JP2005524614A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2005524614A5 JP2005524614A5 JP2003556023A JP2003556023A JP2005524614A5 JP 2005524614 A5 JP2005524614 A5 JP 2005524614A5 JP 2003556023 A JP2003556023 A JP 2003556023A JP 2003556023 A JP2003556023 A JP 2003556023A JP 2005524614 A5 JP2005524614 A5 JP 2005524614A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- solvent
- corticosteroid
- stearate
- emulsifier
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 93
- 238000000034 method Methods 0.000 claims description 56
- 239000003995 emulsifying agent Substances 0.000 claims description 40
- 239000002904 solvent Substances 0.000 claims description 40
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical group CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 39
- 239000003246 corticosteroid Substances 0.000 claims description 38
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 30
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 27
- 239000003961 penetration enhancing agent Substances 0.000 claims description 25
- LVTYICIALWPMFW-UHFFFAOYSA-N diisopropanolamine Chemical compound CC(O)CNCC(C)O LVTYICIALWPMFW-UHFFFAOYSA-N 0.000 claims description 18
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 18
- 229940075507 glyceryl monostearate Drugs 0.000 claims description 17
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 claims description 17
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims description 15
- MEJYDZQQVZJMPP-ULAWRXDQSA-N (3s,3ar,6r,6ar)-3,6-dimethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan Chemical compound CO[C@H]1CO[C@@H]2[C@H](OC)CO[C@@H]21 MEJYDZQQVZJMPP-ULAWRXDQSA-N 0.000 claims description 14
- HBTAOSGHCXUEKI-UHFFFAOYSA-N 4-chloro-n,n-dimethyl-3-nitrobenzenesulfonamide Chemical compound CN(C)S(=O)(=O)C1=CC=C(Cl)C([N+]([O-])=O)=C1 HBTAOSGHCXUEKI-UHFFFAOYSA-N 0.000 claims description 14
- 229940031578 diisopropyl adipate Drugs 0.000 claims description 14
- 229940100460 peg-100 stearate Drugs 0.000 claims description 14
- 235000019271 petrolatum Nutrition 0.000 claims description 14
- WJOHZNCJWYWUJD-IUGZLZTKSA-N Fluocinonide Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)COC(=O)C)[C@@]2(C)C[C@@H]1O WJOHZNCJWYWUJD-IUGZLZTKSA-N 0.000 claims description 13
- 229920002125 Sokalan® Polymers 0.000 claims description 13
- 229940043276 diisopropanolamine Drugs 0.000 claims description 13
- 229960000785 fluocinonide Drugs 0.000 claims description 13
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 claims description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 10
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 claims description 10
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 10
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims description 10
- RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 claims description 9
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 claims description 9
- 239000008213 purified water Substances 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 239000003871 white petrolatum Substances 0.000 claims description 9
- ZWVMLYRJXORSEP-UHFFFAOYSA-N 1,2,6-Hexanetriol Chemical compound OCCCCC(O)CO ZWVMLYRJXORSEP-UHFFFAOYSA-N 0.000 claims description 7
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 7
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 7
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 claims description 5
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims description 5
- ILCOCZBHMDEIAI-UHFFFAOYSA-N 2-(2-octadecoxyethoxy)ethanol Chemical compound CCCCCCCCCCCCCCCCCCOCCOCCO ILCOCZBHMDEIAI-UHFFFAOYSA-N 0.000 claims description 5
