JP2021502392A5 - - Google Patents
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- Publication number
- JP2021502392A5 JP2021502392A5 JP2020526149A JP2020526149A JP2021502392A5 JP 2021502392 A5 JP2021502392 A5 JP 2021502392A5 JP 2020526149 A JP2020526149 A JP 2020526149A JP 2020526149 A JP2020526149 A JP 2020526149A JP 2021502392 A5 JP2021502392 A5 JP 2021502392A5
- Authority
- JP
- Japan
- Prior art keywords
- ataxia
- medicament according
- patient
- administered
- riluzole prodrug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010003591 Ataxia Diseases 0.000 claims description 57
- 239000000651 prodrug Substances 0.000 claims description 27
- 229940002612 prodrug Drugs 0.000 claims description 27
- FTALBRSUTCGOEG-UHFFFAOYSA-N Riluzole Chemical compound C1=C(OC(F)(F)F)C=C2SC(N)=NC2=C1 FTALBRSUTCGOEG-UHFFFAOYSA-N 0.000 claims description 25
- 229960004181 riluzole Drugs 0.000 claims description 25
- 239000003814 drug Substances 0.000 claims description 21
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 6
- 208000009415 Spinocerebellar Ataxias Diseases 0.000 claims description 6
- 230000004424 eye movement Effects 0.000 claims description 6
- 208000024412 Friedreich ataxia Diseases 0.000 claims description 5
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- 206010008025 Cerebellar ataxia Diseases 0.000 claims description 4
- 208000002569 Machado-Joseph Disease Diseases 0.000 claims description 4
- 208000036834 Spinocerebellar ataxia type 3 Diseases 0.000 claims description 4
- 108091023045 Untranslated Region Proteins 0.000 claims description 4
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims description 4
- 230000035772 mutation Effects 0.000 claims description 4
- 102000014461 Ataxins Human genes 0.000 claims description 3
- 108010078286 Ataxins Proteins 0.000 claims description 3
- 229930003427 Vitamin E Natural products 0.000 claims description 3
- 201000004562 autosomal dominant cerebellar ataxia Diseases 0.000 claims description 3
- 230000007812 deficiency Effects 0.000 claims description 3
- 230000003205 diastolic effect Effects 0.000 claims description 3
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 3
- 201000001119 neuropathy Diseases 0.000 claims description 3
- 230000007823 neuropathy Effects 0.000 claims description 3
- 208000033808 peripheral neuropathy Diseases 0.000 claims description 3
- 229940046009 vitamin E Drugs 0.000 claims description 3
- 235000019165 vitamin E Nutrition 0.000 claims description 3
- 239000011709 vitamin E Substances 0.000 claims description 3
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims description 2
- 102000007372 Ataxin-1 Human genes 0.000 claims description 2
- 108010032963 Ataxin-1 Proteins 0.000 claims description 2
- 208000001089 Multiple system atrophy Diseases 0.000 claims description 2
- 239000002775 capsule Substances 0.000 claims description 2
- 125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 2
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Substances C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 2
- 201000003624 spinocerebellar ataxia type 1 Diseases 0.000 claims description 2
- 239000002552 dosage form Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 241000255925 Diptera Species 0.000 claims 1
- 150000003536 tetrazoles Chemical class 0.000 claims 1
- 238000000034 method Methods 0.000 description 22
