JP2005512961A - ヒト癌の組合せ療法的処置、及び腫瘍転移並びに微小残存病変処置のためのバルプロ酸及びその誘導体 - Google Patents
ヒト癌の組合せ療法的処置、及び腫瘍転移並びに微小残存病変処置のためのバルプロ酸及びその誘導体 Download PDFInfo
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A—HUMAN NECESSITIES
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- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01121722A EP1293205A1 (en) | 2001-09-18 | 2001-09-18 | Valproic acid and derivatives thereof for the combination therapy of human cancers, for the treatment of tumour metastasis and minimal residual disease |
| EP01121722.1 | 2001-09-18 | ||
| PCT/EP2002/010419 WO2003024442A2 (en) | 2001-09-18 | 2002-09-17 | Valproic acid and derivatives for the combinatorial therapeutic treatment of human cancers and for the treatment of tumor metastasis and minimal residual disease |
Publications (2)
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| JP2005512961A true JP2005512961A (ja) | 2005-05-12 |
| JP2005512961A5 JP2005512961A5 (https=) | 2005-12-22 |
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|---|---|
| US (1) | US20050038113A1 (https=) |
| EP (4) | EP1293205A1 (https=) |
| JP (1) | JP2005512961A (https=) |
| AT (1) | ATE314063T1 (https=) |
| AU (1) | AU2002338716B2 (https=) |
| CA (1) | CA2460713A1 (https=) |
| CY (1) | CY1105552T1 (https=) |
| DE (1) | DE60208397T2 (https=) |
| DK (1) | DK1427403T3 (https=) |
| ES (1) | ES2252519T3 (https=) |
| WO (1) | WO2003024442A2 (https=) |
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| WO2007108272A1 (ja) * | 2006-03-23 | 2007-09-27 | Tmrc Co., Ltd. | 癌治療用キットおよび癌治療用医薬組成物 |
| JP2010511597A (ja) * | 2006-12-06 | 2010-04-15 | 北海道公立大学法人 札幌医科大学 | ヒストン脱アセチル化酵素阻害活性を有する物質を用いた細胞性免疫増強剤 |
| WO2010064422A1 (ja) * | 2008-12-02 | 2010-06-10 | 静岡県公立大学法人 | ヒストン高アセチル化状態における光増感処理による腫瘍殺傷法 |
| JP2010527908A (ja) * | 2006-12-19 | 2010-08-19 | サイクラセル リミテッド | Ｃｎｄａｃ（２’−シアノ−２’−デオキシ−ｎ４−パルミトイル−１−ベータ−ｄ−アラビノフラノシル−シトシン）及び細胞毒性薬を含む組合せ |
| WO2012047007A3 (ko) * | 2010-10-06 | 2012-07-05 | (주)아모레퍼시픽 | 손톱 또는 발톱 성장 촉진용 조성물 |
| JP2014510102A (ja) * | 2011-03-21 | 2014-04-24 | ヴァルキュリア アクチアボラグ | Ｈｄａｃ阻害剤及びステロイドを含む医薬組成物及びその使用 |
| JP2015216853A (ja) * | 2014-05-14 | 2015-12-07 | 国立大学法人京都大学 | 巨核球前駆細胞の製造方法 |
| WO2023008459A1 (ja) * | 2021-07-27 | 2023-02-02 | 東レ株式会社 | 癌の治療及び／又は予防のための医薬品 |
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| US7154002B1 (en) | 2002-10-08 | 2006-12-26 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| US7250514B1 (en) | 2002-10-21 | 2007-07-31 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| US7381825B2 (en) * | 2003-03-17 | 2008-06-03 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| MXPA05012464A (es) * | 2003-05-21 | 2006-01-30 | Novartis Ag | Combinacion de inhibidores de deacetilasa de histona con agentes quimioterapeuticos. |
| EP1491188A1 (en) * | 2003-06-25 | 2004-12-29 | G2M Cancer Drugs AG | Topical use of valproic acid for the prevention or treatment of skin disorders |
| CN102349927A (zh) * | 2003-08-29 | 2012-02-15 | Hdac默克研究有限责任公司 | 联合治疗癌症的方法 |
| US20050159470A1 (en) * | 2003-12-19 | 2005-07-21 | Syrrx, Inc. | Histone deacetylase inhibitors |
| US20050137234A1 (en) * | 2003-12-19 | 2005-06-23 | Syrrx, Inc. | Histone deacetylase inhibitors |
| US7951780B2 (en) | 2004-02-25 | 2011-05-31 | Astellas Pharma Inc. | Antitumor agent |
