JP2005524696A - Ｎｒ２ｂレセプターアンタゴニストとしての３，４−ジヒドロキノリン−２（１ｈ）−オン化合物。 - Google Patents
Ｎｒ２ｂレセプターアンタゴニストとしての３，４−ジヒドロキノリン−２（１ｈ）−オン化合物。 Download PDFInfo
- Publication number
- JP2005524696A JP2005524696A JP2003587800A JP2003587800A JP2005524696A JP 2005524696 A JP2005524696 A JP 2005524696A JP 2003587800 A JP2003587800 A JP 2003587800A JP 2003587800 A JP2003587800 A JP 2003587800A JP 2005524696 A JP2005524696 A JP 2005524696A
- Authority
- JP
- Japan
- Prior art keywords
- disease
- pharmaceutically acceptable
- compound
- pain
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 0 *c1cccc(C2(CCNCC2)O)c1 Chemical compound *c1cccc(C2(CCNCC2)O)c1 0.000 description 3
- RQKNHWVLFZRXBY-UHFFFAOYSA-N C1COCCOCCCNC1 Chemical compound C1COCCOCCCNC1 RQKNHWVLFZRXBY-UHFFFAOYSA-N 0.000 description 1
- FDCWDCYSJSNMNL-UHFFFAOYSA-N CC(C(c(cc1)cc(CC2)c1NC2=O)O)N(CC1)CCC1(c(cc1)ccc1F)O Chemical compound CC(C(c(cc1)cc(CC2)c1NC2=O)O)N(CC1)CCC1(c(cc1)ccc1F)O FDCWDCYSJSNMNL-UHFFFAOYSA-N 0.000 description 1
- NFWVCYWFUIFIKU-UHFFFAOYSA-N Nc(cc1)cc(CC2)c1NC2=O Chemical compound Nc(cc1)cc(CC2)c1NC2=O NFWVCYWFUIFIKU-UHFFFAOYSA-N 0.000 description 1
- CCMOBQFBGOEGEN-UHFFFAOYSA-N O=C(CBr)c(cc1)cc(CC2)c1NC2=O Chemical compound O=C(CBr)c(cc1)cc(CC2)c1NC2=O CCMOBQFBGOEGEN-UHFFFAOYSA-N 0.000 description 1
- QCDAGJBIPUQIER-UHFFFAOYSA-N O=C(CC1)Nc2c1cc(C(CBr)OP)cc2 Chemical compound O=C(CC1)Nc2c1cc(C(CBr)OP)cc2 QCDAGJBIPUQIER-UHFFFAOYSA-N 0.000 description 1
- KDWKPOXQEWDDRS-UHFFFAOYSA-N O=C(CC1)Nc2c1cc(C1OC1)cc2 Chemical compound O=C(CC1)Nc2c1cc(C1OC1)cc2 KDWKPOXQEWDDRS-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Virology (AREA)
- AIDS & HIV (AREA)
- Hospice & Palliative Care (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Psychology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37593902P | 2002-04-26 | 2002-04-26 | |
| PCT/IB2003/001556 WO2003091241A1 (en) | 2002-04-26 | 2003-04-15 | 3, 4-dihydroquinolin-2(1h)-one compounds as nr2b receptor antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005524696A true JP2005524696A (ja) | 2005-08-18 |
| JP2005524696A5 JP2005524696A5 (https=) | 2006-06-08 |
Family
ID=29270728
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003587800A Withdrawn JP2005524696A (ja) | 2002-04-26 | 2003-04-15 | Ｎｒ２ｂレセプターアンタゴニストとしての３，４−ジヒドロキノリン−２（１ｈ）−オン化合物。 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6713490B2 (https=) |
| EP (1) | EP1499606B8 (https=) |
| JP (1) | JP2005524696A (https=) |
| AR (1) | AR039663A1 (https=) |
| AT (1) | ATE325117T1 (https=) |
| AU (1) | AU2003219398A1 (https=) |
| BR (1) | BR0309778A (https=) |
| CA (1) | CA2483636A1 (https=) |
| DE (1) | DE60305026T2 (https=) |
| ES (1) | ES2258716T3 (https=) |
| MX (1) | MXPA04010549A (https=) |
| PA (1) | PA8572601A1 (https=) |
| TW (1) | TW200406402A (https=) |
| UY (1) | UY27776A1 (https=) |
| WO (1) | WO2003091241A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010532761A (ja) * | 2007-07-03 | 2010-10-14 | ノノ インコーポレイテッド | 不安に対する治療法 |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL126999A (en) | 1996-07-24 | 2002-03-10 | Warner Lambert Co | Pharmaceutical preparations containing isobutylgaba and its history for use in the treatment of pain |
| MXPA06003748A (es) * | 2003-10-08 | 2006-06-14 | Pfizer | Compuestos de lactama condensada. |
| ES2246687B2 (es) * | 2004-02-11 | 2006-11-16 | Miguel Muñoz Saez | Utilizacion de antagonistas no peptidicos de receptores nk1 para la produccion de apoptosis en celulas tumorales. |
| JPWO2005097782A1 (ja) * | 2004-04-07 | 2007-08-16 | 協和醗酵工業株式会社 | ピペリジン誘導体 |
| HU226977B1 (en) * | 2004-07-29 | 2010-04-28 | Richter Gedeon Nyrt | Kynurenic acid amide derivatives, pharmaceutical compositions containing them and process for producing them |
