JP2005527834A5 - - Google Patents
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- Publication number
- JP2005527834A5 JP2005527834A5 JP2004509410A JP2004509410A JP2005527834A5 JP 2005527834 A5 JP2005527834 A5 JP 2005527834A5 JP 2004509410 A JP2004509410 A JP 2004509410A JP 2004509410 A JP2004509410 A JP 2004509410A JP 2005527834 A5 JP2005527834 A5 JP 2005527834A5
- Authority
- JP
- Japan
- Prior art keywords
- solution
- patient
- blood
- nitric oxide
- oxygen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims 14
- 239000000243 solution Substances 0.000 claims 12
- 239000008280 blood Substances 0.000 claims 11
- 210000004369 blood Anatomy 0.000 claims 7
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 239000001301 oxygen Substances 0.000 claims 6
- 229910052760 oxygen Inorganic materials 0.000 claims 6
- IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 claims 4
- 210000000601 blood cell Anatomy 0.000 claims 4
- 210000003743 erythrocyte Anatomy 0.000 claims 4
- 238000001802 infusion Methods 0.000 claims 4
- 210000002216 heart Anatomy 0.000 claims 3
- 210000004072 lung Anatomy 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 229910002651 NO3 Inorganic materials 0.000 claims 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims 1
- 230000017531 blood circulation Effects 0.000 claims 1
- 239000007789 gas Substances 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- GQPLMRYTRLFLPF-UHFFFAOYSA-N nitrous oxide Inorganic materials [O-][N+]#N GQPLMRYTRLFLPF-UHFFFAOYSA-N 0.000 claims 1
- 238000006213 oxygenation reaction Methods 0.000 claims 1
- 230000001575 pathological effect Effects 0.000 claims 1
- 230000004962 physiological condition Effects 0.000 claims 1
- 230000000304 vasodilatating effect Effects 0.000 claims 1
- 229940124549 vasodilator Drugs 0.000 claims 1
- 239000003071 vasodilator agent Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38359502P | 2002-05-29 | 2002-05-29 | |
| PCT/US2003/013409 WO2003102575A1 (en) | 2002-05-29 | 2003-05-27 | Measuring nitric oxide in blood gases and treatments based thereon |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005527834A JP2005527834A (ja) | 2005-09-15 |
| JP2005527834A5 true JP2005527834A5 (https=) | 2006-07-13 |
Family
ID=29711927
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004509410A Pending JP2005527834A (ja) | 2002-05-29 | 2003-05-27 | 血液ガス中の一酸化窒素の測定およびそれに基づく処置 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20060088942A1 (https=) |
| EP (1) | EP1514103A4 (https=) |
| JP (1) | JP2005527834A (https=) |
| AU (1) | AU2003232019A1 (https=) |
| CA (1) | CA2487719A1 (https=) |
| WO (1) | WO2003102575A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5305554B2 (ja) | 2002-12-12 | 2013-10-02 | デューク ユニバーシティ | 鉄ニトロシル化ヘモグロビンの生成 |
| JP5564158B2 (ja) | 2003-07-09 | 2014-07-30 | ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ アズ リプレゼンテッド バイ ザ セクレタリー オブ ザ デパートメント オブ ヘルス アンド ヒューマン サービシーズ | 亜硝酸塩によって特定の心臓血管状態を処置する方法 |
| US8551536B2 (en) | 2007-08-31 | 2013-10-08 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Nitrite and nitrite-metheme therapy to detoxify stroma-free hemoglobin based blood substitutes |
| RU2449783C2 (ru) * | 2010-08-02 | 2012-05-10 | Государственное образовательное учреждение высшего профессионального образования "Курский государственный медицинский университет Федерального агентства по здравоохранению и социальному развитию" | Способ коррекции l-name индуцированного дефицита оксида азота l-норвалином в эксперименте |
| JP6389125B2 (ja) * | 2011-11-07 | 2018-09-12 | ザ ジェネラル ホスピタル コーポレイション | 赤血球の処理法 |
| RU2500040C1 (ru) * | 2012-04-12 | 2013-11-27 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Курский государственный медицинский университет" Министерства здравоохранения и социального развития Российской Федерации | Способ коррекции l-name индуцированного дефицита оксида азота комбинацией тадалафила и l-норвалина в эксперименте |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1875917A3 (en) * | 1990-12-05 | 2012-11-28 | The General Hospital Corporation | Use of NO for the treatment or prevention of reversible pulmonary vasoconstriction |
| US5459076A (en) * | 1992-04-22 | 1995-10-17 | Brigham And Women's Hospital | Method for detecting nitric oxide, nitrosonium equivalents, S-nitrosothiols and S-nitroso-proteins in biological systems |
| US5427797A (en) * | 1993-04-06 | 1995-06-27 | Brigham And Women's Hospital | Systemic effects of nitric oxide inhalation |
| US6153186A (en) * | 1995-09-15 | 2000-11-28 | Duke University Medical Center | Red blood cells loaded with S-nitrosothiol and uses therefor |
| US6197745B1 (en) * | 1995-09-15 | 2001-03-06 | Duke University | Methods for producing nitrosated hemoglobins and therapeutic uses therefor |
| US6916471B2 (en) * | 1995-09-15 | 2005-07-12 | Duke University | Red blood cells loaded with S-nitrosothiol and uses therefor |
| US5869539A (en) * | 1996-04-17 | 1999-02-09 | Board Of Regents, The University Of Texas System | Emulsions of perfluoro compounds as solvents for nitric oxide (NO) |
| US5885842A (en) * | 1996-11-08 | 1999-03-23 | Medinox, Inc. | Methods for the detection of nitric oxide in fluid media |
| JP2002513400A (ja) * | 1997-02-06 | 2002-05-08 | デューク ユニバーシティ メディカル センター | Ｎｏ修飾ヘモグロビンおよびそのための使用 |
| US6087087A (en) * | 1997-07-03 | 2000-07-11 | Takashi Yonetani | Treatment of hemoglobin with nitric oxide |
| US6314956B1 (en) * | 1999-09-08 | 2001-11-13 | Duke University | Pulmonary delivery of NO group-containing compound in gas form to treat respiratory, cardiac and blood disorders |
| US6472390B1 (en) * | 2001-11-13 | 2002-10-29 | Duke University | Use of therapeutic dosages for nitric oxide donors which do not significantly lower blood pressure or pulmonary artery pressure |
| WO2003066109A1 (en) * | 2002-02-08 | 2003-08-14 | Gambro, Inc. | Nitric oxide in a pathogen inactivation process |
-
2003
- 2003-05-27 US US10/516,250 patent/US20060088942A1/en not_active Abandoned
- 2003-05-27 WO PCT/US2003/013409 patent/WO2003102575A1/en not_active Ceased
- 2003-05-27 AU AU2003232019A patent/AU2003232019A1/en not_active Abandoned
- 2003-05-27 EP EP03756165A patent/EP1514103A4/en not_active Withdrawn
- 2003-05-27 CA CA002487719A patent/CA2487719A1/en not_active Abandoned
- 2003-05-27 JP JP2004509410A patent/JP2005527834A/ja active Pending
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