)c1 Chemical compound Nc(cc1)ncc1Oc1cccc(C#N)c1 KQPXZNHMXPKRKN-UHFFFAOYSA-N 0.000 description 1
- IJGPKYNRLWOYJT-UHFFFAOYSA-N Nc(nc1)ccc1OCCN1CCOCC1 Chemical compound Nc(nc1)ccc1OCCN1CCOCC1 IJGPKYNRLWOYJT-UHFFFAOYSA-N 0.000 description 1
- PPNDVQGPAPLJNH-UHFFFAOYSA-N OC(C(C1C2)C1c1c2cccc1)=O Chemical compound OC(C(C1C2)C1c1c2cccc1)=O PPNDVQGPAPLJNH-UHFFFAOYSA-N 0.000 description 1
- PQGXDFMRRVWIHH-UHFFFAOYSA-N OC(C(C1CCC2)C1c1c2cccc1)=O Chemical compound OC(C(C1CCC2)C1c1c2cccc1)=O PQGXDFMRRVWIHH-UHFFFAOYSA-N 0.000 description 1
- WFEGNTSZTMKNFT-UHFFFAOYSA-N OC(C1C2Sc3ccccc3C12)=O Chemical compound OC(C1C2Sc3ccccc3C12)=O WFEGNTSZTMKNFT-UHFFFAOYSA-N 0.000 description 1
- FWVSZXYNCFXKRT-UHFFFAOYSA-N OC1c2ccccc2SCC1 Chemical compound OC1c2ccccc2SCC1 FWVSZXYNCFXKRT-UHFFFAOYSA-N 0.000 description 1
- GLAVJHREMSPNGK-UHFFFAOYSA-N [O-][N+](c(cc1)ncc1Oc1cc(F)c(CN2CCOCC2)cc1)=O Chemical compound [O-][N+](c(cc1)ncc1Oc1cc(F)c(CN2CCOCC2)cc1)=O GLAVJHREMSPNGK-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- AIDS & HIV (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Pyridine Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02019997 | 2002-09-05 | ||
| PCT/EP2003/009872 WO2004021969A2 (en) | 2002-09-05 | 2003-09-05 | Non-nucleoside reverse transcriptase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005538155A true JP2005538155A (ja) | 2005-12-15 |
| JP2005538155A5 JP2005538155A5 (https=) | 2006-07-20 |
Family
ID=31970278
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004533489A Withdrawn JP2005538155A (ja) | 2002-09-05 | 2003-09-05 | 非ヌクレオシド逆転写酵素インヒビター |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7517992B2 (https=) |
| EP (1) | EP1534276B1 (https=) |
| JP (1) | JP2005538155A (https=) |
| KR (1) | KR20050033663A (https=) |
| CN (1) | CN1694700A (https=) |
| AT (1) | ATE413174T1 (https=) |
| AU (1) | AU2003260492B2 (https=) |
| CA (1) | CA2501924A1 (https=) |
| DE (1) | DE60324568D1 (https=) |
| MX (1) | MXPA05002545A (https=) |
| WO (1) | WO2004021969A2 (https=) |
| ZA (1) | ZA200501805B (https=) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016523270A (ja) * | 2013-06-28 | 2016-08-08 | ベイジーン リミテッド | 複数種類のキナーゼの阻害剤としての縮合三環式アミド系化合物 |
| JP2016523269A (ja) * | 2013-06-28 | 2016-08-08 | ベイジーン リミテッド | Ｒａｆキナ−ゼおよび／またはＲａｆキナ−ゼの二量体阻害剤としての縮合三環式ウレア系化合物 |
| JP2019502696A (ja) * | 2015-12-16 | 2019-01-31 | アウトイフオンイ トヘラペウトイクス リミテッド | Ｋｖ３チャネルのヒダントインモジュレーター |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4762917B2 (ja) * | 2004-01-08 | 2011-08-31 | メディヴィル・アクチボラグ | 非ヌクレオシド逆転写酵素インヒビター |
| ATE552245T1 (de) | 2006-05-15 | 2012-04-15 | Merck Sharp & Dohme | Antidiabetische bicyclische verbindungen |
| CA2703217A1 (en) * | 2007-10-29 | 2009-05-07 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
| TWI909513B (zh) | 2019-01-25 | 2025-12-21 | 英屬開曼群島商百濟神州有限公司 | 作為ｂ-ｒａｆ激酶二聚體抑制劑之化合物及其製備方法 |
