JP2005526863A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2005526863A5 JP2005526863A5 JP2003535708A JP2003535708A JP2005526863A5 JP 2005526863 A5 JP2005526863 A5 JP 2005526863A5 JP 2003535708 A JP2003535708 A JP 2003535708A JP 2003535708 A JP2003535708 A JP 2003535708A JP 2005526863 A5 JP2005526863 A5 JP 2005526863A5
- Authority
- JP
- Japan
- Prior art keywords
- och
- nhco
- conh
- independently
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000003118 aryl group Chemical group 0.000 claims description 24
- 230000001225 therapeutic effect Effects 0.000 claims description 22
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 20
- 230000003287 optical effect Effects 0.000 claims description 17
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 16
- 229910052739 hydrogen Inorganic materials 0.000 claims description 16
- 125000000217 alkyl group Chemical group 0.000 claims description 14
- 239000001257 hydrogen Substances 0.000 claims description 14
- 150000002431 hydrogen Chemical class 0.000 claims description 14
- 206010028980 Neoplasm Diseases 0.000 claims description 12
- 125000004103 aminoalkyl group Chemical group 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 11
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 11
- 125000003545 alkoxy group Chemical group 0.000 claims description 9
- ANRHNWWPFJCPAZ-UHFFFAOYSA-M thionine Chemical compound [Cl-].C1=CC(N)=CC2=[S+]C3=CC(N)=CC=C3N=C21 ANRHNWWPFJCPAZ-UHFFFAOYSA-M 0.000 claims description 9
- 150000001720 carbohydrates Chemical class 0.000 claims description 8
- 229910052757 nitrogen Inorganic materials 0.000 claims description 8
- 239000003504 photosensitizing agent Substances 0.000 claims description 8
- 235000000346 sugar Nutrition 0.000 claims description 8
- 150000008163 sugars Chemical class 0.000 claims description 8
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 7
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 7
- 230000000975 bioactive effect Effects 0.000 claims description 7
- 102000004169 proteins and genes Human genes 0.000 claims description 7
- 108090000623 proteins and genes Proteins 0.000 claims description 7
- 239000002184 metal Substances 0.000 claims description 6
- 230000002285 radioactive effect Effects 0.000 claims description 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 4
- 229940079593 drug Drugs 0.000 claims description 4
- 108010015899 Glycopeptides Proteins 0.000 claims description 3
- 102000002068 Glycopeptides Human genes 0.000 claims description 3
- 239000002738 chelating agent Substances 0.000 claims description 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 3
- 229910052736 halogen Inorganic materials 0.000 claims description 3
- 150000002367 halogens Chemical class 0.000 claims description 3
- 239000005556 hormone Substances 0.000 claims description 3
- 229940088597 hormone Drugs 0.000 claims description 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 3
- 150000002482 oligosaccharides Polymers 0.000 claims description 3
- 238000002560 therapeutic procedure Methods 0.000 claims description 3
- 238000000034 method Methods 0.000 claims 14
- 150000001875 compounds Chemical class 0.000 claims 8
- 238000003745 diagnosis Methods 0.000 claims 3
- PUUBADHCONCMPA-USOGPTGWSA-N 3-[(21S,22S)-11-ethyl-16-(1-hexoxyethyl)-4-hydroxy-12,17,21,26-tetramethyl-7,23,24,25-tetrazahexacyclo[18.2.1.15,8.110,13.115,18.02,6]hexacosa-1,4,6,8(26),9,11,13(25),14,16,18(24),19-undecaen-22-yl]propanoic acid Chemical group CCCCCCOC(C)C1=C(C2=NC1=CC3=NC(=CC4=C(C5=C(CC(=C6[C@H]([C@@H](C(=C2)N6)C)CCC(=O)O)C5=N4)O)C)C(=C3C)CC)C PUUBADHCONCMPA-USOGPTGWSA-N 0.000 claims 2
- VZGJNCHEUPMLPM-DGKZTOLNSA-N C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](N)CCC(N)=O)C(C)C)C1=CN=CN1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](N)CCC(N)=O)C(C)C)C1=CN=CN1 VZGJNCHEUPMLPM-DGKZTOLNSA-N 0.000 claims 2
- 108010062050 bombesin (7-14) Proteins 0.000 claims 2
