JP2005523326A - プロテインキナーゼｃのペプチドインヒビター - Google Patents
プロテインキナーゼｃのペプチドインヒビター Download PDFInfo
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K7/04—Linear peptides containing only normal peptide links
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Landscapes
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Applications Claiming Priority (2)
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| US37453002P | 2002-04-22 | 2002-04-22 | |
| PCT/US2003/012541 WO2003089456A2 (en) | 2002-04-22 | 2003-04-22 | Peptide inhibitors of protein kinase c |
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| JP2009011456A Division JP2009102392A (ja) | 2002-04-22 | 2009-01-21 | プロテインキナーゼｃのペプチドインヒビター |
| JP2012128849A Division JP2012176978A (ja) | 2002-04-22 | 2012-06-06 | プロテインキナーゼｃのペプチドインヒビター |
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| JP2003586177A Pending JP2005527209A (ja) | 2002-04-22 | 2003-04-22 | 疼痛管理のためのプロテインキナーゼＣγのペプチドインヒビター |
| JP2009010402A Pending JP2009091372A (ja) | 2002-04-22 | 2009-01-20 | 疼痛管理のためのプロテインキナーゼＣγのペプチドインヒビター |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005527209A (ja) * | 2002-04-22 | 2005-09-15 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 疼痛管理のためのプロテインキナーゼＣγのペプチドインヒビター |
| JP2009508879A (ja) * | 2005-09-19 | 2009-03-05 | カイ ファーマシューティカルズ インコーポレーティッド | 血管新生のプロテインキナーゼｃペプチドモジュレーター |
| JP2010516707A (ja) * | 2007-01-19 | 2010-05-20 | カイ ファーマシューティカルズ インコーポレーティッド | ペプチド組成物の安定性および送達効率を上昇させるための修飾方法 |
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| US6933275B2 (en) * | 2002-05-01 | 2005-08-23 | The Board Of Trustees Of The Leland Stanford Junior University | Protein kinase C peptides for use in withdrawal |
| WO2004084889A1 (en) * | 2003-03-28 | 2004-10-07 | Pfizer Inc. | Use of protein kinase c inhibitor for suppressing sustained slow postsynaptic excitation (sspe) of enteric neurons |
| WO2004103266A2 (en) * | 2003-05-16 | 2004-12-02 | The Board Of Trustees Of The Leland Stanford Junior University | Protein kinase c peptides for use in withdrawal |
| WO2005032575A1 (en) * | 2003-10-02 | 2005-04-14 | The Board Of Trustees Of The Leland Stanford Junior University | Protein kinase c peptides for use in withdrawal |
| US20090123468A1 (en) | 2003-10-24 | 2009-05-14 | Gencia Corporation | Transducible polypeptides for modifying metabolism |
| AU2004297533B2 (en) | 2003-10-24 | 2010-04-29 | Gencia Corporation | Methods and compositions for delivering polynucleotides |
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| US8507277B2 (en) * | 2003-10-24 | 2013-08-13 | Gencia Corporation | Nonviral vectors for delivering polynucleotides |
| US8133733B2 (en) | 2003-10-24 | 2012-03-13 | Gencia Corporation | Nonviral vectors for delivering polynucleotides to target tissues |
| US20090208478A1 (en) * | 2003-10-24 | 2009-08-20 | Gencia Corporation | Transducible polypeptides for modifying metabolism |
| US20050187156A1 (en) * | 2003-12-11 | 2005-08-25 | Daria Mochly-Rosen | Isozyme-specific antagonists of protein kinase C |
| US7265092B2 (en) * | 2004-09-30 | 2007-09-04 | Kai Pharmaceuticals, Inc. | Pharmaceutical formulation |
| US20060148700A1 (en) * | 2004-11-10 | 2006-07-06 | Daria Mochly-Rosen | Methods and compositions for reducing injury to a transplanted organ |
| US20060160062A1 (en) * | 2005-01-14 | 2006-07-20 | Young Lindon H | Perfusion and/or preservation solution for organs |
| US8158586B2 (en) * | 2005-04-11 | 2012-04-17 | Pharmagap Inc. | Inhibitors of protein kinases and uses thereof |
| WO2007016763A1 (en) * | 2005-08-05 | 2007-02-15 | Pharmagap Inc. | Peptides targeted to protein kinase c isoforms and uses thereof |
| JP5276982B2 (ja) | 2005-08-26 | 2013-08-28 | ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティ | オキシトシンの投与による頭痛の処置のための方法 |
| WO2007112556A1 (en) * | 2006-03-30 | 2007-10-11 | Salpep Biotechnology Inc. | Suppression and treatment of neuropathic pain |
| US7741290B2 (en) * | 2006-06-01 | 2010-06-22 | The Board of Trustee of The Leland Stanford Juinior University | Method of preventing progression of hypertension-induced heart failure with PKC peptides |
