JP2005518412A5 - - Google Patents
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- Publication number
- JP2005518412A5 JP2005518412A5 JP2003561609A JP2003561609A JP2005518412A5 JP 2005518412 A5 JP2005518412 A5 JP 2005518412A5 JP 2003561609 A JP2003561609 A JP 2003561609A JP 2003561609 A JP2003561609 A JP 2003561609A JP 2005518412 A5 JP2005518412 A5 JP 2005518412A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- estrogen deficiency
- composition according
- tibolone
- synthesis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010030247 Oestrogen deficiency Diseases 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 5
- 229940122815 Aromatase inhibitor Drugs 0.000 claims 4
- 239000003886 aromatase inhibitor Substances 0.000 claims 4
- 230000015572 biosynthetic process Effects 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 4
- 229940011871 estrogen Drugs 0.000 claims 4
- 239000000262 estrogen Substances 0.000 claims 4
- 238000003786 synthesis reaction Methods 0.000 claims 4
- WZDGZWOAQTVYBX-XOINTXKNSA-N tibolone Chemical compound C([C@@H]12)C[C@]3(C)[C@@](C#C)(O)CC[C@H]3[C@@H]1[C@H](C)CC1=C2CCC(=O)C1 WZDGZWOAQTVYBX-XOINTXKNSA-N 0.000 claims 4
- 229960001023 tibolone Drugs 0.000 claims 4
- BFYIZQONLCFLEV-DAELLWKTSA-N Aromasine Chemical compound O=C1C=C[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CC(=C)C2=C1 BFYIZQONLCFLEV-DAELLWKTSA-N 0.000 claims 2
- 208000001132 Osteoporosis Diseases 0.000 claims 2
- 229960003437 aminoglutethimide Drugs 0.000 claims 2
- ROBVIMPUHSLWNV-UHFFFAOYSA-N aminoglutethimide Chemical group C=1C=C(N)C=CC=1C1(CC)CCC(=O)NC1=O ROBVIMPUHSLWNV-UHFFFAOYSA-N 0.000 claims 2
- 229960002932 anastrozole Drugs 0.000 claims 2
- YBBLVLTVTVSKRW-UHFFFAOYSA-N anastrozole Chemical compound N#CC(C)(C)C1=CC(C(C)(C#N)C)=CC(CN2N=CN=C2)=C1 YBBLVLTVTVSKRW-UHFFFAOYSA-N 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 229960000255 exemestane Drugs 0.000 claims 2
- 229960004421 formestane Drugs 0.000 claims 2
- OSVMTWJCGUFAOD-KZQROQTASA-N formestane Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1O OSVMTWJCGUFAOD-KZQROQTASA-N 0.000 claims 2
- 229960003881 letrozole Drugs 0.000 claims 2
- HPJKCIUCZWXJDR-UHFFFAOYSA-N letrozole Chemical compound C1=CC(C#N)=CC=C1C(N1N=CN=C1)C1=CC=C(C#N)C=C1 HPJKCIUCZWXJDR-UHFFFAOYSA-N 0.000 claims 2
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 claims 1
- 229960005309 estradiol Drugs 0.000 claims 1
- 229930182833 estradiol Natural products 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02075235 | 2002-01-22 | ||
| PCT/EP2003/000373 WO2003061665A1 (en) | 2002-01-22 | 2003-01-16 | Tibolone in the treatment of complaints associated with the administration of drugs which prevent the synthesis of endogenous estrogen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005518412A JP2005518412A (ja) | 2005-06-23 |
| JP2005518412A5 true JP2005518412A5 (https=) | 2006-03-16 |
Family
ID=27589110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003561609A Pending JP2005518412A (ja) | 2002-01-22 | 2003-01-16 | 内因性エストロゲンの合成を阻害する薬物の投与に伴う愁訴の治療におけるチボロン |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20050124592A1 (https=) |
| EP (1) | EP1469861A1 (https=) |
| JP (1) | JP2005518412A (https=) |
| KR (1) | KR20040073572A (https=) |
| CN (1) | CN1620298A (https=) |
| BR (1) | BR0306789A (https=) |
| CA (1) | CA2472240A1 (https=) |
| EC (1) | ECSP045179A (https=) |
| HR (1) | HRP20040635A2 (https=) |
| IL (1) | IL162769A0 (https=) |
| IS (1) | IS7338A (https=) |
| MX (1) | MXPA04007071A (https=) |
| PL (1) | PL371181A1 (https=) |
| RU (1) | RU2004125594A (https=) |
| WO (1) | WO2003061665A1 (https=) |
| ZA (1) | ZA200405262B (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0302572D0 (en) | 2003-02-05 | 2003-03-12 | Astrazeneca Ab | Method of treatment |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE63051B1 (en) * | 1989-03-18 | 1995-03-22 | Akzo Nv | Pharmaceutical composition which contains a pharmaceutically suitable carrier and the compound having the structure (7alpha, 17alpha)-17-Hydroxy-7-methyl-19-nor-17-pregn-5(10)-en-20-yn- 3-one |
| ES2134313T3 (es) * | 1993-03-05 | 1999-10-01 | Akzo Nobel Nv | Utilizacion de derivados de pregnano para el tratamiento de tumores. |
| EP1102755B1 (en) * | 1998-08-07 | 2006-01-04 | Chiron Corporation | Substituted isoxazole derivatives as estrogen receptor modulators |
-
2003
- 2003-01-16 JP JP2003561609A patent/JP2005518412A/ja active Pending
- 2003-01-16 CN CNA038025108A patent/CN1620298A/zh active Pending
- 2003-01-16 US US10/502,444 patent/US20050124592A1/en not_active Abandoned
- 2003-01-16 BR BR0306789-0A patent/BR0306789A/pt not_active IP Right Cessation
- 2003-01-16 PL PL03371181A patent/PL371181A1/xx not_active Application Discontinuation
- 2003-01-16 KR KR10-2004-7011160A patent/KR20040073572A/ko not_active Withdrawn
- 2003-01-16 IL IL16276903A patent/IL162769A0/xx unknown
- 2003-01-16 RU RU2004125594/14A patent/RU2004125594A/ru not_active Application Discontinuation
- 2003-01-16 HR HR20040635A patent/HRP20040635A2/hr not_active Application Discontinuation
- 2003-01-16 EP EP20030731620 patent/EP1469861A1/en not_active Withdrawn
- 2003-01-16 MX MXPA04007071A patent/MXPA04007071A/es not_active Application Discontinuation
- 2003-01-16 WO PCT/EP2003/000373 patent/WO2003061665A1/en not_active Ceased
- 2003-01-16 CA CA002472240A patent/CA2472240A1/en not_active Abandoned
-
2004
- 2004-06-28 IS IS7338A patent/IS7338A/is unknown
- 2004-07-01 ZA ZA2004/05262A patent/ZA200405262B/en unknown
- 2004-07-06 EC EC2004005179A patent/ECSP045179A/es unknown
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