JP2005525325A5 - - Google Patents
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- Publication number
- JP2005525325A5 JP2005525325A5 JP2003564060A JP2003564060A JP2005525325A5 JP 2005525325 A5 JP2005525325 A5 JP 2005525325A5 JP 2003564060 A JP2003564060 A JP 2003564060A JP 2003564060 A JP2003564060 A JP 2003564060A JP 2005525325 A5 JP2005525325 A5 JP 2005525325A5
- Authority
- JP
- Japan
- Prior art keywords
- mmol
- stirred
- isonitrile
- vacuo
- aldehyde
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- 150000001412 amines Chemical class 0.000 description 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 150000002527 isonitriles Chemical class 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10204072A DE10204072A1 (de) | 2002-01-31 | 2002-01-31 | Neue Verbindungen, die Faktor Xa-Aktivität inhibieren |
| DE10300049A DE10300049A1 (de) | 2003-01-03 | 2003-01-03 | Neue Verbindungen, die Faktor VIIa inhibieren |
| PCT/EP2003/001011 WO2003064440A1 (de) | 2002-01-31 | 2003-01-31 | Verbindungen, die faktor xa-aktivät inhibieren |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005525325A JP2005525325A (ja) | 2005-08-25 |
| JP2005525325A5 true JP2005525325A5 (https=) | 2006-03-09 |
Family
ID=27664555
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003564060A Pending JP2005525325A (ja) | 2002-01-31 | 2003-01-31 | Ｘａ因子活性を阻害する化合物 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20050049283A1 (https=) |
| EP (1) | EP1470143B1 (https=) |
| JP (1) | JP2005525325A (https=) |
| KR (1) | KR20040096541A (https=) |
| CN (1) | CN1322001C (https=) |
| AT (1) | ATE377017T1 (https=) |
| BR (1) | BR0307266A (https=) |
| CA (1) | CA2473169A1 (https=) |
| DE (1) | DE50308492D1 (https=) |
| MX (1) | MXPA04007461A (https=) |
| NZ (1) | NZ534238A (https=) |
| PL (1) | PL369772A1 (https=) |
| WO (1) | WO2003064440A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20060135781A (ko) * | 2004-02-25 | 2006-12-29 | 라 졸라 파마슈티칼 컴파니 | 질병의 치료를 위한 아민 및 아미드 |
| ES2365815T3 (es) * | 2005-12-14 | 2011-10-11 | Bristol-Myers Squibb Company | Análogos de arilpropionamida, arilacrilamida, arilpropinamida o arilmetilurea como inhibidores del factor xia. |
| EP1981854B1 (en) | 2005-12-14 | 2011-06-01 | Bristol-Myers Squibb Company | Arylpropionamide, arylacrylamide, arylpropynamide, or arylmethylurea analogs as factor xia inhibitors |
| WO2017156071A1 (en) | 2016-03-09 | 2017-09-14 | Blade Therapeutics, Inc. | Cyclic keto-amide compounds as calpain modulators and methods of production and use thereof |
| EP3481835A4 (en) | 2016-07-05 | 2020-02-26 | Blade Therapeutics, Inc. | CALPAIN MODULATORS AND THERAPEUTIC USE THEREOF |
| BR112019006110A2 (pt) | 2016-09-28 | 2019-09-10 | Blade Therapeutics Inc | moduladores de calpaína e usos terapêuticos dos mesmos |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2614893B1 (fr) * | 1987-05-04 | 1989-12-22 | Fournier Innovation Synergie | Nouveaux b-d-phenyl-thioxylosides, leur procede de preparation et leur application en therapeutique |
| EP0560568A3 (en) * | 1992-03-13 | 1994-06-29 | Takeda Chemical Industries Ltd | Hydroquinone derivatives and intermediates for production thereof |
| EP0921116B1 (de) * | 1997-12-04 | 2003-06-18 | F. Hoffmann-La Roche Ag | N-(4-carbamimido-phenyl)-glycinamidderivate |
| US6358960B1 (en) * | 1998-02-17 | 2002-03-19 | Ono Pharmaceutical Co., Ltd. | Amidino derivatives and drugs containing the same as the active ingredient |
| US6486129B1 (en) * | 1998-06-17 | 2002-11-26 | Akzo Nobel N.V. | Antithrombotic compounds |
| DE10041402A1 (de) * | 2000-08-23 | 2002-03-14 | Morphochem Ag | Neue Verbindungen, die Faktor Xa-Aktivität inhibieren |
| PT1336605E (pt) * | 2000-11-22 | 2006-06-30 | Astellas Pharma Inc | Derivados de fenol substituidos ou seus sais como inibidores do factor x de coagulacao |
-
2003
- 2003-01-31 BR BR0307266-5A patent/BR0307266A/pt not_active IP Right Cessation
- 2003-01-31 NZ NZ534238A patent/NZ534238A/en unknown
- 2003-01-31 AT AT03734605T patent/ATE377017T1/de not_active IP Right Cessation
- 2003-01-31 US US10/501,932 patent/US20050049283A1/en not_active Abandoned
- 2003-01-31 JP JP2003564060A patent/JP2005525325A/ja active Pending
- 2003-01-31 DE DE50308492T patent/DE50308492D1/de not_active Expired - Fee Related
- 2003-01-31 KR KR10-2004-7011732A patent/KR20040096541A/ko not_active Withdrawn
- 2003-01-31 CN CNB038031558A patent/CN1322001C/zh not_active Expired - Fee Related
- 2003-01-31 EP EP03734605A patent/EP1470143B1/de not_active Expired - Lifetime
- 2003-01-31 WO PCT/EP2003/001011 patent/WO2003064440A1/de not_active Ceased
- 2003-01-31 CA CA002473169A patent/CA2473169A1/en not_active Abandoned
- 2003-01-31 PL PL03369772A patent/PL369772A1/xx not_active Application Discontinuation
- 2003-01-31 MX MXPA04007461A patent/MXPA04007461A/es active IP Right Grant