JP2005536448A5 - - Google Patents
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- JP2005536448A5 JP2005536448A5 JP2003545613A JP2003545613A JP2005536448A5 JP 2005536448 A5 JP2005536448 A5 JP 2005536448A5 JP 2003545613 A JP2003545613 A JP 2003545613A JP 2003545613 A JP2003545613 A JP 2003545613A JP 2005536448 A5 JP2005536448 A5 JP 2005536448A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- optionally substituted
- oxide
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 tetranylyl Chemical group 0.000 claims 486
- 125000001424 substituent group Chemical group 0.000 claims 171
- 125000000753 cycloalkyl group Chemical group 0.000 claims 79
- 229910052739 hydrogen Inorganic materials 0.000 claims 70
- 125000000217 alkyl group Chemical group 0.000 claims 57
- 229910052717 sulfur Inorganic materials 0.000 claims 41
- 150000001875 compounds Chemical class 0.000 claims 39
- 125000004568 thiomorpholinyl group Chemical group 0.000 claims 37
- 229910052801 chlorine Inorganic materials 0.000 claims 35
- 229910052731 fluorine Inorganic materials 0.000 claims 35
- 229910052736 halogen Inorganic materials 0.000 claims 35
- 150000002367 halogens Chemical class 0.000 claims 35
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 34
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 33
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 33
- 125000004600 benzothiopyranyl group Chemical group S1C(C=CC2=C1C=CC=C2)* 0.000 claims 32
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 32
- 229910052799 carbon Inorganic materials 0.000 claims 29
- 125000004857 imidazopyridinyl group Chemical group N1C(=NC2=C1C=CC=N2)* 0.000 claims 26
- 125000005044 dihydroquinolinyl group Chemical group N1(CC=CC2=CC=CC=C12)* 0.000 claims 25
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 24
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 22
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims 22
- 125000002883 imidazolyl group Chemical group 0.000 claims 22
- 125000002757 morpholinyl group Chemical group 0.000 claims 22
- 125000004193 piperazinyl group Chemical group 0.000 claims 22
- 125000003386 piperidinyl group Chemical group 0.000 claims 22
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 22
- 125000001072 heteroaryl group Chemical group 0.000 claims 21
- 125000003226 pyrazolyl group Chemical group 0.000 claims 21
- 125000001422 pyrrolinyl group Chemical group 0.000 claims 21
- 239000001257 hydrogen Substances 0.000 claims 20
- RCCPEORTSYDPMB-UHFFFAOYSA-N hydroxy benzenecarboximidothioate Chemical compound OSC(=N)C1=CC=CC=C1 RCCPEORTSYDPMB-UHFFFAOYSA-N 0.000 claims 20
- 125000005956 isoquinolyl group Chemical group 0.000 claims 20
- 125000001544 thienyl group Chemical group 0.000 claims 20
- 125000000168 pyrrolyl group Chemical group 0.000 claims 19
- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 claims 19
- 125000003831 tetrazolyl group Chemical group 0.000 claims 19
- 125000004429 atom Chemical group 0.000 claims 17
- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims 17
- 125000003387 indolinyl group Chemical group N1(CCC2=CC=CC=C12)* 0.000 claims 17
- 125000002971 oxazolyl group Chemical group 0.000 claims 17
- 125000004076 pyridyl group Chemical group 0.000 claims 17