- 102000007371 Ataxin-3 Human genes 0.000 description 3
- 206010050389 Cerebral ataxia Diseases 0.000 description 2
- 206010039509 Scab Diseases 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 1
- 208000005587 Refsum Disease Diseases 0.000 description 1
- 208000010112 Spinocerebellar Degenerations Diseases 0.000 description 1
- 208000004622 abetalipoproteinemia Diseases 0.000 description 1
- 208000030597 adult Refsum disease Diseases 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 238000002648 combination therapy Methods 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 201000003636 hereditary ataxia Diseases 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023149803A JP2023175823A (ja) | 2017-11-12 | 2023-09-15 | 運動失調を処置するためのリルゾールプロドラッグの使用 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762584856P | 2017-11-12 | 2017-11-12 | |
| US62/584,856 | 2017-11-12 | ||
| US201862717948P | 2018-08-13 | 2018-08-13 | |
| US62/717,948 | 2018-08-13 | ||
| PCT/US2018/060232 WO2019094851A1 (en) | 2017-11-12 | 2018-11-11 | Use of riluzole prodrugs to treat ataxias |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023149803A Division JP2023175823A (ja) | 2017-11-12 | 2023-09-15 | 運動失調を処置するためのリルゾールプロドラッグの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021502392A JP2021502392A (ja) | 2021-01-28 |
| JP2021502392A5 true JP2021502392A5 (https=) | 2021-10-21 |
| JP7352542B2 JP7352542B2 (ja) | 2023-09-28 |
Family
ID=66438598
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020526149A Active JP7352542B2 (ja) | 2017-11-12 | 2018-11-11 | 運動失調を処置するためのリルゾールプロドラッグの使用 |
| JP2023149803A Pending JP2023175823A (ja) | 2017-11-12 | 2023-09-15 | 運動失調を処置するためのリルゾールプロドラッグの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023149803A Pending JP2023175823A (ja) | 2017-11-12 | 2023-09-15 | 運動失調を処置するためのリルゾールプロドラッグの使用 |
Country Status (26)
| Country | Link |
|---|---|
| US (3) | US20210023061A1 (https=) |
| EP (4) | EP4483956B1 (https=) |
| JP (2) | JP7352542B2 (https=) |
| KR (2) | KR20200103658A (https=) |
| CN (1) | CN112292127A (https=) |
| AU (1) | AU2018364749C1 (https=) |
| BR (1) | BR112020009173A2 (https=) |
| CA (1) | CA3082096A1 (https=) |
| DK (2) | DK3706739T3 (https=) |
| ES (1) | ES2996892T3 (https=) |
| FI (2) | FI3706739T3 (https=) |
| HR (1) | HRP20241675T1 (https=) |
| HU (1) | HUE070302T2 (https=) |
| IL (1) | IL274532B2 (https=) |
| LT (2) | LT3706739T (https=) |
| MD (1) | MD3706739T2 (https=) |
| MX (2) | MX2020004678A (https=) |
| PH (1) | PH12020550583A1 (https=) |
| PL (1) | PL3706739T3 (https=) |
| PT (2) | PT3706739T (https=) |
| RS (1) | RS66277B1 (https=) |
| SG (1) | SG11202004332XA (https=) |
| SI (1) | SI3706739T1 (https=) |
| SM (1) | SMT202500022T1 (https=) |
| WO (1) | WO2019094851A1 (https=) |
| ZA (1) | ZA202002626B (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016140879A1 (en) | 2015-03-03 | 2016-09-09 | Biohaven Pharmaceutical Holding Company Ltd. | Riluzole prodrugs and their use |
| US12295942B2 (en) | 2015-03-03 | 2025-05-13 | Biohaven Therapeutics Ltd. | Riluzole prodrugs and their use |
| WO2018031707A1 (en) | 2016-08-10 | 2018-02-15 | Biohaven Pharmaceutical Holding Company Ltd. | Acyl benzo[d]thiazol-2-amine and their methods of use |
| EP4277624B1 (en) * | 2021-01-18 | 2026-01-14 | Biohaven Therapeutics Ltd. | Troriluzole for use in the treatment of alzheimer's disease of mild severity |
