JP2005519888A5 - - Google Patents
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- Publication number
- JP2005519888A5 JP2005519888A5 JP2003556052A JP2003556052A JP2005519888A5 JP 2005519888 A5 JP2005519888 A5 JP 2005519888A5 JP 2003556052 A JP2003556052 A JP 2003556052A JP 2003556052 A JP2003556052 A JP 2003556052A JP 2005519888 A5 JP2005519888 A5 JP 2005519888A5
- Authority
- JP
- Japan
- Prior art keywords
- methoxamine
- salt
- pharmaceutical composition
- composition according
- physiologically tolerated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229960005192 methoxamine Drugs 0.000 claims 48
- 150000003839 salts Chemical class 0.000 claims 41
- 239000008194 pharmaceutical composition Substances 0.000 claims 29
- 238000000034 method Methods 0.000 claims 9
- 239000000203 mixture Substances 0.000 claims 8
- 230000002496 gastric effect Effects 0.000 claims 5
- WJAJPNHVVFWKKL-UHFFFAOYSA-N Methoxamine Chemical compound COC1=CC=C(OC)C(C(O)C(C)N)=C1 WJAJPNHVVFWKKL-UHFFFAOYSA-N 0.000 claims 4
- 125000003277 amino group Chemical group 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 210000002255 anal canal Anatomy 0.000 claims 3
- 230000003111 delayed effect Effects 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- 239000005526 vasoconstrictor agent Substances 0.000 claims 3
- VSMILISQVUOHED-ZETCQYMHSA-N (2s)-2-amino-1-(2,5-dimethoxyphenyl)propan-1-one Chemical compound COC1=CC=C(OC)C(C(=O)[C@H](C)N)=C1 VSMILISQVUOHED-ZETCQYMHSA-N 0.000 claims 2
- MZRVEZGGRBJDDB-UHFFFAOYSA-N N-Butyllithium Chemical compound [Li]CCCC MZRVEZGGRBJDDB-UHFFFAOYSA-N 0.000 claims 2
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 claims 2
- 239000012501 chromatography medium Substances 0.000 claims 2
- 210000001072 colon Anatomy 0.000 claims 2
- 229920001577 copolymer Polymers 0.000 claims 2
- 239000006071 cream Substances 0.000 claims 2
- QKIUAMUSENSFQQ-UHFFFAOYSA-N dimethylazanide Chemical compound C[N-]C QKIUAMUSENSFQQ-UHFFFAOYSA-N 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000002674 ointment Substances 0.000 claims 2
- 210000002460 smooth muscle Anatomy 0.000 claims 2
- 210000005070 sphincter Anatomy 0.000 claims 2
- WJAJPNHVVFWKKL-CPCISQLKSA-N (1r,2s)-2-amino-1-(2,5-dimethoxyphenyl)propan-1-ol Chemical compound COC1=CC=C(OC)C([C@@H](O)[C@H](C)N)=C1 WJAJPNHVVFWKKL-CPCISQLKSA-N 0.000 claims 1
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 claims 1
- DWCGNRKFLRLWCJ-UHFFFAOYSA-N 2-bromo-1,4-dimethoxybenzene Chemical compound COC1=CC=C(OC)C(Br)=C1 DWCGNRKFLRLWCJ-UHFFFAOYSA-N 0.000 claims 1
- 206010002091 Anaesthesia Diseases 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- 229920000858 Cyclodextrin Polymers 0.000 claims 1
- 206010012735 Diarrhoea Diseases 0.000 claims 1
- 239000001116 FEMA 4028 Substances 0.000 claims 1
- 208000034347 Faecal incontinence Diseases 0.000 claims 1
- 208000001953 Hypotension Diseases 0.000 claims 1
- 206010028735 Nasal congestion Diseases 0.000 claims 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical group O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 239000000853 adhesive Substances 0.000 claims 1
- 230000001070 adhesive effect Effects 0.000 claims 1
- 239000000695 adrenergic alpha-agonist Substances 0.000 claims 1
- 239000000443 aerosol Substances 0.000 claims 1
- 230000037005 anaesthesia Effects 0.000 claims 1
- 229940124572 antihypotensive agent Drugs 0.000 claims 1
- 210000000436 anus Anatomy 0.000 claims 1
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims 1
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims 1
- 229960004853 betadex Drugs 0.000 claims 1
- 230000036772 blood pressure Effects 0.000 claims 1
- 210000001217 buttock Anatomy 0.000 claims 1
- 230000000747 cardiac effect Effects 0.000 claims 1
- 230000015556 catabolic process Effects 0.000 claims 1
