JP2005511248A - 物質を送達するための方法およびデバイス - Google Patents

物質を送達するための方法およびデバイス Download PDF

Info

Publication number
JP2005511248A
JP2005511248A JP2003552217A JP2003552217A JP2005511248A JP 2005511248 A JP2005511248 A JP 2005511248A JP 2003552217 A JP2003552217 A JP 2003552217A JP 2003552217 A JP2003552217 A JP 2003552217A JP 2005511248 A JP2005511248 A JP 2005511248A
Authority
JP
Japan
Prior art keywords
micro
skin
abrader
substance
microprojections
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2003552217A
Other languages
English (en)
Japanese (ja)
Inventor
エイ．ミクズタ ジョン
ジェイ．ペティス ロナルド
アラーコン ジェイソン
エム．ブリッティンガム ジョン
ピー．デッカー ザ サード ジョン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Becton Dickinson and Co
Original Assignee
Becton Dickinson and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Becton Dickinson and Co filed Critical Becton Dickinson and Co
Publication of JP2005511248A publication Critical patent/JP2005511248A/ja
Withdrawn legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/54—Chiropodists' instruments, e.g. pedicure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/32—Surgical cutting instruments
    • A61B2017/320004—Surgical cutting instruments abrasive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0061—Methods for using microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Coating Apparatus (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
JP2003552217A 2001-10-29 2002-10-29 物質を送達するための方法およびデバイス Withdrawn JP2005511248A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33071301P 2001-10-29 2001-10-29
US33316201P 2001-11-27 2001-11-27
PCT/US2002/034504 WO2003051284A2 (en) 2001-10-29 2002-10-29 Method and device for the delivery of a substance

Publications (1)

Publication Number Publication Date
JP2005511248A true JP2005511248A (ja) 2005-04-28

Family

ID=26987410

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003552217A Withdrawn JP2005511248A (ja) 2001-10-29 2002-10-29 物質を送達するための方法およびデバイス

Country Status (12)

Country Link
US (1) US20030093040A1 (cg-RX-API-DMAC7.html)
EP (1) EP1439870B1 (cg-RX-API-DMAC7.html)
JP (1) JP2005511248A (cg-RX-API-DMAC7.html)
CN (1) CN1662266A (cg-RX-API-DMAC7.html)
AT (1) ATE420676T1 (cg-RX-API-DMAC7.html)
AU (1) AU2002365144A1 (cg-RX-API-DMAC7.html)
BR (1) BR0213686A (cg-RX-API-DMAC7.html)
CA (1) CA2464994A1 (cg-RX-API-DMAC7.html)
DE (1) DE60230894D1 (cg-RX-API-DMAC7.html)
ES (1) ES2319625T3 (cg-RX-API-DMAC7.html)
MX (1) MXPA04003953A (cg-RX-API-DMAC7.html)
WO (1) WO2003051284A2 (cg-RX-API-DMAC7.html)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010013350A1 (ja) 2008-08-01 2010-02-04 Ａｓｐｉｏｎ株式会社 Ｓ／ｏ型経皮免疫剤
WO2013073121A1 (ja) * 2011-11-18 2013-05-23 南部化成株式会社 経皮投薬装置
JP5241517B2 (ja) * 2007-02-06 2013-07-17 久光製薬株式会社 アレルギー診断用マイクロニードルデバイス

