JP2005524519A - 小さな結晶の調製 - Google Patents
小さな結晶の調製 Download PDFInfo
- Publication number
- JP2005524519A JP2005524519A JP2004501028A JP2004501028A JP2005524519A JP 2005524519 A JP2005524519 A JP 2005524519A JP 2004501028 A JP2004501028 A JP 2004501028A JP 2004501028 A JP2004501028 A JP 2004501028A JP 2005524519 A JP2005524519 A JP 2005524519A
- Authority
- JP
- Japan
- Prior art keywords
- suspension
- crystals
- crystal
- spray drying
- liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000013078 crystal Substances 0.000 title claims abstract description 121
- 239000000725 suspension Substances 0.000 claims abstract description 47
- 239000007788 liquid Substances 0.000 claims abstract description 40
- 238000000034 method Methods 0.000 claims abstract description 39
- 238000002156 mixing Methods 0.000 claims abstract description 34
- 238000005406 washing Methods 0.000 claims description 20
- 239000000243 solution Substances 0.000 claims description 15
- 238000001694 spray drying Methods 0.000 claims description 15
- 239000012296 anti-solvent Substances 0.000 claims description 11
- 239000012530 fluid Substances 0.000 claims description 11
- 238000002425 crystallisation Methods 0.000 claims description 10
- 230000008025 crystallization Effects 0.000 claims description 9
- 239000012047 saturated solution Substances 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 238000000527 sonication Methods 0.000 claims description 4
- 238000009295 crossflow filtration Methods 0.000 claims description 3
- 239000012528 membrane Substances 0.000 claims description 3
- 238000000108 ultra-filtration Methods 0.000 claims description 3
- 238000007865 diluting Methods 0.000 claims description 2
- 239000002904 solvent Substances 0.000 abstract description 20
- 238000004519 manufacturing process Methods 0.000 abstract description 17
- 239000007921 spray Substances 0.000 abstract description 10
- 239000000126 substance Substances 0.000 abstract description 6
- 238000002604 ultrasonography Methods 0.000 abstract description 6
- 230000002776 aggregation Effects 0.000 abstract description 5
- 239000004615 ingredient Substances 0.000 abstract description 3
- 238000004220 aggregation Methods 0.000 abstract description 2
- 239000006199 nebulizer Substances 0.000 abstract 1
- 239000002245 particle Substances 0.000 description 16
- 238000009826 distribution Methods 0.000 description 9
- 239000000463 material Substances 0.000 description 9
- 238000001035 drying Methods 0.000 description 8
- 239000000047 product Substances 0.000 description 7
- 230000015572 biosynthetic process Effects 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 238000010899 nucleation Methods 0.000 description 4
- 230000006911 nucleation Effects 0.000 description 4
- 238000001556 precipitation Methods 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 238000005054 agglomeration Methods 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 238000011109 contamination Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 239000000523 sample Substances 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 2
- 230000000903 blocking effect Effects 0.000 description 2
- DKPFZGUDAPQIHT-UHFFFAOYSA-N butyl acetate Chemical compound CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 description 2
- 239000006285 cell suspension Substances 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 description 2
- 235000021310 complex sugar Nutrition 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 239000007791 liquid phase Substances 0.000 description 2
- 235000010987 pectin Nutrition 0.000 description 2
- 229920001277 pectin Polymers 0.000 description 2
- 239000001814 pectin Substances 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- SCVFZCLFOSHCOH-UHFFFAOYSA-M potassium acetate Chemical compound [K+].CC([O-])=O SCVFZCLFOSHCOH-UHFFFAOYSA-M 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 230000005070 ripening Effects 0.000 description 2
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- OPEGYZAATHKDEM-HCWXCVPCSA-N (2r,4s)-2-[(r)-carboxy(formamido)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid Chemical compound CC1(C)S[C@H]([C@H](NC=O)C(O)=O)N[C@H]1C(O)=O OPEGYZAATHKDEM-HCWXCVPCSA-N 0.000 description 1
