JP2005523085A5 - - Google Patents
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- JP2005523085A5 JP2005523085A5 JP2003585797A JP2003585797A JP2005523085A5 JP 2005523085 A5 JP2005523085 A5 JP 2005523085A5 JP 2003585797 A JP2003585797 A JP 2003585797A JP 2003585797 A JP2003585797 A JP 2003585797A JP 2005523085 A5 JP2005523085 A5 JP 2005523085A5
- Authority
- JP
- Japan
- Prior art keywords
- electrode
- electric field
- polarity
- electrodes
- row
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000005684 electric field Effects 0.000 claims description 100
- 239000000463 material Substances 0.000 claims description 11
- 210000001519 tissues Anatomy 0.000 claims description 9
- 239000000560 biocompatible material Substances 0.000 claims description 8
- 239000000126 substance Substances 0.000 claims description 8
- 230000003308 immunostimulating Effects 0.000 claims description 7
- 210000004027 cells Anatomy 0.000 claims description 6
- 238000001962 electrophoresis Methods 0.000 claims description 5
- 230000001225 therapeutic Effects 0.000 claims description 3
- 230000000091 immunopotentiator Effects 0.000 claims description 2
- 238000009169 immunotherapy Methods 0.000 claims description 2
- 239000011159 matrix material Substances 0.000 claims description 2
- 238000009503 electrostatic coating Methods 0.000 claims 13
- 239000003795 chemical substances by application Substances 0.000 claims 8
- 229960005486 vaccines Drugs 0.000 claims 8
- 239000007790 solid phase Substances 0.000 claims 5
- 230000000712 assembly Effects 0.000 claims 4
- 239000002904 solvent Substances 0.000 claims 3
- 229920000160 (ribonucleotides)n+m Polymers 0.000 claims 2
- 229920003013 deoxyribonucleic acid Polymers 0.000 claims 2
- 210000000056 organs Anatomy 0.000 claims 2
- 229920000023 polynucleotide Polymers 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 210000001124 Body Fluids Anatomy 0.000 claims 1
- 229920002521 Macromolecule Polymers 0.000 claims 1
- 210000003205 Muscles Anatomy 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 210000003491 Skin Anatomy 0.000 claims 1
- 210000004927 Skin cells Anatomy 0.000 claims 1
- 210000004304 Subcutaneous Tissue Anatomy 0.000 claims 1
- 239000010839 body fluid Substances 0.000 claims 1
- 230000001413 cellular Effects 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drugs Drugs 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000001264 neutralization Effects 0.000 claims 1
- 238000010586 diagram Methods 0.000 description 10
- 238000004520 electroporation Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 2
- 238000005868 electrolysis reaction Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 210000004962 mammalian cells Anatomy 0.000 description 1
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37243602P | 2002-04-16 | 2002-04-16 | |
PCT/US2003/009208 WO2003089046A1 (en) | 2002-04-16 | 2003-04-11 | Method of treating biological materials with translating electrical fields and electrode polarity reversal |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2005523085A JP2005523085A (ja) | 2005-08-04 |
JP2005523085A5 true JP2005523085A5 (de) | 2009-03-05 |
JP4499427B2 JP4499427B2 (ja) | 2010-07-07 |
Family
ID=29250852
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2003585797A Expired - Fee Related JP4499427B2 (ja) | 2002-04-16 | 2003-04-11 | 電場の移動及び電極極性の反転で生体材料を処理する方法。 |
Country Status (9)
Country | Link |
---|---|
US (1) | US20060089674A1 (de) |
EP (1) | EP1494752B1 (de) |
JP (1) | JP4499427B2 (de) |
CN (1) | CN100455328C (de) |
AT (1) | ATE402732T1 (de) |
AU (1) | AU2003223351A1 (de) |
CA (1) | CA2482183A1 (de) |
DE (1) | DE60322523D1 (de) |
WO (1) | WO2003089046A1 (de) |
Families Citing this family (68)
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USRE44145E1 (en) | 2000-07-07 | 2013-04-09 | A.V. Topchiev Institute Of Petrochemical Synthesis | Preparation of hydrophilic pressure sensitive adhesives having optimized adhesive properties |
