JP2005534287A - 癌の処置および検出において有用な98p4b6との名称の核酸および対応するタンパク質 - Google Patents
癌の処置および検出において有用な98p4b6との名称の核酸および対応するタンパク質 Download PDFInfo
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PCT/US2003/010462 WO2003087306A2 (fr) | 2002-04-05 | 2003-04-04 | Acide nucleique et proteine correspondante 98p4b6 utilises dans le traitement et la detection du cancer |
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JP2019532056A (ja) * | 2016-09-23 | 2019-11-07 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. | 抗steap2抗体、抗体−薬物複合体、およびsteap2とcd3を結合する二重特異性抗原結合分子、ならびにそれらの使用 |
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KR101438983B1 (ko) | 2003-11-06 | 2014-09-05 | 시애틀 지네틱스, 인크. | 리간드에 접합될 수 있는 모노메틸발린 화합물 |
WO2005079490A2 (fr) * | 2004-02-13 | 2005-09-01 | Nuvelo, Inc. | Procedes de therapie et de diagnostic reposant sur le ciblage de cellules qui expriment les polypeptides steap2 |
EP1753463A2 (fr) | 2004-06-01 | 2007-02-21 | Genentech, Inc. | Conjugues de medicaments anticorps et procedes correspondants |
WO2006015165A2 (fr) * | 2004-07-26 | 2006-02-09 | Enzon Pharmaceuticals, Inc. | Gene optimise pour exprimer l'interferon beta |
RU2412947C2 (ru) | 2004-09-23 | 2011-02-27 | Дженентек, Инк. | Антитела, сконструированные на основе цистеинов, и их конъюгаты |
US20100111856A1 (en) | 2004-09-23 | 2010-05-06 | Herman Gill | Zirconium-radiolabeled, cysteine engineered antibody conjugates |
AU2010268690B2 (en) | 2009-07-03 | 2011-11-10 | Avipep Pty Ltd | Immuno-conjugates and methods for producing them |
EP2475391B1 (fr) | 2009-09-09 | 2018-09-12 | Centrose, LLC | Conjugués médicamenteux ciblés à visée extracellulaire |
AU2010336029B2 (en) | 2009-12-23 | 2011-10-13 | Avipep Pty Ltd | Immuno-conjugates and methods for producing them 2 |
WO2011130598A1 (fr) | 2010-04-15 | 2011-10-20 | Spirogen Limited | Pyrrolobenzodiazépines et conjugués de celles-ci |
CN114246952A (zh) | 2010-06-08 | 2022-03-29 | 基因泰克公司 | 半胱氨酸改造的抗体和偶联物 |
CN103313990B (zh) | 2010-11-17 | 2016-07-20 | 基因泰克公司 | 丙氨酰美登醇抗体偶联物 |
CN103619877B (zh) | 2011-04-21 | 2018-01-02 | 加文医学研究所 | 修饰的可变结构域分子及其产生和使用方法b |
MX2013013054A (es) | 2011-05-12 | 2014-02-20 | Genentech Inc | Metodo de monitoreo de lc-ms/ms de reaccion multiple para detectar anticuerpos terapeuticos en muestras de animales utilizando peptidos de firma de estructura. |
DK2750713T3 (en) | 2011-10-14 | 2015-12-21 | Medimmune Ltd | PYRROLOBENZODIAZEPINS AND CONJUGATES THEREOF |
WO2013130093A1 (fr) | 2012-03-02 | 2013-09-06 | Genentech, Inc. | Biomarqueurs pour un traitement à base de composés chimiothérapeutiques anti-tubuline |
US9931414B2 (en) | 2012-10-12 | 2018-04-03 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
US10695433B2 (en) | 2012-10-12 | 2020-06-30 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
US10736903B2 (en) | 2012-10-12 | 2020-08-11 | Medimmune Limited | Pyrrolobenzodiazepine-anti-PSMA antibody conjugates |
RS53818B1 (en) | 2012-10-12 | 2015-06-30 | Spirogen Sàrl | PIROLOBENZODIAZEPINI I NJIHOVI conjugated |
WO2014057119A1 (fr) | 2012-10-12 | 2014-04-17 | Adc Therapeutics Sàrl | Conjugués anticorps - pyrrolobenzodiazépine |
EP2906251B1 (fr) | 2012-10-12 | 2017-09-27 | ADC Therapeutics SA | Conjugués anticorps anti-cd22 - pyrrolobenzodiazépine |
PT2906253T (pt) | 2012-10-12 | 2018-11-05 | Medimmune Ltd | Conjugados de anticorpo anti-psma de pirrolobenzodiazepina |
WO2014096368A1 (fr) | 2012-12-21 | 2014-06-26 | Spirogen Sàrl | Pyrrolobenzodiazépines et conjugués associés |
JP6527466B2 (ja) | 2012-12-21 | 2019-06-05 | メドイミューン・リミテッドMedImmune Limited | 増殖性疾患および自己免疫疾患の治療に使用するための非対称ピロロベンゾジアゼピンニ量体 |
EA027910B1 (ru) | 2013-03-13 | 2017-09-29 | Медимьюн Лимитед | Пирролобензодиазепины и их конъюгаты |
BR112015023333A8 (pt) | 2013-03-13 | 2018-04-17 | Medimmune Ltd | pirrolbenzodiazepinas e conjugados dos mesmos |
JP6340019B2 (ja) | 2013-03-13 | 2018-06-06 | メドイミューン・リミテッドMedImmune Limited | ピロロベンゾジアゼピン及びそのコンジュゲート |
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PT1244705E (pt) * | 1999-12-06 | 2010-05-04 | Agensys Inc | Antigénios transmembranares em serpentina expressos em cancros da próstata humanos e suas utilizações |
WO2001072962A2 (fr) * | 2000-03-24 | 2001-10-04 | Fahri Saatcioglu | Molecules d'acide nucleique specifiques de la prostate ou des testicules, polypeptides, techniques de diagnostic, et traitement therapeutique |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2019532056A (ja) * | 2016-09-23 | 2019-11-07 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. | 抗steap2抗体、抗体−薬物複合体、およびsteap2とcd3を結合する二重特異性抗原結合分子、ならびにそれらの使用 |
JP2022091976A (ja) * | 2016-09-23 | 2022-06-21 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 抗steap2抗体、抗体-薬物複合体、およびsteap2とcd3を結合する二重特異性抗原結合分子、ならびにそれらの使用 |
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WO2003087306A8 (fr) | 2006-10-05 |
NZ535762A (en) | 2009-04-30 |
WO2003087306A2 (fr) | 2003-10-23 |
EP1572916A4 (fr) | 2007-05-30 |
EP1572916A2 (fr) | 2005-09-14 |
CA2481503A1 (fr) | 2003-10-23 |
BR0308953A (pt) | 2006-03-14 |
AU2009230789A1 (en) | 2009-11-19 |
MXPA04009728A (es) | 2005-06-08 |
AU2003223469A1 (en) | 2003-10-27 |
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