JP2005526863A - 腫瘍標的光学診断用−光学治療用成分 - Google Patents

腫瘍標的光学診断用−光学治療用成分 Download PDF

Info

Publication number
JP2005526863A
JP2005526863A JP2003535708A JP2003535708A JP2005526863A JP 2005526863 A JP2005526863 A JP 2005526863A JP 2003535708 A JP2003535708 A JP 2003535708A JP 2003535708 A JP2003535708 A JP 2003535708A JP 2005526863 A JP2005526863 A JP 2005526863A
Authority
JP
Japan
Prior art keywords
och
nhco
conh
independently
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2003535708A
Other languages
English (en)
Japanese (ja)
Other versions
JP2005526863A5 (enExample
Inventor
サミュエル・アイ・アチレフ
ラガバン・ラジャゴパラン
ジョゼフ・イー・ブガジュ
リチャード・ビー・ドーショー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Inc
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Publication of JP2005526863A publication Critical patent/JP2005526863A/ja
Publication of JP2005526863A5 publication Critical patent/JP2005526863A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0013Luminescence
    • A61K49/0017Fluorescence in vivo
    • A61K49/0019Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032Methine dyes, e.g. cyanine dyes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0013Luminescence
    • A61K49/0017Fluorescence in vivo
    • A61K49/0019Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032Methine dyes, e.g. cyanine dyes
    • A61K49/0034Indocyanine green, i.e. ICG, cardiogreen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0013Luminescence
    • A61K49/0017Fluorescence in vivo
    • A61K49/005Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0052Small organic molecules
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0013Luminescence
    • A61K49/0017Fluorescence in vivo
    • A61K49/005Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056Peptides, proteins, polyamino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0066Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain being part of a carbocyclic ring,(e.g. benzene, naphtalene, cyclohexene, cyclobutenene-quadratic acid)
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0075Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain being part of an heterocyclic ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Indole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
JP2003535708A 2001-10-17 2002-10-07 腫瘍標的光学診断用−光学治療用成分 Pending JP2005526863A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/981,271 US20030105300A1 (en) 2001-10-17 2001-10-17 Tumor targeted photodiagnostic-phototherapeutic agents
PCT/US2002/032022 WO2003032902A2 (en) 2001-10-17 2002-10-07 Tumor targeted photodiagnostic-phototherapeutic agents

Publications (2)

Publication Number Publication Date
JP2005526863A true JP2005526863A (ja) 2005-09-08
JP2005526863A5 JP2005526863A5 (enExample) 2006-01-12

Family

ID=25528252

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003535708A Pending JP2005526863A (ja) 2001-10-17 2002-10-07 腫瘍標的光学診断用−光学治療用成分

Country Status (6)

Country Link
US (1) US20030105300A1 (enExample)
EP (2) EP2201897A3 (enExample)
JP (1) JP2005526863A (enExample)
AU (1) AU2002334891A1 (enExample)
CA (1) CA2463911A1 (enExample)
WO (1) WO2003032902A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013500840A (ja) * 2009-08-06 2013-01-10 ヘルス リサーチ インコーポレイテッド 光力学療法を使用する癌の治療

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7226577B2 (en) 2003-01-13 2007-06-05 Bracco Imaging, S. P. A. Gastrin releasing peptide compounds
US20040247527A1 (en) * 2003-03-10 2004-12-09 Mpa Technologies, Inc. Multifunctional photodynamic agents for treating of disease
AU2005275220B2 (en) * 2004-07-16 2012-02-02 Health Research, Inc. Adduct of fluorescent dye and tumor avid tetrapyrrole
US9433700B2 (en) 2009-04-27 2016-09-06 Medibeacon Inc. Tissue sealant compositions, vascular closure devices, and uses thereof
US9186349B2 (en) 2009-05-12 2015-11-17 Mallinckrodt Llc Diaza heterocyclic compounds for phototherapy
US8731655B2 (en) 2009-05-12 2014-05-20 Mallinckrodt Llc Compounds containing acyclic N-N bonds for phototherapy
WO2011009020A2 (en) 2009-07-16 2011-01-20 Mallinckrodt Inc. Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
WO2015154094A1 (en) * 2014-04-05 2015-10-08 Zand Jason M Apparatus, systems, and methods for mapping of tissue oxygenation
US9862682B2 (en) 2016-01-08 2018-01-09 BroadPharm Functionalized pegylated cyanine compounds, pharmaceutical compositions, and methods of use thereof