- 239000011248 coating agent Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 230000000112 colonic effect Effects 0.000 claims 1
- 238000001816 cooling Methods 0.000 claims 1
- 238000006731 degradation reaction Methods 0.000 claims 1
- OIKHZBFJHONJJB-UHFFFAOYSA-N dimethyl(phenyl)silicon Chemical compound C[Si](C)C1=CC=CC=C1 OIKHZBFJHONJJB-UHFFFAOYSA-N 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 239000003480 eluent Substances 0.000 claims 1
- 210000000981 epithelium Anatomy 0.000 claims 1
- 239000006260 foam Substances 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 230000004217 heart function Effects 0.000 claims 1
- 238000004128 high performance liquid chromatography Methods 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 230000036543 hypotension Effects 0.000 claims 1
- 238000011065 in-situ storage Methods 0.000 claims 1
- 238000001802 infusion Methods 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 210000005072 internal anal sphincter Anatomy 0.000 claims 1
- XMJHPCRAQCTCFT-UHFFFAOYSA-N methyl chloroformate Chemical compound COC(Cl)=O XMJHPCRAQCTCFT-UHFFFAOYSA-N 0.000 claims 1
- 230000002911 mydriatic effect Effects 0.000 claims 1
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 claims 1
- 210000002850 nasal mucosa Anatomy 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 239000006072 paste Substances 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 210000001187 pylorus Anatomy 0.000 claims 1
- 238000004366 reverse phase liquid chromatography Methods 0.000 claims 1
- 239000000741 silica gel Substances 0.000 claims 1
- 229910002027 silica gel Inorganic materials 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 238000007910 systemic administration Methods 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0130763.6A GB0130763D0 (en) | 2001-12-21 | 2001-12-21 | Treatment methods |
| GB0130763.6 | 2001-12-21 | ||
| PCT/GB2002/005864 WO2003055474A1 (en) | 2001-12-21 | 2002-12-20 | Treatment of faecal incontinence and other conditions with 1r, 2s-methoxamine |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011041076A Division JP2011105770A (ja) | 2001-12-21 | 2011-02-28 | １ｒ，２ｓ−メトキサミンを用いた便失禁および他の状態の処置 |
| JP2011241937A Division JP5544535B2 (ja) | 2001-12-21 | 2011-11-04 | １ｒ，２ｓ−メトキサミンを用いた便失禁および他の状態の処置 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005519888A JP2005519888A (ja) | 2005-07-07 |
| JP2005519888A5 true JP2005519888A5 (enExample) | 2006-02-09 |
| JP5486143B2 JP5486143B2 (ja) | 2014-05-07 |
Family
ID=9928258
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003556052A Expired - Fee Related JP5486143B2 (ja) | 2001-12-21 | 2002-12-20 | １ｒ，２ｓ−メトキサミンを用いた便失禁および他の状態の処置 |
| JP2011041076A Pending JP2011105770A (ja) | 2001-12-21 | 2011-02-28 | １ｒ，２ｓ−メトキサミンを用いた便失禁および他の状態の処置 |
| JP2011241937A Expired - Fee Related JP5544535B2 (ja) | 2001-12-21 | 2011-11-04 | １ｒ，２ｓ−メトキサミンを用いた便失禁および他の状態の処置 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011041076A Pending JP2011105770A (ja) | 2001-12-21 | 2011-02-28 | １ｒ，２ｓ−メトキサミンを用いた便失禁および他の状態の処置 |
| JP2011241937A Expired - Fee Related JP5544535B2 (ja) | 2001-12-21 | 2011-11-04 | １ｒ，２ｓ−メトキサミンを用いた便失禁および他の状態の処置 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US20050096397A1 (enExample) |
| EP (2) | EP2275099A1 (enExample) |
| JP (3) | JP5486143B2 (enExample) |
| CN (3) | CN1604773A (enExample) |
| AU (1) | AU2002353206B2 (enExample) |
| CA (1) | CA2471046C (enExample) |
| GB (1) | GB0130763D0 (enExample) |
| MX (1) | MXPA04006142A (enExample) |
| PL (1) | PL217404B1 (enExample) |
| RU (1) | RU2332989C2 (enExample) |
| WO (1) | WO2003055474A1 (enExample) |
| ZA (1) | ZA200404813B (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0130763D0 (en) * | 2001-12-21 | 2002-02-06 | Norgine Res Ltd | Treatment methods |
