JP2005529590A5 - - Google Patents
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- JP2005529590A5 JP2005529590A5 JP2003584709A JP2003584709A JP2005529590A5 JP 2005529590 A5 JP2005529590 A5 JP 2005529590A5 JP 2003584709 A JP2003584709 A JP 2003584709A JP 2003584709 A JP2003584709 A JP 2003584709A JP 2005529590 A5 JP2005529590 A5 JP 2005529590A5
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- protein
- hur
- mrna
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- 102000055765 ELAV-Like Protein 1 Human genes 0.000 claims description 23
- 108020004999 messenger RNA Proteins 0.000 claims description 18
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- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37320702P | 2002-04-17 | 2002-04-17 | |
| PCT/EP2003/004008 WO2003087815A2 (en) | 2002-04-17 | 2003-04-16 | Method for the identification of inhibitors of the binding of are-containing mrn a and an hur protein |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005529590A JP2005529590A (ja) | 2005-10-06 |
| JP2005529590A5 true JP2005529590A5 (cg-RX-API-DMAC7.html) | 2006-06-08 |
Family
ID=29250994
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003584709A Pending JP2005529590A (ja) | 2002-04-17 | 2003-04-16 | ＡＲＥ含有ｍＲＮＡとＨｕＲタンパク質の結合のインヒビターの同定方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US7399583B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1497327A2 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2005529590A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2003226820A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2003087815A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9068234B2 (en) | 2003-01-21 | 2015-06-30 | Ptc Therapeutics, Inc. | Methods and agents for screening for compounds capable of modulating gene expression |
| US8460864B2 (en) | 2003-01-21 | 2013-06-11 | Ptc Therapeutics, Inc. | Methods for identifying compounds that modulate untranslated region-dependent gene expression and methods of using same |
| US8426194B2 (en) | 2003-01-21 | 2013-04-23 | Ptc Therapeutics, Inc. | Methods and agents for screening for compounds capable of modulating VEGF expression |
| DE10353803A1 (de) * | 2003-11-14 | 2005-06-23 | Oligene Gmbh | Diagnostische, prognostische und therapeutische Verfahren bei der Untersuchung und Therapie maligner Tumoren |
| US7767689B2 (en) | 2004-03-15 | 2010-08-03 | Ptc Therapeutics, Inc. | Carboline derivatives useful in the treatment of cancer |
| US7601840B2 (en) | 2004-03-15 | 2009-10-13 | Ptc Therapeutics, Inc. | Carboline derivatives useful in the inhibition of angiogenesis |
| US8076353B2 (en) | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Inhibition of VEGF translation |
| US8076352B2 (en) | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Administration of carboline derivatives useful in the treatment of cancer and other diseases |
| EP1859278A1 (en) * | 2005-03-03 | 2007-11-28 | Novartis AG | Method for the screening of compounds that modulate the interaction between mrna and proteins and compounds obtainable thereby |
| US8283115B1 (en) | 2007-06-20 | 2012-10-09 | Ptc Therapeutics, Inc. | Methods of screening for compounds for treating muscular dystrophy using UTRN mRNA translation regulation |
| US8283116B1 (en) | 2007-06-22 | 2012-10-09 | Ptc Therapeutics, Inc. | Methods of screening for compounds for treating spinal muscular atrophy using SMN mRNA translation regulation |
| KR20100012714A (ko) * | 2008-07-29 | 2010-02-08 | 재단법인서울대학교산학협력재단 | Ｒｎａ 분자와 단백질 사이의 상호작용을 조절하는 물질을동정하기 위한 분석 방법 |
| US20100209341A1 (en) | 2009-02-18 | 2010-08-19 | Csl Limited | Treatment of chronic inflammatory conditions |
| CN102821815A (zh) * | 2010-02-18 | 2012-12-12 | Csl有限公司 | 慢性炎症状态的治疗 |
| EP2600901B1 (en) | 2010-08-06 | 2019-03-27 | ModernaTX, Inc. | A pharmaceutical formulation comprising engineered nucleic acids and medical use thereof |
| MX2013003681A (es) | 2010-10-01 | 2013-11-20 | Moderna Therapeutics Inc | Ácidos nucleicos manipulados y métodos de uso de los mismos. |
