JP2005508916A5 - - Google Patents
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- Publication number
- JP2005508916A5 JP2005508916A5 JP2003531968A JP2003531968A JP2005508916A5 JP 2005508916 A5 JP2005508916 A5 JP 2005508916A5 JP 2003531968 A JP2003531968 A JP 2003531968A JP 2003531968 A JP2003531968 A JP 2003531968A JP 2005508916 A5 JP2005508916 A5 JP 2005508916A5
- Authority
- JP
- Japan
- Prior art keywords
- domain
- composition according
- replication
- dna plasmid
- defective adenovirus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 113
- 241000701161 unidentified adenovirus Species 0.000 claims 73
- 239000013612 plasmid Substances 0.000 claims 72
- 230000003834 intracellular effect Effects 0.000 claims 60
- 108090000288 Glycoproteins Proteins 0.000 claims 49
- 102000003886 Glycoproteins Human genes 0.000 claims 49
- 108020004707 nucleic acids Proteins 0.000 claims 49
- 102000039446 nucleic acids Human genes 0.000 claims 49
- 150000007523 nucleic acids Chemical class 0.000 claims 49
- 230000004927 fusion Effects 0.000 claims 40
- 108090000765 processed proteins & peptides Proteins 0.000 claims 40
- 201000011001 Ebola Hemorrhagic Fever Diseases 0.000 claims 39
- 230000002068 genetic effect Effects 0.000 claims 32
- 102000004961 Furin Human genes 0.000 claims 30
- 108090001126 Furin Proteins 0.000 claims 30
- 238000003776 cleavage reaction Methods 0.000 claims 30
- 230000007017 scission Effects 0.000 claims 30
- 230000002950 deficient Effects 0.000 claims 27
- 230000010076 replication Effects 0.000 claims 27
- 108010061100 Nucleoproteins Proteins 0.000 claims 20
- 102000011931 Nucleoproteins Human genes 0.000 claims 20
- 230000037452 priming Effects 0.000 claims 14
- 108090000623 proteins and genes Proteins 0.000 claims 14
- 241001115401 Marburgvirus Species 0.000 claims 13
- 241001115402 Ebolavirus Species 0.000 claims 10
- 210000004899 c-terminal region Anatomy 0.000 claims 10
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 10
- 230000037430 deletion Effects 0.000 claims 10
- 238000012217 deletion Methods 0.000 claims 10
- 108020004705 Codon Proteins 0.000 claims 9
- 206010023927 Lassa fever Diseases 0.000 claims 9
- 241000700605 Viruses Species 0.000 claims 9
- 239000000427 antigen Substances 0.000 claims 9
- 102000036639 antigens Human genes 0.000 claims 9
- 108091007433 antigens Proteins 0.000 claims 9
- 230000028993 immune response Effects 0.000 claims 6
- 102000007999 Nuclear Proteins Human genes 0.000 claims 5
- 108010089610 Nuclear Proteins Proteins 0.000 claims 5
- 230000009977 dual effect Effects 0.000 claims 5
- 101900102527 Lake Victoria marburgvirus Nucleoprotein Proteins 0.000 claims 4
- 241000271566 Aves Species 0.000 claims 2
- 101710141454 Nucleoprotein Proteins 0.000 claims 2
- 241000700618 Vaccinia virus Species 0.000 claims 2
- 230000003053 immunization Effects 0.000 claims 2
- 238000002649 immunization Methods 0.000 claims 2
- 238000002347 injection Methods 0.000 claims 2
- 239000007924 injection Substances 0.000 claims 2
- 241001529453 unidentified herpesvirus Species 0.000 claims 2
- 241000712461 unidentified influenza virus Species 0.000 claims 2
- 241001430294 unidentified retrovirus Species 0.000 claims 2
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
Images
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32647601P | 2001-10-01 | 2001-10-01 | |
