JP2005516616A5 - - Google Patents
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- JP2005516616A5 JP2005516616A5 JP2003566191A JP2003566191A JP2005516616A5 JP 2005516616 A5 JP2005516616 A5 JP 2005516616A5 JP 2003566191 A JP2003566191 A JP 2003566191A JP 2003566191 A JP2003566191 A JP 2003566191A JP 2005516616 A5 JP2005516616 A5 JP 2005516616A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- stem cell
- lineage
- stem
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000000130 stem cell Anatomy 0.000 claims 35
- 210000004027 cell Anatomy 0.000 claims 27
- 238000000034 method Methods 0.000 claims 14
- 239000000126 substance Substances 0.000 claims 12
- 238000012258 culturing Methods 0.000 claims 11
- 108090000623 proteins and genes Proteins 0.000 claims 10
- 150000001875 compounds Chemical class 0.000 claims 6
- 241000124008 Mammalia Species 0.000 claims 5
- 230000012010 growth Effects 0.000 claims 5
- 239000003102 growth factor Substances 0.000 claims 5
- 210000001519 tissue Anatomy 0.000 claims 5
- 239000000427 antigen Substances 0.000 claims 4
- 102000036639 antigens Human genes 0.000 claims 4
- 108091007433 antigens Proteins 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 4
- 108020004999 messenger RNA Proteins 0.000 claims 4
- 230000005856 abnormality Effects 0.000 claims 3
- 210000002986 dental sac Anatomy 0.000 claims 3
- 230000004064 dysfunction Effects 0.000 claims 3
- 239000011159 matrix material Substances 0.000 claims 3
- 239000012528 membrane Substances 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 238000002054 transplantation Methods 0.000 claims 3
- 229920002988 biodegradable polymer Polymers 0.000 claims 2
- 239000004621 biodegradable polymer Substances 0.000 claims 2
- 210000004204 blood vessel Anatomy 0.000 claims 2
- 210000000988 bone and bone Anatomy 0.000 claims 2
- 230000001413 cellular effect Effects 0.000 claims 2
- 230000004069 differentiation Effects 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 210000003981 ectoderm Anatomy 0.000 claims 2
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 claims 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 2
- 239000003550 marker Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 238000010998 test method Methods 0.000 claims 2
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 claims 2
- 230000017423 tissue regeneration Effects 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- APIXJSLKIYYUKG-UHFFFAOYSA-N 3 Isobutyl 1 methylxanthine Chemical compound O=C1N(C)C(=O)N(CC(C)C)C2=C1N=CN2 APIXJSLKIYYUKG-UHFFFAOYSA-N 0.000 claims 1
- 102000007350 Bone Morphogenetic Proteins Human genes 0.000 claims 1
- 108010007726 Bone Morphogenetic Proteins Proteins 0.000 claims 1
- 102000000905 Cadherin Human genes 0.000 claims 1
- 108050007957 Cadherin Proteins 0.000 claims 1
- 102000009024 Epidermal Growth Factor Human genes 0.000 claims 1
- 101800003838 Epidermal growth factor Proteins 0.000 claims 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 claims 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 claims 1
- 102000018233 Fibroblast Growth Factor Human genes 0.000 claims 1
- 108050007372 Fibroblast Growth Factor Proteins 0.000 claims 1
- 102000003745 Hepatocyte Growth Factor Human genes 0.000 claims 1
- 108090000100 Hepatocyte Growth Factor Proteins 0.000 claims 1
- 102000004877 Insulin Human genes 0.000 claims 1
- 108090001061 Insulin Proteins 0.000 claims 1
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims 1