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 claims 17
- 125000000335 thiazolyl group Chemical group 0.000 claims 17
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 16
- 125000003118 aryl group Chemical group 0.000 claims 16
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 16
- 125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 claims 16
- 125000001041 indolyl group Chemical group 0.000 claims 16
- 125000000904 isoindolyl group Chemical group C=1(NC=C2C=CC=CC12)* 0.000 claims 16
- 125000000842 isoxazolyl group Chemical group 0.000 claims 16
- 125000001715 oxadiazolyl group Chemical group 0.000 claims 16
- 125000004592 phthalazinyl group Chemical group C1(=NN=CC2=CC=CC=C12)* 0.000 claims 16
- 125000003373 pyrazinyl group Chemical group 0.000 claims 16
- 125000002098 pyridazinyl group Chemical group 0.000 claims 16
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 16
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 16
- 125000001113 thiadiazolyl group Chemical group 0.000 claims 16
- 125000001425 triazolyl group Chemical group 0.000 claims 16
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 claims 15
- 125000005990 isobenzothienyl group Chemical group 0.000 claims 15
- 125000004593 naphthyridinyl group Chemical group N1=C(C=CC2=CC=CN=C12)* 0.000 claims 15
- 125000002047 benzodioxolyl group Chemical group O1OC(C2=C1C=CC=C2)* 0.000 claims 14
- 125000004619 benzopyranyl group Chemical group O1C(C=CC2=C1C=CC=C2)* 0.000 claims 14
- 125000004622 benzoxazinyl group Chemical group O1NC(=CC2=C1C=CC=C2)* 0.000 claims 14
- 125000000609 carbazolyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3NC12)* 0.000 claims 14
- 125000003016 chromanyl group Chemical group O1C(CCC2=CC=CC=C12)* 0.000 claims 14
- 125000000259 cinnolinyl group Chemical group N1=NC(=CC2=CC=CC=C12)* 0.000 claims 14
- 125000000332 coumarinyl group Chemical group O1C(=O)C(=CC2=CC=CC=C12)* 0.000 claims 14
- 125000004594 isoindolinyl group Chemical group C1(NCC2=CC=CC=C12)* 0.000 claims 14
- 125000001786 isothiazolyl group Chemical group 0.000 claims 14
- 125000001484 phenothiazinyl group Chemical group C1(=CC=CC=2SC3=CC=CC=C3NC12)* 0.000 claims 14
- 125000001644 phenoxazinyl group Chemical group C1(=CC=CC=2OC3=CC=CC=C3NC12)* 0.000 claims 14
- 125000001042 pteridinyl group Chemical group N1=C(N=CC2=NC=CN=C12)* 0.000 claims 14
- 125000000561 purinyl group Chemical group N1=C(N=C2N=CNC2=C1)* 0.000 claims 14
- 125000003039 tetrahydroisoquinolinyl group Chemical group C1(NCCC2=CC=CC=C12)* 0.000 claims 14
- 125000005958 tetrahydrothienyl group Chemical group 0.000 claims 14
- 125000004306 triazinyl group Chemical group 0.000 claims 14
- 125000004933 β-carbolinyl group Chemical group C1(=NC=CC=2C3=CC=CC=C3NC12)* 0.000 claims 14
- 125000004617 chromonyl group Chemical group O1C(=CC(C2=CC=CC=C12)=O)* 0.000 claims 13
- 125000005992 dihydrobenzisothiazinyl group Chemical group 0.000 claims 13
- 125000005045 dihydroisoquinolinyl group Chemical group C1(NC=CC2=CC=CC=C12)* 0.000 claims 13
- 125000003151 isocoumarinyl group Chemical group C1(=O)OC(=CC2=CC=CC=C12)* 0.000 claims 13
- 229910052757 nitrogen Inorganic materials 0.000 claims 13
- 150000003839 salts Chemical class 0.000 claims 13
- 125000000147 tetrahydroquinolinyl group Chemical group N1(CCCC2=CC=CC=C12)* 0.000 claims 13