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6641591B1 (en) 1999-08-26 2003-11-04 John H. Shadduck Instruments and techniques for controlled removal of epidermal layers
WO2003002069A2 (en) * 2001-06-29 2003-01-09 Becton, Dickinson And Company Intradermal delivery of vaccines and gene therapeutic agents via microcannula
US20060018877A1 (en) * 2001-06-29 2006-01-26 Mikszta John A Intradermal delivery of vacccines and therapeutic agents
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
JP4469610B2 (ja) * 2002-02-04 2010-05-26 ベクトン・ディキンソン・アンド・カンパニー 皮膚アクセス部材
CA2492867C (en) 2002-07-19 2011-07-05 3M Innovative Properties Company Microneedle devices and microneedle delivery apparatus
US7166086B2 (en) * 2002-08-29 2007-01-23 Becton, Dickinson And Company Substance delivery via a rotating microabrading surface
KR20060038407A (ko) * 2003-06-30 2006-05-03 알자 코포레이션 비휘발성 반대이온을 포함하는 코팅된 미세돌출부용 제제
CA2536249A1 (en) * 2003-08-25 2005-03-10 3M Innovative Properties Company Delivery of immune response modifier compounds
WO2005051456A2 (en) * 2003-11-13 2005-06-09 Alza Corporation Composition and apparatus for transdermal delivery
US20070191761A1 (en) * 2004-02-23 2007-08-16 3M Innovative Properties Company Method of molding for microneedle arrays
SE0402100D0 (sv) * 2004-08-30 2004-08-30 Bonsens Ab Molded micro-needles
MX2007002925A (es) * 2004-09-10 2007-08-14 Becton Dickinson Co Dispositivo de infusion reconstituyente.
US20070053965A1 (en) * 2005-02-25 2007-03-08 Gruenenthal Gmbh Kit comprising a plaster, optionally containing an active substance, and an agent that at least partially reduces skin irritation
CN101912288A (zh) * 2005-09-02 2010-12-15 因特赛尔美国公司 经皮递送疫苗和透皮递送药物的装置及其应用
DE102005044737A1 (de) * 2005-09-19 2007-03-29 Braun Gmbh Verfahren zum Entfernen von Haaren, Haarentfernungsgerät und Aufsatz hierfür
WO2007061964A1 (en) 2005-11-18 2007-05-31 3M Innovative Properties Company Methods for coating microneedles
WO2007064486A1 (en) * 2005-11-30 2007-06-07 3M Innovative Properties Company Microneedle arrays and methods of use thereof
US8048089B2 (en) 2005-12-30 2011-11-01 Edge Systems Corporation Apparatus and methods for treating the skin
JP2010515469A (ja) * 2006-01-12 2010-05-13 ナノパス テクノロジーズ エルティディ． 皮膚表面の研磨処理装置
US10172644B2 (en) 2006-03-29 2019-01-08 Edge Systems Llc Devices, systems and methods for treating the skin
US9566088B2 (en) 2006-03-29 2017-02-14 Edge Systems Llc Devices, systems and methods for treating the skin
AU2007259329A1 (en) * 2006-05-12 2007-12-21 Farris, Darise Anthrax compositions and methods of use and production
EP3388006B1 (en) 2008-01-04 2020-03-04 Edge Systems LLC System for treating skin
US9056193B2 (en) 2008-01-29 2015-06-16 Edge Systems Llc Apparatus and method for treating the skin
US20110009782A1 (en) * 2009-07-07 2011-01-13 Naya Touch, Inc. Dermal roller with therapeutic microstructures
EP2451367B1 (en) 2009-07-08 2020-01-22 Edge Systems Corporation Devices for treating the skin using time-release substances
GB201007207D0 (en) * 2010-04-29 2010-06-16 Univ Cork Method
US9044582B2 (en) * 2012-06-26 2015-06-02 Franklin J. Chang Apparatus and method for transdermal fluid delivery
US10238812B2 (en) 2013-03-15 2019-03-26 Edge Systems Llc Skin treatment systems and methods using needles
EP4179986A1 (en) 2013-03-15 2023-05-17 HydraFacial LLC Devices and systems for treating the skin
US10194935B2 (en) * 2013-12-31 2019-02-05 L'oreal Shear-induced dermal infusion
WO2015148688A1 (en) * 2014-03-26 2015-10-01 Nanomed Skincare, Inc. Plunger-like mass transportation device for dermal and transdermal delivery of a liquid or solid composition
US20170360464A1 (en) * 2014-12-18 2017-12-21 Koninklijke Philips N.V. Microdermabrasion device
US10179229B2 (en) 2014-12-23 2019-01-15 Edge Systems Llc Devices and methods for treating the skin using a porous member
EP3237055B1 (en) 2014-12-23 2020-08-12 Edge Systems LLC Devices and methods for treating the skin using a rollerball or a wicking member
WO2017007939A1 (en) 2015-07-08 2017-01-12 Edge Systems Llc Devices, systems and methods for promoting hair growth
CN108056845A (zh) * 2017-12-15 2018-05-22 深圳清华大学研究院 一种侧路腰椎椎间融合器
US20200093874A1 (en) * 2018-09-24 2020-03-26 Krystal Biotech, Inc. Compositions and methods for the treatment of netherton syndrome
US11291474B2 (en) 2020-01-06 2022-04-05 Ed F. Nicolas Skin treatment tool applicator tip
EP4294446A4 (en) * 2021-02-18 2024-12-04 Agonex Biopharmaceuticals, Inc. SYSTEMS, DEVICES AND FORMULATIONS FOR THE ADMINISTRATION OF FRACTIONATED HISTAMINE
USD1065551S1 (en) 2021-09-10 2025-03-04 Hydrafacial Llc Skin treatment device
USD1016615S1 (en) 2021-09-10 2024-03-05 Hydrafacial Llc Container for a skin treatment device
USD1042807S1 (en) 2021-10-11 2024-09-17 Hydrafacial Llc Skin treatment tip
GB2622416B (en) * 2022-09-15 2025-04-02 Ndm Tech Ltd Skin preparation device
USD1084369S1 (en) 2023-02-10 2025-07-15 Hydrafacial Llc Skin treatment tip
DE102024101897A1 (de) * 2024-01-23 2025-07-24 Gwenaël Bauer Dermabrasionswerkzeug mit auspressbarem Fluidbehälter

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3289670A (en) * 1964-03-09 1966-12-06 Milo Bundy Corp Device for abrading and applying biologicals to the skin of a patient
US3556080A (en) * 1968-04-08 1971-01-19 Lincoln Lab Inc Skin allergy testing device
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
OA05448A (fr) * 1975-10-16 1981-03-31 Manufrance Manufacture Francai Dispositif vaccinateur multipénétrant.
US4270548A (en) * 1979-09-05 1981-06-02 Aller-Screen, Inc. Allergy testing method
FR2474856A1 (fr) * 1980-01-31 1981-08-07 Merieux Inst Dispositif scarificateur
FR2498443B2 (fr) * 1981-01-26 1986-03-28 Merieux Inst Dispositif scarificateur
US4483348A (en) * 1982-03-25 1984-11-20 Nathan Sher Skin testing device
US4597764A (en) * 1983-09-28 1986-07-01 Bruce Black Ossicular replacement prosthesis
US4568343A (en) * 1984-10-09 1986-02-04 Alza Corporation Skin permeation enhancer compositions
US4746515A (en) * 1987-02-26 1988-05-24 Alza Corporation Skin permeation enhancer compositions using glycerol monolaurate
AU614092B2 (en) * 1987-09-11 1991-08-22 Paul Max Grinwald Improved method and apparatus for enhanced drug permeation of skin
TW279133B (cg-RX-API-DMAC7.html) * 1990-12-13 1996-06-21 Elan Med Tech
US5273528A (en) * 1992-07-10 1993-12-28 Skeen Mikell L Livestock inoculator
DE4307869C2 (de) * 1993-03-12 1996-04-04 Microparts Gmbh Mikrostrukturkörper und Verfahren zu deren Herstellung
US5679647A (en) * 1993-08-26 1997-10-21 The Regents Of The University Of California Methods and devices for immunizing a host against tumor-associated antigens through administration of naked polynucleotides which encode tumor-associated antigenic peptides
US5885211A (en) * 1993-11-15 1999-03-23 Spectrix, Inc. Microporation of human skin for monitoring the concentration of an analyte
US5380337A (en) * 1994-01-24 1995-01-10 Romaine; Richard A. Mesh-type skin biopsy appliance
US5660680A (en) * 1994-03-07 1997-08-26 The Regents Of The University Of California Method for fabrication of high vertical aspect ratio thin film structures
CA2149943C (en) * 1994-05-23 1999-07-13 Kwang Kyun Jang Skin perforating device for transdermal medication
US5591139A (en) * 1994-06-06 1997-01-07 The Regents Of The University Of California IC-processed microneedles
US6368333B2 (en) * 1994-06-29 2002-04-09 Mattioli Engineering Ltd. V-shaped handpiece for dermabrasion
WO1996037256A1 (en) * 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical patch for enhancing the delivery of compounds through the skin
WO1996037155A1 (en) * 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical device and method for enhancing delivery of compounds through the skin
US5958589A (en) * 1995-07-07 1999-09-28 The United States Of America As Represented By The Secretary Of Agriculture Starch-based microcellular foams
DE19525607A1 (de) * 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneales Arzneimittelfreigabesystem
US5658515A (en) * 1995-09-25 1997-08-19 Lee; Abraham P. Polymer micromold and fabrication process
US6032060A (en) * 1996-01-25 2000-02-29 3M Innovative Properties Company Method for conditioning skin and an electrode by passing electrical energy
AUPN814496A0 (en) * 1996-02-19 1996-03-14 Monash University Dermal penetration enhancer
US5919364A (en) * 1996-06-24 1999-07-06 Regents Of The University Of California Microfabricated filter and shell constructed with a permeable membrane