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989010758A1 (en) * 1988-05-02 1989-11-16 Zynaxis Technologies, Inc. Compounds, compositions and method for binding bio-affecting substances to surface membranes of bio-particles
US5453505A (en) * 1994-06-30 1995-09-26 Biometric Imaging, Inc. N-heteroaromatic ion and iminium ion substituted cyanine dyes for use as fluorescence labels
DE4445065A1 (de) 1994-12-07 1996-06-13 Diagnostikforschung Inst Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung
JPH09227378A (ja) * 1996-02-20 1997-09-02 Fuji Photo Film Co Ltd 抗癌性組成物
DE19649971A1 (de) 1996-11-19 1998-05-28 Diagnostikforschung Inst Optische Diagnostika zur Diagnostik neurodegenerativer Krankheiten mittels Nahinfrarot-Strahlung (NIR-Strahlung)
EP0979107A1 (en) 1997-04-29 2000-02-16 Nycomed Imaging As Light imaging contrast agents
WO1998048838A1 (en) 1997-04-29 1998-11-05 Nycomed Imaging As Compounds
US6217848B1 (en) * 1999-05-20 2001-04-17 Mallinckrodt Inc. Cyanine and indocyanine dye bioconjugates for biomedical applications
US6395257B1 (en) * 2000-01-18 2002-05-28 Mallinckrodt Inc. Dendrimer precursor dyes for imaging
US6939532B2 (en) * 2000-01-18 2005-09-06 Mallinckrodt, Inc. Versatile hydrophilic dyes
WO2001052744A1 (en) * 2000-01-18 2001-07-26 Mallinckrodt Inc. Hydrophilic cyanine dyes
US20030017164A1 (en) * 2001-07-03 2003-01-23 Mallinckrodt Inc. Dye-azide compounds for dual phototherapy
US6180085B1 (en) * 2000-01-18 2001-01-30 Mallinckrodt Inc. Dyes
US6180087B1 (en) * 2000-01-18 2001-01-30 Mallinckrodt Inc. Tunable indocyanine dyes for biomedical applications
US6663847B1 (en) * 2000-10-13 2003-12-16 Mallinckrodt Inc. Dynamic organ function monitoring agents
US6669926B1 (en) * 2000-10-16 2003-12-30 Mallinckrodt, Inc. Hydrophilic light absorbing indole compounds for determination of physiological function in critically ill patients
US6656451B1 (en) * 2000-10-16 2003-12-02 Mallinckrodt, Inc. Indole compounds as novel dyes for organ function monitoring
US6733744B1 (en) * 2000-10-16 2004-05-11 Mallinckrodt Inc. Indole compounds as minimally invasive physiological function monitoring agents

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013500840A (ja) * 2009-08-06 2013-01-10 ヘルス リサーチ インコーポレイテッド 光力学療法を使用する癌の治療

Also Published As

Publication number Publication date
AU2002334891A1 (en) 2003-04-28
CA2463911A1 (en) 2003-04-24
EP2201897A2 (en) 2010-06-30
US20030105300A1 (en) 2003-06-05
EP2201897A3 (en) 2010-07-28
WO2003032902A3 (en) 2003-10-23
EP1443861A2 (en) 2004-08-11
WO2003032902A2 (en) 2003-04-24
EP1443861A4 (en) 2006-09-06

Similar Documents

Publication Publication Date Title
US6761878B2 (en) Pathological tissue detection and treatment employing targeted benzoindole optical agents
US6641798B2 (en) Tumor-targeted optical contrast agents
US7011817B2 (en) Hydrophilic cyanine dyes
US6706254B2 (en) Receptor-avid exogenous optical contrast and therapeutic agents
US7198778B2 (en) Tumor-targeted optical contrast agents
US20030105299A1 (en) Carbocyanine dyes for tandem, photodiagnostic and therapeutic applications
US6939532B2 (en) Versatile hydrophilic dyes
US20030152577A1 (en) Dye-bioconjugates for simultaneous optical diagnostic and therapeutic applications
JP2005526863A (ja) 腫瘍標的光学診断用−光学治療用成分
EP1250091B1 (en) Hydrophilic cyanine dyes

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20050929

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20050929

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20051027

RD02 Notification of acceptance of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7422

Effective date: 20080526

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20080625

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20080625

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20090624

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20091119