JP2005528319A5 - - Google Patents

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JP2005528319A5
JP2005528319A5 JP2003512448A JP2003512448A JP2005528319A5 JP 2005528319 A5 JP2005528319 A5 JP 2005528319A5 JP 2003512448 A JP2003512448 A JP 2003512448A JP 2003512448 A JP2003512448 A JP 2003512448A JP 2005528319 A5 JP2005528319 A5 JP 2005528319A5
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cells
transduced
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marking
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JP2003512448A
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JP5179697B2 (ja
JP2005528319A (ja
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Priority claimed from PCT/US2002/021907 external-priority patent/WO2003006691A1/en
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Publication of JP2005528319A5 publication Critical patent/JP2005528319A5/ja
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両ベクターについて、注入した形質導入ＣＤ３４＋細胞の数とＰＢＭＣ（ＬＮＬ６ ｐ＝０．０２１、ＲＲｚ２ ｐ＝０．０２４）及びＴリンパ球（ＬＮＬ６及びＲＲｚ２の両方についてｐ＜０．００１）に注入して２年後の遺伝子検出における保持との間には強い線形相関が認められた。スピアマンの順位相関を使用して、再導入された形質導入細胞の数と子孫ＰＢＭＣ及びＴリンパ球のその後のマーキングとの間の関係を明示した。分析は、各患者の細胞／ｋｇで与えられた値に基づいた。これらの分析において、ＬＮＬ６マーキングは再導入されたＬＮＬ６形質導入細胞の量と相関しており、ＲＲｚ２マーキングは再導入したＲＲｚ２形質導入細胞の量と相関していた。１年よりも長くマーキングをもたらす形質導入ＣＤ３４＋細胞の最低数は、０．５ｘ１０6細胞／ｋｇであった。
JP2003512448A 2001-07-10 2002-07-10 造血前駆細胞を遺伝的に改変する方法及び改変された細胞の使用 Expired - Fee Related JP5179697B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US30428301P 2001-07-10 2001-07-10
US30412701P 2001-07-10 2001-07-10
US60/304,127 2001-07-10
US60/304,283 2001-07-10
US34348401P 2001-12-21 2001-12-21
US60/343,484 2001-12-21
US38606302P 2002-06-04 2002-06-04
US60/386,063 2002-06-04
PCT/US2002/021907 WO2003006691A1 (en) 2001-07-10 2002-07-10 Methods for genetic modification of hematopoietic progenitor cells and uses of the modified cells

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2009211662A Division JP2010077125A (ja) 2001-07-10 2009-09-14 造血前駆細胞を遺伝的に改変する方法及び改変された細胞の使用

Publications (3)

Publication Number Publication Date
JP2005528319A JP2005528319A (ja) 2005-09-22
JP2005528319A5 true JP2005528319A5 (ja) 2012-09-27
JP5179697B2 JP5179697B2 (ja) 2013-04-10

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ID=27501852

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JP2003512448A Expired - Fee Related JP5179697B2 (ja) 2001-07-10 2002-07-10 造血前駆細胞を遺伝的に改変する方法及び改変された細胞の使用
JP2009211662A Pending JP2010077125A (ja) 2001-07-10 2009-09-14 造血前駆細胞を遺伝的に改変する方法及び改変された細胞の使用

Family Applications After (1)

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JP2009211662A Pending JP2010077125A (ja) 2001-07-10 2009-09-14 造血前駆細胞を遺伝的に改変する方法及び改変された細胞の使用

Country Status (16)

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US (2) US7345025B2 (ja)
EP (2) EP2322618A1 (ja)
JP (2) JP5179697B2 (ja)
KR (1) KR101015913B1 (ja)
CN (2) CN101926824A (ja)
AT (1) ATE490322T1 (ja)
AU (1) AU2002316640C1 (ja)
BR (1) BR0211079A (ja)
CA (1) CA2453531A1 (ja)
DE (1) DE60238486D1 (ja)
DK (1) DK1414996T3 (ja)
HK (1) HK1065074A1 (ja)
IL (2) IL159637A0 (ja)
MX (1) MXPA04000268A (ja)
NZ (1) NZ530624A (ja)
WO (1) WO2003006691A1 (ja)

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