- ICIDSZQHPUZUHC-UHFFFAOYSA-N 2-octadecoxyethanol Chemical compound CCCCCCCCCCCCCCCCCCOCCO ICIDSZQHPUZUHC-UHFFFAOYSA-N 0.000 claims description 5
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims description 5
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims description 5
- 102100032373 Coiled-coil domain-containing protein 85B Human genes 0.000 claims description 5
- FKUPPRZPSYCDRS-UHFFFAOYSA-N Cyclopentadecanolide Chemical compound O=C1CCCCCCCCCCCCCCO1 FKUPPRZPSYCDRS-UHFFFAOYSA-N 0.000 claims description 5
- XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 claims description 5
- 101000868814 Homo sapiens Coiled-coil domain-containing protein 85B Proteins 0.000 claims description 5
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 5
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 5
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 5
- 239000005642 Oleic acid Substances 0.000 claims description 5
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims description 5
- 239000004264 Petrolatum Substances 0.000 claims description 5
- 229920002586 Polyethylene Glycol 7000 Polymers 0.000 claims description 5
- 229920002701 Polyoxyl 40 Stearate Polymers 0.000 claims description 5
- 229920001214 Polysorbate 60 Polymers 0.000 claims description 5
- 239000003470 adrenal cortex hormone Substances 0.000 claims description 5
- 235000019445 benzyl alcohol Nutrition 0.000 claims description 5
- VEIYJWQZNGASMA-UHFFFAOYSA-N cyclohex-3-en-1-ylmethanol Chemical compound OCC1CCC=CC1 VEIYJWQZNGASMA-UHFFFAOYSA-N 0.000 claims description 5
- 229940086555 cyclomethicone Drugs 0.000 claims description 5
- 229960000935 dehydrated alcohol Drugs 0.000 claims description 5
- XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 claims description 5
- 239000003623 enhancer Substances 0.000 claims description 5
- 229960001347 fluocinolone acetonide Drugs 0.000 claims description 5
- FEBLZLNTKCEFIT-VSXGLTOVSA-N fluocinolone acetonide Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O FEBLZLNTKCEFIT-VSXGLTOVSA-N 0.000 claims description 5
- 229940075529 glyceryl stearate Drugs 0.000 claims description 5
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 5
- 229940071826 hydroxyethyl cellulose Drugs 0.000 claims description 5
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 5
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 5
- 229940071676 hydroxypropylcellulose Drugs 0.000 claims description 5
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims description 5
- 229940074928 isopropyl myristate Drugs 0.000 claims description 5
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims description 5
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims description 5
- 229960002216 methylparaben Drugs 0.000 claims description 5
- 239000002480 mineral oil Substances 0.000 claims description 5
- 235000010446 mineral oil Nutrition 0.000 claims description 5
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 5
- 229940055577 oleyl alcohol Drugs 0.000 claims description 5
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 claims description 5
- 230000035515 penetration Effects 0.000 claims description 5
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 claims description 5
- 229940066842 petrolatum Drugs 0.000 claims description 5
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 claims description 5
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 claims description 5
- 229940113124 polysorbate 60 Drugs 0.000 claims description 5
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims description 5
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 claims description 5
