JP2005521873A - マルチチャンバ型ポンプ−バルブ装置 - Google Patents
マルチチャンバ型ポンプ−バルブ装置 Download PDFInfo
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- JP2005521873A JP2005521873A JP2003580834A JP2003580834A JP2005521873A JP 2005521873 A JP2005521873 A JP 2005521873A JP 2003580834 A JP2003580834 A JP 2003580834A JP 2003580834 A JP2003580834 A JP 2003580834A JP 2005521873 A JP2005521873 A JP 2005521873A
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Images
Classifications
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- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/56—Labware specially adapted for transferring fluids
- B01L3/563—Joints or fittings ; Separable fluid transfer means to transfer fluids between at least two containers, e.g. connectors
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/40—Static mixers
- B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
- B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
- B01F25/433—Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/40—Static mixers
- B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
- B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
- B01F25/433—Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
- B01F25/4335—Mixers with a converging-diverging cross-section
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
- B01F31/65—Mixers with shaking, oscillating, or vibrating mechanisms the materials to be mixed being directly submitted to a pulsating movement, e.g. by means of an oscillating piston or air column
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/71—Feed mechanisms
- B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
- B01F35/7174—Feed mechanisms characterised by the means for feeding the components to the mixer using pistons, plungers or syringes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0478—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure pistons
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
- B01L3/0217—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
- G01N1/14—Suction devices, e.g. pumps; Ejector devices
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/405—Concentrating samples by adsorption or absorption
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
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- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
- G01N2030/326—Control of physical parameters of the fluid carrier of pressure or speed pumps
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1095—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers
- G01N35/1097—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers characterised by the valves
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Clinical Laboratory Science (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Sampling And Sample Adjustment (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/107,622 US6820506B2 (en) | 2002-03-27 | 2002-03-27 | Multi-chambered pump-valve device |
| PCT/US2003/004160 WO2003083444A1 (en) | 2002-03-27 | 2003-02-11 | Multi-chambered pump-valve device |
Related Child Applications (1)
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| JP2008211033A Division JP2008275649A (ja) | 2002-03-27 | 2008-08-19 | マルチチャンバ型ポンプ−バルブ装置 |
Publications (2)
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| JP2005521873A true JP2005521873A (ja) | 2005-07-21 |
| JP2005521873A5 JP2005521873A5 (enExample) | 2006-03-30 |
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| JP2008211033A Withdrawn JP2008275649A (ja) | 2002-03-27 | 2008-08-19 | マルチチャンバ型ポンプ−バルブ装置 |
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|---|---|---|---|
| JP2008211033A Withdrawn JP2008275649A (ja) | 2002-03-27 | 2008-08-19 | マルチチャンバ型ポンプ−バルブ装置 |
