JP2005531001A5 - - Google Patents
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- JP2005531001A5 JP2005531001A5 JP2004516154A JP2004516154A JP2005531001A5 JP 2005531001 A5 JP2005531001 A5 JP 2005531001A5 JP 2004516154 A JP2004516154 A JP 2004516154A JP 2004516154 A JP2004516154 A JP 2004516154A JP 2005531001 A5 JP2005531001 A5 JP 2005531001A5
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- 238000000034 method Methods 0.000 claims 30
- 239000003446 ligand Substances 0.000 claims 27
- 239000000758 substrate Substances 0.000 claims 21
- 239000007790 solid phase Substances 0.000 claims 14
- 102000004169 proteins and genes Human genes 0.000 claims 12
- 238000003556 assay Methods 0.000 claims 11
- 230000004913 activation Effects 0.000 claims 10
- 108090000623 proteins and genes Proteins 0.000 claims 10
- 238000000159 protein binding assay Methods 0.000 claims 9
- 229920001971 elastomer Polymers 0.000 claims 8
- 239000000806 elastomer Substances 0.000 claims 8
- 239000012530 fluid Substances 0.000 claims 7
- 230000003213 activating effect Effects 0.000 claims 6
- 239000003153 chemical reaction reagent Substances 0.000 claims 6
- 239000007787 solid Substances 0.000 claims 6
- 108091034117 Oligonucleotide Proteins 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 5
- 239000000523 sample Substances 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 4
- 239000012488 sample solution Substances 0.000 claims 4
- 108090000790 Enzymes Proteins 0.000 claims 3
- 102000004190 Enzymes Human genes 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 230000003287 optical effect Effects 0.000 claims 3
- 230000001105 regulatory effect Effects 0.000 claims 3
- 108091005461 Nucleic proteins Proteins 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 229910021645 metal ion Inorganic materials 0.000 claims 2
- 239000012071 phase Substances 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 238000012286 ELISA Assay Methods 0.000 claims 1
- 101710120037 Toxin CcdB Proteins 0.000 claims 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 1
- 238000002802 antimicrobial activity assay Methods 0.000 claims 1
- 238000010822 cell death assay Methods 0.000 claims 1
- 210000000170 cell membrane Anatomy 0.000 claims 1
- 238000001516 cell proliferation assay Methods 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 238000005530 etching Methods 0.000 claims 1
- 238000002875 fluorescence polarization Methods 0.000 claims 1
- 238000002866 fluorescence resonance energy transfer Methods 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 230000007774 longterm Effects 0.000 claims 1
- 102000044158 nucleic acid binding protein Human genes 0.000 claims 1
- 108700020942 nucleic acid binding protein Proteins 0.000 claims 1
- 238000005192 partition Methods 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 231100000331 toxic Toxicity 0.000 claims 1
- 230000002588 toxic effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39129202P | 2002-06-24 | 2002-06-24 | |
| PCT/US2003/019775 WO2004000721A2 (en) | 2002-06-24 | 2003-06-23 | Recirculating fluidic network and methods for using the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005531001A JP2005531001A (ja) | 2005-10-13 |
| JP2005531001A5 true JP2005531001A5 (enExample) | 2006-07-27 |
Family
ID=30000688
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004516154A Pending JP2005531001A (ja) | 2002-06-24 | 2003-06-23 | 再循環流体ネットワークおよびその使用法 |
Country Status (5)
| Country | Link |
|---|---|
| US (4) | US20060086309A1 (enExample) |
| EP (1) | EP1535066A2 (enExample) |
| JP (1) | JP2005531001A (enExample) |
| AU (1) | AU2003277853A1 (enExample) |
| WO (1) | WO2004000721A2 (enExample) |
Families Citing this family (119)
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|---|---|---|---|---|
| US6221654B1 (en) | 1996-09-25 | 2001-04-24 | California Institute Of Technology | Method and apparatus for analysis and sorting of polynucleotides based on size |
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| US8052792B2 (en) | 2001-04-06 | 2011-11-08 | California Institute Of Technology | Microfluidic protein crystallography techniques |
| US7144616B1 (en) | 1999-06-28 | 2006-12-05 | California Institute Of Technology | Microfabricated elastomeric valve and pump systems |
| US7459022B2 (en) | 2001-04-06 | 2008-12-02 | California Institute Of Technology | Microfluidic protein crystallography |
| US7306672B2 (en) | 2001-04-06 | 2007-12-11 | California Institute Of Technology | Microfluidic free interface diffusion techniques |
| US8709153B2 (en) | 1999-06-28 | 2014-04-29 | California Institute Of Technology | Microfludic protein crystallography techniques |
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| AU2001290879A1 (en) | 2000-09-15 | 2002-03-26 | California Institute Of Technology | Microfabricated crossflow devices and methods |
| AU2002230524A1 (en) | 2000-11-16 | 2002-05-27 | California Institute Of Technology | Apparatus and methods for conducting assays and high throughput screening |
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| JP4346893B2 (ja) * | 2002-11-01 | 2009-10-21 | 株式会社日立製作所 | 化学反応装置 |
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- 2003-06-23 JP JP2004516154A patent/JP2005531001A/ja active Pending
- 2003-06-23 EP EP03742152A patent/EP1535066A2/en not_active Withdrawn
- 2003-06-23 US US10/517,942 patent/US20060086309A1/en not_active Abandoned
- 2003-06-23 US US10/602,489 patent/US8168139B2/en not_active Expired - Fee Related
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2012
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2014
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