- RUOJZAUFBMNUDX-UHFFFAOYSA-N propylene carbonate Chemical compound CC1COC(=O)O1 RUOJZAUFBMNUDX-UHFFFAOYSA-N 0.000 claims description 5
- 229960003415 propylparaben Drugs 0.000 claims description 5
- 239000001587 sorbitan monostearate Substances 0.000 claims description 5
- 235000011076 sorbitan monostearate Nutrition 0.000 claims description 5
- 229940035048 sorbitan monostearate Drugs 0.000 claims description 5
- 229950011392 sorbitan stearate Drugs 0.000 claims description 5
- 229940098760 steareth-2 Drugs 0.000 claims description 5
- 229940100458 steareth-21 Drugs 0.000 claims description 5
- PHYFQTYBJUILEZ-IUPFWZBJSA-N triolein Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC PHYFQTYBJUILEZ-IUPFWZBJSA-N 0.000 claims description 5
- 229940045860 white wax Drugs 0.000 claims description 5
- 229960001334 corticosteroids Drugs 0.000 claims description 3
- 230000002708 enhancing effect Effects 0.000 claims description 2
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/037,360 US6765001B2 (en) | 2001-12-21 | 2001-12-21 | Compositions and methods for enhancing corticosteroid delivery |
| PCT/US2002/039882 WO2003055445A2 (en) | 2001-12-21 | 2002-12-12 | Compositions and methods for enhancing corticosteriod delivery |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010172249A Division JP2010280689A (ja) | 2001-12-21 | 2010-07-30 | 副腎皮質ステロイド送達を増進するための組成物および方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005524614A JP2005524614A (ja) | 2005-08-18 |
| JP2005524614A5 true JP2005524614A5 (https=) | 2006-01-26 |
Family
ID=21893928
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003556023A Withdrawn JP2005524614A (ja) | 2001-12-21 | 2002-12-12 | 副腎皮質ステロイド送達を増進するための組成物および方法 |
| JP2010172249A Pending JP2010280689A (ja) | 2001-12-21 | 2010-07-30 | 副腎皮質ステロイド送達を増進するための組成物および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010172249A Pending JP2010280689A (ja) | 2001-12-21 | 2010-07-30 | 副腎皮質ステロイド送達を増進するための組成物および方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (8) | US6765001B2 (https=) |
| EP (2) | EP1465636A4 (https=) |
| JP (2) | JP2005524614A (https=) |
| CN (1) | CN1617730A (https=) |
| BR (1) | BR0215254A (https=) |
| CA (1) | CA2471041C (https=) |
| IL (1) | IL162581A0 (https=) |
| MX (1) | MXPA04006014A (https=) |
| WO (1) | WO2003055445A2 (https=) |
Families Citing this family (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6630152B2 (en) * | 1999-04-07 | 2003-10-07 | Shen Wei (Usa), Inc. | Aloe vera glove and manufacturing method |
| US8512718B2 (en) | 2000-07-03 | 2013-08-20 | Foamix Ltd. | Pharmaceutical composition for topical application |
| US6765001B2 (en) * | 2001-12-21 | 2004-07-20 | Medicis Pharmaceutical Corporation | Compositions and methods for enhancing corticosteroid delivery |
| IL152486A0 (en) | 2002-10-25 | 2003-05-29 | Meir Eini | Alcohol-free cosmetic and pharmaceutical foam carrier |
| US8900554B2 (en) | 2002-10-25 | 2014-12-02 | Foamix Pharmaceuticals Ltd. | Foamable composition and uses thereof |
| US20080138296A1 (en) | 2002-10-25 | 2008-06-12 | Foamix Ltd. | Foam prepared from nanoemulsions and uses |
| US9668972B2 (en) | 2002-10-25 | 2017-06-06 | Foamix Pharmaceuticals Ltd. | Nonsteroidal immunomodulating kit and composition and uses thereof |
| US9211259B2 (en) | 2002-11-29 | 2015-12-15 | Foamix Pharmaceuticals Ltd. | Antibiotic kit and composition and uses thereof |
| ES2532906T5 (es) | 2002-10-25 | 2022-03-23 | Foamix Pharmaceuticals Ltd | Espuma cosmética y farmacéutica |
| US7820145B2 (en) | 2003-08-04 | 2010-10-26 | Foamix Ltd. | Oleaginous pharmaceutical and cosmetic foam |