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| US (2) | US6820506B2 (enExample) |
| EP (1) | EP1490664A4 (enExample) |
| JP (2) | JP2005521873A (enExample) |
| AU (1) | AU2003210981A1 (enExample) |
| CA (1) | CA2477806A1 (enExample) |
| WO (1) | WO2003083444A1 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007535401A (ja) * | 2004-04-30 | 2007-12-06 | マルムクヴィスト，マッツ | 閉鎖型反応容器システム |
| JP2013213784A (ja) * | 2012-04-04 | 2013-10-17 | Rohm Co Ltd | 検体採取器具 |
| JP2023546928A (ja) * | 2020-11-12 | 2023-11-08 | ザ プロクター アンド ギャンブル カンパニー | 容積式混合器 |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4148894B2 (ja) * | 2001-10-16 | 2008-09-10 | マトリックス・テクノロジイズ・コーポレーション | 手持ち式ピペット |
| US20060027033A1 (en) * | 2002-10-16 | 2006-02-09 | Richard Cote | Hand-held pipette employing voice recognition control |
| USD545449S1 (en) * | 2005-02-15 | 2007-06-26 | Serenex, Inc. | Gel band picking head |
| FR2914566B1 (fr) * | 2007-04-05 | 2009-05-22 | Univ Louis Pasteur Etablisseme | Dispositif melangeur modulaire et instrumente pour le melange d'au moins deux matieres visqueuses. |
| WO2008147281A1 (en) * | 2007-05-30 | 2008-12-04 | Ge Healthcare Bio-Sciences Ab | Device and method for separation of proteins and other biomolecules |
| WO2009032645A1 (en) * | 2007-09-06 | 2009-03-12 | Siemens Healthcare Diagnostics, Inc. | Reagent cartridge |
| US8246552B2 (en) * | 2007-09-19 | 2012-08-21 | Nastaran Minassians | Closed specimen collection system |
| US8719420B2 (en) * | 2008-05-13 | 2014-05-06 | At&T Mobility Ii Llc | Administration of access lists for femtocell service |
| US8633016B2 (en) * | 2008-09-30 | 2014-01-21 | Covidien Lp | Microbial detection assembly |
| US8973749B2 (en) | 2010-06-29 | 2015-03-10 | Biolyph, L.L.C. | Reagent preparation assembly |
| AU2010363976B2 (en) * | 2010-11-18 | 2015-05-21 | Biolyph, Llc | Reagent preparation and dispensing device |
| JP6116490B2 (ja) | 2011-03-09 | 2017-04-19 | ピクセル メディカル テクノロジーズ リミテッド | 分析対象の細胞を含む試料流体の調製に用いる使い捨てカートリッジ |
| US8870028B2 (en) | 2012-05-25 | 2014-10-28 | Restek Corporation | Dispensing device |
| US10386353B1 (en) * | 2017-06-26 | 2019-08-20 | Omar Nabil Metwally | Serial chemical extraction and spectrometric analysis system |
| GB201907537D0 (en) | 2019-05-29 | 2019-07-10 | Waterford Institute Of Tech | Modular sample processing device |
| WO2024137514A1 (en) | 2022-12-22 | 2024-06-27 | Synthego Corporation | Systems and method for automated oligonucleotide synthesis |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08301775A (ja) * | 1995-03-24 | 1996-11-19 | Johnson & Johnson Medical Inc | 自家移植用血漿とフィブリンゲルの調合 |
| JP2000035434A (ja) * | 1998-07-06 | 2000-02-02 | Bayer Corp | 液体試験パッケ―ジの流れの制御法及び制御装置 |
| WO2002009857A1 (en) * | 2000-07-27 | 2002-02-07 | Asahi Medical Co., Ltd. | Modified hollow-fiber membrane |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3493503A (en) | 1967-05-19 | 1970-02-03 | Haematronics Inc | Method of producing a protein-free fluid |
| US4138474A (en) | 1973-05-01 | 1979-02-06 | Wisconsin Alumni Research Foundation | Method and device for immunoassay |
| US3917451A (en) * | 1973-07-02 | 1975-11-04 | Gen Electric | Electrokinetic streaming current detection |
| US4889692A (en) * | 1984-11-05 | 1989-12-26 | Holtzman Marc E | Disposable sample preparation container |
| US4840730A (en) | 1986-07-25 | 1989-06-20 | Sepragen Corporation | Chromatography system using horizontal flow columns |
| DK475386D0 (da) * | 1986-10-03 | 1986-10-03 | Weis Fogh Ulla Sivertsen | Fremgangsmaade og apparat til fremstilling af biologiske stoffer |
| US4908187A (en) * | 1987-04-01 | 1990-03-13 | Endowment For Research In Human Biology, Inc. | Device for diluting and mixing liquids and applications for kinetic analysis |
| US4892710A (en) | 1987-07-07 | 1990-01-09 | Bioprobe International, Inc. | Cartridge assembly with multi-purpose closure tubing |
