JP2005530771A5 - - Google Patents
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- Publication number
- JP2005530771A5 JP2005530771A5 JP2004503057A JP2004503057A JP2005530771A5 JP 2005530771 A5 JP2005530771 A5 JP 2005530771A5 JP 2004503057 A JP2004503057 A JP 2004503057A JP 2004503057 A JP2004503057 A JP 2004503057A JP 2005530771 A5 JP2005530771 A5 JP 2005530771A5
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- JP
- Japan
- Prior art keywords
- different
- same
- complex
- complex according
- unsubstituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000027455 binding Effects 0.000 description 7
- 102000006495 integrins Human genes 0.000 description 7
- 108010044426 integrins Proteins 0.000 description 7
- 108020004707 nucleic acids Proteins 0.000 description 7
- 150000007523 nucleic acids Chemical class 0.000 description 7
- 229940088623 Biologically Active Substance Drugs 0.000 description 6
- 229910052736 halogen Inorganic materials 0.000 description 6
- 150000002367 halogens Chemical class 0.000 description 6
- 125000001183 hydrocarbyl group Chemical group 0.000 description 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 6
- 125000001424 substituent group Chemical group 0.000 description 6
- 150000002632 lipids Chemical class 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 239000004215 Carbon black (E152) Substances 0.000 description 3
- 150000002430 hydrocarbons Chemical group 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 229920001184 polypeptide Polymers 0.000 description 3
- OYHQOLUKZRVURQ-IXWMQOLASA-N Linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 description 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N Oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N Palmitic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N Stearic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
- -1 Substituted Chemical group 0.000 description 2
- 125000002947 alkylene group Chemical group 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229940079593 drugs Drugs 0.000 description 2
- 235000019197 fats Nutrition 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000001264 neutralization Effects 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000001890 transfection Methods 0.000 description 2
- 125000006832 (C1-C10) alkylene group Chemical group 0.000 description 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 description 1
- 229920000160 (ribonucleotides)n+m Polymers 0.000 description 1
- DXYNJHYPRKUMLM-WRBBJXAJSA-N 2,3-bis[(Z)-octadec-9-enoxy]propyl-[2-[2-(2-hydroxyethoxy)ethoxy]ethyl]-dimethylazanium Chemical compound CCCCCCCC\C=C/CCCCCCCCOCC(C[N+](C)(C)CCOCCOCCO)OCCCCCCCC\C=C/CCCCCCCC DXYNJHYPRKUMLM-WRBBJXAJSA-N 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- 235000021314 Palmitic acid Nutrition 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000000692 anti-sense Effects 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000038129 antigens Human genes 0.000 description 1
- 108091007172 antigens Proteins 0.000 description 1
- 229920003013 deoxyribonucleic acid Polymers 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000002068 genetic Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000003834 intracellular Effects 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 235000020778 linoleic acid Nutrition 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000006011 modification reaction Methods 0.000 description 1
- 235000021313 oleic acid Nutrition 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
- 229960005486 vaccines Drugs 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0210538.5A GB0210538D0 (en) | 2002-05-08 | 2002-05-08 | Lipids and gene delivery |
| PCT/GB2003/001985 WO2003094974A1 (en) | 2002-05-08 | 2003-05-08 | Complexes for the delivery of biologically-active material to cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005530771A JP2005530771A (ja) | 2005-10-13 |
| JP2005530771A5 true JP2005530771A5 (ko) | 2006-06-22 |
Family
ID=9936285
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004503057A Pending JP2005530771A (ja) | 2002-05-08 | 2003-05-08 | 生物学的活性物質の細胞への運搬に適した複合体 |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1506019A1 (ko) |
| JP (1) | JP2005530771A (ko) |
| AU (1) | AU2003240997A1 (ko) |
| GB (1) | GB0210538D0 (ko) |
| WO (1) | WO2003094974A1 (ko) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0313132D0 (en) | 2003-06-06 | 2003-07-09 | Ich Productions Ltd | Peptide ligands |
| WO2005117985A2 (en) * | 2004-06-02 | 2005-12-15 | Ucl Biomedica Plc | Lipopolyplex construct with an integrin binding peptide for delivery of nucleic acids, peptides or drugs |
| US20240038340A1 (en) * | 2020-08-31 | 2024-02-01 | Takeda Pharmaceutical Company Limited | Inference device, inference method, inference program, model generating method, inference service providing system, inference service providing method, and inference service providing program |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5527928A (en) * | 1994-09-30 | 1996-06-18 | Nantz; Michael H. | Cationic transport reagents |
| ATE195181T1 (de) * | 1995-09-11 | 2000-08-15 | Jolla Cancer Res Found | Moleküle, die sich in ausgewählten organen oder geweben invivo einfinden und verfahren zu ihrer identifizierung |
| AU7078396A (en) * | 1995-09-27 | 1997-04-30 | Regents Of The University Of California, The | Polyfunctional cationic cytofectins, formulations and methods for generating active cytofectin:polynucleotide transfection complexes |
| US5869715A (en) * | 1995-09-27 | 1999-02-09 | The Reagents Of The University Of California | Polyfunctional cationic cytofectins |
| GB9711115D0 (en) * | 1997-05-29 | 1997-07-23 | Inst Of Child Health | Integrin-targeting vectors having enhanced transfection activity |
| ATE549032T1 (de) * | 1999-03-26 | 2012-03-15 | Vical Inc | Adjuvanzverbindungen zur verbesserung von immunreaktionen auf polynukleotid-basierten impfstoffen |
| JP4723097B2 (ja) * | 1999-05-28 | 2011-07-13 | バイカル インコーポレイテッド | サイトフェクチン二量体およびその使用方法 |
-
2002
- 2002-05-08 GB GBGB0210538.5A patent/GB0210538D0/en not_active Ceased
-
2003
- 2003-05-08 AU AU2003240997A patent/AU2003240997A1/en not_active Abandoned
- 2003-05-08 EP EP03730315A patent/EP1506019A1/en not_active Withdrawn
- 2003-05-08 JP JP2004503057A patent/JP2005530771A/ja active Pending
- 2003-05-08 WO PCT/GB2003/001985 patent/WO2003094974A1/en active Application Filing
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