| US8017583B2 (en) | 2007-01-19 | 2011-09-13 | Kai Pharmaceuticals, Inc. | Methods of use of epsilon inhibitor compounds for the attenuation of pain |
| US20090062208A1 (en) * | 2007-02-06 | 2009-03-05 | Mochly-Rosen Daria D | Methods for maintaining blood-brain barrier integrity in hypertensive subjects using a delta-PKC inhibitor |
| MX2009010757A (es) * | 2007-04-06 | 2010-02-24 | Kai Pharmaceuticals Inc | Metodos de uso de compuestos de inhibidor gamma para atenuacion del dolor. |
| WO2008154004A2 (en) * | 2007-06-07 | 2008-12-18 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of tumor metastases using protein kinase c (pkc) inhibitors |
| CA2710380A1 (en) | 2007-12-21 | 2009-07-09 | Coda Therapeutics, Inc. | Use of anti-connexin 43 poly nucleotide for the treatment of fibrotic conditions |
| US20090318351A1 (en) * | 2008-03-12 | 2009-12-24 | Kevin Grimes | Method of treating acute st-elevation myocardial infarction with a delta pkc antagonist |
| CA2719059C (en) * | 2008-03-27 | 2016-05-17 | Nestec S.A. | Methods for increasing absorption of peptides, peptidomimetics, and other gastrointestinal transport protein substrates |
| WO2010019965A1 (en) * | 2008-08-15 | 2010-02-18 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for modulating epsilon protein kinase c-mediated cytoprotection |
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| US20100311671A1 (en) * | 2009-03-25 | 2010-12-09 | Kai Pharmaceuticals | Transdermal delivery of pkc modulatory peptides through microporated skin |
| US20120208750A1 (en) | 2009-09-29 | 2012-08-16 | Joslin Diabetes Center, Inc. | Use of protein kinase c delta (pkcd) inhibitors to treat diabetes, obesity, and hepatic steatosis |
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| US8785648B1 (en) | 2010-08-10 | 2014-07-22 | The Regents Of The University Of California | PKC-epsilon inhibitors |
| US9217137B2 (en) | 2011-08-12 | 2015-12-22 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for specific regulation of pyruvate dehydrogenase kinase |
| WO2013163171A1 (en) | 2012-04-24 | 2013-10-31 | Kaufman Dan S | Method for developing natural killer cells from stem cells |
| CA2923765C (en) | 2013-09-18 | 2021-06-29 | University Of Canberra | Stem cell modulation ii |
| WO2016003450A1 (en) | 2014-07-01 | 2016-01-07 | The Regents Of The University Of California | Pkc-epsilon inhibitors |
| AU2015309686B2 (en) | 2014-08-25 | 2020-05-14 | Epiaxis Therapeutics Pty Ltd | Compositions for modulating cancer stem cells and uses therefor |
| PL3242676T3 (pl) | 2015-01-07 | 2024-07-15 | Tonix Pharma Limited | Preparaty oksytocyny zawierające magnez i sposoby ich stosowania |
| HRP20250215T1 (hr) | 2016-04-12 | 2025-06-20 | Tonix Pharma Limited | Formulacije oksitocina koje sadrže magnezij i postupci upotrebe |
| CA3087881A1 (en) | 2017-01-17 | 2018-07-26 | Michael David FORREST | Therapeutic inhibitors of the reverse mode of atp synthase |
| CA3099077A1 (en) | 2017-07-13 | 2019-01-17 | Michael David FORREST | Therapeutic modulators of the reverse mode of atp synthase |
| CN111587120A (zh) | 2017-11-08 | 2020-08-25 | 艾比克斯治疗私人有限公司 | 免疫原性组合物及其用途 |
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| US4351829A (en) | 1980-09-26 | 1982-09-28 | Farmitalia Carlo Erba Spa | Use of polypeptides as analgesic drugs |
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| US5935803A (en) | 1994-02-01 | 1999-08-10 | Terrapin Technologies, Inc. | Methods to identify immunomodulators using cognate interaction of PKC-theta |
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| US6165977A (en) | 1996-10-18 | 2000-12-26 | Board Of Trustees Of The Leland Stanford Junior University | Isozyme-specific activators of protein kinase C methods and compositions |
| US6376476B1 (en) * | 1996-12-13 | 2002-04-23 | Zymogenetics Corporation | Isoprenoid pathway inhibitors for stimulating bone growth |
| US6218113B1 (en) * | 1998-02-24 | 2001-04-17 | Incyte Genomics, Inc. | Human protein kinase C inhibitor |
| US6376467B1 (en) * | 1998-10-09 | 2002-04-23 | The Regents Of The University Of California | Use of inhibitors of protein kinase C epsilon to treat pain |