- 238000003384 imaging method Methods 0.000 claims 2
- CFODQUSMSYDHBS-UHFFFAOYSA-N octreotate Chemical group O=C1NC(CC=2C=CC=CC=2)C(=O)NC(CC=2[C]3C=CC=CC3=NC=2)C(=O)NC(CCCCN)C(=O)NC(C(C)O)C(=O)NC(C(=O)NC(C(O)C)C(O)=O)CSSCC1NC(=O)C(N)CC1=CC=CC=C1 CFODQUSMSYDHBS-UHFFFAOYSA-N 0.000 claims 2
- 208000037260 Atherosclerotic Plaque Diseases 0.000 claims 1
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims 1
- 208000003788 Neoplasm Micrometastasis Diseases 0.000 claims 1
- 208000007536 Thrombosis Diseases 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 claims 1
- 238000000149 argon plasma sintering Methods 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 238000001839 endoscopy Methods 0.000 claims 1
- 238000004867 photoacoustic spectroscopy Methods 0.000 claims 1
- 238000002428 photodynamic therapy Methods 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 238000003325 tomography Methods 0.000 claims 1
- 239000000298 carbocyanine Substances 0.000 description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 125000000623 heterocyclic group Chemical group 0.000 description 2
- 229920001542 oligosaccharide Polymers 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 125000004434 sulfur atom Chemical group 0.000 description 2
- 125000000027 (C1-C10) alkoxy group Chemical group 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 125000002837 carbocyclic group Chemical group 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 150000002772 monosaccharides Chemical class 0.000 description 1
- 239000000816 peptidomimetic Substances 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/981,271 US20030105300A1 (en) | 2001-10-17 | 2001-10-17 | Tumor targeted photodiagnostic-phototherapeutic agents |
| PCT/US2002/032022 WO2003032902A2 (en) | 2001-10-17 | 2002-10-07 | Tumor targeted photodiagnostic-phototherapeutic agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005526863A JP2005526863A (ja) | 2005-09-08 |
| JP2005526863A5 true JP2005526863A5 (enExample) | 2006-01-12 |
Family
ID=25528252
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003535708A Pending JP2005526863A (ja) | 2001-10-17 | 2002-10-07 | 腫瘍標的光学診断用−光学治療用成分 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20030105300A1 (enExample) |
| EP (2) | EP2201897A3 (enExample) |
| JP (1) | JP2005526863A (enExample) |
| AU (1) | AU2002334891A1 (enExample) |
| CA (1) | CA2463911A1 (enExample) |
| WO (1) | WO2003032902A2 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7226577B2 (en) | 2003-01-13 | 2007-06-05 | Bracco Imaging, S. P. A. | Gastrin releasing peptide compounds |
| US20040247527A1 (en) * | 2003-03-10 | 2004-12-09 | Mpa Technologies, Inc. | Multifunctional photodynamic agents for treating of disease |
| AU2005275220B2 (en) * | 2004-07-16 | 2012-02-02 | Health Research, Inc. | Adduct of fluorescent dye and tumor avid tetrapyrrole |
| US20100056983A1 (en) * | 2007-09-27 | 2010-03-04 | Health Research, Inc. | Treatment of cancer using photodynamic therapy |
| US9433700B2 (en) | 2009-04-27 | 2016-09-06 | Medibeacon Inc. | Tissue sealant compositions, vascular closure devices, and uses thereof |
| US9186349B2 (en) | 2009-05-12 | 2015-11-17 | Mallinckrodt Llc | Diaza heterocyclic compounds for phototherapy |
| US8731655B2 (en) | 2009-05-12 | 2014-05-20 | Mallinckrodt Llc | Compounds containing acyclic N-N bonds for phototherapy |
| WO2011009020A2 (en) | 2009-07-16 | 2011-01-20 | Mallinckrodt Inc. | Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers |
| WO2015154094A1 (en) * | 2014-04-05 | 2015-10-08 | Zand Jason M | Apparatus, systems, and methods for mapping of tissue oxygenation |
| US9862682B2 (en) | 2016-01-08 | 2018-01-09 | BroadPharm | Functionalized pegylated cyanine compounds, pharmaceutical compositions, and methods of use thereof |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1989010758A1 (en) * | 1988-05-02 | 1989-11-16 | Zynaxis Technologies, Inc. | Compounds, compositions and method for binding bio-affecting substances to surface membranes of bio-particles |
