CA2497572C - Akt inhibitors, pharmaceutical compositions, and uses thereof - Google Patents
Akt inhibitors, pharmaceutical compositions, and uses thereof Download PDFInfo
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- CA2497572C CA2497572C CA2497572A CA2497572A CA2497572C CA 2497572 C CA2497572 C CA 2497572C CA 2497572 A CA2497572 A CA 2497572A CA 2497572 A CA2497572 A CA 2497572A CA 2497572 C CA2497572 C CA 2497572C
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- compound
- pharmaceutically acceptable
- acceptable salt
- disease
- akt
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Classifications
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- C07C43/02—Ethers
- C07C43/18—Ethers having an ether-oxygen atom bound to a carbon atom of a ring other than a six-membered aromatic ring
- C07C43/196—Ethers having an ether-oxygen atom bound to a carbon atom of a ring other than a six-membered aromatic ring containing hydroxy or O-metal groups
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- A61P11/08—Bronchodilators
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/117—Esters of phosphoric acids with cycloaliphatic alcohols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
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- Molecular Biology (AREA)
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- Biochemistry (AREA)
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- Orthopedic Medicine & Surgery (AREA)
- Tropical Medicine & Parasitology (AREA)
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- Heart & Thoracic Surgery (AREA)
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- Immunology (AREA)
- Pain & Pain Management (AREA)
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- Dermatology (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US40723902P | 2002-09-03 | 2002-09-03 | |
| US60/407,239 | 2002-09-03 | ||
| PCT/US2003/027607 WO2004022569A1 (en) | 2002-09-03 | 2003-09-03 | Akt inhibitors, pharmaceutical compositions, and uses thereof |
Publications (2)
| Publication Number | Publication Date |
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| CA2497572A1 CA2497572A1 (en) | 2004-03-18 |
| CA2497572C true CA2497572C (en) | 2013-05-14 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2497572A Expired - Fee Related CA2497572C (en) | 2002-09-03 | 2003-09-03 | Akt inhibitors, pharmaceutical compositions, and uses thereof |
Country Status (6)
| Country | Link |
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| US (1) | US7378403B2 (https=) |
| EP (1) | EP1537129B1 (https=) |
| JP (1) | JP4641796B2 (https=) |
| AU (1) | AU2003270087B2 (https=) |
| CA (1) | CA2497572C (https=) |
| WO (1) | WO2004022569A1 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100553636C (zh) | 2000-08-04 | 2009-10-28 | Dmi生物科学公司 | 二酮基哌嗪和包含它们的组合物的使用方法 |
| WO2004030522A2 (en) * | 2002-10-02 | 2004-04-15 | Dmi Biosciences, Inc. | Diagnosis and monitoring of diseases |
| EP2517718B1 (en) | 2003-05-15 | 2016-03-02 | Ampio Pharmaceuticals, Inc. | Treatment of T-cell mediated diseases |
| WO2008070823A2 (en) * | 2006-12-07 | 2008-06-12 | University Of South Florida | Substrate-mimetic akt inhibitor |
| US20100048913A1 (en) | 2008-03-14 | 2010-02-25 | Angela Brodie | Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens;Synthesis In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity |
