JP2005537329A5 - - Google Patents
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- Publication number
- JP2005537329A5 JP2005537329A5 JP2004534522A JP2004534522A JP2005537329A5 JP 2005537329 A5 JP2005537329 A5 JP 2005537329A5 JP 2004534522 A JP2004534522 A JP 2004534522A JP 2004534522 A JP2004534522 A JP 2004534522A JP 2005537329 A5 JP2005537329 A5 JP 2005537329A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- pharmaceutical composition
- group
- cooh
- substance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 239000000126 substance Substances 0.000 claims 4
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 101001059454 Homo sapiens Serine/threonine-protein kinase MARK2 Proteins 0.000 claims 1
- 102100028904 Serine/threonine-protein kinase MARK2 Human genes 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 125000005024 alkenyl aryl group Chemical group 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000003302 alkenyloxy group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000002877 alkyl aryl group Chemical group 0.000 claims 1
- 125000005248 alkyl aryloxy group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 230000006907 apoptotic process Effects 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 125000002102 aryl alkyloxo group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000004104 aryloxy group Chemical group 0.000 claims 1
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 1
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40723902P | 2002-09-03 | 2002-09-03 | |
| PCT/US2003/027607 WO2004022569A1 (en) | 2002-09-03 | 2003-09-03 | Akt inhibitors, pharmaceutical compositions, and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005537329A JP2005537329A (ja) | 2005-12-08 |
| JP2005537329A5 true JP2005537329A5 (https=) | 2006-10-12 |
| JP4641796B2 JP4641796B2 (ja) | 2011-03-02 |
Family
ID=31978442
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004534522A Expired - Fee Related JP4641796B2 (ja) | 2002-09-03 | 2003-09-03 | Ａｋｔ阻害剤、医薬組成物、及びその用途 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7378403B2 (https=) |
| EP (1) | EP1537129B1 (https=) |
| JP (1) | JP4641796B2 (https=) |
| AU (1) | AU2003270087B2 (https=) |
| CA (1) | CA2497572C (https=) |
| WO (1) | WO2004022569A1 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002011676A2 (en) | 2000-08-04 | 2002-02-14 | Dmi Biosciences, Inc. | Method of using diketopiperazines and composition containing them |
| NZ539735A (en) * | 2002-10-02 | 2009-07-31 | Dmi Biosciences Inc | Diagnosis and monitoring of diseases using markers, such as diketopiperazines |
| EP1622633B1 (en) | 2003-05-15 | 2016-02-24 | Ampio Pharmaceuticals, Inc. | Treatment of t-cell mediated diseases |
| WO2008070823A2 (en) * | 2006-12-07 | 2008-06-12 | University Of South Florida | Substrate-mimetic akt inhibitor |
| US20100048524A1 (en) | 2008-03-14 | 2010-02-25 | Angela Brodie | Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens;Synthesis In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity |
| EP2300011A4 (en) | 2008-05-27 | 2012-06-20 | Dmi Life Sciences Inc | THERAPEUTIC PROCESSES AND COMPOUNDS |
| WO2010091306A1 (en) | 2009-02-05 | 2010-08-12 | Tokai Pharmaceuticals | Novel prodrugs of steroidal cyp17 inhibitors/antiandrogens |
| CA2810844C (en) | 2010-09-07 | 2017-03-21 | Dmi Acquisition Corp. | Diketopiperazine compositions for the treatment of metabolic syndrome and related conditions |
| EP3721884A1 (en) | 2011-10-10 | 2020-10-14 | Ampio Pharmaceuticals, Inc. | Treatment of degenerative joint disease with da-dkp (= aspartyl-alanyl diketopiperazine) |
| SG10201608087WA (en) | 2011-10-10 | 2016-11-29 | Ampio Pharmaceuticals Inc | Implantable medical devices with increased immune tolerance, and methods for making and implanting |
| CN103841974A (zh) | 2011-10-28 | 2014-06-04 | 安皮奥制药股份有限公司 | 鼻炎的治疗 |
| KR20150127720A (ko) | 2013-03-14 | 2015-11-17 | 유니버시티 오브 매릴랜드, 발티모어 | 안드로겐 수용체 하향 조절제 및 그의 용도 |
| CA2906864A1 (en) | 2013-03-15 | 2014-09-18 | Ampio Pharmaceuticals, Inc. | Compositions for the mobilization, homing, expansion and differentiation of stem cells and methods of using the same |
| CA2920317A1 (en) | 2013-08-12 | 2015-02-19 | Tokai Pharmaceuticals, Inc. | Biomarkers for treatment of neoplastic disorders using androgen-targeted therapies |
| CA3206628A1 (en) | 2013-09-12 | 2015-03-19 | Dana-Farber Cancer Institute, Inc. | Methods for evaluating and treating waldenstrom's macroglobulinemia |
| CA2958080A1 (en) | 2014-08-18 | 2016-02-25 | Ampio Pharmaceuticals, Inc. | Treatment of joint conditions |
| US11389512B2 (en) | 2015-06-22 | 2022-07-19 | Ampio Pharmaceuticals, Inc. | Use of low molecular weight fractions of human serum albumin in treating diseases |
| CN114981298B (zh) | 2019-12-12 | 2024-08-20 | 听治疗有限责任公司 | 用于预防和治疗听力损失的组合物和方法 |
| CN111704546A (zh) * | 2020-06-30 | 2020-09-25 | 海南师范大学 | 一种含氧环己烷衍生物及其制备方法与应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4585762A (en) * | 1982-07-30 | 1986-04-29 | Fujisawa Pharmaceutical Co., Ltd. | Phospholipid derivatives, processes for use thereof and pharmaceutical composition of the same |
| JPS59187786A (ja) * | 1983-04-11 | 1984-10-24 | Meito Sangyo Kk | 酵素法リン脂質二級アルコ−ル誘導体の製法 |
| DE3476770D1 (en) * | 1983-04-11 | 1989-03-23 | Meito Sangyo Kk | Production of primary or secondary alcohol derivatives of phospholipids by the enzymatic technique |
| US5227508A (en) * | 1992-01-24 | 1993-07-13 | Mayo Foundation For Medical Education And Research | 3-deoxy-3-substituted analogs of phosphatidylinositol |
| AU4427199A (en) * | 1998-06-26 | 2000-01-17 | Georgetown University | Inhibitors of phosphatidyl (myo)-inositol cycle |
-
2003
- 2003-09-03 EP EP03751981.6A patent/EP1537129B1/en not_active Expired - Lifetime
- 2003-09-03 WO PCT/US2003/027607 patent/WO2004022569A1/en not_active Ceased
- 2003-09-03 CA CA2497572A patent/CA2497572C/en not_active Expired - Fee Related
- 2003-09-03 JP JP2004534522A patent/JP4641796B2/ja not_active Expired - Fee Related
- 2003-09-03 AU AU2003270087A patent/AU2003270087B2/en not_active Ceased
- 2003-09-03 US US10/526,851 patent/US7378403B2/en not_active Expired - Fee Related
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