- 102000014150 Interferons Human genes 0.000 claims 1
- 108010050904 Interferons Proteins 0.000 claims 1
- 102000015696 Interleukins Human genes 0.000 claims 1
- 108010063738 Interleukins Proteins 0.000 claims 1
- 108010025020 Nerve Growth Factor Proteins 0.000 claims 1
- 102000007072 Nerve Growth Factors Human genes 0.000 claims 1
- 108010038512 Platelet-Derived Growth Factor Proteins 0.000 claims 1
- 102000010780 Platelet-Derived Growth Factor Human genes 0.000 claims 1
- 102000013275 Somatomedins Human genes 0.000 claims 1
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 1
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 1
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims 1
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 1
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 1
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 claims 1
- 210000001367 artery Anatomy 0.000 claims 1
- 210000002805 bone matrix Anatomy 0.000 claims 1
- 229940112869 bone morphogenetic protein Drugs 0.000 claims 1
- 230000010261 cell growth Effects 0.000 claims 1
- 230000003021 clonogenic effect Effects 0.000 claims 1
- 210000002808 connective tissue Anatomy 0.000 claims 1
- 210000004748 cultured cell Anatomy 0.000 claims 1
- 238000007865 diluting Methods 0.000 claims 1
- 210000001900 endoderm Anatomy 0.000 claims 1
- 210000002889 endothelial cell Anatomy 0.000 claims 1
- 229940116977 epidermal growth factor Drugs 0.000 claims 1
- 210000002744 extracellular matrix Anatomy 0.000 claims 1
- 210000003195 fascia Anatomy 0.000 claims 1
- 229940126864 fibroblast growth factor Drugs 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 229960000905 indomethacin Drugs 0.000 claims 1
- 229940125396 insulin Drugs 0.000 claims 1
- 102000006495 integrins Human genes 0.000 claims 1
- 108010044426 integrins Proteins 0.000 claims 1
- 229940079322 interferon Drugs 0.000 claims 1
- 210000003041 ligament Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 1
- 210000005033 mesothelial cell Anatomy 0.000 claims 1
- 230000001537 neural effect Effects 0.000 claims 1
- 230000003239 periodontal effect Effects 0.000 claims 1
- 201000001245 periodontitis Diseases 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 229930002330 retinoic acid Natural products 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 229920001059 synthetic polymer Polymers 0.000 claims 1
- 210000002435 tendon Anatomy 0.000 claims 1
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 1
- 229960000278 theophylline Drugs 0.000 claims 1
- 210000004357 third molar Anatomy 0.000 claims 1
- 229960001727 tretinoin Drugs 0.000 claims 1
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 claims 1
- 210000003462 vein Anatomy 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35415202P | 2002-02-06 | 2002-02-06 | |
| PCT/EP2003/001131 WO2003066840A2 (en) | 2002-02-06 | 2003-02-05 | Pluripotent embryonic-like stem cells derived from teeth and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005516616A JP2005516616A (ja) | 2005-06-09 |
| JP2005516616A5 true JP2005516616A5 (https=) | 2005-12-22 |
| JP4125241B2 JP4125241B2 (ja) | 2008-07-30 |
Family
ID=27734324
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003566191A Expired - Fee Related JP4125241B2 (ja) | 2002-02-06 | 2003-02-05 | 歯に由来する多能性胚性様幹細胞およびその使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20050106724A1 (https=) |
| EP (1) | EP1456357B1 (https=) |
| JP (1) | JP4125241B2 (https=) |
