CA2488752A1 - Novel maxi-k channel blockers, methods of use and process for making the same - Google Patents

Novel maxi-k channel blockers, methods of use and process for making the same Download PDF

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Publication number
CA2488752A1
CA2488752A1 CA002488752A CA2488752A CA2488752A1 CA 2488752 A1 CA2488752 A1 CA 2488752A1 CA 002488752 A CA002488752 A CA 002488752A CA 2488752 A CA2488752 A CA 2488752A CA 2488752 A1 CA2488752 A1 CA 2488752A1
Authority
CA
Canada
Prior art keywords
compound
6alkyl
formula
pharmaceutically acceptable
tautomer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002488752A
Other languages
English (en)
French (fr)
Inventor
Maria L. Garcia
Michael A. Goetz
Gregory J. Kaczorowski
Owen B. Mcmanus
Richard L. Monaghan
William R. Strohl
Jan S. Tkacz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2488752A1 publication Critical patent/CA2488752A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA002488752A 2002-06-17 2003-06-13 Novel maxi-k channel blockers, methods of use and process for making the same Abandoned CA2488752A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38922202P 2002-06-17 2002-06-17
US60/389,222 2002-06-17
PCT/US2003/018842 WO2003105724A2 (en) 2002-06-17 2003-06-13 Novel maxi-k channel blockers, methods of use and process for making the same

Publications (1)

Publication Number Publication Date
CA2488752A1 true CA2488752A1 (en) 2003-12-24

Family

ID=29736611

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002488752A Abandoned CA2488752A1 (en) 2002-06-17 2003-06-13 Novel maxi-k channel blockers, methods of use and process for making the same

Country Status (6)

Country Link
US (1) US7294646B2 (https=)
EP (1) EP1515974A4 (https=)
JP (1) JP2005533055A (https=)
AU (1) AU2003247533B2 (https=)
CA (1) CA2488752A1 (https=)
WO (1) WO2003105724A2 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7053085B2 (en) 2003-03-26 2006-05-30 Merck & Co. Inc. EP4 receptor agonist, compositions and methods thereof
US20090148527A1 (en) * 2007-12-07 2009-06-11 Robinson Michael R Intraocular formulation
PT1905452E (pt) * 2005-07-12 2013-07-16 Kowa Co Agente para a prevenção ou tratamento do glaucoma
WO2009048559A1 (en) * 2007-10-11 2009-04-16 Merck & Co., Inc. Maxi-k channel blockers and methods of use
WO2009048558A1 (en) * 2007-10-11 2009-04-16 Merck & Co., Inc. Maxi-k channel blockers and methods of use
US8299079B2 (en) 2009-05-22 2012-10-30 Kaufman Herbert E Preparations and methods for ameliorating or reducing presbyopia
CN109593074B (zh) * 2017-09-30 2020-07-28 华中科技大学 真菌次生代谢产物中具有抗菌活性化合物的分离制备及用途

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4416890A (en) 1981-07-13 1983-11-22 Merck & Co., Inc. Benzothiazolesulfonamide derivatives for the topical treatment of elevated intraocular pressure
US4386098A (en) 1981-11-03 1983-05-31 Merck & Co., Inc. 6-Hydroxy-2-benzothiazolesulfonamide for the topical treatment of elevated intraocular pressure
US4426388A (en) 1982-04-02 1984-01-17 Merck & Co., Inc. 5-Benzothiazolesulfonamide derivatives for the topical treatment of elevated intraocular pressure
US4599353A (en) 1982-05-03 1986-07-08 The Trustees Of Columbia University In The City Of New York Use of eicosanoids and their derivatives for treatment of ocular hypertension and glaucoma
US4668697A (en) 1983-10-31 1987-05-26 Merck & Co., Inc. Elevated intraocular pressure lowering benzo-[b]-thiophene-2-sulfonamide derivatives, compositions, and method of use therefor
US4863922A (en) 1984-12-12 1989-09-05 Merck & Co., Inc. Substituted aromatic sulfonamides as antiglaucoma agents, compositions and use
US4797413A (en) 1986-05-14 1989-01-10 Merck & Co., Inc. Thieno thiopyran sulfonamide derivatives, pharmaceutical compositions and use
US4883819A (en) 1986-07-31 1989-11-28 The Trustees Of Columbia University In The City Of New York Use of A, B and C prostaglandins and derivatives thereof to treat ocular hypertension and glaucoma
US4824857A (en) 1986-05-16 1989-04-25 Yasumasa Goh Use of prostaglandin D2 -active substances
DE3850676T2 (de) 1987-09-18 1994-11-03 Ueno Seiyaku Oyo Kenkyujo Kk Hypotensive okulare Mittel.
AU3693789A (en) 1988-05-10 1989-11-29 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) New ophthalmic preparation for treating glaucoma
US5153192A (en) 1990-04-09 1992-10-06 Alcon Laboratories, Inc. Thiophene sulfonamides useful as carbonic anhydrase inhibitors
US5378703A (en) 1990-04-09 1995-01-03 Alcon Laboratories, Inc. Sulfonamides useful as carbonic anhydrase inhibitors
US5227396A (en) * 1991-07-19 1993-07-13 The United States Of America As Represented By The Secretary Of Agriculture Indole antiinsectan metabolites
AU7099194A (en) 1993-06-08 1995-01-03 Vide Pharmaceuticals Methods and compositions for lowering intraocular pressure
US5541208A (en) * 1994-01-24 1996-07-30 Merck & Co., Inc. Indole diterpene alkaloid compounds
US5573758A (en) 1995-04-28 1996-11-12 Allergan Method for reducing intraocular pressure in the mammalian eye by administration of potassium channel blockers
US5925342A (en) 1996-11-13 1999-07-20 Allergan Method for reducing intraocular pressure in the mammalian eye by administration of potassium channel blockers
US6548535B2 (en) * 2000-01-18 2003-04-15 Merck & Co., Inc. Method for treating ocular hypertension
WO2001070686A1 (en) * 2000-03-17 2001-09-27 Alcon, Inc. 5-hydroxy indole derivatives for treating glaucoma
WO2001070745A1 (en) * 2000-03-17 2001-09-27 Alcon, Inc. Pyranoindoles for treating glaucoma
EP1515730A4 (en) * 2002-06-17 2005-07-20 Merck & Co Inc NEW MAXI-K CHANNEL BLOCKS, USE METHOD AND METHOD FOR THE PRODUCTION THEREOF

Also Published As

Publication number Publication date
US7294646B2 (en) 2007-11-13
EP1515974A2 (en) 2005-03-23
US20050239863A1 (en) 2005-10-27
AU2003247533A1 (en) 2003-12-31
WO2003105724A2 (en) 2003-12-24
AU2003247533B2 (en) 2008-09-18
JP2005533055A (ja) 2005-11-04
EP1515974A4 (en) 2007-02-28
WO2003105724A3 (en) 2004-06-24

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued