CA2482598C - Peptide inhibitors of protein kinase c - Google Patents
Peptide inhibitors of protein kinase c Download PDFInfo
- Publication number
- CA2482598C CA2482598C CA2482598A CA2482598A CA2482598C CA 2482598 C CA2482598 C CA 2482598C CA 2482598 A CA2482598 A CA 2482598A CA 2482598 A CA2482598 A CA 2482598A CA 2482598 C CA2482598 C CA 2482598C
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- Prior art keywords
- seq
- peptide
- peptides
- asp
- pkc
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2785889A CA2785889A1 (en) | 2002-04-22 | 2003-04-22 | Peptide inhibitors of protein kinase c |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37453002P | 2002-04-22 | 2002-04-22 | |
| US60/374,530 | 2002-04-22 | ||
| PCT/US2003/012541 WO2003089456A2 (en) | 2002-04-22 | 2003-04-22 | Peptide inhibitors of protein kinase c |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2785889A Division CA2785889A1 (en) | 2002-04-22 | 2003-04-22 | Peptide inhibitors of protein kinase c |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2482598A1 CA2482598A1 (en) | 2003-10-30 |
| CA2482598C true CA2482598C (en) | 2012-09-25 |
Family
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Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
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| CA2482598A Expired - Fee Related CA2482598C (en) | 2002-04-22 | 2003-04-22 | Peptide inhibitors of protein kinase c |
| CA2785889A Abandoned CA2785889A1 (en) | 2002-04-22 | 2003-04-22 | Peptide inhibitors of protein kinase c |
| CA2481512A Expired - Fee Related CA2481512C (en) | 2002-04-22 | 2003-04-22 | Peptide inhibitors of protein kinase c.gamma. for pain management |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2785889A Abandoned CA2785889A1 (en) | 2002-04-22 | 2003-04-22 | Peptide inhibitors of protein kinase c |
| CA2481512A Expired - Fee Related CA2481512C (en) | 2002-04-22 | 2003-04-22 | Peptide inhibitors of protein kinase c.gamma. for pain management |
Country Status (6)
| Country | Link |
|---|---|
| US (8) | US7459424B2 (enExample) |
| EP (3) | EP1501533A4 (enExample) |
| JP (5) | JP2005527209A (enExample) |
| AU (4) | AU2003234185C1 (enExample) |
| CA (3) | CA2482598C (enExample) |
| WO (2) | WO2003089456A2 (enExample) |
Families Citing this family (50)
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|---|---|---|---|---|
| JP2005527209A (ja) * | 2002-04-22 | 2005-09-15 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 疼痛管理のためのプロテインキナーゼＣγのペプチドインヒビター |
| US6933275B2 (en) * | 2002-05-01 | 2005-08-23 | The Board Of Trustees Of The Leland Stanford Junior University | Protein kinase C peptides for use in withdrawal |
| WO2004084889A1 (en) * | 2003-03-28 | 2004-10-07 | Pfizer Inc. | Use of protein kinase c inhibitor for suppressing sustained slow postsynaptic excitation (sspe) of enteric neurons |
| WO2004103266A2 (en) * | 2003-05-16 | 2004-12-02 | The Board Of Trustees Of The Leland Stanford Junior University | Protein kinase c peptides for use in withdrawal |
| WO2005032575A1 (en) * | 2003-10-02 | 2005-04-14 | The Board Of Trustees Of The Leland Stanford Junior University | Protein kinase c peptides for use in withdrawal |
| US8062891B2 (en) | 2003-10-24 | 2011-11-22 | Gencia Corporation | Nonviral vectors for delivering polynucleotides to plants |
| US8507277B2 (en) * | 2003-10-24 | 2013-08-13 | Gencia Corporation | Nonviral vectors for delivering polynucleotides |
