JP2005519868A5 - - Google Patents
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- Publication number
- JP2005519868A5 JP2005519868A5 JP2003535721A JP2003535721A JP2005519868A5 JP 2005519868 A5 JP2005519868 A5 JP 2005519868A5 JP 2003535721 A JP2003535721 A JP 2003535721A JP 2003535721 A JP2003535721 A JP 2003535721A JP 2005519868 A5 JP2005519868 A5 JP 2005519868A5
- Authority
- JP
- Japan
- Prior art keywords
- weight
- cream
- sucrose
- docosanol
- therapeutic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000006071 cream Substances 0.000 claims 40
- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 claims 40
- -1 stearic acid ester Chemical class 0.000 claims 34
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims 33
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 33
- 239000000203 mixture Substances 0.000 claims 28
- 230000001225 therapeutic effect Effects 0.000 claims 24
- 229930006000 Sucrose Natural products 0.000 claims 22
- 239000005720 sucrose Substances 0.000 claims 22
- 229940100611 topical cream Drugs 0.000 claims 22
- FOLJTMYCYXSPFQ-CJKAUBRRSA-N [(2r,3s,4s,5r,6r)-6-[(2s,3s,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)-2-(octadecanoyloxymethyl)oxolan-2-yl]oxy-3,4,5-trihydroxyoxan-2-yl]methyl octadecanoate Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](COC(=O)CCCCCCCCCCCCCCCCC)O[C@@H]1O[C@@]1(COC(=O)CCCCCCCCCCCCCCCCC)[C@@H](O)[C@H](O)[C@@H](CO)O1 FOLJTMYCYXSPFQ-CJKAUBRRSA-N 0.000 claims 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 16
- 235000019445 benzyl alcohol Nutrition 0.000 claims 11
- 238000000034 method Methods 0.000 claims 11
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 10
- QIZPVNNYFKFJAD-UHFFFAOYSA-N 1-chloro-2-prop-1-ynylbenzene Chemical compound CC#CC1=CC=CC=C1Cl QIZPVNNYFKFJAD-UHFFFAOYSA-N 0.000 claims 8
- 235000013162 Cocos nucifera Nutrition 0.000 claims 8
- 244000060011 Cocos nucifera Species 0.000 claims 8
- 235000021355 Stearic acid Nutrition 0.000 claims 8
- 235000014113 dietary fatty acids Nutrition 0.000 claims 8
- 239000000194 fatty acid Substances 0.000 claims 8
- 229930195729 fatty acid Natural products 0.000 claims 8
- 150000004665 fatty acids Chemical class 0.000 claims 8
- 229940059904 light mineral oil Drugs 0.000 claims 8
- 239000002480 mineral oil Substances 0.000 claims 8
- 235000010446 mineral oil Nutrition 0.000 claims 8
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims 8
- 239000008117 stearic acid Substances 0.000 claims 8
- 229940035023 sucrose monostearate Drugs 0.000 claims 8
- 206010061218 Inflammation Diseases 0.000 claims 7
- 230000004054 inflammatory process Effects 0.000 claims 7
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 claims 7
- 208000009889 Herpes Simplex Diseases 0.000 claims 6
- 150000002148 esters Chemical class 0.000 claims 6
- 230000000306 recurrent effect Effects 0.000 claims 6
- 239000004094 surface-active agent Substances 0.000 claims 6
- SZYSLWCAWVWFLT-UTGHZIEOSA-N [(2s,3s,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)-2-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxolan-2-yl]methyl octadecanoate Chemical compound O([C@@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@]1(COC(=O)CCCCCCCCCCCCCCCCC)O[C@H](CO)[C@@H](O)[C@@H]1O SZYSLWCAWVWFLT-UTGHZIEOSA-N 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 5
- 239000006184 cosolvent Substances 0.000 claims 5
- 239000003974 emollient agent Substances 0.000 claims 5
- 208000036142 Viral infection Diseases 0.000 claims 4
- 238000009472 formulation Methods 0.000 claims 4
- ULCZGKYHRYJXAU-UHFFFAOYSA-N heptacosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCO ULCZGKYHRYJXAU-UHFFFAOYSA-N 0.000 claims 4
- IRHTZOCLLONTOC-UHFFFAOYSA-N hexacosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCO IRHTZOCLLONTOC-UHFFFAOYSA-N 0.000 claims 4
- CNNRPFQICPFDPO-UHFFFAOYSA-N octacosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCCO CNNRPFQICPFDPO-UHFFFAOYSA-N 0.000 claims 4
- TYWMIZZBOVGFOV-UHFFFAOYSA-N tetracosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCO TYWMIZZBOVGFOV-UHFFFAOYSA-N 0.000 claims 4
- FPLNRAYTBIFSFW-UHFFFAOYSA-N tricosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCCO FPLNRAYTBIFSFW-UHFFFAOYSA-N 0.000 claims 4
- 230000009385 viral infection Effects 0.000 claims 4
- 208000002193 Pain Diseases 0.000 claims 3
- 230000003110 anti-inflammatory effect Effects 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 150000002191 fatty alcohols Chemical class 0.000 claims 3
- 210000004379 membrane Anatomy 0.000 claims 3
- 239000012528 membrane Substances 0.000 claims 3
- AZJXQVRPBZSNFN-UHFFFAOYSA-N octane-3,3-diol Chemical compound CCCCCC(O)(O)CC AZJXQVRPBZSNFN-UHFFFAOYSA-N 0.000 claims 3
- 229960002666 1-octacosanol Drugs 0.000 claims 2
- HBXWUCXDUUJDRB-UHFFFAOYSA-N 1-octadecoxyoctadecane Chemical compound CCCCCCCCCCCCCCCCCCOCCCCCCCCCCCCCCCCCC HBXWUCXDUUJDRB-UHFFFAOYSA-N 0.000 claims 2