ATE241405T1 (de) * 1996-07-03 2003-06-15 Altea Therapeutics Corp Mehrfache mechanische mikroperforierung von haut oder schleimhäuten
WO1998011937A1 (en) * 1996-09-17 1998-03-26 Deka Products Limited Partnership System for delivery of drugs by transport
US5980898A (en) * 1996-11-14 1999-11-09 The United States Of America As Represented By The U.S. Army Medical Research & Material Command Adjuvant for transcutaneous immunization
US5910306A (en) * 1996-11-14 1999-06-08 The United States Of America As Represented By The Secretary Of The Army Transdermal delivery system for antigen
EP1009520A4 (en) * 1997-01-24 2003-05-14 Univ California PLANAR LAMINARY MIXING DEVICE AND METHOD
US5928207A (en) * 1997-06-30 1999-07-27 The Regents Of The University Of California Microneedle with isotropically etched tip, and method of fabricating such a device
US6077229A (en) * 1997-10-21 2000-06-20 Pitesky; Isadore Allergy testing apparatus
US5931794A (en) * 1997-10-21 1999-08-03 Pitesky; Isadore Allergy testing apparatus
US5999847A (en) * 1997-10-21 1999-12-07 Elstrom; John A. Apparatus and method for delivery of surgical and therapeutic agents
CA2313458C (en) * 1997-12-11 2007-04-17 Alza Corporation Device for enhancing transdermal agent flux
US5970998A (en) * 1998-02-27 1999-10-26 The Regents Of The University Of California Microfabricated cantilever ratchet valve, and method for using same
US6173202B1 (en) * 1998-03-06 2001-01-09 Spectrx, Inc. Method and apparatus for enhancing flux rates of a fluid in a microporated biological tissue
US6106751A (en) * 1998-03-18 2000-08-22 The Regents Of The University Of California Method for fabricating needles via conformal deposition in two-piece molds
US7004933B2 (en) * 1998-05-29 2006-02-28 Light Bioscience L.L.C. Ultrasound enhancement of percutaneous drug absorption
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
US6162232A (en) * 1999-03-18 2000-12-19 Shadduck; John H. Instruments and techniques for high-velocity fluid abrasion of epidermal layers with skin cooling
US6582442B2 (en) * 2000-02-28 2003-06-24 Dynatronics Corporation Method and system for performing microabrasion
US6256533B1 (en) * 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6312612B1 (en) * 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array
US6835184B1 (en) * 1999-09-24 2004-12-28 Becton, Dickinson And Company Method and device for abrading skin
US6331266B1 (en) * 1999-09-29 2001-12-18 Becton Dickinson And Company Process of making a molded device
HK1048773B (en) * 1999-12-10 2005-10-14 Alza Corporation Skin treatment apparatus for sustained transdermal drug delivery
EP1239775B1 (en) * 1999-12-16 2005-03-16 ALZA Corporation Device for enhancing transdermal flux of sampled agents
US6706032B2 (en) * 2000-06-08 2004-03-16 Massachusetts Institute Of Technology Localized molecular and ionic transport to and from tissues
KR20030068137A (ko) * 2000-10-13 2003-08-19 알자 코포레이션 충격 어플리케이터용 미세 돌기 부재 리테이너
US6821281B2 (en) * 2000-10-16 2004-11-23 The Procter & Gamble Company Microstructures for treating and conditioning skin
US20020193729A1 (en) * 2001-04-20 2002-12-19 Cormier Michel J.N. Microprojection array immunization patch and method
US20030135166A1 (en) * 2001-09-28 2003-07-17 Gonnelli Robert R. Switchable microneedle arrays and systems and methods relating to same