| US20250127789A1 (en) * | 2021-11-04 | 2025-04-24 | Skyhawk Therapeutics, Inc. | Compositions useful for modulating splicing |
| WO2023230451A2 (en) * | 2022-05-23 | 2023-11-30 | Biohaven Therapeutics Ltd. | Methods of treating spinocerebellar ataxias |
| WO2026078657A1 (en) | 2024-10-10 | 2026-04-16 | Biohaven Therapeutics Ltd. | Prodrugs of riluzole |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1548022A (en) | 1976-10-06 | 1979-07-04 | Wyeth John & Brother Ltd | Pharmaceutial dosage forms |
| ATE208615T1 (de) | 1993-07-09 | 2001-11-15 | Scherer Corp R P | Verfahren zur herstellung von gefriergetrockneten arzneistoffdosierungsformen |
| US5457895A (en) | 1993-10-01 | 1995-10-17 | R. P. Scherer Corporation | Method of identifying freeze-dried dosage forms |
| US5837287A (en) | 1994-10-28 | 1998-11-17 | R P Scherer Corporation | Process for preparing solid pharmaceutical dosage forms |
| WO1998036738A1 (en) | 1997-02-20 | 1998-08-27 | Therics, Inc. | Dosage form exhibiting rapid disperse properties, methods of use and process for the manufacture of same |
| PT1001748E (pt) | 1997-07-25 | 2006-08-31 | Alpex Pharma Sa | Um processo para a preparacao de um granulado adequado para a preparacao de comprimidos rapidamente desintegraveis na boca |
| FR2774592B1 (fr) * | 1998-02-06 | 2000-03-17 | Rhone Poulenc Rorer Sa | Application du 2-amino-6-trifluoromethoxybenzothiazole pour la prevention ou le traitement des dysfonctionnements du cervelet |
| IL143197A0 (en) | 1998-11-20 | 2002-04-21 | Rtp Pharma Inc | Dispersible phospholipid stabilized microparticles |
| GB9908014D0 (en) | 1999-04-08 | 1999-06-02 | Scherer Corp R P | Pharmaceutical compositions |
| US6284270B1 (en) | 1999-08-04 | 2001-09-04 | Drugtech Corporation | Means for creating a mass having structural integrity |
| US6316029B1 (en) | 2000-05-18 | 2001-11-13 | Flak Pharma International, Ltd. | Rapidly disintegrating solid oral dosage form |
| US6982251B2 (en) | 2000-12-20 | 2006-01-03 | Schering Corporation | Substituted 2-azetidinones useful as hypocholesterolemic agents |
| US6814978B2 (en) | 2000-12-29 | 2004-11-09 | Mcneil-Ppc, Inc. | Process for preparing a soft tablet |
| US6509040B1 (en) | 2001-06-22 | 2003-01-21 | R.P. Scherer Corporation | Fast dispersing dosage forms essentially free of mammalian gelatin |
| ES2292848T3 (es) | 2001-10-12 | 2008-03-16 | Elan Pharma International Limited | Composiciones que tienen una combinacion de caracteristicas de liberacion inmediata y liberacion controlada. |
| AU2003211051A1 (en) | 2002-02-13 | 2003-09-04 | Michael K. Weibel | Drug dose-form and method of manufacture |
| ATE337003T1 (de) * | 2003-04-28 | 2006-09-15 | Biofrontera Bioscience Gmbh | Verwendung von riluzole kombiniert mit geeigneten hilfs-und zusatzstoffen zur behandlung von krankheiten, die durch eine hyperproliferation von keratinozyten gekennzeichnet sind, insbesondere neurodermitis und psoriasis |
| US7282217B1 (en) | 2003-08-29 | 2007-10-16 | Kv Pharmaceutical Company | Rapidly disintegrable tablets |
| US8158152B2 (en) | 2005-11-18 | 2012-04-17 | Scidose Llc | Lyophilization process and products obtained thereby |
| BRPI0620578A2 (pt) | 2005-12-27 | 2011-12-06 | Jubilant Organosys Ltd | composição farmacêutica que dissolve na boca e processo para o preparo da mesma |
| EP2170282A4 (en) | 2007-06-27 | 2014-11-05 | Hanmi Pharm Ind Co Ltd | METHOD FOR PRODUCING A QUICKLY CRUSHING FORMULATION FOR ORAL ADMINISTRATION AND DEVICE FOR PREPARING AND PACKAGING THE FORMULATION |
