JP2005533082A - 近視の治療のためのｇａｂａ−ｃレセプターアンタゴニストの使用 - Google Patents
近視の治療のためのｇａｂａ−ｃレセプターアンタゴニストの使用 Download PDFInfo
- Publication number
- JP2005533082A JP2005533082A JP2004516732A JP2004516732A JP2005533082A JP 2005533082 A JP2005533082 A JP 2005533082A JP 2004516732 A JP2004516732 A JP 2004516732A JP 2004516732 A JP2004516732 A JP 2004516732A JP 2005533082 A JP2005533082 A JP 2005533082A
- Authority
- JP
- Japan
- Prior art keywords
- gaba
- myopia
- antagonist
- halogen
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 208000001491 myopia Diseases 0.000 title claims abstract description 20
- 230000004379 myopia Effects 0.000 title claims abstract description 20
- 229940122557 GABA C receptor antagonist Drugs 0.000 title claims description 10
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- 238000004519 manufacturing process Methods 0.000 claims abstract description 5
- 239000000681 4 aminobutyric acid C receptor blocking agent Substances 0.000 claims description 18
- 229910052736 halogen Inorganic materials 0.000 claims description 13
- 150000002367 halogens Chemical group 0.000 claims description 13
- 150000001875 compounds Chemical class 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 11
- 125000000217 alkyl group Chemical group 0.000 claims description 9
- 125000003342 alkenyl group Chemical group 0.000 claims description 7
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- 125000003545 alkoxy group Chemical group 0.000 claims description 6
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- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 1
- 125000001494 2-propynyl group Chemical group [H]C#CC([H])([H])* 0.000 description 1
- WBSMZVIMANOCNX-UHFFFAOYSA-N 3-amino-2-(4-chlorophenyl)-2-hydroxy-1-propanesulfonic acid Chemical compound OS(=O)(=O)CC(O)(CN)C1=CC=C(Cl)C=C1 WBSMZVIMANOCNX-UHFFFAOYSA-N 0.000 description 1
- QVUUPQCCYOPHFY-UHFFFAOYSA-N 3-aminopropyl(hexyl)phosphinic acid Chemical compound CCCCCCP(O)(=O)CCCN QVUUPQCCYOPHFY-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 241000416162 Astragalus gummifer Species 0.000 description 1
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- MKRNVBXERAPZOP-UHFFFAOYSA-N Starch acetate Chemical compound O1C(CO)C(OC)C(O)C(O)C1OCC1C(OC2C(C(O)C(OC)C(CO)O2)OC(C)=O)C(O)C(O)C(OC2C(OC(C)C(O)C2O)CO)O1 MKRNVBXERAPZOP-UHFFFAOYSA-N 0.000 description 1
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- 230000015572 biosynthetic process Effects 0.000 description 1
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- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 description 1
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- 125000003707 hexyloxy group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])O* 0.000 description 1
- 125000005980 hexynyl group Chemical group 0.000 description 1
- 239000001341 hydroxy propyl starch Substances 0.000 description 1
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- 230000002401 inhibitory effect Effects 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 235000010494 karaya gum Nutrition 0.000 description 1
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- MFUKVPOVVKKLRQ-UHFFFAOYSA-N methyl(1,2,3,6-tetrahydropyridin-1-ium-4-yl)phosphinate Chemical compound CP(O)(=O)C1=CCNCC1 MFUKVPOVVKKLRQ-UHFFFAOYSA-N 0.000 description 1
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- 125000004365 octenyl group Chemical group C(=CCCCCCC)* 0.000 description 1