| GB0501580D0 (en) * | 2005-01-25 | 2005-03-02 | Norgine Europe Bv | Compounds for treating urinary incontinence |
| MX2012002759A (es) | 2009-09-04 | 2012-04-30 | Glaxosmithkline Llc | Compuestos quimicos. |
| RU2605290C2 (ru) * | 2011-04-26 | 2016-12-20 | Рдд Фарма Лтд. | Оксиметазолин для лечения аноректальных нарушений |
| CN102976961B (zh) * | 2012-12-24 | 2014-09-24 | 武汉武药制药有限公司 | 盐酸甲氧明的制备方法 |
| US10708086B2 (en) * | 2016-01-19 | 2020-07-07 | National Instruments Corporation | Channel sounding techniques |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1593261A (en) * | 1976-07-23 | 1981-07-15 | Inveresk Res Int | Controlled release suppository |
| JPS60172953A (ja) * | 1984-02-17 | 1985-09-06 | Sagami Chem Res Center | 光学活性β−アミノアルコ−ルの製造方法 |
| FR2647014B1 (fr) * | 1989-05-16 | 1991-08-30 | Paris V Universite | Composition medicamenteuse pour le traitement et la prevention des symptomes de l'insuffisance cardiaque, renfermant un agent alpha-stimulant vasoconstricteur comme principe actif |
| DK339289D0 (da) | 1989-07-07 | 1989-07-07 | Dak Lab As | Farmaceutisk praeparat |
| DK469989D0 (da) * | 1989-09-22 | 1989-09-22 | Bukh Meditec | Farmaceutisk praeparat |
| NL9102142A (nl) * | 1991-12-20 | 1993-07-16 | Dagra Pharma Bv | Zetpillen met vertraagde afgifte en werkwijze voor de bereiding daarvan. |
| EP0946155B2 (en) * | 1996-12-23 | 2009-01-21 | S.L.A. Pharma AG | Pharmaceutical composition for treating fecal incontinence |
| AU6440398A (en) * | 1997-02-26 | 1998-09-18 | Siebel Systems, Inc. | Method of using a cache to determine the visibility to a remote database client of a plurality of database transactions |
| US6539381B1 (en) * | 1999-04-21 | 2003-03-25 | Novell, Inc. | System and method for synchronizing database information |
| GB0028575D0 (en) * | 2000-11-23 | 2001-01-10 | Elan Corp Plc | Oral pharmaceutical compositions containing cyclodextrins |
| US6544927B2 (en) * | 2001-04-28 | 2003-04-08 | University Of Florida | Use of α2-adrenergic receptor agonists and adrenergic inhibitors in reducing defoliation |
| GB0130763D0 (en) * | 2001-12-21 | 2002-02-06 | Norgine Res Ltd | Treatment methods |
| US7089228B2 (en) * | 2002-04-18 | 2006-08-08 | International Business Machines Corporation | Computer apparatus and method for caching results of a database query |
-
2001
- 2001-12-21 GB GBGB0130763.6A patent/GB0130763D0/en not_active Ceased
-
2002
- 2002-12-20 US US10/499,873 patent/US20050096397A1/en not_active Abandoned
- 2002-12-20 RU RU2004122639/15A patent/RU2332989C2/ru not_active IP Right Cessation
- 2002-12-20 EP EP10177730A patent/EP2275099A1/en not_active Withdrawn
- 2002-12-20 PL PL369828A patent/PL217404B1/pl unknown
- 2002-12-20 EP EP02788224A patent/EP1458370A1/en not_active Withdrawn
- 2002-12-20 JP JP2003556052A patent/JP5486143B2/ja not_active Expired - Fee Related
- 2002-12-20 MX MXPA04006142A patent/MXPA04006142A/es active IP Right Grant
- 2002-12-20 CA CA2471046A patent/CA2471046C/en not_active Expired - Fee Related
- 2002-12-20 CN CNA028253248A patent/CN1604773A/zh active Pending
- 2002-12-20 AU AU2002353206A patent/AU2002353206B2/en not_active Ceased
- 2002-12-20 CN CN2011104050612A patent/CN102516101A/zh active Pending
- 2002-12-20 CN CNA2009101594203A patent/CN101601665A/zh active Pending
- 2002-12-20 WO PCT/GB2002/005864 patent/WO2003055474A1/en not_active Ceased
-
2004
- 2004-06-17 ZA ZA2004/04813A patent/ZA200404813B/en unknown
-
2009
- 2009-09-30 US US12/586,973 patent/US8491931B2/en not_active Expired - Fee Related
-
2011
- 2011-02-28 JP JP2011041076A patent/JP2011105770A/ja active Pending
- 2011-11-04 JP JP2011241937A patent/JP5544535B2/ja not_active Expired - Fee Related
-
2012
- 2012-11-15 US US13/678,131 patent/US8613948B2/en not_active Expired - Fee Related
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