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| US6496425B1 (en) * | 2000-08-21 | 2002-12-17 | Micron Technology, Inc | Multiple bit line column redundancy |
| CA2434643C (en) * | 2001-01-18 | 2013-10-29 | The Board Of Trustees Of The Leland Stanford Junior University | Peptides for activation and inhibition of.delta.pkc |
| JP2005523326A (ja) * | 2002-04-22 | 2005-08-04 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティ | プロテインキナーゼｃのペプチドインヒビター |
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2003
- 2003-04-22 JP JP2003586176A patent/JP2005523326A/ja not_active Withdrawn
- 2003-04-22 EP EP03728494A patent/EP1501532A4/en not_active Withdrawn
- 2003-04-22 US US10/421,503 patent/US7507711B2/en not_active Expired - Fee Related
- 2003-04-22 AU AU2003234186A patent/AU2003234186B2/en not_active Ceased
- 2003-04-22 CA CA2481512A patent/CA2481512C/en not_active Expired - Fee Related
- 2003-04-22 US US10/421,548 patent/US7459424B2/en not_active Expired - Fee Related
- 2003-04-22 CA CA2482598A patent/CA2482598C/en not_active Expired - Fee Related
- 2003-04-22 JP JP2003586177A patent/JP2005527209A/ja active Pending
- 2003-04-22 WO PCT/US2003/012542 patent/WO2003089457A2/en not_active Ceased
- 2003-04-22 WO PCT/US2003/012541 patent/WO2003089456A2/en not_active Ceased
- 2003-04-22 US US10/513,003 patent/US7393835B2/en not_active Expired - Fee Related
- 2003-04-22 CA CA2785889A patent/CA2785889A1/en not_active Abandoned
- 2003-04-22 EP EP03728495A patent/EP1501533A4/en not_active Withdrawn
- 2003-04-22 EP EP10178878A patent/EP2332559A1/en not_active Withdrawn
- 2003-04-22 AU AU2003234185A patent/AU2003234185C1/en not_active Ceased
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2007
- 2007-07-16 US US11/879,414 patent/US7833984B2/en not_active Expired - Fee Related
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2008
- 2008-06-16 US US12/214,104 patent/US7939493B2/en not_active Expired - Fee Related
- 2008-08-27 US US12/229,992 patent/US20090143293A1/en not_active Abandoned
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2009
- 2009-01-20 JP JP2009010402A patent/JP2009091372A/ja active Pending
- 2009-01-21 JP JP2009011456A patent/JP2009102392A/ja active Pending
- 2009-04-22 AU AU2009201593A patent/AU2009201593B2/en not_active Ceased
- 2009-05-04 AU AU2009201760A patent/AU2009201760B2/en not_active Ceased
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2011
- 2011-05-05 US US13/101,540 patent/US8658594B2/en not_active Expired - Fee Related
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2012
- 2012-06-06 JP JP2012128849A patent/JP2012176978A/ja active Pending
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2014
- 2014-02-21 US US14/187,070 patent/US9365837B2/en not_active Expired - Fee Related
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005527209A (ja) * | 2002-04-22 | 2005-09-15 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 疼痛管理のためのプロテインキナーゼＣγのペプチドインヒビター |
| JP2009091372A (ja) * | 2002-04-22 | 2009-04-30 | Board Of Trustees Of The Leland Stanford Junior Univ | 疼痛管理のためのプロテインキナーゼＣγのペプチドインヒビター |
| US8658594B2 (en) | 2002-04-22 | 2014-02-25 | Board of Trustees of the Leland Stanford Junior Universit | Peptide inhibitors of protein kinase C |
| US9365837B2 (en) | 2002-04-22 | 2016-06-14 | The Board Of Trustees Of The Leland Stanford Junior University | Peptide inhibitors of protein kinase C |
| JP2009508879A (ja) * | 2005-09-19 | 2009-03-05 | カイ ファーマシューティカルズ インコーポレーティッド | 血管新生のプロテインキナーゼｃペプチドモジュレーター |
| JP2010516707A (ja) * | 2007-01-19 | 2010-05-20 | カイ ファーマシューティカルズ インコーポレーティッド | ペプチド組成物の安定性および送達効率を上昇させるための修飾方法 |
| JP2014224126A (ja) * | 2007-01-19 | 2014-12-04 | カイ ファーマシューティカルズ インコーポレーティッド | ペプチド組成物の安定性および送達効率を上昇させるための修飾方法 |
| JP2016147905A (ja) * | 2007-01-19 | 2016-08-18 | カイ ファーマシューティカルズ インコーポレーティッド | ペプチド組成物の安定性および送達効率を上昇させるための修飾方法 |
| JP2018111717A (ja) * | 2007-01-19 | 2018-07-19 | カイ ファーマシューティカルズ インコーポレーティッド | ペプチド組成物の安定性および送達効率を上昇させるための修飾方法 |
| JP2021098725A (ja) * | 2007-01-19 | 2021-07-01 | カイ ファーマシューティカルズ インコーポレーティッド | ペプチド組成物の安定性および送達効率を上昇させるための修飾方法 |
| JP2023078424A (ja) * | 2007-01-19 | 2023-06-06 | カイ ファーマシューティカルズ インコーポレーティッド | ペプチド組成物の安定性および送達効率を上昇させるための修飾方法 |
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