JP2005512995A - 不安定又は過活動膀胱を治療するための抗ムスカリン剤及びエストロゲンアゴニスト - Google Patents
不安定又は過活動膀胱を治療するための抗ムスカリン剤及びエストロゲンアゴニスト Download PDFInfo
- Publication number
- JP2005512995A JP2005512995A JP2003541815A JP2003541815A JP2005512995A JP 2005512995 A JP2005512995 A JP 2005512995A JP 2003541815 A JP2003541815 A JP 2003541815A JP 2003541815 A JP2003541815 A JP 2003541815A JP 2005512995 A JP2005512995 A JP 2005512995A
- Authority
- JP
- Japan
- Prior art keywords
- tolterodine
- antimuscarinic agent
- overactive bladder
- effective amount
- antimuscarinic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 206010020853 Hypertonic bladder Diseases 0.000 title claims abstract description 38
- 229940011871 estrogen Drugs 0.000 title claims abstract description 27
- 239000000262 estrogen Substances 0.000 title claims abstract description 27
- 208000009722 Overactive Urinary Bladder Diseases 0.000 title claims abstract description 25
- 208000020629 overactive bladder Diseases 0.000 title claims abstract description 24
- 239000000556 agonist Substances 0.000 title claims abstract description 14
- 230000001022 anti-muscarinic effect Effects 0.000 title 1
- OOGJQPCLVADCPB-HXUWFJFHSA-N tolterodine Chemical group C1([C@@H](CCN(C(C)C)C(C)C)C=2C(=CC=C(C)C=2)O)=CC=CC=C1 OOGJQPCLVADCPB-HXUWFJFHSA-N 0.000 claims abstract description 53
- 229960004045 tolterodine Drugs 0.000 claims abstract description 52
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- 239000003149 muscarinic antagonist Substances 0.000 claims abstract description 23
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- DUXZAXCGJSBGDW-FQEVSTJZSA-N 2-[(1s)-3-[di(propan-2-yl)amino]-1-phenylpropyl]-4-(hydroxymethyl)phenol Chemical compound C1([C@H](CCN(C(C)C)C(C)C)C=2C(=CC=C(CO)C=2)O)=CC=CC=C1 DUXZAXCGJSBGDW-FQEVSTJZSA-N 0.000 description 1
- OOGJQPCLVADCPB-FQEVSTJZSA-N 2-[(1s)-3-[di(propan-2-yl)amino]-1-phenylpropyl]-4-methylphenol Chemical compound C1([C@H](CCN(C(C)C)C(C)C)C=2C(=CC=C(C)C=2)O)=CC=CC=C1 OOGJQPCLVADCPB-FQEVSTJZSA-N 0.000 description 1
- 206010005003 Bladder cancer Diseases 0.000 description 1
- 206010071445 Bladder outlet obstruction Diseases 0.000 description 1
- DUXZAXCGJSBGDW-HXUWFJFHSA-N Desfesoterodine Chemical compound C1([C@@H](CCN(C(C)C)C(C)C)C=2C(=CC=C(CO)C=2)O)=CC=CC=C1 DUXZAXCGJSBGDW-HXUWFJFHSA-N 0.000 description 1
- DNXHEGUUPJUMQT-CBZIJGRNSA-N Estrone Chemical compound OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 DNXHEGUUPJUMQT-CBZIJGRNSA-N 0.000 description 1
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- 102000014415 Muscarinic acetylcholine receptor Human genes 0.000 description 1
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- 230000002730 additional effect Effects 0.000 description 1
- 239000000695 adrenergic alpha-agonist Substances 0.000 description 1
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- PROQIPRRNZUXQM-ZXXIGWHRSA-N estriol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H]([C@H](O)C4)O)[C@@H]4[C@@H]3CCC2=C1 PROQIPRRNZUXQM-ZXXIGWHRSA-N 0.000 description 1
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- DLNKOYKMWOXYQA-APPZFPTMSA-N phenylpropanolamine Chemical compound C[C@@H](N)[C@H](O)C1=CC=CC=C1 DLNKOYKMWOXYQA-APPZFPTMSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
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- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Pregnancy & Childbirth (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34450701P | 2001-11-09 | 2001-11-09 | |
| PCT/SE2002/002041 WO2003039524A1 (en) | 2001-11-09 | 2002-11-07 | Anti-muscarinic agent and estrogen-agonist for treating unstable or overactive bladder |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005512995A true JP2005512995A (ja) | 2005-05-12 |
| JP2005512995A5 JP2005512995A5 (OSRAM) | 2005-12-22 |
Family