| WO2012135805A2 (en) | 2011-03-31 | 2012-10-04 | modeRNA Therapeutics | Delivery and formulation of engineered nucleic acids |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| US9428535B2 (en) | 2011-10-03 | 2016-08-30 | Moderna Therapeutics, Inc. | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
| SMT202200355T1 (it) | 2011-12-16 | 2022-11-18 | Modernatx Inc | Composizioni di mrna modificato |
| EP2834260A4 (en) | 2012-04-02 | 2016-08-10 | Moderna Therapeutics Inc | MODIFIED POLYNUCLEOTIDES FOR THE PREPARATION OF MEMBRANE PROTEINS |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US10501512B2 (en) | 2012-04-02 | 2019-12-10 | Modernatx, Inc. | Modified polynucleotides |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| EP2922554B1 (en) | 2012-11-26 | 2022-02-23 | ModernaTX, Inc. | Terminally modified rna |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| EP3052106A4 (en) | 2013-09-30 | 2017-07-19 | ModernaTX, Inc. | Polynucleotides encoding immune modulating polypeptides |
| JP2016538829A (ja) | 2013-10-03 | 2016-12-15 | モデルナ セラピューティクス インコーポレイテッドＭｏｄｅｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | 低密度リポタンパク質受容体をコードするポリヌクレオチド |
| CN117448332B (zh) * | 2023-08-07 | 2025-06-24 | 大连理工大学 | 一种利用RNA结合蛋白增强mRNA蛋白表达的序列优化方法 |
Family Cites Families (15)
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|---|---|---|---|---|
| US5444149A (en) * | 1992-05-11 | 1995-08-22 | Duke University | Methods and compositions useful in the recognition, binding and expression of ribonucleic acids involved in cell growth, neoplasia and immunoregulation |
| US5733728A (en) | 1995-08-18 | 1998-03-31 | Regents Of The University Of Colorado | Detecting and treating heart failure |
| US6107029A (en) | 1996-07-31 | 2000-08-22 | Message Pharmaceticals, Inc. | Universal method for detecting interactions between RNA molecules and RNA binding proteins |
| US6180604B1 (en) * | 1996-08-21 | 2001-01-30 | Micrologix Biotech Inc. | Compositions and methods for treating infections using analogues of indolicidin |
| JP2001514511A (ja) | 1997-03-05 | 2001-09-11 | スクリプトゲン ファーマシューティカルズ インク | 核酸への親和性を持つ化合物同定のための蛍光異方性を用いたスクリーニング |
| CA2229449A1 (en) * | 1997-04-25 | 1998-10-25 | Takeda Chemical Industries, Ltd. | Novel receptor protein and its use |
| JP3793624B2 (ja) * | 1997-06-24 | 2006-07-05 | 株式会社リコー | 回転型現像装置 |
| AU766146B2 (en) | 1998-05-26 | 2003-10-09 | University Of Medicine And Dentistry Of New Jersey | System for reproducing and modulating stability and turnover of RNA molecules |
| GB9828709D0 (en) | 1998-12-24 | 1999-02-17 | Novartis Ag | Assay |
| WO2000067023A1 (en) | 1999-04-29 | 2000-11-09 | Coley Pharmaceutical Gmbh | Screening for immunostimulatory dna functional modifyers |
| AU6638800A (en) | 1999-08-13 | 2001-03-13 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Ttp-related zinc finger domains and methods of use |
| US20020127550A1 (en) | 1999-11-10 | 2002-09-12 | Anthony Giordano | Nucleic acid sequences and methods for identifying compounds that affect rna/rna binding protein interactions and mrna functionality |
| AUPQ483599A0 (en) | 1999-12-23 | 2000-02-03 | University Of Western Australia, The | Mrna binding motif |
| WO2001083691A2 (en) | 2000-04-12 | 2001-11-08 | The Cleveland Clinic Foundation | System for identifying and analyzing expression of are-containing genes |
| GB2370273A (en) * | 2000-12-20 | 2002-06-26 | Viaxxel Biotech Gmbh | Compounds that affect CD83 expression |
-
2003
- 2003-04-16 WO PCT/EP2003/004008 patent/WO2003087815A2/en not_active Ceased
- 2003-04-16 AU AU2003226820A patent/AU2003226820A1/en not_active Abandoned
- 2003-04-16 US US10/510,413 patent/US7399583B2/en not_active Expired - Fee Related
- 2003-04-16 EP EP03746306A patent/EP1497327A2/en not_active Withdrawn
- 2003-04-16 JP JP2003584709A patent/JP2005529590A/ja active Pending
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