US8728445B2 (en) | 2001-05-01 | 2014-05-20 | A.V. Topchiev Institute Of Petrochemical Synthesis, Russian Academy Of Sciences | Hydrogel Compositions |
US8840918B2 (en) | 2001-05-01 | 2014-09-23 | A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences | Hydrogel compositions for tooth whitening |
US20050215727A1 (en) | 2001-05-01 | 2005-09-29 | Corium | Water-absorbent adhesive compositions and associated methods of manufacture and use |
US8541021B2 (en) | 2001-05-01 | 2013-09-24 | A.V. Topchiev Institute Of Petrochemical Synthesis | Hydrogel compositions demonstrating phase separation on contact with aqueous media |
US8206738B2 (en) | 2001-05-01 | 2012-06-26 | Corium International, Inc. | Hydrogel compositions with an erodible backing member |
US6978174B2 (en) | 2002-04-08 | 2005-12-20 | Ardian, Inc. | Methods and devices for renal nerve blocking |
US8150519B2 (en) * | 2002-04-08 | 2012-04-03 | Ardian, Inc. | Methods and apparatus for bilateral renal neuromodulation |
US7653438B2 (en) | 2002-04-08 | 2010-01-26 | Ardian, Inc. | Methods and apparatus for renal neuromodulation |
US8347891B2 (en) | 2002-04-08 | 2013-01-08 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and apparatus for performing a non-continuous circumferential treatment of a body lumen |
US8774913B2 (en) | 2002-04-08 | 2014-07-08 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and apparatus for intravasculary-induced neuromodulation |
US7756583B2 (en) | 2002-04-08 | 2010-07-13 | Ardian, Inc. | Methods and apparatus for intravascularly-induced neuromodulation |
US20070129761A1 (en) | 2002-04-08 | 2007-06-07 | Ardian, Inc. | Methods for treating heart arrhythmia |
US8145316B2 (en) | 2002-04-08 | 2012-03-27 | Ardian, Inc. | Methods and apparatus for renal neuromodulation |
US7162303B2 (en) | 2002-04-08 | 2007-01-09 | Ardian, Inc. | Renal nerve stimulation method and apparatus for treatment of patients |
US7853333B2 (en) * | 2002-04-08 | 2010-12-14 | Ardian, Inc. | Methods and apparatus for multi-vessel renal neuromodulation |
US8175711B2 (en) | 2002-04-08 | 2012-05-08 | Ardian, Inc. | Methods for treating a condition or disease associated with cardio-renal function |
US20070135875A1 (en) | 2002-04-08 | 2007-06-14 | Ardian, Inc. | Methods and apparatus for thermally-induced renal neuromodulation |
US8145317B2 (en) * | 2002-04-08 | 2012-03-27 | Ardian, Inc. | Methods for renal neuromodulation |
US9308044B2 (en) | 2002-04-08 | 2016-04-12 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for therapeutic renal neuromodulation |
US8774922B2 (en) | 2002-04-08 | 2014-07-08 | Medtronic Ardian Luxembourg S.A.R.L. | Catheter apparatuses having expandable balloons for renal neuromodulation and associated systems and methods |
US9308043B2 (en) | 2002-04-08 | 2016-04-12 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for monopolar renal neuromodulation |
US7620451B2 (en) | 2005-12-29 | 2009-11-17 | Ardian, Inc. | Methods and apparatus for pulsed electric field neuromodulation via an intra-to-extravascular approach |
US20080213331A1 (en) | 2002-04-08 | 2008-09-04 | Ardian, Inc. | Methods and devices for renal nerve blocking |
US7617005B2 (en) | 2002-04-08 | 2009-11-10 | Ardian, Inc. | Methods and apparatus for thermally-induced renal neuromodulation |
US8131371B2 (en) * | 2002-04-08 | 2012-03-06 | Ardian, Inc. | Methods and apparatus for monopolar renal neuromodulation |
US20140018880A1 (en) | 2002-04-08 | 2014-01-16 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for monopolar renal neuromodulation |
US9636174B2 (en) | 2002-04-08 | 2017-05-02 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for therapeutic renal neuromodulation |
US20040082859A1 (en) | 2002-07-01 | 2004-04-29 | Alan Schaer | Method and apparatus employing ultrasound energy to treat body sphincters |
CA2554649C (en) | 2004-01-30 | 2015-10-27 | Corium International, Inc. | Rapidly dissolving film for delivery of an active agent |
US7775087B2 (en) * | 2004-03-16 | 2010-08-17 | Northwestern University | Microchannel forming method and nanotipped dispensing device having a microchannel |
