JP2011105728A5 - - Google Patents
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- Publication number
- JP2011105728A5 JP2011105728A5 JP2010271007A JP2010271007A JP2011105728A5 JP 2011105728 A5 JP2011105728 A5 JP 2011105728A5 JP 2010271007 A JP2010271007 A JP 2010271007A JP 2010271007 A JP2010271007 A JP 2010271007A JP 2011105728 A5 JP2011105728 A5 JP 2011105728A5
- Authority
- JP
- Japan
- Prior art keywords
- arginine
- subject
- composition
- ornithine
- use according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 7
- 239000004475 Arginine Substances 0.000 claims 6
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims 6
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 claims 6
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 claims 6
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 6
- 235000009697 arginine Nutrition 0.000 claims 6
- 229960003104 ornithine Drugs 0.000 claims 6
- 208000002815 pulmonary hypertension Diseases 0.000 claims 4
- 102000004452 Arginase Human genes 0.000 claims 3
- 108700024123 Arginases Proteins 0.000 claims 3
- 208000006673 asthma Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 208000007056 sickle cell anemia Diseases 0.000 claims 3
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 claims 2
- 229930064664 L-arginine Natural products 0.000 claims 2
- 235000014852 L-arginine Nutrition 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 2
- 238000007918 intramuscular administration Methods 0.000 claims 2
- 238000001990 intravenous administration Methods 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000007920 subcutaneous administration Methods 0.000 claims 2
- BJIJBGVXFCOKTG-WCCKRBBISA-N (2s)-2-amino-5-(diaminomethylideneamino)pentanoic acid;nitrous acid Chemical compound ON=O.OC(=O)[C@@H](N)CCCN=C(N)N BJIJBGVXFCOKTG-WCCKRBBISA-N 0.000 claims 1
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 claims 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 1
- 230000000202 analgesic effect Effects 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 229910002091 carbon monoxide Inorganic materials 0.000 claims 1
- 239000013068 control sample Substances 0.000 claims 1
- 229910052749 magnesium Inorganic materials 0.000 claims 1
- 239000011777 magnesium Substances 0.000 claims 1
- 238000010606 normalization Methods 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 230000002685 pulmonary effect Effects 0.000 claims 1
- 239000000523 sample Substances 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44737303P | 2003-02-14 | 2003-02-14 | |
| US60/447,373 | 2003-02-14 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006503579A Division JP4723476B2 (ja) | 2003-02-14 | 2004-02-13 | 上昇したアルギナーゼ状態を含む、低下した一酸化窒素バイオアベイラビリティに関連する状態の治療 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011105728A JP2011105728A (ja) | 2011-06-02 |
| JP2011105728A5 true JP2011105728A5 (https=) | 2012-02-23 |
Family
ID=32908431
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006503579A Expired - Fee Related JP4723476B2 (ja) | 2003-02-14 | 2004-02-13 | 上昇したアルギナーゼ状態を含む、低下した一酸化窒素バイオアベイラビリティに関連する状態の治療 |
| JP2010271007A Pending JP2011105728A (ja) | 2003-02-14 | 2010-12-06 | 上昇したアルギナーゼ状態を含む、低下した一酸化窒素バイオアベイラビリティに関連する状態の治療 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006503579A Expired - Fee Related JP4723476B2 (ja) | 2003-02-14 | 2004-02-13 | 上昇したアルギナーゼ状態を含む、低下した一酸化窒素バイオアベイラビリティに関連する状態の治療 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US7651846B2 (https=) |