| WO1991003298A1 (en) * | 1989-08-31 | 1991-03-21 | Union Oil Company Of California | Continuous high performance liquid chromatography |
| US5102407A (en) * | 1990-03-13 | 1992-04-07 | Miles Inc. | Blood separation system |
| DK119490D0 (da) * | 1990-05-14 | 1990-05-14 | Unes As | Apparat til fremstilling af et koncentrat af koagulationsfaktorer, saasom fibrinogen, fra en blodportion |
| US5114858A (en) | 1990-06-26 | 1992-05-19 | E. I. Du Pont De Nemours And Company | Cellular component extraction process in a disposable filtration vessel |
| ZA948564B (en) * | 1993-11-19 | 1995-07-26 | Bristol Myers Squibb Co | Liquid separation apparatus and method |
| CA2222506C (en) * | 1995-06-06 | 2007-07-24 | Quantic Biomedical Partners | Device and method for concentrating plasma |
| US5885789A (en) * | 1997-03-20 | 1999-03-23 | Stc Technologies Incorporated | Solution-based assay for peroxidatively-active substances in bodily fluids |
| US6048457A (en) | 1997-02-26 | 2000-04-11 | Millipore Corporation | Cast membrane structures for sample preparation |
| US5786182A (en) | 1997-05-02 | 1998-07-28 | Biomerieux Vitek, Inc. | Dual chamber disposable reaction vessel for amplification reactions, reaction processing station therefor, and methods of use |
| US5895764A (en) * | 1997-11-24 | 1999-04-20 | University Of New Mexico | Controlled sheath flow injection cytometry |
| US6350987B1 (en) * | 1998-03-31 | 2002-02-26 | Dexter B. Northrup | Enzymatic reaction mechanisms by quenched-flow mass spectrometry |
| US6019897A (en) | 1998-08-20 | 2000-02-01 | Dyax Corporation | System for simultaneously pumping solvent for a plurality of chromatography columns |
| WO2001019484A1 (en) | 1999-09-13 | 2001-03-22 | Dyax Corporation | Purification device and purification method |
| SE9904539D0 (sv) | 1999-12-10 | 1999-12-10 | Alphahelix Ab | Method and device for the handling of samples and reagents |
| US6395229B1 (en) | 2000-05-22 | 2002-05-28 | Michael Markelov | Headspace sampling apparatus and method |
-
2002
- 2002-03-27 US US10/107,622 patent/US6820506B2/en not_active Expired - Fee Related
-
2003
- 2003-02-11 AU AU2003210981A patent/AU2003210981A1/en not_active Abandoned
- 2003-02-11 EP EP03745512A patent/EP1490664A4/en not_active Withdrawn
- 2003-02-11 JP JP2003580834A patent/JP2005521873A/ja not_active Withdrawn
- 2003-02-11 WO PCT/US2003/004160 patent/WO2003083444A1/en not_active Ceased
- 2003-02-11 CA CA002477806A patent/CA2477806A1/en not_active Abandoned
-
2004
- 2004-08-27 US US10/927,761 patent/US6915713B2/en not_active Expired - Fee Related
-
2008
- 2008-08-19 JP JP2008211033A patent/JP2008275649A/ja not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08301775A (ja) * | 1995-03-24 | 1996-11-19 | Johnson & Johnson Medical Inc | 自家移植用血漿とフィブリンゲルの調合 |
| JP2000035434A (ja) * | 1998-07-06 | 2000-02-02 | Bayer Corp | 液体試験パッケ―ジの流れの制御法及び制御装置 |
| WO2002009857A1 (en) * | 2000-07-27 | 2002-02-07 | Asahi Medical Co., Ltd. | Modified hollow-fiber membrane |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007535401A (ja) * | 2004-04-30 | 2007-12-06 | マルムクヴィスト，マッツ | 閉鎖型反応容器システム |
| JP2013213784A (ja) * | 2012-04-04 | 2013-10-17 | Rohm Co Ltd | 検体採取器具 |
| JP2023546928A (ja) * | 2020-11-12 | 2023-11-08 | ザ プロクター アンド ギャンブル カンパニー | 容積式混合器 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003083444A1 (en) | 2003-10-09 |
| CA2477806A1 (en) | 2003-10-09 |
| JP2008275649A (ja) | 2008-11-13 |
| US20030183020A1 (en) | 2003-10-02 |
| AU2003210981A1 (en) | 2003-10-13 |
| EP1490664A1 (en) | 2004-12-29 |
| EP1490664A4 (en) | 2005-10-12 |
| US6820506B2 (en) | 2004-11-23 |
| US6915713B2 (en) | 2005-07-12 |
| US20050031493A1 (en) | 2005-02-10 |
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