ID=23350815
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003541815A Withdrawn JP2005512995A (ja) | 2001-11-09 | 2002-11-07 | 不安定又は過活動膀胱を治療するための抗ムスカリン剤及びエストロゲンアゴニスト |
| JP2003541844A Pending JP2005514345A (ja) | 2001-11-09 | 2002-11-12 | 更年期以降の女性生殖機能障害の治療のための組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003541844A Pending JP2005514345A (ja) | 2001-11-09 | 2002-11-12 | 更年期以降の女性生殖機能障害の治療のための組成物 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20030118633A1 (OSRAM) |
| EP (2) | EP1441707A1 (OSRAM) |
| JP (2) | JP2005512995A (OSRAM) |
| CA (2) | CA2466336A1 (OSRAM) |
| MX (2) | MXPA04003866A (OSRAM) |
| WO (2) | WO2003039524A1 (OSRAM) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011518783A (ja) * | 2008-04-09 | 2011-06-30 | コンサート ファーマシューティカルズ インコーポレイテッド | ３−（２−ヒドロキシ−５−メチルフェニル）−ｎ，ｎ−ジイソプロピル−３−フェニルプロピルアミンの誘導体およびその使用方法 |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002366800B2 (en) | 2001-12-20 | 2006-08-03 | Femmepharma Holding Company, Inc. | Vaginal delivery of drugs |
| WO2004043429A1 (en) * | 2002-11-12 | 2004-05-27 | Pharmacia & Upjohn Company | Combination therapy for postmenopausal female sexual dysfunction comprising an androgen, and at least one agent selected from an estrogen and an anti-muscarinic |
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| JP5603598B2 (ja) | 2007-01-08 | 2014-10-08 | ミセル テクノロジーズ、インコーポレイテッド | 生物分解層を有するステント |
| US11426494B2 (en) | 2007-01-08 | 2022-08-30 | MT Acquisition Holdings LLC | Stents having biodegradable layers |
| US20080181932A1 (en) * | 2007-01-30 | 2008-07-31 | Drugtech Corporation | Compositions for oral delivery of pharmaceuticals |
| US9433516B2 (en) | 2007-04-17 | 2016-09-06 | Micell Technologies, Inc. | Stents having controlled elution |
| AU2008256684B2 (en) | 2007-05-25 | 2012-06-14 | Micell Technologies, Inc. | Polymer films for medical device coating |
| US8871275B2 (en) | 2007-08-08 | 2014-10-28 | Inventia Healthcare Private Limited | Extended release compositions comprising tolterodine |
| BRPI0910969B8 (pt) | 2008-04-17 | 2021-06-22 | Micell Technologies Inc | dispositivo |
| GR1006406B (el) * | 2008-05-06 | 2009-05-26 | Specifar Abee ���������� ������� ��� ������������� ��������� | Μικροδισκια παρατεταμενης αποδεσμευσης της τρυγικης τολτεροδινης |
| EP2313122B1 (en) | 2008-07-17 | 2019-03-06 | Micell Technologies, Inc. | Drug delivery medical device |
| WO2011009096A1 (en) | 2009-07-16 | 2011-01-20 | Micell Technologies, Inc. | Drug delivery medical device |
| US8834913B2 (en) | 2008-12-26 | 2014-09-16 | Battelle Memorial Institute | Medical implants and methods of making medical implants |
| EP2411083A4 (en) | 2009-03-23 | 2013-11-13 | Micell Technologies Inc | MEDICAL ACTIVE COMPOSITION DEVICE |
| EP2413847A4 (en) | 2009-04-01 | 2013-11-27 | Micell Technologies Inc | COATED STENTS |
| US20110003000A1 (en) * | 2009-07-06 | 2011-01-06 | Femmepharma Holding Company, Inc. | Transvaginal Delivery of Drugs |
| EP2531140B1 (en) | 2010-02-02 | 2017-11-01 | Micell Technologies, Inc. | Stent and stent delivery system with improved deliverability |
| US8795762B2 (en) | 2010-03-26 | 2014-08-05 | Battelle Memorial Institute | System and method for enhanced electrostatic deposition and surface coatings |
| WO2011133655A1 (en) | 2010-04-22 | 2011-10-27 | Micell Technologies, Inc. | Stents and other devices having extracellular matrix coating |
| EP2593039B1 (en) | 2010-07-16 | 2022-11-30 | Micell Technologies, Inc. | Drug delivery medical device |
| WO2012166819A1 (en) | 2011-05-31 | 2012-12-06 | Micell Technologies, Inc. | System and process for formation of a time-released, drug-eluting transferable coating |
| WO2013012689A1 (en) | 2011-07-15 | 2013-01-24 | Micell Technologies, Inc. | Drug delivery medical device |