| AT (1) | ATE397654T1 (https=) |
| AU (1) | AU2003206844B2 (https=) |
| CA (1) | CA2474783A1 (https=) |
| DE (1) | DE60321440D1 (https=) |
| NZ (1) | NZ534540A (https=) |
| WO (1) | WO2003066840A2 (https=) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2416801C (en) * | 2000-07-21 | 2012-01-03 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Adult human dental pulp stem cells in vitro and in vivo |
| AU2003231015B2 (en) | 2003-04-19 | 2009-10-08 | Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services National Institutes Of Health | Postnatal stem cells and uses thereof |
| US20050147960A1 (en) * | 2003-10-10 | 2005-07-07 | Douglas Levinson | In vitro development of tissues and organs |
| BRPI0402659A (pt) * | 2004-06-23 | 2006-01-31 | Univ Fed Sao Paulo Unifesp | Uso de células tronco, método de engenharia tecidual, usos de tecidos dentais e substituto biológico do dente |
| JP4831687B2 (ja) * | 2004-07-23 | 2011-12-07 | 株式会社カネカ | 間葉系幹細胞から象牙芽細胞への分化誘導方法 |
| EP1796693A2 (en) * | 2004-08-26 | 2007-06-20 | Chandrashekhar P. Pathak | Implantable tissue compositions and method |
| JP4734669B2 (ja) * | 2005-02-04 | 2011-07-27 | 独立行政法人産業技術総合研究所 | ヒト歯乳頭からの幹細胞及びその利用方法 |
| EP1705245B1 (en) * | 2005-03-23 | 2009-05-20 | Stiftung CAESAR | Neural stem cells |
| US20070258957A1 (en) * | 2006-05-04 | 2007-11-08 | Russell Bowermaster | Method for obtaining and storing multipotent stem cells |
| DE602005012081D1 (de) * | 2005-07-29 | 2009-02-12 | Univ Bonn | Verfahren zur Isolierung von Stammzellen aus ein kissenformiges Gewebe der Zähne |
| JP4781037B2 (ja) * | 2005-08-01 | 2011-09-28 | 株式会社カネカ | ヒト歯髄細胞の判別及び選択方法 |
| EP1780265A1 (en) * | 2005-10-25 | 2007-05-02 | Stiftung CAESAR | Differentiation of stem cells into chondrocytes |
| US7448871B2 (en) * | 2005-12-09 | 2008-11-11 | Krasner Paul R | Apparatus and method for storing and transporting teeth |
| ITNA20060017A1 (it) * | 2006-02-20 | 2007-08-21 | Aquino Riccardo D | Tecnica di prelievo e selezione di un una popolazione di cellule staminali di tipo embrionale da tessuti follicolari peridentari di uomo adulto. |
| WO2008011524A2 (en) | 2006-07-20 | 2008-01-24 | Richard Burt | Method of using mitotically inactivated stem cells for damaged tissue repair |
| WO2008031451A1 (en) * | 2006-09-11 | 2008-03-20 | Institut Für Molekulare Diagnostik Und Innovative Therapie - Molthera - Gmbh | A post-natal periodontal-derived neural stem cell |
| DE102007005946A1 (de) | 2007-02-01 | 2008-08-14 | Stiftung Caesar | Therapeutische Zusammensetzung und Verwendung einer zellfreien Substanz |
| US20100285582A1 (en) * | 2007-10-01 | 2010-11-11 | Seoul National University Industry Foundation | Various human dental stem cells having a mineralization ability and the method for culturing them |
| KR101212548B1 (ko) | 2007-10-01 | 2012-12-14 | 재단법인서울대학교산학협력재단 | 새로운 치소낭 유래의 치아 줄기세포 및 그의 배양 방법 |
| ITRM20080342A1 (it) * | 2008-06-26 | 2009-12-27 | Univ Degli Studi Udine | Cellule di polpa dentale midollo-simili, metodi per isolamento ed uso. |
| US10328103B2 (en) | 2009-01-03 | 2019-06-25 | Ray C. Wasielewski | Medical treatment composition comprising mammalian dental pulp stem cells |
| US8470308B2 (en) * | 2009-01-03 | 2013-06-25 | Ray C. Wasielewski | Enhanced medical implant comprising disrupted tooth pulp and tooth particles |
| CN102341696B (zh) * | 2009-03-03 | 2013-12-11 | 万迈医疗仪器有限公司 | 用于高灵敏度荧光分析的检测系统和方法 |
| CN102686720B (zh) * | 2009-11-17 | 2013-12-04 | 国立大学法人冈山大学 | 由牙髓细胞向成牙本质细胞的分化诱导方法 |