| PCT/US2002/030251 WO2003028632A2 (en) | 2001-10-01 | 2002-09-24 | Development of a preventive vaccine for filovirus infection in primates |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005280131A Division JP4198148B2 (ja) | 2001-10-01 | 2005-09-27 | 霊長類におけるフィロウイルス感染に対する予防ワクチンの開発 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005508916A JP2005508916A (ja) | 2005-04-07 |
| JP2005508916A5 true JP2005508916A5 (https=) | 2006-10-12 |
Family
ID=23272371
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003531968A Pending JP2005508916A (ja) | 2001-10-01 | 2002-09-24 | 霊長類におけるフィロウイルス感染に対する予防ワクチンの開発 |
| JP2005280131A Expired - Lifetime JP4198148B2 (ja) | 2001-10-01 | 2005-09-27 | 霊長類におけるフィロウイルス感染に対する予防ワクチンの開発 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005280131A Expired - Lifetime JP4198148B2 (ja) | 2001-10-01 | 2005-09-27 | 霊長類におけるフィロウイルス感染に対する予防ワクチンの開発 |
Country Status (9)
| Country | Link |
|---|---|
| US (5) | US7635688B2 (https=) |
| EP (1) | EP1504112A4 (https=) |
| JP (2) | JP2005508916A (https=) |
| AT (1) | ATE396739T1 (https=) |
| AU (1) | AU2002327049B2 (https=) |
| CA (4) | CA2776391C (https=) |
| DE (1) | DE60226911D1 (https=) |
| ES (1) | ES2307093T3 (https=) |
| WO (1) | WO2003028632A2 (https=) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005012538A2 (en) | 2003-08-01 | 2005-02-10 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Accelerated vaccination |
| ES2388527T3 (es) | 2003-09-15 | 2012-10-16 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Vacunas de VIH basadas en Env de múltiples clados de VIH |
| NZ548495A (en) | 2004-02-23 | 2009-05-31 | Crucell Holland Bv | Virus purification methods |
| US7504243B2 (en) | 2004-03-19 | 2009-03-17 | The United States Of America As Represented By The Department Of Health And Human Services | Methods for the production of biliverdin |
| AU2005243730B2 (en) * | 2004-04-12 | 2010-05-27 | Genvec, Inc. | Method of using adenoviral vectors to induce an immune response |
| JP4772045B2 (ja) * | 2004-07-16 | 2011-09-14 | アメリカ合衆国 | Ｃｍｖ／ｒ核酸コンストラクトを含むａｉｄｓに対するワクチン |
| AU2005289439B2 (en) | 2004-09-27 | 2011-12-01 | Crucell Holland B.V. | Optimized vaccines to provide protection against Ebola and other viruses |
| DK1869171T4 (en) | 2005-04-11 | 2016-01-18 | Crucell Holland Bv | Virus cleaning using ultrafiltration |
| AU2006236905B2 (en) | 2005-04-15 | 2010-06-03 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods and compositions for producing an enhanced immune response to a human papillomavirus immunogen |
| US20070185025A1 (en) * | 2005-09-11 | 2007-08-09 | The Trustees Of Columbia University In The City Of New York | Filoviral immunosuppressive peptides and uses thereof |
| US7947286B2 (en) * | 2005-10-07 | 2011-05-24 | Panthera Biopharma Llc | Drosophila cell lines producing recombinant secretable filovirus surface glycoproteins lacking the membrane spanning domain |
| SG169996A1 (en) * | 2006-02-16 | 2011-04-29 | Us Gov Health & Human Serv | Antiviral agents and vaccines against influenza |
| EP2152889B1 (en) | 2007-05-29 | 2017-03-15 | Nature Technology Corporation | Vectors and methods for genetic immunization |
| WO2009092038A1 (en) * | 2008-01-16 | 2009-07-23 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Influenza dna vaccination and methods of use thereof |