| US8133733B2 (en) | 2003-10-24 | 2012-03-13 | Gencia Corporation | Nonviral vectors for delivering polynucleotides to target tissues |
| US20090208478A1 (en) * | 2003-10-24 | 2009-08-20 | Gencia Corporation | Transducible polypeptides for modifying metabolism |
| CA2543257C (en) | 2003-10-24 | 2013-12-31 | Gencia Corporation | Methods and compositions for delivering polynucleotides |
| US20090123468A1 (en) | 2003-10-24 | 2009-05-14 | Gencia Corporation | Transducible polypeptides for modifying metabolism |
| CA2549052A1 (en) * | 2003-12-11 | 2005-06-30 | The Board Of Trustees Of The Leland Stanford Junior University | Isozyme-specific antagonists of protein kinase c |
| US7265092B2 (en) | 2004-09-30 | 2007-09-04 | Kai Pharmaceuticals, Inc. | Pharmaceutical formulation |
| US20060148700A1 (en) * | 2004-11-10 | 2006-07-06 | Daria Mochly-Rosen | Methods and compositions for reducing injury to a transplanted organ |
| US20060160062A1 (en) * | 2005-01-14 | 2006-07-20 | Young Lindon H | Perfusion and/or preservation solution for organs |
| EP1877424A4 (en) * | 2005-04-11 | 2010-09-29 | Pharmagap Inc | INHIBITORS OF PROTEIN KINASES AND USES THEREOF |
| EP2298792A3 (en) | 2005-08-05 | 2011-10-19 | Pharmagap Inc. | Peptides targeted to protein kinase C isoforms and uses thereof |
| JP5276982B2 (ja) | 2005-08-26 | 2013-08-28 | ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティ | オキシトシンの投与による頭痛の処置のための方法 |
| CA2644089A1 (en) * | 2005-09-19 | 2007-03-29 | Kai Pharmaceuticals, Inc. | Protein kinase c peptide modulators of angiogenesis |
| JP2009531335A (ja) * | 2006-03-30 | 2009-09-03 | サルペップ バイオテクノロジー インコーポレイテッド | 神経障害性疼痛の抑制および治療 |
| US7741290B2 (en) * | 2006-06-01 | 2010-06-22 | The Board of Trustee of The Leland Stanford Juinior University | Method of preventing progression of hypertension-induced heart failure with PKC peptides |
| CA2989778C (en) * | 2007-01-19 | 2020-06-30 | Kai Pharmaceuticals, Inc. | Method of modifying peptide compositions |
| KR20090117878A (ko) | 2007-01-19 | 2009-11-13 | 카이 파마슈티컬즈 | 통증의 완화를 위한 엡실론 억제제 화합물의 사용 방법 |
| US20090062208A1 (en) * | 2007-02-06 | 2009-03-05 | Mochly-Rosen Daria D | Methods for maintaining blood-brain barrier integrity in hypertensive subjects using a delta-PKC inhibitor |
| JP2010523598A (ja) * | 2007-04-06 | 2010-07-15 | カイ・ファーマシューティカルズ・インコーポレイテッド | 痛みの軽減のためのガンマ阻害剤化合物の使用方法 |
| US20090137493A1 (en) * | 2007-06-07 | 2009-05-28 | Mochly-Rosen Daria D | Inhibition of tumor metastases using protein kinase C (PKC) inhibitors |
| US8975237B2 (en) | 2007-12-21 | 2015-03-10 | Coda Therapeutics, Inc. | Treatment of fibrotic conditions |
| US20090318351A1 (en) * | 2008-03-12 | 2009-12-24 | Kevin Grimes | Method of treating acute st-elevation myocardial infarction with a delta pkc antagonist |
| CN103083643B (zh) * | 2008-03-27 | 2015-01-07 | 雀巢产品技术援助有限公司 | 增加肽、肽模拟物和其他胃肠道转运蛋白底物吸收的方法 |
| WO2010019965A1 (en) * | 2008-08-15 | 2010-02-18 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for modulating epsilon protein kinase c-mediated cytoprotection |
| WO2010096746A1 (en) | 2009-02-20 | 2010-08-26 | Cellular Dynamics International, Inc. | Methods and compositions for the differentiation of stem cells |
| KR101720961B1 (ko) | 2009-02-27 | 2017-03-29 | 셀룰러 다이내믹스 인터내셔널, 인코포레이티드 | 다능성 세포의 분화 |
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| US20100311671A1 (en) * | 2009-03-25 | 2010-12-09 | Kai Pharmaceuticals | Transdermal delivery of pkc modulatory peptides through microporated skin |