| JP5856843B2 (ja) | 2008-05-27 | 2016-02-10 | アンピオ ファーマシューティカルズ，インコーポレイテッド | ジケトピペラジンを用いた医薬組成物 |
| CN102686600A (zh) | 2009-02-05 | 2012-09-19 | 托凯药业股份有限公司 | 甾体cyp17抑制剂/抗雄激素物质的新型药物前体 |
| EP2613786A4 (en) | 2010-09-07 | 2013-10-23 | Dmi Acquisition Corp | TREATMENT OF DISEASES |
| MY172699A (en) | 2011-10-10 | 2019-12-10 | Ampio Pharmaceuticals Inc | Implantable medical devices with increased immune tolerance, and methods for making and implanting |
| EA028343B1 (ru) | 2011-10-10 | 2017-11-30 | Ампио Фармасьютикалз, Инк. | Лечение дегенеративного заболевания сустава |
| EP2771007B1 (en) | 2011-10-28 | 2018-04-04 | Ampio Pharmaceuticals, Inc. | Treatment of rhinitis |
| RU2015137617A (ru) | 2013-03-14 | 2017-04-18 | Юниверсити Оф Мэриленд, Балтимор Офис Оф Текнолоджи Трансфер | Агенты, подавляющие андрогенные рецепторы, и их применение |
| BR112015020469A2 (pt) | 2013-03-15 | 2020-01-28 | Ampio Pharmaceuticals Inc | Usos de da-dkp, composição e método para fornecimento de células-tronco a umindivíduo |
| CN105636594A (zh) | 2013-08-12 | 2016-06-01 | 托凯药业股份有限公司 | 使用雄激素靶向疗法用于治疗肿瘤性疾病的生物标记物 |
| AU2014318614B2 (en) | 2013-09-12 | 2021-01-07 | Dana-Farber Cancer Institute Inc. | Methods for evaluating and treating Waldenstrom's macroglobulinemia |
| RU2736513C2 (ru) | 2014-08-18 | 2020-11-17 | Ампио Фармасьютикалз, Инк. | Лечение патологических состояний суставов |
| EP3310375A4 (en) | 2015-06-22 | 2019-02-20 | Ampio Pharmaceuticals, Inc. | USE OF LOW-MOLECULAR FRACTIONS OF HUMAN SERUMALBUMINE IN THE TREATMENT OF ILLNESSES |
| CN118767143A (zh) | 2019-12-12 | 2024-10-15 | 听治疗有限责任公司 | 用于预防和治疗听力损失的组合物和方法 |
| CN111704546A (zh) * | 2020-06-30 | 2020-09-25 | 海南师范大学 | 一种含氧环己烷衍生物及其制备方法与应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US4585762A (en) * | 1982-07-30 | 1986-04-29 | Fujisawa Pharmaceutical Co., Ltd. | Phospholipid derivatives, processes for use thereof and pharmaceutical composition of the same |
| JPS59187786A (ja) * | 1983-04-11 | 1984-10-24 | Meito Sangyo Kk | 酵素法リン脂質二級アルコ−ル誘導体の製法 |
| DE3476770D1 (en) * | 1983-04-11 | 1989-03-23 | Meito Sangyo Kk | Production of primary or secondary alcohol derivatives of phospholipids by the enzymatic technique |
| US5227508A (en) * | 1992-01-24 | 1993-07-13 | Mayo Foundation For Medical Education And Research | 3-deoxy-3-substituted analogs of phosphatidylinositol |
| AU4427199A (en) * | 1998-06-26 | 2000-01-17 | Georgetown University | Inhibitors of phosphatidyl (myo)-inositol cycle |
-
2003
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- 2003-09-03 US US10/526,851 patent/US7378403B2/en not_active Expired - Fee Related
- 2003-09-03 WO PCT/US2003/027607 patent/WO2004022569A1/en not_active Ceased
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- 2003-09-03 EP EP03751981.6A patent/EP1537129B1/en not_active Expired - Lifetime
- 2003-09-03 JP JP2004534522A patent/JP4641796B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005537329A (ja) | 2005-12-08 |
| WO2004022569A1 (en) | 2004-03-18 |
| EP1537129B1 (en) | 2013-11-06 |
| WO2004022569A9 (en) | 2004-06-10 |
| AU2003270087A1 (en) | 2004-03-29 |
| EP1537129A1 (en) | 2005-06-08 |
| US20050272708A1 (en) | 2005-12-08 |
| CA2497572A1 (en) | 2004-03-18 |
| JP4641796B2 (ja) | 2011-03-02 |
| US7378403B2 (en) | 2008-05-27 |
| AU2003270087B2 (en) | 2009-04-23 |
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