JP2005533082A5 - - Google Patents
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- Publication number
- JP2005533082A5 JP2005533082A5 JP2004516732A JP2004516732A JP2005533082A5 JP 2005533082 A5 JP2005533082 A5 JP 2005533082A5 JP 2004516732 A JP2004516732 A JP 2004516732A JP 2004516732 A JP2004516732 A JP 2004516732A JP 2005533082 A5 JP2005533082 A5 JP 2005533082A5
- Authority
- JP
- Japan
- Prior art keywords
- gaba
- halogen
- antagonist
- general formula
- nitrile
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000681 4 aminobutyric acid C receptor blocking agent Substances 0.000 claims 9
- 229910052736 halogen Inorganic materials 0.000 claims 8
- 150000002367 halogens Chemical group 0.000 claims 8
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 150000002431 hydrogen Chemical group 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 150000002825 nitriles Chemical group 0.000 claims 4
- 229940122557 GABA C receptor antagonist Drugs 0.000 claims 3
- 125000002252 acyl group Chemical group 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 2
- 208000001491 myopia Diseases 0.000 claims 2
- 230000004379 myopia Effects 0.000 claims 2
- HIHOEGPXVVKJPP-JTQLQIEISA-N 5-fluoro-2-[[(1s)-1-(5-fluoropyridin-2-yl)ethyl]amino]-6-[(5-methyl-1h-pyrazol-3-yl)amino]pyridine-3-carbonitrile Chemical group N([C@@H](C)C=1N=CC(F)=CC=1)C(C(=CC=1F)C#N)=NC=1NC=1C=C(C)NN=1 HIHOEGPXVVKJPP-JTQLQIEISA-N 0.000 claims 1
- 108060003377 GABA-B receptor Proteins 0.000 claims 1
- 102000017934 GABA-B receptor Human genes 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001629 suppression Effects 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 239000003412 4 aminobutyric acid B receptor blocking agent Substances 0.000 description 3
- JJMDCOVWQOJGCB-UHFFFAOYSA-N 5-aminopentanoic acid Chemical compound [NH3+]CCCCC([O-])=O JJMDCOVWQOJGCB-UHFFFAOYSA-N 0.000 description 2
- GSZQTIFGANBTNF-UHFFFAOYSA-N (3-aminopropyl)phosphonic acid Chemical compound NCCCP(O)(O)=O GSZQTIFGANBTNF-UHFFFAOYSA-N 0.000 description 1
- WBSMZVIMANOCNX-UHFFFAOYSA-N 3-amino-2-(4-chlorophenyl)-2-hydroxy-1-propanesulfonic acid Chemical compound OS(=O)(=O)CC(O)(CN)C1=CC=C(Cl)C=C1 WBSMZVIMANOCNX-UHFFFAOYSA-N 0.000 description 1
- QVUUPQCCYOPHFY-UHFFFAOYSA-N 3-aminopropyl(hexyl)phosphinic acid Chemical compound CCCCCCP(O)(=O)CCCN QVUUPQCCYOPHFY-UHFFFAOYSA-N 0.000 description 1
- QIIVUOWTHWIXFO-UHFFFAOYSA-N cgp-35348 Chemical compound CCOC(OCC)P(O)(=O)CCCN QIIVUOWTHWIXFO-UHFFFAOYSA-N 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02014412 | 2002-06-28 | ||
| PCT/EP2003/006850 WO2004002399A2 (en) | 2002-06-28 | 2003-06-27 | Use of gaba-c receptor antagonists for the treatment of myopia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005533082A JP2005533082A (ja) | 2005-11-04 |
| JP2005533082A5 true JP2005533082A5 (enExample) | 2006-08-31 |
Family
ID=29797147
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004516732A Pending JP2005533082A (ja) | 2002-06-28 | 2003-06-27 | 近視の治療のためのｇａｂａ−ｃレセプターアンタゴニストの使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20060142249A1 (enExample) |
| EP (1) | EP1526858A2 (enExample) |
| JP (1) | JP2005533082A (enExample) |
| AU (1) | AU2003245995A1 (enExample) |
| WO (1) | WO2004002399A2 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201808713YA (en) * | 2016-04-11 | 2018-11-29 | Univ Canberra | Ophthalmic compositions comprising levodopa, an antioxidant and an aqueous carrier |
| KR102747804B1 (ko) * | 2024-03-07 | 2024-12-31 | 주식회사 케이에스비튜젠 | 라세탐 계열 화합물을 유효성분으로 포함하는 눈 기능 장애 예방, 개선 또는 치료용 조성물 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5385939A (en) * | 1993-04-30 | 1995-01-31 | The Trustees Of The University Of Pennsylvania | GABA-ergic modulation of eye growth |
| US5627169A (en) * | 1994-07-20 | 1997-05-06 | The Regents Of The University Of California | Selective antagonists for GABArho receptor |
| WO1998028313A1 (en) * | 1996-12-24 | 1998-07-02 | Novartis Ag | (thio)morpholine-substituted carboxylic and phosphinic acids |
| EP1000071B1 (en) * | 1997-06-23 | 2004-11-17 | Polychip Pharmaceuticals Pty. Ltd. | Gaba-c receptor antagonists for stimulating memory capacity |
| US20060264508A1 (en) * | 2001-10-16 | 2006-11-23 | Stone Richard A | Modulation of ocular growth and myopia by gaba drugs |
-
2003
- 2003-06-27 JP JP2004516732A patent/JP2005533082A/ja active Pending
- 2003-06-27 US US10/516,246 patent/US20060142249A1/en not_active Abandoned
- 2003-06-27 AU AU2003245995A patent/AU2003245995A1/en not_active Abandoned
- 2003-06-27 EP EP03738095A patent/EP1526858A2/en not_active Withdrawn
- 2003-06-27 WO PCT/EP2003/006850 patent/WO2004002399A2/en not_active Ceased
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