| US8486376B2 (en) | 2002-10-25 | 2013-07-16 | Foamix Ltd. | Moisturizing foam containing lanolin |
| US8119150B2 (en) * | 2002-10-25 | 2012-02-21 | Foamix Ltd. | Non-flammable insecticide composition and uses thereof |
| US7704518B2 (en) | 2003-08-04 | 2010-04-27 | Foamix, Ltd. | Foamable vehicle and pharmaceutical compositions thereof |
| US7700076B2 (en) * | 2002-10-25 | 2010-04-20 | Foamix, Ltd. | Penetrating pharmaceutical foam |
| US9265725B2 (en) | 2002-10-25 | 2016-02-23 | Foamix Pharmaceuticals Ltd. | Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof |
| US10117812B2 (en) | 2002-10-25 | 2018-11-06 | Foamix Pharmaceuticals Ltd. | Foamable composition combining a polar solvent and a hydrophobic carrier |
| US8119109B2 (en) | 2002-10-25 | 2012-02-21 | Foamix Ltd. | Foamable compositions, kits and methods for hyperhidrosis |
| US7575739B2 (en) | 2003-04-28 | 2009-08-18 | Foamix Ltd. | Foamable iodine composition |
| US8795693B2 (en) | 2003-08-04 | 2014-08-05 | Foamix Ltd. | Compositions with modulating agents |
| US8486374B2 (en) | 2003-08-04 | 2013-07-16 | Foamix Ltd. | Hydrophilic, non-aqueous pharmaceutical carriers and compositions and uses |
| US20050238672A1 (en) * | 2004-04-27 | 2005-10-27 | Nimni Marcel E | Antifungal drug delivery |
| US7897587B2 (en) | 2004-09-03 | 2011-03-01 | Nycomed Us Inc. | Topical dermatological formulations and use thereof |
| AU2006298442A1 (en) | 2005-05-09 | 2007-04-12 | Foamix Ltd. | Saccharide foamable compositions |
| CA2607608A1 (en) * | 2005-05-10 | 2006-11-16 | Alcon, Inc. | Suspension formulations of nepafenac and other ophthalmic drugs for topical treatment of ophthalmic disorders |
| PL1906916T3 (pl) * | 2005-05-10 | 2009-02-27 | Alcon Inc | Zawiesina do oczu obejmująca lek okulistyczny, poloksaminę i glikolowy środek regulujący toniczność, zastosowanie wymienionej kompozycji do wytwarzania leku do leczenia zaburzeń wzroku |
| WO2007046315A1 (ja) * | 2005-10-17 | 2007-04-26 | Nisshin Kyorin Pharmaceutical Co., Ltd. | 皮膚外用剤 |
| US9486408B2 (en) | 2005-12-01 | 2016-11-08 | University Of Massachusetts Lowell | Botulinum nanoemulsions |
| US20100130460A1 (en) * | 2005-12-09 | 2010-05-27 | Nycomed Us Inc. | Topical glucocorticosteroid formulations |
| US20070179121A1 (en) * | 2006-02-02 | 2007-08-02 | Plott R T | Method of treating pediatric patients with corticosteroids |
| EP1998742A2 (en) * | 2006-03-08 | 2008-12-10 | Nuviance, INC. | Transdermal drug delivery compositions and topical compositions for application on the skin |
| FR2898499B1 (fr) * | 2006-03-15 | 2008-11-28 | Galderma Sa | Nouvelles compositions topiques sous forme d'emulsion h/e comprenant un glycol pro-penetrant |
| US8413435B2 (en) * | 2006-06-13 | 2013-04-09 | Wescast Industries, Inc. | Exhaust manifolds including heat shield assemblies |
| PT2494959E (pt) * | 2006-07-05 | 2015-02-20 | Foamix Pharmaceuticals Ltd | Veículo formador de espuma de ácido dicarboxílico e suas composições farmacêuticas |
| GB2443161B (en) * | 2006-10-28 | 2011-03-23 | Nupharm Lab Ltd | Clobetasol spray |
| GB2443162B (en) * | 2006-10-28 | 2011-02-09 | Nupharm Lab Ltd | Betamethasone spray |
| US20080260655A1 (en) | 2006-11-14 | 2008-10-23 | Dov Tamarkin | Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses |
| WO2008070538A2 (en) | 2006-12-01 | 2008-06-12 | Anterios, Inc. | Micellar nanoparticles comprising botulinum toxin |
| US20080152592A1 (en) * | 2006-12-21 | 2008-06-26 | Bayer Healthcare Llc | Method of therapeutic drug monitoring |
| JP2010514789A (ja) * | 2006-12-27 | 2010-05-06 | アベール ファーマシューティカルズ インコーポレイテッド | 副腎皮質ステロイド投与のための経皮的方法及びパッチ |
| WO2008115224A2 (en) * | 2007-03-20 | 2008-09-25 | Bayer Healthcare Llc | Method of analyzing an analyte |