CA2572122A1 (fr) * | 2004-06-24 | 2006-02-02 | Sphergen | Dispositif pour le transfert de molecules aux cellules utilisant une force electrique |
EP1791575B1 (de) | 2004-08-05 | 2014-10-08 | Corium International, Inc. | Klebstoffzusammensetzung |
US7937143B2 (en) | 2004-11-02 | 2011-05-03 | Ardian, Inc. | Methods and apparatus for inducing controlled renal neuromodulation |
CA2612866A1 (en) * | 2005-05-11 | 2006-11-23 | Corium International, Inc. | Permeabilization of biological membranes |
US8353906B2 (en) * | 2005-08-01 | 2013-01-15 | Ceramatec, Inc. | Electrochemical probe and method for in situ treatment of a tissue |
JP5032500B2 (ja) * | 2006-01-03 | 2012-09-26 | アルコン,インコーポレイティド | 蛋白性組織の解離及び除去のためのシステム |
WO2007095140A2 (en) * | 2006-02-11 | 2007-08-23 | Genetronics, Inc. | Device and method for single-needle in vivo electroporation |
US20080287857A1 (en) * | 2006-02-11 | 2008-11-20 | Rune Kjeken | Device and method for single-needle in vivo electroporation |
EP2160201B1 (de) * | 2007-05-21 | 2014-04-09 | Cellectis | Vorrichtung zur verabreichung von polynukleotidimpfstoffen an säugerhaut |
TWI401432B (zh) * | 2008-12-05 | 2013-07-11 | Univ Nat Taiwan | 高密度微電極陣列及其序列式控制方法 |
US8652129B2 (en) | 2008-12-31 | 2014-02-18 | Medtronic Ardian Luxembourg S.A.R.L. | Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation |
US8974445B2 (en) | 2009-01-09 | 2015-03-10 | Recor Medical, Inc. | Methods and apparatus for treatment of cardiac valve insufficiency |
US8784879B2 (en) | 2009-01-14 | 2014-07-22 | Corium International, Inc. | Transdermal administration of tamsulosin |
US20110118729A1 (en) * | 2009-11-13 | 2011-05-19 | Alcon Research, Ltd | High-intensity pulsed electric field vitrectomy apparatus with load detection |
US20110118734A1 (en) * | 2009-11-16 | 2011-05-19 | Alcon Research, Ltd. | Capsularhexis device using pulsed electric fields |
US20110135626A1 (en) * | 2009-12-08 | 2011-06-09 | Alcon Research, Ltd. | Localized Chemical Lysis of Ocular Tissue |
US20110144562A1 (en) * | 2009-12-14 | 2011-06-16 | Alcon Research, Ltd. | Localized Pharmacological Treatment of Ocular Tissue Using High-Intensity Pulsed Electrical Fields |
US20110144641A1 (en) * | 2009-12-15 | 2011-06-16 | Alcon Research, Ltd. | High-Intensity Pulsed Electric Field Vitrectomy Apparatus |
US8546979B2 (en) | 2010-08-11 | 2013-10-01 | Alcon Research, Ltd. | Self-matching pulse generator with adjustable pulse width and pulse frequency |
CN103313671B (zh) | 2010-10-25 | 2017-06-06 | 美敦力Af卢森堡有限责任公司 | 用于神经调节治疗的估算及反馈的装置、系统及方法 |
CN104271062B (zh) | 2012-03-08 | 2017-07-07 | 美敦力Af卢森堡有限责任公司 | 采用神经调节装置的生物标志物取样和相关系统及方法 |
WO2013134548A2 (en) | 2012-03-08 | 2013-09-12 | Medtronic Ardian Luxembourg S.A.R.L. | Ovarian neuromodulation and associated systems and methods |
US20140110296A1 (en) | 2012-10-19 | 2014-04-24 | Medtronic Ardian Luxembourg S.A.R.L. | Packaging for Catheter Treatment Devices and Associated Devices, Systems, and Methods |
WO2014201511A1 (en) * | 2013-06-21 | 2014-12-24 | Gary David Housley | Method and apparatus for close-field electroporation |
CN103555574A (zh) | 2013-11-11 | 2014-02-05 | 苏州文曲生物微系统有限公司 | 一种流式电穿孔装置 |
KR102171496B1 (ko) * | 2013-12-05 | 2020-10-30 | 알에프이엠비 홀딩스, 엘엘씨 | 면역 요법을 위한 보조 메커니즘으로서의 고주파 전기막 파괴(rf-emb)에 의한 암 항원의 항원표출세포로의 개선된 표출 시스템 |
US9980766B1 (en) | 2014-03-28 | 2018-05-29 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and systems for renal neuromodulation |
US10194980B1 (en) | 2014-03-28 | 2019-02-05 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for catheter-based renal neuromodulation |
US10194979B1 (en) | 2014-03-28 | 2019-02-05 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for catheter-based renal neuromodulation |
US9833617B2 (en) * | 2014-07-25 | 2017-12-05 | Loyalty Based Innovations, LLC | Apparatus and method for treating multiple tumors in patients with metastatic disease by electric fields |
KR101788301B1 (ko) * | 2015-09-17 | 2017-10-20 | 주식회사 엘림텍 | 전기천공장치 및 그 제어방법 |