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- 125000005069 octynyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C#C* 0.000 description 1
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- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 description 1
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- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02014412 | 2002-06-28 | ||
| PCT/EP2003/006850 WO2004002399A2 (en) | 2002-06-28 | 2003-06-27 | Use of gaba-c receptor antagonists for the treatment of myopia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005533082A true JP2005533082A (ja) | 2005-11-04 |
| JP2005533082A5 JP2005533082A5 (enExample) | 2006-08-31 |
Family
ID=29797147
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004516732A Pending JP2005533082A (ja) | 2002-06-28 | 2003-06-27 | 近視の治療のためのｇａｂａ−ｃレセプターアンタゴニストの使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20060142249A1 (enExample) |
| EP (1) | EP1526858A2 (enExample) |
| JP (1) | JP2005533082A (enExample) |
| AU (1) | AU2003245995A1 (enExample) |
| WO (1) | WO2004002399A2 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019511537A (ja) * | 2016-04-11 | 2019-04-25 | ユニバーシティ・オブ・キャンベラＵｎｉｖｅｒｓｉｔｙ ｏｆ Ｃａｎｂｅｒｒａ | レボドパ、抗酸化剤及び水性担体を含む眼科用組成物 |
| WO2025187884A1 (ko) * | 2024-03-07 | 2025-09-12 | 주식회사 케이에스비튜젠 | 눈 기능 장애 예방, 개선 또는 치료용 조성물 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5385939A (en) * | 1993-04-30 | 1995-01-31 | The Trustees Of The University Of Pennsylvania | GABA-ergic modulation of eye growth |
| US5627169A (en) * | 1994-07-20 | 1997-05-06 | The Regents Of The University Of California | Selective antagonists for GABArho receptor |
| WO1998028313A1 (en) * | 1996-12-24 | 1998-07-02 | Novartis Ag | (thio)morpholine-substituted carboxylic and phosphinic acids |
| EP1000071B1 (en) * | 1997-06-23 | 2004-11-17 | Polychip Pharmaceuticals Pty. Ltd. | Gaba-c receptor antagonists for stimulating memory capacity |
| US20060264508A1 (en) * | 2001-10-16 | 2006-11-23 | Stone Richard A | Modulation of ocular growth and myopia by gaba drugs |
-
2003
- 2003-06-27 JP JP2004516732A patent/JP2005533082A/ja active Pending
- 2003-06-27 US US10/516,246 patent/US20060142249A1/en not_active Abandoned
- 2003-06-27 AU AU2003245995A patent/AU2003245995A1/en not_active Abandoned
- 2003-06-27 EP EP03738095A patent/EP1526858A2/en not_active Withdrawn
- 2003-06-27 WO PCT/EP2003/006850 patent/WO2004002399A2/en not_active Ceased
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019511537A (ja) * | 2016-04-11 | 2019-04-25 | ユニバーシティ・オブ・キャンベラＵｎｉｖｅｒｓｉｔｙ ｏｆ Ｃａｎｂｅｒｒａ | レボドパ、抗酸化剤及び水性担体を含む眼科用組成物 |
| JP7095873B2 (ja) | 2016-04-11 | 2022-07-05 | ユニバーシティ・オブ・キャンベラ | レボドパ、抗酸化剤及び水性担体を含む眼科用組成物 |
| JP2022116357A (ja) * | 2016-04-11 | 2022-08-09 | ユニバーシティ・オブ・キャンベラ | レボドパ、抗酸化剤及び水性担体を含む眼科用組成物 |
| US11890266B2 (en) | 2016-04-11 | 2024-02-06 | University Of Canberra | Ophthalmic compositions including levodopa, an antioxidant and an aqueous carrier |
| WO2025187884A1 (ko) * | 2024-03-07 | 2025-09-12 | 주식회사 케이에스비튜젠 | 눈 기능 장애 예방, 개선 또는 치료용 조성물 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003245995A1 (en) | 2004-01-19 |
| AU2003245995A8 (en) | 2004-01-19 |
| WO2004002399A3 (en) | 2004-04-01 |
| US20060142249A1 (en) | 2006-06-29 |
| EP1526858A2 (en) | 2005-05-04 |
| WO2004002399A2 (en) | 2004-01-08 |
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