- 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 12
- 125000005046 dihydronaphthyl group Chemical group 0.000 claims 12
- 125000000623 heterocyclic group Chemical group 0.000 claims 12
- 125000004620 quinolinyl-N-oxide group Chemical group 0.000 claims 12
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 12
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 11
- 125000002541 furyl group Chemical group 0.000 claims 11
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 claims 10
- YBYIRNPNPLQARY-UHFFFAOYSA-N 1H-indene Natural products C1=CC=C2CC=CC2=C1 YBYIRNPNPLQARY-UHFFFAOYSA-N 0.000 claims 10
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 claims 10
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 10
- 125000003454 indenyl group Chemical group C1(C=CC2=CC=CC=C12)* 0.000 claims 10
- 125000003384 isochromanyl group Chemical group C1(OCCC2=CC=CC=C12)* 0.000 claims 10
- 125000005993 dihydrobenzisoxazinyl group Chemical group 0.000 claims 9
- 230000014509 gene expression Effects 0.000 claims 9
- 125000005995 isobenzotetrahydrothienyl group Chemical group 0.000 claims 9
- 125000005329 tetralinyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 claims 9
- 125000001624 naphthyl group Chemical group 0.000 claims 8
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 8
- 125000003342 alkenyl group Chemical group 0.000 claims 7
- 125000004852 dihydrofuranyl group Chemical group O1C(CC=C1)* 0.000 claims 7
- 125000005043 dihydropyranyl group Chemical group O1C(CCC=C1)* 0.000 claims 7
- 125000005051 dihydropyrazinyl group Chemical group N1(CC=NC=C1)* 0.000 claims 7
- 125000005052 dihydropyrazolyl group Chemical group N1(NCC=C1)* 0.000 claims 7
- 125000004655 dihydropyridinyl group Chemical group N1(CC=CC=C1)* 0.000 claims 7
- 125000005053 dihydropyrimidinyl group Chemical group N1(CN=CC=C1)* 0.000 claims 7
- 125000005054 dihydropyrrolyl group Chemical group [H]C1=C([H])C([H])([H])C([H])([H])N1* 0.000 claims 7
- 150000002148 esters Chemical class 0.000 claims 7
- 229910052760 oxygen Inorganic materials 0.000 claims 7
- XTKDAFGWCDAMPY-UHFFFAOYSA-N azaperone Chemical compound C1=CC(F)=CC=C1C(=O)CCCN1CCN(C=2N=CC=CC=2)CC1 XTKDAFGWCDAMPY-UHFFFAOYSA-N 0.000 claims 6
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 6
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 6
- 125000006710 (C2-C12) alkenyl group Chemical group 0.000 claims 5
- 125000006711 (C2-C12) alkynyl group Chemical group 0.000 claims 5
- 125000000304 alkynyl group Chemical group 0.000 claims 5
- 208000024827 Alzheimer disease Diseases 0.000 claims 4
- 206010012289 Dementia Diseases 0.000 claims 4
- 125000006574 non-aromatic ring group Chemical group 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 150000001204 N-oxides Chemical class 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 3
- 229910052794 bromium Inorganic materials 0.000 claims 3
- 150000001721 carbon Chemical group 0.000 claims 3
- 208000010877 cognitive disease Diseases 0.000 claims 3
- 125000004981 cycloalkylmethyl group Chemical group 0.000 claims 3
- 125000003406 indolizinyl group Chemical group C=1(C=CN2C=CC=CC12)* 0.000 claims 3
- 229910052740 iodine Inorganic materials 0.000 claims 3
- 208000027061 mild cognitive impairment Diseases 0.000 claims 3