| EP (2) | EP1596854A4 (https=) |
| JP (2) | JP4723476B2 (https=) |
| CA (2) | CA2833559A1 (https=) |
| WO (1) | WO2004073623A2 (https=) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4723476B2 (ja) | 2003-02-14 | 2011-07-13 | チルドレンズ ホスピタル アンド リサーチ センター アット オークランド | 上昇したアルギナーゼ状態を含む、低下した一酸化窒素バイオアベイラビリティに関連する状態の治療 |
| MXPA05009251A (es) * | 2003-03-04 | 2005-10-19 | Wyeth Corp | Composiciones y metodos para diagnosticar y tratar asma u otras enfermedades alergicas o inflamatorias. |
| WO2005107384A2 (en) * | 2004-03-31 | 2005-11-17 | Nitromed, Inc. | Methods for treating blood disorders with nitric oxide donor compounds |
| WO2006049286A1 (ja) * | 2004-11-02 | 2006-05-11 | Ajinomoto Co., Inc. | アレルギー性疾患予防・治療剤 |
| ATE517347T1 (de) | 2004-12-01 | 2011-08-15 | Childrens Hosp & Res Ct Oak | Diagnose von leiden in zusammenhang mit verminderter arginin-bioverfügbarkeit |
| WO2007005620A2 (en) * | 2005-07-01 | 2007-01-11 | The Johns Hopkins University | Arginase ii: a target treatment of aging heart and heart failure |
| US10042980B2 (en) | 2005-11-17 | 2018-08-07 | Gearbox Llc | Providing assistance related to health |
| US8532938B2 (en) | 2005-11-17 | 2013-09-10 | The Invention Science Fund I, Llc | Testing-dependent administration of a nutraceutical |
| US7827042B2 (en) | 2005-11-30 | 2010-11-02 | The Invention Science Fund I, Inc | Methods and systems related to transmission of nutraceutical associated information |
| US20080103746A1 (en) | 2005-11-30 | 2008-05-01 | Searete Llc, A Limited Liability Corporation | Systems and methods for pathogen detection and response |
| US10296720B2 (en) | 2005-11-30 | 2019-05-21 | Gearbox Llc | Computational systems and methods related to nutraceuticals |
| US7927787B2 (en) | 2006-06-28 | 2011-04-19 | The Invention Science Fund I, Llc | Methods and systems for analysis of nutraceutical associated components |
| US8340944B2 (en) | 2005-11-30 | 2012-12-25 | The Invention Science Fund I, Llc | Computational and/or control systems and methods related to nutraceutical agent selection and dosing |
| US20070299693A1 (en) * | 2006-06-23 | 2007-12-27 | Searete Llc, A Limited Liability Corporation | Customized visual marking for medication labeling |
| US7974856B2 (en) * | 2005-11-30 | 2011-07-05 | The Invention Science Fund I, Llc | Computational systems and methods related to nutraceuticals |
| US8000981B2 (en) | 2005-11-30 | 2011-08-16 | The Invention Science Fund I, Llc | Methods and systems related to receiving nutraceutical associated information |
| US8297028B2 (en) | 2006-06-14 | 2012-10-30 | The Invention Science Fund I, Llc | Individualized pharmaceutical selection and packaging |
| EP1895012A1 (en) | 2006-08-30 | 2008-03-05 | Universitätsklinikum Freiburg | Method for inducing tumor apoptosis by increasing nitric oxide levels |
| EP2083812B1 (en) * | 2006-11-21 | 2017-04-05 | Rijksuniversiteit Groningen | Use of arginase inhibitors in the treatment of asthma and allergic rhinitis |
| EP2376072A1 (en) * | 2008-12-29 | 2011-10-19 | Tartu Ülikool (University Of Tartu) | Arginase inhibitors for the treatment of depression |
| US9387185B2 (en) * | 2009-01-09 | 2016-07-12 | Christian-Albrechts-Universität Zu Kiel | N-ω-hydroxy-L-arginine derivatives for the treatment of diseases |
| KR101900016B1 (ko) * | 2009-03-12 | 2018-09-20 | 캔서 프리벤션 앤 큐어, 리미티드 | 폐 질환의 동정, 평가, 예방 및 치료 방법과, 성별에 기초하는 질환의 동정, 평가, 예방 및 치료를 포함하는 상기 방법의 키트 |