| EP2482837A4 (en) | 2009-09-29 | 2013-05-22 | Joslin Diabetes Center Inc | USE OF PROTEIN KINASE C-DELTA (PKCD) INHIBITORS FOR THE TREATMENT OF DIABETES, ADIPOSITAS AND LIVER VARIATION |
| CA2795698A1 (en) * | 2010-03-05 | 2011-09-09 | Angstrom Pharmaceuticals, Inc. | Modulation of intracellular signaling |
| US8785648B1 (en) | 2010-08-10 | 2014-07-22 | The Regents Of The University Of California | PKC-epsilon inhibitors |
| EP2742057B1 (en) | 2011-08-12 | 2016-04-20 | The Board of Trustees of The Leland Stanford Junior University | Compositions and methods for specific regulation of pyruvate dehydrogenase kinase |
| WO2013163171A1 (en) | 2012-04-24 | 2013-10-31 | Kaufman Dan S | Method for developing natural killer cells from stem cells |
| ES2851724T3 (es) | 2013-09-18 | 2021-09-08 | Epiaxis Therapeutics Pty Ltd | Modulación de células madre |
| WO2016003450A1 (en) | 2014-07-01 | 2016-01-07 | The Regents Of The University Of California | Pkc-epsilon inhibitors |
| CA2958704A1 (en) | 2014-08-25 | 2016-03-03 | University Of Canberra | Compositions for modulating cancer stem cells and uses therefor |
| SG11201705591PA (en) | 2015-01-07 | 2017-08-30 | Trigemina Inc | Magnesium-containing oxytocin formulations and methods of use |
| JP7093559B2 (ja) | 2016-04-12 | 2022-06-30 | トライジェミナ， インコーポレイテッド | マグネシウム含有オキシトシン製剤および使用の方法 |
| US12410143B2 (en) | 2017-01-17 | 2025-09-09 | Michael David FORREST | Therapeutic inhibitors of the reverse mode of ATP synthase |
| BR112019028172A2 (pt) | 2017-07-13 | 2020-10-06 | Michael David Forrest | moduladores terapêuticos do modo reverso da atp sintase |
| WO2019090390A1 (en) | 2017-11-08 | 2019-05-16 | University Of Canberra | Immunogenic compositions and uses therefor |
| EP4078221A1 (en) * | 2019-12-16 | 2022-10-26 | Sony Semiconductor Solutions Corporation | Time-of-flight imaging circuitry, time-of-flight imaging system, time-of-flight imaging method |
| KR20220159945A (ko) * | 2020-03-31 | 2022-12-05 | 도레이 카부시키가이샤 | 화상 해석 장치, 화상 해석 장치의 제어 방법, 화상 해석 시스템, 및 화상 해석 시스템의 제어 방법 |
| MX2023007788A (es) | 2021-01-24 | 2023-11-17 | Michael David Forrest | Inhibidores de la atp sintasa, usos cosmeticos y terapeuticos. |
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| US4351829A (en) * | 1980-09-26 | 1982-09-28 | Farmitalia Carlo Erba Spa | Use of polypeptides as analgesic drugs |
| ES2123062T3 (es) | 1992-08-21 | 1999-01-01 | Biogen Inc | Polipeptidos de transporte derivados de la proteina tat. |
| US5776685A (en) * | 1993-07-19 | 1998-07-07 | Joslin Diabetes Center | Protein kinase C assay |
| US5783405A (en) | 1994-02-01 | 1998-07-21 | Terrapin Technologies, Inc. | Rapid screening method for effectors of signal transduction |
| US5935803A (en) | 1994-02-01 | 1999-08-10 | Terrapin Technologies, Inc. | Methods to identify immunomodulators using cognate interaction of PKC-theta |
| WO1998017299A1 (en) * | 1996-10-18 | 1998-04-30 | The Board Of Trustees Of The Leland Stanford Junior University | Isozyme-specific activators of protein kinase c, methods and compositions |
| US6376476B1 (en) * | 1996-12-13 | 2002-04-23 | Zymogenetics Corporation | Isoprenoid pathway inhibitors for stimulating bone growth |
| US6218113B1 (en) * | 1998-02-24 | 2001-04-17 | Incyte Genomics, Inc. | Human protein kinase C inhibitor |
| AU764760B2 (en) | 1998-07-06 | 2003-08-28 | Regents Of The University Of California, The | Use of inhibitors of protein kinase C epsilon to treat pain |