| BRPI0914847A2 (pt) | 2008-06-20 | 2020-12-15 | Basf Se | Formulação agroquímica, processo para a preparação da composição, kit de partes, usos de uma mistura de um filtro fotoprotetor orgânico, e da formulação agroquímica, e, métodos para combater insetos prejudiciais e/ou de fungos fitopatogênicos, e para controlar vegetação indesejada |
| CA2741523C (en) | 2008-10-24 | 2022-06-21 | Jonathan S. Towner | Human ebola virus species and compositions and methods thereof |
| CA2744817C (en) | 2008-11-26 | 2020-07-07 | Satiogen Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of obesity and diabetes |
| WO2010062396A2 (en) | 2008-11-26 | 2010-06-03 | Government Of The United States Of America , As Represented By The Secretary, Department Of Health And Human Services | Virus like particle compositions and methods of use |
| WO2010096561A1 (en) | 2009-02-18 | 2010-08-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Synthetic hiv/siv gag proteins and uses thereof |
| US20120219584A1 (en) | 2009-10-05 | 2012-08-30 | The United States Of America As Represented By The Secretary, Department Of Health | Protection against pandemic and seasonal strains of influenza |
| US9125411B2 (en) | 2010-04-15 | 2015-09-08 | Basf Se | UV absorbers for reducing the E/Z isomerization of pesticides |
| EP2560680B1 (en) | 2010-04-16 | 2018-11-28 | The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services | Chimpanzee adenoviral vector-based filovirus vaccines |
| EP2575821B1 (en) | 2010-05-26 | 2015-08-12 | Satiogen Pharmaceuticals, Inc. | Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions |
| DK2655604T3 (en) * | 2010-12-14 | 2018-08-06 | Us Gov Health & Human Services | ADENOVIRUS SEROTYPE-26- AND SEROTYPE-35-FILOVIRUS VACCINES |
| WO2012170814A1 (en) * | 2011-06-08 | 2012-12-13 | The Ohio State University | Norovirus immunogens and related materials and methods |
| EP3662935A1 (en) * | 2011-07-11 | 2020-06-10 | Inovio Pharmaceuticals, Inc. | Cross-protective arenavirus vaccines and their method of use |
| CA2849822C (en) | 2011-09-23 | 2021-05-11 | Gary J. Nabel, M.D. | Novel influenza hemagglutinin protein-based vaccines |
| CA2852957C (en) | 2011-10-28 | 2020-08-04 | Lumena Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of hypercholemia and cholestatic liver disease |
| CN104023727B (zh) | 2011-10-28 | 2017-04-05 | 鲁美纳医药公司 | 用于治疗小儿胆汁淤积性肝病的胆汁酸再循环抑制剂 |
| CA3194125A1 (en) * | 2012-04-12 | 2013-10-17 | The Trustees Of The University Of Pennsylvania | Filovirus consensus antigens, nucleic acid constructs and vaccines made therefrom, and methods of using same |
| US10744199B2 (en) | 2013-10-11 | 2020-08-18 | The Usa, As Represented By The Secretary, Dept. Of Health And Human Services | Epstein-Barr virus vaccines |
| TWI516602B (zh) | 2013-10-29 | 2016-01-11 | 臺北醫學大學 | 高通量篩選高表現細胞之方法及由其篩選之細胞 |
| CA2950085A1 (en) | 2014-05-27 | 2015-12-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Stabilized influenza hemagglutinin stem region trimers and uses thereof |
| EP3188752A2 (en) * | 2014-09-03 | 2017-07-12 | Bavarian Nordic A/S | Recombinant modified vaccinia virus ankara (mva) filovirus vaccine |
| SG11201705264WA (en) | 2014-12-31 | 2017-07-28 | The Usa As Represented By The Secretary Detp Of Health And Human Services | Novel multivalent nanoparticle-based vaccines |
| SG11201705782QA (en) * | 2015-01-28 | 2017-08-30 | Integrated Biotherapeutics Inc | Equine immunoglobulin compositions and uses for treating filovirus-mediated diseases |
| KR20180088458A (ko) | 2015-12-04 | 2018-08-03 | 다나-파버 캔서 인스티튜트 인크. | 암의 치료를 위한 mica/b 알파 3 도메인의 백신접종 |