- 239000001301 oxygen Substances 0.000 claims 3
- 125000006413 ring segment Chemical group 0.000 claims 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 2
- 125000006288 3,5-difluorobenzyl group Chemical group [H]C1=C(F)C([H])=C(C([H])=C1F)C([H])([H])* 0.000 claims 2
- 125000003143 4-hydroxybenzyl group Chemical group [H]C([*])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H] 0.000 claims 2
- 125000001318 4-trifluoromethylbenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])*)C(F)(F)F 0.000 claims 2
- 125000005466 alkylenyl group Chemical group 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 125000001400 nonyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- MHCVCKDNQYMGEX-UHFFFAOYSA-N 1,1'-biphenyl;phenoxybenzene Chemical group C1=CC=CC=C1C1=CC=CC=C1.C=1C=CC=CC=1OC1=CC=CC=C1 MHCVCKDNQYMGEX-UHFFFAOYSA-N 0.000 claims 1
- NEGMMKYAVYNLCG-UHFFFAOYSA-N 5-ethyl-1-methyl-5-phenylimidazolidine-2,4-dione Chemical compound C=1C=CC=CC=1C1(CC)N(C)C(=O)NC1=O NEGMMKYAVYNLCG-UHFFFAOYSA-N 0.000 claims 1
- 208000005145 Cerebral amyloid angiopathy Diseases 0.000 claims 1
- 206010008111 Cerebral haemorrhage Diseases 0.000 claims 1
- 208000011990 Corticobasal Degeneration Diseases 0.000 claims 1
- 102100036238 Dihydropyrimidinase Human genes 0.000 claims 1
- 201000010374 Down Syndrome Diseases 0.000 claims 1
- 208000032843 Hemorrhage Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 206010002022 amyloidosis Diseases 0.000 claims 1
- 125000002785 azepinyl group Chemical group 0.000 claims 1
- 125000002393 azetidinyl group Chemical group 0.000 claims 1
- 125000002619 bicyclic group Chemical group 0.000 claims 1
- 125000002837 carbocyclic group Chemical group 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 230000003412 degenerative effect Effects 0.000 claims 1
- 108091022884 dihydropyrimidinase Proteins 0.000 claims 1
- 125000005994 isobenzotetrahydrofuranyl group Chemical group 0.000 claims 1
- 125000005487 naphthalate group Chemical group 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 201000002212 progressive supranuclear palsy Diseases 0.000 claims 1
- 230000000306 recurrent effect Effects 0.000 claims 1
- 230000002739 subcortical effect Effects 0.000 claims 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
- 0 *CC(C(C(*)N(*)N)O)O Chemical compound *CC(C(C(*)N(*)N)O)O 0.000 description 4
- FTUQYVKZURNABV-UOCPRXARSA-N CCCN(CCC)C(c1cc(C)cc(C(N[C@@H](Cc2cc(F)cc(F)c2)C([C@@H](COC2CCCCC2)O)O)=O)c1)=O Chemical compound CCCN(CCC)C(c1cc(C)cc(C(N[C@@H](Cc2cc(F)cc(F)c2)C([C@@H](COC2CCCCC2)O)O)=O)c1)=O FTUQYVKZURNABV-UOCPRXARSA-N 0.000 description 1
- RZRMXSHIYDXONN-CONSDPRKSA-N CCCN(CCC)C(c1cc(C)cc(C(N[C@@H](Cc2cc(F)cc(F)c2)[C@H](CCOCc2ccccc2)O)=O)c1)=O Chemical compound CCCN(CCC)C(c1cc(C)cc(C(N[C@@H](Cc2cc(F)cc(F)c2)[C@H](CCOCc2ccccc2)O)=O)c1)=O RZRMXSHIYDXONN-CONSDPRKSA-N 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33308101P | 2001-11-19 | 2001-11-19 | |
| US33400001P | 2001-11-28 | 2001-11-28 | |
| US36275202P | 2002-03-08 | 2002-03-08 | |
| PCT/US2002/036999 WO2003043975A1 (en) | 2001-11-19 | 2002-11-19 | Amine 1,2- and 1,3-diol compounds and their use for treatment of alzheimer's disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005536448A JP2005536448A (ja) | 2005-12-02 |
