CN1322001C - 抑制因子Xa活性的新化合物 - Google Patents

抑制因子Xa活性的新化合物 Download PDF

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Publication number
CN1322001C
CN1322001C CNB038031558A CN03803155A CN1322001C CN 1322001 C CN1322001 C CN 1322001C CN B038031558 A CNB038031558 A CN B038031558A CN 03803155 A CN03803155 A CN 03803155A CN 1322001 C CN1322001 C CN 1322001C
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CN
China
Prior art keywords
phenyl
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group
replaces
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB038031558A
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English (en)
Chinese (zh)
Other versions
CN1625559A (zh
Inventor
罗伯特·埃克尔
西尔克·沙贝特
蒂洛·富克斯
卢茨·韦伯
克里斯蒂安·厄夫内尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Morphochem GmbH
Original Assignee
Morphochem AG fuer Kombinatorische Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10204072A external-priority patent/DE10204072A1/de
Priority claimed from DE10300049A external-priority patent/DE10300049A1/de
Application filed by Morphochem AG fuer Kombinatorische Chemie filed Critical Morphochem AG fuer Kombinatorische Chemie
Publication of CN1625559A publication Critical patent/CN1625559A/zh
Application granted granted Critical
Publication of CN1322001C publication Critical patent/CN1322001C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Genetics & Genomics (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CNB038031558A 2002-01-31 2003-01-31 抑制因子Xa活性的新化合物 Expired - Fee Related CN1322001C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE10204072.9 2002-01-31
DE10204072A DE10204072A1 (de) 2002-01-31 2002-01-31 Neue Verbindungen, die Faktor Xa-Aktivität inhibieren
DE10300049.6 2003-01-03
DE10300049A DE10300049A1 (de) 2003-01-03 2003-01-03 Neue Verbindungen, die Faktor VIIa inhibieren

Publications (2)

Publication Number Publication Date
CN1625559A CN1625559A (zh) 2005-06-08
CN1322001C true CN1322001C (zh) 2007-06-20

Family

ID=27664555

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB038031558A Expired - Fee Related CN1322001C (zh) 2002-01-31 2003-01-31 抑制因子Xa活性的新化合物

Country Status (13)

Country Link
US (1) US20050049283A1 (https=)
EP (1) EP1470143B1 (https=)
JP (1) JP2005525325A (https=)
KR (1) KR20040096541A (https=)
CN (1) CN1322001C (https=)
AT (1) ATE377017T1 (https=)
BR (1) BR0307266A (https=)
CA (1) CA2473169A1 (https=)
DE (1) DE50308492D1 (https=)
MX (1) MXPA04007461A (https=)
NZ (1) NZ534238A (https=)
PL (1) PL369772A1 (https=)
WO (1) WO2003064440A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20060135781A (ko) * 2004-02-25 2006-12-29 라 졸라 파마슈티칼 컴파니 질병의 치료를 위한 아민 및 아미드
ES2365815T3 (es) * 2005-12-14 2011-10-11 Bristol-Myers Squibb Company Análogos de arilpropionamida, arilacrilamida, arilpropinamida o arilmetilurea como inhibidores del factor xia.
EP1981854B1 (en) 2005-12-14 2011-06-01 Bristol-Myers Squibb Company Arylpropionamide, arylacrylamide, arylpropynamide, or arylmethylurea analogs as factor xia inhibitors
WO2017156071A1 (en) 2016-03-09 2017-09-14 Blade Therapeutics, Inc. Cyclic keto-amide compounds as calpain modulators and methods of production and use thereof
EP3481835A4 (en) 2016-07-05 2020-02-26 Blade Therapeutics, Inc. CALPAIN MODULATORS AND THERAPEUTIC USE THEREOF
BR112019006110A2 (pt) 2016-09-28 2019-09-10 Blade Therapeutics Inc moduladores de calpaína e usos terapêuticos dos mesmos

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0290321A1 (fr) * 1987-05-04 1988-11-09 Fournier Industrie Et Sante Nouveaux beta-D-phényl-thioxylosides, leur procédé de préparation et leur application en thérapeutique
EP0560568A2 (en) * 1992-03-13 1993-09-15 Takeda Chemical Industries, Ltd. Hydroquinone derivatives and intermediates for production thereof
EP0921116A1 (de) * 1997-12-04 1999-06-09 F. Hoffmann-La Roche Ag N-(4-carbamimido-phenyl)-glycinamidderivate
WO1999065934A1 (en) * 1998-06-17 1999-12-23 Akzo Nobel N.V. Antithrombotic compounds
EP1078917A1 (en) * 1998-02-17 2001-02-28 Ono Pharmaceutical Co., Ltd. Amidino derivatives and drugs containing the same as the active ingredient

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10041402A1 (de) * 2000-08-23 2002-03-14 Morphochem Ag Neue Verbindungen, die Faktor Xa-Aktivität inhibieren
PT1336605E (pt) * 2000-11-22 2006-06-30 Astellas Pharma Inc Derivados de fenol substituidos ou seus sais como inibidores do factor x de coagulacao

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0290321A1 (fr) * 1987-05-04 1988-11-09 Fournier Industrie Et Sante Nouveaux beta-D-phényl-thioxylosides, leur procédé de préparation et leur application en thérapeutique
EP0560568A2 (en) * 1992-03-13 1993-09-15 Takeda Chemical Industries, Ltd. Hydroquinone derivatives and intermediates for production thereof
EP0921116A1 (de) * 1997-12-04 1999-06-09 F. Hoffmann-La Roche Ag N-(4-carbamimido-phenyl)-glycinamidderivate
EP1078917A1 (en) * 1998-02-17 2001-02-28 Ono Pharmaceutical Co., Ltd. Amidino derivatives and drugs containing the same as the active ingredient
WO1999065934A1 (en) * 1998-06-17 1999-12-23 Akzo Nobel N.V. Antithrombotic compounds

Also Published As

Publication number Publication date
KR20040096541A (ko) 2004-11-16
JP2005525325A (ja) 2005-08-25
DE50308492D1 (de) 2007-12-13
NZ534238A (en) 2006-09-29
EP1470143B1 (de) 2007-10-31
US20050049283A1 (en) 2005-03-03
MXPA04007461A (es) 2005-07-13
ATE377017T1 (de) 2007-11-15
WO2003064440A1 (de) 2003-08-07
CA2473169A1 (en) 2003-08-07
CN1625559A (zh) 2005-06-08
BR0307266A (pt) 2004-12-07
PL369772A1 (en) 2005-05-02
EP1470143A1 (de) 2004-10-27

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee