JP2005527493A5 - - Google Patents
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- JP2005527493A5 JP2005527493A5 JP2003561639A JP2003561639A JP2005527493A5 JP 2005527493 A5 JP2005527493 A5 JP 2005527493A5 JP 2003561639 A JP2003561639 A JP 2003561639A JP 2003561639 A JP2003561639 A JP 2003561639A JP 2005527493 A5 JP2005527493 A5 JP 2005527493A5
- Authority
- JP
- Japan
- Prior art keywords
- photoreactive agent
- patient
- eye
- needle
- depot
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003795 chemical substances by application Substances 0.000 claims 33
- 210000001525 retina Anatomy 0.000 claims 12
- 206010003210 Arteriosclerosis Diseases 0.000 claims 5
- 208000037260 Atherosclerotic Plaque Diseases 0.000 claims 5
- 206010012689 Diabetic retinopathy Diseases 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 206010064930 age-related macular degeneration Diseases 0.000 claims 5
- 230000002491 angiogenic effect Effects 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 230000001969 hypertrophic effect Effects 0.000 claims 5
- 208000002780 macular degeneration Diseases 0.000 claims 5
- 230000001613 neoplastic effect Effects 0.000 claims 5
- 208000037803 restenosis Diseases 0.000 claims 5
- 230000005284 excitation Effects 0.000 claims 4
- 229920000642 polymer Polymers 0.000 claims 4
- -1 texaphyrin Chemical compound 0.000 claims 4
- 230000005856 abnormality Effects 0.000 claims 3
- 229940090046 jet injector Drugs 0.000 claims 3
- WJFKNYWRSNBZNX-UHFFFAOYSA-N 10H-phenothiazine Chemical compound C1=CC=C2NC3=CC=CC=C3SC2=C1 WJFKNYWRSNBZNX-UHFFFAOYSA-N 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 230000003287 optical effect Effects 0.000 claims 2
- 229950000688 phenothiazine Drugs 0.000 claims 2
- 238000002428 photodynamic therapy Methods 0.000 claims 2
- 230000004044 response Effects 0.000 claims 2
- 239000000523 sample Substances 0.000 claims 2
- ATNMPCPGYQSWBN-REOHCLBHSA-N (3s)-3-amino-4-chloro-4-oxobutanoic acid Chemical group ClC(=O)[C@@H](N)CC(O)=O ATNMPCPGYQSWBN-REOHCLBHSA-N 0.000 claims 1
- YOSZEPWSVKKQOV-UHFFFAOYSA-N 12h-benzo[a]phenoxazine Chemical compound C1=CC=CC2=C3NC4=CC=CC=C4OC3=CC=C21 YOSZEPWSVKKQOV-UHFFFAOYSA-N 0.000 claims 1
- MHIITNFQDPFSES-UHFFFAOYSA-N 25,26,27,28-tetrazahexacyclo[16.6.1.13,6.18,11.113,16.019,24]octacosa-1(25),2,4,6,8(27),9,11,13,15,17,19,21,23-tridecaene Chemical compound N1C(C=C2C3=CC=CC=C3C(C=C3NC(=C4)C=C3)=N2)=CC=C1C=C1C=CC4=N1 MHIITNFQDPFSES-UHFFFAOYSA-N 0.000 claims 1
- ZGXJTSGNIOSYLO-UHFFFAOYSA-N 88755TAZ87 Chemical compound NCC(=O)CCC(O)=O ZGXJTSGNIOSYLO-UHFFFAOYSA-N 0.000 claims 1
- GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 claims 1
- 108010003118 Bacteriochlorophylls Proteins 0.000 claims 1
- JUDGRMABQJKRPW-XIADSQHASA-N CCC1=C(/C=C2\N=C(/C(\CC3=O)=C(/[C@@H](CCC(O)=O)[C@@H]4C)\N/C\4=C\C(C(C)=C4C=C)=N/C\4=C4)C3=C\2C)NC/4=C1C Chemical compound CCC1=C(/C=C2\N=C(/C(\CC3=O)=C(/[C@@H](CCC(O)=O)[C@@H]4C)\N/C\4=C\C(C(C)=C4C=C)=N/C\4=C4)C3=C\2C)NC/4=C1C JUDGRMABQJKRPW-XIADSQHASA-N 0.000 claims 1
- 229960002749 aminolevulinic acid Drugs 0.000 claims 1
- BHPNXACHQYJJJS-UHFFFAOYSA-N bacteriochlorin Chemical compound N1C(C=C2N=C(C=C3NC(=C4)C=C3)CC2)=CC=C1C=C1CCC4=N1 BHPNXACHQYJJJS-UHFFFAOYSA-N 0.000 claims 1
- DSJXIQQMORJERS-AGGZHOMASA-M bacteriochlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC([C@H](CC)[C@H]3C)=[N+]4C3=CC3=C(C(C)=O)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 DSJXIQQMORJERS-AGGZHOMASA-M 0.000 claims 1