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 description 1
- 229930186147 Cephalosporin Natural products 0.000 description 1
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 239000003905 agrochemical Substances 0.000 description 1
- 239000013566 allergen Substances 0.000 description 1
- 150000001414 amino alcohols Chemical class 0.000 description 1
- 229940035676 analgesics Drugs 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000001387 anti-histamine Effects 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 229940125715 antihistaminic agent Drugs 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000005815 base catalysis Methods 0.000 description 1
- 238000010923 batch production Methods 0.000 description 1
- IYNDLOXRXUOGIU-LQDWTQKMSA-M benzylpenicillin potassium Chemical compound [K+].N([C@H]1[C@H]2SC([C@@H](N2C1=O)C([O-])=O)(C)C)C(=O)CC1=CC=CC=C1 IYNDLOXRXUOGIU-LQDWTQKMSA-M 0.000 description 1
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 description 1
- 229940124630 bronchodilator Drugs 0.000 description 1
- 239000000168 bronchodilator agent Substances 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 229940124587 cephalosporin Drugs 0.000 description 1
- 150000001780 cephalosporins Chemical class 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000003749 cleanliness Effects 0.000 description 1
- 229960004126 codeine Drugs 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 239000000112 cooling gas Substances 0.000 description 1
- 229960000265 cromoglicic acid Drugs 0.000 description 1
- IMZMKUWMOSJXDT-UHFFFAOYSA-N cromoglycic acid Chemical compound O1C(C(O)=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=CC=CC2=C1C(=O)C=C(C(O)=O)O2 IMZMKUWMOSJXDT-UHFFFAOYSA-N 0.000 description 1
- -1 d-maltose Chemical class 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000002036 drum drying Methods 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 229960002442 glucosamine Drugs 0.000 description 1
- OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000000643 oven drying Methods 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 235000011056 potassium acetate Nutrition 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 235000019192 riboflavin Nutrition 0.000 description 1
- 239000002151 riboflavin Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
- 150000003456 sulfonamides Chemical class 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229940093257 valacyclovir Drugs 0.000 description 1
Images
Classifications
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B3/00—Drying solid materials or objects by processes involving the application of heat
- F26B3/02—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air
- F26B3/10—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air the gas or vapour carrying the materials or objects to be dried with it
- F26B3/12—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air the gas or vapour carrying the materials or objects to be dried with it in the form of a spray, i.e. sprayed or dispersed emulsions or suspensions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D1/00—Evaporating
- B01D1/16—Evaporating by spraying
- B01D1/18—Evaporating by spraying to obtain dry solids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/0018—Evaporation of components of the mixture to be separated
- B01D9/0027—Evaporation of components of the mixture to be separated by means of conveying fluid, e.g. spray-crystallisation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
- B01D9/0054—Use of anti-solvent
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/0059—General arrangements of crystallisation plant, e.g. flow sheets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/0081—Use of vibrations, e.g. ultrasound
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S117/00—Single-crystal, oriented-crystal, and epitaxy growth processes; non-coating apparatus therefor
- Y10S117/901—Levitation, reduced gravity, microgravity, space
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Crystallography & Structural Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Drying Of Solid Materials (AREA)
- Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/GB2002/002006 WO2002089942A1 (en) | 2001-05-05 | 2002-05-02 | Formation of small crystals |
| GBGB0219815.8A GB0219815D0 (en) | 2002-08-24 | 2002-08-24 | Preparation of small crystals |
| PCT/GB2003/001540 WO2003092851A1 (en) | 2002-05-02 | 2003-04-08 | Preparation of small crystals |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005524519A true JP2005524519A (ja) | 2005-08-18 |
| JP2005524519A5 JP2005524519A5 (https=) | 2009-04-16 |
Family
ID=9942964
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004501028A Pending JP2005524519A (ja) | 2002-05-02 | 2003-04-08 | 小さな結晶の調製 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7326294B2 (https=) |
| EP (1) | EP1499410B1 (https=) |
| JP (1) | JP2005524519A (https=) |
| AT (1) | ATE421900T1 (https=) |
| AU (1) | AU2003224261A1 (https=) |
| DE (1) | DE60326037D1 (https=) |
| DK (1) | DK1499410T3 (https=) |
| ES (1) | ES2321919T3 (https=) |
| GB (1) | GB0219815D0 (https=) |
| PT (1) | PT1499410E (https=) |
| SI (1) | SI1499410T1 (https=) |
| WO (1) | WO2003092851A1 (https=) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005177746A (ja) * | 2003-11-28 | 2005-07-07 | Mitsubishi Chemicals Corp | 有機化合物微粒子の製造方法 |
| JP2006519780A (ja) * | 2003-02-21 | 2006-08-31 | ザ ユニヴァーシティ オブ バース | 粒子の製造プロセス |
| JP2006239648A (ja) * | 2005-03-07 | 2006-09-14 | Ishikawajima Harima Heavy Ind Co Ltd | 脱リン装置 |
| JP2014511265A (ja) * | 2011-02-16 | 2014-05-15 | オークウッド ラボラトリーズ，エル．エル．シー． | 液体サイクロンを使用する微小球の製造 |
| JP2014511867A (ja) * | 2011-04-18 | 2014-05-19 | 合肥貝霓医薬科技有限公司 | ジヒドロピリジン系カルシウムチャネルブロッカーの精製、及びそのナノ粒子の調製方法 |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1878602A (zh) * | 2003-11-28 | 2006-12-13 | 三菱化学株式会社 | 有机化合物微粒的制造方法 |
| GB0415237D0 (en) * | 2004-07-07 | 2004-08-11 | Accentus Plc | Formation of sugar coatings |
| EP1782797A1 (en) * | 2005-11-02 | 2007-05-09 | Pharmatex Italia Srl | Process for the preparation of sterile powdered pharmaceutical compounds. |
| WO2008035962A1 (en) * | 2006-09-19 | 2008-03-27 | Fujifilm Manufacturing Europe B.V. | Process and device for the precipitation of an organic compound |
| EP2063970A1 (en) * | 2006-09-19 | 2009-06-03 | FUJIFILM Manufacturing Europe B.V. | Preparation of fine particles |
| CN101534952B (zh) * | 2006-11-02 | 2012-10-31 | 欧姆瑞克斯生物医药有限公司 | 微粉化方法 |
| GB0705159D0 (en) | 2007-03-19 | 2007-04-25 | Prosonix Ltd | Process for making crystals |
| GB0714223D0 (en) * | 2007-07-20 | 2007-08-29 | Fujifilm Mfg Europe Bv | Preparation of fine particles |
| US8771524B2 (en) * | 2008-02-08 | 2014-07-08 | Purac Biochem B.V. | Vortex mixer and method of obtaining a supersaturated solution or slurry |
| CA2729644C (en) * | 2008-07-18 | 2018-05-29 | Prosonix Limited | Process for improving crystallinity |
| GB0900080D0 (en) | 2009-01-06 | 2009-02-11 | Prosonix Ltd | An apparatus and process for producing crystals |
| US20130037977A1 (en) * | 2010-04-08 | 2013-02-14 | Paul A. Burke | Preparation of Lipid Nanoparticles |
| DE102010017490A1 (de) * | 2010-06-21 | 2011-12-22 | WME Gesellschaft für windkraftbetriebene Meerwasserentsalzung mbH | Verfahren zur Aufbereitung eines salzhaltigen Rohwassers zur Herstellung eines Prozesswassers, damit hergestelltes Prozesswasser und Vorrichtung zur Durchführung des Verfahrens |
| EP2500072A1 (en) | 2011-03-15 | 2012-09-19 | LEK Pharmaceuticals d.d. | A novel process of residual solvent removal |
| US9855538B2 (en) | 2013-03-08 | 2018-01-02 | The Board Of Trustees Of The University Of Illinois | Ultrasonic method and apparatus for producing particles having a controlled size distribution |
| CN115160090B (zh) * | 2022-07-06 | 2023-05-12 | 西安近代化学研究所 | 一种基于微流控技术的hmx超细化制备方法及制备系统 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2396689A (en) * | 1942-12-10 | 1946-03-19 | American Cyanamid Co | Spray crystallizing apparatus |
| BE572854A (https=) * | 1956-07-06 | |||
| US4489503A (en) * | 1980-11-28 | 1984-12-25 | Olin Corporation | Process for drying wet particles of available halogen compounds |
| JP2789751B2 (ja) | 1989-12-27 | 1998-08-20 | 住友化学工業株式会社 | ベルヌーイ法単結晶用原料アルミナの製造法 |