| US5453505A (en) * | 1994-06-30 | 1995-09-26 | Biometric Imaging, Inc. | N-heteroaromatic ion and iminium ion substituted cyanine dyes for use as fluorescence labels |
| DE4445065A1 (de) | 1994-12-07 | 1996-06-13 | Diagnostikforschung Inst | Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung |
| JPH09227378A (ja) * | 1996-02-20 | 1997-09-02 | Fuji Photo Film Co Ltd | 抗癌性組成物 |
| DE19649971A1 (de) | 1996-11-19 | 1998-05-28 | Diagnostikforschung Inst | Optische Diagnostika zur Diagnostik neurodegenerativer Krankheiten mittels Nahinfrarot-Strahlung (NIR-Strahlung) |
| EP0979107A1 (en) | 1997-04-29 | 2000-02-16 | Nycomed Imaging As | Light imaging contrast agents |
| WO1998048838A1 (en) | 1997-04-29 | 1998-11-05 | Nycomed Imaging As | Compounds |
| US6217848B1 (en) * | 1999-05-20 | 2001-04-17 | Mallinckrodt Inc. | Cyanine and indocyanine dye bioconjugates for biomedical applications |
| US6395257B1 (en) * | 2000-01-18 | 2002-05-28 | Mallinckrodt Inc. | Dendrimer precursor dyes for imaging |
| US6939532B2 (en) * | 2000-01-18 | 2005-09-06 | Mallinckrodt, Inc. | Versatile hydrophilic dyes |
| WO2001052744A1 (en) * | 2000-01-18 | 2001-07-26 | Mallinckrodt Inc. | Hydrophilic cyanine dyes |
| US20030017164A1 (en) * | 2001-07-03 | 2003-01-23 | Mallinckrodt Inc. | Dye-azide compounds for dual phototherapy |
| US6180085B1 (en) * | 2000-01-18 | 2001-01-30 | Mallinckrodt Inc. | Dyes |
| US6180087B1 (en) * | 2000-01-18 | 2001-01-30 | Mallinckrodt Inc. | Tunable indocyanine dyes for biomedical applications |
| US6663847B1 (en) * | 2000-10-13 | 2003-12-16 | Mallinckrodt Inc. | Dynamic organ function monitoring agents |
| US6669926B1 (en) * | 2000-10-16 | 2003-12-30 | Mallinckrodt, Inc. | Hydrophilic light absorbing indole compounds for determination of physiological function in critically ill patients |
| US6656451B1 (en) * | 2000-10-16 | 2003-12-02 | Mallinckrodt, Inc. | Indole compounds as novel dyes for organ function monitoring |
| US6733744B1 (en) * | 2000-10-16 | 2004-05-11 | Mallinckrodt Inc. | Indole compounds as minimally invasive physiological function monitoring agents |
-
2001
- 2001-10-17 US US09/981,271 patent/US20030105300A1/en not_active Abandoned
-
2002
- 2002-10-07 AU AU2002334891A patent/AU2002334891A1/en not_active Abandoned
- 2002-10-07 JP JP2003535708A patent/JP2005526863A/ja active Pending
- 2002-10-07 EP EP10075038A patent/EP2201897A3/en not_active Withdrawn
- 2002-10-07 EP EP02801661A patent/EP1443861A4/en not_active Withdrawn
- 2002-10-07 CA CA002463911A patent/CA2463911A1/en not_active Abandoned
- 2002-10-07 WO PCT/US2002/032022 patent/WO2003032902A2/en not_active Ceased
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2005506344A5 (enExample) | ||
| JP2005506343A5 (enExample) | ||
| US6217848B1 (en) | Cyanine and indocyanine dye bioconjugates for biomedical applications | |
| ES2305444T3 (es) | Agente de contraste fluorescente del infrarrojo cercano y metodo para la formacion de imagenes por fluorescencia. | |
| US7201892B2 (en) | Pathological tissue detection and treatment employing targeted optical agents | |
| US7767194B2 (en) | Optical diagnostic and therapeutic agents and compositions | |
| JP2011116773A (ja) | 親水性シアニン染料 | |
| JP2003520288A5 (enExample) | ||
| JP2011051900A (ja) | 組込み型光活性ペプチドおよびその使用 | |
| JP2003520868A5 (enExample) | ||
| CN104245954A (zh) | 细菌成像剂及其使用方法 | |
| JP2003535041A (ja) | 広用途の親水性染料 | |
| JP2005506343A (ja) | 縦列的、光学診断的および治療的適用のためのカルボシアニン染料 | |
| JP2005526863A5 (enExample) | ||
| JP2003523371A5 (enExample) | ||
| WO2005000218A2 (en) | Macrocyclic cyanine and indocyanine bioconjugates provide improved biomedical applications | |
| JP2006503798A (ja) | 同時光学診断および治療適用のための染料バイオコンジュゲート | |
| JP2005526863A (ja) | 腫瘍標的光学診断用−光学治療用成分 | |
| JP2003529632A (ja) | 親水性シアニン染料 | |
| AGENT | Long-circulating Psma-targeted Phototheranostic Agent |