JP2005533055A - 新規マキシｋチャンネルブロッカー、その使用方法および製造方法 - Google Patents

新規マキシｋチャンネルブロッカー、その使用方法および製造方法 Download PDF

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Publication number
JP2005533055A
JP2005533055A JP2004512635A JP2004512635A JP2005533055A JP 2005533055 A JP2005533055 A JP 2005533055A JP 2004512635 A JP2004512635 A JP 2004512635A JP 2004512635 A JP2004512635 A JP 2004512635A JP 2005533055 A JP2005533055 A JP 2005533055A
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Japan
Prior art keywords
alkyl
compound
formula
pharmaceutically acceptable
prostaglandin
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Application number
JP2004512635A
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English (en)
Japanese (ja)
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JP2005533055A5 (https=
Inventor
ガルシア，マリア・エル
ゲツツ，マイケル・エー
カクゾロウスキー，グレゴリー・ジエイ
マクマナス，オーウエン・ビー
モナハン，リチヤード・エル
ストロール，ウイリアム・アール
トカツチユ，ジヤン・エス
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
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Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of JP2005533055A publication Critical patent/JP2005533055A/ja
Publication of JP2005533055A5 publication Critical patent/JP2005533055A5/ja
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2004512635A 2002-06-17 2003-06-13 新規マキシｋチャンネルブロッカー、その使用方法および製造方法 Withdrawn JP2005533055A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38922202P 2002-06-17 2002-06-17
PCT/US2003/018842 WO2003105724A2 (en) 2002-06-17 2003-06-13 Novel maxi-k channel blockers, methods of use and process for making the same

Publications (2)

Publication Number Publication Date
JP2005533055A true JP2005533055A (ja) 2005-11-04
JP2005533055A5 JP2005533055A5 (https=) 2009-03-26

Family

ID=29736611

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004512635A Withdrawn JP2005533055A (ja) 2002-06-17 2003-06-13 新規マキシｋチャンネルブロッカー、その使用方法および製造方法

Country Status (6)

Country Link
US (1) US7294646B2 (https=)
EP (1) EP1515974A4 (https=)
JP (1) JP2005533055A (https=)
AU (1) AU2003247533B2 (https=)
CA (1) CA2488752A1 (https=)
WO (1) WO2003105724A2 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7053085B2 (en) 2003-03-26 2006-05-30 Merck & Co. Inc. EP4 receptor agonist, compositions and methods thereof
US20090148527A1 (en) * 2007-12-07 2009-06-11 Robinson Michael R Intraocular formulation
PT1905452E (pt) * 2005-07-12 2013-07-16 Kowa Co Agente para a prevenção ou tratamento do glaucoma
WO2009048559A1 (en) * 2007-10-11 2009-04-16 Merck & Co., Inc. Maxi-k channel blockers and methods of use
WO2009048558A1 (en) * 2007-10-11 2009-04-16 Merck & Co., Inc. Maxi-k channel blockers and methods of use
US8299079B2 (en) 2009-05-22 2012-10-30 Kaufman Herbert E Preparations and methods for ameliorating or reducing presbyopia
CN109593074B (zh) * 2017-09-30 2020-07-28 华中科技大学 真菌次生代谢产物中具有抗菌活性化合物的分离制备及用途

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4416890A (en) 1981-07-13 1983-11-22 Merck & Co., Inc. Benzothiazolesulfonamide derivatives for the topical treatment of elevated intraocular pressure
US4386098A (en) 1981-11-03 1983-05-31 Merck & Co., Inc. 6-Hydroxy-2-benzothiazolesulfonamide for the topical treatment of elevated intraocular pressure
US4426388A (en) 1982-04-02 1984-01-17 Merck & Co., Inc. 5-Benzothiazolesulfonamide derivatives for the topical treatment of elevated intraocular pressure
US4599353A (en) 1982-05-03 1986-07-08 The Trustees Of Columbia University In The City Of New York Use of eicosanoids and their derivatives for treatment of ocular hypertension and glaucoma
US4668697A (en) 1983-10-31 1987-05-26 Merck & Co., Inc. Elevated intraocular pressure lowering benzo-[b]-thiophene-2-sulfonamide derivatives, compositions, and method of use therefor
US4863922A (en) 1984-12-12 1989-09-05 Merck & Co., Inc. Substituted aromatic sulfonamides as antiglaucoma agents, compositions and use
US4797413A (en) 1986-05-14 1989-01-10 Merck & Co., Inc. Thieno thiopyran sulfonamide derivatives, pharmaceutical compositions and use
US4883819A (en) 1986-07-31 1989-11-28 The Trustees Of Columbia University In The City Of New York Use of A, B and C prostaglandins and derivatives thereof to treat ocular hypertension and glaucoma
US4824857A (en) 1986-05-16 1989-04-25 Yasumasa Goh Use of prostaglandin D2 -active substances
DE3850676T2 (de) 1987-09-18 1994-11-03 Ueno Seiyaku Oyo Kenkyujo Kk Hypotensive okulare Mittel.
AU3693789A (en) 1988-05-10 1989-11-29 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) New ophthalmic preparation for treating glaucoma
US5153192A (en) 1990-04-09 1992-10-06 Alcon Laboratories, Inc. Thiophene sulfonamides useful as carbonic anhydrase inhibitors
US5378703A (en) 1990-04-09 1995-01-03 Alcon Laboratories, Inc. Sulfonamides useful as carbonic anhydrase inhibitors
US5227396A (en) * 1991-07-19 1993-07-13 The United States Of America As Represented By The Secretary Of Agriculture Indole antiinsectan metabolites
AU7099194A (en) 1993-06-08 1995-01-03 Vide Pharmaceuticals Methods and compositions for lowering intraocular pressure
US5541208A (en) * 1994-01-24 1996-07-30 Merck & Co., Inc. Indole diterpene alkaloid compounds
US5573758A (en) 1995-04-28 1996-11-12 Allergan Method for reducing intraocular pressure in the mammalian eye by administration of potassium channel blockers
US5925342A (en) 1996-11-13 1999-07-20 Allergan Method for reducing intraocular pressure in the mammalian eye by administration of potassium channel blockers
US6548535B2 (en) * 2000-01-18 2003-04-15 Merck & Co., Inc. Method for treating ocular hypertension
WO2001070686A1 (en) * 2000-03-17 2001-09-27 Alcon, Inc. 5-hydroxy indole derivatives for treating glaucoma
WO2001070745A1 (en) * 2000-03-17 2001-09-27 Alcon, Inc. Pyranoindoles for treating glaucoma
EP1515730A4 (en) * 2002-06-17 2005-07-20 Merck & Co Inc NEW MAXI-K CHANNEL BLOCKS, USE METHOD AND METHOD FOR THE PRODUCTION THEREOF

Also Published As

Publication number Publication date
US7294646B2 (en) 2007-11-13
EP1515974A2 (en) 2005-03-23
US20050239863A1 (en) 2005-10-27
AU2003247533A1 (en) 2003-12-31
CA2488752A1 (en) 2003-12-24
WO2003105724A2 (en) 2003-12-24
AU2003247533B2 (en) 2008-09-18
EP1515974A4 (en) 2007-02-28
WO2003105724A3 (en) 2004-06-24

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