| GB9007027D0 (en) | 1990-03-29 | 1990-05-30 | Atomic Energy Authority Uk | Precipitation apparatus and method |
| US6582728B1 (en) * | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
| GB2276567B (en) * | 1993-04-03 | 1996-11-27 | Atomic Energy Authority Uk | Processing vessel |
| IL105658A (en) * | 1993-05-11 | 1995-10-31 | Ultrasonic Dryer Ltd | Spray drying system |
| AUPO637197A0 (en) * | 1997-04-23 | 1997-05-15 | F.H. Faulding & Co. Limited | Taste-masked pharmaceutical compositions |
| GB2341120B (en) | 1998-09-04 | 2002-04-17 | Aea Technology Plc | Controlling uniformity of crystalline precipitates |
| US7521068B2 (en) | 1998-11-12 | 2009-04-21 | Elan Pharma International Ltd. | Dry powder aerosols of nanoparticulate drugs |
| GB9825054D0 (en) | 1998-11-17 | 1999-01-13 | Aea Technology Plc | Method for performing cell culture |
| GB9828721D0 (en) * | 1998-12-24 | 1999-02-17 | Glaxo Group Ltd | Novel apparatus and process |
| DE19903125B4 (de) * | 1999-01-27 | 2006-01-05 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Trocknung von Kristallen von Insulin oder Insulinanaloga |
| HUP0105445A2 (en) | 1999-02-03 | 2002-06-29 | Fraunhofer Ges Forschung | Compressed air inhaler for pulmonary application of liposomal powder aerosols and powder aerosols suitable therefor |
| US6723346B1 (en) * | 1999-04-30 | 2004-04-20 | Roche Vitamins Inc. | Process for preparing spray granules containing riboflavin |
| US6223455B1 (en) * | 1999-05-03 | 2001-05-01 | Acusphere, Inc. | Spray drying apparatus and methods of use |
| US6601776B1 (en) * | 1999-09-22 | 2003-08-05 | Microcoating Technologies, Inc. | Liquid atomization methods and devices |
| JP4257717B2 (ja) | 2000-02-14 | 2009-04-22 | 日本碍子株式会社 | 単結晶育成用の原料粉末の製造方法および単結晶の製造方法 |
| BR0209433A (pt) | 2001-05-05 | 2004-08-03 | Accentus Plc | Método para realizar cristalização, e, aparelho |
| DE10137017A1 (de) * | 2001-07-30 | 2003-02-20 | Basf Ag | Kristallisationsverfahren zur Einstellung kleiner Partikel |
| US20030106488A1 (en) * | 2001-12-10 | 2003-06-12 | Wen-Chiang Huang | Manufacturing method for semiconductor quantum particles |
-
2002
- 2002-08-24 GB GBGB0219815.8A patent/GB0219815D0/en not_active Ceased
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2003
- 2003-04-08 DK DK03720684T patent/DK1499410T3/da active
- 2003-04-08 PT PT03720684T patent/PT1499410E/pt unknown
- 2003-04-08 EP EP03720684A patent/EP1499410B1/en not_active Expired - Lifetime
- 2003-04-08 DE DE60326037T patent/DE60326037D1/de not_active Expired - Lifetime
- 2003-04-08 JP JP2004501028A patent/JP2005524519A/ja active Pending
- 2003-04-08 ES ES03720684T patent/ES2321919T3/es not_active Expired - Lifetime
- 2003-04-08 AU AU2003224261A patent/AU2003224261A1/en not_active Abandoned
- 2003-04-08 US US10/513,153 patent/US7326294B2/en not_active Expired - Fee Related
- 2003-04-08 SI SI200331558T patent/SI1499410T1/sl unknown
- 2003-04-08 AT AT03720684T patent/ATE421900T1/de active
- 2003-04-08 WO PCT/GB2003/001540 patent/WO2003092851A1/en not_active Ceased
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006519780A (ja) * | 2003-02-21 | 2006-08-31 | ザ ユニヴァーシティ オブ バース | 粒子の製造プロセス |
| JP2005177746A (ja) * | 2003-11-28 | 2005-07-07 | Mitsubishi Chemicals Corp | 有機化合物微粒子の製造方法 |
| JP2006239648A (ja) * | 2005-03-07 | 2006-09-14 | Ishikawajima Harima Heavy Ind Co Ltd | 脱リン装置 |
| JP2014511265A (ja) * | 2011-02-16 | 2014-05-15 | オークウッド ラボラトリーズ，エル．エル．シー． | 液体サイクロンを使用する微小球の製造 |
| JP2017148800A (ja) * | 2011-02-16 | 2017-08-31 | オークウッド ラボラトリーズ，エル．エル．シー． | 液体サイクロンを使用する微小球の製造 |
| JP2014511867A (ja) * | 2011-04-18 | 2014-05-19 | 合肥貝霓医薬科技有限公司 | ジヒドロピリジン系カルシウムチャネルブロッカーの精製、及びそのナノ粒子の調製方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| PT1499410E (pt) | 2009-04-08 |
| DK1499410T3 (da) | 2009-06-02 |
| DE60326037D1 (de) | 2009-03-19 |
| GB0219815D0 (en) | 2002-10-02 |
| ES2321919T3 (es) | 2009-06-15 |
| EP1499410A1 (en) | 2005-01-26 |
| EP1499410B1 (en) | 2009-01-28 |
| SI1499410T1 (sl) | 2009-06-30 |
| WO2003092851A1 (en) | 2003-11-13 |
| US7326294B2 (en) | 2008-02-05 |
| AU2003224261A1 (en) | 2003-11-17 |
| US20050155541A1 (en) | 2005-07-21 |
| ATE421900T1 (de) | 2009-02-15 |
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