| US8636982B2 (en) | 2007-08-07 | 2014-01-28 | Foamix Ltd. | Wax foamable vehicle and pharmaceutical compositions thereof |
| WO2009069006A2 (en) | 2007-11-30 | 2009-06-04 | Foamix Ltd. | Foam containing benzoyl peroxide |
| WO2009072007A2 (en) | 2007-12-07 | 2009-06-11 | Foamix Ltd. | Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof |
| US8518376B2 (en) | 2007-12-07 | 2013-08-27 | Foamix Ltd. | Oil-based foamable carriers and formulations |
| CA2712120A1 (en) | 2008-01-14 | 2009-07-23 | Foamix Ltd. | Poloxamer foamable pharmaceutical compositions with active agents and/or therapeutic cells and uses |
| US20090298803A1 (en) * | 2008-05-28 | 2009-12-03 | Glenmark Generics Ltd. | Pharmaceutical composition comprising fluocinonide |
| MX379265B (es) * | 2008-06-26 | 2025-03-11 | Anterios Inc | Aplicacion dérmica de toxina botulínica en nanoemulsiones para usarse en el tratamiento de trastornos de la piel. |
| TW201035054A (en) * | 2009-02-27 | 2010-10-01 | Lundbeck & Co As H | Methods of administering (4aR, 10aR)-1-n-propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[g]quinoline-6,7-diol and pharmaceutical compositions thereof |
| US20120087872A1 (en) | 2009-04-28 | 2012-04-12 | Foamix Ltd. | Foamable Vehicles and Pharmaceutical Compositions Comprising Aprotic Polar Solvents and Uses Thereof |
| AR077490A1 (es) * | 2009-07-21 | 2011-08-31 | Novartis Ag | Composiciones farmaceuticas topicas para el tratamiento de una condicion hiperproliferativa de la piel |
| CA2769625C (en) | 2009-07-29 | 2017-04-11 | Foamix Ltd. | Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses |
| WO2011013008A2 (en) | 2009-07-29 | 2011-02-03 | Foamix Ltd. | Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses |
| ES2637447T3 (es) | 2009-08-31 | 2017-10-13 | Dr. Reddy's Laboratories Ltd. | Formulaciones tópicas que contienen un esteroide |
| US10029013B2 (en) | 2009-10-02 | 2018-07-24 | Foamix Pharmaceuticals Ltd. | Surfactant-free, water-free formable composition and breakable foams and their uses |
| US9849142B2 (en) | 2009-10-02 | 2017-12-26 | Foamix Pharmaceuticals Ltd. | Methods for accelerated return of skin integrity and for the treatment of impetigo |
| US8968755B2 (en) | 2010-10-23 | 2015-03-03 | Joel Schlessinger | Topical base and active agent-containing compositions, and methods for improving and treating skin |
| US8685381B2 (en) | 2010-10-23 | 2014-04-01 | Joel Schlessinger | Topical base and active agent-containing compositions, and methods for improving and treating skin |
| US11957753B2 (en) | 2010-11-22 | 2024-04-16 | Bausch Health Ireland Limited | Pharmaceutical formulations containing corticosteroids for topical administration |
| US8809307B2 (en) * | 2010-11-22 | 2014-08-19 | Dow Pharmaceutical Sciences, Inc. | Pharmaceutical formulations containing corticosteroids for topical administration |
| CN103533926A (zh) * | 2011-01-24 | 2014-01-22 | 安特里奥公司 | 空纳米颗粒组合物及其用于治疗皮肤病学病症的用途 |
| GB201110632D0 (en) * | 2011-06-22 | 2011-08-03 | King S College London | Drug delivery formulations |
| WO2013029009A1 (en) | 2011-08-24 | 2013-02-28 | Novan, Inc. | Tunable nitric oxide-releasing macromolecules having multiple nitric oxide donor structures |
| JP5820206B2 (ja) * | 2011-09-13 | 2015-11-24 | 日東電工株式会社 | 経皮吸収促進用組成物および貼付製剤 |
| US8962028B2 (en) | 2012-10-18 | 2015-02-24 | MiCal Pharmaceuticals LLC—H Series, a Series of MiCal Pharmaceuticals LLC, a Multi-Division Limited Liability Company | Topical steroid composition and method |
| US10111956B2 (en) | 2013-06-03 | 2018-10-30 | Tolmar, Inc. | Corticosteroid compositions |
| KR102321169B1 (ko) | 2013-08-08 | 2021-11-02 | 노반, 인크. | 국소 조성물 및 그의 사용 방법 |
