JP2005533036A - 油性溶液の自己投与型避妊注射 - Google Patents

油性溶液の自己投与型避妊注射 Download PDF

Info

Publication number
JP2005533036A
JP2005533036A JP2004508891A JP2004508891A JP2005533036A JP 2005533036 A JP2005533036 A JP 2005533036A JP 2004508891 A JP2004508891 A JP 2004508891A JP 2004508891 A JP2004508891 A JP 2004508891A JP 2005533036 A JP2005533036 A JP 2005533036A
Authority
JP
Japan
Prior art keywords
ester
etonogestrel
ment
long
contraceptive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2004508891A
Other languages
English (en)
Japanese (ja)
Other versions
JP2005533036A5 (enExample
Inventor
デ・ネイス，ヘンリツク
フアン・デル・フオート，ヘンドリクス・アドリアヌス・アントニウス
レイセン，デイルク
Original Assignee
アクゾ・ノベル・エヌ・ベー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by アクゾ・ノベル・エヌ・ベー filed Critical アクゾ・ノベル・エヌ・ベー
Publication of JP2005533036A publication Critical patent/JP2005533036A/ja
Publication of JP2005533036A5 publication Critical patent/JP2005533036A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays or needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Reproductive Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
JP2004508891A 2002-05-30 2003-05-23 油性溶液の自己投与型避妊注射 Pending JP2005533036A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02077126 2002-05-30
PCT/EP2003/050192 WO2003101539A1 (en) 2002-05-30 2003-05-23 Self-administered contraceptive injection of oily solution

Publications (2)

Publication Number Publication Date
JP2005533036A true JP2005533036A (ja) 2005-11-04
JP2005533036A5 JP2005533036A5 (enExample) 2006-07-06

Family

ID=29595016

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004508891A Pending JP2005533036A (ja) 2002-05-30 2003-05-23 油性溶液の自己投与型避妊注射

Country Status (23)

Country Link
US (1) US20060094698A1 (enExample)
EP (1) EP1513587A1 (enExample)
JP (1) JP2005533036A (enExample)
KR (1) KR20050010014A (enExample)
CN (1) CN1298330C (enExample)
AR (1) AR040131A1 (enExample)
AU (1) AU2003238084A1 (enExample)
BR (1) BR0311423A (enExample)
CA (1) CA2487639A1 (enExample)
HR (1) HRP20041126A2 (enExample)
IL (1) IL165204A0 (enExample)
IS (1) IS7539A (enExample)
MX (1) MXPA04011928A (enExample)
NO (1) NO20044976L (enExample)
NZ (1) NZ536735A (enExample)
PE (1) PE20040676A1 (enExample)
PL (1) PL373074A1 (enExample)
RS (1) RS100904A (enExample)
RU (1) RU2328289C2 (enExample)
TW (1) TW200404552A (enExample)
UA (1) UA80822C2 (enExample)
WO (1) WO2003101539A1 (enExample)
ZA (1) ZA200409646B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022523819A (ja) * 2019-03-06 2022-04-26 プロペラ セラピューティクス インコーポレイテッド アビラテロンプロドラッグ

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200727920A (en) * 2005-06-21 2007-08-01 Organon Nv New regimens for oral monophasic contraceptives
KR20150011346A (ko) 2012-04-06 2015-01-30 안타레스 팔마, 인코퍼레이티드 테스토스테론 조성물의 바늘-보조식 젯 주입 투여 장치 및 방법
WO2014093818A2 (en) * 2012-12-14 2014-06-19 Bioject, Inc. Use of a novel subcutaneous needle-free technique to deliver testosterone in hypogonadal men
DK2953667T3 (da) * 2013-02-11 2020-01-27 Antares Pharma Inc Nålestøttet jetinjektionsindretning med reduceret udløserkraft
WO2015023557A1 (en) 2013-08-12 2015-02-19 Nanomedical Systems, Inc. Device and method for sustained release of low water solubility therapeutic agent in solubilizer
CN111057120B (zh) * 2019-12-27 2021-04-27 苏州翔实医药发展有限公司 一种依托孕烯衍生物a及其制备方法和用途

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2970153A (en) * 1959-07-27 1961-01-31 Leo Ab Alkoxyphenyl-propionyl esters of 17alpha-hydroxyprogesterone
JPH11509222A (ja) * 1995-07-17 1999-08-17 シェリング アクチェンゲゼルシャフト １３−エチル−１７β−ヒドロキシ−１１−メチレン−１８，１９−ジノル−１７α−プレグン−４−エン−２０−イン−３−オンのエステルを含む経皮投与のための剤
WO1999067271A1 (en) * 1998-06-19 1999-12-29 Akzo Nobel N.V. Testosterone derivative
WO1999067270A1 (en) * 1998-06-19 1999-12-29 Akzo Nobel N.V. Cycloalkyl-carboxylic acid esters of 7.alpha.methyl-estr-4-en-3-one 17.beta.-ol (19-nor 7.alpha.-methyltestosterone)
WO2001060376A1 (en) * 2000-02-15 2001-08-23 Schering Aktiengesellschaft Male contraceptive formulation comprising norethisterone

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3836862A1 (de) * 1988-10-27 1990-05-03 Schering Ag Mittel zur transdermalen applikation von steroidhormonen
CN1102095A (zh) * 1993-10-30 1995-05-03 浙江医科大学 长效雄激素类制剂——十一酸睾丸注射液
CN1135716A (zh) * 1993-12-27 1996-11-13 阿克佐诺贝尔公司 经皮吸收的药用制剂
US5599302A (en) * 1995-01-09 1997-02-04 Medi-Ject Corporation Medical injection system and method, gas spring thereof and launching device using gas spring
GB0000313D0 (en) * 2000-01-10 2000-03-01 Astrazeneca Uk Ltd Formulation
MXPA03001147A (es) * 2000-08-23 2003-10-06 Akzo Nobel Nv Nueva formulacion de ester de testosterona para uso humano.