| JP2005536448A5 true JP2005536448A5 (https=) | 2006-01-19 |
Family
ID=27406892
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003545613A Pending JP2005536448A (ja) | 2001-11-19 | 2002-11-19 | アミン１，２−及び１，３−ジオール化合物、及びアルツハイマー病を治療するためのその使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7388118B2 (https=) |
| EP (1) | EP1453792B1 (https=) |
| JP (1) | JP2005536448A (https=) |
| AT (1) | ATE359995T1 (https=) |
| AU (1) | AU2002362008A1 (https=) |
| BR (1) | BR0214293A (https=) |
| CA (1) | CA2467798A1 (https=) |
| DE (1) | DE60219680T2 (https=) |
| ES (1) | ES2284970T3 (https=) |
| MX (1) | MXPA04004771A (https=) |
| WO (1) | WO2003043975A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007516207A (ja) | 2003-06-30 | 2007-06-21 | メルク エンド カムパニー インコーポレーテッド | アルツハイマー病の治療のためのＮ−アルキルフェニルカルボキサミドβ−セクレターゼ阻害剤 |
| ITPD20040151A1 (it) * | 2004-06-15 | 2004-09-15 | Univ Degli Studi Trieste | Inibitori peptidomimetici di proteasi retrovirali e loro uso come antivirali |
| WO2010107384A1 (en) * | 2009-03-19 | 2010-09-23 | Medivir Ab | Aspartyl protease inhibitors |
| EP3623371A1 (en) | 2014-12-16 | 2020-03-18 | Axovant Sciences GmbH | Geminal substituted quinuclidine amide compounds as agonists of alpha-7 nicotinic acetylcholine receptors |
| CN107847494A (zh) | 2015-06-10 | 2018-03-27 | 阿考温特科学股份有限公司 | 作为α7‑烟碱乙酰胆碱受体激动剂的氨基苯并异噁唑化合物 |
| JP2018523707A (ja) | 2015-08-12 | 2018-08-23 | アクソバント サイエンシズ ゲーエムベーハー | α７−ニコチン性アセチルコリン受容体のアゴニストとしてのジェミナル置換アミノベンゾイソオキサゾール化合物 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4864017A (en) | 1986-09-05 | 1989-09-05 | The Upjohn Company | Novel renin inhibiting peptides having a dihyroxyethylene isostere transition state insert |
| DE60124080T2 (de) * | 2000-03-23 | 2007-03-01 | Elan Pharmaceuticals, Inc., San Francisco | Verbindungen und verfahren zur behandlung der alzheimerschen krankheit |
| JP2004502664A (ja) * | 2000-06-30 | 2004-01-29 | イーラン ファーマスーティカルズ、インコーポレイテッド | アルツハイマー病処置用化合物 |
| US6846813B2 (en) * | 2000-06-30 | 2005-01-25 | Pharmacia & Upjohn Company | Compounds to treat alzheimer's disease |
| PE20020276A1 (es) * | 2000-06-30 | 2002-04-06 | Elan Pharm Inc | COMPUESTOS DE AMINA SUSTITUIDA COMO INHIBIDORES DE ß-SECRETASA PARA EL TRATAMIENTO DE ALZHEIMER |
| US6906104B2 (en) * | 2001-06-13 | 2005-06-14 | Pharmacia & Upjohn Company | Aminediols for the treatment of Alzheimer's disease |
-
2002
- 2002-11-19 AT AT02797133T patent/ATE359995T1/de not_active IP Right Cessation
- 2002-11-19 ES ES02797133T patent/ES2284970T3/es not_active Expired - Lifetime
- 2002-11-19 EP EP02797133A patent/EP1453792B1/en not_active Expired - Lifetime
- 2002-11-19 BR BR0214293-7A patent/BR0214293A/pt not_active IP Right Cessation
- 2002-11-19 JP JP2003545613A patent/JP2005536448A/ja active Pending
- 2002-11-19 US US10/299,739 patent/US7388118B2/en not_active Expired - Fee Related
- 2002-11-19 AU AU2002362008A patent/AU2002362008A1/en not_active Abandoned
- 2002-11-19 DE DE60219680T patent/DE60219680T2/de not_active Expired - Fee Related
- 2002-11-19 CA CA002467798A patent/CA2467798A1/en not_active Abandoned
- 2002-11-19 MX MXPA04004771A patent/MXPA04004771A/es active IP Right Grant
- 2002-11-19 WO PCT/US2002/036999 patent/WO2003043975A1/en not_active Ceased
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