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5241517B2 (ja) * 2007-02-06 2013-07-17 久光製薬株式会社 アレルギー診断用マイクロニードルデバイス
WO2010013350A1 (ja) 2008-08-01 2010-02-04 Ａｓｐｉｏｎ株式会社 Ｓ／ｏ型経皮免疫剤
WO2013073121A1 (ja) * 2011-11-18 2013-05-23 南部化成株式会社 経皮投薬装置

Also Published As

Publication number Publication date
US20030093040A1 (en) 2003-05-15
AU2002365144A1 (en) 2003-06-30
ATE420676T1 (de) 2009-01-15
EP1439870B1 (en) 2009-01-14
WO2003051284A2 (en) 2003-06-26
EP1439870A2 (en) 2004-07-28
CN1662266A (zh) 2005-08-31
DE60230894D1 (cg-RX-API-DMAC7.html) 2009-03-05
EP1439870A4 (en) 2006-03-01
CA2464994A1 (en) 2003-06-26
BR0213686A (pt) 2006-05-23
ES2319625T3 (es) 2009-05-11
WO2003051284A3 (en) 2004-01-29
MXPA04003953A (es) 2004-06-18

Similar Documents

Publication Publication Date Title
EP1439870B1 (en) Device for the delivery of a substance
JP4917540B2 (ja) 被膜を含む物質の供給方法および装置
Kim et al. Delivery systems for intradermal vaccination
AU2001261757B2 (en) Applicator having abrading surface coated with substance to be applied to skin
JP5611888B2 (ja) 有益な作用物質を含有するコーティングを有する微小突起アレイ
JP2004531578A (ja) ワクチンおよび遺伝子治療剤のマイクロカニューレによる皮内送達
AU2001261757A1 (en) Applicator having abrading surface coated with substance to be applied to skin
JP2004538048A (ja) 微小突起アレイ免疫感作貼付剤および方法
KR20070011481A (ko) 다중 백신의 경피 전달용 기구 및 방법
Naik et al. Drug delivery through microneedles for improved permeability and efficacy: fabrication, methodology and applications
Chandran et al. Recent advances and challenges in microneedle-mediated transdermal protein and peptide drug delivery
EP3251722B1 (en) Microprojection array having a beneficial agent containing coating and method of forming the coating thereon
Arora et al. Microneedle mediated vaccine delivery: a comprehensive review
AU2002327186A1 (en) Intradermal delivery of vaccines and gene therapeutic agents via microcannula
NZ538043A (en) Composition having a beneficial agent for forming a solid coating on microprojections array

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20051017

A761 Written withdrawal of application

Free format text: JAPANESE INTERMEDIATE CODE: A761

Effective date: 20080118