| EP1824831A2 (en) * | 2004-12-16 | 2007-08-29 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| JP5156392B2 (ja) * | 2005-02-03 | 2013-03-06 | トポターゲット ユーケー リミテッド | Ｈｄａｃ阻害剤を用いる併用療法 |
| US7869590B2 (en) * | 2005-04-12 | 2011-01-11 | Broadcom Corporation | Method and system for hardware accelerator for implementing f9 integrity algorithm in WCDMA compliant handsets |
| EP1896436A2 (en) * | 2005-05-11 | 2008-03-12 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| ATE542527T1 (de) | 2005-05-13 | 2012-02-15 | Topotarget Uk Ltd | Pharmazeutische formulierungen von hdac-hemmern |
| EA200800321A1 (ru) * | 2005-07-14 | 2008-06-30 | Такеда Сан Диего, Инк. | Ингибиторы гистондеацетилазы |
| WO2007054719A2 (en) | 2005-11-10 | 2007-05-18 | Topotarget Uk Limited | Histone deacetylase (hdac) inhibitors (pxdlol) for the treatment of cancer alone or in combination with chemotherapeutic agent |
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| RU2389484C2 (ru) * | 2005-11-18 | 2010-05-20 | Универсидад Насиональ Аутонома Де Мексико | Применение модифицирующих транскриптом агентов и химиотерапии или радиотерапии против рака |
| JP2009525955A (ja) * | 2006-01-13 | 2009-07-16 | タケダ サン ディエゴ インコーポレイテッド | ヒストンデアセチラーゼ阻害剤 |
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| US8642809B2 (en) | 2007-09-25 | 2014-02-04 | Topotarget Uk Ltd. | Methods of synthesis of certain hydroxamic acid compounds |
| US8491927B2 (en) | 2009-12-02 | 2013-07-23 | Nimble Epitech, Llc | Pharmaceutical composition containing a hypomethylating agent and a histone deacetylase inhibitor |
| NZ605526A (en) | 2010-07-12 | 2015-04-24 | Celgene Corp | Romidepsin solid forms and uses thereof |
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| AU2013202506B2 (en) | 2012-09-07 | 2015-06-18 | Celgene Corporation | Resistance biomarkers for hdac inhibitors |
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| NZ630311A (en) | 2013-12-27 | 2016-03-31 | Celgene Corp | Romidepsin formulations and uses thereof |
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| US4935450A (en) * | 1982-09-17 | 1990-06-19 | Therapeutical Systems Corporation | Cancer therapy system for effecting oncolysis of malignant neoplasms |
| CA1339034C (en) * | 1988-08-22 | 1997-04-01 | Paul A. Tremblay | Platinum complexes of single isomer neoalkyl acids |
| JPH0279969A (ja) * | 1988-09-19 | 1990-03-20 | Shigeyoshi Fujimoto | 細胞障害性ｔ細胞誘導及び活性化の方法 |
| FR2697752B1 (fr) * | 1992-11-10 | 1995-04-14 | Rhone Poulenc Rorer Sa | Compositions antitumorales contenant des dérivés du taxane. |
| EP0632008B1 (en) * | 1993-06-01 | 1998-02-04 | Ono Pharmaceutical Co., Ltd. | Pentanoic acid derivatives |
| US5672746A (en) * | 1994-08-30 | 1997-09-30 | American Biogenetic Sciences, Inc. | Antiproliferative and neurotrophic molecules |
| US6300373B1 (en) * | 1993-09-10 | 2001-10-09 | American Biogenetic Sciences, Inc. | Antiproliferative and neurotrophic molecules |
| US5786344A (en) * | 1994-07-05 | 1998-07-28 | Arch Development Corporation | Camptothecin drug combinations and methods with reduced side effects |
| ATE229810T1 (de) * | 1996-10-11 | 2003-01-15 | Univ California | Krebs immuntherapie unter verwendung von tumorzellen kombiniert mit lymphozytmischungen |
| US6110955A (en) * | 1997-03-11 | 2000-08-29 | Beacon Laboratories, Inc. | Metabolically stabilized oxyalkylene esters and uses thereof |
