JP2005513507A5 - - Google Patents
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- Publication number
- JP2005513507A5 JP2005513507A5 JP2003556815A JP2003556815A JP2005513507A5 JP 2005513507 A5 JP2005513507 A5 JP 2005513507A5 JP 2003556815 A JP2003556815 A JP 2003556815A JP 2003556815 A JP2003556815 A JP 2003556815A JP 2005513507 A5 JP2005513507 A5 JP 2005513507A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- cells
- labeled
- polypeptide
- peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 30
- 108090000765 processed proteins & peptides Proteins 0.000 claims 19
- 102000004169 proteins and genes Human genes 0.000 claims 16
- 108090000623 proteins and genes Proteins 0.000 claims 16
- 235000018102 proteins Nutrition 0.000 claims 15
- 102000004196 processed proteins & peptides Human genes 0.000 claims 10
- 239000003153 chemical reaction reagent Substances 0.000 claims 9
- 229920001184 polypeptide Polymers 0.000 claims 9
- 239000000203 mixture Substances 0.000 claims 8
- 238000001228 spectrum Methods 0.000 claims 7
- 239000012634 fragment Substances 0.000 claims 5
- 238000004949 mass spectrometry Methods 0.000 claims 5
- 238000002372 labelling Methods 0.000 claims 4
- XVGZBALMNMZTIO-UHFFFAOYSA-N 2-[[1-(2,5-dioxopyrrolidin-1-yl)-2H-pyridin-4-yl]methylsulfanyl]acetic acid Chemical group C1=CC(CSCC(=O)O)=CCN1N1C(=O)CCC1=O XVGZBALMNMZTIO-UHFFFAOYSA-N 0.000 claims 3
- 238000004458 analytical method Methods 0.000 claims 3
- 230000007935 neutral effect Effects 0.000 claims 3
- -1 2,3,5,6-tetradeuterio-pyridyl Chemical group 0.000 claims 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims 2
- 150000001412 amines Chemical class 0.000 claims 2
- 238000004132 cross linking Methods 0.000 claims 2
- 230000029087 digestion Effects 0.000 claims 2
- 238000000605 extraction Methods 0.000 claims 2
- 150000002500 ions Chemical class 0.000 claims 2
- 238000004366 reverse phase liquid chromatography Methods 0.000 claims 2
- 108010051815 Glutamyl endopeptidase Proteins 0.000 claims 1
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 claims 1
- 108010052285 Membrane Proteins Proteins 0.000 claims 1
- 102000018697 Membrane Proteins Human genes 0.000 claims 1
- 108010030544 Peptidyl-Lys metalloendopeptidase Proteins 0.000 claims 1
- 150000001413 amino acids Chemical group 0.000 claims 1
- 238000005571 anion exchange chromatography Methods 0.000 claims 1
- ATDGTVJJHBUTRL-UHFFFAOYSA-N cyanogen bromide Chemical compound BrC#N ATDGTVJJHBUTRL-UHFFFAOYSA-N 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 238000005040 ion trap Methods 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 238000000148 multi-dimensional chromatography Methods 0.000 claims 1
- 238000001323 two-dimensional chromatography Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0130845.1A GB0130845D0 (en) | 2001-12-22 | 2001-12-22 | Analysis |
| PCT/EP2002/014328 WO2003056343A2 (en) | 2001-12-22 | 2002-12-16 | Method for protein expression analysis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005513507A JP2005513507A (ja) | 2005-05-12 |
| JP2005513507A5 true JP2005513507A5 (https=) | 2006-02-09 |
Family
ID=9928324
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003556815A Pending JP2005513507A (ja) | 2001-12-22 | 2002-12-16 | タンパク質発現分析方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20050164336A1 (https=) |
| EP (1) | EP1472542A2 (https=) |
| JP (1) | JP2005513507A (https=) |
| AU (1) | AU2002364749A1 (https=) |
| CA (1) | CA2471346A1 (https=) |
| GB (1) | GB0130845D0 (https=) |
| WO (1) | WO2003056343A2 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040219685A1 (en) | 2003-01-30 | 2004-11-04 | Applera Corporation | Methods and mixtures pertaining to analyte determination using electrophilic labeling reagents |
| GB0314209D0 (en) * | 2003-06-19 | 2003-07-23 | Amersham Biosciences Ab | Novel MS reagents |
| WO2005012247A1 (en) * | 2003-07-30 | 2005-02-10 | Hôpital Sainte-Justine | Compounds and methods for the rapid quantitative analysis of proteins and polypeptides |
| WO2005015239A2 (en) * | 2003-08-07 | 2005-02-17 | Cornell Research Foundation, Inc. | Method for n-terminal labeling of proteins |
| DE10340521B4 (de) * | 2003-09-03 | 2012-01-05 | Bruker Daltonik Gmbh | Verfahren selektiver Kapillarelektrophorese |
| EP1916527A1 (en) * | 2003-11-26 | 2008-04-30 | Applera Corporation | Analysis of mass spectral data in the quiet zones |
| CA2542941C (en) * | 2003-11-26 | 2013-02-12 | Applera Corporation | Analysis of mass spectral data in the quiet zones and label selection therefor |
| US20050148087A1 (en) | 2004-01-05 | 2005-07-07 | Applera Corporation | Isobarically labeled analytes and fragment ions derived therefrom |
| KR100611313B1 (ko) * | 2004-06-30 | 2006-08-10 | 고려대학교 산학협력단 | 폴리펩티드의 ｎ-말단 치환용 화합물, 이를 이용한폴리펩티드 내의 아미노산 서열분석 및 정량방법 |
| US8105838B2 (en) * | 2005-06-03 | 2012-01-31 | Waters Technologies Corporation | Generation and use of a catalog of polypeptide-related information for chemical analyses |
| JP4724816B2 (ja) * | 2005-09-06 | 2011-07-13 | シャープ株式会社 | タンパク質の測定方法 |
| JP5003274B2 (ja) * | 2007-05-16 | 2012-08-15 | 株式会社日立製作所 | 質量分析システムおよび質量分析方法 |
| JP5551702B2 (ja) | 2008-09-16 | 2014-07-16 | ヒストロックス，インコーポレイテッド． | バイオマーカー発現の再現性のある定量 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9223168D0 (en) * | 1992-11-05 | 1992-12-16 | Johnson Matthey Plc | Improvements in molecule labelling |
| AUPQ664300A0 (en) * | 2000-04-03 | 2000-05-04 | Proteome Systems Ltd | Macromolecule detection |
| GB0123858D0 (en) * | 2001-10-05 | 2001-11-28 | James Peter | Method for analysing protein/peptide expression |
-
2001
- 2001-12-22 GB GBGB0130845.1A patent/GB0130845D0/en not_active Ceased
-
2002
- 2002-12-16 EP EP02805756A patent/EP1472542A2/en not_active Withdrawn
- 2002-12-16 US US10/499,885 patent/US20050164336A1/en not_active Abandoned
- 2002-12-16 CA CA002471346A patent/CA2471346A1/en not_active Abandoned
- 2002-12-16 JP JP2003556815A patent/JP2005513507A/ja active Pending
- 2002-12-16 AU AU2002364749A patent/AU2002364749A1/en not_active Abandoned
- 2002-12-16 WO PCT/EP2002/014328 patent/WO2003056343A2/en not_active Ceased
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