| WO2008027557A2 (en) * | 2006-08-31 | 2008-03-06 | Spherics, Inc. | Topiramate compositions and methods of enhancing its bioavailability |
| JP2010043063A (ja) | 2008-05-09 | 2010-02-25 | Agency For Science Technology & Research | 川崎病の診断及び治療 |
| EP2334176A4 (en) | 2008-09-27 | 2012-05-02 | Taraxos Inc | TOPICAL FORMULATIONS FOR THE TREATMENT OF NERVE DISEASES |
| US20120077883A1 (en) * | 2009-03-31 | 2012-03-29 | De Barros Coelho Claudia Couto | Treatment of tinnitus and associated auditory dysfunctions |
| WO2011145062A1 (en) | 2010-05-21 | 2011-11-24 | Link Research & Grants Corporation | Treatment of tinnitus and related auditory dysfunctions |
| WO2012042314A1 (en) | 2010-10-02 | 2012-04-05 | Link Research & Grants Corporation | Treatment of tinnitus and related auditory dysfunctions |
| AU2013251079B2 (en) | 2012-04-20 | 2017-03-23 | Ucb Pharma S.A. | Methods for treating Parkinson's disease |
| US20140206667A1 (en) | 2012-11-14 | 2014-07-24 | Michela Gallagher | Methods and compositions for treating schizophrenia |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4902695A (en) | 1989-02-13 | 1990-02-20 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
| KR0163355B1 (ko) | 1990-05-10 | 1998-12-01 | 알렌 제이. 스피겔 | 신경보호성 인돌론 및 관련 유도체 |
| US5852040A (en) | 1992-10-30 | 1998-12-22 | Pfizer Inc. | Neuroprotective 3,4-dihydro-2(1H)-quinolone compounds |
| PE20020291A1 (es) | 2000-08-21 | 2002-04-17 | Hoffmann La Roche | Profarmacos para ligandos del receptor nmda |
-
2003
- 2003-04-14 US US10/413,029 patent/US6713490B2/en not_active Expired - Fee Related
- 2003-04-15 AU AU2003219398A patent/AU2003219398A1/en not_active Abandoned
- 2003-04-15 MX MXPA04010549A patent/MXPA04010549A/es not_active Application Discontinuation
- 2003-04-15 JP JP2003587800A patent/JP2005524696A/ja not_active Withdrawn
- 2003-04-15 EP EP03715209A patent/EP1499606B8/en not_active Expired - Lifetime
- 2003-04-15 CA CA002483636A patent/CA2483636A1/en not_active Abandoned
- 2003-04-15 WO PCT/IB2003/001556 patent/WO2003091241A1/en not_active Ceased
- 2003-04-15 AT AT03715209T patent/ATE325117T1/de not_active IP Right Cessation
- 2003-04-15 BR BR0309778-1A patent/BR0309778A/pt not_active IP Right Cessation
- 2003-04-15 DE DE60305026T patent/DE60305026T2/de not_active Expired - Fee Related
- 2003-04-15 ES ES03715209T patent/ES2258716T3/es not_active Expired - Lifetime
- 2003-04-24 AR ARP030101424A patent/AR039663A1/es unknown
- 2003-04-24 UY UY27776A patent/UY27776A1/es not_active Application Discontinuation
- 2003-04-25 PA PA20038572601A patent/PA8572601A1/es unknown
- 2003-04-25 TW TW092109786A patent/TW200406402A/zh unknown
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010532761A (ja) * | 2007-07-03 | 2010-10-14 | ノノ インコーポレイテッド | 不安に対する治療法 |
| US8536129B2 (en) | 2007-07-03 | 2013-09-17 | Nono Inc. | Treatment for anxiety |
| JP2014129353A (ja) * | 2007-07-03 | 2014-07-10 | Nono Inc | 不安に対する治療法 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1499606B8 (en) | 2006-08-30 |
| PA8572601A1 (es) | 2004-12-16 |
| AU2003219398A1 (en) | 2003-11-10 |
| MXPA04010549A (es) | 2005-02-17 |
| US6713490B2 (en) | 2004-03-30 |
| DE60305026D1 (de) | 2006-06-08 |
| BR0309778A (pt) | 2005-03-08 |
| ES2258716T3 (es) | 2006-09-01 |
| TW200406402A (en) | 2004-05-01 |
| CA2483636A1 (en) | 2003-11-06 |
| WO2003091241A1 (en) | 2003-11-06 |
| EP1499606B1 (en) | 2006-05-03 |
| US20030216430A1 (en) | 2003-11-20 |
| DE60305026T2 (de) | 2006-10-12 |
| UY27776A1 (es) | 2003-11-28 |
| ATE325117T1 (de) | 2006-06-15 |
| AR039663A1 (es) | 2005-03-02 |
| EP1499606A1 (en) | 2005-01-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20060412 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20060412 |
|
| A761 | Written withdrawal of application |
Free format text: JAPANESE INTERMEDIATE CODE: A761 Effective date: 20061207 |