| US6110970A (en) * | 1997-03-11 | 2000-08-29 | Beacon Laboratories, Inc. | Nitrogen-containing oxyalkylene esters and uses thereof |
| US6124495A (en) * | 1997-03-11 | 2000-09-26 | Beacon Laboratories, Inc. | Unsaturated oxyalkylene esters and uses thereof |
| US6043389A (en) * | 1997-03-11 | 2000-03-28 | Mor Research Applications, Ltd. | Hydroxy and ether-containing oxyalkylene esters and uses thereof |
| US5939455A (en) * | 1997-03-11 | 1999-08-17 | Beacon Laboratories, Inc. | Therapeutic augmentation of oxyalkylene diesters and butyric acid derivatives |
| US6028102A (en) * | 1998-02-24 | 2000-02-22 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Anticonvulsant drugs and pharmaceutical compositions thereof |
| AU2337601A (en) * | 1999-12-23 | 2001-07-09 | Ontario Cancer Institute, The | Inhibition of gsk-3beta |
| EP1170008A1 (en) * | 2000-07-07 | 2002-01-09 | Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus | Valproic acid and derivatives thereof as histone deacetylase inhibitors |
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2001
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- 2002-09-17 CA CA002460713A patent/CA2460713A1/en not_active Abandoned
- 2002-09-17 US US10/489,770 patent/US20050038113A1/en not_active Abandoned
- 2002-09-17 WO PCT/EP2002/010419 patent/WO2003024442A2/en not_active Ceased
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- 2002-09-17 DK DK02777129T patent/DK1427403T3/da active
- 2002-09-17 EP EP05101081A patent/EP1529527A3/en not_active Withdrawn
- 2002-09-17 JP JP2003528538A patent/JP2005512961A/ja active Pending
- 2002-09-17 EP EP05019659A patent/EP1602371A3/en not_active Withdrawn
-
2006
- 2006-02-28 CY CY20061100277T patent/CY1105552T1/el unknown
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007108272A1 (ja) * | 2006-03-23 | 2007-09-27 | Tmrc Co., Ltd. | 癌治療用キットおよび癌治療用医薬組成物 |
| JP2010511597A (ja) * | 2006-12-06 | 2010-04-15 | 北海道公立大学法人 札幌医科大学 | ヒストン脱アセチル化酵素阻害活性を有する物質を用いた細胞性免疫増強剤 |
| JP2010527908A (ja) * | 2006-12-19 | 2010-08-19 | サイクラセル リミテッド | Ｃｎｄａｃ（２’−シアノ−２’−デオキシ−ｎ４−パルミトイル−１−ベータ−ｄ−アラビノフラノシル−シトシン）及び細胞毒性薬を含む組合せ |
| WO2010064422A1 (ja) * | 2008-12-02 | 2010-06-10 | 静岡県公立大学法人 | ヒストン高アセチル化状態における光増感処理による腫瘍殺傷法 |
| WO2012047007A3 (ko) * | 2010-10-06 | 2012-07-05 | (주)아모레퍼시픽 | 손톱 또는 발톱 성장 촉진용 조성물 |
| KR101733189B1 (ko) | 2010-10-06 | 2017-05-08 | (주)아모레퍼시픽 | 손톱 또는 발톱 성장 촉진용 조성물 |
| JP2014510102A (ja) * | 2011-03-21 | 2014-04-24 | ヴァルキュリア アクチアボラグ | Ｈｄａｃ阻害剤及びステロイドを含む医薬組成物及びその使用 |
| JP2015216853A (ja) * | 2014-05-14 | 2015-12-07 | 国立大学法人京都大学 | 巨核球前駆細胞の製造方法 |
| WO2023008459A1 (ja) * | 2021-07-27 | 2023-02-02 | 東レ株式会社 | 癌の治療及び／又は予防のための医薬品 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003024442A2 (en) | 2003-03-27 |
| EP1602371A2 (en) | 2005-12-07 |
| DK1427403T3 (da) | 2006-04-03 |
| WO2003024442A3 (en) | 2003-09-18 |
| EP1602371A3 (en) | 2006-11-15 |
| EP1427403B1 (en) | 2005-12-28 |
| CY1105552T1 (el) | 2010-07-28 |
| AU2002338716B2 (en) | 2007-08-16 |
| DE60208397D1 (de) | 2006-02-02 |
| ATE314063T1 (de) | 2006-01-15 |
| DE60208397T2 (de) | 2006-07-13 |
| EP1427403A2 (en) | 2004-06-16 |
| EP1293205A1 (en) | 2003-03-19 |
| ES2252519T3 (es) | 2006-05-16 |
| CA2460713A1 (en) | 2003-03-27 |
| EP1529527A3 (en) | 2005-05-25 |
| EP1427403B8 (en) | 2006-03-22 |
| EP1529527A2 (en) | 2005-05-11 |
| US20050038113A1 (en) | 2005-02-17 |
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