- 125000002091 cationic group Chemical group 0.000 claims 1
- SURLGNKAQXKNSP-DBLYXWCISA-N chlorin Chemical compound C\1=C/2\N/C(=C\C3=N/C(=C\C=4NC(/C=C\5/C=CC/1=N/5)=CC=4)/C=C3)/CC\2 SURLGNKAQXKNSP-DBLYXWCISA-N 0.000 claims 1
- 210000004087 cornea Anatomy 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- CEJANLKHJMMNQB-UHFFFAOYSA-M cryptocyanin Chemical compound [I-].C12=CC=CC=C2N(CC)C=CC1=CC=CC1=CC=[N+](CC)C2=CC=CC=C12 CEJANLKHJMMNQB-UHFFFAOYSA-M 0.000 claims 1
- 238000005401 electroluminescence Methods 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 238000001506 fluorescence spectroscopy Methods 0.000 claims 1
- MOFVSTNWEDAEEK-UHFFFAOYSA-M indocyanine green Chemical compound [Na+].[O-]S(=O)(=O)CCCCN1C2=CC=C3C=CC=CC3=C2C(C)(C)C1=CC=CC=CC=CC1=[N+](CCCCS([O-])(=O)=O)C2=CC=C(C=CC=C3)C3=C2C1(C)C MOFVSTNWEDAEEK-UHFFFAOYSA-M 0.000 claims 1
- 229960004657 indocyanine green Drugs 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- QDLAGTHXVHQKRE-UHFFFAOYSA-N lichenxanthone Natural products COC1=CC(O)=C2C(=O)C3=C(C)C=C(OC)C=C3OC2=C1 QDLAGTHXVHQKRE-UHFFFAOYSA-N 0.000 claims 1
- 230000031700 light absorption Effects 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 238000001126 phototherapy Methods 0.000 claims 1
- IEQIEDJGQAUEQZ-UHFFFAOYSA-N phthalocyanine Chemical compound N1C(N=C2C3=CC=CC=C3C(N=C3C4=CC=CC=C4C(=N4)N3)=N2)=C(C=CC=C2)C2=C1N=C1C2=CC=CC=C2C4=N1 IEQIEDJGQAUEQZ-UHFFFAOYSA-N 0.000 claims 1
- 150000004032 porphyrins Chemical class 0.000 claims 1
- BBNQQADTFFCFGB-UHFFFAOYSA-N purpurin Chemical compound C1=CC=C2C(=O)C3=C(O)C(O)=CC(O)=C3C(=O)C2=C1 BBNQQADTFFCFGB-UHFFFAOYSA-N 0.000 claims 1
- 230000004043 responsiveness Effects 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 238000013268 sustained release Methods 0.000 claims 1
- 239000012730 sustained-release form Substances 0.000 claims 1
- 229950003937 tolonium Drugs 0.000 claims 1
- HNONEKILPDHFOL-UHFFFAOYSA-M tolonium chloride Chemical compound [Cl-].C1=C(C)C(N)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 HNONEKILPDHFOL-UHFFFAOYSA-M 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35146002P | 2002-01-23 | 2002-01-23 | |
| PCT/US2003/002303 WO2003061696A2 (en) | 2002-01-23 | 2003-01-23 | Systems and methods for photodynamic therapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005527493A JP2005527493A (ja) | 2005-09-15 |
| JP2005527493A5 true JP2005527493A5 (enExample) | 2006-03-09 |
Family
ID=27613501
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003561639A Pending JP2005527493A (ja) | 2002-01-23 | 2003-01-23 | 光線力学療法のためのシステムおよび方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20030167033A1 (enExample) |
| EP (1) | EP1467760A2 (enExample) |
| JP (1) | JP2005527493A (enExample) |
| CA (1) | CA2473924A1 (enExample) |
| WO (1) | WO2003061696A2 (enExample) |
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-
2003
- 2003-01-23 EP EP03704019A patent/EP1467760A2/en not_active Withdrawn
- 2003-01-23 CA CA002473924A patent/CA2473924A1/en not_active Abandoned
- 2003-01-23 JP JP2003561639A patent/JP2005527493A/ja active Pending
- 2003-01-23 US US10/351,730 patent/US20030167033A1/en not_active Abandoned
- 2003-01-23 WO PCT/US2003/002303 patent/WO2003061696A2/en not_active Ceased
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