| US6376467B1 (en) * | 1998-10-09 | 2002-04-23 | The Regents Of The University Of California | Use of inhibitors of protein kinase C epsilon to treat pain |
| ATE276754T1 (de) * | 1998-07-21 | 2004-10-15 | Cytovia Inc | Neue fluoreszensfarbstoffe und ihre anwendung in fluoreszensnachweisverfahren ganzer zellen für kaspasen, peptidasen, proteasen und andere enzyme sowie deren verwendung |
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| WO2000018895A1 (en) * | 1998-09-25 | 2000-04-06 | The Children's Medical Center Corporation | Short peptides which selectively modulate the activity of protein kinases |
| GB9905218D0 (en) * | 1999-03-09 | 1999-04-28 | Univ Glasgow | Neurodegenerative disorder related gene |
| WO2001044497A2 (en) * | 1999-12-02 | 2001-06-21 | University Of Dundee | Protein kinase regulation |
| CN1300845A (zh) * | 1999-12-22 | 2001-06-27 | 上海博德基因开发有限公司 | 一种新的多肽－人二酰基甘油蛋白激酶亚单位9和编码这种多肽的多核苷酸 |
| US6436703B1 (en) | 2000-03-31 | 2002-08-20 | Hyseq, Inc. | Nucleic acids and polypeptides |
| US6496425B1 (en) * | 2000-08-21 | 2002-12-17 | Micron Technology, Inc | Multiple bit line column redundancy |
| WO2002057413A2 (en) * | 2001-01-18 | 2002-07-25 | The Board Of Trustees Of The Leland Stanford Junior University | Peptides for activation and inhibition of delta pkc |
| JP2005527209A (ja) | 2002-04-22 | 2005-09-15 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 疼痛管理のためのプロテインキナーゼＣγのペプチドインヒビター |
-
2003
- 2003-04-22 JP JP2003586177A patent/JP2005527209A/ja active Pending
- 2003-04-22 CA CA2482598A patent/CA2482598C/en not_active Expired - Fee Related
- 2003-04-22 AU AU2003234185A patent/AU2003234185C1/en not_active Ceased
- 2003-04-22 EP EP03728495A patent/EP1501533A4/en not_active Withdrawn
- 2003-04-22 US US10/421,548 patent/US7459424B2/en not_active Expired - Fee Related
- 2003-04-22 JP JP2003586176A patent/JP2005523326A/ja not_active Withdrawn
- 2003-04-22 US US10/421,503 patent/US7507711B2/en not_active Expired - Fee Related
- 2003-04-22 CA CA2785889A patent/CA2785889A1/en not_active Abandoned
- 2003-04-22 CA CA2481512A patent/CA2481512C/en not_active Expired - Fee Related
- 2003-04-22 AU AU2003234186A patent/AU2003234186B2/en not_active Ceased
- 2003-04-22 WO PCT/US2003/012541 patent/WO2003089456A2/en not_active Ceased
- 2003-04-22 US US10/513,003 patent/US7393835B2/en not_active Expired - Fee Related
- 2003-04-22 EP EP10178878A patent/EP2332559A1/en not_active Withdrawn
- 2003-04-22 EP EP03728494A patent/EP1501532A4/en not_active Withdrawn
- 2003-04-22 WO PCT/US2003/012542 patent/WO2003089457A2/en not_active Ceased
-
2007
- 2007-07-16 US US11/879,414 patent/US7833984B2/en not_active Expired - Fee Related
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2008
- 2008-06-16 US US12/214,104 patent/US7939493B2/en not_active Expired - Fee Related
- 2008-08-27 US US12/229,992 patent/US20090143293A1/en not_active Abandoned
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2009
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- 2009-01-21 JP JP2009011456A patent/JP2009102392A/ja active Pending
- 2009-04-22 AU AU2009201593A patent/AU2009201593B2/en not_active Ceased
- 2009-05-04 AU AU2009201760A patent/AU2009201760B2/en not_active Ceased
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2011
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2012
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2014
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