GR1006406B - Μικροδισκια παρατεταμενης αποδεσμευσης της τρυγικης τολτεροδινης - Google Patents

Μικροδισκια παρατεταμενης αποδεσμευσης της τρυγικης τολτεροδινης

Info

Publication number
GR1006406B
GR1006406B GR20080100298A GR20080100298A GR1006406B GR 1006406 B GR1006406 B GR 1006406B GR 20080100298 A GR20080100298 A GR 20080100298A GR 20080100298 A GR20080100298 A GR 20080100298A GR 1006406 B GR1006406 B GR 1006406B
Authority
GR
Greece
Prior art keywords
sustained release
microtablets
tolterodine tartrate
coated
api
Prior art date
Application number
GR20080100298A
Other languages
English (en)
Inventor
Original Assignee
Specifar Abee ���������� ������� ��� ������������� ���������
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Specifar Abee ���������� ������� ��� ������������� ��������� filed Critical Specifar Abee ���������� ������� ��� ������������� ���������
Priority to GR20080100298A priority Critical patent/GR1006406B/el
Priority to AT08758931T priority patent/ATE542524T1/de
Priority to PCT/EP2008/004362 priority patent/WO2009135520A1/en
Priority to EP08758931A priority patent/EP2150241B1/en
Publication of GR1006406B publication Critical patent/GR1006406B/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)

Abstract

Η εφεύρεση αφορά σε μικροδισκία παρατεταμένης αποδέσμευσης της Τρυγικής Τολτεροδίνης. Τα εν λόγω μικροδισκία παρέχουν τη δυνατότητα παράτασης της απελευθέρωσης της συγκεκριμένης φαρμακολογικά δραστικής ουσίας για περισσότερο από 8 ώρες γεγονός που τα καθιστά κατάλληλα ως μία μορφή ημερήσιας χορήγησης της τρυγικής Τολτεροδίνης. Επιπλέον, τα συγκεκριμένα μικροδισκία έχουν διάμετρο μεταξύ 2-3mm οπότε μπορούν να μορφοποιηθούν σε πολυμοναδιαίες φαρμακοτεχνικές μορφές ελεγχόμενης αποδέσμευσης, με παρόμοια in vivo συμπεριφορά με εκείνη των επικαλυμμένων σφαιριδίων. Σε αυτήν τη βάση αποτελούν μία ιδιαίτερα ελκυστική εναλλακτική έναντι των επικαλυμμένων σφαιριδίων, καθώς παράγονται μέσω μίας απλής διεργασίας και δεν υπόκεινται σε γήρανση αφού τα ίδια δε φέρουν επικάλυψη.
GR20080100298A 2008-05-06 2008-05-06 Μικροδισκια παρατεταμενης αποδεσμευσης της τρυγικης τολτεροδινης GR1006406B (el)

Priority Applications (4)

Application Number Priority Date Filing Date Title
GR20080100298A GR1006406B (el) 2008-05-06 2008-05-06 Μικροδισκια παρατεταμενης αποδεσμευσης της τρυγικης τολτεροδινης
AT08758931T ATE542524T1 (de) 2008-05-06 2008-06-02 Tolterodintartrathaltige mikrotabletten mit verzögerter freisetzung
PCT/EP2008/004362 WO2009135520A1 (en) 2008-05-06 2008-06-02 Sustained release microtablets comprising tolterodine tartrate
EP08758931A EP2150241B1 (en) 2008-05-06 2008-06-02 Sustained release microtablets comprising tolterodine tartrate

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GR20080100298A GR1006406B (el) 2008-05-06 2008-05-06 Μικροδισκια παρατεταμενης αποδεσμευσης της τρυγικης τολτεροδινης

Publications (1)

Publication Number Publication Date
GR1006406B true GR1006406B (el) 2009-05-26

Family

ID=40121232

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20080100298A GR1006406B (el) 2008-05-06 2008-05-06 Μικροδισκια παρατεταμενης αποδεσμευσης της τρυγικης τολτεροδινης

Country Status (4)

Country Link
EP (1) EP2150241B1 (el)
AT (1) ATE542524T1 (el)
GR (1) GR1006406B (el)
WO (1) WO2009135520A1 (el)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009019599A2 (en) 2007-08-08 2009-02-12 Themis Laboratories Private Limited Extended release compositions comprising tolterodine

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003039553A1 (en) * 2001-11-09 2003-05-15 Pharmacia Corporation Compositions for treatment of postmenopausal female sexual dysfunction
WO2005048979A2 (en) * 2003-10-06 2005-06-02 Torrent Pharmaceuticals Limited Pharmaceutical composition having casing with multiple micro tablets
WO2005105036A1 (en) * 2004-04-28 2005-11-10 Natco Pharma Limited Controlled release mucoadhesive matrix formulation containing tolterodine and a process for its preparation
WO2007011131A1 (en) * 2005-07-22 2007-01-25 Chong Kun Dang Pharmaceutical Corp. Stable controlled-release pellet containing tolterodine
WO2007046590A1 (en) * 2005-10-17 2007-04-26 Gl Pharmtech Corp. New sustained-release multiple unit dosage form
EP1839649A1 (en) * 2006-03-31 2007-10-03 LEK Pharmaceuticals D.D. Coated formulations for tolterodine

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003039553A1 (en) * 2001-11-09 2003-05-15 Pharmacia Corporation Compositions for treatment of postmenopausal female sexual dysfunction
WO2005048979A2 (en) * 2003-10-06 2005-06-02 Torrent Pharmaceuticals Limited Pharmaceutical composition having casing with multiple micro tablets
WO2005105036A1 (en) * 2004-04-28 2005-11-10 Natco Pharma Limited Controlled release mucoadhesive matrix formulation containing tolterodine and a process for its preparation
WO2007011131A1 (en) * 2005-07-22 2007-01-25 Chong Kun Dang Pharmaceutical Corp. Stable controlled-release pellet containing tolterodine
WO2007046590A1 (en) * 2005-10-17 2007-04-26 Gl Pharmtech Corp. New sustained-release multiple unit dosage form
EP1839649A1 (en) * 2006-03-31 2007-10-03 LEK Pharmaceuticals D.D. Coated formulations for tolterodine

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PODCZECK F ET AL: "Gastrointestinal transit of model mini-tablet controlled release oral dosage forms in fasted human volunteers", JOURNAL OF PHARMACY AND PHARMACOLOGY, vol. 59, no. 7, July 2007 (2007-07-01), pages 941 - 945, XP009110272, ISSN: 0022-3573 *

Also Published As

Publication number Publication date
WO2009135520A1 (en) 2009-11-12
EP2150241B1 (en) 2012-01-25
EP2150241A1 (en) 2010-02-10
ATE542524T1 (de) 2012-02-15

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