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| EP2687215B1 (en) * | 2012-07-18 | 2018-11-28 | Georges Debled | Mesterolone pharmaceutical composition for dihydrotestosterone deficiencies in woman |
| US20140045806A1 (en) * | 2012-07-25 | 2014-02-13 | Fernand Labrie | Sexual arousal, sexual desire, orgasm and/or pleasure following intravaginal prasterone (dhea) administration in women not suffering or independently from dyspareunia or other symptoms of vulvo-vaginal atrophy |
| JP6330024B2 (ja) | 2013-03-12 | 2018-05-23 | マイセル・テクノロジーズ，インコーポレイテッド | 生体吸収性バイオメディカルインプラント |
| JP2016519965A (ja) | 2013-05-15 | 2016-07-11 | マイセル・テクノロジーズ，インコーポレイテッド | 生体吸収性バイオメディカルインプラント |
| AU2014349132A1 (en) * | 2013-10-22 | 2016-04-14 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositons and methods |
| WO2018093369A1 (en) * | 2016-11-17 | 2018-05-24 | Goren Ofer A | Treatment of sexual dysfunction and for improved sexual quality of life |
| CN117956979A (zh) * | 2021-09-10 | 2024-04-30 | 斯塔特拉制药股份有限公司 | 局部递送生长和修复促进化合物以治疗、减少和/或预防压力性尿失禁和大便失禁 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US262115A (en) * | 1882-08-01 | Moeeis pollak | ||
| US5382600A (en) * | 1988-01-22 | 1995-01-17 | Pharmacia Aktiebolag | 3,3-diphenylpropylamines and pharmaceutical compositions thereof |
| SE9203318D0 (sv) * | 1992-11-06 | 1992-11-06 | Kabi Pharmacia Ab | Novel 3,3-diphenylpropylamines, their use and preparation |
| US6262115B1 (en) * | 1995-05-22 | 2001-07-17 | Alza Coporation | Method for the management of incontinence |
| AU728395B2 (en) * | 1996-07-19 | 2001-01-11 | Gunnar Aberg | S(-)-tolterodine in the treatment of urinary and gastrointestinal disorders |
| SE9701144D0 (sv) * | 1997-03-27 | 1997-03-27 | Pharmacia & Upjohn Ab | Novel compounds, their use and preparation |
| WO2000012069A1 (en) * | 1998-08-27 | 2000-03-09 | Pharmacia & Upjohn Ab | Therapeutic formulation for administering tolterodine with controlled release |
| TR200200406T2 (tr) * | 1999-06-11 | 2002-06-21 | Watson Pharmaceuticals, Inc. | Kadınlara oral olmayan yollarla androjenik steroidlerin uygulanması |
| IL157009A0 (en) * | 2001-03-28 | 2004-02-08 | Pfizer | N-phenpropylcyclopentyl-substituted glutaramide derivatives as nep inhibitors for fsad |
-
2002
- 2002-11-07 MX MXPA04003866A patent/MXPA04003866A/es not_active Application Discontinuation
- 2002-11-07 CA CA002466336A patent/CA2466336A1/en not_active Abandoned
- 2002-11-07 JP JP2003541815A patent/JP2005512995A/ja not_active Withdrawn
- 2002-11-07 EP EP02783937A patent/EP1441707A1/en not_active Withdrawn
- 2002-11-07 WO PCT/SE2002/002041 patent/WO2003039524A1/en not_active Ceased
- 2002-11-07 US US10/289,903 patent/US20030118633A1/en not_active Abandoned
- 2002-11-12 EP EP02789581A patent/EP1443939A1/en not_active Withdrawn
- 2002-11-12 MX MXPA04004364A patent/MXPA04004364A/es unknown
- 2002-11-12 WO PCT/US2002/036167 patent/WO2003039553A1/en not_active Ceased
- 2002-11-12 US US10/292,742 patent/US20030130244A1/en not_active Abandoned
- 2002-11-12 CA CA002464707A patent/CA2464707A1/en not_active Abandoned
- 2002-11-12 JP JP2003541844A patent/JP2005514345A/ja active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011518783A (ja) * | 2008-04-09 | 2011-06-30 | コンサート ファーマシューティカルズ インコーポレイテッド | ３−（２−ヒドロキシ−５−メチルフェニル）−ｎ，ｎ−ジイソプロピル−３−フェニルプロピルアミンの誘導体およびその使用方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003039553B1 (en) | 2004-07-08 |
| WO2003039524A1 (en) | 2003-05-15 |
| EP1443939A1 (en) | 2004-08-11 |
| CA2464707A1 (en) | 2003-05-09 |
| CA2466336A1 (en) | 2003-05-15 |
| JP2005514345A (ja) | 2005-05-19 |
| US20030130244A1 (en) | 2003-07-10 |
| US20030118633A1 (en) | 2003-06-26 |
| MXPA04004364A (es) | 2004-08-11 |
| WO2003039553A1 (en) | 2003-05-15 |
| MXPA04003866A (es) | 2004-07-08 |
| EP1441707A1 (en) | 2004-08-04 |
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