| NZ624963A (en) | 2009-04-29 | 2016-07-29 | Amarin Pharmaceuticals Ie Ltd | Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same |
| WO2012019127A2 (en) * | 2010-08-05 | 2012-02-09 | The Regents Of The University Of Colorado | Combination yeast-based immunotherapy and arginine therapy for the treatment of myeloid-derived supressor cell-associated diseases |
| RU2464019C1 (ru) * | 2011-05-31 | 2012-10-20 | Открытое акционерное общество "Новосибхимфарм" | Композиция, обладающая эндотелиопротекторным, вазодилатирующим и ангиопротекторным эффектом |
| JP6072686B2 (ja) | 2011-07-21 | 2017-02-01 | 和光純薬工業株式会社 | 血漿中アミノ酸分析用標準液 |
| US20130116325A1 (en) * | 2011-09-02 | 2013-05-09 | Mark Herthel | Compositions and methods for treating anhidrosis |
| GB201303649D0 (en) | 2013-03-01 | 2013-04-17 | Univ Aston | Hydrogen sulphide compounds |
| US10357469B2 (en) | 2015-02-18 | 2019-07-23 | Aston University | Diagnostic assay and treatment for preeclampsia |
| CU20200106A7 (es) | 2018-06-20 | 2021-08-06 | Axcella Health Inc | Composiciones y métodos para el tratamiento de hemoglobinopatías y talasemias |
| JP2022166334A (ja) | 2019-09-19 | 2022-11-02 | 国立大学法人 東京大学 | 鎌状赤血球症の改善及び／又は予防剤 |
| CA3169994A1 (en) * | 2020-02-04 | 2021-08-12 | Horizon Therapeutics Ireland Dac | Methods for the treatment of scleroderma and related conditions |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4096037A (en) * | 1976-05-24 | 1978-06-20 | Pitman-Moore, Inc. | Arginase test |
| US4507314A (en) | 1983-07-20 | 1985-03-26 | Midit, Societe Fiduciaire | Drug for treating affections provoked by a too high histamine level, of the gastroduodenal mucosa and allergic affections |
| JPS6359899A (ja) * | 1986-09-01 | 1988-03-15 | Advance Co Ltd | 癌診断方法及びキツト |
| EP0441119A3 (en) | 1990-01-09 | 1992-10-14 | Richard D. Levere | The use of l-arginine in the treatment of hypertension and other vascular disorders |
| US5354934A (en) | 1993-02-04 | 1994-10-11 | Amgen Inc. | Pulmonary administration of erythropoietin |
| US5891459A (en) | 1993-06-11 | 1999-04-06 | The Board Of Trustees Of The Leland Stanford Junior University | Enhancement of vascular function by modulation of endogenous nitric oxide production or activity |
| US6214876B1 (en) | 1994-07-21 | 2001-04-10 | Eli Lilly And Company | Indene-1-acetamide sPLA2 inhibitors |
| US5641800A (en) | 1994-07-21 | 1997-06-24 | Eli Lilly And Company | 1H-indole-1-functional sPLA2 inhibitors |
| JPH08333313A (ja) * | 1995-02-03 | 1996-12-17 | Omeara Pty Ltd | アミノ酸、カルニチン及びマグネシウム補充用合成物及びその合成方法 |
| US5514704A (en) | 1995-03-13 | 1996-05-07 | Eli Lilly And Company | Benzothiophenes to inhibit leukotrienes |
| US6127421A (en) | 1996-01-31 | 2000-10-03 | The Board Of Trustees Of The University Of Arkansas | In ovo use of L-arginine and salts thereof in the prevention and/or treatment of pulmonary hypertension syndrome in avians |
| JP3771644B2 (ja) * | 1996-09-17 | 2006-04-26 | 株式会社大塚製薬工場 | 末梢静脈投与用輸液 |
| JP3824716B2 (ja) * | 1996-09-17 | 2006-09-20 | 株式会社大塚製薬工場 | 中心静脈投与用輸液 |
| US6027713A (en) | 1997-03-06 | 2000-02-22 | Meri Charmyne Russell | Composition and method for the treatment of exercise induced pulmonary hemorrhage |
| WO1998058633A2 (en) | 1997-06-23 | 1998-12-30 | Queen's University At Kingston | Microdose therapy of vascular conditions by no donors |
| WO1999019295A1 (en) * | 1997-10-10 | 1999-04-22 | Trustees Of The University Of Pennsylvania | Compositions and methods for inhibiting arginase activity |