| US11459619B2 (en) | 2016-02-08 | 2022-10-04 | The Johns Hopkins University | Handheld nucleic acid-based assay for rapid identification |
| SG11201901790YA (en) | 2016-09-02 | 2019-03-28 | The Usa As Represented By The Secretary | Stabilized group 2 influenza hemagglutinin stem region trimers and uses thereof |
| CN111163801A (zh) | 2017-08-02 | 2020-05-15 | 美国卫生与公众服务部 | 用于流感病毒的基于乙型肝炎纳米颗粒的疫苗 |
| US20210220463A1 (en) * | 2018-05-18 | 2021-07-22 | UNIVERSITé LAVAL | Vectors for dna vaccination |
| EP3921332A2 (en) | 2019-02-08 | 2021-12-15 | The USA, as represented by The Secretary, Department of Health and Human Services | Nanoparticle-based influenza virus vaccines and uses thereof |
| WO2024138204A1 (en) | 2022-12-22 | 2024-06-27 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Stabilized pfs48/45 proteins and uses thereof |
| WO2025184403A2 (en) * | 2024-02-29 | 2025-09-04 | Memorial Sloan-Kettering Cancer Center | Cell penetrating peptides and methods including the same |
| CN121494944A (zh) * | 2026-01-13 | 2026-02-10 | 中国人民解放军军事科学院军事医学研究院 | 一种马尔堡gp蛋白突变体、dna分子、重组载体及其应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6171596B1 (en) | 1993-12-10 | 2001-01-09 | The United States Of America As Represented By The Department Of Health And Human Services | Oligomeric HIV-1 envelope glycoproteins |
| US6027881A (en) | 1996-05-08 | 2000-02-22 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Mutant Aequorea victoria fluorescent proteins having increased cellular fluorescence |
| US6200959B1 (en) | 1996-12-04 | 2001-03-13 | Powerject Vaccines Inc. | Genetic induction of anti-viral immune response and genetic vaccine for filovirus |
| WO1999032147A1 (en) * | 1997-12-23 | 1999-07-01 | The Regents Of The University Of Michigan | Immunization for ebola virus infection |
| US6630144B1 (en) | 1999-08-30 | 2003-10-07 | The United States Of America As Represented By The Secretary Of The Army | Monoclonal antibodies to Ebola glycoprotein |
-
2002
- 2002-09-24 WO PCT/US2002/030251 patent/WO2003028632A2/en not_active Ceased
- 2002-09-24 US US10/491,121 patent/US7635688B2/en not_active Expired - Lifetime
- 2002-09-24 CA CA 2776391 patent/CA2776391C/en not_active Expired - Lifetime
- 2002-09-24 AU AU2002327049A patent/AU2002327049B2/en not_active Expired
- 2002-09-24 CA CA2462455A patent/CA2462455C/en not_active Expired - Lifetime
- 2002-09-24 EP EP02761814A patent/EP1504112A4/en not_active Ceased
- 2002-09-24 CA CA2776522A patent/CA2776522C/en not_active Expired - Lifetime
- 2002-09-24 ES ES05013732T patent/ES2307093T3/es not_active Expired - Lifetime
- 2002-09-24 AT AT05013732T patent/ATE396739T1/de not_active IP Right Cessation
- 2002-09-24 JP JP2003531968A patent/JP2005508916A/ja active Pending
- 2002-09-24 CA CA2776272A patent/CA2776272C/en not_active Expired - Lifetime
- 2002-09-24 DE DE60226911T patent/DE60226911D1/de not_active Expired - Lifetime
-
2004
- 2004-11-24 US US10/997,120 patent/US7094598B2/en not_active Expired - Lifetime
-
2005
- 2005-09-27 JP JP2005280131A patent/JP4198148B2/ja not_active Expired - Lifetime
-
2009
- 2009-11-04 US US12/612,579 patent/US8106026B2/en not_active Expired - Fee Related
- 2009-11-04 US US12/612,625 patent/US8124592B2/en not_active Expired - Fee Related
- 2009-11-04 US US12/612,621 patent/US8106027B2/en not_active Expired - Fee Related
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