| CN105682635A (zh) * | 2013-08-09 | 2016-06-15 | 得凯莫斯公司弗罗里达有限公司 | 含有环状二酯的护肤组合物及其方法 |
| US20160184431A1 (en) | 2014-03-11 | 2016-06-30 | Promius Pharma Llc | Topical compositions comprising a corticosteroid |
| US10322082B2 (en) | 2014-07-11 | 2019-06-18 | Novan, Inc. | Topical antiviral compositions and methods of using the same |
| CN108282998B (zh) | 2015-06-18 | 2021-07-06 | 凡利亚药品北美公司 | 用于治疗银屑病的包含皮质类固醇和类视黄醇的局部组合物 |
| US11446236B2 (en) | 2015-08-05 | 2022-09-20 | Cmpd Licensing, Llc | Topical antimicrobial compositions and methods of formulating the same |
| US11684567B2 (en) | 2015-08-05 | 2023-06-27 | Cmpd Licensing, Llc | Compositions and methods for treating an infection |
| US11793783B2 (en) | 2015-08-05 | 2023-10-24 | Cmpd Licensing, Llc | Compositions and methods for treating an infection |
| EP3143986A1 (en) | 2015-09-21 | 2017-03-22 | Zimmer MedizinSysteme GmbH | Hydrophilic gel for topical delivery of 5-aminolevulinic acid and production thereof |
| MX377365B (es) | 2016-09-08 | 2025-03-10 | Journey Medical Corp | Composiciones y métodos para tratar rosácea y acné. |
| AU2017360346B2 (en) | 2016-11-21 | 2023-11-23 | Eirion Therapeutics, Inc. | Transdermal delivery of large agents |
| US11311482B2 (en) | 2017-05-12 | 2022-04-26 | Bausch Health Us, Llc | Topical compositions and methods for treating skin diseases |
| CN112566623A (zh) * | 2018-08-16 | 2021-03-26 | 瑞迪博士实验室有限公司 | 局部用油质组合物 |
| EP3930808A4 (en) * | 2019-02-27 | 2022-12-14 | Oticara, Inc. | METHODS OF TREATMENT OF NASAL, SINONASAL AND NASOPHARYNGEAL TISSUE INFECTION AND/OR INFLAMMATION |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3592930A (en) * | 1968-07-19 | 1971-07-13 | Syntex Corp | Moisture-deterioratable topical medicaments,particularly anti-inflammatory steroids,in a substantially non-aqueous fatty alcohol-propylene glycol vehicle |
| US4017615A (en) | 1970-10-29 | 1977-04-12 | Syntex Corporation | Propylene carbonate ointment vehicle |
| US3934013A (en) * | 1975-02-21 | 1976-01-20 | Syntex (U.S.A.) Inc. | Pharmaceutical composition |
| DE2964471D1 (en) * | 1979-06-08 | 1983-02-17 | Toko Yakuhin Kogyo Kk | Creamy preparation containing steroid and process for the preparation thereof |
| JPS58225009A (ja) | 1982-06-23 | 1983-12-27 | Shionogi & Co Ltd | コルチコステロイド外用製剤 |
| JPS6136219A (ja) * | 1984-07-27 | 1986-02-20 | Shiseido Co Ltd | 皮膚外用剤 |
| US4879119A (en) * | 1984-02-21 | 1989-11-07 | Yamanouchi Pharmaceutical Co., Ltd. | Patch |
| US4831023A (en) | 1986-06-27 | 1989-05-16 | Thames Pharmacal Co., Inc. | Water washable vehicles for topical use |
| JPH0676328B2 (ja) * | 1987-04-14 | 1994-09-28 | 株式会社大塚製薬工場 | ステロイドクリ−ム製剤 |
| US4855294A (en) * | 1988-09-06 | 1989-08-08 | Theratech, Inc. | Method for reducing skin irritation associated with drug/penetration enhancer compositions |
| WO1991008733A1 (en) * | 1989-12-20 | 1991-06-27 | Schering Corporation | Stable cream and lotion bases for lipophilic drug compositions |
| WO1994012146A1 (en) * | 1992-11-23 | 1994-06-09 | Estee Lauder, Inc. | Self-tanning cosmetic compositions and methods of using the same |
| US6300326B1 (en) | 1994-11-02 | 2001-10-09 | Michael R. Dobbs | Composition and method for control and treatment of cutaneous inflammation |
| KR970064620A (ko) * | 1996-03-05 | 1997-10-13 | 임성기 | 사이클로스포린-함유 외용약제 조성물 |
| JPH10204001A (ja) * | 1996-11-15 | 1998-08-04 | Kao Corp | 経皮吸収促進剤 |
| US6075056A (en) | 1997-10-03 | 2000-06-13 | Penederm, Inc. | Antifungal/steroid topical compositions |
| JPH11158060A (ja) * | 1997-11-18 | 1999-06-15 | Bristol Myers Squibb Co | 長期間貯蔵される組成物中の医薬及び／又は透過増強剤が不安定なときに透過増強剤により医薬の皮膚透過を増強させる方法及び組成物 |