| US9352003B1 (en) | 2010-05-14 | 2016-05-31 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| US8883210B1 (en) | 2010-05-14 | 2014-11-11 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| US10130736B1 (en) | 2010-05-14 | 2018-11-20 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| US8834928B1 (en) | 2011-05-16 | 2014-09-16 | Musculoskeletal Transplant Foundation | Tissue-derived tissugenic implants, and methods of fabricating and using same |
| EP2633870B1 (en) | 2012-02-29 | 2018-08-01 | Technische Universität Berlin | Method of preparing an artificial tooth primordium in vitro and artificial tooth primordium derived therefrom |
| SG11201405875PA (en) | 2012-03-19 | 2014-11-27 | Richard Burt | Methods and compositions for regenerating and repairing damaged tissue using nonviable irradiated or lyophilized pluripotent stem cells |
| WO2013146992A1 (ja) | 2012-03-29 | 2013-10-03 | 日本ケミカルリサーチ株式会社 | 歯髄由来の多能性幹細胞の製造方法 |
| US9790468B2 (en) | 2013-03-15 | 2017-10-17 | Avita Iinternational Ltd. | Multifunctional immature dental pulp stem cells and therapeutic applications |
| CA2986702C (en) | 2015-05-21 | 2023-04-04 | David Wang | Modified demineralized cortical bone fibers |
| US10813955B2 (en) | 2015-09-29 | 2020-10-27 | Genani Corporation | Methods for treating age-related organ or tissue dysfunction through heterochronic transbiosis using nonviable pluripotent stem cells |
| IT201700025741A1 (it) * | 2017-03-08 | 2018-09-08 | Univ Degli Studi G Dannunzio Chieti Pescara | Saggi farmacologici per la fibrosi cistica |
| CN108165465A (zh) * | 2018-03-27 | 2018-06-15 | 成都曌昊科技有限公司 | 一种用于牙齿中获取干细胞的采集处理试剂盒 |
| KR20210041578A (ko) | 2018-07-31 | 2021-04-15 | 제이씨알 파마 가부시키가이샤 | 치수 유래 세포의 제조 방법 |
| EP4098267A4 (en) | 2020-01-30 | 2024-03-06 | JCR Pharmaceuticals Co., Ltd. | MEDICINAL COMPOSITION COMPRISING CELLS DERIVED FROM DENTAL PULP |
| KR102819184B1 (ko) * | 2022-05-26 | 2025-06-13 | 주식회사 셀진 | 하이드로겔 및 줄기세포 스페로이드를 포함하는 골 재생용 조성물 및 이의 용도 |
| CN119523919B (zh) * | 2025-01-22 | 2025-04-15 | 成都世联康健生物科技有限公司 | 一种冻存牙囊间充质干细胞注射液及其制备方法和应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5843780A (en) * | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| US5885829A (en) * | 1996-05-28 | 1999-03-23 | The Regents Of The University Of Michigan | Engineering oral tissues |
| WO2001021767A2 (en) * | 1999-09-24 | 2001-03-29 | Morphogen Pharmaceuticals, Inc. | Pluripotent embryonic-like stem cells, compositions, methods and uses thereof |
| CA2416801C (en) | 2000-07-21 | 2012-01-03 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Adult human dental pulp stem cells in vitro and in vivo |
-
2003
- 2003-02-05 AU AU2003206844A patent/AU2003206844B2/en not_active Ceased
- 2003-02-05 WO PCT/EP2003/001131 patent/WO2003066840A2/en not_active Ceased
- 2003-02-05 JP JP2003566191A patent/JP4125241B2/ja not_active Expired - Fee Related
- 2003-02-05 CA CA002474783A patent/CA2474783A1/en not_active Abandoned
- 2003-02-05 NZ NZ534540A patent/NZ534540A/en not_active IP Right Cessation
- 2003-02-05 US US10/497,206 patent/US20050106724A1/en not_active Abandoned
- 2003-02-05 AT AT03704549T patent/ATE397654T1/de not_active IP Right Cessation
- 2003-02-05 EP EP03704549A patent/EP1456357B1/en not_active Expired - Lifetime
- 2003-02-05 DE DE60321440T patent/DE60321440D1/de not_active Expired - Lifetime
-
2008
- 2008-02-11 US US12/068,695 patent/US8192987B2/en not_active Expired - Fee Related
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