| WO2009146031A1 (en) * | 2008-03-31 | 2009-12-03 | University Of South Florida | Methods of treating disease-induced ataxia and non-ataxic imbalance |
| US8414356B2 (en) | 2008-10-31 | 2013-04-09 | The Invention Science Fund I, Llc | Systems, devices, and methods for making or administering frozen particles |
| US8613937B2 (en) | 2008-10-31 | 2013-12-24 | The Invention Science Fund I, Llc | Compositions and methods for biological remodeling with frozen particle compositions |
| US8313768B2 (en) | 2009-09-24 | 2012-11-20 | Mcneil-Ppc, Inc. | Manufacture of tablet having immediate release region and sustained release region |
| WO2016140879A1 (en) * | 2015-03-03 | 2016-09-09 | Biohaven Pharmaceutical Holding Company Ltd. | Riluzole prodrugs and their use |
-
2018
- 2018-11-11 EP EP24199849.1A patent/EP4483956B1/en active Active
- 2018-11-11 IL IL274532A patent/IL274532B2/en unknown
- 2018-11-11 MD MDE20200953T patent/MD3706739T2/ro unknown
- 2018-11-11 PL PL18876779.2T patent/PL3706739T3/pl unknown
- 2018-11-11 EP EP25216894.3A patent/EP4696324A3/en active Pending
- 2018-11-11 KR KR1020207016775A patent/KR20200103658A/ko not_active Ceased
- 2018-11-11 EP EP25216909.9A patent/EP4699619A3/en active Pending
- 2018-11-11 DK DK18876779.2T patent/DK3706739T3/da active
- 2018-11-11 LT LTEPPCT/US2018/060232T patent/LT3706739T/lt unknown
- 2018-11-11 DK DK24199849.1T patent/DK4483956T3/da active
- 2018-11-11 CN CN201880073828.6A patent/CN112292127A/zh active Pending
- 2018-11-11 MX MX2020004678A patent/MX2020004678A/es unknown
- 2018-11-11 BR BR112020009173-1A patent/BR112020009173A2/pt not_active Application Discontinuation
- 2018-11-11 HR HRP20241675TT patent/HRP20241675T1/hr unknown
- 2018-11-11 AU AU2018364749A patent/AU2018364749C1/en active Active
- 2018-11-11 SM SM20250022T patent/SMT202500022T1/it unknown
- 2018-11-11 US US16/762,165 patent/US20210023061A1/en active Pending
- 2018-11-11 SI SI201831180T patent/SI3706739T1/sl unknown
- 2018-11-11 LT LTEP24199849.1T patent/LT4483956T/lt unknown
- 2018-11-11 WO PCT/US2018/060232 patent/WO2019094851A1/en not_active Ceased
- 2018-11-11 FI FIEP18876779.2T patent/FI3706739T3/fi active
- 2018-11-11 PT PT188767792T patent/PT3706739T/pt unknown
- 2018-11-11 CA CA3082096A patent/CA3082096A1/en active Pending
- 2018-11-11 KR KR1020257006278A patent/KR20250034521A/ko active Pending
- 2018-11-11 PT PT241998491T patent/PT4483956T/pt unknown
- 2018-11-11 FI FIEP24199849.1T patent/FI4483956T3/fi active
- 2018-11-11 RS RS20241371A patent/RS66277B1/sr unknown
- 2018-11-11 SG SG11202004332XA patent/SG11202004332XA/en unknown
- 2018-11-11 ES ES18876779T patent/ES2996892T3/es active Active
- 2018-11-11 JP JP2020526149A patent/JP7352542B2/ja active Active
- 2018-11-11 HU HUE18876779A patent/HUE070302T2/hu unknown
- 2018-11-11 EP EP18876779.2A patent/EP3706739B1/en active Active
-
2020
- 2020-05-08 PH PH12020550583A patent/PH12020550583A1/en unknown
- 2020-05-11 ZA ZA2020/02626A patent/ZA202002626B/en unknown
- 2020-07-13 MX MX2023012640A patent/MX2023012640A/es unknown
-
2023
- 2023-07-17 US US18/353,840 patent/US12102618B2/en active Active
- 2023-07-17 US US18/353,850 patent/US20230355592A1/en active Pending
- 2023-09-15 JP JP2023149803A patent/JP2023175823A/ja active Pending
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