| US6066281A (en) * | 1998-06-16 | 2000-05-23 | Velcro Industries B.V. | Fastener products and their production |
| WO2000040250A1 (fr) * | 1999-01-06 | 2000-07-13 | Taisho Pharmaceutical Co.,Ltd. | Lotion a base d'amelometasone |
| US6656928B1 (en) * | 1999-09-02 | 2003-12-02 | Mccadden Michael E. | Composition for the topical treatment of rashes, dermatoses and lesions |
| US20020013294A1 (en) * | 2000-03-31 | 2002-01-31 | Delong Mitchell Anthony | Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives |
| US6765001B2 (en) * | 2001-12-21 | 2004-07-20 | Medicis Pharmaceutical Corporation | Compositions and methods for enhancing corticosteroid delivery |
| US20050192261A1 (en) * | 2003-09-15 | 2005-09-01 | Jost-Price Edward R. | Methods and reagents for the treatment of immunoinflammatory disorders |
-
2001
- 2001-12-21 US US10/037,360 patent/US6765001B2/en not_active Expired - Lifetime
-
2002
- 2002-12-12 JP JP2003556023A patent/JP2005524614A/ja not_active Withdrawn
- 2002-12-12 EP EP02795857A patent/EP1465636A4/en not_active Ceased
- 2002-12-12 WO PCT/US2002/039882 patent/WO2003055445A2/en not_active Ceased
- 2002-12-12 CA CA2471041A patent/CA2471041C/en not_active Expired - Lifetime
- 2002-12-12 EP EP20100184291 patent/EP2363150A1/en not_active Withdrawn
- 2002-12-12 MX MXPA04006014A patent/MXPA04006014A/es active IP Right Grant
- 2002-12-12 CN CNA028277236A patent/CN1617730A/zh active Pending
- 2002-12-12 BR BR0215254-1A patent/BR0215254A/pt not_active IP Right Cessation
- 2002-12-12 IL IL16258102A patent/IL162581A0/xx unknown
-
2003
- 2003-04-04 US US10/407,354 patent/US7217422B2/en not_active Expired - Lifetime
- 2003-04-04 US US10/407,380 patent/US7220424B2/en not_active Expired - Lifetime
-
2004
- 2004-04-16 US US10/825,977 patent/US20040198709A1/en not_active Abandoned
-
2007
- 2007-01-24 US US11/657,880 patent/US7771733B2/en not_active Expired - Fee Related
- 2007-01-24 US US11/657,893 patent/US7794738B2/en not_active Expired - Fee Related
-
2009
- 2009-01-29 US US12/322,346 patent/US8232264B2/en not_active Expired - Fee Related
-
2010
- 2010-07-30 JP JP2010172249A patent/JP2010280689A/ja active Pending
-
2012
- 2012-07-30 US US13/561,277 patent/US20120289490A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2005524614A5 (https=) | ||
| CA2471041A1 (en) | Compositions and methods for enhancing corticosteriod delivery | |
| CY1120513T1 (el) | Υψηλης συμπυκνωσης συνθεση μινοξιδιλης | |
| US5807568A (en) | Enhanced delivery of topical compositions containing flurbiprofen | |
| AU725283B2 (en) | Bioadhesive pharmaceutical composition for the controlled release of active principles | |
| JP2022058765A5 (https=) | ||
| JP2003512427A5 (https=) | ||
| RU2004118487A (ru) | Тонкоизмельченный пленкообразующий порошок, содержащие его композиции, способы его получения и применения | |
| JP2005314323A (ja) | 育毛剤組成物 | |
| JP2007536312A (ja) | 抗コリン作用薬のための透過性増強組成物 | |
| JP5290582B2 (ja) | 爪用医薬組成物 | |
| CA2391076A1 (en) | Solutions containing epinastin | |
| MY101536A (en) | Anti-inflammatory and analgesic tape for external use | |
| JPH10152433A (ja) | 被膜形成性抗真菌剤組成物 | |
| EP3527205B1 (en) | Water-based adhesive patch | |
| WO2005107732A1 (de) | Topische zubereitung enthaltend ambroxol | |
| JP2010189440A (ja) | 爪用貼付剤 | |
| JP2005187328A (ja) | イブプロフェン含有解熱鎮痛組成物、及び感冒薬 | |
| NO20021476L (no) | Farmasöytisk b¶rerformulering | |
| CA2382548A1 (en) | Treatment of migraine by the administration of alpha-lipoic acid or derivatives thereof | |
| JPH0256328B2 (https=) | ||
| JP2005535635A5 (https=) | ||
| JP2008534644A5 (ja) | ２型糖尿病を治療または予防する組成物 | |
| JP2548686B2 (ja) | 外用薬剤組成物 | |
| JPH0231052B2 (https=) |