GB2554455A (en) * | 2016-09-29 | 2018-04-04 | Feeligreen Sa | Skin treatment device and method for delivery of an active ingredient into the human skin by means of iontophoresis, using an array of electrodes |
CN106955418A (zh) * | 2017-04-19 | 2017-07-18 | 湖南省万卓医疗器械有限公司 | 可动态调度电极板极性的三维动态治疗仪 |
ES2949058T3 (es) * | 2018-11-05 | 2023-09-25 | Region Hovedstaden V/Herlev Hospital | Un conjunto de electrodos para mejorar la distribución del campo eléctrico |
EP3893986A4 (de) * | 2018-12-13 | 2022-08-24 | NewSouth Innovations Pty Limited | Verfahren und system zur steuerung der molekularen elektroübertragung |
EP3937810A1 (de) * | 2019-03-15 | 2022-01-19 | Boston Scientific Scimed, Inc. | Räumlich gemultiplexte wellenform zur selektiven zellablation |
EP4230718A3 (de) | 2019-09-02 | 2023-10-18 | Mirai Medical Limited | Elektroporationsvorrichtung und -verfahren |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2703253B1 (fr) | 1993-03-30 | 1995-06-23 | Centre Nat Rech Scient | Applicateur d'impulsions electriques pour traitement de tissus biologiques. |
US5702359A (en) * | 1995-06-06 | 1997-12-30 | Genetronics, Inc. | Needle electrodes for mediated delivery of drugs and genes |
US5993434A (en) | 1993-04-01 | 1999-11-30 | Genetronics, Inc. | Method of treatment using electroporation mediated delivery of drugs and genes |
US6010613A (en) * | 1995-12-08 | 2000-01-04 | Cyto Pulse Sciences, Inc. | Method of treating materials with pulsed electrical fields |
CA2249602A1 (en) * | 1996-04-04 | 1997-10-16 | Medtronic, Inc. | Living tissue stimulation and recording techniques |
JP2001520537A (ja) | 1997-04-03 | 2001-10-30 | エレクトロフェクト・アクティーゼルスカブ | 医薬品と核酸の骨格筋への導入方法 |
US5873849A (en) | 1997-04-24 | 1999-02-23 | Ichor Medical Systems, Inc. | Electrodes and electrode arrays for generating electroporation inducing electrical fields |
US6117660A (en) * | 1997-06-10 | 2000-09-12 | Cytopulse Sciences, Inc. | Method and apparatus for treating materials with electrical fields having varying orientations |
US6055453A (en) | 1997-08-01 | 2000-04-25 | Genetronics, Inc. | Apparatus for addressing needle array electrodes for electroporation therapy |
US6241701B1 (en) * | 1997-08-01 | 2001-06-05 | Genetronics, Inc. | Apparatus for electroporation mediated delivery of drugs and genes |
US7456012B2 (en) * | 1997-11-06 | 2008-11-25 | Cellectricon Ab | Method and apparatus for spatially confined electroporation |
US6208893B1 (en) * | 1998-01-27 | 2001-03-27 | Genetronics, Inc. | Electroporation apparatus with connective electrode template |
CN1233511A (zh) * | 1998-04-24 | 1999-11-03 | 刘凤瑞 | 循环脉冲序列仿真治疗仪 |
JP4499295B2 (ja) * | 1999-01-28 | 2010-07-07 | サイト パルス サイエンシズ、インコーポレイテッド | 細胞内への巨大分子の送達 |
US6713291B2 (en) * | 1999-01-28 | 2004-03-30 | Alan D. King | Electrodes coated with treating agent and uses thereof |
US6428504B1 (en) * | 2000-04-06 | 2002-08-06 | Varian Medical Systems, Inc. | Multipurpose template and needles for the delivery and monitoring of multiple minimally invasive therapies |
US6546290B1 (en) * | 2000-04-12 | 2003-04-08 | Roamitron Holding S.A. | Method and apparatus for electromedical therapy |
US6795728B2 (en) * | 2001-08-17 | 2004-09-21 | Minnesota Medical Physics, Llc | Apparatus and method for reducing subcutaneous fat deposits by electroporation |
-
2003
- 2003-04-11 EP EP03719469A patent/EP1494752B1/de not_active Expired - Lifetime
- 2003-04-11 DE DE60322523T patent/DE60322523D1/de not_active Expired - Fee Related
- 2003-04-11 AU AU2003223351A patent/AU2003223351A1/en not_active Abandoned
- 2003-04-11 AT AT03719469T patent/ATE402732T1/de not_active IP Right Cessation
- 2003-04-11 US US10/510,710 patent/US20060089674A1/en not_active Abandoned
- 2003-04-11 CN CNB038131641A patent/CN100455328C/zh not_active Expired - Fee Related
- 2003-04-11 WO PCT/US2003/009208 patent/WO2003089046A1/en active Application Filing
- 2003-04-11 CA CA002482183A patent/CA2482183A1/en not_active Abandoned
- 2003-04-11 JP JP2003585797A patent/JP4499427B2/ja not_active Expired - Fee Related
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