- 230000000840 anti-viral effect Effects 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- FIPPFBHCBUDBRR-UHFFFAOYSA-N henicosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCO FIPPFBHCBUDBRR-UHFFFAOYSA-N 0.000 claims 2
- BTFJIXJJCSYFAL-UHFFFAOYSA-N icosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 claims 2
- 208000027866 inflammatory disease Diseases 0.000 claims 2
- 210000004877 mucosa Anatomy 0.000 claims 2
- 210000004400 mucous membrane Anatomy 0.000 claims 2
- 230000003612 virological effect Effects 0.000 claims 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims 1
- DCXXMTOCNZCJGO-UHFFFAOYSA-N Glycerol trioctadecanoate Natural products CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 claims 1
- 206010033474 Pain of skin Diseases 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical class [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 claims 1
- 229960000735 docosanol Drugs 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 1
- RQFLGKYCYMMRMC-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O.CCCCCCCCCCCCCCCCCC(O)=O RQFLGKYCYMMRMC-UHFFFAOYSA-N 0.000 claims 1
- IACKKVBKKNJZGN-UHFFFAOYSA-N pentacosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCO IACKKVBKKNJZGN-UHFFFAOYSA-N 0.000 claims 1
- 150000003445 sucroses Chemical class 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33044401P | 2001-10-16 | 2001-10-16 | |
| PCT/US2002/033019 WO2003032915A2 (en) | 2001-10-16 | 2002-10-15 | Viral inhibition by n-docosanol |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005519868A JP2005519868A (ja) | 2005-07-07 |
| JP2005519868A5 true JP2005519868A5 (enExample) | 2006-01-05 |
Family
ID=23289808
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003535721A Pending JP2005519868A (ja) | 2001-10-16 | 2002-10-15 | ｎ−ドコサノールによるウイルス阻害 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20040033982A1 (enExample) |
| EP (1) | EP1436006A4 (enExample) |
| JP (1) | JP2005519868A (enExample) |
| CN (1) | CN1633306A (enExample) |
| AR (1) | AR036834A1 (enExample) |
| BR (1) | BR0213323A (enExample) |
| CA (1) | CA2421026C (enExample) |
| EA (1) | EA200400535A1 (enExample) |
| HR (1) | HRP20040421B1 (enExample) |
| HU (1) | HUP0402624A3 (enExample) |
| IS (1) | IS7212A (enExample) |
| MX (1) | MXJL04000011A (enExample) |
| NO (1) | NO20041999L (enExample) |
| NZ (1) | NZ532944A (enExample) |
| PL (1) | PL371945A1 (enExample) |
| RU (1) | RU2004115001A (enExample) |
| WO (1) | WO2003032915A2 (enExample) |
| YU (1) | YU31104A (enExample) |
| ZA (1) | ZA200403707B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7754775B2 (en) * | 2004-04-23 | 2010-07-13 | Mercier Michel F | Multi-lamellar liquid crystal emulsion system |
| WO2011112997A1 (en) | 2010-03-11 | 2011-09-15 | Chemic Laboratories, Inc. | Novel compositions and methods |
| US20160089441A1 (en) * | 2014-09-25 | 2016-03-31 | Oralabs, Inc. | Composition for the treatment of cold sores |
| CN107961232B (zh) | 2016-10-20 | 2023-05-26 | 维尔信科技（潍坊）有限公司 | 药物调配物和其用途 |
| EP3897282A4 (en) * | 2018-12-19 | 2022-09-07 | GlaxoSmithKline Consumer Healthcare Holdings (US) LLC | VARIABLE DOSES APPLICATOR |
| US11951082B2 (en) | 2022-08-22 | 2024-04-09 | Ford Therapeutics, Llc | Composition of chlorhexidine |
| WO2024261713A1 (en) | 2023-06-23 | 2024-12-26 | Haleon UK IP Limited | Topical regimen for treating cold sores |
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-
2002
- 2002-10-15 JP JP2003535721A patent/JP2005519868A/ja active Pending
- 2002-10-15 CA CA002421026A patent/CA2421026C/en not_active Expired - Fee Related
- 2002-10-15 RU RU2004115001/15A patent/RU2004115001A/ru not_active Application Discontinuation
- 2002-10-15 YU YU31104A patent/YU31104A/sh unknown
- 2002-10-15 HU HU0402624A patent/HUP0402624A3/hu unknown
- 2002-10-15 HR HRP20040421AA patent/HRP20040421B1/hr not_active IP Right Cessation
- 2002-10-15 PL PL02371945A patent/PL371945A1/xx unknown
- 2002-10-15 US US10/312,321 patent/US20040033982A1/en not_active Abandoned
- 2002-10-15 EA EA200400535A patent/EA200400535A1/ru unknown
- 2002-10-15 EP EP02795523A patent/EP1436006A4/en not_active Withdrawn
- 2002-10-15 BR BR0213323-7A patent/BR0213323A/pt not_active IP Right Cessation
- 2002-10-15 WO PCT/US2002/033019 patent/WO2003032915A2/en not_active Ceased
- 2002-10-15 CN CNA028251695A patent/CN1633306A/zh active Pending
- 2002-10-15 NZ NZ532944A patent/NZ532944A/en not_active IP Right Cessation
- 2002-10-16 AR ARP020103878A patent/AR036834A1/es not_active Application Discontinuation
-
2004
- 2004-04-07 IS IS7212A patent/IS7212A/is unknown
- 2004-04-16 MX MXJL04000011A patent/MXJL04000011A/es unknown
- 2004-05-14 ZA ZA200403707A patent/ZA200403707B/en unknown
- 2004-05-14 NO NO20041999A patent/NO20041999L/no not_active Application Discontinuation
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