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2970153A (en) * 1959-07-27 1961-01-31 Leo Ab Alkoxyphenyl-propionyl esters of 17alpha-hydroxyprogesterone
JPH11509222A (ja) * 1995-07-17 1999-08-17 シェリング アクチェンゲゼルシャフト １３−エチル−１７β−ヒドロキシ−１１−メチレン−１８，１９−ジノル−１７α−プレグン−４−エン−２０−イン−３−オンのエステルを含む経皮投与のための剤
WO1999067271A1 (en) * 1998-06-19 1999-12-29 Akzo Nobel N.V. Testosterone derivative
WO1999067270A1 (en) * 1998-06-19 1999-12-29 Akzo Nobel N.V. Cycloalkyl-carboxylic acid esters of 7.alpha.methyl-estr-4-en-3-one 17.beta.-ol (19-nor 7.alpha.-methyltestosterone)
WO2001060376A1 (en) * 2000-02-15 2001-08-23 Schering Aktiengesellschaft Male contraceptive formulation comprising norethisterone

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JPN6009057427, Ｋａｍｉｓｃｈｋｅ Ａ ｅｔ ａｌ, "Ａｎ ｅｆｆｅｃｔｉｖｅ ｈｏｒｍｏｎａｌ ｍａｌｅ ｃｏｎｔｒａｃｅｐｔｉｖｅ ｕｓｉｎｇ ｔｅｓｔｏｓｔｅｒｏｎｅ ｕｎｄｅｃａｎｏａｔｅ ｗｉｔｈ ｏｒａｌ ｏｒ ｉｎｊｅｃｔａｂｌｅ ｎｏｒｅ", Ｊ Ｃｌｉｎ Ｅｎｄｏｃｒｉｎｏｌ Ｍｅｔａｂ, 200202, ８７（２）, ５３０−９ *
JPN6009057428, Ｓｈｅｔｔｙ Ｇ ｅｔ ａｌ, "Ｕｓｅ ｏｆ ｎｏｒｅｔｈｉｓｔｅｒｏｎｅ ａｎｄ ｅｓｔｒａｄｉｏｌ ｉｎ ｍｉｎｉ ｄｏｓｅｓ ａｓ ａ ｃｏｎｔｒａｃｅｐｔｉｖｅ ｉｎ ｔｈｅ ｍａｌｅ． Ｅｆｆｉｃａｃｙ ｓｔｕｄｉｅｓ ｉ", Ｃｏｎｔｒａｃｅｐｔｉｏｎ, 1997, ５６（４）, ２５７−６５ *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022523819A (ja) * 2019-03-06 2022-04-26 プロペラ セラピューティクス インコーポレイテッド アビラテロンプロドラッグ
US12138273B2 (en) 2019-03-06 2024-11-12 Propella Therapeutics, Inc. Abiraterone prodrugs
JP7644713B2 (ja) 2019-03-06 2025-03-12 プロペラ セラピューティクス インコーポレイテッド アビラテロンプロドラッグ

Also Published As

Publication number Publication date
RU2328289C2 (ru) 2008-07-10
CN1655847A (zh) 2005-08-17
PE20040676A1 (es) 2004-09-25
IS7539A (is) 2004-11-18
BR0311423A (pt) 2005-03-15
CN1298330C (zh) 2007-02-07
MXPA04011928A (es) 2005-03-31
IL165204A0 (en) 2005-12-18
US20060094698A1 (en) 2006-05-04
TW200404552A (en) 2004-04-01
KR20050010014A (ko) 2005-01-26
EP1513587A1 (en) 2005-03-16
UA80822C2 (en) 2007-11-12
CA2487639A1 (en) 2003-12-11
RU2004138811A (ru) 2005-06-10
AU2003238084A1 (en) 2003-12-19
AR040131A1 (es) 2005-03-16
HRP20041126A2 (en) 2005-04-30
NO20044976L (no) 2004-12-23
WO2003101539A1 (en) 2003-12-11
RS100904A (sr) 2006-10-27
NZ536735A (en) 2007-01-26
ZA200409646B (en) 2006-06-28
PL373074A1 (en) 2005-08-08

Similar Documents

Publication Publication Date Title
JP4680891B2 (ja) 許容可能な血清中テストステロン・レベルを信頼性高く達成するための方法及び医薬組成物
RU2325910C2 (ru) Новые сложные эфиры этоногестрела
CA2415349A1 (en) Testosterone ester formulation for human use
AU2001291775A1 (en) Testosterone ester formulation for human use
RU2328289C2 (ru) Контрацептивная инъекция масляного раствора, вводимая самостоятельно
AU2003246740B2 (en) Use of new etonogestrel esters
CA2623477C (en) Compositions and method for treating pediatric hypogonadism
HK1072568B (en) Use of new etonogestrel esters

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20060517

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20060517

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A711

Effective date: 20070416

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20091117

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20100427