| WO1999043308A2 (en) | 1998-02-27 | 1999-09-02 | Marlene Rabinovitch | Treating pulmonary hypertension through tenascin suppression and elastase inhibition |
| US6277884B1 (en) * | 1998-06-01 | 2001-08-21 | Nitromed, Inc. | Treatment of sexual dysfunction with N-hydroxyguanidine compounds |
| US6436997B1 (en) * | 1998-06-01 | 2002-08-20 | Nitromed, Inc. | Endogenous nitric oxide synthesis under conditions of low oxygen tension |
| FR2791571B1 (fr) * | 1999-04-02 | 2002-10-04 | Sod Conseils Rech Applic | Association inhibiteur(s) de no synthase et antioxydant(s) metabolique(s) |
| US6359007B1 (en) | 1999-04-07 | 2002-03-19 | Chronorx, Llc | Clinical uses for L-arginine ascorbate and various metalloarginate complexes |
| FR2794647A1 (fr) * | 1999-06-11 | 2000-12-15 | Centre Nat Rech Scient | Compositions pharmaceutique comprenant du no ou au moins un compose capable de liberer ou d'induire la formation de no dans les cellules |
| FR2799790B1 (fr) | 1999-09-24 | 2001-11-23 | Inst Francais Du Petrole | Methode et systeme d'extraction, d'analyse et de mesure sur des constituants transportes par un fluide de forage |
| US6492550B2 (en) | 2000-02-18 | 2002-12-10 | Bristol-Myers Squibb Company | Alpha-substituted thio, -oxo trifluoromethylketones as phospholipase inhibitors |
| US6784178B2 (en) * | 2000-04-12 | 2004-08-31 | Cornell Research Foundation, Inc. | Pharmacotherapy for vascular dysfunction associated with deficient nitric oxide bioactivity |
| US6956131B2 (en) * | 2000-04-13 | 2005-10-18 | Pharmacia Corporation | 2-amino-3, 4 heptenoic compounds useful as nitric oxide synthase inhibitors |
| AU2001264729A1 (en) * | 2000-05-22 | 2001-12-03 | Nitromed, Inc. | Thromboxane inhibitors, compositions and methods of use related applications |
| DK1163904T3 (da) * | 2000-06-16 | 2006-08-14 | Matthias Dr Med Rath | Sammensætning til forebyggelse af glat muskelsygdom, der omfatter ascorbat, arginin og magnesium |
| JP2004502948A (ja) | 2000-07-06 | 2004-01-29 | ファル ダイアグノスティクス | アルギニン化合物の検出のための方法及びキット |
| NZ524869A (en) * | 2000-09-22 | 2005-06-24 | Mars Uk Ltd | Food supplement |
| US6686340B2 (en) * | 2001-06-19 | 2004-02-03 | Matthias Rath | Composition and method for prevention and treatment of health conditions caused by constriction of smooth muscle cells |
| AU2003218099A1 (en) * | 2002-03-12 | 2003-09-29 | Lsu Medical Center | Modulation of the immune response through the manipulation of arginine levels |
| ITMI20021594A1 (it) * | 2002-07-19 | 2004-01-19 | Danieli Off Mecc | Metodo e impianto per la laminazione a caldo di rotaie |
| JP4723476B2 (ja) | 2003-02-14 | 2011-07-13 | チルドレンズ ホスピタル アンド リサーチ センター アット オークランド | 上昇したアルギナーゼ状態を含む、低下した一酸化窒素バイオアベイラビリティに関連する状態の治療 |
| ATE517347T1 (de) | 2004-12-01 | 2011-08-15 | Childrens Hosp & Res Ct Oak | Diagnose von leiden in zusammenhang mit verminderter arginin-bioverfügbarkeit |
-
2004
- 2004-02-13 JP JP2006503579A patent/JP4723476B2/ja not_active Expired - Fee Related
- 2004-02-13 CA CA2833559A patent/CA2833559A1/en not_active Abandoned
- 2004-02-13 EP EP04711201A patent/EP1596854A4/en not_active Ceased
- 2004-02-13 WO PCT/US2004/004369 patent/WO2004073623A2/en not_active Ceased
- 2004-02-13 CA CA2515929A patent/CA2515929C/en not_active Expired - Fee Related
- 2004-02-13 EP EP11180824A patent/EP2397128A1/en not_active Withdrawn
- 2004-12-01 US US11/002,956 patent/US7651846B2/en not_active Expired - Lifetime
-
2010
- 2010-12-06 JP JP2010271007A patent/JP2011105728A/ja active Pending
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