| CN110551063A (zh) * | 2019-10-17 | 2019-12-10 | 山东邹平大展新材料有限公司 | 一种合成5-(n-boc-哌嗪-1-基)吡啶-2-胺的方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999051613A1 (en) * | 1998-04-03 | 1999-10-14 | Medivir Ab | Prodrugs of phosphorous-containing pharmaceuticals |
| SE0100733D0 (sv) * | 2001-03-05 | 2001-03-05 | Medivir Ab | Non-nucleoside reverse transcriptase inhibitors |
| SE0102867D0 (sv) * | 2001-08-28 | 2001-08-28 | Medivir Ab | Non-nucleoside reverse transcriptase inhibitors |
| JP4762917B2 (ja) * | 2004-01-08 | 2011-08-31 | メディヴィル・アクチボラグ | 非ヌクレオシド逆転写酵素インヒビター |
-
2003
- 2003-09-05 EP EP03793809A patent/EP1534276B1/en not_active Expired - Lifetime
- 2003-09-05 AU AU2003260492A patent/AU2003260492B2/en not_active Ceased
- 2003-09-05 CA CA002501924A patent/CA2501924A1/en not_active Abandoned
- 2003-09-05 CN CNA038249332A patent/CN1694700A/zh active Pending
- 2003-09-05 JP JP2004533489A patent/JP2005538155A/ja not_active Withdrawn
- 2003-09-05 WO PCT/EP2003/009872 patent/WO2004021969A2/en not_active Ceased
- 2003-09-05 AT AT03793809T patent/ATE413174T1/de not_active IP Right Cessation
- 2003-09-05 DE DE60324568T patent/DE60324568D1/de not_active Expired - Fee Related
- 2003-09-05 KR KR1020057003854A patent/KR20050033663A/ko not_active Ceased
- 2003-09-05 MX MXPA05002545A patent/MXPA05002545A/es not_active Application Discontinuation
- 2003-09-05 US US10/526,598 patent/US7517992B2/en not_active Expired - Fee Related
-
2005
- 2005-03-02 ZA ZA200501805A patent/ZA200501805B/en unknown
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016523270A (ja) * | 2013-06-28 | 2016-08-08 | ベイジーン リミテッド | 複数種類のキナーゼの阻害剤としての縮合三環式アミド系化合物 |
| JP2016523269A (ja) * | 2013-06-28 | 2016-08-08 | ベイジーン リミテッド | Ｒａｆキナ−ゼおよび／またはＲａｆキナ−ゼの二量体阻害剤としての縮合三環式ウレア系化合物 |
| JP2019502696A (ja) * | 2015-12-16 | 2019-01-31 | アウトイフオンイ トヘラペウトイクス リミテッド | Ｋｖ３チャネルのヒダントインモジュレーター |
| JP7036725B2 (ja) | 2015-12-16 | 2022-03-15 | アウトイフオンイ トヘラペウトイクス リミテッド | Ｋｖ３チャネルのヒダントインモジュレーター |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1534276B1 (en) | 2008-11-05 |
| AU2003260492A1 (en) | 2004-03-29 |
| ATE413174T1 (de) | 2008-11-15 |
| EP1534276A2 (en) | 2005-06-01 |
| WO2004021969A3 (en) | 2004-08-05 |
| AU2003260492B2 (en) | 2007-03-01 |
| WO2004021969A2 (en) | 2004-03-18 |
| MXPA05002545A (es) | 2005-09-30 |
| KR20050033663A (ko) | 2005-04-12 |
| CA2501924A1 (en) | 2004-03-18 |
| DE60324568D1 (en) | 2008-12-18 |
| US7517992B2 (en) | 2009-04-14 |
| ZA200501805B (en) | 2005-09-08 |
| CN1694700A (zh) | 2005-11-09 |
| US20060167055A1 (en) | 2006-07-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20060531 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20060531 |
|
| A761 | Written withdrawal of application |
Free format text: JAPANESE INTERMEDIATE CODE: A761 Effective date: 20081030 |